Cyclin-Dependent Kinase Inhibitor p21
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Subject Areas on Research
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A novel, non-apoptotic role for Scythe/BAT3: a functional switch between the pro- and anti-proliferative roles of p21 during the cell cycle.
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A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism.
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Aberrant expression of p53, p21, cyclin D1, and Bcl2 and their clinicopathological correlation in ampullary adenocarcinoma.
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Aberrant expression of tumor suppressor proteins in the Ewing family of tumors.
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Absence of radiation-induced G1 arrest in two closely related human lymphoblast cell lines that differ in p53 status.
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Activation of extracellular signal-regulated kinase (ERK) in G2 phase delays mitotic entry through p21CIP1.
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Association between p21 Ser31Arg polymorphism and cancer risk: a meta-analysis.
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Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene.
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CD30 activates both the canonical and alternative NF-kappaB pathways in anaplastic large cell lymphoma cells.
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CD30-activation-mediated growth inhibition of anaplastic large-cell lymphoma cell lines: apoptosis or cell-cycle arrest?
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CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development.
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Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis.
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Cell cycle deregulation and xeroderma pigmentosum group C cell transformation.
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Cell cycle regulation of human pancreatic cancer by tamoxifen.
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Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation.
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Cyclin-binding motifs are essential for the function of p21CIP1.
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Cytoprotective effects of hematopoietic growth factors on primary human acute myeloid leukemias are not mediated through changes in BCL-2, bax, or p21WAF1/CIP1.
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DNA damage induces phosphorylation of the amino terminus of p53.
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Dimethylfumarate effectively inhibits lymphangiogenesis via p21 induction and G1 cell cycle arrest.
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Diminished capacity for p53 in mediating a radiation-induced G1 arrest in established human tumor cell lines.
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Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation.
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Divergent gene regulation and growth effects by NF-kappa B in epithelial and mesenchymal cells of human skin.
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Down-regulation of neu/HER-2 by interferon-gamma in prostate cancer cells.
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Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state.
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Functional analysis of the transforming growth factor beta responsive elements in the WAF1/Cip1/p21 promoter.
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Genetic polymorphisms of p21 and risk of second primary malignancy in patients with index squamous cell carcinoma of the head and neck.
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Genetic polymorphisms of p21 are associated with risk of squamous cell carcinoma of the head and neck.
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Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control study.
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Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.
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Growth factor modulation of p53-mediated growth arrest versus apoptosis.
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HIV-1 Vpr activates cell cycle inhibitor p21/Waf1/Cip1: a potential mechanism of G2/M cell cycle arrest.
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Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma.
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Human T-cell leukemia virus type 1 Tax activates cyclin-dependent kinase inhibitor p21/Waf1/Cip1 expression through a p53-independent mechanism: Inhibition of cdk2.
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Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells.
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In vitro and in vivo antitumor effect of the anti-CD26 monoclonal antibody 1F7 on human CD30+ anaplastic large cell T-cell lymphoma Karpas 299.
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Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
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Induction of p21waf1 expression and growth inhibition by transforming growth factor beta involve the tumor suppressor gene DPC4 in human pancreatic adenocarcinoma cells.
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Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: effect of p53 upregulation.
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Inhibition of human immunodeficiency virus type 1 transcription by chemical cyclin-dependent kinase inhibitors.
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Inhibition of the 3-hydroxy-3-methylglutaryl-coenzyme A reductase pathway induces p53-independent transcriptional regulation of p21(WAF1/CIP1) in human prostate carcinoma cells.
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Interaction of the p53-regulated protein Gadd45 with proliferating cell nuclear antigen.
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Interferon Regulatory Factor 1 (IRF-1) induces p21(WAF1/CIP1) dependent cell cycle arrest and p21(WAF1/CIP1) independent modulation of survivin in cancer cells.
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Knockdown of the cell cycle inhibitor p21 enhances cartilage formation by induced pluripotent stem cells.
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Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues.
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Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1.
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Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells.
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MDM2 antagonists overcome intrinsic resistance to CDK4/6 inhibition by inducing p21.
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Male mice deficient in microsomal epoxide hydrolase are not susceptible to benzene-induced toxicity.
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Mice lacking the p53-effector gene Gadd45a develop a lupus-like syndrome.
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MutLalpha and proliferating cell nuclear antigen share binding sites on MutSbeta.
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Mutational analysis of the p21/WAF1/CIP1/SDI1 coding region in human tumor cell lines.
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Nuclear pore component Nup98 is a potential tumor suppressor and regulates posttranscriptional expression of select p53 target genes.
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Overexpression of p21(waf1) in human T-cell lymphotropic virus type 1-infected cells and its association with cyclin A/cdk2.
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Polymorphisms of TP53 Arg72Pro, but not p73 G4C14>A4TA4 and p21 Ser31Arg, contribute to risk of cutaneous melanoma.
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Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer.
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Potential role of WAF1/Cip1/p21 as a mediator of TGF-beta cytoinhibitory effect.
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Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer.
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RB regulates transcription of the p21/WAF1/CIP1 gene.
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Radio-induced modulation of transforming growth factor beta1 sensitivity in a p53 wild-type human colorectal-cancer cell line.
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Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells.
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Ras induces p21Cip1/Waf1 cyclin kinase inhibitor transcriptionally through Sp1-binding sites.
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Relationship between p21 expression and mutation of the p53 tumor suppressor gene in normal and malignant ovarian epithelial cells.
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Replicative senescence revisited.
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Ribozyme-mediated induction of apoptosis in human cancer cells by targeted repair of mutant p53 RNA.
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Small contribution of G1 checkpoint control manipulation to modulation of p53-mediated apoptosis.
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Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent.
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Spitz nevi and atypical Spitz nevi/tumors: a histologic and immunohistochemical analysis.
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Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.
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Suppression of tumorigenesis and induction of p15(ink4b) by Smad4/DPC4 in human pancreatic cancer cells.
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Targeted cytotoxic somatostatin analogue AN-238 inhibits somatostatin receptor-positive experimental colon cancers independently of their p53 status.
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The G protein-coupled receptor GPR30 inhibits proliferation of estrogen receptor-positive breast cancer cells.
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The MEK pathway is required for stimulation of p21(WAF1/CIP1) by transforming growth factor-beta.
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The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways.
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The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells.
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The viral oncoprotein E1A blocks transforming growth factor beta-mediated induction of p21/WAF1/Cip1 and p15/INK4B.
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Transcription of the RelB gene is regulated by NF-kappaB.
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Transcriptional activation of p21(waf1/cip1) by alkylphospholipids: role of the mitogen-activated protein kinase pathway in the transactivation of the human p21(waf1/cip1) promoter by Sp1.
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Transforming growth factor beta 1 can induce CIP1/WAF1 expression independent of the p53 pathway in ovarian cancer cells.
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Transforming growth factor beta induces the cyclin-dependent kinase inhibitor p21 through a p53-independent mechanism.
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Transforming growth factor-beta differentially inhibits epithelial ovarian carcinoma cells from primary and metastatic isolates without up-regulation of p21WAF1.
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Transforming growth factor-beta-mediated p15(INK4B) induction and growth inhibition in astrocytes is SMAD3-dependent and a pathway prominently altered in human glioma cell lines.
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Tumor suppressor gene Smad4/DPC4, its downstream target genes, and regulation of cell cycle.
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Type I interferon induction of the Cdk-inhibitor p21WAF1 is accompanied by ordered G1 arrest, differentiation and apoptosis of the Daudi B-cell line.
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Type III TGF-β receptor enhances colon cancer cell migration and anchorage-independent growth.
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UV radiation is a transcriptional inducer of p21(Cip1/Waf1) cyclin-kinase inhibitor in a p53-independent manner.
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Ubiquitylation of p53 by the APC/C inhibitor Trim39.
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Up-regulated P21CIP1 expression is part of the regulation quantitatively controlling serum deprivation-induced apoptosis.
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Up-regulation of tumor susceptibility gene 101 conveys poor prognosis through suppression of p21 expression in ovarian cancer.
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Variant genotypes of CDKN1A and CDKN1B are associated with an increased risk of breast cancer in Chinese women.
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Variations in Prkdc and susceptibility to benzene-induced toxicity in mice.
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WAF1/CIP1 is induced in p53-mediated G1 arrest and apoptosis.
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Wogonin and fisetin induction of apoptosis through activation of caspase 3 cascade and alternative expression of p21 protein in hepatocellular carcinoma cells SK-HEP-1.
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p21 protects "Super p53" mice from the radiation-induced gastrointestinal syndrome.
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p53 functional impairment and high p21waf1/cip1 expression in human T-cell lymphotropic/leukemia virus type I-transformed T cells.
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p53-dependent G1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein.
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p53-dependent induction of heat shock protein 27 (HSP27) expression.
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