Cyclin-Dependent Kinase Inhibitor p27
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Subject Areas on Research
- A novel role for the cyclin-dependent kinase inhibitor p27(Kip1) in angiotensin II-stimulated vascular smooth muscle cell hypertrophy.
- Activation of the PKB/Akt pathway in histological benign prostatic tissue adjacent to the primary malignant lesions.
- Association between the V109G polymorphism of the p27 gene and the risk and progression of oral squamous cell carcinoma.
- Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1.
- CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development.
- CTLA-4-Mediated inhibition of early events of T cell proliferation.
- Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis.
- Cell cycle deregulation and xeroderma pigmentosum group C cell transformation.
- Differential and complementary effects of glucose and prolactin on islet DNA synthesis and gene expression.
- Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary.
- Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation.
- E2F-1 accumulation bypasses a G1 arrest resulting from the inhibition of G1 cyclin-dependent kinase activity.
- Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis.
- Expression of p27 in residual rectal cancer after preoperative chemoradiation predicts long-term outcome.
- Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53.
- Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1.
- Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control study.
- Genetic variants of p27 and p21 as predictors for risk of second primary malignancy in patients with index squamous cell carcinoma of head and neck.
- Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma.
- Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells.
- Immunologic targeting of FOXP3 in inflammatory breast cancer cells.
- Inhibition of NF-kappaB1 and NF-kappaB2 activation in prostate cancer cells treated with antibody against the carboxyl terminal domain of GRP78: effect of p53 upregulation.
- Lack of cyclin-dependent kinase 4 inhibits c-myc tumorigenic activities in epithelial tissues.
- Loss of G(1)/S checkpoint in human immunodeficiency virus type 1-infected cells is associated with a lack of cyclin-dependent kinase inhibitor p21/Waf1.
- Loss of nuclear pro-IL-16 facilitates cell cycle progression in human cutaneous T cell lymphoma.
- Low-dose genistein induces cyclin-dependent kinase inhibitors and G(1) cell-cycle arrest in human prostate cancer cells.
- Molecular profiling of human mammary gland links breast cancer risk to a p27(+) cell population with progenitor characteristics.
- Myc and Ras collaborate in inducing accumulation of active cyclin E/Cdk2 and E2F.
- Neutrophil elastase inhibition of cell cycle progression in airway epithelial cells in vitro is mediated by p27kip1.
- Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation.
- Predicting biochemical recurrence after radical prostatectomy for patients with organ-confined disease using p27 expression.
- Proteasome-mediated degradation and functions of hematopoietic progenitor kinase 1 in pancreatic cancer.
- Reciprocal control of Forkhead box O 3a and c-Myc via the phosphatidylinositol 3-kinase pathway coordinately regulates p27Kip1 levels.
- Recognizing features that are dissimilar in male and female breast cancer: expression of p21Waf1 and p27Kip1 using an immunohistochemical assay.
- Regulation of nuclear Prointerleukin-16 and p27(Kip1) in primary human T lymphocytes.
- Skp2 deficiency inhibits chemical skin tumorigenesis independent of p27(Kip1) accumulation.
- TGF-beta through Smad3 signaling stimulates vascular smooth muscle cell proliferation and neointimal formation.
- The type III transforming growth factor-β receptor inhibits proliferation, migration, and adhesion in human myeloma cells.
- Variant genotypes of CDKN1A and CDKN1B are associated with an increased risk of breast cancer in Chinese women.
- c-Myc represses FOXO3a-mediated transcription of the gene encoding the p27(Kip1) cyclin dependent kinase inhibitor.
- p27 and cyclin D1 abnormalities in uterine papillary serous carcinoma.
- p27Kip1 in stage III colon cancer: implications for outcome following adjuvant chemotherapy in cancer and leukemia group B protocol 89803.
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Keywords of People
- Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology