NFATC Transcription Factors

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  Subject Areas on Research

  • A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. 
  • A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. 
  • A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression. 
  • Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy. 
  • Assay for protein modification by poly-ADP-ribose in vitro. 
  • B-cell receptor-mediated NFATc1 activation induces IL-10/STAT3/PD-L1 signaling in diffuse large B-cell lymphoma. 
  • CTLA-4-Mediated inhibition of early events of T cell proliferation. 
  • Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo. 
  • Calcineurin finds a new partner in the L-type Ca2+ channel. 
  • Calcineurin mutants render T lymphocytes resistant to cyclosporin A. 
  • Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction. 
  • Calcineurin. Structure, function, and inhibition. 
  • Calcineurin: a central controller of signalling in eukaryotes. 
  • Calcium-dependent gene regulation in myocyte hypertrophy and remodeling. 
  • Chemokine production by G protein-coupled receptor activation in a human mast cell line: roles of extracellular signal-regulated kinase and NFAT. 
  • Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. 
  • Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV. 
  • Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint. 
  • Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene. 
  • Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy. 
  • Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling. 
  • Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease. 
  • Genetic variation determines VEGF-A plasma levels in cancer patients. 
  • Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway. 
  • Gq signaling causes glomerular injury by activating TRPC6. 
  • Gq-dependent signaling upregulates COX2 in glomerular podocytes. 
  • Homer modulates NFAT-dependent signaling during muscle differentiation. 
  • Hypoxia reprograms calcium signaling and regulates myoglobin expression. 
  • Identification of calcium-modulating cyclophilin ligand (CAML) as transducer of angiotensin II-mediated nuclear factor of activated T cells (NFAT) activation. 
  • Induction of SENP1 in myocardium contributes to abnormities of mitochondria and cardiomyopathy. 
  • Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation. 
  • Inhibition of the NFAT pathway alleviates amyloid β neurotoxicity in a mouse model of Alzheimer's disease. 
  • LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. 
  • MEF2 responds to multiple calcium-regulated signals in the control of skeletal muscle fiber type. 
  • Macrophage NFATC2 mediates angiogenic signaling during mycobacterial infection. 
  • Myocardium and BMP signaling are required for endocardial differentiation. 
  • NF-kappaB cis-acting motifs of the human immunodeficiency virus (HIV) long terminal repeat regulate HIV transcription in human macrophages. 
  • NIP45 controls the magnitude of the type 2 T helper cell response. 
  • Nerve activity-dependent modulation of calcineurin signaling in adult fast and slow skeletal muscle fibers. 
  • Neurotrophins and netrins require calcineurin/NFAT signaling to stimulate outgrowth of embryonic axons. 
  • Novel pathogenic variants in FOXP3 in fetuses with echogenic bowel and skin desquamation identified by ultrasound. 
  • Phosphodiesterase 5 inhibition ameliorates angiontensin II-induced podocyte dysmotility via the protein kinase G-mediated downregulation of TRPC6 activity. 
  • Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses. 
  • Pimecrolimus enhances TLR2/6-induced expression of antimicrobial peptides in keratinocytes. 
  • Positive selection on a human-specific transcription factor binding site regulating IL4 expression. 
  • Regulation of transcription factor NFAT by ADP-ribosylation. 
  • Remodeling muscles with calcineurin. 
  • Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. 
  • Role of transcription factor NFAT in glucose and insulin homeostasis. 
  • Secreted frizzle-related protein 2 stimulates angiogenesis via a calcineurin/NFAT signaling pathway. 
  • Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation. 
  • Solution structure of the core NFATC1/DNA complex. 
  • Stimulation of calcineurin signaling attenuates the dystrophic pathology in mdx mice. 
  • TRPC3 channels confer cellular memory of recent neuromuscular activity. 
  • Targeting the hexosamine biosynthetic pathway and O-linked N-acetylglucosamine cycling for therapeutic and imaging capabilities in diffuse large B-cell lymphoma. 
  • Unusual Rel-like architecture in the DNA-binding domain of the transcription factor NFATc. 
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  Keywords of People

  • Wray, Gregory Allan, Professor of Biology, Evolutionary Anthropology