STAT1 Transcription Factor
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Subject Areas on Research
- A novel mechanism of skin tumor promotion involving interferon-gamma (IFNγ)/signal transducer and activator of transcription-1 (Stat1) signaling.
- A soluble factor(s) secreted from CD8(+) T lymphocytes inhibits human immunodeficiency virus type 1 replication through STAT1 activation.
- ADAP2 Is an Interferon Stimulated Gene That Restricts RNA Virus Entry.
- Caspase-8 levels correlate with the expression of signal transducer and activator of transcription 1 in high-grade but not lower grade neuroblastoma.
- Chlamydia trachomatis-infected cells and uninfected-bystander cells exhibit diametrically opposed responses to interferon gamma.
- Dominant gain-of-function STAT1 mutations in FOXP3 wild-type immune dysregulation-polyendocrinopathy-enteropathy-X-linked-like syndrome.
- Down-regulation of neu/HER-2 by interferon-gamma in prostate cancer cells.
- Effect of obesity on pulmonary inflammation induced by acute ozone exposure: role of interleukin-6.
- Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain.
- Functional genomics identifies type I interferon pathway as central for host defense against Candida albicans.
- Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia.
- Gonococcal lipooligosaccharide suppresses HIV infection in human primary macrophages through induction of innate immunity.
- HIV-1 Infection Primes Macrophages Through STAT Signaling to Promote Enhanced Inflammation and Viral Replication.
- Hepcidin expression in human airway epithelial cells is regulated by interferon-γ.
- Human DNA methylation signatures differentiate persistent from resolving MRSA bacteremia.
- Human immunodeficiency virus type 1 (HIV-1) induces activation of multiple STATs in CD4+ cells of lymphocyte or monocyte/macrophage lineages.
- IFN-beta inhibits human Th17 cell differentiation.
- IL-27 signaling activates skin cells to induce innate antiviral proteins and protects against Zika virus infection.
- Inhibition of transforming growth factor-beta/SMAD signalling by the interferon-gamma/STAT pathway.
- Irgm1 protects hematopoietic stem cells by negative regulation of IFN signaling.
- Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations.
- Janus kinase inhibitors for atopic dermatitis: a promising treatment modality.
- K12/SECTM1, an interferon-γ regulated molecule, synergizes with CD28 to costimulate human T cell proliferation.
- Long Noncoding RNA Ceruloplasmin Promotes Cancer Growth by Altering Glycolysis.
- Murine noroviruses comprising a single genogroup exhibit biological diversity despite limited sequence divergence.
- Non-erythroid effects of erythropoietin.
- Opposing actions of Stat1 and Stat6 on IL-13-induced up-regulation of early growth response-1 and platelet-derived growth factor ligands in pulmonary fibroblasts.
- Osteopontin and protein kinase C regulate PDLIM2 activation and STAT1 ubiquitination in LPS-treated murine macrophages.
- Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages.
- Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis.
- Osteopontin regulates ubiquitin-dependent degradation of Stat1 in murine mammary epithelial tumor cells.
- Peroxisome proliferator-activated receptor gamma negatively regulates IFN-beta production in Toll-like receptor (TLR) 3- and TLR4-stimulated macrophages by preventing interferon regulatory factor 3 binding to the IFN-beta promoter.
- SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.
- STAT1 drives tumor progression in serous papillary endometrial cancer.
- STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection.
- STAT1-induced ASPP2 transcription identifies a link between neuroinflammation, cell polarity, and tumor suppression.
- Sphingosine-1-phosphate inhibits IL-1-induced expression of C-C motif ligand 5 via c-Fos-dependent suppression of IFN-β amplification loop.
- Stat1 acetylation inhibits inducible nitric oxide synthase expression in interferon-gamma-treated RAW264.7 murine macrophages.
- Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis.
- Systems Immunology Analyses of STAT1 Gain-of-Function Immune Phenotypes Reveal Heterogeneous Response to IL-6 and Broad Immunometabolic Roles for STAT1.
- The IFN-inducible GTPase LRG47 (Irgm1) negatively regulates TLR4-triggered proinflammatory cytokine production and prevents endotoxemia.
- The function of gamma interferon-inducible GTP-binding protein IGTP in host resistance to Toxoplasma gondii is Stat1 dependent and requires expression in both hematopoietic and nonhematopoietic cellular compartments.
- Toll-like receptor (TLR)7 and TLR9 agonists enhance interferon (IFN) beta-1a's immunoregulatory effects on B cells in patients with relapsing-remitting multiple sclerosis (RRMS).
- Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells.
- Tumor cells upregulate normoxic HIF-1α in response to doxorubicin.
- Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants.
- Unique aspects of IFN-γ/STAT1 signaling in neurons.
- Vanadium-induced STAT-1 activation in lung myofibroblasts requires H2O2 and P38 MAP kinase.
- miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma.
- miR-21 depletion in macrophages promotes tumoricidal polarization and enhances PD-1 immunotherapy.