STAT3 Transcription Factor

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  Subject Areas on Research

  • 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6-JAK-STAT3 Signaling in Prostate Cancer Cells. 
  • A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. 
  • A novel EGFR isoform confers increased invasiveness to cancer cells. 
  • A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells. 
  • ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis. 
  • APOL1 kidney disease risk variants cause cytotoxicity by depleting cellular potassium and inducing stress-activated protein kinases. 
  • Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis. 
  • Abi1 loss drives prostate tumorigenesis through activation of EMT and non-canonical WNT signaling. 
  • Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. 
  • Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation. 
  • An Endothelial Hsp70-TLR4 Axis Limits Nox3 Expression and Protects Against Oxidant Injury in Lungs. 
  • An oxidative stress-based mechanism of doxorubicin cytotoxicity suggests new therapeutic strategies in ABC-DLBCL. 
  • Associations of potentially functional variants in IL-6, JAKs and STAT3 with gastric cancer risk in an eastern Chinese population. 
  • B-cell receptor-mediated NFATc1 activation induces IL-10/STAT3/PD-L1 signaling in diffuse large B-cell lymphoma. 
  • BMP10 suppresses hepatocellular carcinoma progression via PTPRS-STAT3 axis. 
  • Biological activity of interleukin-10 in the central nervous system. 
  • Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury. 
  • Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy. 
  • Cigarette smoke-induced MMP2 and MMP9 secretion from aortic vascular smooth cells is mediated via the Jak/Stat pathway. 
  • Clinical implications of phosphorylated STAT3 expression in De Novo diffuse large B-cell lymphoma. 
  • Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations. 
  • Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. 
  • Cryptococcus neoformans phospholipase B1 activates host cell Rac1 for traversal across the blood-brain barrier. 
  • Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. 
  • Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. 
  • Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells. 
  • Cytoplasmic polyadenylation element binding protein deficiency stimulates PTEN and Stat3 mRNA translation and induces hepatic insulin resistance. 
  • Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. 
  • Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice. 
  • Effect of obesity on pulmonary inflammation induced by acute ozone exposure: role of interleukin-6. 
  • Endothelial STAT3 is essential for the protective effects of HO-1 in oxidant-induced lung injury. 
  • Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. 
  • Epidermal growth factor receptor variant III mediates head and neck cancer cell invasion via STAT3 activation. 
  • Erythropoietin Stimulates Tumor Growth via EphB4. 
  • FTO Suppresses STAT3 Activation and Modulates Proinflammatory Interferon-Stimulated Gene Expression. 
  • Genetic Variants in CPA6 and PRPF31 Are Associated With Variation in Response to Metformin in Individuals With Type 2 Diabetes. 
  • Genome-wide analysis of STAT target genes: elucidating the mechanism of STAT-mediated oncogenesis. 
  • HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis. 
  • HIV-1 Infection Primes Macrophages Through STAT Signaling to Promote Enhanced Inflammation and Viral Replication. 
  • HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. 
  • Haplotype of signal transducer and activator of transcription 3 gene predicts cardiovascular disease in dialysis patients. 
  • Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO. 
  • Human immunodeficiency virus type 1 (HIV-1) induces activation of multiple STATs in CD4+ cells of lymphocyte or monocyte/macrophage lineages. 
  • IFN-beta inhibits human Th17 cell differentiation. 
  • IL-1R signaling promotes STAT3 and NF-κB factor recruitment to distal cis-regulatory elements that regulate Il17a/f transcription. 
  • IL-6/STAT3 promotes regeneration of airway ciliated cells from basal stem cells. 
  • Identification of a genetic signature of activated signal transducer and activator of transcription 3 in human tumors. 
  • In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats. 
  • Interleukin-1beta mediates human airway epithelial cell migration via NF-kappaB. 
  • Interleukin-6 induces hepcidin expression through STAT3. 
  • Inverse Correlation of STAT3 and MEK Signaling Mediates Resistance to RAS Pathway Inhibition in Pancreatic Cancer. 
  • JAK-STAT3 pathway regulates spinal astrocyte proliferation and neuropathic pain maintenance in rats. 
  • JAK2 inhibition prevents innate immune responses and rescues animals from sepsis. 
  • Jakinibs for the treatment of immune dysregulation in patients with gain-of-function signal transducer and activator of transcription 1 (STAT1) or STAT3 mutations. 
  • LIF negatively regulates tumour-suppressor p53 through Stat3/ID1/MDM2 in colorectal cancers. 
  • Leptin and its receptor are overexpressed in brain tumors and correlate with the degree of malignancy. 
  • Lethal-7 is down-regulated by the hepatitis B virus x protein and targets signal transducer and activator of transcription 3. 
  • Leukemia Inhibitory Factor Promotes Castration-resistant Prostate Cancer and Neuroendocrine Differentiation by Activated ZBTB46. 
  • M-HIFU inhibits tumor growth, suppresses STAT3 activity and enhances tumor specific immunity in a transplant tumor model of prostate cancer. 
  • Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing. 
  • MeCP2 reinforces STAT3 signaling and the generation of effector CD4+ T cells by promoting miR-124-mediated suppression of SOCS5. 
  • Mechanism of shortened bones in mucopolysaccharidosis VII. 
  • Meteorin-like facilitates skeletal muscle repair through a Stat3/IGF-1 mechanism. 
  • Muscle mTORC1 suppression by IL-6 during cancer cachexia: a role for AMPK. 
  • Muscle oxidative capacity during IL-6-dependent cancer cachexia. 
  • Nef stimulates proliferation of glomerular podocytes through activation of Src-dependent Stat3 and MAPK1,2 pathways. 
  • Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3. 
  • Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants. 
  • Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. 
  • PD-L1 is commonly expressed and transcriptionally regulated by STAT3 and MYC in ALK-negative anaplastic large-cell lymphoma. 
  • Partial inhibition of gp130-Jak-Stat3 signaling prevents Wnt-β-catenin-mediated intestinal tumor growth and regeneration. 
  • Promotion of the development of enteric neurons and glia by neuropoietic cytokines: interactions with neurotrophin-3. 
  • Protein Inhibitor of Activated STAT3 (PIAS3) Is Down-Regulated in Eutopic Endometrium of Women with Endometriosis. 
  • Reduction of Stat3 activity attenuates HIV-induced kidney injury. 
  • Resistance to Durvalumab and Durvalumab plus Tremelimumab Is Associated with Functional STK11 Mutations in Patients with Non-Small Cell Lung Cancer and Is Reversed by STAT3 Knockdown. 
  • SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway. 
  • STAT-3 overexpression and p21 up-regulation accompany impaired regeneration of fatty livers. 
  • STAT3 Regulates Self-Renewal of Adult Muscle Satellite Cells during Injury-Induced Muscle Regeneration. 
  • STAT3-driven upregulation of TLR2 promotes gastric tumorigenesis independent of tumor inflammation. 
  • STAT3-enhancing germline mutations contribute to tumor-extrinsic immune evasion. 
  • STAT3-mediated attenuation of CCl4-induced mouse liver fibrosis by the protein kinase inhibitor sorafenib. 
  • STAT3-mediated coincidence detection regulates noncanonical immediate early gene induction. 
  • Salmonella Activation of STAT3 Signaling by SarA Effector Promotes Intracellular Replication and Production of IL-10. 
  • Self-inflicted DNA double-strand breaks sustain tumorigenicity and stemness of cancer cells. 
  • Signal Transducer and Activator of Transcription 3, Mediated Remodeling of the Tumor Microenvironment Results in Enhanced Tumor Drug Delivery in a Mouse Model of Pancreatic Cancer. 
  • Signal integration and gene induction by a functionally distinct STAT3 phosphoform. 
  • Signal transducer and activator of transcription 3 is required for the oncogenic effects of non-small-cell lung cancer-associated mutations of the epidermal growth factor receptor. 
  • Sox2 cooperates with inflammation-mediated Stat3 activation in the malignant transformation of foregut basal progenitor cells. 
  • Sparstolonin B (SsnB) attenuates liver fibrosis via a parallel conjugate pathway involving P53-P21 axis, TGF-beta signaling and focal adhesion that is TLR4 dependent. 
  • Stat3 activation regulates the expression of matrix metalloproteinase-2 and tumor invasion and metastasis. 
  • Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. 
  • Stat3 binds to mtDNA and regulates mitochondrial gene expression in keratinocytes. 
  • Stimulation of different subtypes of angiotensin II receptors, AT1 and AT2 receptors, regulates STAT activation by negative crosstalk. 
  • Successful haploidentical donor hematopoietic stem cell transplant and restoration of STAT3 function in an adolescent with autosomal dominant hyper-IgE syndrome. 
  • Surfactant protein C dampens inflammation by decreasing JAK/STAT activation during lung repair. 
  • Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis. 
  • TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. 
  • Targeting interleukin 6 signaling suppresses glioma stem cell survival and tumor growth. 
  • Targeting the cyclophilin domain of Ran-binding protein 2 (Ranbp2) with novel small molecules to control the proteostasis of STAT3, hnRNPA2B1 and M-opsin. 
  • Temperature-dependent sex determination is mediated by pSTAT3 repression of Kdm6b. 
  • The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling. 
  • The JAK2/STAT3 signaling pathway is required for growth of CD44⁺CD24⁻ stem cell-like breast cancer cells in human tumors. 
  • The Salmonella Secreted Effector SarA/SteE Mimics Cytokine Receptor Signaling to Activate STAT3. 
  • The molecular pathogenesis of STAT3-driven gastric tumourigenesis in mice is independent of IL-17. 
  • The nuclear receptor RORα protects against angiotensin II-induced cardiac hypertrophy and heart failure. 
  • The role of tregs in human glioma patients and their inhibition with a novel STAT-3 inhibitor. 
  • The synthetic triterpenoids CDDO-methyl ester and CDDO-ethyl amide prevent lung cancer induced by vinyl carbamate in A/J mice. 
  • Translational profiling of cardiomyocytes identifies an early Jak1/Stat3 injury response required for zebrafish heart regeneration. 
  • Tumor Cell-Independent Estrogen Signaling Drives Disease Progression through Mobilization of Myeloid-Derived Suppressor Cells. 
  • Tumor-induced reshuffling of lipid composition on the endoplasmic reticulum membrane sustains macrophage survival and pro-tumorigenic activity. 
  • Tyrosine phosphorylation is required for functional activation of disulfide-containing constitutively active STAT mutants. 
  • Unexpected implications of STAT3 acetylation revealed by genetic encoding of acetyl-lysine. 
  • Unphosphorylated STAT3 modulates alpha 7 nicotinic receptor signaling and cytokine production in sepsis. 
  • mTORC1 inhibition restricts inflammation-associated gastrointestinal tumorigenesis in mice. 
  • miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma. 
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  Keywords of People

  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Shinohara, Mari L., Associate Professor of Immunology, Cell Biology