STAT5 Transcription Factor
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Subject Areas on Research
- A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells.
- A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation.
- ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling.
- Akt is required for Stat5 activation and mammary differentiation.
- Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways.
- CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling.
- DNA-remethylation around a STAT5-binding enhancer in the alphaS1-casein promoter is associated with abrupt shutdown of alphaS1-casein synthesis during acute mastitis.
- Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta.
- Differential and complementary effects of glucose and prolactin on islet DNA synthesis and gene expression.
- Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain.
- Extracellular signal-regulated kinase 5 (ERK5) mediates prolactin-stimulated adult neurogenesis in the subventricular zone and olfactory bulb.
- Familial polycythemia due to truncations of the erythropoietin receptor.
- Fatty acid transport protein 2 reprograms neutrophils in cancer.
- Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling.
- Genome-wide analysis of STAT target genes: elucidating the mechanism of STAT-mediated oncogenesis.
- Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I.
- Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression.
- Human immunodeficiency virus type 1 (HIV-1) induces activation of multiple STATs in CD4+ cells of lymphocyte or monocyte/macrophage lineages.
- Hydrophobic residues Phe751 and Leu753 are essential for STAT5 transcriptional activity.
- IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival.
- Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors.
- Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification.
- JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma.
- JAK2 is required for induction of the murine DUB-1 gene.
- Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation.
- Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma.
- Loss of Nuclear Localized Parathyroid Hormone-Related Protein in Primary Breast Cancer Predicts Poor Clinical Outcome and Correlates with Suppressed Stat5 Signaling.
- Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.
- Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure.
- Low levels of Stat5a protein in breast cancer are associated with tumor progression and unfavorable clinical outcomes.
- Non-erythroid effects of erythropoietin.
- Potent and selective inhibition of polycythemia by the quinoxaline JAK2 inhibitor NVP-BSK805.
- Prolactin induction of insulin gene transcription: roles of glucose and signal transducer and activator of transcription 5.
- Prolactin suppresses a progestin-induced CK5-positive cell population in luminal breast cancer through inhibition of progestin-driven BCL6 expression.
- Prolactin-Stat5 signaling in breast cancer is potently disrupted by acidosis within the tumor microenvironment.
- Receptors that induce erythroid differentiation of Ba/F3 cells: structural requirements and effect on STAT5 binding.
- Stat5 promotes metastatic behavior of human prostate cancer cells in vitro and in vivo.
- TCR stimulation without co-stimulatory signals induces expression of "tolerogenic" genes in memory CD4 T cells but does not compromise cell proliferation.
- The histone deacetylase inhibitor valproic acid lessens NK cell action against oncolytic virus-infected glioblastoma cells by inhibition of STAT5/T-BET signaling and generation of gamma interferon.
- The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy.
- Transcription factor Stat3 stimulates metastatic behavior of human prostate cancer cells in vivo, whereas Stat5b has a preferential role in the promotion of prostate cancer cell viability and tumor growth.
- Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling.
- Truncated STAT proteins are prevalent at relapse of acute myeloid leukemia.
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Keywords of People
- Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology