STAT5 Transcription Factor
-
Subject Areas on Research
- A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation.
- ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling.
- Akt is required for Stat5 activation and mammary differentiation.
- Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways.
- DNA-remethylation around a STAT5-binding enhancer in the alphaS1-casein promoter is associated with abrupt shutdown of alphaS1-casein synthesis during acute mastitis.
- Differential and complementary effects of glucose and prolactin on islet DNA synthesis and gene expression.
- Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain.
- Familial polycythemia due to truncations of the erythropoietin receptor.
- Fatty acid transport protein 2 reprograms neutrophils in cancer.
- Genome-wide analysis of STAT target genes: elucidating the mechanism of STAT-mediated oncogenesis.
- Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I.
- Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression.
- Human immunodeficiency virus type 1 (HIV-1) induces activation of multiple STATs in CD4+ cells of lymphocyte or monocyte/macrophage lineages.
- Hydrophobic residues Phe751 and Leu753 are essential for STAT5 transcriptional activity.
- IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival.
- Interleukin-3-induced activation of the JAK/STAT pathway is prolonged by proteasome inhibitors.
- Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification.
- JAK-STAT and G-protein-coupled receptor signaling pathways are frequently altered in epitheliotropic intestinal T-cell lymphoma.
- JAK2 is required for induction of the murine DUB-1 gene.
- Janus kinase 3 (JAK3) deficiency: clinical, immunologic, and molecular analyses of 10 patients and outcomes of stem cell transplantation.
- Janus kinase 3-activating mutations identified in natural killer/T-cell lymphoma.
- Loss of Nuclear Localized Parathyroid Hormone-Related Protein in Primary Breast Cancer Predicts Poor Clinical Outcome and Correlates with Suppressed Stat5 Signaling.
- Loss of beta-catenin impairs the renewal of normal and CML stem cells in vivo.
- Loss of nuclear localized and tyrosine phosphorylated Stat5 in breast cancer predicts poor clinical outcome and increased risk of antiestrogen therapy failure.
- Non-erythroid effects of erythropoietin.
- Prolactin can modulate CD4+ T-cell response through receptor-mediated alterations in the expression of T-bet.
- Prolactin induction of insulin gene transcription: roles of glucose and signal transducer and activator of transcription 5.
- Receptors that induce erythroid differentiation of Ba/F3 cells: structural requirements and effect on STAT5 binding.
- TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth.
- The interplay of prolactin and the glucocorticoids in the regulation of beta-cell gene expression, fatty acid oxidation, and glucose-stimulated insulin secretion: implications for carbohydrate metabolism in pregnancy.
- Transcriptional Profiling of CD8+ CMV-Specific T Cell Functional Subsets Obtained Using a Modified Method for Isolating High-Quality RNA From Fixed and Permeabilized Cells.
- Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling.
-
Keywords of People
- Freemark, Michael Scott, Robert C. Atkins, M.D. and Veronica Atkins Distinguished Professor of Pediatrics, in the School of Medicine, Pediatrics, Endocrinology