Suppressor of Cytokine Signaling Proteins
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Subject Areas on Research
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ASB2α, an E3 ubiquitin ligase specificity subunit, regulates cell spreading and triggers proteasomal degradation of filamins by targeting the filamin calponin homology 1 domain.
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An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells.
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Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model.
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CIS associates with the interleukin-2 receptor beta chain and inhibits interleukin-2-dependent signaling.
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Cytokine induction of tumor necrosis factor receptor 2 is mediated by STAT3 in colon cancer cells.
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Diet-induced obese mice retain endogenous leptin action.
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Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways.
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Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I.
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IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology.
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Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma.
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Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome.
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LMP-420, a small molecular inhibitor of TNF-α, prolongs islet allograft survival by induction of suppressor of cytokine signaling-1: synergistic effect with cyclosporin-A.
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MeCP2 reinforces STAT3 signaling and the generation of effector CD4+ T cells by promoting miR-124-mediated suppression of SOCS5.
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Mutations of HNF-1beta inhibit epithelial morphogenesis through dysregulation of SOCS-3.
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Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice.
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Role for hedgehog pathway in regulating growth and function of invariant NKT cells.
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SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.
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SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro.
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SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc.
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SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling.
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Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines.
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Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors.
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Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes.
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Keywords of People