Suppressor of Cytokine Signaling Proteins
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Subject Areas on Research
- An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells.
- Diet-induced obese mice retain endogenous leptin action.
- Fill a Gab(1) in cardiac hypertrophy signaling: search a missing link between gp130 and ERK5 in hypertrophic remodeling in heart.
- Global identification of MLL2-targeted loci reveals MLL2's role in diverse signaling pathways.
- Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I.
- IL-7 engages multiple mechanisms to overcome chronic viral infection and limit organ pathology.
- Innate inhibition of adaptive immunity: Mycobacterium tuberculosis-induced IL-6 inhibits macrophage responses to IFN-gamma.
- Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome.
- LMP-420, a small molecular inhibitor of TNF-α, prolongs islet allograft survival by induction of suppressor of cytokine signaling-1: synergistic effect with cyclosporin-A.
- MeCP2 reinforces STAT3 signaling and the generation of effector CD4+ T cells by promoting miR-124-mediated suppression of SOCS5.
- Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice.
- Prolactin can modulate CD4+ T-cell response through receptor-mediated alterations in the expression of T-bet.
- Role for hedgehog pathway in regulating growth and function of invariant NKT cells.
- SOCS1, SOCS3, and PIAS1 promote myogenic differentiation by inhibiting the leukemia inhibitory factor-induced JAK1/STAT1/STAT3 pathway.
- SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro.
- SOCS36E, a novel Drosophila SOCS protein, suppresses JAK/STAT and EGF-R signalling in the imaginal wing disc.
- SPSB1 promotes breast cancer recurrence by potentiating c-MET signaling.
- Salmonella disrupts lymph node architecture by TLR4-mediated suppression of homeostatic chemokines.
- Signatures associated with rejection or recurrence in HER-2/neu-positive mammary tumors.
- Simvastatin inhibits IL-17 secretion by targeting multiple IL-17-regulatory cytokines and by inhibiting the expression of IL-17 transcription factor RORC in CD4+ lymphocytes.
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Keywords of People
- McLendon, Roger Edwin, Professor of Pathology, Pathology
- Shinohara, Mari L., Associate Professor of Immunology, Cell Biology
- Yan, Hai, Adjunct Professor of Pathology, Pathology