p300-CBP Transcription Factors

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  Subject Areas on Research

  • Acetylation of RelA at discrete sites regulates distinct nuclear functions of NF-kappaB. 
  • Assessing acetylation of NF-kappaB. 
  • Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene. 
  • Charge modification at multiple C-terminal lysine residues regulates p53 oligomerization and its nucleus-cytoplasm trafficking. 
  • Duration of nuclear NF-kappaB action regulated by reversible acetylation. 
  • HDAC6 modulates cell motility by altering the acetylation level of cortactin. 
  • HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. 
  • Intronic enhancers coordinate epithelial-specific looping of the active CFTR locus. 
  • Kruppel-like factor 15 is critical for vascular inflammation. 
  • MDM2-HDAC1-mediated deacetylation of p53 is required for its degradation. 
  • NF-κB- and AP-1-mediated DNA looping regulates osteopontin transcription in endotoxin-stimulated murine macrophages. 
  • Peptidyl-prolyl isomerase 1 (Pin1) serves as a coactivator of steroid receptor by regulating the activity of phosphorylated steroid receptor coactivator 3 (SRC-3/AIB1). 
  • Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer. 
  • Regulation of NF-kappaB action by reversible acetylation. 
  • Regulation of distinct biological activities of the NF-kappaB transcription factor complex by acetylation. 
  • VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.