E1A-Associated p300 Protein

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  Subject Areas on Research

  • A dynamic H3K27ac signature identifies VEGFA-stimulated endothelial enhancers and requires EP300 activity. 
  • A p300/GATA6 axis determines differentiation and Wnt dependency in pancreatic cancer models. 
  • CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. 
  • Cooperation of Sp1 and p300 in the induction of the CDK inhibitor p21WAF1/CIP1 during NGF-mediated neuronal differentiation. 
  • EP300-related Rubinstein-Taybi syndrome: Highlighted rare phenotypic findings and a genotype-phenotype meta-analysis of 74 patients. 
  • Effects of sequence variation on differential allelic transcription factor occupancy and gene expression. 
  • Epigenome editing by a CRISPR-Cas9-based acetyltransferase activates genes from promoters and enhancers. 
  • Expression and hormonal regulation of coactivator and corepressor genes. 
  • GREAT improves functional interpretation of cis-regulatory regions. 
  • Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. 
  • Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. 
  • Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia. 
  • Molecular and clinicopathologic characteristics of gliomas with EP300::BCOR fusions. 
  • Proteomic analysis of calcium/calmodulin-dependent protein kinase I and IV in vitro substrates reveals distinct catalytic preferences. 
  • Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. 
  • SNIP1 inhibits NF-kappa B signaling by competing for its binding to the C/H1 domain of CBP/p300 transcriptional co-activators. 
  • The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. 
  • The nuclear hormone receptor coactivator SRC-1 is a specific target of p300. 
  • p300-Mediated Lysine 2-Hydroxyisobutyrylation Regulates Glycolysis. 
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  Keywords of People

  • Reddy, Timothy E, Associate Professor of Biostatistics & Bioinformatics,, Molecular Genetics and Microbiology