CREB-Binding Protein

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  Subject Areas on Research

  • A c-Fos- and E1A-interacting component of the tissue factor basal promoter complex mediates synergistic activation of transcription by transforming growth factor-beta1. 
  • A mechanism of COOH-terminal binding protein-mediated repression. 
  • A novel TLR4-mediated signaling pathway leading to IL-6 responses in human bladder epithelial cells. 
  • A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression. 
  • Adaptor proteins in lymphocyte activation. 
  • Amphipathic small molecules mimic the binding mode and function of endogenous transcription factors. 
  • BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. 
  • CBP/p300 induction is required for retinoic acid sensitivity in human mammary cells. 
  • CREB-binding protein regulates apoptosis and growth of HMECs grown in reconstituted ECM via laminin-5. 
  • CXCL12 prolongs naive CD4+ T lymphocytes survival via activation of PKA, CREB and Bcl2 and BclXl up-regulation. 
  • Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. 
  • Case-control association study of 14 variants of CREB1, CREBBP and CREM on diagnosis and treatment outcome in major depressive disorder and bipolar disorder. 
  • Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia. 
  • CoA synthase regulates mitotic fidelity via CBP-mediated acetylation. 
  • Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. 
  • Consensus and variant cAMP-regulated enhancers have distinct CREB-binding properties. 
  • Distinct roles of the co-activators p300 and CBP in retinoic-acid-induced F9-cell differentiation. 
  • Duration of nuclear NF-kappaB action regulated by reversible acetylation. 
  • Early differential elevation and persistence of phosphorylated cAMP-response element binding protein (p-CREB) in the central nervous system of hens treated with diisopropyl phosphorofluoridate, an OPIDN-causing compound. 
  • Elevated mu-opioid receptor expression in the nucleus of the solitary tract accompanies attenuated withdrawal signs after chronic low dose naltrexone in opiate-dependent rats. 
  • Functional association of Nmi with Stat5 and Stat1 in IL-2- and IFNgamma-mediated signaling. 
  • Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. 
  • Histone deacetylase 3 binds to and regulates the GCMa transcription factor. 
  • Hormone-dependent interaction between the amino- and carboxyl-terminal domains of progesterone receptor in vitro and in vivo. 
  • Inhibition of Ca²⁺/calmodulin-dependent protein kinase kinase 2 stimulates osteoblast formation and inhibits osteoclast differentiation. 
  • Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. 
  • Interferon regulatory factor-1 regulates reconstituted extracellular matrix (rECM)-mediated apoptosis in human mammary epithelial cells. 
  • Kappa-Opioid Antagonists for Psychiatric Disorders: From Bench to Clinical Trials. 
  • Lineage-specific signaling in melanocytes. C-kit stimulation recruits p300/CBP to microphthalmia. 
  • Mutations of the Sonic Hedgehog Pathway Underlie Hypothalamic Hamartoma with Gelastic Epilepsy. 
  • Novel mutations target distinct subgroups of medulloblastoma. 
  • Nuclear protein CBP is a coactivator for the transcription factor CREB. 
  • Possible influence of CREB1, CREBBP and CREM variants on diagnosis and treatment outcome in patients with schizophrenia. 
  • Recruitment of CREB binding protein is sufficient for CREB-mediated gene activation. 
  • Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. 
  • The glucocorticoid receptor interacting protein 1 (GRIP1) localizes in discrete nuclear foci that associate with ND10 bodies and are enriched in components of the 26S proteasome. 
  • The transcriptional integrator CREB-binding protein mediates positive cross talk between nuclear hormone receptors and the hematopoietic bZip protein p45/NF-E2. 
  • Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism.