TRPV Cation Channels

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  Subject Areas on Research

  • A pH-sensitive, neurogenic pathway mediates disease severity in a model of post-ERCP pancreatitis. 
  • A possible role for TRPV4 receptors in asthma. 
  • A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. 
  • A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation. 
  • A synthetic mechanogenetic gene circuit for autonomous drug delivery in engineered tissues. 
  • Abnormal osmotic regulation in trpv4-/- mice. 
  • Acid potentiation of the capsaicin receptor determined by a key extracellular site. 
  • Agonist-dependence of functional properties for common nonsynonymous variants of human transient receptor potential vanilloid 1. 
  • Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells. 
  • Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons. 
  • Antihyperalgesic effects of vanilloid-1 and bradykinin-1 receptor antagonists following spinal cord injury in rats. 
  • Arresting a transient receptor potential (TRP) channel: beta-arrestin 1 mediates ubiquitination and functional down-regulation of TRPV4. 
  • Arterial response to shear stress critically depends on endothelial TRPV4 expression. 
  • Artificial sweeteners and salts producing a metallic taste sensation activate TRPV1 receptors. 
  • Attenuation of acid induced oesophagitis in VR-1 deficient mice. 
  • B1 and TRPV-1 receptor genes and their relationship to hyperalgesia following spinal cord injury. 
  • Breathtaking TRP channels: TRPA1 and TRPV1 in airway chemosensation and reflex control. 
  • Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium. 
  • Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis. 
  • Capsaicin, acid and heat-evoked currents in rat trigeminal ganglion neurons: relationship to functional VR1 receptors. 
  • Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis. 
  • Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4. 
  • Central opioid receptors mediate morphine-induced itch and chronic itch via disinhibition. 
  • Changes in osmolality sensitize the response to capsaicin in trigeminal sensory neurons. 
  • Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice. 
  • Combinatorial expression of TRPV channel proteins defines their sensory functions and subcellular localization in C. elegans neurons. 
  • Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. 
  • Conformational ensemble of the human TRPV3 ion channel. 
  • Conformational plasticity in the selectivity filter of the TRPV2 ion channel. 
  • Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. 
  • Cryo-electron microscopy structure of the TRPV2 ion channel. 
  • Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. 
  • Different responses to repeated applications of zingerone in behavioral studies, recordings from intact and cultured TG neurons, and from VR1 receptors. 
  • Direct In Vivo Manipulation and Imaging of Calcium Transients in Neutrophils Identify a Critical Role for Leading-Edge Calcium Flux. 
  • Drug-Inducible, Cell-Specific Manipulation of Intracellular Calcium in Zebrafish Through Mammalian TRPV1 Expression. 
  • Dual contribution of TRPV4 antagonism in the regulatory effect of vasoinhibins on blood-retinal barrier permeability: diabetic milieu makes a difference. 
  • Editorial: TRPV1: how thymocytes sense stress and respond with autophagy. 
  • Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. 
  • Emerging Role of Transient Receptor Potential Vanilloid 4 (TRPV4) Ion Channel in Acute and Chronic Itch. 
  • Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. 
  • Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity. 
  • Epithelia-Sensory Neuron Cross Talk Underlies Cholestatic Itch Induced by Lysophosphatidylcholine. 
  • Ethanol contributes to neurogenic pancreatitis by activation of TRPV1. 
  • Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. 
  • Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations. 
  • Formation of flavorant-propylene Glycol Adducts With Novel Toxicological Properties in Chemically Unstable E-Cigarette Liquids. 
  • Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate resting Ca2+ influx and muscle fatigue. 
  • Functional characterization of TRPV4 as an osmotically sensitive ion channel in porcine articular chondrocytes. 
  • Functional coupling between TRPV4 channel and TMEM16F modulates human trophoblast fusion. 
  • Functional transient receptor potential vanilloid 1 and transient receptor potential vanilloid 4 channels along different segments of the renal vasculature. 
  • Functionality of the TRPV subfamily of TRP ion channels: add mechano-TRP and osmo-TRP to the lexicon! 
  • GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice. 
  • Gustatory effects of capsaicin that are independent of TRPV1 receptors. 
  • Heat-dependent opening of TRPV1 in the presence of capsaicin. 
  • High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4. 
  • How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways. 
  • Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4. 
  • IL-23 Enhances C-Fiber-Mediated and Blue Light-Induced Spontaneous Pain in Female Mice. 
  • IL-23/IL-17A/TRPV1 axis produces mechanical pain via macrophage-sensory neuron crosstalk in female mice. 
  • Identification of a binding motif in the S5 helix that confers cholesterol sensitivity to the TRPV1 ion channel. 
  • Increased susceptibility of Trpv4-deficient mice to obesity and obesity-induced osteoarthritis with very high-fat diet. 
  • Inhibition of TRPV1 channels by a naturally occurring omega-9 fatty acid reduces pain and itch. 
  • Inhibition of the vanilloid receptor subtype-1 attenuates TNBS-colitis. 
  • Interaction between TRPV1-expressing neurons in the hypothalamus. 
  • Involvement of Sensory Neurone-TRPV4 in Acute and Chronic Itch Behaviours. 
  • Ion channels in analgesia research. 
  • Keratinocyte growth regulation TRP-ed up over downregulated TRPV4? 
  • Leukotriene B4 mediates inflammation via TRPV1 in duct obstruction-induced pancreatitis in rats. 
  • Local Peroxynitrite Impairs Endothelial Transient Receptor Potential Vanilloid 4 Channels and Elevates Blood Pressure in Obesity. 
  • Loss of endothelial CFTR drives barrier failure and edema formation in lung infection and can be targeted by CFTR potentiation. 
  • Lysophospholipids Contribute to Oxaliplatin-Induced Acute Peripheral Pain. 
  • Macrophage proresolving mediator maresin 1 stimulates tissue regeneration and controls pain. 
  • Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. 
  • Modulation of experimental arthritis by vagal sensory and central brain stimulation. 
  • Molecular Sensors of Temperature, Pressure, and Pain with Special Focus on TRPV1, TRPM8, and PIEZO2 Ion Channels. 
  • Molecular mechanisms of TRPV4-mediated neural signaling. 
  • Negative-feedback loop attenuates hydrostatic lung edema via a cGMP-dependent regulation of transient receptor potential vanilloid 4. 
  • Neurogenic inflammation and pancreatitis. 
  • Neurokinin-1 receptor enhances TRPV1 activity in primary sensory neurons via PKCepsilon: a novel pathway for heat hyperalgesia. 
  • Neutrophil Elastase Activates Protease-activated Receptor-2 (PAR2) and Transient Receptor Potential Vanilloid 4 (TRPV4) to Cause Inflammation and Pain. 
  • OnabotulinumtoxinA effects on trigeminal nociceptors. 
  • Pharmacologic disruption of TRPV1-expressing primary sensory neurons but not genetic deletion of TRPV1 protects mice against pancreatitis. 
  • Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization. 
  • Piezo1 acts upstream of TRPV4 to induce pathological changes in endothelial cells due to shear stress. 
  • Piezo1 channels mediate trabecular meshwork mechanotransduction and promote aqueous fluid outflow. 
  • Piezo1-mediated stellate cell activation causes pressure-induced pancreatic fibrosis in mice. 
  • Piezo2 mediates visceral mechanosensation: A new therapeutic target for gut pain? 
  • Pleiotropic function of TRPV4 ion channels in the central nervous system. 
  • Pore region of TRPV3 ion channel is specifically required for heat activation. 
  • Protease-activated receptor 2 (PAR2) protein and transient receptor potential vanilloid 4 (TRPV4) protein coupling is required for sustained inflammatory signaling. 
  • Protease-activated receptor 2 sensitizes the transient receptor potential vanilloid 4 ion channel to cause mechanical hyperalgesia in mice. 
  • Quantification and Potential Functions of Endogenous Agonists of Transient Receptor Potential Channels in Patients With Irritable Bowel Syndrome. 
  • Regulatory switch at the cytoplasmic interface controls TRPV channel gating. 
  • Resolvin D2 is a potent endogenous inhibitor for transient receptor potential subtype V1/A1, inflammatory pain, and spinal cord synaptic plasticity in mice: distinct roles of resolvin D1, D2, and E1. 
  • Resolving TRPV1- and TNF-α-mediated spinal cord synaptic plasticity and inflammatory pain with neuroprotectin D1. 
  • Role of TRPV ion channels in sensory transduction of osmotic stimuli in mammals. 
  • Role of Transient Receptor Potential Vanilloid 4 in Neutrophil Activation and Acute Lung Injury. 
  • SHANK3 Deficiency Impairs Heat Hyperalgesia and TRPV1 Signaling in Primary Sensory Neurons. 
  • Selective role for TRPV4 ion channels in visceral sensory pathways. 
  • Sensing hot and cold with TRP channels. 
  • Sensory Neuron-TRPV4 Modulates Temporomandibular Disorder Pain Via CGRP in Mice. 
  • Sensory attributes of complex tasting divalent salts are mediated by TRPM5 and TRPV1 channels. 
  • Single residues in the outer pore of TRPV1 and TRPV3 have temperature-dependent conformations. 
  • Skeletal dysplasia-causing TRPV4 mutations suppress the hypertrophic differentiation of human iPSC-derived chondrocytes. 
  • Skin Injury Activates a Rapid TRPV1-Dependent Antiviral Protein Response. 
  • Small molecule dual-inhibitors of TRPV4 and TRPA1 for attenuation of inflammation and pain. 
  • Social feeding in Caenorhabditis elegans is induced by neurons that detect aversive stimuli. 
  • Sustenance of endothelial cell stability in septic mice through appropriate activation of transient receptor potential vanilloid-4. 
  • Symmetry transitions during gating of the TRPV2 ion channel in lipid membranes. 
  • TLR3 deficiency impairs spinal cord synaptic transmission, central sensitization, and pruritus in mice. 
  • TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation. 
  • TRP channels in disease. 
  • TRPV channel-mediated calcium transients in nociceptor neurons are dispensable for avoidance behaviour. 
  • TRPV1 channels and the progesterone receptor Sig-1R interact to regulate pain. 
  • TRPV1 temperature activation is specifically sensitive to strong decreases in amino acid hydrophobicity. 
  • TRPV1: on the road to pain relief. 
  • TRPV1b, a functional human vanilloid receptor splice variant. 
  • TRPV4 Moves toward Center-Fold in Rosacea Pathogenesis. 
  • TRPV4 activation of endothelial nitric oxide synthase resists nonalcoholic fatty liver disease by blocking CYP2E1-mediated redox toxicity. 
  • TRPV4 as a therapeutic target for joint diseases. 
  • TRPV4 as osmosensor: a transgenic approach. 
  • TRPV4 channel contributes to serotonin-induced pulmonary vasoconstriction and the enhanced vascular reactivity in chronic hypoxic pulmonary hypertension. 
  • TRPV4 channel opening mediates pressure-induced pancreatitis initiated by Piezo1 activation. 
  • TRPV4 channel participates in receptor-operated calcium entry and ciliary beat frequency regulation in mouse airway epithelial cells. 
  • TRPV4 channels stimulate Ca2+-induced Ca2+ release in astrocytic endfeet and amplify neurovascular coupling responses. 
  • TRPV4 inhibition counteracts edema and inflammation and improves pulmonary function and oxygen saturation in chemically induced acute lung injury. 
  • TRPV4 initiates the acute calcium-dependent permeability increase during ventilator-induced lung injury in isolated mouse lungs. 
  • TRPV4 is a regulator of adipose oxidative metabolism, inflammation, and energy homeostasis. 
  • TRPV4 is necessary for trigeminal irritant pain and functions as a cellular formalin receptor. 
  • TRPV4 mediates pain-related behavior induced by mild hypertonic stimuli in the presence of inflammatory mediator. 
  • TRPV4 plays an evolutionary conserved role in the transduction of osmotic and mechanical stimuli in live animals. 
  • TRPV4-dependent dilation of peripheral resistance arteries influences arterial pressure. 
  • TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles. 
  • TRPV4-mediated calcium signaling in mesenchymal stem cells regulates aligned collagen matrix formation and vinculin tension. 
  • TRPV4-mediated mechanotransduction regulates the metabolic response of chondrocytes to dynamic loading. 
  • Tear gas: an epidemiological and mechanistic reassessment. 
  • Temperature-activated ion channels in neural crest cells confer maternal fever-associated birth defects. 
  • Temperature-induced opening of TRPV1 ion channel is stabilized by the pore domain. 
  • Temporomandibular joint pain: a critical role for Trpv4 in the trigeminal ganglion. 
  • The capsaicin receptor participates in artificial sweetener aversion. 
  • The polymodal ion channel transient receptor potential vanilloid 4 modulates calcium flux, spiking rate, and apoptosis of mouse retinal ganglion cells. 
  • The role of TRPV4 channels in cutaneous epithelia. 
  • The role of Transient Receptor Potential Vanilloid 1 (TRPV1) channels in pancreatitis. 
  • The role of endogenous molecules in modulating pain through transient receptor potential vanilloid 1 (TRPV1). 
  • The salty and burning taste of capsaicin. 
  • Transient Receptor Potential Vanilloid 4 Channel Deficiency Aggravates Tubular Damage after Acute Renal Ischaemia Reperfusion. 
  • Transient Receptor Potential Vanilloid 4 Ion Channel Functions as a Pruriceptor in Epidermal Keratinocytes to Evoke Histaminergic Itch. 
  • Transient Receptor Potential Vanilloid 4 and Serum Glucocorticoid-regulated Kinase 1 Are Critical Mediators of Lung Injury in Overventilated Mice In Vivo. 
  • Transient receptor potential (TRP) channels and taste sensation. 
  • Transient receptor potential channels in pulmonary chemical injuries and as countermeasure targets. 
  • Transient receptor potential ion channels V4 and A1 contribute to pancreatitis pain in mice. 
  • Transient receptor potential vanilloid 4 as a regulator of induced pluripotent stem cell chondrogenesis. 
  • Transient receptor potential vanilloid 4 inhibits mouse colonic motility by activating NO-dependent enteric neurotransmission. 
  • Transient receptor potential vanilloid 4-mediated disruption of the alveolar septal barrier: a novel mechanism of acute lung injury. 
  • Transient receptor potential vanilloid 4: The sixth sense of the musculoskeletal system? 
  • Transient receptor potential vanilloid channels functioning in transduction of osmotic stimuli. 
  • Transient receptor potential vanilloid-4 has a major role in visceral hypersensitivity symptoms. 
  • Trpv4 Mediates Hypotonic Inhibition of Central Osmosensory Neurons via Taurine Gliotransmission. 
  • Two amino acid residues determine 2-APB sensitivity of the ion channels TRPV3 and TRPV4. 
  • Type VI Collagen Regulates Pericellular Matrix Properties, Chondrocyte Swelling, and Mechanotransduction in Mouse Articular Cartilage. 
  • UVB radiation generates sunburn pain and affects skin by activating epidermal TRPV4 ion channels and triggering endothelin-1 signaling. 
  • Upregulation of osmo-mechanosensitive TRPV4 channel facilitates chronic hypoxia-induced myogenic tone and pulmonary hypertension. 
  • Urgent reconsideration of lung edema as a preventable outcome in COVID-19: inhibition of TRPV4 represents a promising and feasible approach. 
  • Vanilloid receptor-1 containing primary sensory neurones mediate dextran sulphate sodium induced colitis in rats. 
  • Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. 
  • ΔN-TRPV1: A Molecular Co-detector of Body Temperature and Osmotic Stress. 
  • β-Arrestin-2 desensitizes the transient receptor potential vanilloid 1 (TRPV1) channel. 
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  Keywords of People

  • Jabba, Sairam V., Research Scientist, Anesthesiology
  • Jokerst, Nan Marie, J. A. Jones Distinguished Professor of Electrical and Computer Engineering, Nicholas Institute-Energy Initiative
  • Jordt, Sven Eric, Associate Professor in Anesthesiology, Pharmacology & Cancer Biology