GATA4 Transcription Factor
Subject Areas on Research
- Defects of the heart, eye, and megakaryocytes in peroxisome proliferator activator receptor-binding protein (PBP) null embryos implicate GATA family of transcription factors.
- Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm.
- Electrical stimulation of neonatal cardiac myocytes activates the NFAT3 and GATA4 pathways and up-regulates the adenylosuccinate synthetase 1 gene.
- Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation.
- Estrogen represses SOX9 during sex determination in the red-eared slider turtle Trachemys scripta.
- GATA4 and the two sides of gene expression reprogramming.
- Induced cardiomyocyte maturation: Cardiac transcription factors are necessary but not sufficient.
- Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5.
- Regulatory crosstalk between lineage-survival oncogenes KLF5, GATA4 and GATA6 cooperatively promotes gastric cancer development.
- Sp and GATA factors are critical for Apolipoprotein AI downstream enhancer activity in human HepG2 cells.
- Stoichiometry of Gata4, Mef2c, and Tbx5 influences the efficiency and quality of induced cardiac myocyte reprogramming.
- TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure.
- The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy.
- Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming.
- Tumor Suppressors RB1 and CDKN2a Cooperatively Regulate Cell-Cycle Progression and Differentiation During Cardiomyocyte Development and Repair.
Keywords of People
- Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology