Apoptosis Regulatory Proteins

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  Subject Areas on Research

  • A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease. 
  • A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer. 
  • A loss-of-function RNA interference screen for molecular targets in cancer. 
  • A new face on apoptosis: death-associated protein 3 and PDCD9 are mitochondrial ribosomal proteins. 
  • A novel BIM deletion polymorphism: implications and lessons for cancer targeted therapies. 
  • A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO. 
  • A role of the CTCF binding site at enhancer Eα in the dynamic chromatin organization of the Tcra-Tcrd locus. 
  • A solubility-enhancement tag (SET) for NMR studies of poorly behaving proteins. 
  • A unique role of the DNA fragmentation factor in maintaining genomic stability. 
  • Aberrant promoter methylation of multiple genes in non-small cell lung cancers. 
  • Acquisition of mitochondrial dysregulation and resistance to mitochondrial-mediated apoptosis after genotoxic insult in normal human fibroblasts: a possible model for early stage carcinogenesis. 
  • Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. 
  • Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. 
  • Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells. 
  • Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. 
  • Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner. 
  • Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals. 
  • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. 
  • Autophagy links inflammasomes to atherosclerotic progression. 
  • Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis. 
  • Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. 
  • Autophagy: not good OR bad, but good AND bad. 
  • Aven-dependent activation of ATM following DNA damage. 
  • BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy. 
  • BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma. 
  • Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis. 
  • Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes. 
  • CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression. 
  • Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling. 
  • Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. 
  • Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis. 
  • Cell death-stimulated cell proliferation: a tissue regeneration mechanism usurped by tumors during radiotherapy. 
  • Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells. 
  • Citrus CsACD2 Is a Target of Candidatus Liberibacter Asiaticus in Huanglongbing Disease. 
  • Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells. 
  • Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice. 
  • Consortium analysis of 7 candidate SNPs for ovarian cancer. 
  • Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. 
  • Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. 
  • Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. 
  • Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases. 
  • Different spectra of genomic deletions within the CCM genes between Italian and American CCM patient cohorts. 
  • Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines. 
  • Differential requirements for NAIP5 in activation of the NLRC4 inflammasome. 
  • Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes. 
  • Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation. 
  • Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2. 
  • Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin. 
  • Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase. 
  • ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms. 
  • EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity. 
  • Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms. 
  • Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2. 
  • Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes. 
  • Epidermal growth factor regulates hematopoietic regeneration after radiation injury. 
  • Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer. 
  • Evidence that Par-4 participates in the pathogenesis of HIV encephalitis. 
  • Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. 
  • Expression level is a key determinant of E2F1-mediated cell fate. 
  • Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers. 
  • Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition. 
  • Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. 
  • Functional variants in TNFAIP8 associated with cervical cancer susceptibility and clinical outcomes. 
  • GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways. 
  • GW112, a novel antiapoptotic protein that promotes tumor growth. 
  • Gene expression patterns that characterize advanced stage serous ovarian cancers. 
  • Generation of a Listeria vaccine strain by enhanced caspase-1 activation. 
  • Genetic variants of a BH3-only pro-apoptotic gene, PUMA, and risk of HPV16-associated squamous cell carcinoma of the head and neck. 
  • Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer. 
  • Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage. 
  • Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. 
  • Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation. 
  • Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis. 
  • Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis. 
  • Heritable resistance to tyrosine kinase inhibitors. 
  • High expression of tumor necrosis factor-related apoptosis-inducing ligand is associated with favorable ovarian cancer survival. 
  • Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1. 
  • Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes. 
  • IKKα negatively regulates ASC-dependent inflammasome activation. 
  • Identification of cis-acting elements and splicing factors involved in the regulation of BIM Pre-mRNA splicing. 
  • Identification of the endogenous smooth muscle myosin phosphatase-associated kinase. 
  • Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium. 
  • Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies. 
  • Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II. 
  • Inhibitor of apoptosis proteins as intracellular signaling intermediates. 
  • Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome. 
  • Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome. 
  • Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation. 
  • Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer. 
  • Knockdown of mouse VCAM-1 by vector-based siRNA. 
  • Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death. 
  • Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis. 
  • Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection. 
  • Low frequency of PDCD10 mutations in a panel of CCM3 probands: potential for a fourth CCM locus. 
  • Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut. 
  • MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch. 
  • Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2. 
  • Mechanisms of NOD-like receptor-associated inflammasome activation. 
  • Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia. 
  • Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease. 
  • Mitochondrial dysfunction in ataxia-telangiectasia. 
  • Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes. 
  • Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78. 
  • Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family. 
  • Multi-agent chemotherapy overcomes glucocorticoid resistance conferred by a BIM deletion polymorphism in pediatric acute lymphoblastic leukemia. 
  • Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. 
  • Murine Irgm Paralogs Regulate Nonredundant Functions To Execute Host Defense to Toxoplasma gondii. 
  • Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy. 
  • NAIP inflammasomes give the NOD to bacterial ligands. 
  • NLRC4 and TLR5 each contribute to host defense in respiratory melioidosis. 
  • NLRP1 - One NLR to guard them all. 
  • Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium. 
  • Newborns of obese parents have altered DNA methylation patterns at imprinted genes. 
  • Novel Murine Models of Cerebral Cavernous Malformations. 
  • Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling. 
  • On the TRAIL from p53 to apoptosis? 
  • Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. 
  • Overexpressed BAG3 is a potential therapeutic target in chronic lymphocytic leukemia. 
  • PFT-alpha inhibits antibody-induced activation of p53 and pro-apoptotic signaling in 1-LN prostate cancer cells. 
  • PGC1-α over-expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice. 
  • Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy. 
  • Phenotypic characterization of murine models of cerebral cavernous malformations. 
  • Phosphorylation-dependent control of ZIPK nuclear import is species specific. 
  • Pilot and feasibility study: prospective proteomic profiling of mammary epithelial cells from high-risk women provides evidence of activation of pro-survival pathways. 
  • Poxvirus tumor necrosis factor receptor (TNFR)-like T2 proteins contain a conserved preligand assembly domain that inhibits cellular TNFR1-induced cell death. 
  • Precision Medicine for Heart Failure: Lessons From Oncology. 
  • Preclinical evaluation of a regimen combining chidamide and ABT-199 in acute myeloid leukemia. 
  • Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis. 
  • Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target. 
  • Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models. 
  • Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network. 
  • Proteomic analysis of the luteal endometrial secretome. 
  • Proteomic identification of the cerebral cavernous malformation signaling complex. 
  • Pseudomonas aeruginosa activates caspase 1 through Ipaf. 
  • ROCK1 phosphorylates and activates zipper-interacting protein kinase. 
  • Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes. 
  • Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation. 
  • Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export. 
  • Reply: the BIM deletion polymorphism cannot account for intrinsic TKI resistance of Chinese individuals with chronic myeloid leukemia. 
  • Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways. 
  • Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO. 
  • Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease. 
  • Single-walled carbon nanotubes increase pandemic influenza A H1N1 virus infectivity of lung epithelial cells. 
  • Skeletal muscle protein synthesis and the abundance of the mRNA translation initiation repressor PDCD4 are inversely regulated by fasting and refeeding in rats. 
  • Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism. 
  • Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins. 
  • Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition. 
  • Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides. 
  • Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45. 
  • Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis. 
  • Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB. 
  • Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3). 
  • Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant. 
  • Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection. 
  • TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system. 
  • TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure. 
  • The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia. 
  • The C-terminal domain of viral IAP associated factor (cVIAF) is a structural homologue of phosducin: resonance assignments and secondary structure of the C-terminal domain of VIAF. 
  • The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast. 
  • The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer. 
  • The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis. 
  • The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation. 
  • The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1. 
  • The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression. 
  • The crosstalk between autophagy and apoptosis: where does this lead? 
  • The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways. 
  • The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis. 
  • The role of Bcl-xL in mouse RPE cell survival. 
  • The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3. 
  • Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells. 
  • Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations. 
  • Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity. 
  • Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling. 
  • Truncating variants in p53AIP1 disrupting DNA damage-induced apoptosis are associated with prostate cancer risk. 
  • Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study. 
  • Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses. 
  • Upstream regulatory role for XIAP in receptor-mediated apoptosis. 
  • VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation. 
  • Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase. 
  • Whole exome sequencing identifies a mutation for a novel form of corneal intraepithelial dyskeratosis. 
  • X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells. 
  • X-ray irradiation induced Disabled-2 gene promoter de-methylation enhances radiosensitivity of non-small-cell lung carcinoma cells. 
  • XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis. 
  • Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP. 
  • ZIP kinase, a key regulator of myosin protein phosphatase 1. 
  • c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway. 
  • miR-21 improves the neurological outcome after traumatic brain injury in rats. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
  • Moorman, Patricia Gripka, Professor Emeritus in Family Medicine and Community Health, Duke Cancer Institute
  • Taylor, Gregory Alan, Professor in Medicine, Immunology