Apoptosis Regulatory Proteins
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Subject Areas on Research
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A Brain-Targeted Orally Available ROCK2 Inhibitor Benefits Mild and Aggressive Cavernous Angioma Disease.
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A common BIM deletion polymorphism mediates intrinsic resistance and inferior responses to tyrosine kinase inhibitors in cancer.
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A loss-of-function RNA interference screen for molecular targets in cancer.
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A new face on apoptosis: death-associated protein 3 and PDCD9 are mitochondrial ribosomal proteins.
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A novel BIM deletion polymorphism: implications and lessons for cancer targeted therapies.
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A novel ubiquitin fusion system bypasses the mitochondria and generates biologically active Smac/DIABLO.
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A role of the CTCF binding site at enhancer Eα in the dynamic chromatin organization of the Tcra-Tcrd locus.
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A solubility-enhancement tag (SET) for NMR studies of poorly behaving proteins.
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A unique role of the DNA fragmentation factor in maintaining genomic stability.
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Aberrant promoter methylation of multiple genes in non-small cell lung cancers.
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Acquisition of mitochondrial dysregulation and resistance to mitochondrial-mediated apoptosis after genotoxic insult in normal human fibroblasts: a possible model for early stage carcinogenesis.
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Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.
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Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.
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Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells.
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Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP.
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Apoptotic DNA fragmentation factor maintains chromosome stability in a P53-independent manner.
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Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals.
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Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages.
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Autophagy links inflammasomes to atherosclerotic progression.
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Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis.
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Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide.
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Autophagy: not good OR bad, but good AND bad.
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Aven-dependent activation of ATM following DNA damage.
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BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy.
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BCL2 translocation defines a unique tumor subset within the germinal center B-cell-like diffuse large B-cell lymphoma.
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Biallelic somatic and germline mutations in cerebral cavernous malformations (CCMs): evidence for a two-hit mechanism of CCM pathogenesis.
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Brain control of blood glucose levels: implications for the pathogenesis of type 2 diabetes.
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CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression.
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Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling.
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Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria.
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Caspase-8-mediated PAR-4 cleavage is required for TNFα-induced apoptosis.
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Cell death-stimulated cell proliferation: a tissue regeneration mechanism usurped by tumors during radiotherapy.
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Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells.
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Citrus CsACD2 Is a Target of Candidatus
Liberibacter Asiaticus in Huanglongbing Disease.
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Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells.
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Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice.
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Consortium analysis of 7 candidate SNPs for ovarian cancer.
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Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2.
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Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock.
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Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf.
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Deciphering the signaling networks underlying simvastatin-induced apoptosis in human cancer cells: evidence for non-canonical activation of RhoA and Rac1 GTPases.
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Different spectra of genomic deletions within the CCM genes between Italian and American CCM patient cohorts.
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Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines.
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Differential requirements for NAIP5 in activation of the NLRC4 inflammasome.
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Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes.
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Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation.
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Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2.
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Downregulation of the proapoptotic protein MOAP-1 by the UBR5 ubiquitin ligase and its role in ovarian cancer resistance to cisplatin.
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Dual Ser and Thr phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by MYPT-associated kinase.
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ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms.
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EGFR and EGFRvIII interact with PUMA to inhibit mitochondrial translocalization of PUMA and PUMA-mediated apoptosis independent of EGFR kinase activity.
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Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.
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Enhanced cytoprotective effects of the inhibitor of apoptosis protein cellular IAP1 through stabilization with TRAF2.
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Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes.
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Epidermal growth factor regulates hematopoietic regeneration after radiation injury.
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Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer.
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Evidence that Par-4 participates in the pathogenesis of HIV encephalitis.
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Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations.
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Expression level is a key determinant of E2F1-mediated cell fate.
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Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers.
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Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition.
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Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death.
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Functional variants in TNFAIP8 associated with cervical cancer susceptibility and clinical outcomes.
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GAIP interacting protein C-terminus regulates autophagy and exosome biogenesis of pancreatic cancer through metabolic pathways.
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GW112, a novel antiapoptotic protein that promotes tumor growth.
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Gene expression patterns that characterize advanced stage serous ovarian cancers.
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Generation of a Listeria vaccine strain by enhanced caspase-1 activation.
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Genetic variants of a BH3-only pro-apoptotic gene, PUMA, and risk of HPV16-associated squamous cell carcinoma of the head and neck.
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Genomic loss of miR-486 regulates tumor progression and the OLFM4 antiapoptotic factor in gastric cancer.
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Gfi-1B controls human erythroid and megakaryocytic differentiation by regulating TGF-beta signaling at the bipotent erythro-megakaryocytic progenitor stage.
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Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors.
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Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation.
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Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis.
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Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis.
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Heritable resistance to tyrosine kinase inhibitors.
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High expression of tumor necrosis factor-related apoptosis-inducing ligand is associated with favorable ovarian cancer survival.
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Human Bcl-2 cannot directly inhibit the Caenorhabditis elegans Apaf-1 homologue CED-4, but can interact with EGL-1.
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Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.
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IKKα negatively regulates ASC-dependent inflammasome activation.
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Identification of cis-acting elements and splicing factors involved in the regulation of BIM Pre-mRNA splicing.
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Identification of the endogenous smooth muscle myosin phosphatase-associated kinase.
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Inflammasomes Coordinate Pyroptosis and Natural Killer Cell Cytotoxicity to Clear Infection by a Ubiquitous Environmental Bacterium.
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Inflammatory breast cancer tumor emboli express high levels of anti-apoptotic proteins: use of a quantitative high content and high-throughput 3D IBC spheroid assay to identify targeting strategies.
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Inherited human Caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II.
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Inhibitor of apoptosis proteins as intracellular signaling intermediates.
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Innate immune detection of the type III secretion apparatus through the NLRC4 inflammasome.
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Interferon-β therapy against EAE is effective only when development of the disease depends on the NLRP3 inflammasome.
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Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation.
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Isorhamnetin inhibits proliferation and invasion and induces apoptosis through the modulation of peroxisome proliferator-activated receptor γ activation pathway in gastric cancer.
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Knockdown of mouse VCAM-1 by vector-based siRNA.
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Lack of p38 MAP kinase activation in TRAIL-resistant cells is not related to the resistance to TRAIL-mediated cell death.
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Lesions from patients with sporadic cerebral cavernous malformations harbor somatic mutations in the CCM genes: evidence for a common biochemical pathway for CCM pathogenesis.
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Loss of DNAM-1 contributes to CD8+ T-cell exhaustion in chronic HIV-1 infection.
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Low frequency of PDCD10 mutations in a panel of CCM3 probands: potential for a fourth CCM locus.
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Lysosome-Rich Enterocytes Mediate Protein Absorption in the Vertebrate Gut.
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MTOR-independent induction of autophagy in trabecular meshwork cells subjected to biaxial stretch.
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Mcl-1 promotes survival of thymocytes by inhibition of Bak in a pathway separate from Bcl-2.
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Mechanisms of NOD-like receptor-associated inflammasome activation.
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Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia.
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Micro-computed tomography in murine models of cerebral cavernous malformations as a paradigm for brain disease.
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Mitochondrial dysfunction in ataxia-telangiectasia.
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Mitochondrial dysfunction in human immunodeficiency virus-1 transgenic mouse cardiac myocytes.
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Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78.
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Molecular cloning of ILP-2, a novel member of the inhibitor of apoptosis protein family.
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Multi-agent chemotherapy overcomes glucocorticoid resistance conferred by a BIM deletion polymorphism in pediatric acute lymphoblastic leukemia.
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Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection.
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Murine Irgm Paralogs Regulate Nonredundant Functions To Execute Host Defense to Toxoplasma gondii.
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Mutations affecting the cytoplasmic functions of the co-chaperone DNAJB6 cause limb-girdle muscular dystrophy.
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NAIP inflammasomes give the NOD to bacterial ligands.
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NLRC4 and TLR5 each contribute to host defense in respiratory melioidosis.
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NLRP1 - One NLR to guard them all.
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Neutrophil Caspase-11 Is Essential to Defend against a Cytosol-Invasive Bacterium.
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Newborns of obese parents have altered DNA methylation patterns at imprinted genes.
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Novel Murine Models of Cerebral Cavernous Malformations.
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Novel role of 4-hydroxy-2-nonenal in AIFm2-mediated mitochondrial stress signaling.
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On the TRAIL from p53 to apoptosis?
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Oncogenic CARD11 mutations in human diffuse large B cell lymphoma.
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Overexpressed BAG3 is a potential therapeutic target in chronic lymphocytic leukemia.
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PFT-alpha inhibits antibody-induced activation of p53 and pro-apoptotic signaling in 1-LN prostate cancer cells.
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PGC1-α over-expression prevents metabolic alterations and soleus muscle atrophy in hindlimb unloaded mice.
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Par-4 downregulation promotes breast cancer recurrence by preventing multinucleation following targeted therapy.
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Phenotypic characterization of murine models of cerebral cavernous malformations.
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Phosphorylation-dependent control of ZIPK nuclear import is species specific.
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Pilot and feasibility study: prospective proteomic profiling of mammary epithelial cells from high-risk women provides evidence of activation of pro-survival pathways.
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Poxvirus tumor necrosis factor receptor (TNFR)-like T2 proteins contain a conserved preligand assembly domain that inhibits cellular TNFR1-induced cell death.
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Precision Medicine for Heart Failure: Lessons From Oncology.
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Preclinical evaluation of a regimen combining chidamide and ABT-199 in acute myeloid leukemia.
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Preligand assembly domain-mediated ligand-independent association between TRAIL receptor 4 (TR4) and TR2 regulates TRAIL-induced apoptosis.
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Profiling microRNA expression in hepatocellular carcinoma reveals microRNA-224 up-regulation and apoptosis inhibitor-5 as a microRNA-224-specific target.
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Propranolol inhibits cavernous vascular malformations by β1 adrenergic receptor antagonism in animal models.
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Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.
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Proteomic analysis of the luteal endometrial secretome.
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Proteomic identification of the cerebral cavernous malformation signaling complex.
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Pseudomonas aeruginosa activates caspase 1 through Ipaf.
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ROCK1 phosphorylates and activates zipper-interacting protein kinase.
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Regulation of death-associated protein kinase. Stabilization by HSP90 heterocomplexes.
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Regulation of mammalian horizontal gene transfer by apoptotic DNA fragmentation.
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Regulation of the ATM-activator protein Aven by CRM1-dependent nuclear export.
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Reply: the BIM deletion polymorphism cannot account for intrinsic TKI resistance of Chinese individuals with chronic myeloid leukemia.
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Restriction of Legionella pneumophila growth in macrophages requires the concerted action of cytokine and Naip5/Ipaf signalling pathways.
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Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO.
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Rho Kinase Inhibition Blunts Lesion Development and Hemorrhage in Murine Models of Aggressive Pdcd10/Ccm3 Disease.
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Single-walled carbon nanotubes increase pandemic influenza A H1N1 virus infectivity of lung epithelial cells.
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Skeletal muscle protein synthesis and the abundance of the mRNA translation initiation repressor PDCD4 are inversely regulated by fasting and refeeding in rats.
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Smac mimetic Birinapant induces apoptosis and enhances TRAIL potency in inflammatory breast cancer cells in an IAP-dependent and TNF-α-independent mechanism.
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Smac/Diablo antagonizes ubiquitin ligase activity of inhibitor of apoptosis proteins.
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Smooth muscle myosin phosphatase-associated kinase induces Ca2+ sensitization via myosin phosphatase inhibition.
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Smooth muscle phosphatase is regulated in vivo by exclusion of phosphorylation of threonine 696 of MYPT1 by phosphorylation of Serine 695 in response to cyclic nucleotides.
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Solution structure of DFF40 and DFF45 N-terminal domain complex and mutual chaperone activity of DFF40 and DFF45.
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Solution structure of the CIDE-N domain of CIDE-B and a model for CIDE-N/CIDE-N interactions in the DNA fragmentation pathway of apoptosis.
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Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB.
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Studies on the interaction between TWEAK and the death receptor WSL-1/TRAMP (DR3).
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Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant.
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Surface expression patterns of negative regulatory molecules identify determinants of virus-specific CD8+ T-cell exhaustion in HIV infection.
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TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system.
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TRIM35-mediated degradation of nuclear PKM2 destabilizes GATA4/6 and induces P53 in cardiomyocytes to promote heart failure.
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The BIM deletion polymorphism: A paradigm of a permissive interaction between germline and acquired TKI resistance factors in chronic myeloid leukemia.
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The C-terminal domain of viral IAP associated factor (cVIAF) is a structural homologue of phosducin: resonance assignments and secondary structure of the C-terminal domain of VIAF.
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The Caenorhabditis elegans CED-9 protein does not directly inhibit the caspase CED-3, in vitro nor in yeast.
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The NLRP3 inflammasome functions as a negative regulator of tumorigenesis during colitis-associated cancer.
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The NLRP3 inflammasome protects against loss of epithelial integrity and mortality during experimental colitis.
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The Prostaglandin E2-EP3 Receptor Axis Regulates Anaplasma phagocytophilum-Mediated NLRC4 Inflammasome Activation.
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The Trim39 ubiquitin ligase inhibits APC/CCdh1-mediated degradation of the Bax activator MOAP-1.
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The class III kinase Vps34 promotes T lymphocyte survival through regulating IL-7Rα surface expression.
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The crosstalk between autophagy and apoptosis: where does this lead?
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The histone deacetylase inhibitor trichostatin a decreases lymphangiogenesis by inducing apoptosis and cell cycle arrest via p21-dependent pathways.
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The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis.
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The role of Bcl-xL in mouse RPE cell survival.
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The small heat shock protein alpha B-crystallin is a novel inhibitor of TRAIL-induced apoptosis that suppresses the activation of caspase-3.
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Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells.
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Transcriptome clarifies mechanisms of lesion genesis versus progression in models of Ccm3 cerebral cavernous malformations.
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Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity.
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Transient CD86 expression on hepatitis C virus-specific CD8+ T cells in acute infection is linked to sufficient IL-2 signaling.
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Truncating variants in p53AIP1 disrupting DNA damage-induced apoptosis are associated with prostate cancer risk.
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Tumor necrosis factor-α induced protein 8 polymorphism and risk of non-Hodgkin's lymphoma in a Chinese population: a case-control study.
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Two genes on A/J chromosome 18 are associated with susceptibility to Staphylococcus aureus infection by combined microarray and QTL analyses.
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Upstream regulatory role for XIAP in receptor-mediated apoptosis.
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VIAF, a conserved inhibitor of apoptosis (IAP)-interacting factor that modulates caspase activation.
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Vitamin D inhibits proliferation of human uterine leiomyoma cells via catechol-O-methyltransferase.
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Whole exome sequencing identifies a mutation for a novel form of corneal intraepithelial dyskeratosis.
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X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells.
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X-ray irradiation induced Disabled-2 gene promoter de-methylation enhances radiosensitivity of non-small-cell lung carcinoma cells.
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XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis.
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Xaf1 can cooperate with TNFalpha in the induction of apoptosis, independently of interaction with XIAP.
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ZIP kinase, a key regulator of myosin protein phosphatase 1.
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c-FLIP protects T lymphocytes from apoptosis in the intrinsic pathway.
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miR-21 improves the neurological outcome after traumatic brain injury in rats.
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Keywords of People
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Berchuck, Andrew,
James M. Ingram Distinguished Professor of Gynecologic Oncology,
Obstetrics and Gynecology, Gynecologic Oncology
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Ferrari, Guido,
Professor in Surgery,
Molecular Genetics and Microbiology
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Moorman, Patricia Gripka,
Professor Emeritus in Family Medicine and Community Health,
Duke Cancer Institute
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Taylor, Gregory Alan,
Professor in Medicine,
Immunology