bcl-X Protein
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Subject Areas on Research
- A GH3-like domain in reaper is required for mitochondrial localization and induction of IAP degradation.
- A novel approach for characterizing protein ligand complexes: molecular basis for specificity of small-molecule Bcl-2 inhibitors.
- A pathway of neuronal apoptosis induced by hypoxia/reoxygenation: roles of nuclear factor-kappaB and Bcl-2.
- Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl.
- Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology.
- Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells.
- Apoptosis and B cell tolerance.
- Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis.
- Bcl-xL is an oncogenic driver in colorectal cancer.
- CXCL12 prolongs naive CD4+ T lymphocytes survival via activation of PKA, CREB and Bcl2 and BclXl up-regulation.
- Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells.
- Caspase activation and amyloid precursor protein cleavage in rat ocular hypertension.
- Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model.
- Cytoprotective effects of IAPs revealed by a small molecule antagonist.
- Delayed myocardial preconditioning by alpha1-adrenoceptors involves inhibition of apoptosis.
- Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses.
- FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma.
- Failure to induce apoptosis via BCL-2 family proteins underlies lack of efficacy of combined MEK and PI3K inhibitors for KRAS-mutant lung cancers.
- Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation.
- First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.
- Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models.
- Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells.
- H/D exchange- and mass spectrometry-based strategy for the thermodynamic analysis of protein-ligand binding.
- Human IAP-like protein regulates programmed cell death downstream of Bcl-xL and cytochrome c.
- Human RPE expression of cell survival factors.
- IL-15 regulates homeostasis and terminal maturation of NKT cells.
- In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability.
- In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer.
- In vitro interleukin-6 treatment prevents mortality associated with fatty liver transplants in rats.
- Inhibition of apoptotic signaling and neointimal hyperplasia by tempol and nitric oxide synthase following vascular injury.
- Inhibition of constitutive NF-kappa B activity by I kappa B alpha M suppresses tumorigenesis.
- Intracellular BH3 Profiling Reveals Shifts in Antiapoptotic Dependency in Human B Cell Maturation and Mitogen-Stimulated Proliferation.
- Isolation of unique STAT5 targets by chromatin immunoprecipitation-based gene identification.
- Low K+ promotes NF-kappaB/DNA binding in neuronal apoptosis induced by K+ loss.
- Melanoma proliferation and chemoresistance controlled by the DEK oncogene.
- Metabolic regulation of protein N-alpha-acetylation by Bcl-xL promotes cell survival.
- Modulation of cell death by Bcl-XL through caspase interaction.
- Modulation of cytokine-induced cardiac myocyte apoptosis by nitric oxide, Bak, and Bcl-x.
- Mutation of bcl-x gene in non-Hodgkin's lymphoma.
- Orphan nuclear receptors in T lymphocyte development.
- PIK3CA mutations enable targeting of a breast tumor dependency through mTOR-mediated MCL-1 translation.
- PRKACA mediates resistance to HER2-targeted therapy in breast cancer cells and restores anti-apoptotic signaling.
- Protein phosphatase 2A activates the proapoptotic function of BAD in interleukin- 3-dependent lymphoid cells by a mechanism requiring 14-3-3 dissociation.
- Protein phosphatase 2A dephosphorylation of phosphoserine 112 plays the gatekeeper role for BAD-mediated apoptosis.
- RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.
- Regulation of the TCRalpha repertoire by the survival window of CD4(+)CD8(+) thymocytes.
- Relaxed negative selection in germinal centers and impaired affinity maturation in bcl-xL transgenic mice.
- Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction.
- Synthetic lethal interaction of combined BCL-XL and MEK inhibition promotes tumor regressions in KRAS mutant cancer models.
- Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1.
- Systematic mapping of BCL-2 gene dependencies in cancer reveals molecular determinants of BH3 mimetic sensitivity.
- Targeting BCL-2 with venetoclax and dexamethasone in patients with relapsed/refractory t(11;14) multiple myeloma.
- Targeting MCL-1/BCL-XL Forestalls the Acquisition of Resistance to ABT-199 in Acute Myeloid Leukemia.
- The anti-apoptotic Bcl-2 family member Mcl-1 promotes T lymphocyte survival at multiple stages.
- The antiapoptotic protein Bcl-xL is dispensable for the development of effector and memory T lymphocytes.
- The antiapoptotic protein Mcl-1 is essential for the survival of neutrophils but not macrophages.
- The function of multiple IkappaB : NF-kappaB complexes in the resistance of cancer cells to Taxol-induced apoptosis.
- The importance of Bcl-xL in the survival of human RPE cells.
- The role of Bcl-xL in mouse RPE cell survival.
- Tyrosine kinase ETK/BMX is up-regulated in bladder cancer and predicts poor prognosis in patients with cystectomy.
- Upstream regulatory role for XIAP in receptor-mediated apoptosis.
- mTOR inhibition specifically sensitizes colorectal cancers with KRAS or BRAF mutations to BCL-2/BCL-XL inhibition by suppressing MCL-1.