Sphingosine N-Acyltransferase

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  Subject Areas on Research

  • CLN5 and CLN8 protein association with ceramide synthase: biochemical and proteomic approaches. 
  • CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. 
  • Enzymes of ceramide biosynthesis. 
  • Expression of ceramide-metabolising enzymes in subcutaneous and intra-abdominal human adipose tissue. 
  • Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. 
  • Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme. 
  • Two mammalian longevity assurance gene (LAG1) family members, trh1 and trh4, regulate dihydroceramide synthesis using different fatty acyl-CoA donors.