Proto-Oncogene Proteins c-akt
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Subject Areas on Research
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A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice.
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A Functional Polymorphism (rs2494752) in the AKT1 Promoter Region and Gastric Adenocarcinoma Risk in an Eastern Chinese Population.
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A Low-Frequency Inactivating AKT2 Variant Enriched in the Finnish Population Is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
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A VEGF trap inhibits the beneficial effect of bFGF on vasoreactivity in corporal tissues of hypercholesterolemic rabbits.
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A beta-arrestin 2 signaling complex mediates lithium action on behavior.
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A constitutively active form of neurokinin 1 receptor and neurokinin 1 receptor-mediated apoptosis in glioblastomas.
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A crucial role for GRK2 in regulation of endothelial cell nitric oxide synthase function in portal hypertension.
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A differential role for endocytosis in receptor-mediated activation of Nox1.
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A genomic approach to identify molecular pathways associated with chemotherapy resistance.
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A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice.
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A new activating role for CO in cardiac mitochondrial biogenesis.
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A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase.
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A novel classification of lung cancer into molecular subtypes.
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A nuclease-resistant RNA aptamer specifically inhibits angiopoietin-1-mediated Tie2 activation and function.
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A phase II study of isoflavones, erlotinib, and gemcitabine in advanced pancreatic cancer.
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A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1.
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AKT Hyperactivation and the Potential of AKT-Targeted Therapy in Diffuse Large B-Cell Lymphoma.
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AKT-independent signaling downstream of oncogenic PIK3CA mutations in human cancer.
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AKT1 and neurocognition in schizophrenia.
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AKT1 gene mutation levels are correlated with the type of dermatologic lesions in patients with Proteus syndrome.
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AKT1 mediates bypass of the G1/S checkpoint after genotoxic stress in normal human cells.
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AKT1 polymorphisms are associated with risk for metabolic syndrome.
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APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt Pathway via the phosphoinositol phosphatase SHIP2.
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Abi3bp is a multifunctional autocrine/paracrine factor that regulates mesenchymal stem cell biology.
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Abi3bp regulates cardiac progenitor cell proliferation and differentiation.
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Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling.
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Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma.
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Activated forms of H-RAS and K-RAS differentially regulate membrane association of PI3K, PDK-1, and AKT and the effect of therapeutic kinase inhibitors on cell survival.
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Activated α2-macroglobulin binding to cell surface GRP78 induces T-loop phosphorylation of Akt1 by PDK1 in association with Raptor.
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Activation and cross-talk between Akt, NF-kappaB, and unfolded protein response signaling in 1-LN prostate cancer cells consequent to ligation of cell surface-associated GRP78.
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Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene.
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Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer.
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Activation of the PKB/Akt pathway in histological benign prostatic tissue adjacent to the primary malignant lesions.
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Activator protein-1 has an essential role in pancreatic cancer cells and is regulated by a novel Akt-mediated mechanism.
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Afatinib induces apoptosis in NSCLC without EGFR mutation through Elk-1-mediated suppression of CIP2A.
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Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53.
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Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology.
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Akt expression may predict favorable prognosis in cholangiocarcinoma.
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Akt is required for Stat5 activation and mammary differentiation.
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Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells.
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Akt signalling through GSK-3beta, mTOR and Foxo1 is involved in human skeletal muscle hypertrophy and atrophy.
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Akt-dependent and -independent mechanisms of mTOR regulation in cancer.
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Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition.
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Akt/protein kinase B is constitutively active in non-small cell lung cancer cells and promotes cellular survival and resistance to chemotherapy and radiation.
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Akt/protein kinase B promotes organ growth in transgenic mice.
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Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation.
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Akt1 and Akt2 promote peripheral B-cell maturation and survival.
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Akt1 deletion prevents lung tumorigenesis by mutant K-ras.
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Alkylation of the tumor suppressor PTEN activates Akt and β-catenin signaling: a mechanism linking inflammation and oxidative stress with cancer.
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An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior.
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An endothelial TLR4-VEGFR2 pathway mediates lung protection against oxidant-induced injury.
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An heregulin-EGFR-HER3 autocrine signaling axis can mediate acquired lapatinib resistance in HER2+ breast cancer models.
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Anti-fibrotic effects of different sources of MSC in bleomycin-induced lung fibrosis in C57BL6 male mice.
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Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma.
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Apoptosis and B cell tolerance.
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Application of oligonucleotide microarrays to assess the biological effects of neoadjuvant imatinib mesylate treatment for localized prostate cancer.
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Arsenic trioxide synergizes with everolimus (Rad001) to induce cytotoxicity of ovarian cancer cells through increased autophagy and apoptosis.
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Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways.
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BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation.
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Basal epithelial stem cells are efficient targets for prostate cancer initiation.
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Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis.
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Bi-modal regulation of a formin by srGAP2.
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Biologic effects of platelet-derived growth factor receptor α blockade in uterine cancer.
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Bone Marrow Mesenchymal Stem Cell Transplantation Increases GAP-43 Expression via ERK1/2 and PI3K/Akt Pathways in Intracerebral Hemorrhage.
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Brain cancer stem cells display preferential sensitivity to Akt inhibition.
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C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway.
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CARHSP1 is required for effective tumor necrosis factor alpha mRNA stabilization and localizes to processing bodies and exosomes.
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CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation.
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Carbon monoxide differentially modulates STAT1 and STAT3 and inhibits apoptosis via a phosphatidylinositol 3-kinase/Akt and p38 kinase-dependent STAT3 pathway during anoxia-reoxygenation injury.
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Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy.
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Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling.
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Cardiometabolic Consequences of Targeted Anticancer Therapies.
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Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers.
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Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth.
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Cell signaling modifiers in prostate cancer.
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Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium.
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Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine.
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Changes in oligosaccharide chains of autoantibodies to GRP78 expressed during progression of malignant melanoma stimulate melanoma cell growth and survival.
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Characterization of PDK2 activity against protein kinase B gamma.
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Cholesterol feeding reduces vascular endothelial growth factor signaling in rabbit corporal tissues.
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Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy.
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Clinical Significance of PTEN Deletion, Mutation, and Loss of PTEN Expression in De Novo Diffuse Large B-Cell Lymphoma.
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Clinical implications of phosphorylated STAT3 expression in De Novo diffuse large B-cell lymphoma.
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Combined PI3K/Akt and Smad2 Activation Promotes Corneal Endothelial Cell Proliferation.
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Comprehensive molecular characterization of urothelial bladder carcinoma.
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Constitutive and inducible Akt activity promotes resistance to chemotherapy, trastuzumab, or tamoxifen in breast cancer cells.
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Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation.
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Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking.
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Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation.
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Deletion of the Imprinted Gene Grb10 Promotes Hematopoietic Stem Cell Self-Renewal and Regeneration.
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Deregulated PP1α phosphatase activity towards MAPK activation is antagonized by a tumor suppressive failsafe mechanism.
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Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii.
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Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women.
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Differential AMPK phosphorylation by glucagon and metformin regulates insulin signaling in human hepatic cells.
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Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation.
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Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology.
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Dissecting the roles of DR4, DR5 and c-FLIP in the regulation of geranylgeranyltransferase I inhibition-mediated augmentation of TRAIL-induced apoptosis.
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Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells.
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Dithiolethione compounds inhibit Akt signaling in human breast and lung cancer cells by increasing PP2A activity.
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Down-regulation of the erbB-2 receptor by trastuzumab (herceptin) enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast and ovarian cancer cell lines that overexpress erbB-2.
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Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model.
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Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes.
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Dysregulation of fatty acid synthesis and glycolysis in non-Hodgkin lymphoma.
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EGFR phosphorylation of DCBLD2 recruits TRAF6 and stimulates AKT-promoted tumorigenesis.
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EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts.
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ER stress modulates cellular metabolism.
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Early beneficial effects of bone marrow-derived mesenchymal stem cells overexpressing Akt on cardiac metabolism after myocardial infarction.
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Effect of short-term exercise training on insulin-stimulated PI 3-kinase activity in middle-aged men.
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Effects of spaceflight on murine skeletal muscle gene expression.
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Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis.
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Endosome and INPP4B.
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Endothelin-1 activates endothelial cell nitric-oxide synthase via heterotrimeric G-protein betagamma subunit signaling to protein jinase B/Akt.
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Epidermal growth factor receptor expression and signaling are essential in glutamine's cytoprotective mechanism in heat-stressed intestinal epithelial-6 cells.
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Epidermal growth factor receptor signaling pathway is frequently altered in ampullary carcinoma at protein and genetic levels.
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Erk/MAP kinase signaling pathway and neuroendocrine differentiation of non-small-cell lung cancer.
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Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart.
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Erythropoietin inhibits apoptosis in breast cancer cells via an Akt-dependent pathway without modulating in vivo chemosensitivity.
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Establishment of three-dimensional cultures of human pancreatic duct epithelial cells.
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Evaluating The Role Of Nitric Oxide Synthase In Oncogenic Ras-Driven Tumorigenesis.
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Evaluation of two phosphorylation sites improves the prognostic significance of Akt activation in non-small-cell lung cancer tumors.
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Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.
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Evidence supporting paracrine hypothesis for Akt-modified mesenchymal stem cell-mediated cardiac protection and functional improvement.
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Expression signatures of the lipid-based Akt inhibitors phosphatidylinositol ether lipid analogues in NSCLC cells.
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Extracellular Matrix Degradation Products Downregulate Neoplastic Esophageal Cell Phenotype.
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FOXO transcription factors control E2F1 transcriptional specificity and apoptotic function.
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FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms.
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Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation.
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Foxo-dependent Par-4 Upregulation Prevents Long-term Survival of Residual Cells Following PI3K-Akt Inhibition.
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Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression.
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Functional analysis of a mutant form of the receptor tyrosine kinase Tie2 causing venous malformations.
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Functional diversity of mammalian type 2C protein phosphatase isoforms: new tales from an old family.
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GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity.
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Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy.
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Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library.
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Genetic and pharmacologic identification of Akt as a mediator of brain-derived neurotrophic factor/TrkB rescue of neuroblastoma cells from chemotherapy-induced cell death.
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Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition.
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Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease.
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Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways.
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Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma.
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Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3.
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Handicapping the race to develop inhibitors of the phosphoinositide 3-kinase/Akt/mammalian target of rapamycin pathway.
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Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1.
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Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway.
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Hepatic FOXO1 Target Genes Are Co-regulated by Thyroid Hormone via RICTOR Protein Deacetylation and MTORC2-AKT Protein Inhibition.
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Hydrogen Sulfide Prevents and Partially Reverses Ozone-Induced Features of Lung Inflammation and Emphysema in Mice.
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IFN-α inhibits telomerase in human CD8⁺ T cells by both hTERT downregulation and induction of p38 MAPK signaling.
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IL-1 receptor signaling in podocytes limits susceptibility to glomerular damage.
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IQGAP1, a novel vascular endothelial growth factor receptor binding protein, is involved in reactive oxygen species--dependent endothelial migration and proliferation.
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Identification of a cell of origin for human prostate cancer.
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Identification of molecular subtypes of gastric cancer with different responses to PI3-kinase inhibitors and 5-fluorouracil.
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Identifying new small molecule anti-invasive compounds for glioma treatment.
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In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.
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In cardiomyocyte hypoxia, insulin-like growth factor-I-induced antiapoptotic signaling requires phosphatidylinositol-3-OH-kinase-dependent and mitogen-activated protein kinase-dependent activation of the transcription factor cAMP response element-binding protein.
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In vitro and in vivo molecular evidence of genistein action in augmenting the efficacy of cisplatin in pancreatic cancer.
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Inactivation of Icmt inhibits transformation by oncogenic K-Ras and B-Raf.
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Inactivation of the tumour suppressor, PTEN, in smooth muscle promotes a pro-inflammatory phenotype and enhances neointima formation.
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Increased lipid accumulation and insulin resistance in transgenic mice expressing DGAT2 in glycolytic (type II) muscle.
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Increased production of sonic hedgehog by ballooned hepatocytes.
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Induction of apoptosis in tumor-associated endothelial cells and therapy of orthotopic human pancreatic carcinoma in nude mice.
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Induction of preneoplastic lung lesions in guinea pigs by cigarette smoke inhalation and their exacerbation by high dietary levels of vitamins C and E.
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Inhibition of Pten deficient Castration Resistant Prostate Cancer by Targeting of the SET - PP2A Signaling axis.
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Inhibition of SRC expression and activity inhibits tumor progression and metastasis of human pancreatic adenocarcinoma cells in an orthotopic nude mouse model.
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Inhibition of mitogen-activated protein kinase and phosphatidylinositol 3-kinase activity in MCF-7 cells prevents estrogen-induced mitogenesis.
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Inhibition of p38 Mitogen-Activated Protein Kinase Enhances the Apoptosis Induced by Oxidized Low-Density Lipoprotein in Endothelial Progenitor Cells.
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Inhibition of the mammalian target of rapamycin (mTOR) in advanced pancreatic cancer: results of two phase II studies.
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Inhibition of the phosphatidylinositol 3-kinase/Akt/mammalian target of rapamycin pathway but not the MEK/ERK pathway attenuates laminin-mediated small cell lung cancer cellular survival and resistance to imatinib mesylate or chemotherapy.
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Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN.
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Initial testing (stage 1) of the Akt inhibitor GSK690693 by the pediatric preclinical testing program.
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Insulin receptor substrate is a mediator of phosphoinositide 3-kinase activation in quiescent pancreatic cancer cells.
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Interaction between TCL1 and Epac1 in the activation of Akt kinases in plasma membranes and nuclei of 8-CPT-2-O-Me-cAMP-stimulated macrophages.
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Is lithium neuroprotective? An updated mechanistic illustrated review.
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Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation.
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Klotho, an antiaging molecule, attenuates oxidant-induced alveolar epithelial cell mtDNA damage and apoptosis.
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LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
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LRRK2 and Rab10 coordinate macropinocytosis to mediate immunological responses in phagocytes.
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Leptin promotes the myofibroblastic phenotype in hepatic stellate cells by activating the hedgehog pathway.
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Ligation of cell surface GRP78 with antibody directed against the COOH-terminal domain of GRP78 suppresses Ras/MAPK and PI 3-kinase/AKT signaling while promoting caspase activation in human prostate cancer cells.
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Ligation of prostate cancer cell surface GRP78 activates a proproliferative and antiapoptotic feedback loop: a role for secreted prostate-specific antigen.
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Lipopolysaccharide stimulates mitochondrial biogenesis via activation of nuclear respiratory factor-1.
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Liver cancer: EphrinA2 promotes tumorigenicity through Rac1/Akt/NF-kappaB signaling pathway.
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Long-chain omega-3 fatty acids regulate bovine whole-body protein metabolism by promoting muscle insulin signalling to the Akt-mTOR-S6K1 pathway and insulin sensitivity.
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Loss of Nuclear Localized Parathyroid Hormone-Related Protein in Primary Breast Cancer Predicts Poor Clinical Outcome and Correlates with Suppressed Stat5 Signaling.
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Loss of phosphatase and tensin homologue increases transforming growth factor beta-mediated invasion with enhanced SMAD3 transcriptional activity.
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Loss of tumor suppressor IGFBP4 drives epigenetic reprogramming in hepatic carcinogenesis.
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Low-Dose Vertical Inhibition of the RAF-MEK-ERK Cascade Causes Apoptotic Death of KRAS Mutant Cancers.
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Lung inflammation, injury, and proliferative response after repetitive particulate hexavalent chromium exposure.
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Lung injury, inflammation and Akt signaling following inhalation of particulate hexavalent chromium.
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Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis.
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Lysophosphatidic acid promotes survival of androgen-insensitive prostate cancer PC3 cells via activation of NF-kappaB.
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Macrophage deficiency of p38alpha MAPK promotes apoptosis and plaque necrosis in advanced atherosclerotic lesions in mice.
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Maintenance of primary tumor phenotype and genotype in glioblastoma stem cells.
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Management of adverse events associated with idelalisib treatment: expert panel opinion.
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Manipulating JNK signaling with (--)-zuonin A.
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Mechanisms of erythropoietin-mediated cardioprotection during ischemia-reperfusion injury: role of protein kinase C and phosphatidylinositol 3-kinase signaling.
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Mesenchymal stem cells modified with Akt prevent remodeling and restore performance of infarcted hearts.
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Mesenchymal stem cells overexpressing Akt dramatically repair infarcted myocardium and improve cardiac function despite infrequent cellular fusion or differentiation.
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Metabolic regulation of Akt: roles reversed.
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Methed-up FOXOs can't in-Akt-ivate.
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Mitochondrial transcription factor A induction by redox activation of nuclear respiratory factor 1.
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Modulation of the unfolded protein response in prostate cancer cells by antibody-directed against the carboxyl-terminal domain of GRP78.
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Mosaic overgrowth with fibroadipose hyperplasia is caused by somatic activating mutations in PIK3CA.
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Mouse translation elongation factor eEF1A-2 interacts with Prdx-I to protect cells against apoptotic death induced by oxidative stress.
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Mst1/Mst2 regulate development and function of regulatory T cells through modulation of Foxo1/Foxo3 stability in autoimmune disease.
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Multiparity leads to obesity and inflammation in mothers and obesity in male offspring.
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Murine natural killer immunoreceptors use distinct proximal signaling complexes to direct cell function.
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Mutational analysis of the coding regions of the genes encoding protein kinase B-alpha and -beta, phosphoinositide-dependent protein kinase-1, phosphatase targeting to glycogen, protein phosphatase inhibitor-1, and glycogenin: lessons from a search for genetic variability of the insulin-stimulated glycogen synthesis pathway of skeletal muscle in NIDDM patients.
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Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia.
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Mycobacterium tuberculosis lipomannan blocks TNF biosynthesis by regulating macrophage MAPK-activated protein kinase 2 (MK2) and microRNA miR-125b.
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N-Myc Drives Neuroendocrine Prostate Cancer Initiated from Human Prostate Epithelial Cells.
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Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways.
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Nelfinavir, A lead HIV protease inhibitor, is a broad-spectrum, anticancer agent that induces endoplasmic reticulum stress, autophagy, and apoptosis in vitro and in vivo.
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Nelfinavir, a new anti-cancer drug with pleiotropic effects and many paths to autophagy.
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Neural plasticity and addiction: integrin-linked kinase and cocaine behavioral sensitization.
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Neurotrophin-3 signaling maintains maturational homeostasis between neuronal populations in the olfactory epithelium.
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Nordihydroguaiaretic acid inhibits insulin-like growth factor signaling, growth, and survival in human neuroblastoma cells.
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Notch promotes radioresistance of glioma stem cells.
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Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism.
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Novel PI analogues selectively block activation of the pro-survival serine/threonine kinase Akt.
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Oncogenic transformation by inhibitor-sensitive and -resistant EGFR mutants.
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Osteopontin is a proximal effector of leptin-mediated non-alcoholic steatohepatitis (NASH) fibrosis.
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Oxidant-mediated Akt activation in human RPE cells.
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Oxidized low density lipoprotein impairs endothelial progenitor cells by regulation of endothelial nitric oxide synthase.
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Oxidized low-density lipoprotein induces apoptosis in endothelial progenitor cells by inactivating the phosphoinositide 3-kinase/Akt pathway.
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P2RY2-AKT activation is a therapeutically actionable consequence of XPO1 inhibition in acute myeloid leukemia.
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P38MAP kinase, but not phosphoinositol-3 kinase, signal downstream of glutamine-mediated fibronectin-integrin signaling after intestinal injury.
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PI3K/Akt and apoptosis: size matters.
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PIP5K1α promotes myogenic differentiation via AKT activation and calcium release.
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PTEN Expression as a Predictor of Response to Focal Adhesion Kinase Inhibition in Uterine Cancer.
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PTEN hamartoma tumor syndromes.
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PTEN reconstitution alters glioma responses to c-Met pathway inhibition.
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Parabacteroides distasonis attenuates toll-like receptor 4 signaling and Akt activation and blocks colon tumor formation in high-fat diet-fed azoxymethane-treated mice.
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Paracrine action accounts for marked protection of ischemic heart by Akt-modified mesenchymal stem cells.
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Perfluorobutane sulfonate exposure disrupted human placental cytotrophoblast cell proliferation and invasion involving in dysregulating preeclampsia related genes.
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Perifosine treatment in chronic lymphocytic leukemia: results of a phase II clinical trial and in vitro studies.
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Perifosine: update on a novel Akt inhibitor.
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Periostin potently promotes metastatic growth of colon cancer by augmenting cell survival via the Akt/PKB pathway.
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Pharmacological modulation of the AKT/microRNA-199a-5p/CAV1 pathway ameliorates cystic fibrosis lung hyper-inflammation.
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Phase 1 clinical trial of HER2-specific immunotherapy with concomitant HER2 kinase inhibition [corrected].
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Phase I study and biomarker analysis of lapatinib and concurrent radiation for locally advanced breast cancer.
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Phase II study of the farnesyltransferase inhibitor R115777 in advanced melanoma (CALGB 500104).
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Phosphatidylinositol 3-kinase activates ERK in primary sensory neurons and mediates inflammatory heat hyperalgesia through TRPV1 sensitization.
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Phosphatidylinositol 3-kinase pathway activation in breast cancer brain metastases.
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Phosphatidylinositol 3-kinase-AKT-mammalian target of rapamycin pathway is essential for neuroendocrine differentiation of prostate cancer.
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Phosphatidylinositol ether lipid analogues that inhibit AKT also independently activate the stress kinase, p38alpha, through MKK3/6-independent and -dependent mechanisms.
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Phospholipase D in TCR-Mediated Signaling and T Cell Activation.
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Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1.
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Phosphorylation of Src by phosphoinositide 3-kinase regulates beta-adrenergic receptor-mediated EGFR transactivation.
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Phosphorylation of Threonine 794 on Tie1 by Rac1/PAK1 Reveals a Novel Angiogenesis Regulatory Pathway.
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Polyclonal HER2-specific antibodies induced by vaccination mediate receptor internalization and degradation in tumor cells.
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Polycythemia vera erythroid precursors exhibit increased proliferation and apoptosis resistance associated with abnormal RAS and PI3K pathway activation.
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Polymorphisms in the AKT1 and AKT2 genes and oesophageal squamous cell carcinoma risk in an Eastern Chinese population.
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Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)-mediated signaling pathway.
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Potentiation of the effect of erlotinib by genistein in pancreatic cancer: the role of Akt and nuclear factor-kappaB.
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Precision Medicine Approaches When Prostate Cancer Akts Up.
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Preferential inhibition of Akt and killing of Akt-dependent cancer cells by rationally designed phosphatidylinositol ether lipid analogues.
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Pressure overload induces greater hypertrophy and mortality in female mice with p38alpha MAPK inhibition.
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Primary cilia and the reciprocal activation of AKT and SMAD2/3 regulate stretch-induced autophagy in trabecular meshwork cells.
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Pro- and antiapoptotic proteins regulate apoptosis but do not protect against cytokine-mediated cytotoxicity in rat islets and beta-cell lines.
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Probiotic administration reduces mortality and improves intestinal epithelial homeostasis in experimental sepsis.
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Profiling Hsp90 differential expression and the molecular effects of the Hsp90 inhibitor IPI-504 in high-grade glioma models.
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Prognostic significance of clinical factors and Akt activation in patients with bronchioloalveolar carcinoma.
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Progranulin haploinsufficiency causes biphasic social dominance abnormalities in the tube test.
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Prostate apoptosis response protein 4 sensitizes human colon cancer cells to chemotherapeutic 5-FU through mediation of an NF kappaB and microRNA network.
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Prostate epithelial cell of origin determines cancer differentiation state in an organoid transformation assay.
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Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.
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Protection against oxidized low-density lipoprotein-induced vascular endothelial cell death by integrin-linked kinase.
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Protein kinase B controls transcriptional programs that direct cytotoxic T cell fate but is dispensable for T cell metabolism.
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Proteomic analysis of radiation-induced changes in rat lung: Modulation by the superoxide dismutase mimetic MnTE-2-PyP(5+).
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Pten-null tumors cohabiting the same lung display differential AKT activation and sensitivity to dietary restriction.
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RAS signaling promotes resistance to JAK inhibitors by suppressing BAD-mediated apoptosis.
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Rapamycin and p53 act on different pathways to induce G1 arrest in mammalian cells.
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Rapid Akt activation by nicotine and a tobacco carcinogen modulates the phenotype of normal human airway epithelial cells.
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Re: Akt phosphorylation and gefitinib efficacy in patients with advanced non-small-cell lung cancer.
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Receptor-recognized α₂-macroglobulin binds to cell surface-associated GRP78 and activates mTORC1 and mTORC2 signaling in prostate cancer cells.
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Regulation of B-cell development by BCAP and CD19 through their binding to phosphoinositide 3-kinase.
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Regulation of mast cell survival and function by tuberous sclerosis complex 1.
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Requirement of dendritic Akt degradation by the ubiquitin-proteasome system for neuronal polarity.
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Rescue of Pressure Overload-Induced Heart Failure by Estrogen Therapy.
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Resistance to tyrosine kinase inhibition by mutant epidermal growth factor receptor variant III contributes to the neoplastic phenotype of glioblastoma multiforme.
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Revival of the abandoned therapeutic wortmannin by nanoparticle drug delivery.
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Role of YAP1 as a Marker of Sensitivity to Dual AKT and P70S6K Inhibition in Ovarian and Uterine Malignancies.
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Role of autonomous androgen receptor signaling in prostate cancer initiation is dichotomous and depends on the oncogenic signal.
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Role of insulin-like growth factor-binding protein 5 (IGFBP5) in organismal and pancreatic beta-cell growth.
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Roles of genetic variants in the PI3K and RAS/RAF pathways in susceptibility to endometrial cancer and clinical outcomes.
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SENP3-mediated host defense response contains HBV replication and restores protein synthesis.
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SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells.
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SHP-1 as a critical regulator of Mycoplasma pneumoniae-induced inflammation in human asthmatic airway epithelial cells.
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STIM1-Ca(2+) signaling is required for the hypertrophic growth of skeletal muscle in mice.
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Second messenger systems in human gliomas.
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Secreted frizzled related protein 2 (Sfrp2) is the key Akt-mesenchymal stem cell-released paracrine factor mediating myocardial survival and repair.
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Secreted nuclear protein DEK regulates hematopoiesis through CXCR2 signaling.
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Secreted protein acidic, rich in cysteine (SPARC), mediates cellular survival of gliomas through AKT activation.
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Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background.
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Single Cell Chemical Cytometry of Akt Activity in Rheumatoid Arthritis and Normal Fibroblast-like Synoviocytes in Response to Tumor Necrosis Factor α.
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Smooth Muscle Cell-targeted RNA Aptamer Inhibits Neointimal Formation.
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Somatic variants in diverse genes leads to a spectrum of focal cortical malformations.
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Spectrum of activity and molecular correlates of response to phosphatidylinositol ether lipid analogues, novel lipid-based inhibitors of Akt.
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Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells.
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Stiff stroma increases breast cancer risk by inducing the oncogene ZNF217.
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Strain-specific spontaneous and NNK-mediated tumorigenesis in Pten+/- mice.
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Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia.
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Synephrine Hydrochloride Suppresses Esophageal Cancer Tumor Growth and Metastatic Potential through Inhibition of Galectin-3-AKT/ERK Signaling.
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Synthetic lethality by targeting EZH2 methyltransferase activity in ARID1A-mutated cancers.
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TASK-1 and TASK-3 channels modulate pressure overload-induced cardiac remodeling and dysfunction.
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TD-19, an erlotinib derivative, induces epidermal growth factor receptor wild-type nonsmall-cell lung cancer apoptosis through CIP2A-mediated pathway.
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TGF-beta: a new role for an old AktTOR.
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TRPC1 channels are critical for hypertrophic signaling in the heart.
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TSC1 Promotes B Cell Maturation but Is Dispensable for Germinal Center Formation.
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Tamoxifen and tamoxifen ethyl bromide induce apoptosis in acutely damaged mammary epithelial cells through modulation of AKT activity.
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Targeting Akt in cancer therapy.
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Targeting Akt3 signaling in malignant melanoma using isoselenocyanates.
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Targeting N-cadherin increases vascular permeability and differentially activates AKT in melanoma.
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Targeting SET/I(2)PP2A oncoprotein functions as a multi-pathway strategy for cancer therapy.
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Targeting the PI3K/Akt/mTOR pathway in castration-resistant prostate cancer.
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Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations.
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Testing of the Akt/PKB inhibitor MK-2206 by the Pediatric Preclinical Testing Program.
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Testosterone regulation of Akt/mTORC1/FoxO3a signaling in skeletal muscle.
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The Akt signaling pathway: an emerging therapeutic target in malignant melanoma.
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The Bone Marrow Protects and Optimizes Immunological Memory during Dietary Restriction.
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The CD28 signaling pathway regulates glucose metabolism.
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The CO/HO system reverses inhibition of mitochondrial biogenesis and prevents murine doxorubicin cardiomyopathy.
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The Caspase-3/PKCδ/Akt/VEGF-A Signaling Pathway Mediates Tumor Repopulation during Radiotherapy.
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The HIV-1 protease inhibitor nelfinavir activates PP2 and inhibits MAPK signaling in macrophages: a pathway to reduce inflammation.
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The Human FSGS-Causing ANLN R431C Mutation Induces Dysregulated PI3K/AKT/mTOR/Rac1 Signaling in Podocytes.
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The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity.
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The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to hyperactivate AKT and confer resistance to AKT inhibitors.
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The PI 3-kinase/Akt signaling pathway is activated due to aberrant Pten expression and targets transcription factors NF-kappaB and c-Myc in pancreatic cancer cells.
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The activity of letrozole in patients with advanced or recurrent endometrial cancer and correlation with biological markers--a study of the National Cancer Institute of Canada Clinical Trials Group.
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The cAMP-activated GTP exchange factor, Epac1 upregulates plasma membrane and nuclear Akt kinase activities in 8-CPT-2-O-Me-cAMP-stimulated macrophages: Gene silencing of the cAMP-activated GTP exchange Epac1 prevents 8-CPT-2-O-Me-cAMP activation of Akt activity in macrophages.
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The chemopreventive agent myoinositol inhibits Akt and extracellular signal-regulated kinase in bronchial lesions from heavy smokers.
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The cytoplasmic deacetylase HDAC6 is required for efficient oncogenic tumorigenesis.
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The development of phosphatidylinositol ether lipid analogues as inhibitors of the serine/threonine kinase, Akt.
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The effects of varying dietary carbohydrate and fat content on survival in a murine LNCaP prostate cancer xenograft model.
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The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis.
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The hormone receptor GUCY2C suppresses intestinal tumor formation by inhibiting AKT signaling.
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The immunity-related GTPase Irgm3 relieves endoplasmic reticulum stress response during coxsackievirus B3 infection via a PI3K/Akt dependent pathway.
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The impact of activated p-AKT expression on clinical outcomes in diffuse large B-cell lymphoma: a clinicopathological study of 262 cases.
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The pleiotropic effects of prebiotic galacto-oligosaccharides on the aging gut.
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The proximity-labeling technique BioID identifies sorting nexin 6 as a member of the insulin-like growth factor 1 (IGF1)-IGF1 receptor pathway.
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The role of the Akt/mTOR pathway in tobacco carcinogen-induced lung tumorigenesis.
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Thrombin-cleaved COOH(-) terminal osteopontin peptide binds with cyclophilin C to CD147 in murine breast cancer cells.
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Tissue transglutaminase regulates focal adhesion kinase/AKT activation by modulating PTEN expression in pancreatic cancer cells.
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Tobacco carcinogen-induced cellular transformation increases Akt activation in vitro and in vivo.
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Tobacco carcinogen-induced cellular transformation increases activation of the phosphatidylinositol 3'-kinase/Akt pathway in vitro and in vivo.
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Tobacco components stimulate Akt-dependent proliferation and NFkappaB-dependent survival in lung cancer cells.
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Tocopherol-associated protein suppresses prostate cancer cell growth by inhibition of the phosphoinositide 3-kinase pathway.
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Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli.
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Transcriptional regulation of Bim by FOXO3a and Akt mediates scleroderma serum-induced apoptosis in endothelial progenitor cells.
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Tumour maintenance is mediated by eNOS.
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Twenty-year survival in glioblastoma: a case report and molecular profile.
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Two insulin receptors determine alternative wing morphs in planthoppers.
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Tyrosine 1101 of Tie2 is the major site of association of p85 and is required for activation of phosphatidylinositol 3-kinase and Akt.
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Ulcerative keratitis in gastrointestinal stromal tumor patients treated with perifosine.
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Upregulated claudin-1 expression promotes colitis-associated cancer by promoting β-catenin phosphorylation and activation in Notch/p-AKT-dependent manner.
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Upregulation of AKT1 protein expression in forskolin-stimulated macrophage: evidence from ChIP analysis that CREB binds to and activates the AKT1 promoter.
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Upregulation of mTORC2 activation by the selective agonist of EPAC, 8-CPT-2Me-cAMP, in prostate cancer cells: assembly of a multiprotein signaling complex.
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Urinary bladder organ hypertrophy is partially regulated by Akt1-mediated protein synthesis pathway.
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Urolithin A attenuates severity of chronic pancreatitis associated with continued alcohol intake by inhibiting PI3K/AKT/mTOR signaling.
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VEGF induces Tie2 shedding via a phosphoinositide 3-kinase/Akt dependent pathway to modulate Tie2 signaling.
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WNK1 regulates uterine homeostasis and its ability to support pregnancy.
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miR-21 improves the neurological outcome after traumatic brain injury in rats.
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microRNA-21-5p dysregulation in exosomes derived from heart failure patients impairs regenerative potential.
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{beta}-Arrestin-2 Mediates Anti-apoptotic Signaling through Regulation of BAD Phosphorylation.
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Keywords of People
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Ciofani, Maria,
Associate Professor of Immunology,
Cell Biology
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Sampson, John Howard,
Robert H., M.D. and Gloria Wilkins Professor of Neurosurgery, in the School of Medicine,
Biomedical Engineering
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Zhong, Xiaoping,
Professor of Pediatrics,
Immunology