Proto-Oncogene Proteins c-fyn

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  Subject Areas on Research

  • A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. 
  • Brain migration disorder and T-cell activation deficiency associated with abnormal signaling through TCR/CD3 complex and hyperactivity of Fyn tyrosine kinase. 
  • Differential requirement for the SAP-Fyn interaction during NK T cell development and function. 
  • HIV infection--induced posttranslational modification of T cell signaling molecules associated with disease progression. 
  • Ischemic injury to kidney induces glomerular podocyte effacement and dissociation of slit diaphragm proteins Neph1 and ZO-1. 
  • Lyn but not Fyn kinase controls IgG-mediated systemic anaphylaxis. 
  • Multiple constraints at the level of TCRalpha rearrangement impact Valpha14i NKT cell development. 
  • Neural cell adhesion molecule-mediated Fyn activation promotes GABAergic synapse maturation in postnatal mouse cortex. 
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  Keywords of People

  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Immunology