Toll-Like Receptors

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  Subject Areas on Research

  • Activated B cells modified by electroporation of multiple mRNAs encoding immune stimulatory molecules are comparable to mature dendritic cells in inducing in vitro antigen-specific T-cell responses. 
  • Altered toll-like receptor responsiveness underlies a dominant heritable defect in B cell tolerance in autoimmune New Zealand Black mice. 
  • Ambient ozone and pulmonary innate immunity. 
  • An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. 
  • Antibodies to DNA: infection or genetics? 
  • Apoptosis and NF-kappa B: the FADD connection. 
  • BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance. 
  • Bisphosphonates target B cells to enhance humoral immune responses. 
  • CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. 
  • Characterization of the interleukin 1 receptor-associated kinase 4 (IRAK4)-encoding gene in salmonid fish: the functional copy is rearranged in Oncorhynchus mykiss and that factor can impair TLR signaling in mammalian cells. 
  • Cotransfection of DC with TLR4 and MART-1 RNA induces MART-1-specific responses. 
  • Cryptosporidium-malnutrition interactions: mucosal disruption, cytokines, and TLR signaling in a weaned murine model. 
  • DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonists. 
  • Damage-Associated Molecular Patterns Induce Inflammatory Injury During Machine Preservation of the Liver: Potential Targets to Enhance a Promising Technology. 
  • Dendritic cells stimulated with Actinobacillus actinomycetemcomitans elicit rapid gamma interferon responses by natural killer cells. 
  • Development of a Grp94 inhibitor. 
  • Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii. 
  • Diacylglycerol kinases in immune cell function and self-tolerance. 
  • Dietary omega-3 fatty acid intake impacts peripheral blood DNA methylation -anti-inflammatory effects and individual variability in a pilot study. 
  • Different adjuvanted pediatric HIV envelope vaccines induced distinct plasma antibody responses despite similar B cell receptor repertoires in infant rhesus macaques. 
  • Differential expression of intracellular and secreted osteopontin isoforms by murine macrophages in response to toll-like receptor agonists. 
  • Differential role for TLR3 in respiratory syncytial virus-induced chemokine expression. 
  • EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. 
  • Effects of cartilage impact with and without fracture on chondrocyte viability and the release of inflammatory markers. 
  • Emerging role of Toll-like receptors in the control of pain and itch. 
  • Expression levels of TLRs involved in viral recognition in PBMCs from HIV-1-infected patients failing antiretroviral therapy. 
  • Expression of Toll-like receptors in human endometrial epithelial cells and cell lines. 
  • Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. 
  • Genes of innate immunity and the biological response to inhaled ozone. 
  • Genetic variant of IRAK2 in the toll-like receptor signaling pathway and survival of non-small cell lung cancer. 
  • Glial and Neuroimmune Mechanisms as Critical Modulators of Drug Use and Abuse. 
  • HIV-1 activates macrophages independent of Toll-like receptors. 
  • HIV-1 infection-induced apoptotic microparticles inhibit human DCs via CD44. 
  • HMGB1 and microparticles as mediators of the immune response to cell death. 
  • Holding the Inflammatory System in Check: TLRs and NLRs. 
  • How Do Sensory Neurons Sense Danger Signals? 
  • ICON: the early diagnosis of congenital immunodeficiencies. 
  • Identification of novel innate immune genes by transcriptional profiling of macrophages stimulated with TLR ligands. 
  • Identification of recombinant antibodies against multiple distinct toll-like receptors by homolog mining a single immune scFv phage library. 
  • Immune pathogenesis of heparin-induced thrombocytopenia. 
  • Immunologic Effects of Stereotactic Body Radiotherapy in Dogs with Spontaneous Tumors and the Impact of Intratumoral OX40/TLR Agonist Immunotherapy. 
  • Immunoregulation on the ocular surface: 2nd Cullen Symposium. 
  • Immunotherapy of malignant brain tumors. 
  • Improving defences at the portal of HIV entry: mucosal and innate immunity. 
  • In vivo expansion, persistence, and function of peptide vaccine-induced CD8 T cells occur independently of CD4 T cells. 
  • Increased expression of Toll-like receptors 2, 3, 4 and 7 mRNA in the kidney and intestine of a septic mouse model. 
  • Induction of human dendritic cell maturation using transfection with RNA encoding a dominant positive toll-like receptor 4. 
  • Inflammasomes are important mediators of cyclophosphamide-induced bladder inflammation. 
  • Inhibition of Methicillin-resistant Staphylococcus aureus-induced cytokines mRNA production in human bone marrow derived mesenchymal stem cells by 1,25-dihydroxyvitamin D3. 
  • Innate and adaptive immunity cooperate flexibly to maintain host-microbiota mutualism. 
  • Innate immunity and antimicrobial defense systems in psoriasis. 
  • Innate immunity influences long-term outcomes after human lung transplant. 
  • Interferon beta inhibits the Th17 cell-mediated autoimmune response in patients with relapsing-remitting multiple sclerosis. 
  • Intracellular communication and immunothrombosis in sepsis. 
  • Intracellular osteopontin (iOPN) and immunity. 
  • Itch control by Toll-like receptors. 
  • Lactobacillus rhamnosus GG and Bifidobacterium longum attenuate lung injury and inflammatory response in experimental sepsis. 
  • Ligand-independent toll-like receptor signals generated by ectopic overexpression of MyD88 generate local and systemic antitumor immunity. 
  • Lymphangitis after self-administration of lipopolysaccharide. 
  • Microparticles as a source of extracellular DNA. 
  • Microparticles as autoadjuvants in the pathogenesis of SLE. 
  • Molecular control of steady-state dendritic cell maturation and immune homeostasis. 
  • Multiple Nod-like receptors activate caspase 1 during Listeria monocytogenes infection. 
  • Mycobacteria manipulate macrophage recruitment through coordinated use of membrane lipids. 
  • New insights into the mechanisms of itch: are pain and itch controlled by distinct mechanisms? 
  • Nucleic acid-binding polymers as anti-inflammatory agents. 
  • Outside influence: TLRs direct hematopoietic cell fates. 
  • PAMPs and DAMPs: signal 0s that spur autophagy and immunity. 
  • Pain regulation by non-neuronal cells and inflammation. 
  • Paired Toll-like receptor agonists enhance vaccine therapy through induction of interleukin-12. 
  • Phase I study utilizing a novel antigen-presenting cell-targeted vaccine with Toll-like receptor stimulation to induce immunity to self-antigens in cancer patients. 
  • Phylogeny of Toll-like receptor signaling: adapting the innate response. 
  • Probiotic administration reduces mortality and improves intestinal epithelial homeostasis in experimental sepsis. 
  • Progesterone Improves Neurobehavioral Outcome in Models of Intracerebral Hemorrhage. 
  • Programming human dendritic cells with mRNA. 
  • Programming the magnitude and persistence of antibody responses with innate immunity. 
  • Receptor signaling in immune cell development and function. 
  • Regulatory B cell production of IL-10 inhibits lymphoma depletion during CD20 immunotherapy in mice. 
  • Rhbdd3 controls autoimmunity by suppressing the production of IL-6 by dendritic cells via K27-linked ubiquitination of the regulator NEMO. 
  • Role of Toll-like receptor-driven innate immunity in thoracic organ transplantation. 
  • Role of Toll-like receptors in HMGB1 release from macrophages. 
  • Sensing the enemy, containing the threat: cell-autonomous immunity to Chlamydia trachomatis. 
  • Sex-Specific Effects of Progesterone on Early Outcome of Intracerebral Hemorrhage. 
  • Staphylococcus aureus secretes immunomodulatory RNA and DNA via membrane vesicles. 
  • Stressed-Out T Cells Fragment the Mind. 
  • Stromal cell independent B cell development in vitro: generation and recovery of autoreactive clones. 
  • T-independent activation-induced cytidine deaminase expression, class-switch recombination, and antibody production by immature/transitional 1 B cells. 
  • TLR agonists regulate PDGF-B production and cell proliferation through TGF-beta/type I IFN crosstalk. 
  • TLR-mediated immune responses in the urinary tract. 
  • Targeting High Mobility Group Box-1 (HMGB1) Promotes Cell Death in Myelodysplastic Syndrome. 
  • The Cutaneous Wound Innate Immunological Microenvironment. 
  • The First B-Cell Tolerance Checkpoint in Mice and Humans: Control by AID. 
  • The Immunology of Syncytialized Trophoblast. 
  • The development and function of regulatory B cells expressing IL-10 (B10 cells) requires antigen receptor diversity and TLR signals. 
  • The effect of toll-like receptors and toll-like receptor genetics in human disease. 
  • The immunologic constant of rejection. 
  • The innate immune sensor NLRC3 attenuates Toll-like receptor signaling via modification of the signaling adaptor TRAF6 and transcription factor NF-κB. 
  • The nucleic acid scavenger polyamidoamine third-generation dendrimer inhibits fibroblast activation and granulation tissue contraction. 
  • The relationship between apoptosis and high-mobility group protein 1 release from murine macrophages stimulated with lipopolysaccharide or polyinosinic-polycytidylic acid. 
  • The release of microparticles by RAW 264.7 macrophage cells stimulated with TLR ligands. 
  • The role of Toll-like receptor 4 in environmental airway injury in mice. 
  • The role of innate immunity in acute allograft rejection after lung transplantation. 
  • The role of innate immunity in the induction of autoimmunity. 
  • Toll-Like Receptors -2, -3, -4 and -7 Expression Patterns in the Liver of a CLP-Induced Sepsis Mouse Model. 
  • Toll-like receptor 4 (TLR4)-deficient murine macrophage cell line as an in vitro assay system to show TLR4-independent signaling of Bacteroides fragilis lipopolysaccharide. 
  • Toll-like receptor activation as a biomarker in traumatically injured patients. 
  • Toll-like receptor agonists as third signals for dendritic cell-tumor fusion vaccines. 
  • Toll-like receptor signaling: common pathways that drive cardiovascular disease and rheumatoid arthritis. 
  • Toll-like receptors and allograft rejection. 
  • Toll-like receptors in the pathogenesis of human disease. 
  • Toll-like receptors, innate immunity and lung transplantation. 
  • Toll-like receptors, their ligands, and atherosclerosis. 
  • Transcriptional control of mitochondrial biogenesis and its interface with inflammatory processes. 
  • Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli. 
  • U1 RNA induces innate immunity signaling. 
  • Unc93b Induces Apoptotic Cell Death and Is Cleaved by Host and Enteroviral Proteases. 
  • When is an adjuvant not an adjuvant? Overview. 
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  Keywords of People

  • Lee, Walter T, Professor of Head and Neck Surgery & Communication Sciences, Radiation Oncology
  • Muir, Kelly Walton, Associate Professor of Ophthalmology, Ophthalmology, Glaucoma
  • Shinohara, Mari L., Professor of Integrative Immunobiology, Cell Biology
  • Zhong, Xiaoping, Professor of Pediatrics, Integrative Immunobiology