NF-E2-Related Factor 2
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Subject Areas on Research
- A new BEACON of hope for the treatment of inflammation? The endogenous metabolite itaconate as an alternative activator of the KEAP1-Nrf2 system.
- Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation.
- Activation of Nrf2 Pathway Contributes to Neuroprotection by the Dietary Flavonoid Tiliroside.
- Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis.
- Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer.
- Acute kidney injury to chronic kidney disease transition: insufficient cellular stress response.
- Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms.
- Antioxidant responses and NRF2 in synergistic developmental toxicity of PAHs in zebrafish.
- Arctigenin Attenuates Ischemia/Reperfusion Induced Ventricular Arrhythmias by Decreasing Oxidative Stress in Rats.
- Biology of p62/sequestosome-1 in Age-Related Macular Degeneration (AMD).
- CDDO-Me, Sulforaphane and tBHQ attenuate the RANKL-induced osteoclast differentiation via activating the NRF2-mediated antioxidant response.
- Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus.
- Embryonic exposure to Mono(2-ethylhexyl) phthalate (MEHP) disrupts pancreatic organogenesis in zebrafish (Danio rerio).
- Glycosylation of KEAP1 links nutrient sensing to redox stress signaling.
- Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1.
- Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal.
- Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2.
- Identification of driver genes in hepatocellular carcinoma by exome sequencing.
- Induction of the protective antioxidant response element pathway by 6-hydroxydopamine in vivo and in vitro.
- Inherited variants in mitochondrial biogenesis genes may influence epithelial ovarian cancer risk.
- Inhibition of neuroinflammation by thymoquinone requires activation of Nrf2/ARE signalling.
- Inhibition of neuroinflammation in BV2 microglia by the biflavonoid kolaviron is dependent on the Nrf2/ARE antioxidant protective mechanism.
- KEAP1-modifying small molecule reveals muted NRF2 signaling responses in neural stem cells from Huntington's disease patients.
- Keap1 modification and nuclear accumulation in response to S-nitrosocysteine.
- LKB1 Loss induces characteristic patterns of gene expression in human tumors associated with NRF2 activation and attenuation of PI3K-AKT.
- Nitric oxide stimulates Nrf2 nuclear translocation in vascular endothelium.
- Nrf2 activation: a potential strategy for the prevention of acute mountain sickness.
- Nrf2 deficiency in myeloid cells is not sufficient to protect mice from high-fat diet-induced adipose tissue inflammation and insulin resistance.
- Nrf2 inactivation enhances placental angiogenesis in a preeclampsia mouse model and improves maternal and fetal outcomes.
- Nrf2 is the key to chemotherapy resistance in MCF7 breast cancer cells under hypoxia.
- Nrf2 promotes alveolar mitochondrial biogenesis and resolution of lung injury in Staphylococcus aureus pneumonia in mice.
- Nrf2 signaling modulates cigarette smoke-induced complement activation in retinal pigmented epithelial cells.
- Nrf2, a multi-organ protector?
- Nuclear factor erythroid-derived factor 2-related factor 2 regulates transcription of CCAAT/enhancer-binding protein β during adipogenesis.
- Pan-cancer transcriptomic analysis associates long non-coding RNAs with key mutational driver events.
- Peroxisome proliferator-activated receptor γ co-activator 1-α as a critical co-activator of the murine hepatic oxidative stress response and mitochondrial biogenesis in Staphylococcus aureus sepsis.
- Phase 1 Study of a Sulforaphane-Containing Broccoli Sprout Homogenate for Sickle Cell Disease.
- Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription.
- Proteomic characterization of the cellular response to nitrosative stress mediated by s-nitrosoglutathione reductase inhibition.
- ROS signaling, oxidative stress and Nrf2 in pancreatic beta-cell function.
- Refining the role of BRCA1 in combating oxidative stress.
- S-nitrosothiol signaling regulates liver development and improves outcome following toxic liver injury.
- SIRT2- and NRF2-Targeting Thiazole-Containing Compound with Therapeutic Activity in Huntington's Disease Models.
- Sequestration of mitochondrial iron by silica particle initiates a biological effect.
- Targeting ABL1-mediated oxidative stress adaptation in fumarate hydratase-deficient cancer.
- The Nrf2-ARE pathway: an indicator and modulator of oxidative stress in neurodegeneration.
- Three novel genetic variants in NRF2 signaling pathway genes are associated with pancreatic cancer risk.
- Transcription factor Nrf2 hyperactivation in early-phase renal ischemia-reperfusion injury prevents tubular damage progression.
- Transcriptional control of glyoxalase 1 by Nrf2 provides a stress-responsive defence against dicarbonyl glycation.
- microRNA miR-144 modulates oxidative stress tolerance and associates with anemia severity in sickle cell disease.