Glucose Transporter Type 1

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  Subject Areas on Research

  • Acetazolamide-responsive Episodic Ataxia Without Baseline Deficits or Seizures Secondary to GLUT1 Deficiency: A Case Report and Review of the Literature. 
  • Acidic stress promotes a glioma stem cell phenotype. 
  • Akt and Bcl-xL promote growth factor-independent survival through distinct effects on mitochondrial physiology. 
  • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. 
  • An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. 
  • Chronic growth hormone treatment in normal rats reduces post-prandial skeletal muscle plasma membrane GLUT1 content, but not glucose transport or GLUT4 expression and localization. 
  • Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth. 
  • Correlation of FDG-PET imaging with Glut-1 and Glut-3 expression in early-stage non-small cell lung cancer. 
  • Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. 
  • Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. 
  • Differential glucose requirement in skin homeostasis and injury identifies a therapeutic target for psoriasis. 
  • ER stress modulates cellular metabolism. 
  • Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes. 
  • Effect of reduced inspired oxygen on fetal growth and maternal glucose metabolism in rat pregnancy. 
  • Efferocytosis induces a novel SLC program to promote glucose uptake and lactate release. 
  • Evidence for brain glucose dysregulation in Alzheimer's disease. 
  • Extracellular Matrix Remodeling Regulates Glucose Metabolism through TXNIP Destabilization. 
  • Facilitative glucose transporter Glut1 is actively excluded from rod outer segments. 
  • Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. 
  • GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy. 
  • Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter. 
  • Glucose metabolism as a target of histone deacetylase inhibitors. 
  • Glucose metabolism in lymphocytes is a regulated process with significant effects on immune cell function and survival. 
  • Glucose transporter 1-mediated glucose uptake is limiting for B-cell acute lymphoblastic leukemia anabolic metabolism and resistance to apoptosis. 
  • Hel-N1, an RNA-binding protein, is a ligand for an A + U rich region of the GLUT1 3' UTR. 
  • Hepatocyte nuclear factor-1β (HNF-1β) promotes glucose uptake and glycolytic activity in ovarian clear cell carcinoma. 
  • IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival. 
  • Immunohistochemical characterization of Renaut bodies in superficial digital nerves: further evidence supporting their perineurial cell origin. 
  • Impaired enolase 1 glycolytic activity restrains effector functions of tumor-infiltrating CD8+ T cells. 
  • In the absence of extrinsic signals, nutrient utilization by lymphocytes is insufficient to maintain either cell size or viability. 
  • Isoform-specific requirement for Akt1 in the developmental regulation of cellular metabolism during lactation. 
  • Leptin metabolically licenses T cells for activation to link nutrition and immunity. 
  • Localization and quantification of glucose transporters in liver of growth-retarded fetal and neonatal rats. 
  • Mechanisms and methods in glucose metabolism and cell death. 
  • Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells. 
  • Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype. 
  • Myeloid Slc2a1-Deficient Murine Model Revealed Macrophage Activation and Metabolic Phenotype Are Fueled by GLUT1. 
  • No evidence for maternal-fetal microchimerism in infantile hemangioma: a molecular genetic investigation. 
  • PKCs Sweeten Cell Metabolism by Phosphorylation of Glut1. 
  • Regulation of cerebral glucose metabolism. 
  • Retinal neovascular markers in retinopathy of prematurity: aetiological implications. 
  • SGK1 signaling promotes glucose metabolism and survival in extracellular matrix detached cells. 
  • STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. 
  • Structural domains that contribute to substrate specificity in facilitated glucose transporters are distinct from those involved in kinetic function: studies with GLUT-1/GLUT-2 chimeras. 
  • Suppression of Glut1 and Glucose Metabolism by Decreased Akt/mTORC1 Signaling Drives T Cell Impairment in B Cell Leukemia. 
  • Targeting GLUT1 and the Warburg effect in renal cell carcinoma by chemical synthetic lethality. 
  • Targeting Glycolysis in Alloreactive T Cells to Prevent Acute Graft-Versus-Host Disease While Preserving Graft-Versus-Leukemia Effect. 
  • Targeting In Vivo Metabolic Vulnerabilities of Th2 and Th17 Cells Reduces Airway Inflammation. 
  • The CD28 signaling pathway regulates glucose metabolism. 
  • The glucose transporter Glut1 is selectively essential for CD4 T cell activation and effector function. 
  • Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism. 
  • Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH. 
  • YAP: The nexus between metabolism and cardiac remodeling. 
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  Keywords of People

  • McDonnell, Donald Patrick, Glaxo-Wellcome Distinguished Professor of Molecular Cancer Biology, in the School of Medicine, Cell Biology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Patz Jr., Edward F., James and Alice Chen Distinguished Professor of Radiology, Pathology