Glucose Transporter Type 2
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Subject Areas on Research
- An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans.
- Cellular engineering and gene therapy strategies for insulin replacement in diabetes.
- Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth.
- Constitutive expression of placental lactogen in pancreatic beta cells: effects on cell morphology, growth, and gene expression.
- Fructose metabolism and metabolic disease.
- GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity.
- Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter.
- Molecular strategies for the treatment of diabetes.
- Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression.
- Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion.
- PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum.
- Prolactin induction of insulin gene expression: the roles of glucose and glucose transporter-2.
- Regulation of insulin secretion from novel engineered insulinoma cell lines.
- STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells.
- Structural domains that contribute to substrate specificity in facilitated glucose transporters are distinct from those involved in kinetic function: studies with GLUT-1/GLUT-2 chimeras.
- The intestinal glucose-apelin cycle controls carbohydrate absorption in mice.
- Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism.
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Keywords of People
- Hogan, Brigid L. M., George Barth Geller Distinguished Professor for Research in Molecular Biology, Cell Biology