Glucose Transporter Type 2

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  Subject Areas on Research

  • An adenovirus vector for efficient RNA interference-mediated suppression of target genes in insulinoma cells and pancreatic islets of langerhans. 
  • Cellular engineering and gene therapy strategies for insulin replacement in diabetes. 
  • Constitutive expression of placental lactogen in pancreatic beta cells: effects on cell morphology, growth, and gene expression. 
  • Effect of GLP-2 on mucosal morphology and SGLT1 expression in tissue-engineered neointestine. 
  • Fructose metabolism and metabolic disease. 
  • GLUT-2 gene transfer into insulinoma cells confers both low and high affinity glucose-stimulated insulin release. Relationship to glucokinase activity. 
  • Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter. 
  • Molecular strategies for the treatment of diabetes. 
  • Novel insulinoma cell lines produced by iterative engineering of GLUT2, glucokinase, and human insulin expression. 
  • Overexpression of leptin receptors in pancreatic islets of Zucker diabetic fatty rats restores GLUT-2, glucokinase, and glucose-stimulated insulin secretion. 
  • PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum. 
  • Prolactin induction of insulin gene expression: the roles of glucose and glucose transporter-2. 
  • Regulation of insulin secretion from novel engineered insulinoma cell lines. 
  • STZ transport and cytotoxicity. Specific enhancement in GLUT2-expressing cells. 
  • Structural domains that contribute to substrate specificity in facilitated glucose transporters are distinct from those involved in kinetic function: studies with GLUT-1/GLUT-2 chimeras. 
  • The intestinal glucose-apelin cycle controls carbohydrate absorption in mice. 
  • Transfection of AtT-20ins cells with GLUT-2 but not GLUT-1 confers glucose-stimulated insulin secretion. Relationship to glucose metabolism. 
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  Keywords of People

  • Hogan, Brigid L. M., George Barth Geller Professor, Cell Biology