Glucose Transporter Type 4

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  Subject Areas on Research

  • 80K-H acts as a signaling bridge in intact living cells between PKCzeta and the GLUT4 translocation regulator Munc18c. 
  • A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. 
  • A potential role for glucose transporters in the evolution of human brain size. 
  • Acute interleukin-6 administration does not impair muscle glucose uptake or whole-body glucose disposal in healthy humans. 
  • Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. 
  • Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency. 
  • Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency. 
  • Chronic growth hormone treatment in normal rats reduces post-prandial skeletal muscle plasma membrane GLUT1 content, but not glucose transport or GLUT4 expression and localization. 
  • Discovery of a class of endogenous mammalian lipids with anti-diabetic and anti-inflammatory effects. 
  • Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes. 
  • Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism. 
  • Exercise increases muscle GLUT-4 levels and insulin action in subjects with impaired glucose tolerance. 
  • Identification of 80K-H as a protein involved in GLUT4 vesicle trafficking. 
  • Increased glucose disposal induced by adenovirus-mediated transfer of glucokinase to skeletal muscle in vivo. 
  • Insulin resistance and altered systemic glucose metabolism in mice lacking Nur77. 
  • Insulin-triggered repositioning of munc18c on syntaxin-4 in GLUT4 signalling. 
  • Metabolism: A is for adipokine. 
  • Muscle glycogen content and glucose uptake during exercise in humans: influence of prior exercise and dietary manipulation. 
  • Protein kinase-zeta interacts with munc18c: role in GLUT4 trafficking. 
  • Purinergic receptor X7 mediates leptin induced GLUT4 function in stellate cells in nonalcoholic steatohepatitis. 
  • Substrate availability and transcriptional regulation of metabolic genes in human skeletal muscle during recovery from exercise. 
  • The Effect of Vigorous- Versus Moderate-Intensity Aerobic Exercise on Insulin Action. 
  • The HO-1/CO system regulates mitochondrial-capillary density relationships in human skeletal muscle. 
  • The Krüppel-like factor KLF15 regulates the insulin-sensitive glucose transporter GLUT4. 
  • beta -Arrestin-mediated recruitment of the Src family kinase Yes mediates endothelin-1-stimulated glucose transport. 
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  Keywords of People

  • Wray, Gregory Allan, Professor of Biology, Duke Innovation & Entrepreneurship