Wiskott-Aldrich Syndrome Protein
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Subject Areas on Research
- A Dictyostelium homologue of WASP is required for polarized F-actin assembly during chemotaxis.
- A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast.
- Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein.
- An attenuating role of a WASP-related protein, WASP-B, in the regulation of F-actin polymerization and pseudopod formation via the regulation of RacC during Dictyostelium chemotaxis.
- Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization.
- In vitro reconstitution of cortical actin assembly sites in budding yeast.
- Regulation of the formation and trafficking of vesicles from Golgi by PCH family proteins during chemotaxis.
- Role of RacC for the regulation of WASP and phosphatidylinositol 3-kinase during chemotaxis of Dictyostelium.
- Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis.
- SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development.
- Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro.
- X inactivation in females with X-linked disease.
- X-Linked syndrome of polyendocrinopathy, immune dysfunction, and diarrhea maps to Xp11.23-Xq13.3.