Wiskott-Aldrich Syndrome Protein

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  Subject Areas on Research

  • A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast. 
  • Activation of the yeast Arp2/3 complex by Bee1p, a WASP-family protein. 
  • Direct involvement of yeast type I myosins in Cdc42-dependent actin polymerization. 
  • In vitro reconstitution of cortical actin assembly sites in budding yeast. 
  • Role of Scd5, a protein phosphatase-1 targeting protein, in phosphoregulation of Sla1 during endocytosis. 
  • SCAR, a WASP-related protein, isolated as a suppressor of receptor defects in late Dictyostelium development. 
  • Saccharomyces cerevisiae Bzz1p is implicated with type I myosins in actin patch polarization and is able to recruit actin-polymerizing machinery in vitro. 
  • X inactivation in females with X-linked disease. 
  • X-Linked syndrome of polyendocrinopathy, immune dysfunction, and diarrhea maps to Xp11.23-Xq13.3.