Cortactin

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  Subject Areas on Research

  • Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. 
  • Dual roles of tight junction-associated protein, zonula occludens-1, in sphingosine 1-phosphate-mediated endothelial chemotaxis and barrier integrity. 
  • HDAC6 modulates cell motility by altering the acetylation level of cortactin. 
  • Loss of deacetylation activity of Hdac6 affects emotional behavior in mice. 
  • Sphingosine-1-phosphate signaling regulates lamellipodia localization of cortactin complexes in endothelial cells.