Mice

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  Subject Areas on Research

  • "Model" behavior. 
  • "Silent" NMDA Synapses Enhance Motion Sensitivity in a Mature Retinal Circuit. 
  • 'Chimeric' grafts assembled from multiple allodisparate donors enjoy enhanced transplant survival. 
  • 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. 
  • (2S)-2-(3-(1-Carboxy-5-(4-211At-Astatobenzamido)Pentyl)Ureido)-Pentanedioic Acid for PSMA-Targeted α-Particle Radiopharmaceutical Therapy. 
  • (4-[18F]fluoro-3-iodobenzyl)guanidine, a potential MIBG analogue for positron emission tomography. 
  • (Aryloxy)aryl semicarbazones and related compounds: a novel class of anticonvulsant agents possessing high activity in the maximal electroshock screen. 
  • 1 alpha,25 Dihydroxyvitamin D3 and mononuclear phagocytes: enhancement of mouse macrophage and human monocyte hydrogen peroxide production without alteration of tumor cytolysis. 
  • 1,2,4-Trioxanes as potential antimalarial agents. 
  • 1-(m-[211At]astatobenzyl)guanidine: synthesis via astato demetalation and preliminary in vitro and in vivo evaluation. 
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced astrogliosis does not require activation of ornithine decarboxylase. 
  • 125I-labeled anti-epidermal growth factor receptor-vIII single-chain Fv exhibits specific and high-level targeting of glioma xenografts. 
  • 131I-labeled Anti-HER2 Camelid sdAb as a Theranostic Tool in Cancer Treatment. 
  • 14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening. 
  • 17beta-Nitro-5alpha-androstan-3alpha-ol and its 3beta-methyl derivative: neurosteroid analogs with potent anticonvulsant and anxiolytic activities. 
  • 17beta-estradiol differentially activates mitogen-activated protein-kinases and improves survival following reperfusion injury of reduced-size liver in mice. 
  • 2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity. 
  • 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) induces peripheral blood abnormalities and plasma cell neoplasms resembling multiple myeloma in mice. 
  • 2-O, 3-O-desulfated heparin inhibits neutrophil elastase-induced HMGB-1 secretion and airway inflammation. 
  • 211At radiocolloid therapy: further observations and comparison with radiocolloids of 32P, 165Dy, and 90Y. 
  • 211At- and 131I-labeled bisphosphonates with high in vivo stability and bone accumulation. 
  • 25-Hydroxycholesterol amplifies microglial IL-1β production in an apoE isoform-dependent manner. 
  • 27-Hydroxycholesterol Impairs Plasma Membrane Lipid Raft Signaling as Evidenced by Inhibition of IL6-JAK-STAT3 Signaling in Prostate Cancer Cells. 
  • 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. 
  • 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis. 
  • 3'UTR shortening of HAS2 promotes hyaluronan hyper-synthesis and bioenergetic dysfunction in pulmonary hypertension. 
  • 3,4-Diaminopyridine (DAP) in the treatment of Lambert-Eaton myasthenic syndrome (LEMS). 
  • 3-D Adaptive Sparsity Based Image Compression with Applications to Optical Coherence Tomography 
  • 3-Halo-5,7-dimethylpyrazolo [1,5-a]pyrimidines, a nonbenzodiazepinoid class of antianxiety agents devoid of potentiation of central nervous system depressant effects of ethanol or barbiturates. 
  • 3-[211At]astato-4-fluorobenzylguanidine: a potential therapeutic agent with prolonged retention by neuroblastoma cells. 
  • 3D cardiac μtissues within a microfluidic device with real-time contractile stress readout. 
  • 3D fiber tractography with susceptibility tensor imaging. 
  • 3D model of frequency representation in the cochlear nucleus of the CBA/J mouse. 
  • 3D printing of high-strength, porous, elastomeric structures to promote tissue integration of implants. 
  • 3He MRI in mouse models of asthma. 
  • 4-1BB Agonism Averts TIL Exhaustion and Licenses PD-1 Blockade in Glioblastoma and Other Intracranial Cancers. 
  • 4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice. 
  • 4-D micro-CT of the mouse heart. 
  • 4.5 kb of the rat tyrosine hydroxylase 5' flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors. 
  • 440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons. 
  • 4D MRI of polycystic kidneys from rapamycin-treated Glis3-deficient mice. 
  • 4D micro-CT for cardiac and perfusion applications with view under sampling. 
  • 4D micro-CT using fast prospective gating. 
  • 5' UTR m(6)A Promotes Cap-Independent Translation. 
  • 5' flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice. 
  • 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. 
  • 5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice. 
  • 5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain. 
  • 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. 
  • 5α-Reductase inhibition coupled with short off cycles increases survival in the LNCaP xenograft prostate tumor model on intermittent androgen deprivation therapy. 
  • miR-146a -Traf6 regulatory axis controls autoimmunity and myelopoiesis, but is dispensable for hematopoietic stem cell homeostasis and tumor suppression. 
  • A 1.3 kb promoter fragment confers spatial and temporal expression of utrophin A mRNA in mouse skeletal muscle fibers. 
  • A 10-gene progenitor cell signature predicts poor prognosis in lung adenocarcinoma. 
  • A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. 
  • A 4-methyl-substituted meta-iodobenzylguanidine analogue with prolonged retention in human neuroblastoma cells. 
  • A 40-kilodalton protein binds specifically to an upstream sequence element essential for muscle-specific transcription of the human myoglobin promoter. 
  • A 57,000-mol-wt protein uniquely present in nonproliferating cells and senescent human fibroblasts. 
  • A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. 
  • A Bayesian approach for joint modeling of cluster size and subunit-specific outcomes. 
  • A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. 
  • A CNS catecholaminergic cell line expresses voltage-gated currents. 
  • A CRISPR-Cas system enhances envelope integrity mediating antibiotic resistance and inflammasome evasion. 
  • A CRISPR/Cas9-based system for reprogramming cell lineage specification. 
  • A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. 
  • A Circle RNA Regulatory Axis Promotes Lung Squamous Metastasis via CDR1-Mediated Regulation of Golgi Trafficking. 
  • A Combination of Ontogeny and CNS Environment Establishes Microglial Identity. 
  • A Commencement for Eye Commensals. 
  • A Common Neuroendocrine Substrate for Diverse General Anesthetics and Sleep. 
  • A Cyp2a polymorphism predicts susceptibility to NNK-induced lung tumorigenesis in mice. 
  • A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo. 
  • A Diffusion MRI Tractography Connectome of the Mouse Brain and Comparison with Neuronal Tracer Data. 
  • A Distinct Function of Regulatory T Cells in Tissue Protection. 
  • A Fas-associated death domain protein/caspase-8-signaling axis promotes S-phase entry and maintains S6 kinase activity in T cells responding to IL-2. 
  • A Fatty Acid Oxidation-dependent Metabolic Shift Regulates the Adaptation of BRAF-mutated Melanoma to MAPK Inhibitors. 
  • A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma. 
  • A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo. 
  • A Fluorometric Method of Measuring Carboxypeptidase Activities for Angiotensin II and Apelin-13. 
  • A GABAergic nigrotectal pathway for coordination of drinking behavior. 
  • A Genetically Defined Compartmentalized Striatal Direct Pathway for Negative Reinforcement. 
  • A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. 
  • A High-Throughput Organoid Microinjection Platform to Study Gastrointestinal Microbiota and Luminal Physiology. 
  • A Human Adult Stem Cell Signature Marks Aggressive Variants across Epithelial Cancers. 
  • A Human Pleiotropic Multiorgan Condition Caused by Deficient Wnt Secretion. 
  • A Knock-In Tristetraprolin (TTP) Zinc Finger Point Mutation in Mice: Comparison with Complete TTP Deficiency. 
  • A Liver-Specific Thyromimetic, VK2809, Decreases Hepatosteatosis in Glycogen Storage Disease Type Ia. 
  • A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans. 
  • A Method to Target and Isolate Airway-innervating Sensory Neurons in Mice. 
  • A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas. 
  • A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes. 
  • A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration. 
  • A Neural Circuit for Gut-Induced Reward. 
  • A Neurotrophic Mechanism Directs Sensory Nerve Transit in Cranial Bone. 
  • A Neutralizing IL-11 Antibody Improves Renal Function and Increases Lifespan in a Mouse Model of Alport Syndrome. 
  • A New, Second Generation Trithiol Bifunctional Chelate for 72,77As: Trithiol(b)-(Ser)2-RM2. 
  • A Non-Canonical Role for β-Secretase in the Retina. 
  • A Novel Murine Model of Marfan Syndrome Accelerates Aortopathy and Cardiomyopathy. 
  • A Novel Mycovirus Evokes Transcriptional Rewiring in the Fungus Malassezia and Stimulates Beta Interferon Production in Macrophages. 
  • A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus. 
  • A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. 
  • A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer. 
  • A PRDM16-Driven Metabolic Signal from Adipocytes Regulates Precursor Cell Fate. 
  • A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus. 
  • A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period. 
  • A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy. 
  • A Precision Medicine Drug Discovery Pipeline Identifies Combined CDK2 and 9 Inhibition as a Novel Therapeutic Strategy in Colorectal Cancer. 
  • A Prevalent Focused Human Antibody Response to the Influenza Virus Hemagglutinin Head Interface. 
  • A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues. 
  • A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells. 
  • A RIPK3-caspase 8 complex mediates atypical pro-IL-1β processing. 
  • A Rare Mutation of β1-Adrenergic Receptor Affects Sleep/Wake Behaviors. 
  • A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans. 
  • A Rationally Designed Fully Human EGFRvIII:CD3-Targeted Bispecific Antibody Redirects Human T Cells to Treat Patient-derived Intracerebral Malignant Glioma. 
  • A Regenerative Cardiac Patch Formed by Spray Painting of Biomaterials onto the Heart. 
  • A Requirement of Protein Geranylgeranylation for Chemokine Receptor Signaling and Th17 Cell Function in an Animal Model of Multiple Sclerosis. 
  • A Roadmap to Heart Regeneration Through Conserved Mechanisms in Zebrafish and Mammals. 
  • A Role for Protease Activated Receptor Type 3 (PAR3) in Nociception Demonstrated Through Development of a Novel Peptide Agonist. 
  • A SMAP in the face for cancer. 
  • A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans. 
  • A Single Immunization with Nucleoside-Modified mRNA Vaccines Elicits Strong Cellular and Humoral Immune Responses against SARS-CoV-2 in Mice. 
  • A Small Molecule Inhibitor of VE-PTP Activates Tie2 in Schlemm's Canal Increasing Outflow Facility and Reducing Intraocular Pressure. 
  • A Small Molecule Targeting Mutagenic Translesion Synthesis Improves Chemotherapy. 
  • A Specialized Neural Circuit Gates Social Vocalizations in the Mouse. 
  • A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. 
  • A TAZ-AXL-ABL2 Feed-Forward Signaling Axis Promotes Lung Adenocarcinoma Brain Metastasis. 
  • A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion. 
  • A TRPA1-dependent mechanism for the pungent sensation of weak acids. 
  • A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo. 
  • A Virion-Based Combination Vaccine Protects against Influenza and SARS-CoV-2 Disease in Mice. 
  • A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. 
  • A Western diet induced NAFLD in LDLR(-/)(-) mice is associated with reduced hepatic glutathione synthesis. 
  • A Wor1-Like Transcription Factor Is Essential for Virulence of Cryptococcus neoformans. 
  • A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels. 
  • A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locus. 
  • A beta-arrestin 2 signaling complex mediates lithium action on behavior. 
  • A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. 
  • A bidirectional phage display vector for the selection and mass transfer of polyclonal antibody libraries. 
  • A binding site for Pax proteins regulates expression of the gene for the neural cell adhesion molecule in the embryonic spinal cord. 
  • A bioactive titanium foam scaffold for bone repair. 
  • A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins. 
  • A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans. 
  • A brief history of tissue models for cardiac electrophysiology. 
  • A broadly cross-reactive antibody neutralizes and protects against sarbecovirus challenge in mice. 
  • A c-Fos- and E1A-interacting component of the tissue factor basal promoter complex mediates synergistic activation of transcription by transforming growth factor-beta1. 
  • A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice. 
  • A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. 
  • A cancer rainbow mouse for visualizing the functional genomics of oncogenic clonal expansion. 
  • A candidate taste receptor gene near a sweet taste locus. 
  • A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. 
  • A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 
  • A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation. 
  • A cell-intrinsic role for Mst1 in regulating thymocyte egress. 
  • A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. 
  • A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. 
  • A cell-specific nuclear receptor regulates the steroid hydroxylases. 
  • A central role for Foxp3+ regulatory T cells in K-Ras-driven lung tumorigenesis. 
  • A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice. 
  • A chemical glycoproteomics platform reveals O-GlcNAcylation of mitochondrial voltage-dependent anion channel 2. 
  • A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. 
  • A circuit for motor cortical modulation of auditory cortical activity. 
  • A circuit model for saccadic suppression in the superior colliculus. 
  • A class of viral inducer of degradation of the necroptosis adaptor RIPK3 regulates virus-induced inflammation. 
  • A cluster of virus-encoded microRNAs accelerates acute systemic Epstein-Barr virus infection but does not significantly enhance virus-induced oncogenesis in vivo. 
  • A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection. 
  • A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. 
  • A common single nucleotide polymorphism A118G of the μ opioid receptor alters its N-glycosylation and protein stability. 
  • A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome. 
  • A comparative analysis of EGFR-targeting antibodies for gold nanoparticle CT imaging of lung cancer. 
  • A comparative study of the distributions of renin and angiotensinogen messenger ribonucleic acids in rat and mouse tissues. 
  • A comparison of antiangiogenic therapies for the prevention of liver metastases. 
  • A comparison of least squares and conditional maximum likelihood estimators under volume endpoint censoring in tumor growth experiments. 
  • A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution. 
  • A comparison of non-toxin vaccine adjuvants for their ability to enhance the immunogenicity of nasally-administered anthrax recombinant protective antigen. 
  • A comparison of oral and rectal absorption of L-dopa esters in rats and mice. 
  • A comparison of radial keyhole strategies for high spatial and temporal resolution 4D contrast-enhanced MRI in small animal tumor models. 
  • A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia. 
  • A comparison of the genes coding for canonical TRP channels and their M, V and P relatives. 
  • A complex of distal appendage-associated kinases linked to human disease regulates ciliary trafficking and stability. 
  • A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. 
  • A comprehensive method for optical-emission computed tomography. 
  • A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. 
  • A computer model of engineered cardiac monolayers. 
  • A computer program for displaying two-dimensional gel electrophoresis data. 
  • A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. 
  • A conserved retromer-independent function for RAB-6.2 in C. elegans epidermis integrity. 
  • A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. 
  • A controlled-release strategy for the generation of cross-linked hydrogel microstructures. 
  • A cord blood monocyte-derived cell therapy product accelerates brain remyelination. 
  • A cortical circuit for gain control by behavioral state. 
  • A cortical filter that learns to suppress the acoustic consequences of movement. 
  • A cortico-hippocampal learning rule shapes inhibitory microcircuit activity to enhance hippocampal information flow. 
  • A craniofacial-specific monosynaptic circuit enables heightened affective pain. 
  • A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154-independent rejection. 
  • A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism. 
  • A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation. 
  • A critical role for the autophagy gene Atg5 in T cell survival and proliferation. 
  • A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses. 
  • A crucial role of L-selectin in C protein-induced experimental polymyositis in mice. 
  • A cut above the other caspases. 
  • A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. 
  • A cytogenetic comparison of the responses of mouse and human peripheral blood lymphocytes to 60Co gamma radiation. 
  • A cytokine cocktail directly modulates the phenotype of DC-enriched anti-tumor T cells to convey potent anti-tumor activities in a murine model. 
  • A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene. 
  • A defect in the humoral immune response to protein antigens and haptens in immunoglobulin mu heavy-chain transgenic mice. 
  • A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice. 
  • A depot-forming glucagon-like peptide-1 fusion protein reduces blood glucose for five days with a single injection. 
  • A designed glycoprotein analogue of Gc-MAF exhibits native-like phagocytic activity. 
  • A developmental switch from TCR delta enhancer to TCR alpha enhancer function during thymocyte maturation. 
  • A differential role for endocytosis in receptor-mediated activation of Nox1. 
  • A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program. 
  • A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus. 
  • A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires. 
  • A disinhibitory circuit mediates motor integration in the somatosensory cortex. 
  • A diverse population of Cryptococcus gattii molecular type VGIII in southern Californian HIV/AIDS patients. 
  • A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR. 
  • A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. 
  • A dual-emissive-materials design concept enables tumour hypoxia imaging. 
  • A family of candidate taste receptors in human and mouse. 
  • A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery. 
  • A feasibility study using radiochromic films for fast neutron 2D passive dosimetry. 
  • A fixative for use in muscle histochemistry. 
  • A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. 
  • A fluorescent assay for agonist-activated phospholipase D in mammalian cell extracts. 
  • A fluorogenic C. neoformans reporter strain with a robust expression of m-cherry expressed from a safe haven site in the genome. 
  • A functional analysis of the spacer of V(D)J recombination signal sequences. 
  • A functional genomics predictive network model identifies regulators of inflammatory bowel disease. 
  • A functional mouse ornithine decarboxylase gene (Odc) maps to chromosome 12: further evidence of homoeology between mouse chromosome 12 and the short arm of human chromosome 2. 
  • A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. 
  • A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer. 
  • A futile metabolic cycle activated in adipocytes by antidiabetic agents. 
  • A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. 
  • A gene atlas of the mouse and human protein-encoding transcriptomes. 
  • A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. 
  • A general approach for two-stage analysis of multilevel clustered non-Gaussian data. 
  • A genetic approach for studying the physiology of the type 1A (AT1A) angiotensin receptor. 
  • A genetically defined disease model reveals that urothelial cells can initiate divergent bladder cancer phenotypes. 
  • A genetically defined normal human somatic cell system to study ras oncogenesis in vivo and in vitro. 
  • A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation. 
  • A genetically modified allogeneic cellular vaccine generates MHC class I-restricted cytotoxic responses against tumor-associated antigens and protects against CNS tumors in vivo. 
  • A genetically tractable model of human glioma formation. 
  • A genome end-game: understanding gene function in the nervous system. 
  • A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. 
  • A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25. 
  • A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. 
  • A glutaminase isoform switch drives therapeutic resistance and disease progression of prostate cancer. 
  • A glycoengineered anti-CD19 antibody with potent antibody-dependent cellular cytotoxicity activity in vitro and lymphoma growth inhibition in vivo. 
  • A grafted ovarian fragment rescues host fertility after chemotherapy. 
  • A guide to analysis of mouse energy metabolism. 
  • A gut-brain neural circuit for nutrient sensory transduction. 
  • A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration. 
  • A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. 
  • A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity. 
  • A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer. 
  • A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders. 
  • A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. 
  • A high-performance liquid chromatography method for the quantification of cysmethynil, an inhibitor of isoprenylcysteine carboxylmethyl transferase, in mouse plasma. 
  • A high-precision contrast injector for small animal x-ray digital subtraction angiography. 
  • A high-resolution anatomical ontology of the developing murine genitourinary tract. 
  • A high-temperature superconducting Helmholtz probe for microscopy at 9.4 T. 
  • A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent. 
  • A highly polarized TH2 bladder response to infection promotes epithelial repair at the expense of preventing new infections. 
  • A highly selective Hsp90 affinity chromatography resin with a cleavable linker. 
  • A human CD46 transgenic pig model system for the study of discordant xenotransplantation. 
  • A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation. 
  • A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice. 
  • A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. 
  • A humanized mouse model to study mast cells mediated cutaneous adverse drug reactions. 
  • A hypothetic mechanism of diethylstilbestrol(DES)-induced anomalies in exposed progeny. 
  • A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. 
  • A large U3 deletion causes increased in vivo expression from a nonintegrating lentiviral vector. 
  • A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. 
  • A liposomal nanoscale contrast agent for preclinical CT in mice. 
  • A local hyperthermia treatment which enhances antibody uptake in a glioma xenograft model does not affect tumour interstitial fluid pressure. 
  • A locus mapping to mouse chromosome 7 determines infarct volume in a mouse model of ischemic stroke. 
  • A long-acting formulation of rifabutin is effective for prevention and treatment of Mycobacterium tuberculosis. 
  • A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection. 
  • A lytic polysaccharide monooxygenase-like protein functions in fungal copper import and meningitis. 
  • A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury. 
  • A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus. 
  • A major role for the EP4 receptor in regulation of renin. 
  • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. 
  • A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness. 
  • A mastoparan-derived peptide has broad-spectrum antiviral activity against enveloped viruses. 
  • A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites. 
  • A mechanism for expansion of regulatory T-cell repertoire and its role in self-tolerance. 
  • A mechanism for gene-environment interaction in the etiology of congenital scoliosis. 
  • A mechanism-based antioxidant approach for the reduction of skin carcinogenesis. 
  • A mechanism-based complementary screening approach for the amelioration and reversal of neurobehavioral teratogenicity. 
  • A member of a family of sulfate-activating enzymes causes murine brachymorphism. 
  • A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors. 
  • A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. 
  • A metalloporphyrin antioxidant alters cytokine responses after irradiation in a prostate tumor model. 
  • A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. 
  • A method for linking VL and VH region genes that allows bulk transfer between vectors for use in generating polyclonal IgG libraries. 
  • A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine. 
  • A methodology for utilization of predictive genomic signatures in FFPE samples. 
  • A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer. 
  • A micro-CT analysis of murine lung recruitment in bleomycin-induced lung injury. 
  • A micro-computed tomography-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice. 
  • A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation. 
  • A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation. 
  • A microfluidic system for investigation of extravascular transport and cellular uptake of drugs in tumors. 
  • A mitotic recombination system for mouse chromosome 17. 
  • A model for RAS mutation patterns in cancers: finding the sweet spot. 
  • A model for human medulloblastoma. Growth, morphology, and chromosomal analysis in vitro and in athymic mice. 
  • A model for optimizing adenoviral delivery in human cancer gene therapy trials. 
  • A model of muscle atrophy using cast immobilization in mice. 
  • A modern Cosmas and Damian: Sir Roy Calne and Thomas Starzl receive the 2012 Lasker~Debakey Clinical Medical Research Award. 
  • A modified vaccinia Ankara vector-based vaccine protects macaques from SARS-CoV-2 infection, immune pathology, and dysfunction in the lungs. 
  • A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation. 
  • A monoclonal antibody reactive with a second epitope of the 67,000-dalton human T cell antigen. 
  • A monoclonal antibody specific for the amino terminal sequence of human prorenin identifies a common epitope on renal and amniotic fluid inactive renins. 
  • A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief. 
  • A morphological analysis endocrine tumour genesis in pancreas and anterior pituitary of AVP/SV40 transgenic mice. 
  • A mosaic analysis system with Cre or Tomato expression in the mouse. 
  • A mouse bleeding model to study oral anticoagulants. 
  • A mouse homoeo box gene is expressed during embryogenesis and in adult kidney. 
  • A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. 
  • A mouse macrophage lipidome. 
  • A mouse model for heparin-induced thrombocytopenia. 
  • A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2. 
  • A mouse model of adult-onset anaemia due to erythropoietin deficiency. 
  • A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5. 
  • A mouse model of familial porphyria cutanea tarda. 
  • A mouse model of heart failure with preserved ejection fraction due to chronic infusion of a low subpressor dose of angiotensin II. 
  • A mouse model of higher visual cortical function. 
  • A mouse model of juvenile hemochromatosis. 
  • A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer. 
  • A multigene family encoding a diverse array of putative pheromone receptors in mammals. 
  • A multimodal cell census and atlas of the mammalian primary motor cortex. 
  • A multimodal micro-optrode combining field and single unit recording, multispectral detection and photolabeling capabilities. 
  • A murine Ig light chain transgene reveals IGKV3 gene contributions to anti-collagen types IV and II specificities. 
  • A murine model for short-chain acyl-CoA dehydrogenase deficiency. 
  • A murine model of congenital toxoplasmic retinochoroiditis. 
  • A murine model of hyperdopaminergic state displays altered respiratory control. 
  • A murine model of increased coronary sinus pressure induces myocardial edema with cardiac lymphatic dilation and fibrosis. 
  • A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice. 
  • A mutant PTH/PTHrP type I receptor in enchondromatosis. 
  • A mutant form of p135tyk2, an interferon-alpha inducible tyrosine kinase, suppresses the transformed phenotype of Daudi cells. 
  • A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. 
  • A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. 
  • A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy. 
  • A near-infrared genetically encoded calcium indicator for in vivo imaging. 
  • A network of genetic events sufficient to convert normal human cells to a tumorigenic state. 
  • A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. 
  • A neural circuit for spatial summation in visual cortex. 
  • A neural network-based method for spectral distortion correction in photon counting x-ray CT. 
  • A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency. 
  • A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury. 
  • A neutralizing epitope of the superantigen SEA has agonist activity on T cells. 
  • A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme. 
  • A new EV71 VP3 epitope in norovirus P particle vector displays neutralizing activity and protection in vivo in mice. 
  • A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity. 
  • A new activating role for CO in cardiac mitochondrial biogenesis. 
  • A new method for the cytological analysis of autoantibody specificities using whole-mount, surface-spread meiotic nuclei. 
  • A new model of Epstein-Barr virus infection reveals an important role for early lytic viral protein expression in the development of lymphomas. 
  • A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and alpha 2-macroglobulin. 
  • A new role for ATM: regulating mitochondrial function and mitophagy. 
  • A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase. 
  • A new synthetic protectin D1 analog 3-oxa-PD1n-3 DPA reduces neuropathic pain and chronic itch in mice. 
  • A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model. 
  • A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. 
  • A no-laminectomy spinal cord compression injury model in mice. 
  • A non-oncogenic HPV 16 E6/E7 vaccine enhances treatment of HPV expressing tumors. 
  • A nonantigenic covalent streptokinase-polyethylene glycol complex with plasminogen activator function. 
  • A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice. 
  • A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1. 
  • A novel Cbx1, PurB, and Sp3 complex mediates long-term silencing of tissue- and lineage-specific genes. 
  • A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. 
  • A novel EGFR isoform confers increased invasiveness to cancer cells. 
  • A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization. 
  • A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity. 
  • A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage. 
  • A novel approach to maintain gut mucosal integrity using an oral enzyme supplement. 
  • A novel basal promoter element is required for expression of the rat tyrosine hydroxylase gene. 
  • A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase. 
  • A novel conditionally replicating "armed" adenovirus selectively targeting gastrointestinal tumors with aberrant wnt signaling. 
  • A novel flow-perfusion bioreactor supports 3D dynamic cell culture. 
  • A novel genetic locus modulates infarct volume independently of the extent of collateral circulation. 
  • A novel human endometrial epithelial cell line for modeling gynecological diseases and for drug screening. 
  • A novel immune competent murine hypertrophic scar contracture model: a tool to elucidate disease mechanism and develop new therapies. 
  • A novel immunocompetent murine tumor model for the evaluation of RCAd-enhanced RDAd transduction efficacy. 
  • A novel in vitro assay of tumor-initiating cells in xenograft prostate tumors. 
  • A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells. 
  • A novel intracellular protein delivery platform based on single-protein nanocapsules 
  • A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation. 
  • A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. 
  • A novel mechanism of skin tumor promotion involving interferon-gamma (IFNγ)/signal transducer and activator of transcription-1 (Stat1) signaling. 
  • A novel method for viral gene delivery in solid tumors. 
  • A novel mitochondrial matrix serine/threonine protein phosphatase regulates the mitochondria permeability transition pore and is essential for cellular survival and development. 
  • A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis. 
  • A novel modifier gene for plasma von Willebrand factor level maps to distal mouse chromosome 11. 
  • A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. 
  • A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury. 
  • A novel mouse model of podocyte depletion. 
  • A novel mouse model of red blood cell storage and posttransfusion in vivo survival. 
  • A novel murine model of human renal cell carcinoma spinal metastasis. 
  • A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features. 
  • A novel murine oncornavirus with dual eco- and xenotropic properties. 
  • A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase. 
  • A novel mutation in the erythropoietin receptor gene is associated with familial erythrocytosis. 
  • A novel neoplastic primary tumor-derived human prostate epithelial cell line. 
  • A novel neurotoxoid vaccine prevents mucosal botulism. 
  • A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling. 
  • A novel redox regulator, MnTnBuOE-2-PyP5+, enhances normal hematopoietic stem/progenitor cell function. 
  • A novel rodent mammary window of orthotopic breast cancer for intravital microscopy. 
  • A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis. 
  • A novel role for activation-induced cytidine deaminase: central B-cell tolerance. 
  • A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension. 
  • A novel species-specific RNA related to alternatively spliced amyloid precursor protein mRNAs. 
  • A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury. 
  • A novel toll-like receptor 9 agonist cooperates with trastuzumab in trastuzumab-resistant breast tumors through multiple mechanisms of action. 
  • A novel, clinically relevant animal model of metastatic pancreatic adenocarcinoma biology and therapy. 
  • A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression. 
  • A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases. 
  • A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models. 
  • A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. 
  • A peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase regulatory subunit: a novel cancer therapy. 
  • A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death. 
  • A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas. 
  • A phase I-II study evaluating the murine anti-IL-2 receptor antibody 2A3 for treatment of acute graft-versus-host disease. 
  • A piggyBac insertion disrupts Foxl2 expression that mimics BPES syndrome in mice. 
  • A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost. 
  • A point mutation (D79N) of the alpha2A adrenergic receptor abolishes the antiepileptogenic action of endogenous norepinephrine. 
  • A portable ventilator with integrated physiologic monitoring for hyperpolarized 129Xe MRI in rodents. 
  • A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair. 
  • A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers. 
  • A preliminary investigation of the parallelogram concept in genetic monitoring and risk estimation. 
  • A preliminary study on efficacy of rupatadine for the treatment of acute dengue infection. 
  • A primary role for K+ and Na+ efflux in the activation of apoptosis. 
  • A prior feature SVM-MRF based method for mouse brain segmentation. 
  • A probabilistic approach to demixing odors. 
  • A procedure for the preferential radioiodination of small amounts of protein in the presence of excess lipids. 
  • A proposal for a coordinated effort for the determination of brainwide neuroanatomical connectivity in model organisms at a mesoscopic scale. 
  • A protective Hsp70-TLR4 pathway in lethal oxidant lung injury. 
  • A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. 
  • A proteomic approach for dissecting H-Ras signaling networks in NIH/3T3 mouse embryonic fibroblast cells. 
  • A proteomic approach for unraveling the oncogenic H-Ras protein networks in NIH/3T3 mouse embryonic fibroblast cells. 
  • A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. 
  • A protocol for heterologous expression and functional assay for mouse pheromone receptors. 
  • A quantitative map of the liver mitochondrial phosphoproteome reveals posttranslational control of ketogenesis. 
  • A quantitative microscopic approach to predict local recurrence based on in vivo intraoperative imaging of sarcoma tumor margins. 
  • A quantitative trait locus (LSq-1) on mouse chromosome 7 is linked to the absence of tissue loss after surgical hindlimb ischemia. 
  • A rapid cytoplasmic mechanism for PI3 kinase regulation by the nuclear thyroid hormone receptor, TRβ, and genetic evidence for its role in the maturation of mouse hippocampal synapses in vivo. 
  • A rapidly dividing human medulloblastoma cell line (D283 MED) expresses all three neurofilament subunits. 
  • A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. 
  • A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with Jak1 and is sufficient to activate the Jak-Stat pathway and induce an antiviral state. 
  • A registration based approach for 4D cardiac micro-CT using combined prospective and retrospective gating. 
  • A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. 
  • A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation. 
  • A resource of Cre driver lines for genetic targeting of GABAergic neurons in cerebral cortex. 
  • A reversible aptamer improves outcome and safety in murine models of stroke and hemorrhage. 
  • A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. 
  • A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI. 
  • A rodent model of spontaneous stereotypy: initial characterization of developmental, environmental, and neurobiological factors. 
  • A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. 
  • A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation. 
  • A role for E2F activities in determining the fate of Myc-induced lymphomagenesis. 
  • A role for MAPK in feedback inhibition of Tcrb recombination. 
  • A role for Pin1 in mammalian germ cell development and spermatogenesis. 
  • A role for Sfrp2 in cardiomyogenesis in vivo. 
  • A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. 
  • A role for TREK1 in generating the slow afterhyperpolarization in developing starburst amacrine cells. 
  • A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation. 
  • A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension. 
  • A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes. 
  • A role for cFLIP in B cell proliferation and stress MAPK regulation. 
  • A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. 
  • A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection. 
  • A role for histone acetylation in the developmental regulation of VDJ recombination. 
  • A role for immunogenic DNA in the pathogenesis of systemic lupus erythematosus. 
  • A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth. 
  • A role for the CD38 rs3796863 polymorphism in alcohol and monetary reward: evidence from CD38 knockout mice and alcohol self-administration, [11C]-raclopride binding, and functional MRI in humans. 
  • A role for the copper transporter Ctr1 in the synergistic interaction between hyperthermia and cisplatin treatment. 
  • A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection. 
  • A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. 
  • A role for the thromboxane receptor in L-NAME hypertension. 
  • A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation. 
  • A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. 
  • A role for ΔFosB in calorie restriction-induced metabolic changes. 
  • A role of matrix metalloproteinase-8 in atherosclerosis. 
  • A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice. 
  • A scanning electron microscope study of the extraembryonic endoderm of the 8th-day mouse embryo. 
  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. 
  • A self-adjuvanting supramolecular vaccine carrying a folded protein antigen. 
  • A self-assembling peptide acting as an immune adjuvant. 
  • A seminal finding for prostate cancer? 
  • A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. 
  • A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. 
  • A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. 
  • A serially transplantable human giant cell glioblastoma that maintains a near-haploid stem line. 
  • A shared vision. 
  • A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. 
  • A simple and enzyme-free method for processing infiltrating lymphocytes from small mouse tumors for ELISpot analysis. 
  • A simple, efficient tool for assessment of mice after unilateral cortex injury. 
  • A simplified synthesis of the hypoxia imaging agent 2-(2-Nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-[(18)F]pentafluoropropyl)-acetamide ([18F]EF5). 
  • A single amino acid change in the cytoplasmic domain of the simian immunodeficiency virus transmembrane molecule increases envelope glycoprotein expression on infected cells. 
  • A single genetic locus determines the efficacy of serum therapy against murine adenocarcinoma 755a. 
  • A single valine residue plays an essential role in peripherin/rds targeting to photoreceptor outer segments. 
  • A small molecule targeting ALOX12-ACC1 ameliorates nonalcoholic steatohepatitis in mice and macaques. 
  • A small regulatory element from chromosome 19 enhances liver-specific gene expression. 
  • A small-molecule antagonist of the hedgehog signaling pathway. 
  • A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. 
  • A spatially and temporally restricted mouse model of soft tissue sarcoma. 
  • A spatially resolved brain region- and cell type-specific isoform atlas of the postnatal mouse brain. 
  • A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype. 
  • A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. 
  • A statin-regulated microRNA represses human c-Myc expression and function. 
  • A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression. 
  • A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. 
  • A striatal interneuron circuit for continuous target pursuit. 
  • A study of cataract in murine congenital toxoplasmosis. 
  • A study of dendritic and endothelial cell interactions in colon cancer in a cell line and small mammal model. 
  • A subgroup of murine monoclonal anti-deoxyribonucleic acid antibodies traverse the cytoplasm and enter the nucleus in a time-and temperature- dependent manner. 
  • A symmetrical Waxholm canonical mouse brain for NeuroMaps. 
  • A synaptic and circuit basis for corollary discharge in the auditory cortex. 
  • A synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma model. 
  • A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo. 
  • A systematic review of methodology applied during preclinical anesthetic neurotoxicity studies: important issues and lessons relevant to the design of future clinical research. 
  • A systems genetics approach identifies Trp53inp2 as a link between cardiomyocyte glucose utilization and hypertrophic response. 
  • A tamoxifen inducible knock-in allele for investigation of E2A function. 
  • A targeted and adjuvanted nanocarrier lowers the effective dose of liposomal amphotericin B and enhances adaptive immunity in murine cutaneous leishmaniasis. 
  • A technique for serial spermatozoa collection in mice. 
  • A telomerase-immortalized primary human prostate cancer clonal cell line with neoplastic phenotypes. 
  • A tenascin knockout with a phenotype. 
  • A threshold for central T cell tolerance to an inducible serum protein 
  • A time-course study of actively stained mouse brains: Diffusion tensor imaging parameters and connectomic stability over 1 year. 
  • A timecourse analysis of systemic and gonadal effects of temperature on sexual development of the red-eared slider turtle Trachemys scripta elegans. 
  • A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis. 
  • A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line. 
  • A transcriptional signature accurately identifies Aspergillus Infection across healthy and immunosuppressed states. 
  • A transcriptomic and epigenomic cell atlas of the mouse primary motor cortex. 
  • A transformation from temporal to ensemble coding in a model of piriform cortex. 
  • A transgenic DND1GFP fusion allele reports in vivo expression and RNA-binding targets in undifferentiated mouse germ cells†. 
  • A transgenic mouse prostate cancer model. 
  • A transgenic toolkit for visualizing and perturbing microtubules reveals unexpected functions in the epidermis. 
  • A translatable predictor of human radiation exposure. 
  • A translational bridge between mouse and human models of learned safety. 
  • A trithiol bifunctional chelate for 72,77As: A matched pair theranostic complex with high in vivo stability. 
  • A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation. 
  • A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. 
  • A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti-PD-1 immunotherapy. 
  • A two-phase innate host response to alphavirus infection identified by mRNP-tagging in vivo. 
  • A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene. 
  • A tyrosine kinase physically associates with the beta-subunit of the human IL-2 receptor. 
  • A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. 
  • A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence. 
  • A unique pathway for the plasma elimination of alpha 2-antiplasmin-protease complexes in mice. 
  • A unique role of the DNA fragmentation factor in maintaining genomic stability. 
  • A validated regulatory network for Th17 cell specification. 
  • A versatile oblique plane microscope for large-scale and high-resolution imaging of subcellular dynamics. 
  • A versatile system to record cell-cell interactions. 
  • A vital role for interleukin-21 in the control of a chronic viral infection. 
  • A wireless multi-channel recording system for freely behaving mice and rats. 
  • A20 in Myeloid Cells Protects Against Hypertension by Inhibiting Dendritic Cell-Mediated T-Cell Activation. 
  • A20 modulates lipid metabolism and energy production to promote liver regeneration. 
  • A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis. 
  • A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression. 
  • A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism. 
  • AAV CRISPR editing rescues cardiac and muscle function for 18 months in dystrophic mice. 
  • AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia. 
  • AAV-CNS matters turn from gray to white. 
  • AAV9 Edits Muscle Stem Cells in Normal and Dystrophic Adult Mice. 
  • AAV9 gene replacement therapy for respiratory insufficiency in very-long chain acyl-CoA dehydrogenase deficiency. 
  • ABC Transporter Inhibition Plus Dexamethasone Enhances the Efficacy of Convection Enhanced Delivery in H3.3K27M Mutant Diffuse Intrinsic Pontine Glioma. 
  • ABCB5 is a limbal stem cell gene required for corneal development and repair. 
  • ABCs of erythroid mitochondrial iron uptake. 
  • ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. 
  • ABL allosteric inhibitors synergize with statins to enhance apoptosis of metastatic lung cancer cells. 
  • ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia. 
  • ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling. 
  • ACE and ACE2 activity in diabetic mice. 
  • ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase. 
  • ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. 
  • ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis. 
  • ADAM10 is essential for proteolytic activation of Notch during thymocyte development. 
  • ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds. 
  • ADAM12: a genetic modifier of preclinical peripheral arterial disease. 
  • ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. 
  • AID expression during B-cell development: searching for answers. 
  • AJAP1 expression modulates glioma cell motility and correlates with tumor growth and survival. 
  • ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma. 
  • ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. 
  • ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration. 
  • ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. 
  • ALSUntangled No. 34: GM604. 
  • ALSUntangled No. 35: Hyperbaric Oxygen Therapy. 
  • ALSUntangled No. 47: RT001. 
  • AMH induces mesonephric cell migration in XX gonads. 
  • AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. 
  • AMPK and SIRT1 activation contribute to inhibition of neuroinflammation by thymoquinone in BV2 microglia. 
  • AMPK and substrate availability regulate creatine transport in cultured cardiomyocytes. 
  • ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice. 
  • ANK2 autism mutation targeting giant ankyrin-B promotes axon branching and ectopic connectivity. 
  • AP-1 and STAT mediate hyperoxia-induced gene transcription of heme oxygenase-1. 
  • APOBEC Mutagenesis Inhibits Breast Cancer Growth through Induction of T cell-Mediated Antitumor Immune Responses. 
  • APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice. 
  • APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. 
  • APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress. 
  • APOE genotype affects outcome in a murine model of sepsis: implications for a new treatment strategy. 
  • APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. 
  • APOE genotype regulates pathology and disease progression in synucleinopathy. 
  • APOE genotype-specific differences in human and mouse macrophage nitric oxide production. 
  • APOE genotype-specific differences in the innate immune response. 
  • APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics. 
  • APOE2 is associated with longevity independent of Alzheimer's disease. 
  • APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt Pathway via the phosphoinositol phosphatase SHIP2. 
  • APOE4-mediated amyloid-β pathology depends on its neuronal receptor LRP1. 
  • APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy. 
  • APOL1-G0 or APOL1-G2 Transgenic Models Develop Preeclampsia but Not Kidney Disease. 
  • APOL1-G0 protects podocytes in a mouse model of HIV-associated nephropathy. 
  • ARHGEF26 enhances Salmonella invasion and inflammation in cells and mice. 
  • ASCL1 represses a SOX9+ neural crest stem-like state in small cell lung cancer. 
  • ASH1L Links Histone H3 Lysine 36 Dimethylation to MLL Leukemia. 
  • ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins. 
  • AT1 receptors in the collecting duct directly modulate the concentration of urine. 
  • AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. 
  • AT2 receptor and vascular smooth muscle cell differentiation in vascular development. 
  • ATM Paradoxically Promotes Oncogenic Transformation via Transcriptional Reprogramming. 
  • ATM binds to beta-adaptin in cytoplasmic vesicles. 
  • ATM deficiency promotes progression of CRPC by enhancing Warburg effect. 
  • ATM inhibition enhances cancer immunotherapy by promoting mtDNA leakage and cGAS/STING activation. 
  • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. 
  • ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. 
  • ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. 
  • ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation. 
  • ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. 
  • ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. 
  • Abelson virus abrogation of interleukin-3 dependence in a lymphoid cell line. 
  • Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells. 
  • Aberrant cortical development is driven by impaired cell cycle and translational control in a DDX3X syndrome model. 
  • Aberrant methylation and loss of CADM2 tumor suppressor expression is associated with human renal cell carcinoma tumor progression. 
  • Aberrant responses in social interaction of dopamine transporter knockout mice. 
  • Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation. 
  • Abi3bp is a multifunctional autocrine/paracrine factor that regulates mesenchymal stem cell biology. 
  • Abl Kinases Regulate HGF/Met Signaling Required for Epithelial Cell Scattering, Tubulogenesis and Motility. 
  • Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1. 
  • Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages. 
  • Abl family kinases regulate endothelial barrier function in vitro and in mice. 
  • Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels. 
  • Abl kinases are required for invadopodia formation and chemokine-induced invasion. 
  • Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway. 
  • Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components. 
  • Abl tyrosine kinases are required for infection by Shigella flexneri. 
  • Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases. 
  • Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. 
  • Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload. 
  • Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo. 
  • Ablation of calcineurin Aβ reveals hyperlipidemia and signaling cross-talks with phosphodiesterases. 
  • Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling. 
  • Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy. 
  • Ablation of the leptin receptor in myeloid cells impairs pulmonary clearance of Streptococcus pneumoniae and alveolar macrophage bactericidal function. 
  • Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. 
  • Abnormal cardiac Na(+) channel properties and QT heart rate adaptation in neonatal ankyrin(B) knockout mice. 
  • Abnormal cerebellar signaling induces dystonia in mice. 
  • Abnormal iron deposition in renal cells in the rat with chronic angiotensin II administration. 
  • Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis. 
  • Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. 
  • Abnormal muscle spindle innervation and large-fiber neuropathy in diabetic mice. 
  • Abnormal osmotic regulation in trpv4-/- mice. 
  • Abnormal parathyroid function in the X-linked hypophosphatemic mouse. 
  • Abnormal parathyroid hormone stimulation of 25-hydroxyvitamin D-1 alpha-hydroxylase activity in the hypophosphatemic mouse. Evidence for a generalized defect of vitamin D metabolism. 
  • Abnormal production of interleukin-1 by microglia from trisomy 16 mice. 
  • Abnormal regulation of renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity in the X-linked hypophosphatemic mouse. 
  • Abnormal water metabolism in mice lacking the type 1A receptor for ANG II. 
  • Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses. 
  • Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. 
  • Absence of donor MHC antigen expression ameliorates chronic kidney allograft rejection. 
  • Absence of interferon-gamma-inducible gene IGTP does not significantly alter the development of chagasic cardiomyopathy in mice infected with Trypanosoma cruzi (Brazil strain). 
  • Absence of macrophage involvement in the passive serum therapy of Friend leukemia virus-induced disease. 
  • Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse. 
  • Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin. 
  • Absence of synaptic regulation by phosducin in retinal slices. 
  • Absence of teratogenic effects of progesterone on the developing genital tract of the human female fetus. 
  • Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. 
  • Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse. 
  • Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. 
  • Absence of tubuloglomerular feedback responses in AT1A receptor-deficient mice. 
  • Abundant androgen regulated mRNAs in mouse submandibular gland: cell-free translation of renin precursor mRNA. 
  • Abundant expression of ponsin, a focal adhesion protein, in lens and downregulation of its expression by impaired cytoskeletal signaling. 
  • Accelerated induction of experimental allergic encephalomyelitis in PL/J mice by a non-V beta 8-specific superantigen. 
  • Accelerated neural differentiation of mouse embryonic stem cells on aligned GYIGSR-functionalized nanofibers. 
  • Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. 
  • Accelerated wound healing by injectable star poly(ethylene glycol)-b-poly(propylene sulfide) scaffolds loaded with poorly water-soluble drugs. 
  • Accelerating quantitative susceptibility imaging acquisition using compressed sensing. 
  • Acceleration of mammary neoplasia in transforming growth factor alpha transgenic mice by 7,12-dimethylbenzanthracene. 
  • Accessory subunit KChIP2 modulates the cardiac L-type calcium current. 
  • Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity. 
  • Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease. 
  • Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans. 
  • Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease. 
  • Accurate in vivo tumor detection using plasmonic-enhanced shifted-excitation Raman difference spectroscopy (SERDS). 
  • Accurate temperature imaging based on intermolecular coherences in magnetic resonance. 
  • Acetalated Dextran Microparticles for Codelivery of STING and TLR7/8 Agonists. 
  • Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. 
  • Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals. 
  • Acetylcholine Modulates Cerebellar Granule Cell Spiking by Regulating the Balance of Synaptic Excitation and Inhibition. 
  • Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells. 
  • Acetylcholinesterase Inhibitors Are Associated with Reduced Fracture Risk among Older Veterans with Dementia. 
  • Acetylenics. 2. Synthesis and pharmacology of certain N,N-diakyl-3-phenylpropyn-2-amines. Some analogues with tryptamine-like behavioral effects in mice. 
  • Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. 
  • Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors. 
  • Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF. 
  • Acrylic fragmentation in total hip replacements and its biological consequences. 
  • Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds. 
  • Actin cytoskeletal disruption following cryopreservation alters the biodistribution of human mesenchymal stromal cells in vivo. 
  • Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. 
  • Action potential-coupled Rho GTPase signaling drives presynaptic plasticity. 
  • Actions of thrombin in the interstitium. 
  • Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. 
  • Activated B cells modified by electroporation of multiple mRNAs encoding immune stimulatory molecules are comparable to mature dendritic cells in inducing in vitro antigen-specific T-cell responses. 
  • Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway. 
  • Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death. 
  • Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. 
  • Activating an adaptive immune response from a hydrogel scaffold imparts regenerative wound healing. 
  • Activation and repression of mammalian gene expression by the c-myc protein. 
  • Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene. 
  • Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy. 
  • Activation of GPR37 in macrophages confers protection against infection-induced sepsis and pain-like behaviour in mice. 
  • Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury. 
  • Activation of Glutamatergic Fibers in the Anterior NAc Shell Modulates Reward Activity in the aNAcSh, the Lateral Hypothalamus, and Medial Prefrontal Cortex and Transiently Stops Feeding. 
  • Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. 
  • Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells. 
  • Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. 
  • Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation. 
  • Activation of RalA is critical for Ras-induced tumorigenesis of human cells. 
  • Activation of Rod Input in a Model of Retinal Degeneration Reverses Retinal Remodeling and Induces Formation of Functional Synapses and Recovery of Visual Signaling in the Adult Retina. 
  • Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains. 
  • Activation of a nerve injury transcriptional signature in airway-innervating sensory neurons after lipopolysaccharide-induced lung inflammation. 
  • Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation. 
  • Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis. 
  • Activation of cyclophosphamide for in vitro testing of cell sensitivity. 
  • Activation of decidual invariant natural killer T cells promotes lipopolysaccharide-induced preterm birth. 
  • Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5. 
  • Activation of glycolysis and apoptosis in glycogen storage disease type Ia. 
  • Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation. 
  • Activation of interleukin 4- and interleukin 6-secreting cells by HIV-specific synthetic peptides. 
  • Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence. 
  • Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells. 
  • Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis. 
  • Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. 
  • Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. 
  • Activation of specific interneurons improves V1 feature selectivity and visual perception. 
  • Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production. 
  • Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome. 
  • Activation of the NLRP3 inflammasome by intracellular poly I:C. 
  • Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer. 
  • Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. 
  • Activation of the XBP1s/O-GlcNAcylation Pathway Improves Functional Outcome After Cardiac Arrest and Resuscitation in Young and Aged Mice. 
  • Activation of the mTOR Pathway by Oxaliplatin in the Treatment of Colorectal Cancer Liver Metastasis. 
  • Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation. 
  • Activation of toll-like receptor 4 is necessary for trauma hemorrhagic shock-induced gut injury and polymorphonuclear neutrophil priming. 
  • Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin. 
  • Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome. 
  • Activation-induced cytidine deaminase mediates central tolerance in B cells. 
  • Activation-induced endocytosis of the raft-associated transmembrane adaptor protein LAB/NTAL in B lymphocytes: evidence for a role in internalization of the B cell receptor. 
  • Active immunization using dendritic cells mixed with tumor cells inhibits the growth of primary breast cancer. 
  • Active immunization with tumor cells transduced by a novel AAV plasmid-based gene delivery system. 
  • Active immunotherapy of pancreatic cancer with tumor cells genetically engineered to secrete multiple cytokines. 
  • Active immunotherapy with transiently transfected cytokine-secreting tumor cells inhibits breast cancer metastases in tumor-bearing animals. 
  • Active learning of cortical connectivity from two-photon imaging data. 
  • Active staining of mouse embryos for magnetic resonance microscopy. 
  • Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response. 
  • Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117. 
  • Activity and stability of recombinant bifunctional rearranged and monofunctional domains of ATP-sulfurylase and adenosine 5'-phosphosulfate kinase. 
  • Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice. 
  • Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts. 
  • Activity of VNP40101M (Cloretazine) in the treatment of CNS tumor xenografts in athymic mice. 
  • Activity of a Py-Im polyamide targeted to the estrogen response element. 
  • Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models. 
  • Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice. 
  • Activity of temozolomide in the treatment of central nervous system tumor xenografts. 
  • Activity-dependent PSA expression regulates inhibitory maturation and onset of critical period plasticity. 
  • Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain. 
  • Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons. 
  • Activity-induced remodeling of olfactory bulb microcircuits revealed by monosynaptic tracing. 
  • Acupuncture Resolves Persistent Pain and Neuroinflammation in a Mouse Model of Chronic Overlapping Pain Conditions. 
  • Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma. 
  • Acute N-Acetylcysteine Administration Ameliorates Loss of Olfactory Neurons Following Experimental Injury In Vivo. 
  • Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice. 
  • Acute ethanol administration downregulates human immunodeficiency virus-1 glycoprotein 120-induced KC and RANTES production by murine Kupffer cells and splenocytes. 
  • Acute graft-vs-host disease: pathobiology and management. 
  • Acute in vivo genetic rescue demonstrates that phosphorylation of RIM1alpha serine 413 is not required for mossy fiber long-term potentiation. 
  • Acute inflammatory response via neutrophil activation protects against the development of chronic pain. 
  • Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee. 
  • Acute loss of adipose tissue-derived adiponectin triggers immediate metabolic deterioration in mice. 
  • Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9. 
  • Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice. 
  • Acute murine cytomegalovirus disrupts established transplantation tolerance and causes recipient allo-sensitization. 
  • Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors. 
  • Acute pancreatitis induces FasL gene expression and apoptosis in the liver. 
  • Acute post-injury blockade of α2δ-1 calcium channel subunits prevents pathological autonomic plasticity after spinal cord injury. 
  • Acute respiratory infection with mouse adenovirus type 1. 
  • Acute restraint stress redirects prefrontal cortex circuit function through mGlu₅ receptor plasticity on somatostatin-expressing interneurons. 
  • Acute suppression of insulin resistance-associated hepatic miR-29 in vivo improves glycemic control in adult mice. 
  • Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway. 
  • Acute tubular necrosis. An experimental model detailing the biochemical events accompanying renal injury and recovery. 
  • Acyl derivatives of demethylpenclomedine, an antitumor-active, non-neurotoxic metabolites of penclomedine. 
  • Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration. 
  • Ad-IRF-1 induces apoptosis in esophageal adenocarcinoma. 
  • Adam10 is essential for early embryonic cardiovascular development. 
  • Adaptation after small bowel resection is attenuated by sialoadenectomy: the role for endogenous epidermal growth factor. 
  • Adaptation in a mouse colony monoassociated with Escherichia coli K-12 for more than 1,000 days. 
  • Adaptation of an ICAM-1-tropic enterovirus to the mouse respiratory tract. 
  • Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism. 
  • Adaptive evolution drives the diversification of zinc-finger binding domains. 
  • Adaptive mechanisms that preserve cardiac function in mice without myoglobin. 
  • Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints. 
  • Addition of a second, different allogeneic graft accelerates white cell and platelet engraftment after T-cell-depleted bone marrow transplantation. 
  • Additive and synergistic interactions of monoclonal antibodies and immunotoxins reactive with breast and ovarian cancer. 
  • Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. 
  • Addressing cell-sourcing limitations with gene therapy. 
  • Adeno-Associated Virus-Mediated Gene Therapy in the Mashlool, Atp1a3Mashl/+, Mouse Model of Alternating Hemiplegia of Childhood. 
  • Adeno-associated viral vectors based on serotype 3b use components of the fibroblast growth factor receptor signaling complex for efficient transduction. 
  • Adeno-associated virus serotypes: vector toolkit for human gene therapy. 
  • Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry. 
  • Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model. 
  • Adeno-associated virus-mediated antiangiogenic gene therapy with thrombospondin-1 type 1 repeats and endostatin. 
  • Adenomas induced by polycyclic aromatic hydrocarbons in strain A/J mouse lung correlate with time-integrated DNA adduct levels. 
  • Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death. 
  • Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone. 
  • Adenoviral infection induces a multi-faceted innate cellular immune response that is mediated by the toll-like receptor pathway in A549 cells. 
  • Adenovirus F protein as a delivery vehicle for botulinum B. 
  • Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo. 
  • Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo. 
  • Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications. 
  • Adenovirus-mediated antisense urokinase-type plasminogen activator receptor gene transfer reduces tumor cell invasion and metastasis in non-small cell lung cancer cell lines. 
  • Adenovirus-mediated transfer of CCAAT/enhancer-binding protein-alpha identifies a dominant antiproliferative role for this isoform in hepatocytes. 
  • Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry. 
  • Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis. 
  • Adhesion GPCR Latrophilin 3 regulates synaptic function of cone photoreceptors in a trans-synaptic manner. 
  • Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy. 
  • Adipocyte Xbp1s overexpression drives uridine production and reduces obesity. 
  • Adipogenic and lipolytic effects of chronic glucocorticoid exposure. 
  • Adiponectin is essential for lipid homeostasis and survival under insulin deficiency and promotes β-cell regeneration. 
  • Adiponectin preserves metabolic fitness during aging. 
  • Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. 
  • Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. 
  • Adipose tissue hyaluronan production improves systemic glucose homeostasis and primes adipocytes for CL 316,243-stimulated lipolysis. 
  • Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. 
  • Adjunctive β2-agonist treatment reduces glycogen independently of receptor-mediated acid α-glucosidase uptake in the limb muscles of mice with Pompe disease. 
  • Adjunctive β2-agonists reverse neuromuscular involvement in murine Pompe disease. 
  • Adjuvanticity and protective immunity of Plasmodium yoelii nigeriensis blood-stage soluble antigens encapsulated in fusogenic liposome. 
  • Administration of a CD31-derived peptide delays the onset and significantly increases survival from lethal graft-versus-host disease. 
  • Adoptive transfer of cytotoxic T lymphocytes for the treatment of transplant-associated lymphoma. 
  • Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer. 
  • Adrb2 controls glucose homeostasis by developmental regulation of pancreatic islet vasculature. 
  • Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer. 
  • Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth. 
  • Adrenoceptors, uncoupling proteins, and energy expenditure. 
  • Adult Lung Spheroid Cells Contain Progenitor Cells and Mediate Regeneration in Rodents With Bleomycin-Induced Pulmonary Fibrosis. 
  • Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment. 
  • Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis. 
  • Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models. 
  • Advantages of mRNA amplification for microarray analysis. 
  • Adynamic Bone Decreases Bone Toughness During Aging by Affecting Mineral and Matrix. 
  • Aerobic exercise attenuates airway inflammatory responses in a mouse model of atopic asthma. 
  • Aerobic training as an adjunctive therapy to enzyme replacement in Pompe disease. 
  • Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas. 
  • Affinity-matured recombinant immunotoxin targeting gangliosides 3'-isoLM1 and 3',6'-isoLD1 on malignant gliomas. 
  • Agathisflavone isolated from Anacardium occidentale suppresses SIRT1-mediated neuroinflammation in BV2 microglia and neurotoxicity in APPSwe-transfected SH-SY5Y cells. 
  • Age Correlates with Response to Anti-PD1, Reflecting Age-Related Differences in Intratumoral Effector and Regulatory T-Cell Populations. 
  • Age as an independent risk factor for severity of experimental choroidal neovascularization. 
  • Age-Dependent Effects of Immunoproteasome Deficiency on Mouse Adenovirus Type 1 Pathogenesis. 
  • Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis. 
  • Age-associated insolubility of parkin in human midbrain is linked to redox balance and sequestration of reactive dopamine metabolites. 
  • Age-dependent alterations of peritoneal exudate macrophages in autoimmune-prone and autoimmune-resistant mouse strains. 
  • Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. 
  • Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice. 
  • Age-related changes in eye morphology and aqueous humor dynamics in DBA/2J mice using contrast-enhanced ocular MRI. 
  • Age-related changes in the cellular composition and epithelial organization of the mouse trachea. 
  • Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration. 
  • Age-related efficacy with an AAV vector in Fabry disease mice. 
  • Ager-CreERT2: A New Genetic Tool for Studying Lung Alveolar Development, Homeostasis, and Repair. 
  • Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells. 
  • Aggressive fibromatosis (desmoid tumor) is derived from mesenchymal progenitor cells. 
  • Aging Is Associated With Impaired Activation of Protein Homeostasis-Related Pathways After Cardiac Arrest in Mice. 
  • Aging and neoplasia. 
  • Aging and reactivation of latent murine cytomegalovirus. 
  • Aging enhances the basal production of IL-6 and CCL2 in vascular smooth muscle cells. 
  • Aging reduces liver resiliency by dysregulating Hedgehog signaling. 
  • Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies. 
  • Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C. 
  • Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration. 
  • Agonist-specific regulation of delta-opioid receptor trafficking by G protein-coupled receptor kinase and beta-arrestin. 
  • Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. 
  • Agonists of G-Protein-Coupled Odorant Receptors Are Predicted from Chemical Features. 
  • Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury. 
  • Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. 
  • Airway smooth muscle dysfunction in Pompe (Gaa-/- ) mice. 
  • Airway smooth muscle relaxation is impaired in mice lacking the p47phox subunit of NAD(P)H oxidase. 
  • Airway-specific inducible transgene expression using aerosolized doxycycline. 
  • Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. 
  • Akt is required for Stat5 activation and mammary differentiation. 
  • Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. 
  • Akt-dependent and -independent mechanisms of mTOR regulation in cancer. 
  • Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. 
  • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. 
  • Akt/protein kinase B promotes organ growth in transgenic mice. 
  • Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. 
  • Akt1 and Akt2 promote peripheral B-cell maturation and survival. 
  • Akt1 deletion prevents lung tumorigenesis by mutant K-ras. 
  • Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring. 
  • Aldolase B-Mediated Fructose Metabolism Drives Metabolic Reprogramming of Colon Cancer Liver Metastasis. 
  • Aldosterone Exposure Causes Increased Retinal Edema and Severe Retinopathy Following Laser-Induced Retinal Vein Occlusion in Mice. 
  • Aldosterone, ion channels, and sudden death: another piece of the circle? 
  • Aldosterone-Induced Vascular Remodeling and Endothelial Dysfunction Require Functional Angiotensin Type 1a Receptors. 
  • Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors. 
  • Alginate encapsulation is a highly reproducible method for tumor cell implantation in dorsal skinfold chambers. 
  • Aligning animal models with clinical epilepsy: where to begin? 
  • Allele separation facilitates interpretation of potential splicing alterations and genomic rearrangements. 
  • Allele-specific regulation of TCR beta variable gene segment chromatin structure. 
  • Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome. 
  • Allelic exclusion of mouse T cell receptor alpha chains occurs at the time of thymocyte TCR up-regulation. 
  • Allelic exclusion of the T cell receptor alpha-chain: developmental regulation of a post-translational event. 
  • Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl. 
  • Allergen-induced airway disease is mouse strain dependent. 
  • Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse. 
  • Allergic lung responses are increased in prostaglandin H synthase-deficient mice. 
  • Allo-Specific Humoral Responses: New Methods for Screening Donor-Specific Antibody and Characterization of HLA-Specific Memory B Cells. 
  • Allocation of epiblast cells to germ layer derivatives during mouse gastrulation as studied with a retroviral vector. 
  • Allogeneic Stem-Cell Transplantation - A T-Cell Balancing ACT. 
  • Allogeneic memory T cell response. 
  • Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease. 
  • Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide. 
  • Allometric scaling of decompression sickness risk in terrestrial mammals; cardiac output explains risk of decompression sickness. 
  • Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice. 
  • Allosteric inhibitor of β-catenin selectively targets oncogenic Wnt signaling in colon cancer. 
  • Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency. 
  • Alpha 2 macroglobulin-proteinase complexes stimulate prostaglandin E2 synthesis by peritoneal macrophages. 
  • Alpha 2-macroglobulin 'fast' forms inhibit superoxide production by activated macrophages. 
  • Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism. 
  • Alpha-chemokine receptor blockade reduces high mobility group box 1 protein-induced lung inflammation and injury and improves survival in sepsis. 
  • Alpha-fetoprotein-specific genetic immunotherapy for hepatocellular carcinoma. 
  • Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon. 
  • Alphavirus Replicon Particle Vaccine Breaks B Cell Tolerance and Rapidly Induces IgG to Murine Hematolymphoid Tumor Associated Antigens. 
  • Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen. 
  • Alphavirus replicon particles as candidate HIV vaccines. 
  • Alprazolam reduces stress hyperglycemia in ob/ob mice. 
  • Alterations in PKCgamma in the mouse hippocampus after prenatal exposure to heroin: a link from cell signaling to behavioral outcome. 
  • Alterations in calcium channel currents underlie defective insulin secretion in a transgenic mouse. 
  • Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone. 
  • Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. 
  • Alterations in inorganic phosphate in mouse hindlimb muscles during limb disuse. 
  • Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance. 
  • Alterations in slow-twitch muscle phenotype in transgenic mice overexpressing the Ca2+ buffering protein parvalbumin. 
  • Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis. 
  • Altered Mitochondrial Homeostasis during Systemic Lupus Erythematosus Impairs Neutrophil Extracellular Trap Formation Rendering Neutrophils Ineffective at Combating Staphylococcus aureus. 
  • Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes. 
  • Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. 
  • Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. 
  • Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. 
  • Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant. 
  • Altered cell-averaged microviscosity of murine peritoneal macrophages undergoing activation in vivo or in vitro. 
  • Altered clearance of human alpha 2-macroglobulin complexes following reaction with cis-dichlorodiamineplatinum(II). 
  • Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients. 
  • Altered distribution of mitochondria and actin fibers in 3T3 cells cultured on microcarriers. 
  • Altered expression of ganglioside phenotypes of human gliomas in vivo and in vitro. 
  • Altered growth of a human neuroendocrine carcinoma line after transfection of a major histocompatibility complex class I gene. 
  • Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage. 
  • Altered immune responses in apolipoprotein E-deficient mice. 
  • Altered inflammatory responses in leukotriene-deficient mice. 
  • Altered interaction of Cis-dichlorodiammineplatinum(II)--modified alpha 2-macroglobulin (alpha 2M) with the low density lipoprotein receptor-related protein/alpha 2M receptor but not the alpha 2M signaling receptor. 
  • Altered intragraft immune responses and improved renal function in MHC class II-deficient mouse kidney allografts. 
  • Altered localization of choline transporter sites in the mouse hippocampus after prenatal heroin exposure. 
  • Altered lymphopoiesis and immunodeficiency in miR-142 null mice. 
  • Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. 
  • Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB. 
  • Altered regulation of brain-derived neurotrophic factor protein in hippocampus following slice preparation. 
  • Altered stored calcium release in skeletal myotubes deficient of triadin and junctin. 
  • Altered synthesis of the 26-kDa heat stress protein family and thermotolerance in cell lines with elevated levels of calcium-binding proteins. 
  • Altered toll-like receptor responsiveness underlies a dominant heritable defect in B cell tolerance in autoimmune New Zealand Black mice. 
  • Altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen VI null mice. 
  • Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. 
  • Altered wound healing in mice lacking a functional osteopontin gene (spp1). 
  • Altering and assessing persistence of genetically modified E. coli MG1655 in the large bowel. 
  • Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer. 
  • Alternative Splicing of Opioid Receptor Genes Shows a Conserved Pattern for 6TM Receptor Variants. 
  • Alternative pathways for the selection of antigen-specific peripheral T cells. 
  • Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by trans splicing. 
  • Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice. 
  • Alternative splicing of an insect sodium channel gene generates pharmacologically distinct sodium channels. 
  • Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer. 
  • Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer. 
  • Alternative splicing: a mechanism for phenotypic rescue of a common inherited defect. 
  • Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism. 
  • Alveolar Epithelial Cell-Derived Prostaglandin E2 Serves as a Request Signal for Macrophage Secretion of Suppressor of Cytokine Signaling 3 during Innate Inflammation. 
  • Alveolar macrophage apoptosis and TNF-alpha, but not p53, expression correlate with murine response to bleomycin. 
  • Alveolar proteinosis: a disease of mice and men. 
  • Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression. 
  • Alveolar septal structure in different species. 
  • Alzheimer's Risk Factors Age, APOE Genotype, and Sex Drive Distinct Molecular Pathways. 
  • Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. 
  • Amenable epigenetic traits of dental pulp stem cells underlie high capability of xeno-free episomal reprogramming. 
  • Amino acid-based Poly(ester urea) copolymer films for hernia-repair applications. 
  • Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor. 
  • Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin. 
  • Amitriptyline Treatment Mitigates Sepsis-Induced Tumor Necrosis Factor Expression and Coagulopathy. 
  • Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts. 
  • Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin. 
  • Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. 
  • Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice. 
  • Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells. 
  • Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. 
  • Amyloid-beta1-42 reduces neuronal excitability in mouse dentate gyrus. 
  • An AOTF-based dual-modality hyperspectral imaging system (DMHSI) capable of simultaneous fluorescence and reflectance imaging. 
  • An ARF-independent c-MYC-activated tumor suppression pathway mediated by ribosomal protein-Mdm2 Interaction. 
  • An Adeno-Associated Virus-Based Toolkit for Preferential Targeting and Manipulating Quiescent Neural Stem Cells in the Adult Hippocampus. 
  • An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. 
  • An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments. 
  • An Efficient Method for Labeling Single Domain Antibody Fragments with 18F Using Tetrazine- Trans-Cyclooctene Ligation and a Renal Brush Border Enzyme-Cleavable Linker. 
  • An Engineered Biomimetic MPER Peptide Vaccine Induces Weakly HIV Neutralizing Antibodies in Mice. 
  • An Engineered Metal Sensor Tunes the Kinetics of Synaptic Transmission. 
  • An Engineered Optogenetic Switch for Spatiotemporal Control of Gene Expression, Cell Differentiation, and Tissue Morphogenesis. 
  • An Evolutionary Insertion in the Mxra8 Receptor-Binding Site Confers Resistance to Alphavirus Infection and Pathogenesis. 
  • An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. 
  • An FGF-WNT gene regulatory network controls lung mesenchyme development. 
  • An HIV-1 vaccine based on bacterium-like particles elicits Env-specific mucosal immune responses. 
  • An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis. 
  • An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. 
  • An Immunogenic and Slow-Growing Cryptococcal Strain Induces a Chronic Granulomatous Infection in Murine Lungs. 
  • An Improved 211At-Labeled Agent for PSMA-Targeted α-Therapy. 
  • An In Vivo Model of Echovirus-Induced Meningitis Defines the Differential Roles of Type I and Type III Interferon Signaling in Central Nervous System Infection. 
  • An In Vivo Screen Identifies PYGO2 as a Driver for Metastatic Prostate Cancer. 
  • An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation. 
  • An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15. 
  • An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice. 
  • An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. 
  • An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria. 
  • An acquired channelopathy involving thalamic T-type Ca2+ channels after status epilepticus. 
  • An activated factor VII variant with enhanced tissue factor-independent activity speeds wound healing in a mouse hemophilia B model. 
  • An adenoviral vaccine encoding full-length inactivated human Her2 exhibits potent immunogenicty and enhanced therapeutic efficacy without oncogenicity. 
  • An alanine residue in the M3-M4 linker lines the glycine binding pocket of the N-methyl-D-aspartate receptor. 
  • An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells. 
  • An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus. 
  • An analysis of the uncertainty and bias in DCE-MRI measurements using the spoiled gradient-recalled echo pulse sequence. 
  • An animal model of MYC-driven medulloblastoma. 
  • An anionic, endosome-escaping polymer to potentiate intracellular delivery of cationic peptides, biomacromolecules, and nanoparticles. 
  • An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan. 
  • An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. 
  • An anxiety-like phenotype in mice selectively bred for aggression. 
  • An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage. 
  • An apolipoprotein E-based therapeutic improves outcome and reduces Alzheimer's disease pathology following closed head injury: evidence of pharmacogenomic interaction. 
  • An apolipoprotein E-mimetic stimulates axonal regeneration and remyelination after peripheral nerve injury. 
  • An array of 60,000 antibodies for proteome-scale antibody generation and target discovery. 
  • An artery-specific fluorescent dye for studying neurovascular coupling. 
  • An assessment of the effects of shell cross-linked nanoparticle size, core composition, and surface PEGylation on in vivo biodistribution. 
  • An automated decision-tree approach to predicting protein interaction hot spots. 
  • An ear punch model for studying the effect of radiation on wound healing. 
  • An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants. 
  • An efficient multiple-exposure analysis of the toxicity of crisnatol, a DNA intercalator in phase II clinical trials. 
  • An encyclopedia of mouse DNA elements (Mouse ENCODE). 
  • An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models. 
  • An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. 
  • An endothelial TLR4-VEGFR2 pathway mediates lung protection against oxidant-induced injury. 
  • An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia. 
  • An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy. 
  • An entirely cell-based system to generate single-chain antibodies against cell surface receptors. 
  • An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. 
  • An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. 
  • An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. 
  • An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production. 
  • An essential role for c-FLIP in the efficient development of mature T lymphocytes. 
  • An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. 
  • An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. 
  • An essential role of Bmp4 in the atrioventricular septation of the mouse heart. 
  • An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina. 
  • An imaging-based approach to identify ligands for olfactory receptors. 
  • An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. 
  • An in vitro assay procedure to test chemotherapeutic drugs on cells from human solid tumors. 
  • An in vivo model to quantify motor and sensory peripheral nerve regeneration using bioresorbable nerve guide tubes. 
  • An in vivo platform for translational drug development in pancreatic cancer. 
  • An increase in the myocardial PCr/ATP ratio in GLUT4 null mice. 
  • An inhibitor of macrophage chemotaxis produced by neoplasms. 
  • An inhibitor of nuclear scaffold protease blocks chemical transformation of fibroblasts. 
  • An injectable method for noninvasive spine fusion. 
  • An integrated widefield imaging and spectroscopy system for contrast-enhanced, image-guided resection of tumors. 
  • An integrative model of mouse cardiac electrophysiology from cell to torso. 
  • An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. 
  • An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface. 
  • An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells. 
  • An intravital window to image the colon in real time. 
  • An intrinsic oscillator drives the blood stage cycle of the malaria parasite Plasmodium falciparum. 
  • An intron facilitates activation of the calspermin gene by the testis-specific transcription factor CREM tau. 
  • An investigation of hemopexin redox properties by spectroelectrochemistry: biological relevance for heme uptake. 
  • An investigation of kV mini-GRID spatially fractionated radiation therapy: dosimetry and preclinical trial. 
  • An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. 
  • An oncogenic Ezh2 mutation induces tumors through global redistribution of histone 3 lysine 27 trimethylation. 
  • An opposite role for tau in circadian rhythms revealed by mathematical modeling. 
  • An overview of lung cancer genomics and proteomics. 
  • An oxidized extracellular oxidation-reduction state increases Nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor activation. 
  • An ultra-sensitive method to detect mutations in human RAS templates. 
  • An ultrastructural study of C-type virion assembly in mouse cells. 
  • An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection. 
  • Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts. 
  • Anabolic function of the type II isozyme of hexokinase in hepatic lipid synthesis. 
  • Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal. 
  • Analyses of Calcium-Independent Phospholipase A2beta (iPLA2β) in Biological Systems. 
  • Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2. 
  • Analysis of Brain Protein Stability Changes in Mouse Models of Normal Aging and α-Synucleinopathy Reveals Age- and Disease-Related Differences. 
  • Analysis of DNA damage and repair in nuclear and mitochondrial DNA of animal cells using quantitative PCR. 
  • Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations. 
  • Analysis of T-cell differentiation antigens in acute lymphatic leukemia using monoclonal antibodies. 
  • Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells. 
  • Analysis of a food-borne fungal pathogen outbreak: virulence and genome of a Mucor circinelloides isolate from yogurt. 
  • Analysis of corneal and conjunctival microenvironments using monoclonal antibodies. 
  • Analysis of expression of multiple genes encoding calmodulin during spermatogenesis. 
  • Analysis of gene mutations and clastogenicity following short-term treatment with azathioprine in MutaMouse. 
  • Analysis of left ventricular hemodynamics in physiological hyperspace. 
  • Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometry. 
  • Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells. 
  • Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestation. 
  • Analysis of multi-arm tumor growth trials in xenograft animals using phase change adaptive piecewise quadratic models. 
  • Analysis of muscle creatine kinase regulatory elements in recombinant adenoviral vectors. 
  • Analysis of neurogenesis in a mammalian neuroepithelium: proliferation and differentiation of an olfactory neuron precursor in vitro. 
  • Analysis of neuronal proliferation, migration and differentiation in the postnatal brain using equine infectious anemia virus-based lentiviral vectors. 
  • Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. 
  • Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. 
  • Analysis of recombinant Phex: an endopeptidase in search of a substrate. 
  • Analysis of regulatory CD8 T cells in Qa-1-deficient mice. 
  • Analysis of repetitive sequence elements containing tRNA-like sequences. 
  • Analysis of the Conditions That Affect the Selective Processing of Endogenous Notch1 by ADAM10 and ADAM17. 
  • Analysis of the E399D mutation in SLC11A2. 
  • Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment. 
  • Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases. 
  • Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes. 
  • Analysis of the globose basal cell compartment in rat olfactory epithelium using GBC-1, a new monoclonal antibody against globose basal cells. 
  • Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire. 
  • Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. 
  • Analysis of the mouse transcriptome for genes involved in the function of the nervous system. 
  • Analysis of the relationship between stage of differentiation and NK/LAK susceptibility of colon carcinoma cells. 
  • Analysis of the role of E2A-encoded proteins in insulin gene transcription. 
  • Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice. 
  • Analysis of the stimulatory effect of splicing on mRNA production and utilization in mammalian cells. 
  • Analysis of transcriptome complexity through RNA sequencing in normal and failing murine hearts. 
  • Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene. 
  • Anaplastic human gliomas grown in athymic mice. Morphology and glial fibrillary acidic protein expression. 
  • Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent. 
  • Anatomy and spatial organization of Müller glia in mouse retina. 
  • Ancestral and consensus envelope immunogens for HIV-1 subtype C. 
  • Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells 
  • Anchorage-independent cell growth signature identifies tumors with metastatic potential. 
  • Androgen decreases dopamine neurone survival in rat midbrain. 
  • Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers. 
  • Androgen receptor splice variant AR3 promotes prostate cancer via modulating expression of autocrine/paracrine factors. 
  • Androgen receptor with short polyglutamine tract preferably enhances Wnt/β-catenin-mediated prostatic tumorigenesis. 
  • Androgen-independent prostate cancer progression in the TRAMP model. 
  • Androgen-mediated immune function is altered by the apolipoprotein E gene. 
  • Androgenic dependence of exophytic tumor growth in a transgenic mouse model of bladder cancer: a role for thrombospondin-1. 
  • Anemia of inflammation: the cytokine-hepcidin link. 
  • Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice. 
  • Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. 
  • Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury. 
  • Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. 
  • Angiopoietin-1 is required for Schlemm's canal development in mice and humans. 
  • Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide. 
  • Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase. 
  • Angiotensin 1-7 reduces mortality and rupture of intracranial aneurysms in mice. 
  • Angiotensin AT1B receptor mediates calcium signaling in vascular smooth muscle cells of AT1A receptor-deficient mice. 
  • Angiotensin II Short-Loop Feedback: Is There a Role of Ang II for the Regulation of the Renin System In Vivo? 
  • Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin. 
  • Angiotensin II attenuates chemical hypoxia-induced caspase-3 activation in primary cortical neuronal cultures. 
  • Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. 
  • Angiotensin II enhances bacterial clearance via myeloid signaling in a murine sepsis model. 
  • Angiotensin II plays a role in acute murine experimental autoimmune cystitis. 
  • Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. 
  • Angiotensin II promotes development of the renal microcirculation through AT1 receptors. 
  • Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. 
  • Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation. 
  • Angiotensin II stimulates canonical TGF-β signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction. 
  • Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells. 
  • Angiotensin II type 1 receptor-associated protein is an endogenous inhibitor of angiotensin II type 1 receptor action in cardiac hypertrophy: role in check and balance. 
  • Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. 
  • Angiotensin II type 2 receptor mediates programmed cell death. 
  • Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration. 
  • Angiotensin II-induced hypertension regulates AT1 receptor subtypes and extracellular matrix turnover in mouse retinal pigment epithelium. 
  • Angiotensin II: an immune costimulator? 
  • Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme. 
  • Angiotensin induces the urinary peristaltic machinery during the perinatal period. 
  • Angiotensin protects cortical neurons from hypoxic-induced apoptosis via the angiotensin type 2 receptor. 
  • Angiotensin receptor signaling and prostate tumor growth in mice. 
  • Angiotensin receptors in the kidney and vasculature in hypertension and kidney disease. 
  • Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. 
  • Angiotensin-(1-7) Attenuates Skeletal Muscle Fibrosis and Stiffening in a Mouse Model of Extremity Sarcoma Radiation Therapy. 
  • Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages. 
  • Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorption. 
  • Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. 
  • Animal models in the research of abdominal aortic aneurysms development. 
  • Animal models of bleeding and tissue repair. 
  • Animal models of hereditary iron transport disorders. 
  • Animal models of human prostate cancer: the consensus report of the New York meeting of the Mouse Models of Human Cancers Consortium Prostate Pathology Committee. 
  • Animal models of steatohepatitis. 
  • Animal models of steatosis. 
  • Animal models provide insight into psychosomatic factors in diabetes. 
  • Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory. 
  • Ank3-dependent SVZ niche assembly is required for the continued production of new neurons. 
  • Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain. 
  • Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics. 
  • Ankyrin-B interactions with spectrin and dynactin-4 are required for dystrophin-based protection of skeletal muscle from exercise injury. 
  • Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes. 
  • Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors. 
  • Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins. 
  • Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency. 
  • Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. 
  • Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence. 
  • Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. 
  • Ankyrin-G Inhibits Endocytosis of Cadherin Dimers. 
  • Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells. 
  • Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. 
  • Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo. 
  • Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. 
  • Ankyrin-G promotes cyclic nucleotide-gated channel transport to rod photoreceptor sensory cilia. 
  • Ankyrin-G regulates forebrain connectivity and network synchronization via interaction with GABARAP. 
  • Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment. 
  • Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons. 
  • AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. 
  • AnkyrinG is required to maintain axo-dendritic polarity in vivo. 
  • Ankyrins. 
  • Annexin-A1 Tripeptide Attenuates Surgery-Induced Neuroinflammation and Memory Deficits Through Regulation the NLRP3 Inflammasome. 
  • Another cystic mystery solved. 
  • Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1beta. 
  • Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis. 
  • Antagonists of the system L neutral amino acid transporter (LAT) promote endothelial adhesivity of human red blood cells. 
  • Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. 
  • Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents. 
  • Anti-CD22 ligand-blocking antibody HB22.7 has independent lymphomacidal properties and augments the efficacy of 90Y-DOTA-peptide-Lym-1 in lymphoma xenografts. 
  • Anti-CD37 chimeric antigen receptor T cells are active against B- and T-cell lymphomas. 
  • Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis. 
  • Anti-DNA and autoantibodies. 
  • Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites. 
  • Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. 
  • Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands. 
  • Anti-Ebola MAb 17A3 reacts with bovine and human alpha-2-macroglobulin proteins. 
  • Anti-La antibody production by MRL-1pr/1pr mice. Analysis of fine specificity. 
  • Anti-PD-1 treatment impairs opioid antinociception in rodents and nonhuman primates. 
  • Anti-PEG Antibodies Inhibit the Anticoagulant Activity of PEGylated Aptamers. 
  • Anti-Sm autoantibodies in MRL mice: analysis of precursor frequency. 
  • Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA. 
  • Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype. 
  • Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. 
  • Anti-amyloid-beta immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials. 
  • Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators. 
  • Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct. 
  • Anti-bombesin monoclonal antibodies modulate fetal mouse lung growth and maturation in utero and in organ cultures. 
  • Anti-fibrotic activity of a rho-kinase inhibitor restores outflow function and intraocular pressure homeostasis. 
  • Anti-glycoprotein D monoclonal antibody protects against herpes simplex virus type 1-induced diseases in mice functionally depleted of selected T-cell subsets or asialo GM1+ cells. 
  • Anti-idiotypic antibodies as vaccine candidates. The immune network. 
  • Anti-idiotypic monoclonal Ig specific for an anti-laminin Ig heavy chain transgene variable region. 
  • Anti-idiotypic monoclonal antibodies to GM1 identify ganglioside binding proteins. 
  • Anti-inflammatory activity of amine cyanoboranes, amine carboxyboranes, and related compounds. 
  • Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata. 
  • Anti-inflammatory and anti-osteoporotic activities of base-boronated nucleosides and phosphate-boronated nucleotides in rodents. 
  • Anti-inflammatory and vasoprotective activity of a retroviral-derived peptide, homologous to human endogenous retroviruses: endothelial cell effects. 
  • Anti-inflammatory effects of inhibiting the amine oxidase activity of semicarbazide-sensitive amine oxidase. 
  • Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia. 
  • Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis. 
  • Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies. 
  • Anti-mouse mesangial cell serum induces acute glomerulonephropathy in mice. 
  • Anti-receptor antibody-induced H-Y-specific delayed-type hypersensitivity responses in nonresponder mice. 
  • Anti-receptor antibody-induced suppression of murine H-Y-specific delayed-type hypersensitivity responses. 
  • Anti-tubulin drugs conjugated to anti-ErbB antibodies selectively radiosensitize. 
  • Anti-tumor activity of a novel monoclonal antibody, NPC-1C, optimized for recognition of tumor antigen MUC5AC variant in preclinical models. 
  • Anti-tumor immunotherapy despite immunity to adenovirus using a novel adenoviral vector Ad5 [E1-, E2b-]-CEA. 
  • Antiadhesive properties of a quaternary structure-specific hybridoma antibody against type 1 fimbriae of Escherichia coli. 
  • Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor. 
  • Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. 
  • Antiangiogenic treatment with the three thrombospondin-1 type 1 repeats recombinant protein in an orthotopic human pancreatic cancer model. 
  • Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model. 
  • Antiapoptotic Bcl-2 family proteins BCL-xL and MCL-1 integrate neural progenitor survival and proliferation during postnatal cerebellar neurogenesis. 
  • Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut. 
  • Antibodies as specific renin inhibitors: studies with polyclonal and monoclonal antibodies and Fab fragments. 
  • Antibodies to a Conserved Influenza Head Interface Epitope Protect by an IgG Subtype-Dependent Mechanism. 
  • Antibodies to stem cell marker antigens reduce engraftment of hematopoietic stem cells. 
  • Antibody Feedback Limits the Expansion of B Cell Responses to Malaria Vaccination but Drives Diversification of the Humoral Response. 
  • Antibody alone does not prevent experimental cytomegalovirus retinitis in mice with retrovirus-induced immunodeficiency (MAIDS). 
  • Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton. 
  • Antibody formation and mannose-6-phosphate receptor expression impact the efficacy of muscle-specific transgene expression in murine Pompe disease. 
  • Antibody is critical for the clearance of murine norovirus infection. 
  • Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. 
  • Antibody reacting with mouse mammary tumor virus in serum of breast carcinoma patients. 
  • Antibody response to a T-dependent antigen requires B cell expression of complement receptors. 
  • Antibody-dependent cytolysis (ADCC) of tumor cells by activated murine macrophages is a two-step process: quantification of target binding and subsequent target lysis. 
  • Antibody-induced proteinase activation: a proposed mechanism for pemphigus. 
  • Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice. 
  • Antibody-mediated enzyme replacement therapy targeting both lysosomal and cytoplasmic glycogen in Pompe disease. 
  • Antibody-targeted photodynamic therapy. 
  • Anticancer therapeutic potential of Mn porphyrin/ascorbate system. 
  • Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. 
  • Antidote-mediated control of an anticoagulant aptamer in vivo. 
  • Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance. 
  • Antigen delivery by alpha(2)-macroglobulin enhances the cytotoxic T lymphocyte response. 
  • Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers. 
  • Antigen receptor repertoire profiling from RNA-seq data. 
  • Antigen-binding repertoire and Ig H chain gene usage among B cell hybridomas from normal and autoimmune mice. 
  • Antigen-loaded monocyte administration induces potent therapeutic antitumor T cell responses. 
  • Antigen-presenting cells pulsed with unfractionated tumor-derived peptides are potent tumor vaccines. 
  • Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade. 
  • Antigenic comparison of virus strains of mild and classical types of epidemic haemorrhagic fever isolated in China and adaptation of these to cultures of normal cells. 
  • Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoprotein. 
  • Antigens of human pancreatic adenocarcinoma cells defined by murine monoclonal antibodies. 
  • Antigens shared by rat schwannomas, neuroblastomas, and a testicular interstitial cell carcinoma. 
  • Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. 
  • Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds. 
  • Antiidiotypic antibody recognizes an amiloride binding domain within the alpha subunit of the epithelial Na+ channel. 
  • Antiinflammatory proteins associated with human and murine neoplasms. 
  • Antillatoxin, a novel lipopeptide, enhances neurite outgrowth in immature cerebrocortical neurons through activation of voltage-gated sodium channels. 
  • Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms. 
  • Antineoplastic activity of a series of boron analogues of alpha-amino acids. 
  • Antineoplastic activity of boron-containing thymidine nucleosides in Tmolt3 leukemic cells. 
  • Antineoplastic activity of tetrakis-mu-(trimethylamine-boranecarboxylato)-bis (trimethylamine-carboxyborane)dicopper (II) in Ehrlich ascites carcinoma. 
  • Antinuclear antibodies and nuclear antigens in NZB myeloma ascitic fluids. 
  • Antioxidants preserve macrophage phagocytosis of Pseudomonas aeruginosa during hyperoxia. 
  • Antioxidants suppress mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus (SLE). 
  • Antiproliferative effects of cyclocreatine on human prostatic carcinoma cells. 
  • Antiproliferative effects of interferon alpha on hepatic progenitor cells in vitro and in vivo. 
  • Antiseizure effects of TrkB kinase inhibition. 
  • Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates. 
  • Antisense inhibition of group II phospholipase A2 expression blocks the production of prostaglandin E2 by P388D1 cells. 
  • Antisense oligonucleotides targeting mutant Ataxin-7 restore visual function in a mouse model of spinocerebellar ataxia type 7. 
  • Antitenascin antibody 81C6 armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands. 
  • Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas. 
  • Antitumor activity of a monoclonal antibody directed against gastrin-releasing peptide in patients with small cell lung cancer. 
  • Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models. 
  • Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer. 
  • Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma. 
  • Antitumour activity of S-p-bromobenzylglutathione cyclopentyl diester in vitro and in vivo. Inhibition of glyoxalase I and induction of apoptosis. 
  • Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo. 
  • Antiviral activity of human OASL protein is mediated by enhancing signaling of the RIG-I RNA sensor. 
  • Antiviral activity of mixed-valence rare earth borotungstate heteropoly blues against influenza virus in mice. 
  • Anxiety-like behaviors in mice lacking GIT2. 
  • Anxiolytic effects of acute morphine can be modulated by nitric oxide systems. 
  • Apical CLC-2 in retinal pigment epithelium is crucial for survival of the outer retina. 
  • Apo E structure determines VLDL clearance and atherosclerosis risk in mice. 
  • ApoB-48 and apoB-100 differentially influence the expression of type-III hyperlipoproteinemia in APOE*2 mice. 
  • ApoE isoform affects LTP in human targeted replacement mice. 
  • ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42. 
  • ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. 
  • ApoER2 function in the establishment and maintenance of retinal synaptic connectivity. 
  • Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. 
  • Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice. 
  • Apolipoprotein E Mimetic Peptide Increases Cerebral Glucose Uptake by Reducing Blood-Brain Barrier Disruption after Controlled Cortical Impact in Mice: An 18F-Fluorodeoxyglucose PET/CT Study. 
  • Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport. 
  • Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. 
  • Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. 
  • Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. 
  • Apolipoprotein E and mimetic peptide initiate a calcium-dependent signaling response in macrophages. 
  • Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A. 
  • Apolipoprotein E and the CNS response to injury. 
  • Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse. 
  • Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation. 
  • Apolipoprotein E isoform mediated regulation of nitric oxide release. 
  • Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice. 
  • Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain. 
  • Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond. 
  • Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex. 
  • Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway. 
  • Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. 
  • Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice. 
  • Apolipoprotein E suppresses glial cell secretion of TNF alpha. 
  • Apolipoprotein E-Mimetic COG1410 Reduces Acute Vasogenic Edema following Traumatic Brain Injury. 
  • Apolipoprotein E-deficient mice created by systemic administration of antisense oligodeoxynucleotides: a new model for lipoprotein metabolism studies. 
  • Apolipoprotein E-deficient mice have increased susceptibility to focal cerebral ischemia. 
  • Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. 
  • Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner. 
  • Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. 
  • Apolipoprotein E4 exaggerates diabetic dyslipidemia and atherosclerosis in mice lacking the LDL receptor. 
  • Apolipoprotein E4 impairs the response of neurodegenerative retinal microglia and prevents neuronal loss in glaucoma. 
  • Apolipoprotein J/clusterin induction in myocarditis: A localized response gene to myocardial injury. 
  • ApolipoproteinE mimetic peptides improve outcome after focal ischemia. 
  • Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity. 
  • Apoptosis and B cell tolerance. 
  • Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. 
  • Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. 
  • Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus. 
  • Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration. 
  • Apoptotic sphingolipid signaling by ceramides in lung endothelial cells. 
  • Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation. 
  • Application of a Novel Murine Ear Vein Model to Evaluate the Effects of a Vascular Radioprotectant on Radiation-Induced Vascular Permeability and Leukocyte Adhesion. 
  • Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90. 
  • Application of combined omics platforms to accelerate biomedical discovery in diabesity. 
  • Application of proteomic marker ensembles to subcellular organelle identification. 
  • Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma. 
  • Applications for green fluorescent protein (GFP) in the study of host-pathogen interactions. 
  • Applications of gene fusions to green fluorescent protein and flow cytometry to the study of bacterial gene expression in host cells. 
  • Approximating transcranial magnetic stimulation with electric stimulation in mouse: a simulation study. 
  • Aptamers selected against the unglycosylated EGFRvIII ectodomain and delivered intracellularly reduce membrane-bound EGFRvIII and induce apoptosis. 
  • Aquaporin 6 binds calmodulin in a calcium-dependent manner. 
  • Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulence. 
  • Aquaporin in Candida: characterization of a functional water channel protein. 
  • Arachidonic acid mobilization in P388D1 macrophages is controlled by two distinct Ca(2+)-dependent phospholipase A2 enzymes. 
  • Architectural Modification of Conformal PEG-Bottlebrush Coatings Minimizes Anti-PEG Antigenicity While Preserving Stealth Properties. 
  • Are there effective new strategies for the treatment of acute and chronic GvHD? 
  • Arfgef1 haploinsufficiency in mice alters neuronal endosome composition and decreases membrane surface postsynaptic GABAA receptors. 
  • Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. 
  • Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. 
  • Argon Inhalation for 24 h After Closed-Head Injury Does not Improve Recovery, Neuroinflammation, or Neurologic Outcome in Mice. 
  • Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis. 
  • Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. 
  • Aromatic hydrocarbon receptor polymorphism: development of new methods to correlate genotype with phenotype. 
  • Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin. 
  • Arsenic Exposure, Blood DNA Methylation, and Cardiovascular Disease. 
  • Arsenic trioxide synergizes with everolimus (Rad001) to induce cytotoxicity of ovarian cancer cells through increased autophagy and apoptosis. 
  • Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. 
  • Arterial response to shear stress critically depends on endothelial TRPV4 expression. 
  • Arthritis syndromes associated with human T cell lymphotropic virus type I infection. 
  • Aryl Hydrocarbon Receptor Signaling Controls CD155 Expression on Macrophages and Mediates Tumor Immunosuppression. 
  • Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. 
  • Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells. 
  • Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness. 
  • Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis. 
  • Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages. 
  • Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. 
  • Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer. 
  • Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins. 
  • Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain. 
  • Assessing a role for enhancer-blocking activity in gene regulation within the murine T-cell receptor alpha/delta locus. 
  • Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation. 
  • Assessing overall risk in reproductive experiments. 
  • Assessing some dynamic properties of the living nervous system. 
  • Assessing the virulence of Cryptococcus neoformans causing meningitis in HIV infected and uninfected patients in Vietnam. 
  • Assessment of myeloma maintenance regimen of prednisone. Adriamycin, imuran, and vincristine in a murine plasmacytoma model. 
  • Assessment of photosensitizer dosimetry and tissue damage assay for photodynamic therapy in advanced-stage tumors. 
  • Assignment of the agent of Tyzzer's disease to Clostridium piliforme comb. nov. on the basis of 16S rRNA sequence analysis. 
  • Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16. 
  • Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms. 
  • Association between the 7 S RNA and the lupus La protein varies among cell types. 
  • Association of Variants in BAG3 With Cardiomyopathy Outcomes in African American Individuals. 
  • Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. 
  • Association of myosin light chain kinase with lymphocyte membrane-cytoskeleton complex. 
  • Association of protein kinase C(lambda) with adducin in 3T3-L1 adipocytes. 
  • Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction. 
  • Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. 
  • Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family. 
  • Associations of neighborhood concentrated poverty, neighborhood racial/ethnic composition, and indoor allergen exposures: a cross-sectional analysis of los angeles households, 2006-2008. 
  • Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate. 
  • Astatine-211 labeled anti-HER2 5F7 single domain antibody fragment conjugates: radiolabeling and preliminary evaluation. 
  • Astatine-211 labeling of internalizing anti-EGFRvIII monoclonal antibody using N-succinimidyl 5-[211At]astato-3-pyridinecarboxylate. 
  • Astatine-211-labeled biotin conjugates resistant to biotinidase for use in pretargeted radioimmunotherapy. 
  • Asteropsin A: an unusual cystine-crosslinked peptide from porifera enhances neuronal Ca2+ influx. 
  • Astringency: a more stringent definition. 
  • Astrocyte cytolysis by MHC class II-specific mouse T cell clones. 
  • Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. 
  • Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development. 
  • Astrocytes refine cortical connectivity at dendritic spines. 
  • Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. 
  • Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis. 
  • Asymmetric cell divisions promote stratification and differentiation of mammalian skin. 
  • Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. 
  • Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. 
  • Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis. 
  • Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. 
  • Atomic description of the immune complex involved in heparin-induced thrombocytopenia. 
  • Atrial chamber-specific expression of sarcolipin is regulated during development and hypertrophic remodeling. 
  • Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. 
  • Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin. 
  • Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase. 
  • Attenuation of acid induced oesophagitis in VR-1 deficient mice. 
  • Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase. 
  • Attenuation of herpes simplex virus neurovirulence with picornavirus cis-acting genetic elements. 
  • Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. 
  • Attenuation of the effects of punishment by ethanol: comparisons with chlordiazepoxide. 
  • Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6. 
  • Atypical antipsychotics rapidly and inappropriately switch peripheral fuel utilization to lipids, impairing metabolic flexibility in rodents. 
  • Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice. 
  • Augmentation of syngeneic tumor-specific immunity by semiallogeneic cell hybrids. 
  • Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. 
  • Augmented Responses to Ozone in Obese Mice Require IL-17A and Gastrin-Releasing Peptide. 
  • Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice. 
  • Aurora-A kinase is essential for bipolar spindle formation and early development. 
  • Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. 
  • Autism-associated mutation in Hevin/Sparcl1 induces endoplasmic reticulum stress through structural instability. 
  • Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. 
  • Autoantibodies against cell surface GRP78 promote tumor growth in a murine model of melanoma. 
  • Autoantibodies and their idiotypes. 
  • Autocrine BDNF-TrkB signalling within a single dendritic spine. 
  • Autocrine Complement Inhibits IL10-Dependent T-cell-Mediated Antitumor Immunity to Promote Tumor Progression. 
  • Autocrine inhibition of Na+/K(+)-ATPase by nitric oxide in mouse proximal tubule epithelial cells. 
  • Autocrine phosphorylation of p70(S6k) in response to acute stretch in myotubes. 
  • Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. 
  • Autocrine stimulation of mas oncogene leads to altered growth control. 
  • Autofeedback suppression of growth hormone (GH) secretion in transgenic mice expressing a human GH reporter targeted by tyrosine hydroxylase 5'-flanking sequences to the hypothalamus. 
  • Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition. 
  • Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. 
  • Autoimmunity: the nuclear arsenal of autoimmunity. 
  • Autologous stem cell transplantation for autoimmune diseases: issues in protocol development. 
  • Automated Recognition of Retinal Pigment Epithelium Cells on Limited Training Samples Using Neural Networks. 
  • Automated design of ligands to polypharmacological profiles. 
  • Automated feedback control of body temperature for small animal studies with MR microscopy. 
  • Automated radiochemical synthesis and biodistribution of [¹¹C]l-α-acetylmethadol ([¹¹C]LAAM). 
  • Automated segmentation of mouse brain images using extended MRF. 
  • Automated segmentation of neuroanatomical structures in multispectral MR microscopy of the mouse brain. 
  • Automated segmentation of the actively stained mouse brain using multi-spectral MR microscopy. 
  • Autophagic activity dictates the cellular response to oncogenic RAS. 
  • Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. 
  • Autophagy in the Aging and Experimental Ocular Hypertensive Mouse Model. 
  • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. 
  • Autophagy is essential for mitochondrial clearance in mature T lymphocytes. 
  • Autophagy is redundant for the host defense against systemic Candida albicans infections. 
  • Autophagy links inflammasomes to atherosclerotic progression. 
  • Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis. 
  • Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1. 
  • Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. 
  • Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. 
  • Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities. 
  • Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder. 
  • Autoradiographic analysis of nuclear estrogen binding sites during postnatal development of the genital tract of female mice. 
  • Autoreactive B cells recruited to lungs by silica exposure contribute to local autoantibody production in autoimmune-prone BXSB and B cell receptor transgenic mice. 
  • Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. 
  • Autoreceptor control of serotonin dynamics. 
  • Autoreceptor presynaptic control of dopamine release from striatum is lost at early stages of manganese poisoning. 
  • Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. 
  • Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs. 
  • Axin gene methylation status correlates with radiosensitivity of lung cancer cells. 
  • Axin2 regulates chondrocyte maturation and axial skeletal development. 
  • Axonal Odorant Receptors Mediate Axon Targeting. 
  • Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system. 
  • Axotomized mouse retinal ganglion cells containing melanopsin show enhanced survival, but not enhanced axon regrowth into a peripheral nerve graft. 
  • B Cell Subsets Differentially Contribute to the T Cell-Independent Memory Pool. 
  • B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse. 
  • B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation. 
  • B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin. 
  • B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity. 
  • B cell depletion reduces the development of atherosclerosis in mice. 
  • B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. 
  • B cell-directed therapies for autoimmune disease and correlates of disease response and relapse. 
  • B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice. 
  • B cells contribute to ischemia/reperfusion-mediated tissue injury. 
  • B cells in chronic graft-versus-host disease. 
  • B cells in chronic graft-versus-host disease. 
  • B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. 
  • B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. 
  • B lymphocytes differentially influence acute and chronic allograft rejection in mice. 
  • B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction. 
  • B lymphocytes: how they develop and function. 
  • B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae. 
  • B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models. 
  • B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody. 
  • B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals. 
  • B-cell targeting in chronic graft-versus-host disease. 
  • B-lymphocyte contributions to human autoimmune disease. 
  • B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice. 
  • B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. 
  • B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. 
  • B10 cell regulation of health and disease. 
  • B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. 
  • B7-H3-redirected chimeric antigen receptor T cells target glioblastoma and neurospheres. 
  • BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors. 
  • BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation. 
  • BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy. 
  • BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis. 
  • BALO: a "mini lung" model to study cell-cell interactions. 
  • BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. 
  • BCAA Supplementation in Mice with Diet-induced Obesity Alters the Metabolome Without Impairing Glucose Homeostasis. 
  • BCAA catabolism in brown fat controls energy homeostasis through SLC25A44. 
  • BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization. 
  • BCL2 interaction with actin in vitro may inhibit cell motility by enhancing actin polymerization. 
  • BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance. 
  • BDNF profoundly and specifically increases KCNQ4 expression in neurons derived from embryonic stem cells. 
  • BDNF regulates the maturation of inhibition and the critical period of plasticity in mouse visual cortex. 
  • BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. 
  • BEARscc determines robustness of single-cell clusters using simulated technical replicates. 
  • BET Bromodomain Inhibitors Which Permit Treg Function Enable a Combinatorial Strategy to Suppress GVHD in Pre-clinical Allogeneic HSCT. 
  • BET bromodomain inhibition of MYC-amplified medulloblastoma. 
  • BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. 
  • BLyS and APRIL in rheumatoid arthritis. 
  • BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis. 
  • BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment. 
  • BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning. 
  • BMP ligands act redundantly to pattern the dorsal telencephalic midline. 
  • BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. 
  • BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. 
  • BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors. 
  • BMP signaling in the development of the mouse esophagus and forestomach. 
  • BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. 
  • BMP-2 inhibits tumor growth of human renal cell carcinoma and induces bone formation. 
  • BMP-2 inhibits tumor-initiating ability in human renal cancer stem cells and induces bone formation. 
  • BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. 
  • BMP4 is essential for lens induction in the mouse embryo. 
  • BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth. 
  • BRAF Targeting Sensitizes Resistant Melanoma to Cytotoxic T Cells. 
  • BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. 
  • BRCA2 monoclonal antibodies react with differentiating epithelium. 
  • BRD4 Prevents R-Loop Formation and Transcription-Replication Conflicts by Ensuring Efficient Transcription Elongation. 
  • BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo. 
  • BRG1 is a biomarker of hypertrophic cardiomyopathy in human heart specimens. 
  • BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. 
  • BW2258U89: a GRP receptor antagonist which inhibits small cell lung cancer growth. 
  • Bacteria-host cell interaction mediated by cellular cholesterol/glycolipid-enriched microdomains. 
  • Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha. 
  • Bacterial endotoxin stimulates macrophages to release HMGB1 partly through CD14- and TNF-dependent mechanisms. 
  • Bacterial genetics by flow cytometry: rapid isolation of Salmonella typhimurium acid-inducible promoters by differential fluorescence induction. 
  • Bacterial infection of osteoblasts induces interleukin-1beta and interleukin-18 transcription but not protein synthesis. 
  • Bacterial lipopolysaccharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factor-alpha-dependent mechanism. 
  • Bacterial lipopolysaccharides and mycoplasmal lipoglycans: a comparison between their abilities to induce macrophage-mediated tumor cell killing and Limulus amebocyte lysate clotting. 
  • Bacterial penetration of bladder epithelium through lipid rafts. 
  • Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad. 
  • Baculovirus-infected insect cells expressing peptide-MHC complexes elicit protective antitumor immunity. 
  • Balance of Irgm protein activities determines IFN-gamma-induced host defense. 
  • Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem. 
  • Bartonella henselae: etiology of pulmonary nodules in a patient with depressed cell-mediated immunity. 
  • Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin. 
  • Basal cells as stem cells of the mouse trachea and human airway epithelium. 
  • Basal epithelial stem cells are efficient targets for prostate cancer initiation. 
  • Basal ganglia outputs map instantaneous position coordinates during behavior. 
  • Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E. 
  • Base mutations in the terminal noncoding regions of the genome of vesicular stomatitis virus isolated from persistent infections of L cells. 
  • Basement membranes. 
  • Basic fibroblast growth factor downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells. 
  • BayFish: Bayesian inference of transcription dynamics from population snapshots of single-molecule RNA FISH in single cells. 
  • Bayesian analysis of signaling networks governing embryonic stem cell fate decisions. 
  • Bayesian inferences on umbrella orderings. 
  • Bayesian latent variable models for mixed discrete outcomes. 
  • Bayesian models for multivariate current status data with informative censoring. 
  • Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease. 
  • Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. 
  • Bcl-2 accelerates multistep prostate carcinogenesis in vivo. 
  • Bcl-xL is an oncogenic driver in colorectal cancer. 
  • Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin. 
  • Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release. 
  • Beat frequency is bimodally distributed in spermatozoa from T/t12 mice. 
  • Behavioral and neurochemical changes in folate-deficient mice. 
  • Behavioral characterization of P311 knockout mice. 
  • Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid. 
  • Behavioral manipulation of the diabetic phenotype in ob/ob mice. 
  • Behavioral phenotyping of transgenic and knockout animals: a cautionary tale. 
  • Behavioral responses to social stress in noradrenaline transporter knockout mice: effects on social behavior and depression. 
  • Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. 
  • Being there: cellular targeting of voltage-gated sodium channels in the heart. 
  • Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis. 
  • Beneficial effects of the Rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis. 
  • Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses. 
  • Bergmann glia and the recognition molecule CHL1 organize GABAergic axons and direct innervation of Purkinje cell dendrites. 
  • Beryllium fluoride-induced cell proliferation: a process requiring P21(ras)-dependent activated signal transduction and NF-kappaB-dependent gene regulation. 
  • Beta-adrenergic axis and heart disease. 
  • Beta-adrenergic regulation of cholecystokinin secretion in STC-1 cells. 
  • Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors. 
  • Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. 
  • Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. 
  • Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression. 
  • Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. 
  • Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. 
  • Beta-arrestin-2 regulates the development of allergic asthma. 
  • Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. 
  • Beta-arrestin-mediated localization of smoothened to the primary cilium. 
  • Beta-arrestin-mediated signaling regulates protein synthesis. 
  • Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis. 
  • Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. 
  • Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. 
  • Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle. 
  • Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. 
  • Beta-caryophyllene enhances wound healing through multiple routes. 
  • Beta-catenin and transforming growth factor beta have distinct roles regulating fibroblast cell motility and the induction of collagen lattice contraction. 
  • Beta-catenin is a mediator of the response of fibroblasts to irradiation. 
  • Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. 
  • Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation. 
  • Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. 
  • Beta1-adrenergic receptors maintain fetal heart rate and survival. 
  • Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction. 
  • Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms. 
  • Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels. 
  • Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. 
  • Bevacizumab-induced alterations in vascular permeability and drug delivery: a novel approach to augment regional chemotherapy for in-transit melanoma. 
  • Bezafibrate induces autophagy and improves hepatic lipid metabolism in glycogen storage disease type Ia. 
  • Bi-allelic Variants in TONSL Cause SPONASTRIME Dysplasia and a Spectrum of Skeletal Dysplasia Phenotypes. 
  • Bi-ligand surfaces with oriented and patterned protein for real-time tracking of cell migration. 
  • Biallelic mutations in FDXR cause neurodegeneration associated with inflammation. 
  • Biased Expression of the FOXP3Δ3 Isoform in Aggressive Bladder Cancer Mediates Differentiation and Cisplatin Chemotherapy Resistance. 
  • Biased agonists of the chemokine receptor CXCR3 differentially control chemotaxis and inflammation. 
  • Bicarbonate alters cellular responses in respiration assays. 
  • Bidirectional modulation of substantia nigra activity by motivational state. 
  • Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. 
  • Bifidobacterium animalis subsp. lactis 420 mitigates the pathological impact of myocardial infarction in the mouse. 
  • Biliary excretion of glycolipid in induced or inherited glucosylceramide lipidosis. 
  • Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci. 
  • Binary Fate Choice between Closely Related Interneuronal Types Is Determined by a Fezf1-Dependent Postmitotic Transcriptional Switch. 
  • Binding and endocytosis of alpha 2-macroglobulin-plasmin complexes. 
  • Binding kinetics of superantigen with TCR and MHC class II. 
  • Binding of rat alpha 1-inhibitor-3-methylamine to the alpha 2-macroglobulin signaling receptor induces second messengers. 
  • Binding of receptor-recognized forms of alpha2-macroglobulin to the alpha2-macroglobulin signaling receptor activates phosphatidylinositol 3-kinase. 
  • Binding of rituximab, trastuzumab, cetuximab, or mAb T101 to cancer cells promotes trogocytosis mediated by THP-1 cells and monocytes. 
  • Binding of tenascin-C to soluble fibronectin and matrix fibrils. 
  • Binding specificity of a monoclonal anti-DNA antibody. 
  • Binocular deprivation induces both age-dependent and age-independent forms of plasticity in parvalbumin inhibitory neuron visual response properties. 
  • Bio imaging of intracellular NO production in single bone cells after mechanical stimulation. 
  • Bioaccumulation of Novel Per- and Polyfluoroalkyl Substances in Mice Dosed with an Aqueous Film-Forming Foam. 
  • Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site. 
  • Biochemical and biomechanical characteristics of dystrophin-deficient mdx3cv mouse lens. 
  • Biochemical and immunological abnormalities in purine nucleoside phosphorylase deficient mice. 
  • Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF). 
  • Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models. 
  • Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits. 
  • Biochemical properties of recombinant human and mouse N-acetylglutamate synthase. 
  • Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications. 
  • Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL. 
  • Bioelectrorheological model of the cell. 5. Electrodestruction of cellular membrane in alternating electric field. 
  • Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. 
  • Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation. 
  • Biologic and biochemical activities of continuous macrophage cell lines P388D1 and J774.1. 
  • Biological Principles of Stereotactic Body Radiation Therapy (SBRT) and Stereotactic Radiation Surgery (SRS): Indirect Cell Death. 
  • Biological Role and Therapeutic Potential of IDH Mutations in Cancer. 
  • Biological activity of complement in vivo. Role of C5 in the accumulation of polymorphonuclear leukocytes in inflammatory exudates. 
  • Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene. 
  • Biological basis of germline mutation: comparisons of spontaneous germline mutation rates among drosophila, mouse, and human. 
  • Biological effects of desert dust in respiratory epithelial cells and a murine model. 
  • Biological evaluation of ring- and side-chain-substituted m-iodobenzylguanidine analogues. 
  • Biological evaluation of some biphenyl analogs of acetyl-seco-hemicholinium No. 3. 
  • Biological evaluation of some terphenyl analogs of hemicholinium No. 3. 
  • Biological functions and transcriptional targets of CaRF in neurons. 
  • Biological magnetic resonance imaging using laser-polarized 129Xe. 
  • Biological responses to TGF-β in the mammary epithelium show a complex dependency on Smad3 gene dosage with important implications for tumor progression. 
  • Biological, clinical and population relevance of 95 loci for blood lipids. 
  • Biological, immunological, and biochemical evidence that HIX virus is a recombinant between Moloney leukemia virus and a murine xenotropic C type virus. 
  • Biology of gliomas: potential clinical implications of glioma cellular heterogeneity. 
  • Biology of hepatocellular neoplasia in the mouse. I. Histogenesis of safrole-induced hepatocellular carcinoma. 
  • Biology of hepatocellular neoplasia in the mouse. II. Sequential enzyme histochemical analysis of BALB/c mouse liver during safrole-induced carcinogenesis. 
  • Biology of hepatocellular neoplasia in the mouse. III. Electron microscopy of safrole-induced hepatocellular adenomas and hepatocellular carcinomas. 
  • Biology of small cell lung cancer. 
  • Bioluminescence imaging to track bacterial dissemination of Yersinia pestis using different routes of infection in mice. 
  • Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells. 
  • Bioluminescent virion shells: new tools for quantitation of AAV vector dynamics in cells and live animals. 
  • Biomaterial-mediated retroviral gene transfer using self-assembled monolayers. 
  • Biomedicine. Insulin resistance takes a trip through the ER. 
  • Biomimetic Hydrogels with Immobilized EphrinA1 for Therapeutic Angiogenesis 
  • Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo. 
  • Biomimetic hydrogels with pro-angiogenic properties. 
  • Biomimetic, synthetic HDL nanostructures for lymphoma. 
  • Biophysical properties of the zona pellucida measured by capillary suction: is zona hardening a mechanical phenomenon? 
  • Bioplasmonic calligraphy for multiplexed label-free biodetection. 
  • Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity. 
  • Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). 
  • Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s). 
  • Biosynthesis of renin: multiplicity of active and intermediate forms. 
  • Biosynthetically intriguing chlorinated lipophilic metabolites from geographically distant tropical marine cyanobacteria. 
  • Birinapant Enhances Gemcitabine's Antitumor Efficacy in Triple-Negative Breast Cancer by Inducing Intrinsic Pathway-Dependent Apoptosis. 
  • Birthdays of retinal amacrine cell subtypes are systematically related to their molecular identity and soma position. 
  • Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. 
  • Bisphenol A exposure alters placentation and causes preeclampsia-like features in pregnant mice involved in reprogramming of DNA methylation of WNT2. 
  • Bisphosphate nucleotidase 2 (BPNT2), a molecular target of lithium, regulates chondroitin sulfation patterns in the cerebral cortex and hippocampus. 
  • Bisphosphonates target B cells to enhance humoral immune responses. 
  • Black cohosh increases metastatic mammary cancer in transgenic mice expressing c-erbB2. 
  • Bladder sensory physiology: neuroactive compounds and receptors, sensory transducers, and target-derived growth factors as targets to improve function. 
  • Blockade of T- and B-lymphocyte development by antibody to the gamma c subunit of the receptors for interleukins 2, 4, and 7. 
  • Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists. 
  • Blockade of nicotinic acetylcholine receptors suppresses hippocampal long-term potentiation in wild-type but not ApoE4 targeted replacement mice. 
  • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. 
  • Blockade of the natriuretic peptide clearance receptor attenuates proteinuria in a mouse model of focal segmental glomerulosclerosis. 
  • Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis. 
  • Blocking Cyclin-Dependent Kinase 4/6 During Single Dose Versus Fractionated Radiation Therapy Leads to Opposite Effects on Acute Gastrointestinal Toxicity in Mice. 
  • Blocking [211At]astatide accumulation in normal tissues: preliminary evaluation of seven potential compounds. 
  • Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice. 
  • Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration. 
  • Blood gene expression signatures predict invasive candidiasis. 
  • Blood pressure homeostasis is maintained by a P311-TGF-β axis. 
  • Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding. 
  • Blood-Brain Barrier Permeability Is Regulated by Lipid Transport-Dependent Suppression of Caveolae-Mediated Transcytosis. 
  • Blood-brain barrier (BBB) disruption using a diagnostic ultrasound scanner and Definity in Mice. 
  • Blood-brain barrier dysfunction after primary blast injury in vitro. 
  • Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. 
  • Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization. 
  • Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase. 
  • Blurring the edges in vertebrate sex determination. 
  • Bmp signaling is required for intestinal growth and morphogenesis. 
  • Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. 
  • Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis. 
  • Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. 
  • Bmp4 is required for the generation of primordial germ cells in the mouse embryo. 
  • Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration. 
  • Bmp7 regulates germ cell proliferation in mouse fetal gonads. 
  • Bmps: multifunctional regulators of mammalian embryonic development. 
  • Body weight and fat deposition in prolactin receptor-deficient mice. 
  • Body weight is not always a good predictor of longevity in mice. 
  • Bombesin and [Leu8]phyllolitorin promote fetal mouse lung branching morphogenesis via a receptor-mediated mechanism. 
  • Bombesin increases fetal lung growth and maturation in utero and in organ culture. 
  • Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice. 
  • Bombesin may play a role in fetal lung growth and maturation in utero and in lung organ culture. 
  • Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung. 
  • Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia? 
  • Bone Marrow Stress Decreases Osteogenic Progenitors. 
  • Bone Marrow-Derived Monocytes Drive the Inflammatory Microenvironment in Local and Remote Regions after Thoracic Spinal Cord Injury. 
  • Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression. 
  • Bone formation induced by BMP-2 in human osteosarcoma cells. 
  • Bone marrow chimeras and c-fms conditional ablation (Mafia) mice reveal an essential role for resident myeloid cells in lipopolysaccharide/TLR4-induced corneal inflammation. 
  • Bone marrow dendritic cell-mediated regulation of TLR and B cell receptor signaling in B cells. 
  • Bone marrow transplantation augments the effect of brain- and spinal cord-directed adeno-associated virus 2/5 gene therapy by altering inflammation in the murine model of globoid-cell leukodystrophy. 
  • Bone marrow transplantation transfers age-related susceptibility to neovascular remodeling in murine laser-induced choroidal neovascularization. 
  • Bone marrow-derived AXL tyrosine kinase promotes mitogenic crosstalk and cardiac allograft vasculopathy. 
  • Bone marrow-derived dendritic cells pulsed with tumor homogenate induce immunity against syngeneic intracerebral glioma. 
  • Bone marrow-derived mesenchymal stem cells undergo JCV T-antigen mediated transformation and generate tumors with neuroectodermal characteristics. 
  • Bone marrow-derived progenitor cells contribute to experimental choroidal neovascularization. 
  • Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors. 
  • Bone morphogenetic protein 2 opposes Shh-mediated proliferation in cerebellar granule cells through a TIEG-1-based regulation of Nmyc. 
  • Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse. 
  • Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-dependent signaling pathway. 
  • Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. 
  • Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. 
  • Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons. 
  • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. 
  • Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. 
  • Bone targeting nanocarrier-assisted delivery of adenosine to combat osteoporotic bone loss. 
  • Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model. 
  • Boosting cardiac contractility with genes. 
  • Boosting high-intensity focused ultrasound-induced anti-tumor immunity using a sparse-scan strategy that can more effectively promote dendritic cell maturation. 
  • Borg proteins control septin organization and are negatively regulated by Cdc42. 
  • Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. 
  • Both Hematopoietic- and Non-hematopoietic-derived {beta}-arrestin-2 Regulates Murine Allergic Airway Disease. 
  • Both selenium deficiency and modest selenium supplementation lead to myocardial fibrosis in mice via effects on redox-methylation balance. 
  • Botulinum Neurotoxin A injections influence stretching of the gastrocnemius muscle-tendon unit in an animal model. 
  • Bovine thrombin and systemic autoimmunity. 
  • Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ. 
  • Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. 
  • Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. 
  • Brain Metastasis Cell Lines Panel: A Public Resource of Organotropic Cell Lines. 
  • Brain cancer stem cells display preferential sensitivity to Akt inhibition. 
  • Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier. 
  • Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. 
  • Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice. 
  • Brain stem as a target site for the metabolic side effects of olanzapine. 
  • Brain tumors in man and animals: report of a workshop. 
  • Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa). 
  • Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo. 
  • Brain-derived neurotrophic factor overexpression induces precocious critical period in mouse visual cortex. 
  • Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight. 
  • Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability. 
  • Brain-wide electrical dynamics encode individual appetitive social behavior. 
  • Branched-chain α-ketoacids are preferentially reaminated and activate protein synthesis in the heart. 
  • Branching morphogenesis of the lung: new models for a classical problem. 
  • Breaking or making immunological privilege in the central nervous system: the regulation of immunity by neuropeptides. 
  • Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. 
  • Bridged peptide macrocycles as ligands for PDZ domain proteins. 
  • Bridging the translational gap: Implementation of multimodal small animal imaging strategies for tumor burden assessment in a co-clinical trial. 
  • Broad immunophenotyping of the murine brain tumor microenvironment. 
  • Bromelain treatment decreases neutrophil migration to sites of inflammation. 
  • Bromodeoxyuridine-mediated radiosensitization in human glioma: the effect of concentration, duration, and fluoropyrimidine modulation. 
  • Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans. 
  • Bronchial epithelial injury in the context of alloimmunity promotes lymphocytic bronchiolitis through hyaluronan expression. 
  • Bronchus-associated lymphoid tissue-resident Foxp3+ T lymphocytes prevent antibody-mediated lung rejection. 
  • Brush border enzyme-cleavable linkers: Evaluation for reducing renal uptake of radiolabeled prostate-specific membrane antigen inhibitors. 
  • Building and maintaining the epithelium of the lung. 
  • Building and re-building the heart by cardiomyocyte proliferation. 
  • Buprenorphine metabolites, buprenorphine-3-glucuronide and norbuprenorphine-3-glucuronide, are biologically active. 
  • Burst-Dependent Bidirectional Plasticity in the Cerebellum Is Driven by Presynaptic NMDA Receptors. 
  • Busulfan therapy of central nervous system xenografts in athymic mice. 
  • Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts. 
  • C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration. 
  • C-C Motif Chemokine Receptor 7 Exacerbates Hypertension Through Effects on T Lymphocyte Trafficking. 
  • C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independent. 
  • C-terminal deletion of the atrophin-1 protein results in growth retardation but not neurodegeneration in mice. 
  • C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity. 
  • C-type virus particles in human urogenital tumours after heterotransplantation into nude mice. 
  • C/EBPβ controls exercise-induced cardiac growth and protects against pathological cardiac remodeling. 
  • C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway. 
  • C8ORF37 Is Required for Photoreceptor Outer Segment Disc Morphogenesis by Maintaining Outer Segment Membrane Protein Homeostasis. 
  • CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC. 
  • CBF, Myb, and Ets binding sites are important for activity of the core I element of the murine retrovirus SL3-3 in T lymphocytes. 
  • CBX2 is required to stabilize the testis pathway by repressing Wnt signaling. 
  • CCAAT/enhancer-binding protein alpha is required for transcription of the beta 3-adrenergic receptor gene during adipogenesis. 
  • CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice. 
  • CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells. 
  • CCI-779 inhibits cell-cycle G2-M progression and invasion of castration-resistant prostate cancer via attenuation of UBE2C transcription and mRNA stability. 
  • CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue. 
  • CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors. 
  • CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis. 
  • CCN1 Regulates Chondrocyte Maturation and Cartilage Development. 
  • CCP1 promotes mitochondrial fusion and motility to prevent Purkinje cell neuron loss in pcd mice. 
  • CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension. 
  • CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality. 
  • CCR2-antagonist prophylaxis reduces pulmonary immune pathology and markedly improves survival during influenza infection. 
  • CCR5 Signaling Promotes Murine and Human Hematopoietic Regeneration following Ionizing Radiation. 
  • CCR7 is critical for the induction and maintenance of Th17 immunity in dry eye disease. 
  • CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway. 
  • CD10/neutral endopeptidase 24.11 regulates fetal lung growth and maturation in utero by potentiating endogenous bombesin-like peptides. 
  • CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. 
  • CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages. 
  • CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation. 
  • CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. 
  • CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling. 
  • CD19 and CD22 regulate a B lymphocyte signal transduction pathway that contributes to autoimmunity. 
  • CD19 can regulate B lymphocyte signal transduction independent of complement activation. 
  • CD19 expression in B cells is important for suppression of contact hypersensitivity. 
  • CD19 expression in B cells regulates atopic dermatitis in a mouse model. 
  • CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19. 
  • CD19 hyperexpression augments Sle1-induced humoral autoimmunity but not clinical nephritis. 
  • CD19 maps to a region of conservation between human chromosome 16 and mouse chromosome 7. 
  • CD19 regulates B lymphocyte responses to transmembrane signals. 
  • CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity. 
  • CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. 
  • CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. 
  • CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma. 
  • CD19 regulates the development of bleomycin-induced pulmonary fibrosis in a mouse model. 
  • CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction. 
  • CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling. 
  • CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse. 
  • CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes. 
  • CD19: a promising B cell target for rheumatoid arthritis. 
  • CD20 deficiency in humans results in impaired T cell-independent antibody responses. 
  • CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression. 
  • CD22 and CD72 cooperatively contribute to the development of the reverse Arthus reaction model. 
  • CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions. 
  • CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. 
  • CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. 
  • CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo. 
  • CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor. 
  • CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms. 
  • CD22 regulates time course of both B cell division and antibody response. 
  • CD22 serves as a receptor for soluble IgM. 
  • CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. 
  • CD22-Binding Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22 Ligand-Dependent and Independent Pathways, and Enhance Antibody Production in Mice. 
  • CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. 
  • CD25+CD4+ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover. 
  • CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. 
  • CD28 costimulatory signal induces protein arginine methylation in T cells. 
  • CD28 is required for germinal center formation. 
  • CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin. 
  • CD4 T-Cell Exhaustion: Does It Exist and What Are Its Roles in Cancer? 
  • CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. 
  • CD4(+) T cells contribute to the remodeling of the microenvironment required for sustained tumor regression upon oncogene inactivation. 
  • CD4+CD25+Foxp3+ Tregs resolve experimental lung injury in mice and are present in humans with acute lung injury. 
  • CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin. 
  • CD4+Thy1- thymocytes with a Th-type 2 cytokine response. 
  • CD44--a molecule involved in leukocyte adherence and T-cell activation. 
  • CD47 blockade augmentation of trastuzumab antitumor efficacy dependent on antibody-dependent cellular phagocytosis. 
  • CD6. 
  • CD62L- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice. 
  • CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements. 
  • CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis. 
  • CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines. 
  • CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver. 
  • CD83 expression influences CD4+ T cell development in the thymus. 
  • CD83 expression is a sensitive marker of activation required for B cell and CD4+ T cell longevity in vivo. 
  • CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells. 
  • CD83: a regulatory molecule of the immune system with great potential for therapeutic application. 
  • CD86 (B7-2) can function to drive MHC-restricted antigen-specific CTL responses in vivo. 
  • CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. 
  • CD98-induced CD147 signaling stabilizes the Foxp3 protein to maintain tissue homeostasis. 
  • CDK2 activation in mouse epidermis induces keratinocyte proliferation but does not affect skin tumor development. 
  • CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control. 
  • CDK5 regulates cell adhesion and migration in corneal epithelial cells. 
  • CEA/CD3-bispecific T cell-engaging (BiTE) antibody-mediated T lymphocyte cytotoxicity maximized by inhibition of both PD1 and PD-L1. 
  • CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. 
  • CFLAR/c-FLIPL: a star in the autophagy, apoptosis and necroptosis alliance. 
  • CFTR as a cAMP-dependent regulator of sodium channels. 
  • CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. 
  • CHK1 protects oncogenic KRAS-expressing cells from DNA damage and is a target for pancreatic cancer treatment. 
  • CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. 
  • CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation. 
  • CK1epsilon is required for breast cancers dependent on beta-catenin activity. 
  • CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch. 
  • CLN3p impacts galactosylceramide transport, raft morphology, and lipid content. 
  • CLN5 and CLN8 protein association with ceramide synthase: biochemical and proteomic approaches. 
  • CNS inflammation and bone marrow neuropathy in type 1 diabetes. 
  • CNS myelin wrapping is driven by actin disassembly. 
  • CODAS syndrome is associated with mutations of LONP1, encoding mitochondrial AAA+ Lon protease. 
  • COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. 
  • COVA1-18 neutralizing antibody protects against SARS-CoV-2 in three preclinical models. 
  • COX-2-derived prostacyclin modulates vascular remodeling. 
  • CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. 
  • CRISPR genome editing in stem cells turns to gold. 
  • CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues. 
  • CSF1 receptor targeting in prostate cancer reverses macrophage-mediated resistance to androgen blockade therapy. 
  • CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer. 
  • CTLA-4-Mediated inhibition of early events of T cell proliferation. 
  • CVN-AD Alzheimer's mice show premature reduction in neurovascular coupling in response to spreading depression and anoxia compared to aged controls. 
  • CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden. 
  • CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. 
  • CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. 
  • CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5. 
  • CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival. 
  • CXCR2 promotes ovarian cancer growth through dysregulated cell cycle, diminished apoptosis, and enhanced angiogenesis. 
  • CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin. 
  • CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis. 
  • CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels. 
  • CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. 
  • CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis. 
  • CYP7B1: one cytochrome P450, two human genetic diseases, and multiple physiological functions. 
  • Ca(2+)-regulated serine protease associated with the nuclear scaffold. 
  • Ca(2+)/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix. 
  • Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium. 
  • Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. 
  • CaMKII is essential for the proasthmatic effects of oxidation. 
  • CaMKK2 in myeloid cells is a key regulator of the immune-suppressive microenvironment in breast cancer. 
  • Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos. 
  • Cadherin-6 expression transiently delineates specific rhombomeres, other neural tube subdivisions, and neural crest subpopulations in mouse embryos. 
  • Cadmium-induced DNA synthesis and cell proliferation in macrophages: the role of intracellular calcium and signal transduction mechanisms. 
  • Cadmium-induced neoplastic transformation of human prostate epithelial cells. 
  • Caffeine prevents restenosis and inhibits vascular smooth muscle cell proliferation through the induction of autophagy. 
  • Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. 
  • Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo. 
  • Calcineurin activation causes retinal ganglion cell degeneration. 
  • Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis. 
  • Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus. 
  • Calcineurin controls hyphal growth, virulence, and drug tolerance of Candida tropicalis. 
  • Calcineurin enhances acetylcholinesterase mRNA stability during C2-C12 muscle cell differentiation. 
  • Calcineurin governs thermotolerance and virulence of Cryptococcus gattii. 
  • Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain. 
  • Calcineurin is essential for Candida albicans survival in serum and virulence. 
  • Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae. 
  • Calcineurin mediates pancreatic growth in protease inhibitor-treated mice. 
  • Calcineurin mutants render T lymphocytes resistant to cyclosporin A. 
  • Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. 
  • Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy. 
  • Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. 
  • Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. 
  • Calcineurin-NFAT signaling, together with GABP and peroxisome PGC-1{alpha}, drives utrophin gene expression at the neuromuscular junction. 
  • Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms. 
  • Calcitonin gene-related peptide (CGRP) in the developing mouse limb. 
  • Calcitonin stimulation of renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity in hypophosphatemic mice. Evidence that the regulation of calcitriol production is not universally abnormal in X-linked hypophosphatemia. 
  • Calcium binding by synaptotagmin's C2A domain is an essential element of the electrostatic switch that triggers synchronous synaptic transmission. 
  • Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues. 
  • Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage. 
  • Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development. 
  • Calcium, calmodulin and cell proliferation. 
  • Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. 
  • Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4. 
  • Calcium-dependent cytosolic phospholipase A2 activation is implicated in neuroinflammation and oxidative stress associated with ApoE4. 
  • Calcium-dependent regulation of cholecystokinin secretion and potassium currents in STC-1 cells. 
  • Calcium/Calmodulin Dependent Protein Kinase Kinase 2 Regulates the Expansion of Tumor-Induced Myeloid-Derived Suppressor Cells. 
  • Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration. 
  • Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses. 
  • Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology. 
  • Calibration-free absolute quantification of particle concentration by statistical analyses of photoacoustic signals in vivo. 
  • Calibration-free structured-illumination photoacoustic flowgraphy of transverse flow in scattering media. 
  • Calmodulin as a regulator of cell growth and gene expression. 
  • Calmodulin as an integral subunit of phosphorylase kinase from rabbit skeletal muscle. 
  • Calmodulin is involved in regulation of cell proliferation. 
  • Calmodulin is required for cell-cycle progression during G1 and mitosis. 
  • Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase. 
  • Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. 
  • Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. 
  • Calmodulin-induced early-onset diabetes in transgenic mice. 
  • Calmodulin-microtubule association in cultured mammalian cells. 
  • Calorie restriction alleviates the age-related decrease in neural progenitor cell division in the aging brain. 
  • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. 
  • Calponin-3 deficiency augments contractile activity, plasticity, fibrogenic response and Yap/Taz transcriptional activation in lens epithelial cells and explants. 
  • Calreticulin chaperones regulate functional expression of vomeronasal type 2 pheromone receptors. 
  • Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides. 
  • Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene. 
  • Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae? 
  • Can the thymus win the battle against drug-resistant HIV? 
  • Cancer clocks in tumourigenesis: the p53 pathway and beyond. 
  • Cancer immunotherapy innovator James Allison receives the 2015 Lasker~DeBakey Clinical Medical Research Award. 
  • Cancer in rodents: does it tell us about cancer in humans? 
  • Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma. 
  • Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. 
  • Cancer-specific type-I interferon receptor signaling promotes cancer stemness and effector CD8+ T-cell exhaustion. 
  • Cannabinoids. Synthesis and central nervous system activity of 8-substituted 10-hydroxy-5,5-dimethyl-5H-[1]benzopyrano[4,3-c]pyridine and derivatives. 
  • Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. 
  • Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species. 
  • Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways. 
  • Capillary isoelectric-focusing immunoassays to study dynamic oncoprotein phosphorylation and drug response to targeted therapies in non-small cell lung cancer. 
  • Capric acid and hydroxypropylmethylcellulose increase the immunogenicity of nasally administered peptide vaccines. 
  • Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis. 
  • Capture of phosphopeptides using alpha-zirconium phosphate nanoplatelets. 
  • Capturing and Manipulating Activated Neuronal Ensembles with CANE Delineates a Hypothalamic Social-Fear Circuit. 
  • Capturing the primordial Kras mutation initiating urethane carcinogenesis. 
  • Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice. 
  • Carbohydrate Microarrays Identify Blood Group Precursor Cryptic Epitopes as Potential Immunological Targets of Breast Cancer. 
  • Carbohydrate changes in pre- and peri-implantation mouse embryos as detected by a monoclonal antibody. 
  • Carbohydrate recognition systems in amphibians: primitive alpha 2-macroglobulin receptors. 
  • Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer. 
  • Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. 
  • Carbon chain shape selectivity by the mouse olfactory receptor OR-I7. 
  • Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance. 
  • Carbon monoxide modulates Fas/Fas ligand, caspases, and Bcl-2 family proteins via the p38alpha mitogen-activated protein kinase pathway during ischemia-reperfusion lung injury. 
  • Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway. 
  • Carbonylation of adipose proteins in obesity and insulin resistance: identification of adipocyte fatty acid-binding protein as a cellular target of 4-hydroxynonenal. 
  • Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice. 
  • Carcinogen induced unscheduled DNA synthesis in mouse hepatocytes. 
  • Carcinogenicity and toxicity of inhaled nitrobenzene in B6C3F1 mice and F344 and CD rats. 
  • Carcinogenicity of inhaled benzene in CBA mice. 
  • Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. 
  • Cardiac CaV1.2 channels require β subunits for β-adrenergic-mediated modulation but not trafficking. 
  • Cardiac GPCRs: GPCR signaling in healthy and failing hearts. 
  • Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice. 
  • Cardiac arrest and resuscitation activates the hypothalamic-pituitary-adrenal axis and results in severe immunosuppression. 
  • Cardiac arrest/cardiopulmonary resuscitation augments cell-mediated immune function and transiently suppresses humoral immune function. 
  • Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure. 
  • Cardiac cell therapy in vitro: reproducible assays for comparing the efficacy of different donor cells. 
  • Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs. 
  • Cardiac dysregulation following intrahippocampal kainate-induced status epilepticus. 
  • Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. 
  • Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. 
  • Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. 
  • Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy. 
  • Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice that express the amino terminus of beta-ARK1. 
  • Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene. 
  • Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice. 
  • Cardiac muscle cell hypertrophy and apoptosis induced by distinct members of the p38 mitogen-activated protein kinase family. 
  • Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload. 
  • Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts. 
  • Cardiac rupture after myocardial infarction: new insights from murine models. 
  • Cardiac vulnerability to ischemia/reperfusion injury drastically increases in late pregnancy. 
  • Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. 
  • Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. 
  • Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling. 
  • Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects. 
  • Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. 
  • Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling. 
  • Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues. 
  • Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart. 
  • Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. 
  • Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia. 
  • Cardioprotective role of S-nitrosylated hemoglobin from rbc. 
  • Cardiovascular Metabolomics. 
  • Cardiovascular abnormalities in transgenic mice with reduced brown fat: an animal model of human obesity. 
  • Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors. 
  • Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA. 
  • Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo. 
  • Carnitine revisited: potential use as adjunctive treatment in diabetes. 
  • Cartilage tissue engineering: Directed differentiation of embryonic stem cells in three-dimensional hydrogel culture. 
  • Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. 
  • Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis. 
  • Cartilage-binding antibodies induce pain through immune complex-mediated activation of neurons. 
  • Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development. 
  • Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development. 
  • Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. 
  • Casein kinase I in the mammalian circadian clock. 
  • Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy. 
  • Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. 
  • Caspase-1-induced pyroptosis is an innate immune effector mechanism against intracellular bacteria. 
  • Caspase-11 protects against bacteria that escape the vacuole. 
  • Caspase-2 impacts lung tumorigenesis and chemotherapy response in vivo. 
  • Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease. 
  • Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT. 
  • Caspase-3 dependent cleavage and activation of skeletal muscle phosphorylase b kinase. 
  • Caspase-3 promotes genetic instability and carcinogenesis. 
  • Caspase-7 activates ASM to repair gasdermin and perforin pores. 
  • Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. 
  • Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice. 
  • Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. 
  • Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis. 
  • Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. 
  • Catabolic pathways for streptokinase, plasmin, and streptokinase activator complex in mice. In vivo reaction of plasminogen activator with alpha 2-macroglobulin. 
  • Catabolism of branched-chain amino acids in heart failure: insights from genetic models. 
  • Catabolism of human tissue plasminogen activator in mice. 
  • Catabolism of radioiodinated murine monoclonal antibody F(ab')2 fragment labeled using N-succinimidyl 3-iodobenzoate and Iodogen methods. 
  • Catabolism of streptokinase and polyethylene glycol-streptokinase: evidence for transport of intact forms through the biliary system in the mouse. 
  • Cataract in mice congenitally infected with Toxoplasma gondii. 
  • Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. 
  • Catecholaminergic cell lines from the brain and adrenal glands of tyrosine hydroxylase-SV40 T antigen transgenic mice. 
  • Catecholamines act via a beta-adrenergic receptor to maintain fetal heart rate and survival. 
  • Cathepsin E promotes pulmonary emphysema via mitochondrial fission. 
  • Cathepsin K-sensitive poly(ethylene glycol) hydrogels for degradation in response to bone resorption. 
  • Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4. 
  • Caveats to the use of MTT, neutral red, Hoechst and Resazurin to measure silver nanoparticle cytotoxicity. 
  • Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma. 
  • Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments. 
  • Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations. 
  • Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. 
  • Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. 
  • Cdk2 deficiency decreases ras/CDK4-dependent malignant progression, but not myc-induced tumorigenesis. 
  • Ceftaroline: a cephalosporin with expanded Gram-positive activity. 
  • Ceftriaxone pharmacokinetics in interleukin-10-treated murine pneumococcal pneumonia. 
  • Celecoxib does not delay cutaneous wound healing in haemophilia B mice. 
  • Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity. 
  • Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. 
  • Cell adhesion: separation of p120's powers? 
  • Cell autonomous role of PTEN in regulating castration-resistant prostate cancer growth. 
  • Cell binding and tumor inhibiting functions of a new antihuman melanoma murine monoclonal antibody. 
  • Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene. 
  • Cell biology. Propelling progeny. 
  • Cell culture models to study retinal pigment epithelium-related pathogenesis in age-related macular degeneration. 
  • Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587). 
  • Cell death in age-related macular degeneration. 
  • Cell interactions and endoderm differentiation in cultured mouse embryos. 
  • Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm. 
  • Cell lineage mapping of taste bud cells and keratinocytes in the mouse tongue and soft palate. 
  • Cell population dynamics model for deconvolution of murine embryonic stem cell self-renewal and differentiation responses to cytokines and extracellular matrix. 
  • Cell proliferation is necessary for the determination of male fate in the gonad. 
  • Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII. 
  • Cell surface-associated proteins which bind native type IV collagen or gelatin. 
  • Cell therapy for diverse central nervous system disorders: inherited metabolic diseases and autism. 
  • Cell therapy in murine atherosclerosis: in vivo imaging with high-resolution helical SPECT. 
  • Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration. 
  • Cell wall chitosan is necessary for virulence in the opportunistic pathogen Cryptococcus neoformans. 
  • Cell-Compatible, Site-Specific Covalent Modification of Hydrogel Scaffolds Enables User-Defined Control over Cell-Material Interactions. 
  • Cell-Type-Specific Optical Recording of Membrane Voltage Dynamics in Freely Moving Mice. 
  • Cell-autonomous activation of the PI3-kinase pathway initiates endometrial cancer from adult uterine epithelium. 
  • Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency. 
  • Cell-based gene therapy for repair of critical size defects in the rat fibula. 
  • Cell-based vaccines for the stimulation of immunity to metastatic cancers. 
  • Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption. 
  • Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. 
  • Cell-dependent posttranslational processing and secretion of recombinant mouse renin-2. 
  • Cell-mediated cytotoxicity of murine cytomegalovirus-infected target cells allows for release of residual infectious virus. 
  • Cell-programmed nutrient partitioning in the tumour microenvironment. 
  • Cell-specific constraints to the lateral diffusion of a membrane glycoprotein. 
  • Cell-surface co-receptors: emerging roles in signaling and human disease. 
  • Cell-type specific regulation of gene expression by simian virus 40 T antigens. 
  • Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2, and RB phosphorylation, resembling events of early cell-cycle traverse. 
  • Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease. 
  • Cells treated with TAP-2 antisense oligonucleotides are potent antigen-presenting cells in vitro and in vivo. 
  • Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling. 
  • Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis. 
  • Cellular and functional defects in a mouse model of heart failure. 
  • Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. 
  • Cellular and viral splicing factors can modify the splicing pattern of CFTR transcripts carrying splicing mutations. 
  • Cellular crosstalk regulates the aqueous humor outflow pathway and provides new targets for glaucoma therapies. 
  • Cellular cytoskeleton dynamics modulates non-viral gene delivery through RhoGTPases 
  • Cellular determinants of reduced adaptability of the aging brain: neurotransmitter utilization and cell signaling responses after MDMA lesions. 
  • Cellular engineering for the treatment of metabolic disorders: prospects for therapy in diabetes. 
  • Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen. 
  • Cellular immune response to cryptic epitopes during therapeutic gene transfer. 
  • Cellular immune responses in neonates. 
  • Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. 
  • Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene. 
  • Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis. 
  • Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors. 
  • Cellular requirements for anti-DNA production induced in mice by immunization with bacterial DNA. 
  • Cellular response to phase-separated blends of tyrosine-derived polycarbonates. 
  • Cellular serine proteinase induces chemotaxis by complement activation. 
  • Cellular stress signaling activates type-I IFN response through FOXO3-regulated lamin posttranslational modification. 
  • Central and peripheral effects of insulin/IGF-1 signaling in aging and cancer: antidiabetic drugs as geroprotectors and anticarcinogens. 
  • Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells. 
  • Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation. 
  • Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen. 
  • Centrifugal migration of mesenchymal cells in embryonic lung. 
  • Ceramide mediates nanovesicle shedding and cell death in response to phosphatidylinositol ether lipid analogs and perifosine. 
  • Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice. 
  • Cerebral Cavernous Malformations Develop Through Clonal Expansion of Mutant Endothelial Cells. 
  • Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican. 
  • Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction. 
  • Cerium Oxide Nanoparticles: A Potential Medical Countermeasure to Mitigate Radiation-Induced Lung Injury in CBA/J Mice. 
  • Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. 
  • Cervical Vagus Nerve Stimulation Improves Neurologic Outcome After Cardiac Arrest in Mice by Attenuating Oxidative Stress and Excessive Autophagy. 
  • Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection. 
  • Cessation of biomechanical stretch model of C2C12 cells models myocyte atrophy and anaplerotic changes in metabolism using non-targeted metabolomics analysis. 
  • ChREBP regulates fructose-induced glucose production independently of insulin signaling. 
  • Challenges of comparative expression profiling studies of complex diseases: mouse models of myocardial hypertrophy. Focus on "Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy". 
  • Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model. 
  • Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging. 
  • Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice. 
  • Changes in magnetization transfer MRI correlate with spreading depression-induced astroglial reactivity and increased protein expression in mice. 
  • Changes in the behaviour of teratocarcinoma cells cultivated in vitro. 
  • Changes in the binding of "fast"-form alpha 2-macroglobulin to 3T3-L1 cells after differentiation to adipocytes. 
  • Changes in the dendritic branching of adult mammalian neurones revealed by repeated imaging in situ. 
  • Changes in the rate of laminin and entactin synthesis in F9 embryonal carcinoma cells treated with retinoic acid and cyclic amp. 
  • Characterisation of systemic dissemination of nonreplicating adenoviral vectors from tumours in local gene delivery. 
  • Characteristics of Vibration that Alter Cardiovascular Parameters in Mice. 
  • Characteristics of sequential activity in networks with temporally asymmetric Hebbian learning. 
  • Characterization and Functional Phenotyping of Renal Immune Cells via Flow Cytometry. 
  • Characterization and comparison of commercially available antinuclear antibody kits using single pattern index sera. 
  • Characterization and expression of a rice RAD23 gene. 
  • Characterization and expression of the complementary DNA encoding rat histidine decarboxylase. 
  • Characterization and identification of measurable endpoints in a mouse model featuring age-related retinal pathologies: a platform to test therapies. 
  • Characterization and idiotypic analysis of an anti-RNP monoclonal antibody. 
  • Characterization and initial demonstration of in vivo efficacy of a novel heat-activated metalloenediyne anti-cancer agent. 
  • Characterization and optimization of RGD-containing silk blends to support osteoblastic differentiation. 
  • Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans. 
  • Characterization and solubilization of pyrrole-imidazole polyamide aggregates. 
  • Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors. 
  • Characterization of 67 kD laminin receptor, a protein whose gene is overexpressed on treatment of cells with anti-benzo[a]pyrene-7,8-diol-9,10-epoxide. 
  • Characterization of Adipogenic Activity of House Dust Extracts and Semi-Volatile Indoor Contaminants in 3T3-L1 Cells. 
  • Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling. 
  • Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation. 
  • Characterization of Fatty Acid Binding Protein 7 (FABP7) in the Murine Retina. 
  • Characterization of Langerin-expressing dendritic cell subsets in the normal cornea. 
  • Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout background. 
  • Characterization of PDK2 activity against protein kinase B gamma. 
  • Characterization of Per- and Polyfluorinated Alkyl Substances Present in Commercial Anti-fog Products and Their In Vitro Adipogenic Activity. 
  • Characterization of Plasmodium liver stage inhibition by halofuginone. 
  • Characterization of a CD6 ligand(s) expressed on human- and murine-derived cell lines and murine lymphoid tissues. 
  • Characterization of a CNS cell line, CAD, in which morphological differentiation is initiated by serum deprivation. 
  • Characterization of a castrate-resistant prostate cancer xenograft derived from a patient of West African ancestry. 
  • Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. 
  • Characterization of a human prostate adenocarcinoma cell line (DU 145) as a monolayer culture and as a solid tumor in athymic mice. 
  • Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation. 
  • Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies. 
  • Characterization of a novel human corneal endothelial antigen. 
  • Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. 
  • Characterization of a recovery global cerebral ischemia model in the mouse. 
  • Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion. 
  • Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope. 
  • Characterization of alpha 2-macroglobulin-plasmin complexes: complete subunit cleavage alters receptor recognition in vivo and in vitro. 
  • Characterization of an oxaliplatin sensitivity predictor in a preclinical murine model of colorectal cancer. 
  • Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. 
  • Characterization of angiotensin II-receptor subtypes in podocytes. 
  • Characterization of antibodies to canine renal renin. Studies of interspecies homology of renin using antibodies as probe. 
  • Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models. 
  • Characterization of basal pseudopod-like processes in ileal and colonic PYY cells. 
  • Characterization of cDNA encoding mouse DNA repair protein O6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in Escherichia coli. 
  • Characterization of cardiovascular injury in mice following partial-heart irradiation with clinically relevant dose and fractionation. 
  • Characterization of cord blood natural killer and lymphokine activated killer lymphocytes following ex vivo cellular engineering. 
  • Characterization of cytotoxic cells generated from in vitro cultures of murine bone marrow cells. 
  • Characterization of delta opioid receptors in lung cancer using a novel nonpeptidic ligand. 
  • Characterization of effector T cells in dry eye disease. 
  • Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted mice. 
  • Characterization of functional human alpha 2-macroglobulin half-molecules isolated by limited reduction with dithiothreitol. 
  • Characterization of glomerular thromboxane receptors in murine lupus nephritis. 
  • Characterization of human CD7 transgenic mice. 
  • Characterization of insulin-like growth factor-binding protein-related proteins (IGFBP-rPs) 1, 2, and 3 in human prostate epithelial cells: potential roles for IGFBP-rP1 and 2 in senescence of the prostatic epithelium. 
  • Characterization of intraocular immunopathology following intracameral inoculation with alloantigen. 
  • Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins. 
  • Characterization of liver GSD IX γ2 pathophysiology in a novel Phkg2-/- mouse model. 
  • Characterization of moesin in the sea urchin Lytechinus variegatus: redistribution to the plasma membrane following fertilization is inhibited by cytochalasin B. 
  • Characterization of monoclonal antibodies with specificity for DNA and the synthetic polypeptide antigen (T,G)-A-L. 
  • Characterization of murine peritoneal macrophage receptors for fibrin(ogen) degradation products. 
  • Characterization of nanoprobe uptake in single cells: spatial and temporal tracking via SERS labeling and modulation of surface charge. 
  • Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells. 
  • Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line. 
  • Characterization of potential precursor populations in the mouse olfactory epithelium using immunocytochemistry and autoradiography. 
  • Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model. 
  • Characterization of senescence- and apoptosis-dependent forms of terminin as derived from a precursor found in replicating and nonreplicating cells. 
  • Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene. 
  • Characterization of subtle brain abnormalities in a mouse model of Hedgehog pathway antagonist-induced cleft lip and palate. 
  • Characterization of the axon initial segment of mice substantia nigra dopaminergic neurons. 
  • Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. 
  • Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature. 
  • Characterization of the effects of endotoxin on macrophage tumor cell killing. 
  • Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts. 
  • Characterization of the immune response to the major glycoprotein (gp 71) of Friend leukemia virus. I. Response in BALB/c mice. 
  • Characterization of the immune response to the major glycoprotein (gp71) of Friend leukemia virus. II. Response in C57BL/6 mice. 
  • Characterization of the immune response to the major glycoprotein (gp71) of Friend leukemia virus. III. Influence on endogenous MuLV-mediated pathogenesis. 
  • Characterization of the insulinotropic potency of polyunsaturated fatty acids. 
  • Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft. 
  • Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. 
  • Characterization of the mouse SPARC/osteonectin gene. Intron/exon organization and an unusual promoter region. 
  • Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues. 
  • Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal. 
  • Characterization of the role of the amino-terminal proline in the enzymatic activity catalyzed by macrophage migration inhibitory factor. 
  • Characterization of the serum In(Lu)-related antigen: identification of a serum protein related to erythrocyte p80. 
  • Characterization of the tissue regression process in the uterus of older mice as apoptotic by the presence of Tp30, an isoform of terminin. 
  • Characterization of the trans-activation properties of equine herpesvirus 1 EICP0 protein. 
  • Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia. 
  • Characterization of three restricted specificity monoclonal antibodies raised against the human glioma cell line D-54 MG. 
  • Characterization of tumor-specific cytotoxic effector cells with a novel CD3-/Thy-1+ phenotype. 
  • Characterizing the Potency and Impact of Carbon Ion Therapy in a Primary Mouse Model of Soft Tissue Sarcoma. 
  • Chelation, formulation, encapsulation, retention, and in vivo biodistribution of hydrophobic nanoparticles labelled with ⁵⁷ Co-porphyrin: Oleylamine ensures stable chelation of cobalt in nanoparticles that accumulate in tumors. 
  • Chemerin suppresses hepatocellular carcinoma metastasis through CMKLR1-PTEN-Akt axis. 
  • Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages. 
  • Chemical and structural modifications of alpha 2-macroglobulin: effects on receptor binding and endocytosis studied in an in vivo model. 
  • Chemical denervation with botulinum neurotoxin a improves the surgical manipulation of the muscle-tendon unit: an experimental study in an animal model. 
  • Chemical evidence for early but unsustained growth in the obstructed mouse kidney. 
  • Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. 
  • Chemical interrogation of the malaria kinome. 
  • Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis. 
  • Chemical modification and site-directed mutagenesis of conserved HXXH and PP-loop motif arginines and histidines in the murine bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase. 
  • Chemical pancreatectomy: an unconventional approach to preventing autodigestion in pancreatitis. 
  • Chemical sintering generates uniform porous hyaluronic acid hydrogels 
  • Chemical skin carcinogenesis is prevented in mice by the induced expression of a TGF-beta related transgene. 
  • Chemical structure of carbamoylating groups and their relationship to bone marrow toxicity and antiglioma activity of bifunctionally alkylating and carbamoylating nitrosoureas. 
  • Chemico-genetic discovery of astrocytic control of inhibition in vivo. 
  • Chemogenetics-mediated acute inhibition of excitatory neuronal activity improves stroke outcome. 
  • Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2. 
  • Chemokine receptor CCR5 promotes leukocyte trafficking to the brain and survival in West Nile virus infection. 
  • Chemokines and B-cell homing to follicles. 
  • Chemoprevention of pancreatic cancer: ready for the clinic? 
  • Chemotactic factor and P15E-related chemotaxis inhibitor in human melanoma cell lines with different macrophage content and tumorigenicity in nude mice. 
  • Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer. 
  • Chemotherapy and radiation therapy of human medulloblastoma in athymic nude mice. 
  • Chemotherapy of subcutaneous and intracranial human medulloblastoma xenografts in athymic nude mice. 
  • Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer. 
  • Chicken calmodulin promoter activity in proliferating and differentiated cells. 
  • Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo. 
  • Childhood cerebellar tumours mirror conserved fetal transcriptional programs. 
  • Chimeric Sindbis/eastern equine encephalitis vaccine candidates are highly attenuated and immunogenic in mice. 
  • Chimeric alphavirus vaccine candidates for chikungunya. 
  • Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent. 
  • Chimeric spike mRNA vaccines protect against Sarbecovirus challenge in mice. 
  • Chitosan Biosynthesis and Virulence in the Human Fungal Pathogen Cryptococcus gattii. 
  • Chitosan Derivatives Active against Multidrug-Resistant Bacteria and Pathogenic Fungi: In Vivo Evaluation as Topical Antimicrobials. 
  • Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10. 
  • Chlamydia trachomatis Infection Leads to Defined Alterations to the Lipid Droplet Proteome in Epithelial Cells. 
  • Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells. 
  • Chloroform inhalation exposure conditions necessary to initiate liver toxicity in female B6C3F1 mice. 
  • Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation. 
  • Chloroquine, quinine and quinidine inhibit calcium release from macrophage intracellular stores by blocking inositol 1,4,5-trisphosphate binding to its receptor. 
  • Cholecystokinin is not a peripheral satiety signal in the dog. 
  • Cholera toxin acts as a potent adjuvant for the induction of cytotoxic T-lymphocyte responses with non-replicating antigens. 
  • Cholera toxin and cell growth: role of membrane gangliosides. 
  • Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. 
  • Choline attenuates inflammatory hyperalgesia activating nitric oxide/cGMP/ATP-sensitive potassium channels pathway. 
  • Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus. 
  • Cholinergic agonists inhibit HMGB1 release and improve survival in experimental sepsis. 
  • Cholinergic augmentation of insulin release requires ankyrin-B. 
  • Cholinergic neurons constitutively engage the ISR for dopamine modulation and skill learning in mice. 
  • Cholinergic regulatory lymphocytes re-establish neuromodulation of innate immune responses in sepsis. 
  • Chondrocyte-Specific RUNX2 Overexpression Accelerates Post-traumatic Osteoarthritis Progression in Adult Mice. 
  • Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. 
  • Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice. 
  • Chordin and noggin promote organizing centers of forebrain development in the mouse. 
  • Chordin is a modifier of tbx1 for the craniofacial malformations of 22q11 deletion syndrome phenotypes in mouse. 
  • Chromatin Remodeling of Colorectal Cancer Liver Metastasis is Mediated by an HGF-PU.1-DPP4 Axis. 
  • Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci. 
  • Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. 
  • Chromium (VI) at plausible drinking water concentrations is not genotoxic in the in vivo bone marrow micronucleus or liver unscheduled DNA synthesis assays. 
  • Chromium(VI) induces p53-dependent apoptosis in diploid human lung and mouse dermal fibroblasts. 
  • Chromosomal assignment of the murine Gi alpha and Gs alpha genes. Implications for the obese mouse. 
  • Chromosomal assignments of the genes coding for human types II, III, and IV collagen: a dispersed gene family. 
  • Chromosomal composition of malignant human gliomas through serial subcutaneous transplantation in athymic mice. 
  • Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. 
  • Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10. 
  • Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA. 
  • Chromosomal organization of adrenergic receptor genes. 
  • Chromosome mapping of human cell surface molecules: monoclonal anti-human lymphocyte antibodies 4F2, A3D8, and A1G3 define antigens controlled by different regions of chromosome 11. 
  • Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation. 
  • Chronic activation of the kinase IKKβ impairs T cell function and survival. 
  • Chronic aspiration shifts the immune response from Th1 to Th2 in a murine model of asthma. 
  • Chronic aspiration shifts the immune response from adaptive immunity to innate immunity in a murine model of asthma. 
  • Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity. 
  • Chronic caloric restriction maintains a youthful phosphoproteome in aged skeletal muscle. 
  • Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. 
  • Chronic dry eye disease is principally mediated by effector memory Th17 cells. 
  • Chronic elevation of calmodulin in the ventricles of transgenic mice increases the autonomous activity of calmodulin-dependent protein kinase II, which regulates atrial natriuretic factor gene expression. 
  • Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation. 
  • Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice. 
  • Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice. 
  • Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions. 
  • Chronic in vivo multi-circuit neurophysiological recordings in mice. 
  • Chronic inhibition of cyclic GMP phosphodiesterase 5A prevents and reverses cardiac hypertrophy. 
  • Chronic intermittent hypoxia induces NMDA receptor-dependent plasticity and suppresses nitric oxide signaling in the mouse hypothalamic paraventricular nucleus. 
  • Chronic liver disease and impaired hepatic glycogen metabolism in argininosuccinate lyase deficiency. 
  • Chronic loss of inhibition in piriform cortex following brief, daily optogenetic stimulation. 
  • Chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens. 
  • Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function. 
  • Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration. 
  • Chronic phospholamban-sarcoplasmic reticulum calcium ATPase interaction is the critical calcium cycling defect in dilated cardiomyopathy. 
  • Chronic rejection of mouse kidney allografts. 
  • Chronic suppression of heart-failure progression by a pseudophosphorylated mutant of phospholamban via in vivo cardiac rAAV gene delivery. 
  • Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice. 
  • Chronic wound repair and healing in older adults: current status and future research. 
  • Chronopharmacology of strychnine and allylglycine in the mouse. 
  • Cigarette smoke-related hydroquinone induces filamentous actin reorganization and heat shock protein 27 phosphorylation through p38 and extracellular signal-regulated kinase 1/2 in retinal pigment epithelium: implications for age-related macular degeneration. 
  • Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD. 
  • Cilia loss sensitizes cells to transformation by activating the mevalonate pathway. 
  • Ciliary neurotrophic factor receptor alpha mRNA in NB41A3 neuroblastoma cells: regulation by cAMP. 
  • Ciliated epithelial cell lifespan in the mouse trachea and lung. 
  • Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. 
  • Circadian rhythms of activity and drinking in mice lacking angiotensin II 1A receptors. 
  • Circuit and synaptic organization of forebrain-to-midbrain pathways that promote and suppress vocalization. 
  • Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder. 
  • Circular RNA circEsyt2 regulates vascular smooth muscle cell remodeling via splicing regulation. 
  • Circular RNAs are abundant, conserved, and associated with ALU repeats. 
  • Circular transcripts of the testis-determining gene Sry in adult mouse testis. 
  • Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors. 
  • Circulating Levels of Soluble Dipeptidyl Peptidase-4 Are Dissociated from Inflammation and Induced by Enzymatic DPP4 Inhibition. 
  • Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo. 
  • Circulating mitochondria in organ donors promote allograft rejection. 
  • Circulating tumor cells exit circulation while maintaining multicellularity, augmenting metastatic potential. 
  • Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor. 
  • Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice. 
  • Cisplatin, BCNU, cyclophosphamide, and prednisone in multiple myeloma. 
  • Citrullination of fibronectin alters integrin clustering and focal adhesion stability promoting stromal cell invasion. 
  • Cl- and K+ transport in human biliary cell lines. 
  • Clara cells attenuate the inflammatory response through regulation of macrophage behavior. 
  • Class I restricted CTL recognition of a soluble protein delivered by liposomes containing lipophilic polylysines. 
  • Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. 
  • Classical Dendritic Cells Mediate Hypertension by Promoting Renal Oxidative Stress and Fluid Retention. 
  • Classical conditioning drives learned reward prediction signals in climbing fibers across the lateral cerebellum. 
  • Classically conditioned enhancement of hyperinsulinemia in the ob/ob mouse. 
  • Classically conditioned hyperglycemia in the obese mouse. 
  • Clearance and binding of native and defucosylated lactoferrin. 
  • Clearance and binding of two electrophoretic "fast" forms of human alpha 2-macroglobulin. 
  • Clearance and distribution of recombinant murine gamma-interferon in mice. 
  • Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2. 
  • Clinical isolates of measles virus use CD46 as a cellular receptor. 
  • Clinical prospects for neural grafting therapy for hippocampal lesions and epilepsy. 
  • Clinical-pathological correlations of BAV and the attendant thoracic aortopathies. Part 2: Pluridisciplinary perspective on their genetic and molecular origins. 
  • Clonal Analysis of the Neonatal Mouse Heart using Nearest Neighbor Modeling. 
  • Clonal contributions of small numbers of retrovirally marked hematopoietic stem cells engrafted in unirradiated neonatal W/Wv mice. 
  • Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities. 
  • Cloned endothelium derived from autoimmune vascular disease retain structural and functional characteristics of normal endothelial cells. 
  • Cloned mice have an obese phenotype not transmitted to their offspring. 
  • Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor. 
  • Cloning and characterization of SLP3: a novel member of the stomatin family expressed by olfactory receptor neurons. 
  • Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. 
  • Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. 
  • Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. 
  • Cloning and characterization of three new murine genes encoding short homologues of RNase P RNA. 
  • Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. 
  • Cloning genes that encode inducible forms of P-450. 
  • Cloning of B cells from autoimmune MRL-lpr/lpr and MRL.xid mice. 
  • Cloning of a complementary DNA encoding a new mouse B lymphocyte differentiation antigen, homologous to the human B1 (CD20) antigen, and localization of the gene to chromosome 19. 
  • Cloning of cDNA and analysis of the gene for mouse angiotensin II type 2 receptor. 
  • Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway. 
  • Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper discs. I. A description of the technique and of methods for the analysis of colonies. 
  • Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper discs. II. Paratope frequencies within the mitogen-selected repertoire. 
  • Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper disks: phenotypic and genotypic analysis of B cell colonies. 
  • Cloning of murine splenic T lymphocytes and natural killer (NK) cells on filter paper discs: detection of a novel NK/T phenotype. 
  • Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene. 
  • Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. 
  • Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. 
  • Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family. 
  • Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase. 
  • Close genetic and physical linkage between the murine haemopoietic growth factor genes GM-CSF and Multi-CSF (IL3). 
  • Closing the iron gate. 
  • Club cells surviving influenza A virus infection induce temporary nonspecific antiviral immunity. 
  • Clustered Arg–Gly–Asp peptides enhances tumor targeting of nonviral vectors 
  • Clustered cancer cells show a distinct adhesion behavior from single cell form under physiological shear conditions. 
  • Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV. 
  • Clustering of voltage-sensitive sodium channels on axons is independent of direct Schwann cell contact in the dystrophic mouse. 
  • Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome. 
  • Co-assembling peptides as defined matrices for endothelial cells. 
  • Co-delivery of antigen and IL-12 by Venezuelan equine encephalitis virus replicon particles enhances antigen-specific immune responses and antitumor effects. 
  • Co-expression of vimentin and cytokeratins in parietal endoderm cells of early mouse embryo. 
  • Co-immunization with multimeric scaffolds and DNA rapidly induces potent autologous HIV-1 neutralizing antibodies and CD8+ T cells. 
  • Co-opted JNK/SAPK signaling in Wnt/beta-catenin-induced tumorigenesis. 
  • Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis. 
  • Coactivation of NF-κB and Notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion. 
  • Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy. 
  • Coadministration of IL-12 or IL-10 expression cassettes drives immune responses toward a Th1 phenotype. 
  • Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. 
  • Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens. 
  • Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. 
  • Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. 
  • Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: in vitro expression and immune responses in DNA-vaccinated mice. 
  • Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach. 
  • Coevolution of the major histocompatibility complex and the t-complex in the mouse. I. Generation and maintenance of high complementarity associations. 
  • Coevolution of the major histocompatibility complex and the t-complex in the mouse. II. Modification of response to sharing of histocompatibility antigens. 
  • Cold Plasma Discharge Tube Enhances Antitumoral Efficacy of Temozolomide. 
  • Cold-induced brain edema in mice. Involvement of extracellular superoxide dismutase and nitric oxide. 
  • Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation. 
  • Collagen fibril diameters in arteries of mice. A comparison of manual and computer-aided morphometric analyses. 
  • Collagen type-V is a danger signal associated with primary graft dysfunction in lung transplantation. 
  • Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis. 
  • Collapsing glomerulopathy: an inflammatory podocytopathy? 
  • Colloidal gold fluorescent microspheres: a new retrograde marker visualized by light and electron microscopy. 
  • Colonial morphology of staphylococci on Memphis agar: phase variation of slime production, resistance to beta-lactam antibiotics, and virulence. 
  • Colonoscopic injection for murine solid cecal cancer model. 
  • Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation. 
  • Colorectal cancer models for novel drug discovery. 
  • Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. 
  • Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4, tumor necrosis factor, and transforming growth factor-beta production. 
  • Combination gene therapy for liver metastasis of colon carcinoma in vivo. 
  • Combination immunotherapy and radiotherapy causes an abscopal treatment response in a mouse model of castration resistant prostate cancer. 
  • Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation. 
  • Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. 
  • Combination of Rad001 (everolimus) and propachlor synergistically induces apoptosis through enhanced autophagy in prostate cancer cells. 
  • Combination of ultrasound-based mechanical disruption of tumor with immune checkpoint blockade modifies tumor microenvironment and augments systemic antitumor immunity. 
  • Combination testing (Stage 2) of the Anti-IGF-1 receptor antibody IMC-A12 with rapamycin by the pediatric preclinical testing program. 
  • Combination testing of cediranib (AZD2171) against childhood cancer models by the pediatric preclinical testing program. 
  • Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. 
  • Combination therapy with potent PI3K and MAPK inhibitors overcomes adaptive kinome resistance to single agents in preclinical models of glioblastoma. 
  • Combination treatment of murine tumors by adenovirus-mediated local B7/IL12 immunotherapy and radiotherapy. 
  • Combination versus single agent therapy in effecting complete therapeutic response in human bladder cancer: analysis of cisplatin and/or 5-fluorouracil in an in vivo survival model. 
  • Combinatorial Single-Cell Analyses of Granulocyte-Monocyte Progenitor Heterogeneity Reveals an Early Uni-potent Neutrophil Progenitor. 
  • Combined Atomic Force Microscope and Volumetric Light Sheet System for Correlative Force and Fluorescence Mechanobiology Studies. 
  • Combined MEK and JAK inhibition abrogates murine myeloproliferative neoplasm. 
  • Combined Supplementation with Vitamin B-6 and Curcumin is Superior to Either Agent Alone in Suppressing Obesity-Promoted Colorectal Tumorigenesis in Mice. 
  • Combined activity of amphotericin B and 5-fluorocytosine against Cryptococcus neoformans in vitro and in vivo in mice. 
  • Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial-lysosomal axis and alleviates autophagic blockage in Pompe disease. 
  • Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. 
  • Combined deletion of Glut1 and Glut3 impairs lung adenocarcinoma growth. 
  • Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansion. 
  • Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging. 
  • Combined iDISCO and CUBIC tissue clearing and lightsheet microscopy for in toto analysis of the adult mouse ovary†. 
  • Combined kinase inhibitors of MEK1/2 and either PI3K or PDGFR are efficacious in intracranial triple-negative breast cancer. 
  • Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice. 
  • Combining PARP-1 inhibition and radiation in Ewing sarcoma results in lethal DNA damage. 
  • Commensal Bacteria Regulate Gene Expression and Differentiation in Vertebrate Olfactory Systems Through Transcription Factor REST. 
  • Comments about Joint Modeling of Cluster Size and Binary and Continuous Subunit-Specific Outcomes. 
  • Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. Activated intrarenal renin-angiotensin system is correlated with high blood pressure in humans. 
  • Commissioning a small-field biological irradiator using point, 2D, and 3D dosimetry techniques. 
  • Commitment to cell death is signaled by the appearance of a terminin protein of 30 kDa. 
  • Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. 
  • Common human ANK2 variant confers in vivo arrhythmia phenotypes. 
  • Common promoter elements in odorant and vomeronasal receptor genes. 
  • Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10. 
  • Comparative Genomic Analysis of the Pheromone Receptor Class 1 Family (V1R) Reveals Extreme Complexity in Mouse Lemurs (Genus, Microcebus) and a Chromosomal Hotspot across Mammals. 
  • Comparative analysis of antigen loading strategies of dendritic cells for tumor immunotherapy. 
  • Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse. 
  • Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells. 
  • Comparative cellular analysis of motor cortex in human, marmoset and mouse. 
  • Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours. 
  • Comparative efficacy evaluation of dicationic carbazole compounds, nitazoxanide, and paromomycin against Cryptosporidium parvum infections in a neonatal mouse model. 
  • Comparative evaluation of a new magnetic bead-based DNA extraction method from fecal samples for downstream next-generation 16S rRNA gene sequencing. 
  • Comparative genomics search for losses of long-established genes on the human lineage. 
  • Comparative immunogenicity of HIV-1 gp160, gp140 and gp120 expressed by live attenuated newcastle disease virus vector. 
  • Comparative incorporation of P32 into lung phosphatidyl choline in mammals with different metabolic and pulmonary morphologic characteristics. 
  • Comparative localization of glioma-reactive monoclonal antibodies in vivo in an athymic mouse human glioma xenograft model. 
  • Comparative localization of murine monoclonal antibody Me1-14 F(ab')2 fragment and whole IgG2a in human glioma xenografts. 
  • Comparative pathogenesis of clinical and nonclinical isolates of Saccharomyces cerevisiae. 
  • Comparative stereology of mouse atria. 
  • Comparative stereology of the lizard and frog myocardium. 
  • Comparative stereology of the mouse and finch left ventricle. 
  • Comparative tissue distribution in mice of the alpha-emitter 211At and 131I as labels of a monoclonal antibody and F(ab')2 fragment. 
  • Comparative toxicity of C60 aggregates toward mammalian cells: role of tetrahydrofuran (THF) decomposition. 
  • Comparative vibration levels perceived among species in a laboratory animal facility. 
  • Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker. 
  • Comparing in vivo pump-probe and multiphoton fluorescence microscopy of melanoma and pigmented lesions. 
  • Comparison between midline and lateral fluid percussion injury in mice reveals prolonged but divergent cortical neuroinflammation. 
  • Comparison of 4D-microSPECT and microCT for murine cardiac function. 
  • Comparison of [18 F]fluorocholine and [18 F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer. 
  • Comparison of animal models for head and neck cancer cachexia. 
  • Comparison of fecal biota from specific pathogen free and feral mice. 
  • Comparison of in vitro and in vivo differentiation of myeloblastic leukemia of the RFM/Un mouse. 
  • Comparison of in vivo efficacy and mechanism of action of antimurine monoclonal antibodies directed against TCR alpha beta (H57-597) and CD3 (145-2C11). 
  • Comparison of intradermal and intramuscular delivery followed by in vivo electroporation of SIV Env DNA in macaques. 
  • Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration. 
  • Comparison of multiple vaccine vectors in a single heterologous prime-boost trial. 
  • Comparison of pleural responses of rats and hamsters to subchronic inhalation of refractory ceramic fibers. 
  • Comparison of the Hypoxia PET Tracer (18)F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models. 
  • Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. 
  • Comparison of the effects of IL-1 alpha and TNF-alpha on phagocyte accumulation and murine antibacterial immunity. 
  • Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI. 
  • Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo. 
  • Comparison of the genomes of the wild-type French viscerotropic strain of yellow fever virus with its vaccine derivative French neurotropic vaccine. 
  • Comparison of the role of esterases in the differential age-related sensitivity to chlorpyrifos and methamidophos. 
  • Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans. 
  • Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice. 
  • Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents. 
  • Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections. 
  • Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice. 
  • Compensatory renal growth after unilateral ureteral obstruction. 
  • Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI. 
  • Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling. 
  • Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. 
  • Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation. 
  • Complement activation contributes to perioperative neurocognitive disorders in mice. 
  • Complement and CD4+ T cells drive context-specific corneal sensory neuropathy. 
  • Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement. 
  • Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses. 
  • Complement-Dependent Synaptic Uptake and Cognitive Decline after Stroke and Reperfusion Therapy. 
  • Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response. 
  • Complementary codes for odor identity and intensity in olfactory cortex. 
  • Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction. 
  • Complete and unidirectional conversion of human embryonic stem cells to trophoblast by BMP4. 
  • Complete correction of hyperphenylalaninemia following liver-directed, recombinant AAV2/8 vector-mediated gene therapy in murine phenylketonuria. 
  • Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV. 
  • Complex Antigens Drive Permissive Clonal Selection in Germinal Centers. 
  • Complex Role for E-Prostanoid 4 Receptors in Hypertension. 
  • Complexes between serpins and inactive proteinases are not thermodynamically stable but are recognized by serpin receptors. 
  • Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. 
  • Components of a new gene family of ferroxidases involved in virulence are functionally specialized in fungal dimorphism. 
  • Compound haploinsufficiency of Dok2 and Dusp4 promotes lung tumorigenesis. 
  • Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. 
  • Comprehensive analysis of commercially available mouse antichicken monoclonal antibodies for cross-reactivity with peripheral blood leukocytes from commercial turkeys. 
  • Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies. 
  • Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts. 
  • Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+. 
  • Compromised HOXA5 function can limit p53 expression in human breast tumours. 
  • Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene. 
  • Computational modelling of perivascular-niche dynamics for the optimization of treatment schedules for glioblastoma. 
  • Computational models of cancer cell transport through the microcirculation. 
  • Computational multiscale toxicodynamic modeling of silver and carbon nanoparticle effects on mouse lung function. 
  • Computational tools for understanding sequence variability in recombination signals. 
  • Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent. 
  • Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch. 
  • Computer-aided Discovery of a New Nav1.7 Inhibitor for Treatment of Pain and Itch. 
  • Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice. 
  • Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells. 
  • Concepts and challenges in cancer risk prediction for the space radiation environment. 
  • Concerted morphogenesis of genital ridges and nephric ducts in the mouse captured through whole-embryo imaging. 
  • Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide. 
  • Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. 
  • Concomitant control of mechanical properties and degradation in resorbable elastomer-like materials using stereochemistry and stoichiometry for soft tissue engineering. 
  • Concurrent administration of coenzyme Q10 and alpha-tocopherol improves learning in aged mice. 
  • Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro. 
  • Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence. 
  • Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice. 
  • Conditional antibody expression to avoid central B cell deletion in humanized HIV-1 vaccine mouse models. 
  • Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. 
  • Conditional deletion of TrkC does not modify limbic epileptogenesis. 
  • Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior. 
  • Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation. 
  • Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model. 
  • Conditional gene silencing in mammalian cells mediated by a stress-inducible promoter. 
  • Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles. 
  • Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. 
  • Conditional telomerase induction causes proliferation of hair follicle stem cells. 
  • Conditions for an in vitro culture of murine mixed hematopoietic colonies and their putative cellular origin. 
  • Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro. 
  • Conformable hierarchically engineered polymeric micromeshes enabling combinatorial therapies in brain tumours. 
  • Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. 
  • Congenital neuro-ophthalmic toxoplasmosis in the mouse. 
  • Congenital polycystic kidney disease. Genetically transmitted infantile polycystic kidney disease in C57BL/6J mice. 
  • Congenital toxoplasmic retinochoroiditis in a mouse model. 
  • Conjugate of Doxorubicin to Albumin-Binding Peptide Outperforms Aldoxorubicin. 
  • Connectome Smoothing via Low-Rank Approximations. 
  • Connexin 36 and rod bipolar cell independent rod pathways drive retinal ganglion cells and optokinetic reflexes. 
  • Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. 
  • Consensus Recommendation for Mouse Models of Ocular Hypertension to Study Aqueous Humor Outflow and Its Mechanisms. 
  • Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment. 
  • Consequences of intra-articular bleeding in haemophilia: science to clinical practice and beyond. 
  • Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. 
  • Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptors. 
  • Conserved action of β-catenin during female fate determination in the red-eared slider turtle. 
  • Conserved and divergent expression dynamics during early patterning of the telencephalon in mouse and chick embryos. 
  • Conserved cryptic recombination signals in Vkappa gene segments are cleaved in small pre-B cells. 
  • Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals. 
  • Constitutive Stat3 activation alters behavior of hair follicle stem and progenitor cell populations. 
  • Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence. 
  • Constitutive activation of the aromatic hydrocarbon receptor. 
  • Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. 
  • Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. 
  • Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. 
  • Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. 
  • Constructing an adult orofacial premotor atlas in Allen mouse CCF. 
  • Construction and preclinical characterization of Fc-mGITRL for the immunotherapy of cancer. 
  • Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. 
  • Construction of low-variability litters of preweaning mice. 
  • Construction of modular circuits in the mammalian brain. 
  • Construction, imaging, and analysis of FRET-based tension sensors in living cells. 
  • Contained indirect viable-cell membrane immunofluorescence microassay for surface antigen analysis of cells infected with hazardous viruses. 
  • Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note. 
  • Content and Performance of the MiniMUGA Genotyping Array: A New Tool To Improve Rigor and Reproducibility in Mouse Research. 
  • Context-dependent effects of whole-genome duplication during mammary tumor recurrence. 
  • Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. 
  • Continuous Culture of Mouse Primary B Lymphocytes by Forced Expression of Bach2. 
  • Continuous administration of the three thrombospondin-1 type 1 repeats recombinant protein improves the potency of therapy in an orthotopic human pancreatic cancer model. 
  • Contrast dependence and differential contributions from somatostatin- and parvalbumin-expressing neurons to spatial integration in mouse V1. 
  • Contrast-enhanced in vivo magnetic resonance microscopy of the mouse brain enabled by noninvasive opening of the blood-brain barrier with ultrasound. 
  • Contrasting response of lung parenchymal cells to instilled TNF alpha and IFN gamma: the inducibility of specific cell ICAM-1 in vivo. 
  • Contribution of 3CD Region to the Virulence of Enterovirus 71. 
  • Contribution of IL-13 to early exocrinopathy in Id3-/- mice. 
  • Contribution of Polycomb group proteins to olfactory basal stem cell self-renewal in a novel c-KIT+ culture model and in vivo. 
  • Contribution of Sensory Encoding to Measured Bias. 
  • Contribution of a 28-kilodalton membrane protein to the virulence of Haemophilus influenzae. 
  • Contribution of adipogenesis to healthy adipose tissue expansion in obesity. 
  • Contribution of mast cells to bacterial clearance and their proliferation during experimental cystitis induced by type 1 fimbriated E. coli. 
  • Contribution of the VH11 gene family to mitogen-responsive B cell repertoire in C57BL/6 mice. 
  • Contributions of CD8 T cells to the pathogenesis of mouse adenovirus type 1 respiratory infection. 
  • Contributions of E1A to mouse adenovirus type 1 pathogenesis following intranasal inoculation. 
  • Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice. 
  • Contributions of endothelial and neuronal nitric oxide synthases to cerebrovascular responses to hyperoxia. 
  • Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage. 
  • Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects. 
  • Control elements within the PWS/AS imprinting box and their function in the imprinting process. 
  • Control idiotope expression by monoclonal anti-idiotope antibodies. 
  • Control of CD4 gene expression: connecting signals to outcomes in T cell development. 
  • Control of IFN-alphaA by CD73: implications for mucosal inflammation. 
  • Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases). 
  • Control of Intestinal Inflammation, Colitis-Associated Tumorigenesis, and Macrophage Polarization by Fibrinogen-Like Protein 2. 
  • Control of PD-L1 Expression by Oncogenic Activation of the AKT-mTOR Pathway in Non-Small Cell Lung Cancer. 
  • Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. 
  • Control of RhoA methylation by carboxylesterase I. 
  • Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. 
  • Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1. 
  • Control of embryonic lung branching morphogenesis by the Rho activator, cytotoxic necrotizing factor 1. 
  • Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. 
  • Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J mice. 
  • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. 
  • Control of idiotope expression by monoclonal anti-idiotope and idiotope-bearing antibody. 
  • Control of liver and brain aromatic amino-acid metabolism by phenylalanine hydroxylase. 
  • Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. 
  • Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. 
  • Control of morphology and virulence by ADP-ribosylation factors (Arf) in Mucor circinelloides. 
  • Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice. 
  • Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. 
  • Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR. 
  • Controlled Lengthwise Assembly of Helical Peptide Nanofibers to Modulate CD8⁺ T-Cell Responses. 
  • Controlled Release of Vancomycin and Tigecycline from an Orthopaedic Implant Coating Prevents Staphylococcus aureus Infection in an Open Fracture Animal Model. 
  • Controlled release of etoricoxib from poly(ester urea) films for post-operative pain management. 
  • Controlled release of simvastatin from in situ forming hydrogel triggers bone formation in MC3T3-E1 cells. 
  • Controlling cancer-induced inflammation with a nucleic acid scavenger prevents lung metastasis in murine models of breast cancer. 
  • Controlling for activity-dependent genes and behavioral states is critical for determining brain relationships within and across species. 
  • Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling. 
  • Convergence of bladder and colon sensory innervation occurs at the primary afferent level. 
  • Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes. 
  • Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. 
  • Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica. 
  • Convergent differential regulation of SLIT-ROBO axon guidance genes in the brains of vocal learners. 
  • Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing. 
  • Convergent effects on cell signaling mechanisms mediate the actions of different neurobehavioral teratogens: alterations in cholinergic regulation of protein kinase C in chick and avian models. 
  • Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity 
  • Conversion of diploidy to haploidy. 
  • Conversion of effector CD4+ T cells to a CD8+ MHC II-recognizing lineage. 
  • Cooperation among multiple transcription factors is required for access to minimal T-cell receptor alpha-enhancer chromatin in vivo. 
  • Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3. 
  • Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. 
  • Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport. 
  • Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. 
  • Coordinate regulation of mRNAs from multiple calmodulin genes during myoblast differentiation in vitro. 
  • Coordinate regulation of the alpha(2)-macroglobulin signaling receptor and the low density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor by insulin. 
  • Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions. 
  • Coordinated genome-wide modifications within proximal promoter cis-regulatory elements during vertebrate evolution 
  • Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole. 
  • Copper Chelation as Targeted Therapy in a Mouse Model of Oncogenic BRAF-Driven Papillary Thyroid Cancer. 
  • Copper is required for oncogenic BRAF signalling and tumorigenesis. 
  • Cord blood and bone marrow transplantation in inherited metabolic diseases: scientific basis, current status and future directions. 
  • Cordon-bleu is a conserved gene involved in neural tube formation. 
  • Cordon-bleu is an actin nucleation factor and controls neuronal morphology. 
  • Core N-Glycan Structures Are Critical for the Pathogenicity of Cryptococcus neoformans by Modulating Host Cell Death. 
  • Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model. 
  • Corneal penetration of topical and subconjunctival bevacizumab. 
  • Corpora amylacea are associated with tau burden and cognitive status in Alzheimer's disease. 
  • Correcting the limited view in optical-resolution photoacoustic microscopy. 
  • Correction of aberrant splicing of the cystic fibrosis transmembrane conductance regulator (CFTR) gene by antisense oligonucleotides. 
  • Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases. 
  • Correction of glycogen storage disease type II by an adeno-associated virus vector containing a muscle-specific promoter. 
  • Correction of multiple striated muscles in murine Pompe disease through adeno-associated virus-mediated gene therapy. 
  • Correction of proliferative responses in purine nucleoside phosphorylase (PNP)-deficient T lymphocytes by retroviral-mediated PNP gene transfer and expression. 
  • Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease. 
  • Correlating notch signaling with thymocyte maturation. 
  • Correlation between axonal morphologies and synaptic input kinetics of interneurons from mouse visual cortex. 
  • Correlation of DNA fragmentation and chromatin condensation in apoptotic nuclei of the Ser 6 mouse retina. 
  • Correlation of expression of bombesin-like peptides and receptors with growth inhibition by an anti-bombesin antibody in small-cell lung cancer cell lines. 
  • Correlation of the tight junction-like distribution of Claudin-1 to the cellular tropism of hepatitis C virus. 
  • Correlation of total and interstrand DNA adducts in tumor and kidney with antitumor efficacies and differential nephrotoxicities of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin. 
  • Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell. 
  • Correspondence re: Geradts J, Wilentz RE, Roberts H. Immunohistochemical detection of the alternate ink4a-encoded tumor suppressor protein p14(arf) in archival human cancers and cell lines using commercial antibodies: correlation with p16(ink4a) expression. Mod pathol 2001;14:1162-68. 
  • Cortical control of affective networks. 
  • Cortical glutamic acid decarboxylase 67 deficiency results in lower cannabinoid 1 receptor messenger RNA expression: implications for schizophrenia. 
  • Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. 
  • Cortical interneurons that specialize in disinhibitory control. 
  • Cortical plasticity induced by inhibitory neuron transplantation. 
  • Cortical representations of olfactory input by trans-synaptic tracing. 
  • Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency. 
  • Cortico-cortical projections in mouse visual cortex are functionally target specific. 
  • Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. 
  • Corticorelin acetate, a synthetic corticotropin-releasing factor with preclinical antitumor activity, alone and with bevacizumab, against human brain tumor models. 
  • Costimulation Blockade Resistant Rejection. 
  • Costimulation of adenylyl cyclase and phospholipase C by a mutant alpha 1B-adrenergic receptor transgene promotes malignant transformation of thyroid follicular cells. 
  • Costimulation of γδTCR and TLR7/8 promotes Vδ2 T-cell antitumor activity by modulating mTOR pathway and APC function. 
  • Costimulator dependence of lymphokine secretion by naive and activated CD4+ T lymphocytes from TCR transgenic mice. 
  • Cotransfection of heme oxygenase-1 prevents the acute inflammation elicited by a second adenovirus. 
  • Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa. 
  • Coupled myovascular expansion directs cardiac growth and regeneration. 
  • Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. 
  • Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. 
  • Covalent complexes of antigen and alpha(2)-macroglobulin: evidence for dramatically-increased immunogenicity. 
  • Covalent immobilization of stem cell factor and stromal derived factor 1α for in vitro culture of hematopoietic progenitor cells. 
  • Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels. 
  • Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors, distinct from CrmB, that binds TNF but not LT alpha. 
  • Cowpox virus induces interleukin-10 both in vitro and in vivo. 
  • Coxsackievirus A2 Leads to Heart Injury in a Neonatal Mouse Model. 
  • Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone. 
  • Cre-dependent adeno-associated virus preparation and delivery for labeling neurons in the mouse brain. 
  • Creatine and cyclocreatine attenuate MPTP neurotoxicity. 
  • Creatine kinase activity as an indicator of unopposed estrogen action in the mouse uterus associated with anti-progesterone treatment. 
  • Creatine kinase overexpression improves ATP kinetics and contractile function in postischemic myocardium. 
  • Creatine kinase-mediated improvement of function in failing mouse hearts provides causal evidence the failing heart is energy starved. 
  • Creation of human tumour cells with defined genetic elements. 
  • Creation of versatile cloning platforms for transgene expression and dCas9-based epigenome editing. 
  • Critical role for mouse marginal zone B cells in PF4/heparin antibody production. 
  • Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction. 
  • Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. 
  • Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity. 
  • Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. 
  • Critical role of TNF-α in cerebral aneurysm formation and progression to rupture. 
  • Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA. 
  • Critical roles of RasGRP1 for invariant NKT cell development. 
  • Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses. 
  • Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma. 
  • Cross-Reactive Immunity Among Flaviviruses. 
  • Cross-Reactivity to Kynureninase Tolerizes B Cells That Express the HIV-1 Broadly Neutralizing Antibody 2F5. 
  • Cross-reacting antigens on L5178Y cells which serve as targets for cytotoxic T-lymphocyte lysis during establishment of the tumor dormant state. 
  • Cross-reactions of virally and chemically induced mouse sarcomas: surface expression of a common viral antigen. 
  • Cross-reactive coronavirus antibodies with diverse epitope specificities and Fc effector functions. 
  • Cross-reactive monoclonal antibodies to multiple HIV-1 subtype and SIVcpz envelope glycoproteins. 
  • Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer. 
  • Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease. 
  • Cross-subtype T-cell immune responses induced by a human immunodeficiency virus type 1 group m consensus env immunogen. 
  • Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice. 
  • Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern 
  • Crosstransplantation of kidneys in normal and Hyp mice. Evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect. 
  • Crucial role for the VWF A1 domain in binding to type IV collagen. 
  • Crucial role of copper in detection of metal-coordinating odorants. 
  • Cryo-electron microscopy of biological samples. 
  • Cryopreservation of neurospheres derived from human glioblastoma multiforme. 
  • Cryptococcal cell morphology affects host cell interactions and pathogenicity. 
  • Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli. 
  • Cryptococcosis. 
  • Cryptococcus gattii VGIII isolates causing infections in HIV/AIDS patients in Southern California: identification of the local environmental source as arboreal. 
  • Cryptococcus neoformans Cda1 and Its Chitin Deacetylase Activity Are Required for Fungal Pathogenesis. 
  • Cryptococcus neoformans Chitin Synthase 3 Plays a Critical Role in Dampening Host Inflammatory Responses. 
  • Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37 degrees C and in vivo. 
  • Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. 
  • Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses. 
  • Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence. 
  • Cryptococcus neoformans gene expression during murine macrophage infection. 
  • Cryptococcus neoformans gene involved in mammalian pathogenesis identified by a Caenorhabditis elegans progeny-based approach. 
  • Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis. 
  • Cryptococcus neoformans is resistant to surfactant protein A mediated host defense mechanisms. 
  • Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence. 
  • Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth. 
  • Cryptococcus neoformans phosphoinositide-dependent kinase 1 (PDK1) ortholog is required for stress tolerance and survival in murine phagocytes. 
  • Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host. 
  • Cryptococcus neoformans resists to drastic conditions by switching to viable but non-culturable cell phenotype. 
  • Cryptococcus neoformans {alpha} strains preferentially disseminate to the central nervous system during coinfection. 
  • Cryptococcus neoformans: a sugar-coated killer with designer genes. 
  • Cryptosporidium-malnutrition interactions: mucosal disruption, cytokines, and TLR signaling in a weaned murine model. 
  • Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition. 
  • Culture of endodermal stem/progenitor cells of the mouse tongue. 
  • Culture-enriched community profiling improves resolution of the vertebrate gut microbiota. 
  • Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC. 
  • Curcumin Ameliorates Heat-Induced Injury through NADPH Oxidase-Dependent Redox Signaling and Mitochondrial Preservation in C2C12 Myoblasts and Mouse Skeletal Muscle. 
  • Current knowledge of the platelet glycoprotein IIb/IIIa receptor antagonists for the treatment of coronary artery disease. 
  • Cutaneous wound healing is impaired in hemophilia B. 
  • Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors 
  • Cutting Edge: Elevated Glycolytic Metabolism Limits the Formation of Memory CD8+ T Cells in Early Life. 
  • Cutting Edge: Localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development. 
  • Cutting Edge: c-Maf Is Required for Regulatory T Cells To Adopt RORγt+ and Follicular Phenotypes. 
  • Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. 
  • Cutting edge: C3d functions as a molecular adjuvant in the absence of CD21/35 expression. 
  • Cutting edge: CD91-independent cross-presentation of GRP94(gp96)-associated peptides. 
  • Cutting edge: Cytosolic bacterial DNA activates the inflammasome via Aim2. 
  • Cutting edge: Mouse NAIP1 detects the type III secretion system needle protein. 
  • Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo. 
  • Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses. 
  • Cutting edge: Role of osteopontin and integrin αv in T cell-mediated anti-inflammatory responses in endotoxemia. 
  • Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK. 
  • Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. 
  • Cutting edge: critical role of intracellular osteopontin in antifungal innate immune responses. 
  • Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. 
  • Cutting edge: hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation. 
  • Cutting edge: trimolecular interaction of TCR with MHC class II and bacterial superantigen shows a similar affinity to MHC:peptide ligands. 
  • Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. 
  • Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. 
  • Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans. 
  • Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells. 
  • Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation. 
  • Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior. 
  • Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. 
  • Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. 
  • Cyclin-dependent kinase 4 expression alters the number of keratinocyte stem cells in the mouse hair follicle. 
  • Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits growth of a broad spectrum of cancer cells derived from solid tumors. 
  • Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits the replication of human herpes viruses. 
  • Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning. 
  • Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. 
  • Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor). 
  • Cyclophosphamide treatment used to manipulate the immune response for the production of monoclonal antibodies. 
  • Cyclosporin A inhibits inositol 1,4,5-trisphosphate binding to its receptors and release of calcium from intracellular stores in peritoneal macrophages. 
  • Cyclosporin-A increases synthesis of 1,25-dihydroxyvitamin D3 in the rat and mouse. 
  • Cyclosporine inhibition of CH series murine B-cell lymphomas. 
  • Cyclosporine inhibition of a murine B cell lymphoma. 
  • Cyr61 mediates hepatocyte growth factor-dependent tumor cell growth, migration, and Akt activation. 
  • Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly. 
  • Cysteine-tailed class I-binding peptides bind to CpG adjuvant and enhance primary CTL responses. 
  • Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice. 
  • Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. 
  • Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas. 
  • Cytoarchitecture of the mouse brain by high resolution diffusion magnetic resonance imaging. 
  • Cytochrome P1-450 structural gene in mouse, rat, and rabbit: differences in DNA methylation and developmental expression of mRNA. 
  • Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. 
  • Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans. 
  • Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin. 
  • Cytogenetic changes induced by 1-(N1-methylhydrazinomethyl)-N-isopropyl benzamide in Ehrlich ascites tumor cells. 
  • Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3. 
  • Cytokine deposition alters leukocyte morphology and initial recruitment of monocytes and γδT cells after corneal injury. 
  • Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation. 
  • Cytokine expression in vivo during murine herpetic stromal keratitis. Effect of protective antibody therapy. 
  • Cytokine requirements for induction of systemic and mucosal CTL after nasal immunization. 
  • Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells. 
  • Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. 
  • Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. 
  • Cytokine transcriptional events during helper T cell subset differentiation. 
  • Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes. 
  • Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization. 
  • Cytokines in murine lyme carditis: Th1 cytokine expression follows expression of proinflammatory cytokines in a susceptible mouse strain. 
  • Cytomegalovirus as an immunomodulator across the lifespan. 
  • Cytoplasmic LPS activates caspase-11: implications in TLR4-independent endotoxic shock. 
  • Cytoplasmic flagellin activates caspase-1 and secretion of interleukin 1beta via Ipaf. 
  • Cytoprotection by somatostatin of normal and malignant clonogenic cells against the in vitro cytotoxicity of bischloroethylnitrosourea (BCNU). 
  • Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation. 
  • Cytosine methylation and suppression of O6-methylguanine-DNA methyltransferase expression in human rhabdomyosarcoma cell lines and xenografts. 
  • Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS. 
  • Cytosolic branched chain aminotransferase (BCATc) mRNA is up-regulated in restricted brain areas of BDNF transgenic mice. 
  • Cytosolic phospholipase A(2) activity associated with nuclei is not inhibited by arachidonyl trifluoromethyl ketone in macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin. 
  • Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis. 
  • Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. 
  • Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate. 
  • Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo. 
  • Cytotoxicity of alpha-particle-emitting astatine-211-labelled antibody in tumour spheroids: no effect of hyperthermia. 
  • D-Amino acid peptide residualizing agents bearing N-hydroxysuccinimido- and maleimido-functional groups and their application for trastuzumab radioiodination. 
  • D6.1, a murine antimelanoma monoclonal antibody from congenitally athymic nude mice immunized with purified melanoma tumor-associated antigen. 
  • DDR2 upregulation confers ferroptosis susceptibility of recurrent breast tumors through the Hippo pathway. 
  • DEK is a poly(ADP-ribose) acceptor in apoptosis and mediates resistance to genotoxic stress. 
  • DEK over-expression promotes mitotic defects and micronucleus formation. 
  • DEK regulates hematopoietic stem engraftment and progenitor cell proliferation. 
  • DGK α and ζ Activities Control TH1 and TH17 Cell Differentiation. 
  • DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. 
  • DMT1 expression is increased in the lungs of hypotransferrinemic mice. 
  • DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States. 
  • DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin. 
  • DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach 
  • DNA delivery from matrix metalloproteinase degradable poly (ethylene glycol) hydrogels to mouse cloned mesenchymal stem cells 
  • DNA fragments from F9 PyEC mutants increase expression of heterologous genes in transfected F9 cells. 
  • DNA methylation atlas of the mouse brain at single-cell resolution. 
  • DNA mismatch repair is required for the host innate response and controls cellular fate after influenza virus infection. 
  • DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype. 
  • DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells. 
  • DNA transfection of macaque and murine respiratory tissue is greatly enhanced by use of a nuclease inhibitor. 
  • DNA vaccination by intradermal electroporation induces long-lasting immune responses in rhesus macaques. 
  • DNA vaccine molecular adjuvants SP-D-BAFF and SP-D-APRIL enhance anti-gp120 immune response and increase HIV-1 neutralizing antibody titers. 
  • DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation. 
  • DNA-remethylation around a STAT5-binding enhancer in the alphaS1-casein promoter is associated with abrupt shutdown of alphaS1-casein synthesis during acute mastitis. 
  • DOK2 inhibits EGFR-mutated lung adenocarcinoma. 
  • DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. 
  • DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain. 
  • DVT: a new era in anticoagulant therapy. 
  • DYT-TOR1A subcellular proteomics reveals selective vulnerability of the nuclear proteome to cell stress. 
  • Dabigatran abrogates brain endothelial cell permeability in response to thrombin. 
  • Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis. 
  • Damage- and pathogen-associated molecular patterns play differential roles in late mortality after critical illness. 
  • Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity. 
  • Data analysis: evaluation of nanoscale contrast agent enhanced CT scan to differentiate between benign and malignant lung cancer in mouse model. 
  • Data and animal management software for large-scale phenotype screening. 
  • Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. 
  • De novo TRIM8 variants impair its protein localization to nuclear bodies and cause developmental delay, epilepsy, and focal segmental glomerulosclerosis. 
  • De novo adipocyte differentiation from Pdgfrβ+ preadipocytes protects against pathologic visceral adipose expansion in obesity. 
  • Death-associated protein kinase 1 promotes growth of p53-mutant cancers. 
  • Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells. 
  • Deciphering the tête-à-tête between the microbiota and the immune system. 
  • Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. 
  • Decoding the olfactory map through targeted transcriptomics links murine olfactory receptors to glomeruli. 
  • Deconstructing B cell tolerance to basement membranes. 
  • Deconstructing behavioral neuropharmacology with cellular specificity. 
  • Deconstructing the genesis of animal form. 
  • Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity. 
  • Decreased S -Nitrosylation of Tissue Transglutaminase Contributes to Age-Related Increases in Vascular Stiffness 
  • Decreased Th17 and antigen-specific humoral responses in CX₃ CR1-deficient mice in the collagen-induced arthritis model. 
  • Decreased aquaporin expression leads to increased resistance to apoptosis in hepatocellular carcinoma. 
  • Decreased autophagy and fuel switching occur in a senescent hepatic cell model system. 
  • Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain. 
  • Decreased cochlear DNA receptor staining in MRL.MpJ-Fas(lpr) autoimmune mice with hearing loss. 
  • Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid. 
  • Decreased fibronectin expression in Met/HGF-mediated tumorigenesis. 
  • Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen. 
  • Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. 
  • Decreased tumorigenesis in mice with a Kras point mutation at C118. 
  • Deep-tissue anatomical imaging of mice using carbon nanotube fluorophores in the second near-infrared window. 
  • Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe. 
  • Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. 
  • Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media. 
  • Defective T cell development and function in the absence of Abelson kinases. 
  • Defective antitumor responses in CX3CR1-deficient mice. 
  • Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression. 
  • Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. 
  • Defective glucose-stimulated insulin release from perifused islets of C57BL/6J mice. 
  • Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse. 
  • Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. 
  • Defective mesonephric cell migration is associated with abnormal testis cord development in C57BL/6J XY(Mus domesticus) mice. 
  • Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells. 
  • Defective prolactin signaling impairs pancreatic β-cell development during the perinatal period. 
  • Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV. 
  • Defective survival and activation of thymocytes in transgenic mice expressing a catalytically inactive form of Ca2+/calmodulin-dependent protein kinase IV. 
  • Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition. 
  • Defects in mononuclear phagocytic system (MPS) function in autoimmune MRL-lpr/lpr mice. 
  • Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice. 
  • Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction. 
  • Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice. 
  • Deficiencies in the Fanconi anemia DNA damage response pathway increase sensitivity to HPV-associated head and neck cancer. 
  • Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. 
  • Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice. 
  • Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice. 
  • Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition. 
  • Deficiency of Mucosal-Associated Invariant T Cells in TCRJα18 Germline Knockout Mice. 
  • Deficiency of Shank2 causes mania-like behavior that responds to mood stabilizers. 
  • Deficiency of activation-induced cytidine deaminase in a murine model of ulcerative colitis. 
  • Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy. 
  • Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection. 
  • Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. 
  • Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice. 
  • Deficiency of optineurin enhances osteoclast differentiation by attenuating the NRF2-mediated antioxidant response. 
  • Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. 
  • Deficiency of the placenta- and yolk sac-specific tristetraprolin family member ZFP36L3 identifies likely mRNA targets and an unexpected link to placental iron metabolism. 
  • Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling. 
  • Deficits in passive avoidance and fear behavior following bilateral and unilateral amygdala lesions in mice. 
  • Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice. 
  • Defined conditions for long-term expansion of murine and human alveolar epithelial stem cells in three-dimensional cultures. 
  • Defining Potential Vaccine Targets of Haemophilus ducreyi Trimeric Autotransporter Adhesin DsrA. 
  • Defining Transcription Regulatory Elements in the Human Frataxin Gene: Implications for Gene Therapy. 
  • Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1. 
  • Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody. 
  • Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis. 
  • Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma. 
  • Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement. 
  • Degenerative joint changes following intra-articular fracture are more severe in mice with T cell deficiency. 
  • Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice. 
  • Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus. 
  • Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression. 
  • Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme. 
  • Deletion of Atm in Tumor but not Endothelial Cells Improves Radiation Response in a Primary Mouse Model of Lung Adenocarcinoma. 
  • Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC. 
  • Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse. 
  • Deletion of GSK3β in D2R-expressing neurons reveals distinct roles for β-arrestin signaling in antipsychotic and lithium action. 
  • Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. 
  • Deletion of MLIP (muscle-enriched A-type lamin-interacting protein) leads to cardiac hyperactivation of Akt/mammalian target of rapamycin (mTOR) and impaired cardiac adaptation. 
  • Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. 
  • Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. 
  • Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal. 
  • Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription. 
  • Deletion of a splicing enhancer disrupts PLP1/DM20 ratio and myelin stability. 
  • Deletion of angiotensin II type 2 receptor accelerates adipogenesis in murine mesenchymal stem cells via Wnt10b/beta-catenin signaling. 
  • Deletion of p16 and p15 genes in brain tumors. 
  • Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. 
  • Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. 
  • Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism. 
  • Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia. 
  • Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate. 
  • Deletion of the p16INK4a tumor suppressor and expression of the androgen receptor induce sarcomatoid carcinomas with signet ring cells in the mouse prostate. 
  • Deletion of the phosphatase INPP5E in the murine retina impairs photoreceptor axoneme formation and prevents disc morphogenesis. 
  • Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. 
  • Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. 
  • Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer. 
  • Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers. 
  • Delivery of viral vectors to tumor cells: extracellular transport, systemic distribution, and strategies for improvement. 
  • Delivery rate affects uptake of a fluorescent glucose analog in murine metastatic breast cancer. 
  • Delivery-corrected imaging of fluorescently-labeled glucose reveals distinct metabolic phenotypes in murine breast cancer. 
  • Delta-like 1-Lysine613 regulates notch signaling. 
  • DeltaFosB in brain reward circuits mediates resilience to stress and antidepressant responses. 
  • Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. 
  • Demineralized Murine Skeletal Histology. 
  • Demineralized murine skeletal histology. 
  • Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. 
  • Dendritic Cells Interpret Haptotactic Chemokine Gradients in a Manner Governed by Signal-to-Noise Ratio and Dependent on GRK6. 
  • Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/beta. 
  • Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases. 
  • Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. 
  • Dendritic cell/macrophage precursors capture exogenous antigen for MHC class I presentation by dendritic cells. 
  • Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy. 
  • Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. 
  • Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma. 
  • Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells. 
  • Dendritic epidermal T cells regulate skin antimicrobial barrier function. 
  • Dendritic-NK cell interactions in P. gingivalis-specific responses. 
  • Dengue virus-elicited tryptase induces endothelial permeability and shock. 
  • Dependence of corneal stem/progenitor cells on ocular surface innervation. 
  • Dependence of germinal center B cells on expression of CD21/CD35 for survival. 
  • Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function. 
  • Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells. 
  • Depletion of catalytic and regulatory subunits of protein kinase CK2 by antisense oligonucleotide treatment of neuroblastoma cells. 
  • Depletion of passenger leukocytes from corneal grafts: an effective means of promoting transplant survival? 
  • Depolarization-stimulated cholecystokinin secretion is mediated by L-type calcium channels in STC-1 cells. 
  • Depressed expression of adipocyte beta-adrenergic receptors is a common feature of congenital and diet-induced obesity in rodents. 
  • Depression of macrophage function by a factor produced by neoplasms: a merchanism for abrogation of immune surveillance. 
  • Depression of murine macrophage accumulation by low-molecular-weight derived from spontaneous mammary carcinomas. 
  • Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. 
  • Derivation of a biologically contained replication system for human immunodeficiency virus type 1. 
  • Derivation of chondrogenically-committed cells from human embryonic cells for cartilage tissue regeneration. 
  • Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. 
  • Derivation of therapeutic lung spheroid cells from minimally invasive transbronchial pulmonary biopsies. 
  • Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice. 
  • Description of monoclonal antibody defining an HLA allotypic determinant that includes specificities within the B5 cross-reacting group. 
  • Desensitization of angiotensin receptor function. 
  • Desensitization of the mouse thromboxane A2 receptor (TP) by G protein-coupled receptor kinases (Grks). 
  • Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. 
  • Design and Analysis of Large-Scale Biological Rhythm Studies: A Comparison of Algorithms for Detecting Periodic Signals in Biological Data 
  • Design and characterization of a peptide mimotope of the HIV-1 gp120 bridging sheet. 
  • Design and characterization of microporous hyaluronic acid hydrogels for in vitro gene transfer to mMSCs 
  • Design and validation of a dynamic cell-culture system for bone biology research and exogenous tissue-engineering applications. 
  • Design of a novel small peptide targeted against a tumor-specific receptor. 
  • Design of a superconducting volume coil for magnetic resonance microscopy of the mouse brain. 
  • Design, Synthesis, and Mechanism Study of Benzenesulfonamide-Containing Phenylalanine Derivatives as Novel HIV-1 Capsid Inhibitors with Improved Antiviral Activities. 
  • Designer monotransregulators provide a basis for a transcriptional therapy for de novo endocrine-resistant breast cancer. 
  • Desmin interacts with STIM1 and coordinates Ca2+ signaling in skeletal muscle. 
  • Desmoplakin controls microvilli length but not cell adhesion or keratin organization in the intestinal epithelium. 
  • Desmoplakin: an unexpected regulator of microtubule organization in the epidermis. 
  • Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. 
  • Detailed analysis of gene expression during development of T cell lineages in the thymus. 
  • Detecting and characterizing circular RNAs. 
  • Detection of Ebola virus envelope using monoclonal and polyclonal antibodies in ELISA, surface plasmon resonance and a quartz crystal microbalance immunosensor. 
  • Detection of Escherichia coli enterotoxins in stools. 
  • Detection of Lung Nodules in Micro-CT Imaging Using Deep Learning. 
  • Detection of a transformation-specific glycopeptide in SSV-infected cells. 
  • Detection of acrolein-derived cyclic DNA adducts in human cells by monoclonal antibodies. 
  • Detection of cytosolic bacteria by inflammatory caspases. 
  • Detection of early changes in renal function using 99mTc-MAG3 imaging in a murine model of ischemia-reperfusion injury. 
  • Detection of iron-labeled single cells by MR imaging based on intermolecular double quantum coherences at 14 T. 
  • Detection of metastatic tumors in nude mice: brief communication. 
  • Detection of mouse cytomegalovirus nucleic acid in latently infected mice by in vitro enzymatic amplification. 
  • Detection of murine cytomegalovirus immediate early 1 transcripts in the spleens of latently infected mice. 
  • Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse. 
  • Detection of oncornavirus antigenic activity in human urothelial tissues. 
  • Detection of pathogen-specific antibodies by loop-mediated isothermal amplification. 
  • Detection of the major glycoproteins of Friend leukemia virus (gp71) and the murine mammary tumor virus (gp52) on the surface of mouse cells. 
  • Determinants of PF4/heparin immunogenicity. 
  • Determinants of the source of cytomegalovirus in murine renal allograft recipients. 
  • Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC). 
  • Determination of electric parameters of cell membranes by a dielectrophoresis method. 
  • Determination of estrogen receptor messenger ribonucleic acid (mRNA) and cytochrome P450 aromatase mRNA levels in adipocytes and adipose stromal cells by competitive polymerase chain reaction amplification. 
  • Determination of the functional status of alloreactive T cells by interferon-gamma kinetics. 
  • Determining γδ versus αß T cell development. 
  • Developing an HIV vaccine. 
  • Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion. 
  • Development and Efficacy of an Orally Bioavailable Selective TAK1 Inhibitor for the Treatment of Inflammatory Arthritis. 
  • Development and Evaluation of a Novel Mouse Model of Asphyxial Cardiac Arrest Revealed Severely Impaired Lymphopoiesis After Resuscitation. 
  • Development and Preliminary Evaluation of a Murine Model of Chronic Radiation-Induced Proctitis. 
  • Development and application of basic research techniques in bladder cancer research. 
  • Development and biological evaluation of ⁹⁹mTc-sulfonamide derivatives for in vivo visualization of CA IX as surrogate tumor hypoxia markers. 
  • Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic. 
  • Development and characterization of a monoclonal antibody to human embryonal carcinoma. 
  • Development and distribution of a human B cell subpopulation identified by the HB-4 monoclonal antibody. 
  • Development and preclinical evaluation of an alphavirus replicon particle vaccine for cytomegalovirus. 
  • Development and preclinical evaluation of an alphavirus replicon vaccine for influenza. 
  • Development and use of SIV-based Integrase defective lentiviral vector for immunization. 
  • Development and validation of a cell-based fluorescent method for measuring antibody affinity. 
  • Development of Aggressive Pancreatic Ductal Adenocarcinomas Depends on Granulocyte Colony Stimulating Factor Secretion in Carcinoma Cells. 
  • Development of DNA Vaccine Targeting E6 and E7 Proteins of Human Papillomavirus 16 (HPV16) and HPV18 for Immunotherapy in Combination with Recombinant Vaccinia Boost and PD-1 Antibody. 
  • Development of DX-9065a, a novel direct factor Xa antagonist, in cardiovascular disease. 
  • Development of Novel ¹⁸ F-PET Agents for Tumor Hypoxia Imaging. 
  • Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer. 
  • Development of Saccharomyces cerevisiae as a model pathogen. A system for the genetic identification of gene products required for survival in the mammalian host environment. 
  • Development of a 4-D digital mouse phantom for molecular imaging research. 
  • Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation. 
  • Development of a fluorescence detection system using optical parametric oscillator (OPO) laser excitation for in vivo diagnosis. 
  • Development of a high-efficiency method for gene marking of Dunning prostate cancer cell lines with the enzyme beta-galactosidase. 
  • Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain. 
  • Development of a model of melphalan-induced gastrointestinal toxicity in mice. 
  • Development of a monoclonal antibody specific for serotype 3 rotavirus strains. 
  • Development of a novel adjuvanted nasal vaccine: C48/80 associated with chitosan nanoparticles as a path to enhance mucosal immunity. 
  • Development of a precision medicine pipeline to identify personalized treatments for colorectal cancer. 
  • Development of a recombinant yellow fever vector expressing a HIV clade C founder envelope gp120. 
  • Development of a simplified spinal cord ischemia model in mice. 
  • Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics. 
  • Development of an advanced hyperspectral imaging (HSI) system with applications for cancer detection. 
  • Development of an aerosol model of Cryptococcus reveals humidity as an important factor affecting the viability of Cryptococcus during aerosolization. 
  • Development of bioactive photocrosslinkable fibrous hydrogels. 
  • Development of germ cells in the mouse. 
  • Development of glomerular pattern visualized in the olfactory bulbs of living mice. 
  • Development of iron-containing multiwalled carbon nanotubes for MR-guided laser-induced thermotherapy. 
  • Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice. 
  • Development of pemphigus vulgaris-like lesions in severe combined immunodeficiency disease mice reconstituted with lymphocytes from patients. 
  • Development, validation and characterization of a novel mouse model of Adynamic Bone Disease (ABD). 
  • Development-dependent disappearance of caspase-3 in skeletal muscle is post-transcriptionally regulated. 
  • Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. 
  • Developmental activation of the TCR alpha enhancer requires functional collaboration among proteins bound inside and outside the core enhancer. 
  • Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1. 
  • Developmental and transformation-sensitive expression of the Sparc gene on mouse chromosome 11. 
  • Developmental biology. Another hit for gene targeting. 
  • Developmental biology. Branching takes nerve. 
  • Developmental biology. The making of the ear. 
  • Developmental biology: decisions, decisions! 
  • Developmental defects in mouse embryos lacking N-cadherin. 
  • Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance. 
  • Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. 
  • Developmental expression of glycogenolytic enzymes in rabbit tissues: possible relationship to fetal lung maturation. 
  • Developmental expression of renal angiotensin II receptor genes in the mouse. 
  • Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA. 
  • Developmental onset of enduring long-term potentiation in mouse hippocampus. 
  • Developmental regulation of VDJ recombination by the core fragment of the T cell receptor alpha enhancer. 
  • Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells. 
  • Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs. 
  • Developmental regulation of cytochrome oxidase subunit VIa isoforms in cardiac and skeletal muscle. 
  • Developmental regulation of lymphocyte-specific protein 1 (LSP1) expression in thymus during human T-cell maturation. 
  • Developmental regulation of mouse SPARC (osteonectin) gene expression. 
  • Developmental renin expression in mice with a defective renin-angiotensin system. 
  • Developmental roles of pufferfish Hox clusters and genome evolution in ray-fin fish. 
  • Developmental stage-dependent effects of cardiac fibroblasts on function of stem cell-derived engineered cardiac tissues. 
  • Developmental stratification of the mammary epithelium occurs through symmetry-breaking vertical divisions of apically positioned luminal cells. 
  • Developmentally regulated changes in femoral nerve regeneration in the mouse and rat. 
  • Dexamethasone potentiates in vitro blood-brain barrier recovery after primary blast injury by glucocorticoid receptor-mediated upregulation of ZO-1 tight junction protein. 
  • Dexamethasone-induced immunosuppression: mechanisms and implications for immunotherapy. 
  • Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. 
  • Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase. 
  • Diabetic bladder dysfunction progresses from an overactive to an underactive phenotype in a type-1 diabetic mouse model (Akita female mouse) and is dependent on NLRP3. 
  • Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion. 
  • Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells. 
  • Diabetic nephropathy: of mice and men. 
  • Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis. 
  • Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. 
  • Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. 
  • Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii. 
  • Diacylglycerol kinase ζ deficiency in a non-CD4(+) T-cell compartment leads to increased peanut hypersensitivity. 
  • Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses. 
  • Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. 
  • Diagnostic assay to assist clinical decisions for unclassified severe combined immune deficiency. 
  • Diarrhoea associated with heat-stable enterotoxin-producing strains of Escherichia coli. 
  • Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. 
  • Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes. 
  • Dicationic furans inhibit development of Cryptosporidium parvum in HSD/ICR suckling Swiss mice. 
  • Dicer1 functions as a haploinsufficient tumor suppressor. 
  • Dicistronic polioviruses as expression vectors for foreign genes. 
  • Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms. 
  • Dielectrophoresis and electrorotation of neurospora slime and murine myeloma cells. 
  • Diet Alters Entero-Mammary Signaling to Regulate the Breast Microbiome and Tumorigenesis. 
  • Diet and sex modify exercise and cardiac adaptation in the mouse. 
  • Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice. 
  • Diet-induced obese mice retain endogenous leptin action. 
  • Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. 
  • Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice. 
  • Diet-induced type II diabetes in C57BL/6J mice. 
  • Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling. 
  • Dietary Salt Exacerbates Experimental Colitis. 
  • Dietary Sugars Alter Hepatic Fatty Acid Oxidation via Transcriptional and Post-translational Modifications of Mitochondrial Proteins. 
  • Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. 
  • Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury. 
  • Dietary flavonoid naringenin induces regulatory T cells via an aryl hydrocarbon receptor mediated pathway. 
  • Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα. 
  • Dietary manipulation of serotonergic and dopaminergic function in C57BL/6J mice with amino acid depletion mixtures. 
  • Dietary methionine influences therapy in mouse cancer models and alters human metabolism. 
  • Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress. 
  • Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis. 
  • Dietary ω-3 polyunsaturated fatty acids decrease retinal neovascularization by adipose-endoplasmic reticulum stress reduction to increase adiponectin. 
  • Difference-Frequency Ultrasound Imaging With Non-Linear Contrast. 
  • Differences in V kappa gene utilization and VH CDR3 sequence among anti-DNA from C3H-lpr mice and lupus mice with nephritis. 
  • Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine. 
  • Differences in the Antinociceptive Effects and Binding Properties of Propranolol and Bupranolol Enantiomers. 
  • Differences in the absorption, metabolism and biliary excretion of a diastereomeric pair of alphavbeta3-antagonists in rat: limited role of P-glycoprotein. 
  • Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats. 
  • Different immune cells mediate mechanical pain hypersensitivity in male and female mice. 
  • Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro. 
  • Different presynaptic roles of synapsins at excitatory and inhibitory synapses. 
  • Different roles for matrix metalloproteinase-2 and matrix metalloproteinase-9 in the pathogenesis of cardiac allograft rejection. 
  • Different secretory pathways of renin from mouse cells transfected with the human renin gene. 
  • Differential Cell Susceptibilities to KrasG12D in the Setting of Obstructive Chronic Pancreatitis. 
  • Differential Control of iNKT Cell Effector Lineage Differentiation by the Forkhead Box Protein O1 (Foxo1) Transcription Factor. 
  • Differential Health Effects of Constant versus Intermittent Exposure to Formaldehyde in Mice: Implications for Building Ventilation Strategies. 
  • Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma. 
  • Differential Induction of Immunogenic Cell Death and Interferon Expression in Cancer Cells by Structured ssRNAs. 
  • Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies. 
  • Differential Role of B Cells and IL-17 Versus IFN-γ During Early and Late Rejection of Pig Islet Xenografts in Mice. 
  • Differential Sensitivity to Ethanol-Induced Circadian Rhythm Disruption in Adolescent and Adult Mice. 
  • Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice. 
  • Differential activity-dependent, homeostatic plasticity of two neocortical inhibitory circuits. 
  • Differential anti-inflammatory effects of LPS in susceptible and resistant mouse strains. 
  • Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology. 
  • Differential corticostriatal plasticity during fast and slow motor skill learning in mice. 
  • Differential developmental toxicity of naphthoic acid isomers in medaka (Oryzias latipes) embryos. 
  • Differential dynamics and activity-dependent regulation of alpha- and beta-neurexins at developing GABAergic synapses. 
  • Differential effects of calorie restriction and rapamycin on age-related molecular and functional changes in skeletal muscle. 
  • Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. 
  • Differential effects of fat and sucrose on body composition in A/J and C57BL/6 mice. 
  • Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. 
  • Differential effects of insulin-like growth factor (IGF)-binding protein-3 and its proteolytic fragments on ligand binding, cell surface association, and IGF-I receptor signaling. 
  • Differential effects of toll-like receptor stimulation on mRNA-driven myogenic conversion of human and mouse fibroblasts. 
  • Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. 
  • Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity. 
  • Differential expression of VEGF isoforms in mouse during development and in the adult. 
  • Differential expression of a sialoglycoprotein with an approximate molecular weight of 900,000 on metastatic human colon carcinoma cells growing in culture and in tumor tissues. 
  • Differential expression of genes encoding TGFs beta 1, beta 2, and beta 3 during murine palate formation. 
  • Differential expression of intracellular and secreted osteopontin isoforms by murine macrophages in response to toll-like receptor agonists. 
  • Differential expression of microRNAs among cell populations in the regenerating adult mouse olfactory epithelium. 
  • Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. 
  • Differential expression of p63 isoforms in female reproductive organs. 
  • Differential expression of procollagen genes between mid- and late-gestational fetal fibroblasts. 
  • Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes. 
  • Differential gene expression in mouse sclera during ocular development. 
  • Differential gene expression in the distal tip endoderm of the embryonic mouse lung. 
  • Differential glycemic effects of morphine in diabetic and normal mice. 
  • Differential inflammatory responses of the native left and right ventricle associated with donor heart preservation. 
  • Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. 
  • Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. 
  • Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse. 
  • Differential myocardial gene expression in the development and rescue of murine heart failure. 
  • Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior. 
  • Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation. 
  • Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice. 
  • Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines. 
  • Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. 
  • Differential regulation of calcineurin isoforms in transplant patients: a new look at an old problem. 
  • Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases. 
  • Differential regulation of proteasome function in isoproterenol-induced cardiac hypertrophy. 
  • Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice. 
  • Differential regulation of the PGC family of genes in a mouse model of Staphylococcus aureus sepsis. 
  • Differential requirement for the SAP-Fyn interaction during NK T cell development and function. 
  • Differential requirement of RasGRP1 for γδ T cell development and activation. 
  • Differential requirements for NAIP5 in activation of the NLRC4 inflammasome. 
  • Differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection. 
  • Differential screening of a subtracted cDNA library: a method to search for genes preferentially expressed in multiple tissues. 
  • Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding. 
  • Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion. 
  • Differential susceptibility to acetaminophen-induced liver injury in sub-strains of C57BL/6 mice: 6N versus 6J. 
  • Differential uptake of DNA–poly (ethylenimine) polyplexes in cells cultured on collagen and fibronectin surfaces 
  • Differentiated Daughter Cells Regulate Stem Cell Proliferation and Fate through Intra-tissue Tension. 
  • Differentiation of a catecholaminergic CNS cell line modifies tyrosine hydroxylase transcriptional regulation. 
  • Differentiation of erythroleukemia cells in vitro: properties of chemical inducers. 
  • Differentiation of fetal sertoli cells in the adult testis. 
  • Differentiation of human T lymphocytes. I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation. 
  • Differentiation of mammalian skeletal muscle cells cultured on microcarrier beads in a rotating cell culture system. 
  • Differentiation potential of individual olfactory c-Kit+ progenitors determined via multicolor lineage tracing. 
  • Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. 
  • Diffusion tensor imaging analysis of the brain in the canine model of Krabbe disease. 
  • Diffusion tensor imaging using multiple coils for mouse brain connectomics. 
  • Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. 
  • Digital atlasing and standardization in the mouse brain. 
  • Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. 
  • Dilated cardiomyopathy in transgenic mice expressing a mutant A subunit of protein phosphatase 2A. 
  • Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. 
  • Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways. 
  • Diphenhydramine increases the therapeutic window for platinum drugs by simultaneously sensitizing tumor cells and protecting normal cells. 
  • Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer. 
  • Dipyridamole-cisplatin potentiation: enhanced in vivo cytotoxicity in xenograft models of human testicular and bladder cancers. 
  • Direct Actions of AT1 (Type 1 Angiotensin) Receptors in Cardiomyocytes Do Not Contribute to Cardiac Hypertrophy. 
  • Direct Conversion of Human Pluripotent Stem Cells to Osteoblasts With a Small Molecule. 
  • Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation. 
  • Direct correlation between DNA repair capacity and metastatic potential of K-1735 murine melanoma cells. 
  • Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells. 
  • Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. 
  • Direct in vivo measurement of targeted binding in a human tumor xenograft. 
  • Direct interaction of Gas11 with microtubules: implications for the dynein regulatory complex. 
  • Direct measurement of hypoxia in a xenograft multiple myeloma model by optical-resolution photoacoustic microscopy. 
  • Direct reprogramming of cardiac fibroblasts to cardiomyocytes using microRNAs. 
  • Direct sequencing of the activation peptide and the catalytic domain of the factor IX gene in six species. 
  • Direct visualization of cardiac transcription factories reveals regulatory principles of nuclear architecture during pathological remodeling. 
  • Direct-contact co-culture between smooth muscle and endothelial cells inhibits TNF-alpha-mediated endothelial cell activation. 
  • Directed differentiation and neurite extension of mouse embryonic stem cell on aligned poly(lactide) nanofibers functionalized with YIGSR peptide. 
  • Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo. 
  • Directed in vitro myogenesis of human embryonic stem cells and their in vivo engraftment. 
  • Directed intermixing in multicomponent self-assembling biomaterials. 
  • Directing and Potentiating Stem Cell-Mediated Angiogenesis and Tissue Repair by Cell Surface E-Selectin Coating. 
  • Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six. 
  • Disc1 regulates granule cell migration in the developing hippocampus. 
  • Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells. 
  • Discordant complement systems as a factor in hyperacute xenograft rejection. 
  • Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo. 
  • Discovery and characterization of small molecules that target the GTPase Ral. 
  • Discovery and fine mapping of serum protein loci through transethnic meta-analysis. 
  • Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R). 
  • Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. 
  • Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers. 
  • Discovery of Age-Related Protein Folding Stability Differences in the Mouse Brain Proteome. 
  • Discovery of Druggable Host Factors Critical to Plasmodium Liver-Stage Infection. 
  • Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer. 
  • Discovery of Selective Estrogen Receptor Covalent Antagonists for the Treatment of ERαWT and ERαMUT Breast Cancer. 
  • Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor. 
  • Discovery of a functionally selective ghrelin receptor (GHSR1a) ligand for modulating brain dopamine. 
  • Discovery of a novel Toxoplasma gondii conoid-associated protein important for parasite resistance to reactive nitrogen intermediates. 
  • Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor. 
  • Discovery of biomarker candidates for coronary artery disease from an APOE-knock out mouse model using iTRAQ-based multiplex quantitative proteomics. 
  • Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation. 
  • Discovery of novel targets of quinoline drugs in the human purine binding proteome. 
  • Discovery of protein- and DNA-imperceptible nanoparticle hard coating using gel-based reaction tuning. 
  • Discovery of thiophene inhibitors of polo-like kinase. 
  • Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. 
  • Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. 
  • Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis. 
  • Discs of mammalian rod photoreceptors form through the membrane evagination mechanism. 
  • Disease progression in iridocorneal angle tissues of BMP2-induced ocular hypertensive mice with optical coherence tomography. 
  • Disease-Specific Expression of Conjunctiva Associated Lymphoid Tissue (CALT) in Mouse Models of Dry Eye Disease and Ocular Allergy. 
  • Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. 
  • Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. 
  • Disialoganglioside GD2 in human neuroectodermal tumor cell lines and gliomas. 
  • Disparate adjuvant properties among three formulations of "alum". 
  • Disparity in the kinetics of onset of hypermutation in immunoglobulin heavy and light chains. 
  • Display of cell surface sites for fibronectin assembly is modulated by cell adherence to (1)F3 and C-terminal modules of fibronectin. 
  • Disrupted Blood-Retina Lysophosphatidylcholine Transport Impairs Photoreceptor Health But Not Visual Signal Transduction. 
  • Disrupted Neuroglial Metabolic Coupling after Peripheral Surgery. 
  • Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice. 
  • Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. 
  • Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. 
  • Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. 
  • Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology. 
  • Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. 
  • Disruption of Acetyl-Lysine Turnover in Muscle Mitochondria Promotes Insulin Resistance and Redox Stress without Overt Respiratory Dysfunction. 
  • Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities. 
  • Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. 
  • Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus. 
  • Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice. 
  • Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress. 
  • Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity. 
  • Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. 
  • Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon. 
  • Disruption of STIM1-mediated Ca2+ sensing and energy metabolism in adult skeletal muscle compromises exercise tolerance, proteostasis, and lean mass. 
  • Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis. 
  • Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production. 
  • Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele. 
  • Disruption of diacylglycerol metabolism impairs the induction of T cell anergy. 
  • Disruption of dystroglycan-laminin interactions modulates water uptake by astrocytes. 
  • Disruption of intrathymic CD4-Ia interactions on immature CD4+CD8+ thymocytes results in diminished TCR expression on mature CD8+ T cell progeny. 
  • Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. 
  • Disruption of mindin exacerbates cardiac hypertrophy and fibrosis. 
  • Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary. 
  • Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis. 
  • Disruption of the Ang II type 1 receptor promotes longevity in mice. 
  • Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. 
  • Disruption of the gene encoding the mitogen-regulated translational modulator PHAS-I in mice. 
  • Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. 
  • Disruption of the mouse oestrogen receptor gene: resulting phenotypes and experimental findings. 
  • Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. 
  • Disruption of the β1L Isoform of GABP Reverses Glioblastoma Replicative Immortality in a TERT Promoter Mutation-Dependent Manner. 
  • Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus. 
  • Dissecting the Functional Significance of DNA Polymerase Mutations in Cancer. 
  • Dissecting the in vivo metabolic potential of two human gut acetogens. 
  • Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction. 
  • Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice. 
  • Dissociation between vasospasm and functional improvement in a murine model of subarachnoid hemorrhage. 
  • Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice. 
  • Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. 
  • Distinct CD4+ helper T cells involved in primary and secondary responses to infection. 
  • Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. 
  • Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair. 
  • Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. 
  • Distinct Regulation of Th17 and Th1 Cell Differentiation by Glutaminase-Dependent Metabolism. 
  • Distinct Roles of Glutamine Metabolism in Benign and Malignant Cartilage Tumors With IDH Mutations. 
  • Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors. 
  • Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells. 
  • Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice. 
  • Distinct behavioural and network correlates of two interneuron types in prefrontal cortex. 
  • Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation. 
  • Distinct contracted conformations of the Tcra/Tcrd locus during Tcra and Tcrd recombination. 
  • Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. 
  • Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria. 
  • Distinct electric potentials in soma and neurite membranes. 
  • Distinct function of estrogen receptor α in smooth muscle and fibroblast cells in prostate development. 
  • Distinct functional properties of murine perinatal and adult adipose progenitor subpopulations. 
  • Distinct gene expression phenotypes of cells lacking Rb and Rb family members. 
  • Distinct gene expression profiles in adult mouse heart following targeted MAP kinase activation. 
  • Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. 
  • Distinct granuloma responses in C57BL/6J and BALB/cByJ mice in response to pristane. 
  • Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34. 
  • Distinct maturation profiles of perisomatic and dendritic targeting GABAergic interneurons in the mouse primary visual cortex during the critical period of ocular dominance plasticity. 
  • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. 
  • Distinct mouse coronary anatomy and myocardial infarction consequent to ligation. 
  • Distinct nuclear proteins competing for an overlapping sequence of cyclic adenosine monophosphate and negative regulatory elements regulate tissue-specific mouse renin gene expression. 
  • Distinct patterns of glycosylation of colligin, a collagen-binding glycoprotein, and SPARC (osteonectin), a secreted Ca2+-binding glycoprotein. Evidence for the localisation of colligin in the endoplasmic reticulum. 
  • Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding. 
  • Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator. 
  • Distinct properties of cell-type-specific and shared transcription factor binding sites. 
  • Distinct recruitment of feedforward and recurrent pathways across higher-order areas of mouse visual cortex. 
  • Distinct requirements for Ras oncogenesis in human versus mouse cells. 
  • Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse. 
  • Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. 
  • Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia. 
  • Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. 
  • Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways. 
  • Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis. 
  • Distinct stress responses of two functional laccases in Cryptococcus neoformans are revealed in the absence of the thiol-specific antioxidant Tsa1. 
  • Distinctions in the specificity of E2F function revealed by gene expression signatures. 
  • Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest. 
  • Distinctive patterns of hyperplasia in transgenic mice with mouse mammary tumor virus transforming growth factor-alpha. Characterization of mammary gland and skin proliferations. 
  • Distribution of amyloid precursor protein and amyloid-beta in ocular hypertensive C57BL/6 mouse eyes. 
  • Distribution of binding sites for thromboxane A2 in the mouse kidney. 
  • Distribution of expression of 2AR (osteopontin) in the embryonic mouse inner ear revealed by in situ hybridisation. 
  • Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium. 
  • Distribution of, and immune response to, chicken anti-alpha Gal immunoglobulin Y antibodies in wild-type and alpha Gal knockout mice. 
  • Disulfide bond requirements for active Wnt ligands. 
  • Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. 
  • Diurnal torpidity in the California pocket mouse. 
  • Diurnal variations in the toxicity and tissue levels of spermidine in mice. 
  • Divalent cation activation of galactosyltransferase in native mammary Golgi vesicles. 
  • Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. 
  • Divergent functions of angiotensin II receptor isoforms in the brain. 
  • Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium. 
  • Divergent regulation of functionally distinct γ-tubulin complexes during differentiation. 
  • Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. 
  • Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad. 
  • Diverse endogenous light chains contribute to basement membrane reactivity in nonautoimmune mice transgenic for an anti-laminin Ig heavy chain. 
  • Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. 
  • Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms. 
  • Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses. 
  • Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. 
  • Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control. 
  • Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization. 
  • Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth. 
  • Do Adipocytes Emerge from Mural Progenitors? 
  • Do Surface Porosity and Pore Size Influence Mechanical Properties and Cellular Response to PEEK? 
  • Do germinal centers have a role in the generation of lymphomas? 
  • Docetaxel enhances tumor radioresponse in vivo. 
  • Does the intestinal microflora synthesize pyrroloquinoline quinone? 
  • Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes. 
  • Dominant-negative androgen receptor inhibition of intracrine androgen-dependent growth of castration-recurrent prostate cancer. 
  • Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu. 
  • Donor Allospecific CD44high Central Memory T Cells Have Decreased Ability to Mediate Graft-vs.-Host Disease. 
  • Donor apoptotic cell-based therapy for effective inhibition of donor-specific memory T and B cells to promote long-term allograft survival in allosensitized recipients. 
  • Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease. 
  • Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation. 
  • Donor-specific CD8+ Foxp3+ T cells protect skin allografts and facilitate induction of conventional CD4+ Foxp3+ regulatory T cells. 
  • Dopamine and α-synuclein dysfunction in Smad3 null mice. 
  • Dopamine levels modulate the updating of tastant values. 
  • Dopamine mediates vagal modulation of the immune system by electroacupuncture. 
  • Dopamine neuronal transport kinetics and effects of amphetamine. 
  • Dopamine suppresses osteoclast differentiation via cAMP/PKA/CREB pathway. 
  • Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA Is Conveyed through Wide-Field Amacrine Cells. 
  • Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease. 
  • Dopaminergic Control of Inflammation and Glycemia in Sepsis and Diabetes. 
  • Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. 
  • Dopaminergic control of sleep-wake states. 
  • Dopaminergic neurodegeneration induced by Parkinson's disease-linked G2019S LRRK2 is dependent on kinase and GTPase activity. 
  • Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. 
  • Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone. 
  • Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 
  • Dosage-dependent requirements of Magoh for cortical interneuron generation and survival. 
  • Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice. 
  • Dose-dependent expression of claudin-5 is a modifying factor in schizophrenia. 
  • Dosimetry and radiographic analysis of 131I-labeled anti-tenascin 81C6 murine monoclonal antibody in newly diagnosed patients with malignant gliomas: a phase II study. 
  • Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets. 
  • Double-illumination photoacoustic microscopy. 
  • Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. 
  • Down regulation of macrophage mannose/N-acetylglucosamine receptors by elevated glucose concentrations. 
  • Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. 
  • Down-regulation of MHC class I antigen presentation by HCMV; lessons for tumor immunology. 
  • Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells. 
  • Down-regulation of statin, a nonproliferation-specific nuclear protein, and up-regulation of c-myc after initiation of programmed cell death in mouse fibroblasts. 
  • Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation. 
  • Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation. 
  • Downregulation of T cell receptor expression by CD8(+) lymphocytes in kidney allografts. 
  • Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction. 
  • Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion. 
  • Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo. 
  • Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides. 
  • Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia. 
  • Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma. 
  • Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia. 
  • Drebrin attenuates atherosclerosis by limiting smooth muscle cell transdifferentiation. 
  • Drebrin, an actin-binding protein, is required for lens morphogenesis and growth. 
  • Driving an improved CAR for cancer immunotherapy. 
  • Dromedary camel nanobodies broadly neutralize SARS-CoV-2 variants. 
  • Drug targeting using thermally responsive polymers and local hyperthermia. 
  • Drug-Resistant Epimutants Exhibit Organ-Specific Stability and Induction during Murine Infections Caused by the Human Fungal Pathogen Mucor circinelloides. 
  • Drugs derived from cannabinoids. 2. Basic esters of nitrogen and carbocyclic analogs. 
  • Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs. 
  • Dual Metronomic Chemotherapy with Nab-Paclitaxel and Topotecan Has Potent Antiangiogenic Activity in Ovarian Cancer. 
  • Dual Role of Epidermal Growth Factor Receptor in Liver Injury and Regeneration after Acetaminophen Overdose in Mice. 
  • Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo. 
  • Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model. 
  • Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants. 
  • Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. 
  • Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. 
  • Dual role of the exocyst in AMPA receptor targeting and insertion into the postsynaptic membrane. 
  • Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy. 
  • Dual source hybrid spectral micro-CT using an energy-integrating and a photon-counting detector. 
  • Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence. 
  • Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy. 
  • Dual-axis illumination for virtually augmenting the detection view of optical-resolution photoacoustic microscopy 
  • Dual-energy computed tomography imaging of atherosclerotic plaques in a mouse model using a liposomal-iodine nanoparticle contrast agent. 
  • Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study. 
  • Dual-energy micro-CT of the rodent lung. 
  • Dual-energy micro-computed tomography imaging of radiation-induced vascular changes in primary mouse sarcomas. 
  • Dual-mode IVUS transducer for image-guided brain therapy: preliminary experiments. 
  • Dual-targeted hybrid nanoparticles of synergistic drugs for treating lung metastases of triple negative breast cancer in mice. 
  • Dual-wavelength ratiometric fluorescence measurement of the membrane dipole potential. 
  • Duality of innate stress responses in cardiac injury, repair, and remodeling. 
  • Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. 
  • Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. 
  • Dynamic and redundant regulation of LRRK2 and LRRK1 expression. 
  • Dynamic antibody-binding properties in the pathogenesis of HIT. 
  • Dynamic changes in the dendritic geometry of individual neurons visualized over periods of up to three months in the superior cervical ganglion of living mice. 
  • Dynamic contrast-enhanced MR microscopy identifies regions of therapeutic response in a preclinical model of colorectal adenocarcinoma. 
  • Dynamic contrast-enhanced quantitative susceptibility mapping with ultrashort echo time MRI for evaluating renal function. 
  • Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function. 
  • Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism. 
  • Dynamic fractal signature dissimilarity analysis for therapeutic response assessment using dynamic contrast-enhanced MRI. 
  • Dynamic intercellular redistribution of HIT antigen modulates heparin-induced thrombocytopenia. 
  • Dynamic mRNA Transport and Local Translation in Radial Glial Progenitors of the Developing Brain. 
  • Dynamic microRNA gene transcription and processing during T cell development. 
  • Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation. 
  • Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill. 
  • Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. 
  • Dynamin-related Irgm proteins modulate LPS-induced caspase-11 activation and septic shock. 
  • Dysfunctional T cell metabolism in the tumor microenvironment. 
  • Dysregulated activation of fetal liver programme in acute liver failure. 
  • Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. 
  • Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease. 
  • Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice. 
  • Dysregulation of ectonucleotidase-mediated extracellular adenosine during postmenopausal bone loss. 
  • Dysregulation of hedgehog signalling predisposes to synovial chondromatosis. 
  • Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors. 
  • Dysregulation of multiple facets of glycogen metabolism in a murine model of Pompe disease. 
  • Dysregulation of the ESRP2-NF2-YAP/TAZ axis promotes hepatobiliary carcinogenesis in non-alcoholic fatty liver disease. 
  • Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. 
  • Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction. 
  • Dysregulation of the mTOR pathway secondary to mutations or a hostile microenvironment contributes to cancer and poor wound healing. 
  • Déjà Vu But New: Using T Cells to Deplete B Cells to Treat Lupus. 
  • E protein transcription factors are required for the development of CD4(+) lineage T cells. 
  • E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene. 
  • E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma. 
  • E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin. 
  • E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation. 
  • E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex. 
  • E2-induced degradation of uterine insulin receptor substrate-2: requirement for an IGF-I-stimulated, proteasome-dependent pathway. 
  • E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. 
  • E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells. 
  • E2A promotes the survival of precursor and mature B lymphocytes. 
  • E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis. 
  • EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. 
  • EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. 
  • EBV-positive diffuse large B-cell lymphoma of the elderly: 2016 update on diagnosis, risk-stratification, and management. 
  • ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms. 
  • EGF promotes mammalian cell growth by suppressing cellular senescence. 
  • EGFR in enterocytes & endothelium and HIF1α in enterocytes are dispensable for massive small bowel resection induced angiogenesis. 
  • EGFR-upregulated LIFR promotes SUCLG2-dependent castration resistance and neuroendocrine differentiation of prostate cancer. 
  • EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts. 
  • EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss. 
  • EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma. 
  • EGFRvIII-targeted immunotoxin induces antitumor immunity that is inhibited in the absence of CD4+ and CD8+ T cells. 
  • EIF4A3 deficient human iPSCs and mouse models demonstrate neural crest defects that underlie Richieri-Costa-Pereira syndrome. 
  • EJ-Ras inhibits phospholipase C gamma 1 but not actin polymerization induced by platelet-derived growth factor-BB via phosphatidylinositol 3-kinase. 
  • EL-4 metastases in spleen and bone marrow suppress the NK activity generated in these organs. 
  • ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. 
  • ELF3 is a repressor of androgen receptor action in prostate cancer cells. 
  • ELKS1 controls mast cell degranulation by regulating the transcription of Stxbp2 and Syntaxin 4 via Kdm2b stabilization. 
  • ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis. 
  • ENU mutagenesis identifies mice with cardiac fibrosis and hepatic steatosis caused by a mutation in the mitochondrial trifunctional protein beta-subunit. 
  • ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. 
  • ENaC- and CFTR-dependent ion and fluid transport in mammary epithelia. 
  • EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor. 
  • EPCR knockout: inflaming the discussion. 
  • ER Translocation of the MAPK Pathway Drives Therapy Resistance in BRAF-Mutant Melanoma. 
  • ER stress modulates cellular metabolism. 
  • ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum. 
  • ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration. 
  • ERK1/2 mitogen-activated protein kinase selectively mediates IL-13-induced lung inflammation and remodeling in vivo. 
  • ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. 
  • ERα Signaling Increased IL-17A Production in Th17 Cells by Upregulating IL-23R Expression, Mitochondrial Respiration, and Proliferation. 
  • ETS transcription factors regulate an enhancer activity in the third intron of TNF-alpha. 
  • EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development. 
  • Early B-cell activation after West Nile virus infection requires alpha/beta interferon but not antigen receptor signaling. 
  • Early Odorant Exposure Increases the Number of Mitral and Tufted Cells Associated with a Single Glomerulus. 
  • Early adaptive chromatin remodeling events precede pathologic phenotypes and are reinforced in the failing heart. 
  • Early detection and measurement of urothelial tumors in mice. 
  • Early detection of cerebrovascular pathology and protective antiviral immunity by MRI. 
  • Early detection of pemetrexed-induced inhibition of thymidylate synthase in non-small cell lung cancer with FLT-PET imaging. 
  • Early fetal hypoxia leads to growth restriction and myocardial thinning. 
  • Early forming label-retaining muscle stem cells require p27kip1 for maintenance of the primitive state. 
  • Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint. 
  • Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. 
  • Early induction of hepatic deiodinase type 1 inhibits hepatosteatosis during NAFLD progression. 
  • Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. 
  • Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines. 
  • Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo. 
  • Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. 
  • Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia. 
  • Early-Life Intranasal Colonization with Nontypeable Haemophilus influenzae Exacerbates Juvenile Airway Disease in Mice. 
  • Eccentric rehabilitation induces white matter plasticity and sensorimotor recovery in chronic spinal cord injury. 
  • Ecdysone-inducible gene expression in mammalian cells and transgenic mice. 
  • Echocardiographically detected myocardial infarction in the mouse. 
  • Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. 
  • Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes. 
  • Ectopic expression of interferon regulatory factor-1 promotes human breast cancer cell death and results in reduced expression of survivin. 
  • Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice. 
  • Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation. 
  • Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations. 
  • Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema. 
  • Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration. 
  • Effect of CXCL-1/KC production in high risk vascularized corneal allografts on T cell recruitment and graft rejection. 
  • Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. 
  • Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes. 
  • Effect of IGFBP-3 on IGF- and IGF-analogue-induced insulin-like growth factor-I receptor (IGFIR) signalling. 
  • Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture. 
  • Effect of a metalloporphyrin antioxidant (MnTE-2-PyP) on the response of a mouse prostate cancer model to radiation. 
  • Effect of a purified diet on dystrophic cardiac calcinosis in mice. 
  • Effect of adriamycin and Corynebacterium parvum in tumor-bearing mice: modulation of response to sheep red blood cells. 
  • Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer. 
  • Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL-lpr/lpr mice. 
  • Effect of basic fibroblast growth factor on angiogenesis and growth of isografted bone: quantitative in vitro-in vivo analysis in mice. 
  • Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice. 
  • Effect of bismuth salts on systemic and mucosal immune responses to orally administered cholera toxin. 
  • Effect of chemotherapy on uptake of alkali metals by experimental tumors. 
  • Effect of cocaine and cocaine congeners on veratridine-induced depolarization in mouse cerebrocortical synaptoneurosomes. 
  • Effect of compressive force on unbinding specific protein-ligand complexes with force spectroscopy. 
  • Effect of cyclic nucleotides on the induction of ornithine decarboxylase in BHK cells by serum and insulin. 
  • Effect of cyclic stretch on beta1D-integrin expression and activation of FAK and RhoA. 
  • Effect of cytofectins on the immune response of murine macrophages to mammalian DNA. 
  • Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice. 
  • Effect of desiccating environmental stress versus systemic muscarinic AChR blockade on dry eye immunopathogenesis. 
  • Effect of drug release kinetics on nanoparticle therapeutic efficacy and toxicity. 
  • Effect of endotoxin and alum adjuvant vaccine on peanut allergy. 
  • Effect of ethanol on tumor necrosis factor signaling during liver regeneration. 
  • Effect of exposure to light-at-night on life span and spontaneous carcinogenesis in female CBA mice. 
  • Effect of fatty acids on insulin release: role of chain length and degree of unsaturation. 
  • Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice. 
  • Effect of host microenvironment on the microcirculation of human colon adenocarcinoma. 
  • Effect of immunosuppressants on T-cell subsets observed in vivo using carboxy-fluorescein diacetate succinimidyl ester labeling. 
  • Effect of interferon on murine leukemia virus infection. II. Synthesis of viral components in exogenous infection. 
  • Effect of interferon-gamma and human alpha 2-macroglobulin on peritoneal macrophage morphology and Ia antigen expression. 
  • Effect of interleukin-1β on the expression of actin isoforms in cultured mouse astroglia. 
  • Effect of intraocular gamma-interferon on immunoregulatory properties of iris and ciliary body cells. 
  • Effect of irradiation on cytokine production, MHC antigen expression, and vaccine potential of interleukin-2 and interferon-gamma gene-modified melanoma cells. 
  • Effect of microRNA modulation on bioartificial muscle function. 
  • Effect of nandrolone decanoate administration on recovery from bupivacaine-induced muscle injury. 
  • Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging. 
  • Effect of obesity on pulmonary inflammation induced by acute ozone exposure: role of interleukin-6. 
  • Effect of oxidative stress on homer scaffolding proteins. 
  • Effect of p38 MAP kinases on contractility and ischemic injury in intact heart. 
  • Effect of pain management on immunization efficacy in mice. 
  • Effect of pazopanib on tumor microenvironment and liposome delivery. 
  • Effect of poly(ethylene glycol) diacrylate concentration on network properties and in vivo response of poly(β-amino ester) networks. 
  • Effect of preexposure to ultrafine carbon black on respiratory syncytial virus infection in mice. 
  • Effect of propranolol as antiadhesive therapy in sickle cell disease. 
  • Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer. 
  • Effect of receptor number on desensitization of the mouse thromboxane receptor. 
  • Effect of sera from myasthenia gravis patients on acetylcholine receptors in myotube cultures. 
  • Effect of sex on the induction of anti-DNA antibodies in normal mice immunized with bacterial DNA. 
  • Effect of sulfur substitution for the noncarbonyl oxygen in hemicholinium-3 and acetyl-seco-hemicholinium-3. Synthesis, biological activity, and structure-toxicity relationships. 
  • Effect of surface topography on in vitro osteoblast function and mechanical performance of 3D printed titanium. 
  • Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice. 
  • Effect of temperature on blood flow and hypoxic fraction in a murine fibrosarcoma. 
  • Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans. 
  • Effect of the monoamine oxidase inhibitors clorgyline and pargyline on the hyperphagia of obese mice. 
  • Effect of the nitric oxide donor V-PYRRO/NO on portal pressure and sinusoidal dynamics in normal and cirrhotic mice. 
  • Effect of topical azithromycin on corneal innate immune responses. 
  • Effect of transient hydronephrosis on subsequent compensatory renal growth. 
  • Effect of vasoactive intestinal peptide (VIP) on cytokine production and expression of VIP receptors in thymocyte subsets. 
  • Effect of virus infection on the inflammatory response. Depression of macrophage accumulation in influenza-infected mice. 
  • Effect os xid on anti-DNA B-cell precursors. 
  • Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. 
  • Effective antibody therapy in herpes simplex virus ocular infection. Characterization of recipient immune response. 
  • Effective breast cancer combination therapy targeting BACH1 and mitochondrial metabolism. 
  • Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1. 
  • Effective treatment of experimental DU-145 prostate cancers with targeted cytotoxic somatostatin analog AN-238. 
  • Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors. 
  • Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation. 
  • Effectiveness of combined interleukin 2 and B7.1 vaccination strategy is dependent on the sequence and order: a liposome-mediated gene therapy treatment for bladder cancer. 
  • Effector T Cell Egress via Afferent Lymph Modulates Local Tissue Inflammation. 
  • Effector mechanisms of cytolytically activated macrophages. II. Secretion of a cytolytic factor by activated macrophages and its relationship to secreted neutral proteases. 
  • Effects and potential mechanisms of exercise training on cancer progression: a translational perspective. 
  • Effects of 10-hydroxycamptothecin, delivered from locally injectable poly(lactide-co-glycolide) microspheres, in a murine human oral squamous cell carcinoma regression model. 
  • Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice. 
  • Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products. 
  • Effects of Cell-Based Therapy for Treating Tympanic Membrane Perforations in Mice. 
  • Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators. 
  • Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies. 
  • Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis. 
  • Effects of Helicobacter infection on research: the case for eradication of Helicobacter from rodent research colonies. 
  • Effects of IL-1 on hematopoietic progenitors after myelosuppressive chemoradiotherapy. 
  • Effects of Long-Term Vagus Nerve Electrical Stimulation Therapy on Acute Cerebral Infarction and Neurological Function Recovery in Post MCAO Mice. 
  • Effects of N-acetylcysteine in ozone-induced chronic obstructive pulmonary disease model. 
  • Effects of Space Flight on Mouse Liver versus Kidney: Gene Pathway Analyses. 
  • Effects of Y27632 on keratinocyte procurement and wound healing. 
  • Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice. 
  • Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition. 
  • Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model. 
  • Effects of a novel arginine methyltransferase inhibitor on T-helper cell cytokine production. 
  • Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL/6J and BALB/cJ mice. 
  • Effects of allergic airway disease on mouse adenovirus type 1 respiratory infection. 
  • Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells. 
  • Effects of bacterial DNA on cytokine production by (NZB/NZW)F1 mice. 
  • Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages. 
  • Effects of calcium on ACTH stimulation of the adrenal: separation of hormone binding from adenyl cyclase activation. 
  • Effects of candesartan on angiotensin II-induced renal vasoconstriction in rats and mice. 
  • Effects of castration and chronic steroid treatments on hypothalamic gonadotropin-releasing hormone content and pituitary gonadotropins in male wild-type and estrogen receptor-alpha knockout mice. 
  • Effects of chemically induced ovarian failure on voluntary wheel-running exercise and cardiac adaptation in mice. 
  • Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage. 
  • Effects of chronic exposure to simulated microgravity on skeletal muscle cell proliferation and differentiation. 
  • Effects of classical and atypical antipsychotic drugs on isolation-induced aggression in male mice. 
  • Effects of cyclosporine on human B-cell lymphoma development in vivo. 
  • Effects of glutathione or polyamine depletion on in vivo thermosensitization. 
  • Effects of growth hormone and IGF-I on cardiac hypertrophy and gene expression in mice. 
  • Effects of high-dose microbeam irradiation on tumor microvascular function and angiogenesis. 
  • Effects of hyperthermia and irradiation on the growth of mouse melanoma tumors following immunotherapy. 
  • Effects of iron deficiency anemia and its treatment on fibroblast growth factor 23 and phosphate homeostasis in women. 
  • Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors. 
  • Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice. 
  • Effects of murine cytomegalovirus infection on the immune response to a tumor allograft. 
  • Effects of myocardial infarction on the distribution and transport of nutrients and oxygen in porcine myocardium. 
  • Effects of neoplasms on inflammation: depression of macrophage accumulation after tumor implantation. 
  • Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond. 
  • Effects of nitric oxide releasing poly(vinyl alcohol) hydrogel dressings on dermal wound healing in diabetic mice. 
  • Effects of nitrogen mustard and splenectomy on mouse bone marrow colony formation in vitro. 
  • Effects of nociceptin (13-17) in pain modulation at supraspinal level in mice. 
  • Effects of oxidized LDL on mononuclear phagocytes: inhibition of induction of four inflammatory cytokine gene RNAs, release of NO, and cytolysis of tumor cells. 
  • Effects of oxygen on the metabolism of murine tumors using in vivo phosphorus-31 NMR. 
  • Effects of pentobarbital anesthesia on the energy metabolism of murine tumors studied by in vivo 31P nuclear magnetic resonance spectroscopy. 
  • Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice. 
  • Effects of pimozide and penfluridol on the binding and endocytosis of alpha 2-macroglobulin-CH3NH2 by mouse peritoneal macrophages. 
  • Effects of progesterone and estradiol sex hormones on the release of microparticles by RAW 264.7 macrophages stimulated by Poly(I:C). 
  • Effects of rate, volume, and dose of intratumoral infusion on virus dissemination in local gene delivery. 
  • Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats. 
  • Effects of sex and genotype in human APOE-targeted replacement mice on alcohol self-administration measured with the automated IntelliCage system before and after repeated mild traumatic brain injury. 
  • Effects of simvastatin on retinal structure and function of a high-fat atherogenic mouse model of thickened Bruch's membrane. 
  • Effects of sodium fluoroacetate on the metabolism of N-acetylaspartate and aspartate in mouse brain. 
  • Effects of spaceflight on murine skeletal muscle gene expression. 
  • Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis. 
  • Effects of the lpr mutation on elimination and inactivation of self-reactive B cells. 
  • Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts. 
  • Effects of the sazetidine-a family of compounds on the body temperature in wildtype, nicotinic receptor β2-/- and α7-/- mice. 
  • Effects of therapy on the 1H NMR spectrum of a human glioma line. 
  • Effects of topical and subconjunctival bevacizumab in high-risk corneal transplant survival. 
  • Effects of tumor growth on host defenses. 
  • Effects of tumor microenvironment heterogeneity on nanoparticle disposition and efficacy in breast cancer tumor models. 
  • Effects of tumor necrosis factor on viral replication and pulmonary inflammation during acute mouse adenovirus type 1 respiratory infection. 
  • Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. 
  • Efferent synapses return to inner hair cells in the aging cochlea. 
  • Efficacious Androgen Hormone Administration in Combination with Adeno-Associated Virus Vector-Mediated Gene Therapy in Female Mice with Pompe Disease. 
  • Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer. 
  • Efficacy and pharmacokinetics of a modified acid-labile docetaxel-PRINT(®) nanoparticle formulation against non-small-cell lung cancer brain metastases. 
  • Efficacy and toxicity of 9-beta-D-arabinofuranosylguanine (araG) as an agent to purge malignant T cells from murine bone marrow: application to an in vivo T-leukemia model. 
  • Efficacy of Carboplatin Alone and in Combination with ABT888 in Intracranial Murine Models of BRCA-Mutated and BRCA-Wild-Type Triple-Negative Breast Cancer. 
  • Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer. 
  • Efficacy of an abbreviated induction regimen of amphotericin B deoxycholate for cryptococcal meningoencephalitis: 3 days of therapy is equivalent to 14 days. 
  • Efficacy of an adeno-associated virus 8-pseudotyped vector in glycogen storage disease type II. 
  • Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans. 
  • Efficacy of auranofin as an inhibitor of desmoid progression. 
  • Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis. 
  • Efficacy of gene therapy for a prototypical lysosomal storage disease (GSD-II) is critically dependent on vector dose, transgene promoter, and the tissues targeted for vector transduction. 
  • Efficacy of helper-dependent adenovirus vector-mediated gene therapy in murine glycogen storage disease type Ia. 
  • Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release. 
  • Efficacy of multiple administrations of a recombinant adenovirus expressing wild-type p53 in an immune-competent mouse tumor model. 
  • Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma. 
  • Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors. 
  • Efficient CD4Cre-Mediated Conditional KRas Expression in Alveolar Macrophages and Alveolar Epithelial Cells Causes Fatal Hyperproliferative Pneumonitis. 
  • Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. 
  • Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent. 
  • Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin. 
  • Efficient intratracheal delivery of airway epithelial cells in mice and pigs. 
  • Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin. 
  • Efficient purification and metabolite analysis of radiotracers using high-performance liquid chromatography and on-line solid-phase extraction. 
  • Efficient quantification of afferent cochlear ultrastructure using design-based stereology. 
  • Efficient transdifferentiation of human dermal fibroblasts into skeletal muscle. 
  • Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. 
  • Ehrlichiosis in children. 
  • Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. 
  • Elastic hydrogel as a sensor for detection of mechanical stress generated by single cells grown in three-dimensional environment. 
  • Elastomeric polyamide biomaterials with stereochemically tuneable mechanical properties and shape memory. 
  • Electric field-mediated transport of plasmid DNA in tumor interstitium in vivo. 
  • Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery. 
  • Electrical coupling mediates tunable low-frequency oscillations and resonance in the cerebellar Golgi cell network. 
  • Electromobility of plasmid DNA in tumor tissues during electric field-mediated gene delivery. 
  • Electron transport complex I is required for CD8+ T cell function. 
  • Electrophoretic analysis of four high molecular weight sialoglycoproteins produced by metastatic human colon carcinoma cells. 
  • Electrophysiological and biochemical characteristics of Gymnodinium breve toxins. 
  • Electrotonic influences on action potential duration dispersion in small hearts: a simulation study. 
  • Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. 
  • Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan. 
  • Elevated Urinary Rab10 Phosphorylation in Idiopathic Parkinson Disease. 
  • Elevated beta-cell calmodulin produces a unique insulin secretory defect in transgenic mice. 
  • Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. 
  • Elevated chemokine responses are maintained in lungs after clearance of viral infection. 
  • Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. 
  • Elevated expression of a subset of interferon inducible genes in primary bone marrow cells expressing p185 Bcr-Abl versus p210 Bcr-Abl by DNA microarray analysis. 
  • Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. 
  • Elevated resistin levels induce central leptin resistance and increased atherosclerotic progression in mice. 
  • Eliciting and Analyzing Male Mouse Ultrasonic Vocalization (USV) Songs. 
  • Eliminating antibody polyreactivity through addition of N-linked glycosylation. 
  • Elimination of mycoplasma from human B-lymphoblastoid cell lines. 
  • Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration. 
  • Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence. 
  • Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approach. 
  • Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons. 
  • Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. 
  • Embryonic and neonatal cardiac gene transfer in vivo. 
  • Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. 
  • Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit. 
  • Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1), which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase. 
  • Embryonic expression patterns of the neural cell adhesion molecule gene are regulated by homeodomain binding sites. 
  • Embryonic germ cell lines and their derivation from mouse primordial germ cells. 
  • Embryonic germ cells are capable of adipogenic differentiation in vitro and in vivo. 
  • Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages. 
  • Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States. 
  • Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice. 
  • Emergence of anxiety-like behaviours in depressive-like Cpe(fat/fat) mice. 
  • Emerging Skin T-Cell Functions in Response to Environmental Insults. 
  • Emerging infectious diseases in an island ecosystem: the New Zealand perspective. 
  • Emergomyces africanus in Soil, South Africa. 
  • Employing Macrophage-Derived Microvesicle for Kidney-Targeted Delivery of Dexamethasone: An Efficient Therapeutic Strategy against Renal Inflammation and Fibrosis. 
  • En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase. 
  • Enabling hyperpolarized (129) Xe MR spectroscopy and imaging of pulmonary gas transfer to the red blood cells in transgenic mice expressing human hemoglobin. 
  • Enabling sublingual peptide immunization with molecular self-assemblies. 
  • Encapsulation of Adenovirus BMP2-Transduced Cells with PEGDA Hydrogels Allows Bone Formation in the Presence of Immune Response. 
  • EndoU is a novel regulator of AICD during peripheral B cell selection. 
  • Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cells. 
  • Endocytosis of Red Blood Cell Microparticles by Pulmonary Endothelial Cells is Mediated By Rab5. 
  • Endocytosis of red blood cells or haemoglobin by activated macrophages inhibits their tumoricidal effect. 
  • Endogenous CCN family member WISP1 inhibits trauma-induced heterotopic ossification. 
  • Endogenous IL-12 is required for induction and expression of experimental autoimmune uveitis. 
  • Endogenous Retrovirus Activation as a Key Mechanism of Anti-Tumor Immune Response in Radiotherapy. 
  • Endogenous S-nitrosothiols protect against myocardial injury. 
  • Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production. 
  • Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. 
  • Endogenous expression of transforming growth factor beta1 inhibits growth and tumorigenicity and enhances Fas-mediated apoptosis in a murine high-grade glioma model. 
  • Endogenous glucocorticoids prevent gastric metaplasia by suppressing spontaneous inflammation. 
  • Endogenous oncogenic Nras mutation initiates hematopoietic malignancies in a dose- and cell type-dependent manner. 
  • Endogenous oncogenic Nras mutation promotes aberrant GM-CSF signaling in granulocytic/monocytic precursors in a murine model of chronic myelomonocytic leukemia. 
  • Endogenous polymers of ADP-ribose are associated with the nuclear matrix. 
  • Endogenous production of extracellular adenosine by trabecular meshwork cells: potential role in outflow regulation. 
  • Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. 
  • Endoglin deficiency impairs stroke recovery. 
  • Endoglin interacts with VEGFR2 to promote angiogenesis. 
  • Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC. 
  • Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis. 
  • Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. 
  • Endoplasmic reticulum sorting and kinesin-1 command the targeting of axonal GABAB receptors. 
  • Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers. 
  • Endostatin inhibits the vascular endothelial growth factor-induced mobilization of endothelial progenitor cells. 
  • Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation. 
  • Endothelial CD74 mediates macrophage migration inhibitory factor protection in hyperoxic lung injury. 
  • Endothelial Cell-Derived Extracellular Vesicles Mitigate Radiation-Induced Hematopoietic Injury. 
  • Endothelial MKK3 is a critical mediator of lethal murine endotoxemia and acute lung injury. 
  • Endothelial PINK1 mediates the protective effects of NLRP3 deficiency during lethal oxidant injury. 
  • Endothelial STAT3 is essential for the protective effects of HO-1 in oxidant-induced lung injury. 
  • Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development. 
  • Endothelial Stanniocalcin 1 Maintains Mitochondrial Bioenergetics and Prevents Oxidant-Induced Lung Injury via Toll-Like Receptor 4. 
  • Endothelial Stromal PD-L1 (Programmed Death Ligand 1) Modulates CD8+ T-Cell Infiltration After Heart Transplantation. 
  • Endothelial TRPV4 channels prevent tumor growth and metastasis via modulation of tumor angiogenesis and vascular integrity. 
  • Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. 
  • Endothelial antigen presentation: stimulation of previously activated but not naïve TCR-transgenic mouse T cells. 
  • Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. 
  • Endothelial cell Pannexin1 modulates severity of ischemic stroke by regulating cerebral inflammation and myogenic tone. 
  • Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. 
  • Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesis. 
  • Endothelial cell-secreted MIF reduces pericyte contractility and enhances neutrophil extravasation. 
  • Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin. 
  • Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. 
  • Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. 
  • Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. 
  • Endothelial toll-like receptor 4 maintains lung integrity via epigenetic suppression of p16INK4a. 
  • Endothelial uncoupling protein 2 regulates mitophagy and pulmonary hypertension during intermittent hypoxia. 
  • Endothelial, cardiac muscle and skeletal muscle exhibit different viscous and elastic properties as determined by atomic force microscopy. 
  • Endotoxin (LPS) stimulates in vitro migration of macrophages from LPS-resistant mice but not from LPS-sensitive mice. 
  • Endotoxin and NO induce MIP-1gamma gene transcription in ANA-1 murine macrophages. 
  • Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle. 
  • Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression. 
  • Endotoxin-mediated S-nitrosylation of p50 alters NF-kappa B-dependent gene transcription in ANA-1 murine macrophages. 
  • Endotoxin-mediated nitric oxide synthesis inhibits IL-1beta gene transcription in ANA-1 murine macrophages. 
  • Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction. 
  • Endotoxin-stimulated nitric oxide production inhibits expression of cytochrome c oxidase in ANA-1 murine macrophages. 
  • Endovascular middle cerebral artery embolic stroke model: a novel approach. 
  • Endurance exercise attenuates juvenile irradiation-induced skeletal muscle functional decline and mitochondrial stress. 
  • Endurance exercise training increases adipose tissue glucocorticoid exposure: adaptations that facilitate lipolysis. 
  • Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach. 
  • Energy metabolism in uncoupling protein 3 gene knockout mice. 
  • Enforced expression of FGF-7 promotes epithelial hyperplasia whereas a dominant negative FGFR2iiib promotes the emergence of neuroendocrine phenotype in prostate glands of transgenic mice. 
  • Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus. 
  • Engagement of NKG2D on bystander memory CD8 T cells promotes increased immunopathology following Leishmania major infection. 
  • Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. 
  • Engineered bacterial voltage-gated sodium channel platform for cardiac gene therapy. 
  • Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active. 
  • Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. 
  • Engineered skeletal muscle tissue networks with controllable architecture. 
  • Engineering Controlled Peritumoral Inflammation to Constrain Brain Tumor Growth. 
  • Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes. 
  • Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. 
  • Engineering and Selection of Shuffled AAV Genomes: A New Strategy for Producing Targeted Biological Nanoparticles. 
  • Engineering liver-detargeted AAV9 vectors for cardiac and musculoskeletal gene transfer. 
  • Engineering soluble major histocompatibility molecules: why and how. 
  • Engraftment of a galactose receptor footprint onto adeno-associated viral capsids improves transduction efficiency. 
  • Engraftment of human synovium into severe combined immune deficient mice. Migration of human peripheral blood T cells to engrafted human synovium and to mouse lymph nodes. 
  • Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism. 
  • Enhanced Galphaq signaling: a common pathway mediates cardiac hypertrophy and apoptotic heart failure. 
  • Enhanced In Vivo Delivery of Stem Cells using Microporous Annealed Particle Scaffolds. 
  • Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. 
  • Enhanced T2 contrast for MR histology of the mouse brain. 
  • Enhanced Th17-cell responses render CCR2-deficient mice more susceptible for autoimmune arthritis. 
  • Enhanced activation of human dendritic cells by inducible CD40 and Toll-like receptor-4 ligation. 
  • Enhanced allergen-induced airway inflammation in paucity of lymph node T cell (plt) mutant mice. 
  • Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes. 
  • Enhanced avidity maturation of antibody to human immunodeficiency virus envelope: DNA vaccination with gp120-C3d fusion proteins. 
  • Enhanced binding and inertness to dehalogenation of alpha-melanotropic peptides labeled using N-succinimidyl 3-iodobenzoate. 
  • Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein. 
  • Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2. 
  • Enhanced cardiac function in transgenic mice expressing a Ca(2+)-stimulated adenylyl cyclase. 
  • Enhanced central response to dehydration in mice lacking angiotensin AT(1a) receptors. 
  • Enhanced chondrogenic differentiation of embryonic stem cells by coculture with hepatic cells. 
  • Enhanced chondrogenic differentiation of murine embryonic stem cells in hydrogels with glucosamine. 
  • Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine. 
  • Enhanced delivery of a monoclonal antibody F(ab')2 fragment to subcutaneous human glioma xenografts using local hyperthermia. 
  • Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice. 
  • Enhanced efficacy from gene therapy in Pompe disease using coreceptor blockade. 
  • Enhanced efficacy of an AAV vector encoding chimeric, highly secreted acid alpha-glucosidase in glycogen storage disease type II. 
  • Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. 
  • Enhanced efficacy of enzyme replacement therapy in Pompe disease through mannose-6-phosphate receptor expression in skeletal muscle. 
  • Enhanced gene expression of systemically administered plasmid DNA in the liver with therapeutic ultrasound and microbubbles. 
  • Enhanced green fluorescent protein as a marker for localizing murine cytomegalovirus in acute and latent infection. 
  • Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I. 
  • Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone. 
  • Enhanced in vivo cytotoxicity of recombinant human tumor necrosis factor with etoposide in human renal cell carcinoma. Evaluation in a pre-clinical model. 
  • Enhanced inflow and outflow rates despite lower IOP in bestrophin-2-deficient mice. 
  • Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation. 
  • Enhanced malignant tumorigenesis in Cdk4 transgenic mice. 
  • Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice. 
  • Enhanced morphine analgesia in mice lacking beta-arrestin 2. 
  • Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. 
  • Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein. 
  • Enhanced neonatal Fc receptor function improves protection against primate SHIV infection. 
  • Enhanced oncolytic activity of vesicular stomatitis virus encoding SV5-F protein against prostate cancer. 
  • Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by coculture with macrophage feeder cells. 
  • Enhanced pancreatic cancer gene therapy by combination of adenoviral vector expressing c-erb-B2 (Her-2/neu)-targeted immunotoxin with a replication-competent adenovirus or etoposide. 
  • Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. 
  • Enhanced priming of adaptive immunity by Mycobacterium smegmatis mutants with high-level protein secretion. 
  • Enhanced production of superoxide anion by microglia from trisomy 16 mice. 
  • Enhanced refocusing of fat signals using optimized multipulse echo sequences. 
  • Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites. 
  • Enhanced response to enzyme replacement therapy in Pompe disease after the induction of immune tolerance. 
  • Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. 
  • Enhanced stability of tristetraprolin mRNA protects mice against immune-mediated inflammatory pathologies. 
  • Enhanced therapeutic neovascularization by CD31-expressing cells and embryonic stem cell-derived endothelial cells engineered with chitosan hydrogel containing VEGF-releasing microtubes 
  • Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus. 
  • Enhanced transduction and improved photoreceptor survival of retinal degeneration by the combinatorial use of rAAV2 with a lower dose of adenovirus. 
  • Enhanced tumor localization and in vivo stability of a monoclonal antibody radioiodinated using N-succinimidyl 3-(tri-n-butylstannyl)benzoate. 
  • Enhanced tumour uptake and in vitro radiotoxicity of no-carrier-added [131I]meta-iodobenzylguanidine: implications for the targeted radiotherapy of neuroblastoma. 
  • Enhanced tumour uptake of radiolabelled antibodies by hyperthermia. Part II: Application of the thermal equivalency equation. 
  • Enhanced tumour uptake of radiolabelled antibodies by hyperthermia: Part I: Timing of injection relative to hyperthermia. 
  • Enhanced type 1 immunity after secondary viral challenge in mice primed as neonates. 
  • Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm's Canal Endothelia. 
  • Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells. 
  • Enhancement of antibodies to the human immunodeficiency virus type 1 envelope by using the molecular adjuvant C3d. 
  • Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression. 
  • Enhancement of dopaminergic properties and protection mediated by neuronal activation of Ras in mouse ventral mesencephalic neurones. 
  • Enhancement of electric field-mediated gene delivery through pretreatment of tumors with a hyperosmotic mannitol solution. 
  • Enhancement of endocrine pancreatic secretions by essential fatty acids. 
  • Enhancement of experimental anaerobic infections by blood, hemoglobin, and hemostatic agents. 
  • Enhancement of irinotecan (CPT-11) activity against central nervous system tumor xenografts by alkylating agents. 
  • Enhancement of macrophage-mediated tumor cell killing by bacterial outer membrane proteins (porins). 
  • Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta. 
  • Enhancement of melphalan-induced gastrointestinal toxicity in mice treated with regional hyperthermia and BSO-mediated glutathione depletion. 
  • Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. 
  • Enhancement of rAAV2-mediated transgene expression in retina cells in vitro and in vivo by coadministration of low-dose chemotherapeutic drugs. 
  • Enhancement of radiotherapy by hyperthermia-regulated gene therapy. 
  • Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes. 
  • Enhancer analysis of the mouse HNF-3 beta gene: regulatory elements for node/notochord and floor plate are independent and consist of multiple sub-elements. 
  • Enhancer control of local accessibility to V(D)J recombinase. 
  • Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes. 
  • Enhancing KDM5A and TLR activity improves the response to immune checkpoint blockade. 
  • Enhancing Radiation Therapy Through Cherenkov Light-Activated Phototherapy. 
  • Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds. 
  • Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand. 
  • Enrichment of endogenous fractalkine and anti-inflammatory cells via aptamer-functionalized hydrogels. 
  • Enrichment of putative prostate cancer stem cells after androgen deprivation: upregulation of pluripotency transactivators concurs with resistance to androgen deprivation in LNCaP cell lines. 
  • Enterocyte-innate lymphoid cell crosstalk drives early IFN-γ-mediated control of Cryptosporidium. 
  • Enterotoxigenic Escherichia coli vesicles target toxin delivery into mammalian cells. 
  • Enterovirus Replication and Dissemination Are Differentially Controlled by Type I and III Interferons in the Gastrointestinal Tract. 
  • Environmental Factors Modify the Severity of Acute DSS Colitis in Caspase-11-Deficient Mice. 
  • Environmental oxygen regulates astrocyte proliferation to guide angiogenesis during retinal development. 
  • Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. 
  • Environmentally relevant xenoestrogen tissue concentrations correlated to biological responses in mice. 
  • Enzymes that counteract nitrosative stress promote fungal virulence. 
  • Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid. 
  • Eosinophils alter colonic epithelial barrier function: role for major basic protein. 
  • EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase. 
  • Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration. 
  • Epidermal growth factor alters metabolism of inositol lipids and activity of protein kinase C in mouse embryo palate mesenchyme cells. 
  • Epidermal growth factor augments adaptation following small bowel resection: optimal dosage, route, and timing of administration. 
  • Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene. 
  • Epidermal growth factor receptor VIII peptide vaccination is efficacious against established intracerebral tumors. 
  • Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. 
  • Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. 
  • Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice. 
  • Epidermal growth factor regulates hematopoietic regeneration after radiation injury. 
  • Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation. 
  • Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance. 
  • Epigenetic Heterogeneity in Human Colorectal Tumors Reveals Preferential Conservation And Evidence of Immune Surveillance. 
  • Epigenetic Regulation of Fanconi Anemia Genes Implicates PRMT5 Blockage as a Strategy for Tumor Chemosensitization. 
  • Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia. 
  • Epigenetic Switch-Induced Viral Mimicry Evasion in Chemotherapy-Resistant Breast Cancer. 
  • Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. 
  • Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. 
  • Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. 
  • Epigenetic silencing of tumor suppressor Par-4 promotes chemoresistance in recurrent breast cancer. 
  • Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition. 
  • Epigenetics and the regulation of stress vulnerability and resilience. 
  • Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency. 
  • Epigenomic diversity of cortical projection neurons in the mouse brain. 
  • Epilepsy genetics: an abundance of riches for biologists. 
  • Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo. 
  • Epiregulin and EGFR interactions are involved in pain processing. 
  • Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice. 
  • Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis. 
  • Epithelial Smad4 Deletion Up-Regulates Inflammation and Promotes Inflammation-Associated Cancer. 
  • Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. 
  • Epithelial progenitor cells of the embryonic lung and the role of microRNAs in their proliferation. 
  • Epithelial splicing regulatory protein 2-mediated alternative splicing reprograms hepatocytes in severe alcoholic hepatitis. 
  • Epithelial stem/progenitor cells in lung postnatal growth, maintenance, and repair. 
  • Epithelial-mesenchymal transition in prostate cancer: providing new targets for therapy. 
  • Epithelial-mesenchymal transitions and hepatocarcinogenesis. 
  • Epitope insertion into variable loops of HIV-1 gp120 as a potential means to improve immunogenicity of viral envelope protein. 
  • Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine. 
  • Epstein Barr virus nuclear antigen 1 (EBNA-1) peptides recognized by adult multiple sclerosis patient sera induce neurologic symptoms in a murine model. 
  • Epstein-Barr Viruses (EBVs) Deficient in EBV-Encoded RNAs Have Higher Levels of Latent Membrane Protein 2 RNA Expression in Lymphoblastoid Cell Lines and Efficiently Establish Persistent Infections in Humanized Mice. 
  • Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection. 
  • Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation. 
  • Eradication of melanoma pulmonary metastases by immunotherapy with tumor cells engineered to secrete interleukin-2 or gamma interferon. 
  • Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus. 
  • Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth. 
  • Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4. 
  • Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium. 
  • Erythrocyte-Derived Microparticles Activate Pulmonary Endothelial Cells in a Murine Model of Transfusion. 
  • Erythroid AP-1/NF-E2 elements vary in their response to NF-E2. 
  • Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. 
  • Erythroid-specific expression of human CD59 and transfer to vascular endothelial cells. 
  • Erythromyeloid progenitors give rise to a population of osteoclasts that contribute to bone homeostasis and repair. 
  • Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling. 
  • Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. 
  • Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression. 
  • Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain. 
  • Erythropoietin mediates terminal granulocytic differentiation of committed myeloid cells with ectopic erythropoietin receptor expression. 
  • Erythropoietin receptor contains both growth-promoting activity and differentiation-promoting activity. 
  • Erythropoietin receptor contributes to melanoma cell survival in vivo. 
  • Erythropoietin receptor signals both proliferation and erythroid-specific differentiation. 
  • Escape from tolerance in the human X-linked autoimmunity-allergic disregulation syndrome and the Scurfy mouse. 
  • Escherichia coli global gene expression in urine from women with urinary tract infection. 
  • Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages. 
  • Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation. 
  • Essential cell-extrinsic requirement for PDIA6 in lymphoid and myeloid development. 
  • Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells. 
  • Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. 
  • Essential role of AT1A receptor in the development of 2K1C hypertension. 
  • Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. 
  • Essential role of LAT in T cell development. 
  • Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia. 
  • Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. 
  • Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. 
  • Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. 
  • Establishing an accurate gas phase reference frequency to quantify 129 Xe chemical shifts in vivo. 
  • Establishing the epigenetic status of the Prader-Willi/Angelman imprinting center in the gametes and embryo. 
  • Establishment and characterization of a new human prostatic carcinoma cell line (DuPro-1). 
  • Establishment and characterization of conditionally immortalized cells from the mouse urogenital ridge. 
  • Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med. 
  • Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion. 
  • Establishment of an index with increased sensitivity for assessing murine arthritis. 
  • Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. 
  • Esterified Trehalose Analogues Protect Mammalian Cells from Heat Shock. 
  • Estimation of primate speciation dates using local molecular clocks. 
  • Estradiol enhances long term potentiation in hippocampal slices from aged apoE4-TR mice. 
  • Estradiol replacement enhances cocaine-stimulated locomotion in female C57BL/6 mice through estrogen receptor alpha. 
  • Estradiol replacement therapy regulates innate immune response in ovariectomized arthritic mice. 
  • Estrogen mediates neuroprotection and anti-inflammatory effects during EAE through ERα signaling on astrocytes but not through ERβ signaling on astrocytes or neurons. 
  • Estrogen metabolism within the lung and its modulation by tobacco smoke. 
  • Estrogen protects against intracranial aneurysm rupture in ovariectomized mice. 
  • Estrogen receptor beta protects against in vivo injury in RPE cells. 
  • Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes. 
  • Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy. 
  • Estrogen receptor-β ligand treatment after disease onset is neuroprotective in the multiple sclerosis model. 
  • Estrogen regulation of aquaporins in the mouse uterus: potential roles in uterine water movement. 
  • Estrogen stimulation and tamoxifen inhibition of leiomyoma cell growth in vitro and in vivo. 
  • Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. 
  • Estrogen/antiestrogen responsiveness in an in vivo/in vitro model for myometrial tumorigenesis. 
  • Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. 
  • Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. 
  • Ethanol contributes to neurogenic pancreatitis by activation of TRPV1. 
  • Ethanol induces redox-sensitive cell-cycle inhibitors and inhibits liver regeneration after partial hepatectomy. 
  • Ethanol metabolism modifies hepatic protein acylation in mice. 
  • Ethanol-induced face-brain dysmorphology patterns are correlative and exposure-stage dependent. 
  • Ether lipid metabolism by AADACL1 regulates platelet function and thrombosis. 
  • Ethosuximide reduces ethanol withdrawal-mediated disruptions in sleep-related EEG patterns. 
  • Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation. 
  • Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance. 
  • Ethylenecarbodiimide-treated splenocytes carrying male CD4 epitopes confer histocompatibility Y chromosome antigen transplant protection by inhibiting CD154 upregulation. 
  • Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure. 
  • Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. 
  • Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III. 
  • EuroPhenome: a repository for high-throughput mouse phenotyping data. 
  • Evaluating Skilled Prehension in Mice Using an Auto-Trainer. 
  • Evaluating cytokine production by flow cytometry using brefeldin A in mice. 
  • Evaluation of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-methyl-2-(S)-pyrrolidinylmethoxy)pyridine and its analogues as PET radioligands for imaging nicotinic acetylcholine receptors. 
  • Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis. 
  • Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia. 
  • Evaluation of M2-like macrophage enrichment after diffuse traumatic brain injury through transient interleukin-4 expression from engineered mesenchymal stromal cells. 
  • Evaluation of Maternal, Embryo, and Placental Effects in CD-1 Mice following Gestational Exposure to Perfluorooctanoic Acid (PFOA) or Hexafluoropropylene Oxide Dimer Acid (HFPO-DA or GenX). 
  • Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood. 
  • Evaluation of a recombinant yeast cell estrogen screening assay. 
  • Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK. 
  • Evaluation of an improved fiberoptics luminescence skin monitor with background correction. 
  • Evaluation of an internalizing monoclonal antibody labeled using N-succinimidyl 3-[131I]iodo-4-phosphonomethylbenzoate ([131I]SIPMB), a negatively charged substituent bearing acylation agent. 
  • Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas. 
  • Evaluation of antihypertensive drugs in combination with enzyme replacement therapy in mice with Pompe disease. 
  • Evaluation of complex inheritance involving the most common Bardet-Biedl syndrome locus (BBS1). 
  • Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain. 
  • Evaluation of humoral, mucosal, and cellular immune responses following co-immunization of HIV-1 Gag and Env proteins expressed by Newcastle disease virus. 
  • Evaluation of meta-[211At]astatobenzylguanidine in an athymic mouse human neuroblastoma xenograft model. 
  • Evaluation of new anticancer agents against human pancreatic carcinomas in nude mice. 
  • Evaluation of p-amidinophenyl esters as potential antithrombotic agents. 
  • Evaluation of penicillin and hyperbaric oxygen in the treatment of streptococcal myositis. 
  • Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice. 
  • Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy. 
  • Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study. 
  • Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader. 
  • Evaluation of the rapid plasma elimination of recombinant alpha 1-proteinase inhibitor: synthesis of polyethylene glycol conjugates with improved therapeutic potential. 
  • Evaluation of tumor microenvironment in an animal model using a nanoparticle contrast agent in computed tomography imaging. 
  • Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo. 
  • Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II. 
  • Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model. 
  • Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis. 
  • Evidence for a second alpha 2-macroglobulin receptor. 
  • Evidence for an alternative glycolytic pathway in rapidly proliferating cells. 
  • Evidence for an immune barrier after in utero hematopoietic-cell transplantation. 
  • Evidence for disruption of sphingolipid metabolism as a contributing factor in the toxicity and carcinogenicity of fumonisins. 
  • Evidence for epithelial-mesenchymal transitions in adult liver cells. 
  • Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system. 
  • Evidence for positive and negative regulatory elements in the 5'-flanking sequence of the mouse sparc (osteonectin) gene. 
  • Evidence for the existence of renin in the heart. 
  • Evidence for the involvement of the Gli gene family in embryonic mouse lung development. 
  • Evidence for two cellular pathways of renin secretion by the mouse submandibular gland. 
  • Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. 
  • Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000. 
  • Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. 
  • Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans. 
  • Evidence that Hensen's node is a site of retinoic acid synthesis. 
  • Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse. 
  • Evidence that SOX2 overexpression is oncogenic in the lung. 
  • Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. 
  • Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development. 
  • Evidence that polyphenols do not inhibit the phospholipid scramblase TMEM16F. 
  • Evidence that the platinum-reactive methionyl residue of the alpha 2-macroglobulin receptor recognition site is not in the carboxyl-terminal receptor binding domain. 
  • Evidence that there is no direct correlation between alpha 2-adrenoceptor antagonism and inhibition of voltage-dependent sodium channels. 
  • Evidence-ranked motif identification. 
  • Evolution and development of the mammalian dentition: insights from the marsupial Monodelphis domestica. 
  • Evolution of the tenascin family--implications for function of the C-terminal fibrinogen-like domain. 
  • Evolutionarily conserved role of calcineurin in phosphodegron-dependent degradation of phosphodiesterase 4D. 
  • Evolutionary and ecological functional genomics. 
  • Ex Vivo MR Histology and Cytometric Feature Mapping Connect Three-dimensional in Vivo MR Images to Two-dimensional Histopathologic Images of Murine Sarcomas. 
  • Ex vivo expansion of murine and human hematopoietic stem cells. 
  • Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. 
  • Ex vivo pediatric brain tumors express Fas (CD95) and FasL (CD95L) and are resistant to apoptosis induction. 
  • Ex vivo spermine dialdehyde treatment prevents lethal GVHD in a murine bone marrow transplantation model. 
  • Exacerbation of established pulmonary fibrosis in a murine model by gammaherpesvirus. 
  • Exaggerated peripheral responses to catecholamines contributes to stress-induced hyperglycemia in the ob/ob mouse. 
  • Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. 
  • Exceptionally potent antispermatogenic compounds from 8-halogenation of (4aRS,5SR,9bRS)-hexahydroindeno-[1,2-c]pyridines. 
  • Exercise activates vagal induction of dopamine and attenuates systemic inflammation. 
  • Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy. 
  • Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. 
  • Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer. 
  • Exercise protects against cardiac and skeletal muscle dysfunction in a mouse model of inflammatory arthritis. 
  • Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. 
  • Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections. 
  • Exogenous PP2A inhibitor exacerbates the progression of nonalcoholic fatty liver disease via NOX2-dependent activation of miR21. 
  • Exogenous leptin enhances markers of airway fibrosis in a mouse model of chronic allergic airways disease. 
  • Exogenous pyruvate prevents stress-evoked suppression of mitogen-stimulated proliferation. 
  • Exosomal CCL2 from Tubular Epithelial Cells Is Critical for Albumin-Induced Tubulointerstitial Inflammation. 
  • Exosomes decorated with a recombinant SARS-CoV-2 receptor-binding domain as an inhalable COVID-19 vaccine. 
  • Expanded Satellite Repeats Amplify a Discrete CENP-A Nucleosome Assembly Site on Chromosomes that Drive in Female Meiosis. 
  • Expanded breadth of the T-cell response to mosaic human immunodeficiency virus type 1 envelope DNA vaccination. 
  • Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network. 
  • Expanding anti-CD38 immunotherapy for lymphoid malignancies. 
  • Expanding gliogenesis. 
  • Expansion of adult beta-cell mass in response to increased metabolic demand is dependent on HNF-4alpha. 
  • Expansion of hedgehog disrupts mesenchymal identity and induces emphysema phenotype. 
  • Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain. 
  • Expansion of the human mu-opioid receptor gene architecture: novel functional variants. 
  • Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor. 
  • Experience and activity-dependent maturation of perisomatic GABAergic innervation in primary visual cortex during a postnatal critical period. 
  • Experience-dependent modification of a central amygdala fear circuit. 
  • Experimental Models of Short Courses of Liposomal Amphotericin B for Induction Therapy for Cryptococcal Meningitis. 
  • Experimental and pan-cancer genome analyses reveal widespread contribution of acrylamide exposure to carcinogenesis in humans. 
  • Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion. 
  • Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents. 
  • Experimental chemotherapy of human medulloblastoma with classical alkylators. 
  • Experimental effects of hyperbaric oxygen on selected clostridial species. II. In-vitro studies in mice. 
  • Experimental evaluation of rodent exclusion methods to reduce hantavirus transmission to residents in a Native American community in New Mexico. 
  • Experimental models of human carcinogenesis. 
  • Experimental ocular toxocariasis: a mouse model. 
  • Experimental study of the effect of diethylstilbestrol on the development of the human female reproductive tract. 
  • Experimental validation of an inverse fluorescence Monte Carlo model to extract concentrations of metabolically relevant fluorophores from turbid phantoms and a murine tumor model. 
  • Exploitation of macrophages as a replication niche by Legionella pneumophila: response. 
  • Exploiting Pre-Existing CD4+ T Cell Help from Bacille Calmette-Guérin Vaccination to Improve Antiviral Antibody Responses. 
  • Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection. 
  • Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice. 
  • Exploring type I angiotensin (AT1) receptor functions through gene targeting. 
  • Exploring variation in binding of Protein A and Protein G to immunoglobulin type G by isothermal titration calorimetry. 
  • Exposure of cultured murine peritoneal macrophages to low concentrations of beryllium induces increases in intracellular calcium concentrations and stimulates DNA synthesis. 
  • Exposure of mice to topical bovine thrombin induces systemic autoimmunity. 
  • Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin. 
  • Exposure to hyperbaric oxygen not beneficial for murine tetanus. 
  • Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology. 
  • Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. 
  • Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel. 
  • Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor. 
  • Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam. 
  • Expression and localization of components of the histone deacetylases multiprotein repressory complexes in the mouse preimplantation embryo. 
  • Expression and modification of Hox 2.1 protein in mouse embryos. 
  • Expression and modulation of RPE cell membrane complement regulatory proteins. 
  • Expression and regulation of calcium-independent protein kinase C in NG 108-15 cell differentiation. 
  • Expression and subcellular distribution of mouse cytochrome P1-450 mRNA as determined by molecular hybridization with cloned P1-450 DNA. 
  • Expression and trafficking of placental microRNAs at the feto-maternal interface. 
  • Expression cloning of type 2 angiotension II receptor reveals a unique class of seven-transmembrane receptors. 
  • Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. 
  • Expression of C3b receptors on human be cells and myelomonocytic cells but not natural killer cells. 
  • Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody. 
  • Expression of CDK4 or CDK2 in mouse oral cavity is retained in adult pituitary with distinct effects on tumorigenesis. 
  • Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells. 
  • Expression of Ca(2+)/calmodulin-dependent protein kinase IV (caMKIV) messenger RNA during murine embryogenesis. 
  • Expression of EGF receptor and transferrin by F9 and PC13 teratocarcinoma cells. 
  • Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency (scid) mutation or X-linked immunodeficiency (xid) defect. 
  • Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression. 
  • Expression of Sry, the mouse sex determining gene. 
  • Expression of TIMP in fetal and adult mouse tissues studied by in situ hybridization. 
  • Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. 
  • Expression of a candidate sex-determining gene during mouse testis differentiation. 
  • Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2. 
  • Expression of a highly conserved anti-DNA idiotype in normal and autoimmune mice. 
  • Expression of a murine cytomegalovirus early-late protein in "latently" infected mice. 
  • Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts. 
  • Expression of an antisense transforming growth factor-beta1 transgene reduces tumorigenicity of EMT6 mammary tumor cells. 
  • Expression of c-fos in parietal endoderm, amnion and differentiating F9 teratocarcinoma cells. 
  • Expression of cadherin-11 delineates boundaries, neuromeres, and nuclei in the developing mouse brain. 
  • Expression of chimeric tRNA-driven antisense transcripts renders NIH 3T3 cells highly resistant to Moloney murine leukemia virus replication. 
  • Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant. 
  • Expression of cytokine mRNA in murine splenic dendritic cells and better induction of T cell-derived cytokines by dendritic cells than by macrophages during in vitro costimulation assay using specific antigens. 
  • Expression of ectopic heat shock protein 90 in male and female primary afferent nociceptors regulates inflammatory pain. 
  • Expression of extracellular glutathione peroxidase in human and mouse gastrointestinal tract. 
  • Expression of full-length and truncated dystrophin mini-genes in transgenic mdx mice. 
  • Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells. 
  • Expression of glucokinase in cultured human muscle cells confers insulin-independent and glucose concentration-dependent increases in glucose disposal and storage. 
  • Expression of heme oxygenase-1 can determine cardiac xenograft survival. 
  • Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes with critical stages of mammalian lung development. 
  • Expression of high mobility group protein 1 in the sera of patients and mice with systemic lupus erythematosus. 
  • Expression of homeo box genes during mouse development: a review. 
  • Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice. 
  • Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury. 
  • Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A. 
  • Expression of murine leukemia virus structural antigens on the surface of chemically induced murine sarcomas. 
  • Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells. 
  • Expression of olfactory signaling genes in the eye. 
  • Expression of recombinant human methylmalonyl-CoA mutase: in primary mut fibroblasts and Saccharomyces cerevisiae. 
  • Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice. 
  • Expression of the 71 kDa dystrophin isoform (Dp71) evaluated by gene targeting. 
  • Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth. 
  • Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. 
  • Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse. 
  • Expression of the homeobox genes Hox 2.1 and 2.6 during mouse development. 
  • Expression of the human poliovirus receptor/CD155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis. 
  • Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog. 
  • Expression of the protein tyrosine phosphatase, phosphatase of regenerating liver 1, in the outer segments of primate cone photoreceptors. 
  • Expression of tissue factor in tumor stroma correlates with progression to invasive human breast cancer: paracrine regulation by carcinoma cell-derived members of the transforming growth factor beta family. 
  • Expression of transforming growth factor beta 2 RNA during murine embryogenesis. 
  • Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells. 
  • Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis. 
  • Expression of utrophin A mRNA correlates with the oxidative capacity of skeletal muscle fiber types and is regulated by calcineurin/NFAT signaling. 
  • Expression of v-Ha-ras driven by the calcitonin/calcitonin gene-related peptide promoter: a novel transgenic murine model for medullary thyroid carcinoma. 
  • Expression profiling of a transformed thymocyte cell line undergoing maturation in vitro identifies multiple genes involved in positive selection. 
  • Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. 
  • Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells. 
  • Extending principles learned in model systems to clinical trials design. 
  • Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion. 
  • Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. 
  • Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. 
  • Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans. 
  • Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse. 
  • Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia. 
  • Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse. 
  • Extracellular superoxide dismutase overexpression protects against aging-induced cognitive impairment in mice. 
  • Extracellular superoxide dismutase protects lung development in hyperoxia-exposed newborn mice. 
  • Extracellular superoxide dismutase regulates cardiac function and fibrosis. 
  • Extracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity. 
  • Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration. 
  • Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. 
  • Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. 
  • Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. 
  • F-actin aggregates in transformed cells. 
  • FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy. 
  • FGF14 regulates presynaptic Ca2+ channels and synaptic transmission. 
  • FGF2 suppresses neuronogenesis of a cell line derived from rat olfactory epithelium. 
  • FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity. 
  • FGF21-FGFR4 signaling in cardiac myocytes promotes concentric cardiac hypertrophy in mouse models of diabetes. 
  • FGF23 induces left ventricular hypertrophy. 
  • FGF23/FGFR4-mediated left ventricular hypertrophy is reversible. 
  • FGF9 promotes survival of germ cells in the fetal testis. 
  • FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma. 
  • FGFR4 does not contribute to progression of chronic kidney disease. 
  • FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes. 
  • FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506. 
  • FMRP targets distinct mRNA sequence elements to regulate protein expression. 
  • FOXN1 compound heterozygous mutations cause selective thymic hypoplasia in humans. 
  • FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms. 
  • FRAP analysis reveals stabilization of adhesion structures in the epidermis compared to cultured keratinocytes. 
  • FRET efficiency measurement in a molecular tension probe with a low-cost frequency-domain fluorescence lifetime imaging microscope. 
  • FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. 
  • Facilitating haplotype analysis by fully automated analysis of all chromosomes in human-mouse hybrid cell lines. 
  • Facilitative glucose transporter Glut1 is actively excluded from rod outer segments. 
  • Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes. 
  • Failure of 2-deoxy-D-glucose to stimulate feeding in deermice. 
  • Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI. 
  • Failure of spermatogenesis in mouse lines deficient in the Na(+)-K(+)-2Cl(-) cotransporter. 
  • Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2. 
  • Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid. 
  • Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene. 
  • Familial polycythemia due to truncations of the erythropoietin receptor. 
  • Fas activity mediates airway inflammation during mouse adenovirus type 1 respiratory infection. 
  • Fas on renal parenchymal cells does not promote autoimmune nephritis in MRL mice. 
  • Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. 
  • Fas/FasL play a central role in pancreatitis-induced hepatocyte apoptosis. 
  • Fasciated nerve-muscle explants for in vitro comparison of magnetic and electrical neuromuscular stimulation. 
  • Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. 
  • Fast acquisition and reconstruction of optical coherence tomography images via sparse representation. 
  • Fast and robust active neuron segmentation in two-photon calcium imaging using spatiotemporal deep learning. 
  • Fast serotonin voltammetry as a versatile tool for mapping dynamic tissue architecture: I. Responses at carbon fibers describe local tissue physiology. 
  • Fast voice-coil scanning optical-resolution photoacoustic microscopy. 
  • Fasting prevents experimental murine colitis produced by dextran sulfate sodium and decreases interleukin-1 beta and insulin-like growth factor I messenger ribonucleic acid. 
  • Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. 
  • Fat hormones pull their weight in the CNS. 
  • Fat, carbohydrate, and calories in the development of diabetes and obesity in the C57BL/6J mouse. 
  • Fate Mapping In Vivo to Distinguish Bona Fide Microglia Versus Recruited Monocyte-Derived Macrophages in Retinal Disease. 
  • Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina. 
  • Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. 
  • Fatty acid desaturase activity in mature red blood cells and implications for blood storage quality. 
  • Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice. 
  • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. 
  • Fatty acid synthesis is essential for survival of Cryptococcus neoformans and a potential fungicidal target. 
  • Fatty acid transport protein 2 reprograms neutrophils in cancer. 
  • Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation. 
  • Fc-mOX40L fusion protein produces complete remission and enhanced survival in 2 murine tumor models. 
  • Fc-modified HIT-like monoclonal antibody as a novel treatment for sepsis. 
  • Fear and anxiety from principle to practice: implications for when to treat youth with anxiety disorders. 
  • Feasibility of whole-body functional mouse imaging using helical pinhole SPECT. 
  • Fecal IgA, Antigen Absorption, and Gut Microbiome Composition Are Associated With Food Antigen Sensitization in Genetically Susceptible Mice. 
  • Feedback in the brainstem: an excitatory disynaptic pathway for control of whisking. 
  • Feedforward mechanisms of cross-orientation interactions in mouse V1. 
  • Feeding diversified protein sources exacerbates hepatic insulin resistance via increased gut microbial branched-chain fatty acids and mTORC1 signaling in obese mice. 
  • Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV. 
  • Female gender, estrogen loss, and Sub-RPE deposit formation in aged mice. 
  • Female steroid hormones use signal transducers and activators of transcription protein-mediated pathways to modulate the expression of T-bet in epithelial cells: a mechanism for local immune regulation in the human reproductive tract. 
  • Fenestrations of sarcoplasmic reticulum. Delineation by lanthanum acting as a fortuitous tracer and in situ negative stain. 
  • Fenofibrate rapidly decreases hepatic lipid and glycogen storage in neonatal mice with glycogen storage disease type Ia. 
  • Ferric citrate reduces fibroblast growth factor 23 levels and improves renal and cardiac function in a mouse model of chronic kidney disease. 
  • Ferroptotic stress promotes the accumulation of pro-inflammatory proximal tubular cells in maladaptive renal repair. 
  • Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium. 
  • Fetal alveolar epithelial cells contain [D-Ala(2)]-deltorphin I-like immunoreactivity: delta- and mu-opiate receptors mediate opposite effects in developing lung. 
  • Fetal and adult hematopoietic stem cells give rise to distinct T cell lineages in humans. 
  • Fetal antisense oligonucleotide therapy for congenital deafness and vestibular dysfunction. 
  • Fetal brain subdivisions defined by R- and E-cadherin expressions: evidence for the role of cadherin activity in region-specific, cell-cell adhesion. 
  • Fetal development of subcutaneous white adipose tissue is dependent on Zfp423. 
  • Fetal exposure to the maternal microbiota in humans and mice. 
  • Fetal mast cells mediate postnatal allergic responses dependent on maternal IgE. 
  • Fgf8 is required for anterior heart field development. 
  • Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. 
  • Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. 
  • Fiber-optic detector for real time dosimetry of a micro-planar x-ray beam. 
  • Fiber-optic stethoscope: a cardiac monitoring and gating system for magnetic resonance microscopy. 
  • Fibrinogen-Coated Albumin Nanospheres Prevent Thrombocytopenia-Related Bleeding. 
  • Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. 
  • Fibroblast growth factor 21 mediates specific glucagon actions. 
  • Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease. 
  • Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. 
  • Fibroblast growth factor blocks Sonic hedgehog signaling in neuronal precursors and tumor cells. 
  • Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. 
  • Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias. 
  • Fibroblast growth factor homologous factors modulate cardiac calcium channels. 
  • Fibroblast growth factor homologous factors tune arrhythmogenic late NaV1.5 current in calmodulin binding-deficient channels. 
  • Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination. 
  • Fibroblast growth factor receptor 4: the missing link between chronic kidney disease and FGF23-induced left ventricular hypertrophy? 
  • Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone. 
  • Fibrogenesis in pancreatic cancer is a dynamic process regulated by macrophage-stellate cell interaction. 
  • Fibronectin Extra Domain A Promotes Liver Sinusoid Repair following Hepatectomy. 
  • Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing. 
  • Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. 
  • Fibulin-3 is a novel TGF-β pathway inhibitor in the breast cancer microenvironment. 
  • Finale: the last minutes of Smads. 
  • Fine mapping of a putative rd cDNA and its co-segregation with rd expression. 
  • Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination. 
  • First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. 
  • First in human dose calculation of a single-chain bispecific antibody targeting glioma using the MABEL approach. 
  • Fish oil feeding modulates leukotriene production in murine lupus nephritis. 
  • Fish oil slows prostate cancer xenograft growth relative to other dietary fats and is associated with decreased mitochondrial and insulin pathway gene expression. 
  • Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination. 
  • Flavanones structure-related inhibition on TPA-induced tumor promotion through suppression of extracellular signal-regulated protein kinases: involvement of prostaglandin E2 in anti-promotive process. 
  • Flavivirus serocomplex cross-reactive immunity is protective by activating heterologous memory CD4 T cells. 
  • Flavonoids. 8. Synthesis and antifertility and estrogen receptor binding activities of coumarins and delta3-isoflavenes. 
  • Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. 
  • Flow Cytometric Identification of Tumor-Infiltrating Lymphocytes from Glioblastoma. 
  • Flow Cytometry for the Immunotoxicologist. 
  • Flow cytometric detection of lymphocyte proliferation in eyes with immunogenic inflammation. 
  • Flow cytometry sorting of recombinant mycobacterial species yields bacterial clones with enhanced insert expression. 
  • Flow velocity in the superficial lymphatic network of the mouse tail. 
  • Flow-dependent epigenetic DNA methylation regulates endothelial gene expression and atherosclerosis 
  • Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance. 
  • Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma. 
  • Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties. 
  • Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. 
  • Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients. 
  • Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin. 
  • Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo. 
  • Fluorescence-based isolation of bacterial genes expressed within host cells. 
  • Fluorescent probes that stain living nerve terminals. 
  • Fluorine-18 Labeling of the HER2-Targeting Single-Domain Antibody 2Rs15d Using a Residualizing Label and Preclinical Evaluation. 
  • Fluorine-18 Labeling of the MDM2 Inhibitor RG7388 for PET Imaging: Chemistry and Preliminary Evaluation. 
  • Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection. 
  • Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation. 
  • Fluorine-18 labeling of monoclonal antibodies and fragments with preservation of immunoreactivity. 
  • Fluorine-18-labeled [Nle4,D-Phe7]-alpha-MSH, an alpha-melanocyte stimulating hormone analogue. 
  • Fluorine-18-labeled monoclonal antibody fragments: a potential approach for combining radioimmunoscintigraphy and positron emission tomography. 
  • Fluoxetine Maintains a State of Heightened Responsiveness to Motor Training Early After Stroke in a Mouse Model. 
  • Fluvastatin downregulates VEGF-A expression in TNF-α-induced retinal vessel tortuosity. 
  • Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation. 
  • Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis. 
  • Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations. 
  • Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. 
  • Food reward in the absence of taste receptor signaling. 
  • Food-Grade TiO₂ Particles Generate Intracellular Superoxide and Alter Epigenetic Modifiers in Human Lung Cells. 
  • Force fluctuations in three-dimensional suspended fibroblasts. 
  • Force plate for measuring the ground reaction forces in small animal locomotion. 
  • Force-frequency effect is a powerful determinant of myocardial contractility in the mouse. 
  • Formation of DNA-protein cross-links in cultured mammalian cells upon treatment with iron ions. 
  • Formation of Rathke's pouch requires dual induction from the diencephalon. 
  • Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity. 
  • Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact. 
  • Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes. 
  • Formulations which increase the size of lipoplexes prevent serum-associated inhibition of transfection. 
  • Four-Point Bending Testing for Mechanical Assessment of Mouse Bone Structural Properties. 
  • Four-dimensional MR microscopy of the mouse heart using radial acquisition and liposomal gadolinium contrast agent. 
  • Four-dimensional MRI of renal function in the developing mouse. 
  • Four-dimensional analysis of vascularization during primary development of an organ, the gonad. 
  • FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. 
  • FoxJ1-dependent gene expression is required for differentiation of radial glia into ependymal cells and a subset of astrocytes in the postnatal brain. 
  • FoxO-dependent regulation of diacylglycerol kinase α gene expression. 
  • FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. 
  • Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation. 
  • Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence. 
  • Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. 
  • Frame-Hydrogel Methodology for Engineering Highly Functional Cardiac Tissue Constructs. 
  • Framework Mutations of the 10-1074 bnAb Increase Conformational Stability, Manufacturability, and Stability While Preserving Full Neutralization Activity. 
  • Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K. 
  • Frequent expression of human carcinoma-associated antigen, a mucin-type glycoprotein, in cells of prostatic carcinoma. 
  • From breast to the brain: unraveling the puzzle of metastasis organotropism. 
  • From embryo to ethics: a career in science and social responsibility. An interview with Anne McLarne [by Brigid Hogan]. 
  • From embryo to teratocarcinoma in tissue culture. 
  • From the yolk sac to the spleen: New roles for Notch in regulating hematopoiesis. 
  • Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation. 
  • Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways. 
  • Fructose consumption as a risk factor for non-alcoholic fatty liver disease. 
  • Fulfilling Koch's postulates of autoimmunity: anti-NR2 antibodies in mice and men. 
  • Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling. 
  • Full genetic rescue of adenosine deaminase-deficient mice through introduction of the human gene. 
  • Full-length dystrophin restoration via targeted exon integration by AAV-CRISPR in a humanized mouse model of Duchenne muscular dystrophy. 
  • Fully deleted adenovirus persistently expressing GAA accomplishes long-term skeletal muscle glycogen correction in tolerant and nontolerant GSD-II mice. 
  • Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. 
  • Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize. 
  • Function and regulation of calmodulin in endocrine cells. 
  • Function in athymic nude mice of parathyroid heterografts from patients with primary hyperparathyroidism and secondary hyperparathyroidism. 
  • Function of nuclear factor kappaB in pancreatic cancer metastasis. 
  • Function of tau protein in adult newborn neurons. 
  • Function of the thioredoxin proteins in Cryptococcus neoformans during stress or virulence and regulation by putative transcriptional modulators. 
  • Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2α Signaling as a Generalizable Mechanism for Dystonia. 
  • Functional Interplay between Histone H2B ADP-Ribosylation and Phosphorylation Controls Adipogenesis. 
  • Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate resting Ca2+ influx and muscle fatigue. 
  • Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice. 
  • Functional analysis of a mammalian odorant receptor subfamily. 
  • Functional analysis of myocardial performance in murine hearts overexpressing the human beta 2-adrenergic receptor. 
  • Functional analysis of novel SNPs and mutations in human and mouse genomes. 
  • Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. 
  • Functional analysis of the interface between the tandem C2 domains of synaptotagmin-1. 
  • Functional analysis of the putative integrin recognition motif on adeno-associated virus 9. 
  • Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice. 
  • Functional and molecular characterization of human monoclonal antibody reactive with the immunodominant region of HIV type 1 glycoprotein 41. 
  • Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif. 
  • Functional characteristics and survival requirements of memory CD4+ T lymphocytes in vivo. 
  • Functional comparison of RGS9 splice isoforms in a living cell. 
  • Functional complementation between FADD and RIP1 in embryos and lymphocytes. 
  • Functional consequences of altering myocardial adrenergic receptor signaling. 
  • Functional differences between human and bovine immunodeficiency virus Tat transcription factors. 
  • Functional diversity of notch family genes in fetal lung development. 
  • Functional domain and motif analyses of androgen receptor coregulator ARA70 and its differential expression in prostate cancer. 
  • Functional epialleles at an endogenous human centromere. 
  • Functional evaluation of nonphagocytic NAD(P)H oxidases. 
  • Functional evolution of mammalian odorant receptors. 
  • Functional expression of Mammalian odorant receptors. 
  • Functional expression of sodium-glucose transporters in cancer. 
  • Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae. 
  • Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. 
  • Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents. 
  • Functional imaging of tumor vasculature using iodine and gadolinium-based nanoparticle contrast agents: a comparison of spectral micro-CT using energy integrating and photon counting detectors. 
  • Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. 
  • Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. 
  • Functional neuroimaging using ultrasonic blood-brain barrier disruption and manganese-enhanced MRI. 
  • Functional organization of the genome may shape the species boundary in the house mouse. 
  • Functional photoacoustic microscopy of diabetic vasculature. 
  • Functional photoacoustic microscopy of pH. 
  • Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. 
  • Functional replacement of the mouse E2A gene with a human HEB cDNA. 
  • Functional screen identifies kinases driving prostate cancer visceral and bone metastasis. 
  • Functional selection of protease inhibitory antibodies. 
  • Functional specialization of mouse higher visual cortical areas. 
  • Functional transient receptor potential vanilloid 1 and transient receptor potential vanilloid 4 channels along different segments of the renal vasculature. 
  • Functional vagotopy in the cervical vagus nerve of the domestic pig: implications for the study of vagus nerve stimulation. 
  • Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder. 
  • Functional, non-clonal IgMa-restricted B cell receptor interactions with the HIV-1 envelope gp41 membrane proximal external region. 
  • Functionally Overlapping Variants Control Tuberculosis Susceptibility in Collaborative Cross Mice. 
  • Functionally graded multilayer scaffolds for in vivo osteochondral tissue engineering. 
  • Functionally rodless mice: transgenic models for the investigation of cone function in retinal disease and therapy. 
  • Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. 
  • Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair. 
  • Functions of skin-resident γδ T cells. 
  • Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation. 
  • Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models. 
  • Further characterization of the oncornavirus inactivating factor in normal mouse serum. 
  • Further characterization of the platinum-reactive component of the alpha 2-macroglobulin-receptor recognition site. 
  • Further studies of a macrophage chemotaxis inhibitor (MCI) produced by neoplasms: murine tumors free of lactic dehydrogenase virus produce MCI. 
  • Fusigenic viral liposome for gene therapy in cardiovascular diseases. 
  • Fusion of fibroblast growth factor 21 to a thermally responsive biopolymer forms an injectable depot with sustained anti-diabetic action. 
  • Fusion of the termini of the murine cytomegalovirus genome after infection. 
  • Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth. 
  • Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. 
  • Future of early detection of lung cancer: the role of mouse models. 
  • Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. 
  • G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis. 
  • G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. 
  • G protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice. 
  • G protein- and β-arrestin Signaling Profiles of Endothelin Derivatives at the Type A Endothelin Receptor. 
  • G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. 
  • G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning. 
  • G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. 
  • G protein-coupled receptor kinase 3 modulates mesenchymal stem cell proliferation and differentiation through sphingosine-1-phosphate receptor regulation. 
  • G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation. 
  • G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses. 
  • G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors. 
  • G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis. 
  • G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency. 
  • G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. 
  • G-protein signaling modulator-3, a gene linked to autoimmune diseases, regulates monocyte function and its deficiency protects from inflammatory arthritis. 
  • G-protein-coupled receptor function in heart failure. 
  • G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. 
  • G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer. 
  • G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons. 
  • GABA receptor-mediated chloride transport in a "cell-free" membrane preparation from brain. 
  • GABA signaling promotes synapse elimination and axon pruning in developing cortical inhibitory interneurons. 
  • GABAergic pathway from zona incerta to neocortex: clarification. 
  • GAD67-mediated GABA synthesis and signaling regulate inhibitory synaptic innervation in the visual cortex. 
  • GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts. 
  • GATA4 and the two sides of gene expression reprogramming. 
  • GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. 
  • GB virus type C envelope protein E2 elicits antibodies that react with a cellular antigen on HIV-1 particles and neutralize diverse HIV-1 isolates. 
  • GD3 expression by cultured human tumor cells of neuroectodermal origin. 
  • GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo. 
  • GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. 
  • GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling. 
  • GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. 
  • GIPR Is Predominantly Localized to Nonadipocyte Cell Types Within White Adipose Tissue. 
  • GIT1 regulates synaptic structural plasticity underlying learning. 
  • GLP toxicology study of a fully-human T cell redirecting CD3:EGFRvIII binding immunotherapeutic bispecific antibody. 
  • GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice. 
  • GLUT1 Expression in Tumor-Associated Neutrophils Promotes Lung Cancer Growth and Resistance to Radiotherapy. 
  • GMab-1, a high-affinity anti-3'-isoLM1/3',6'-isoLD1 IgG monoclonal antibody, raised in lacto-series ganglioside-defective knockout mice. 
  • GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers. 
  • GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo. 
  • GPER1 is required to protect fetal health from maternal inflammation. 
  • GPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure. 
  • GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. 
  • GPR37 regulates macrophage phagocytosis and resolution of inflammatory pain. 
  • GPR54 is a target for suppression of metastasis in endometrial cancer. 
  • GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain. 
  • GREAT improves functional interpretation of cis-regulatory regions. 
  • GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells. 
  • GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression. 
  • GRP94-associated enzymatic activities. Resolution by chromatographic fractionation. 
  • GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide production. 
  • GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice. 
  • GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome. 
  • GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. 
  • Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. 
  • Gadolinium-conjugated gold nanoshells for multimodal diagnostic imaging and photothermal cancer therapy. 
  • Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain. 
  • Galbraith Award: simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthase. 
  • Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms. 
  • Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems. 
  • Gallbladder glycoprotein secretion in mice with hemolytic anemia and pigment gallstones. 
  • Galphaq-dependent signaling cascades stimulate water-seeking behavior. 
  • Galphaz negatively regulates insulin secretion and glucose clearance. 
  • Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells. 
  • Gamma interferon-induced inhibition of Toxoplasma gondii in astrocytes is mediated by IGTP. 
  • Gamma-globin gene promoter elements required for interaction with globin enhancers. 
  • Gamma-irradiation reduces the allogenicity of donor corneas. 
  • Gammaherpesvirus modulation of mouse adenovirus type 1 pathogenesis. 
  • Gammaherpesvirus-induced lung pathology is altered in the absence of macrophages. 
  • Ganglioside mapping of a human medulloblastoma xenograft. 
  • Gap Junctions Contribute to Differential Light Adaptation across Direction-Selective Retinal Ganglion Cells. 
  • Garlic accelerates red blood cell turnover and splenic erythropoietic gene expression in mice: evidence for erythropoietin-independent erythropoiesis. 
  • Gastroesophageal reflux-associated aspiration alters the immune response in asthma. 
  • Gastrointestinal microbiota alteration induced by Mucor circinelloides in a murine model. 
  • Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy. 
  • Gelatin-embedded cell-polymer constructs for histological cryosectioning. 
  • Gender and estrogen supplementation increases severity of experimental choroidal neovascularization. 
  • Gender differences in human immunodeficiency virus type 1-specific CD8 responses in the reproductive tract and colon following nasal peptide priming and modified vaccinia virus Ankara boosting. 
  • Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor. 
  • Gene Delivery of a Caspase Activation and Recruitment Domain Improves Retinal Pigment Epithelial Function and Modulates Inflammation in a Mouse Model with Features of Dry Age-Related Macular Degeneration. 
  • Gene Expression Profile of Dendritic Cell-Tumor Cell Hybrids Determined by Microarrays and Its Implications for Cancer Immunotherapy. 
  • Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain. 
  • Gene Expression of Diverse Cryptococcus Isolates during Infection of the Human Central Nervous System. 
  • Gene Therapy for Modulation of T-Cell-Mediated Immune Response Provoked by Corneal Transplantation. 
  • Gene and protein expression pilot profiling and biomarkers in an experimental mouse model of hypertensive glaucoma. 
  • Gene by sex interaction in the etiology of coronary heart disease and the preceding metabolic syndrome. 
  • Gene conversion in the absence of reciprocal recombination. 
  • Gene delivery through cell culture substrate adsorbed DNA complexes 
  • Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. 
  • Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. 
  • Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. 
  • Gene expression analysis of purified hematopoietic stem cells and committed progenitors. 
  • Gene expression phenotypes of oncogenic signaling pathways. 
  • Gene expression phenotypic models that predict the activity of oncogenic pathways. 
  • Gene expression profiles linked to AT1 angiotensin receptors in the kidney. 
  • Gene expression profiles of RAW264.7 macrophages stimulated with preparations of LPS differing in isolation and purity. 
  • Gene expression profiling of familial and sporadic interstitial pneumonia. 
  • Gene expression profiling of mouse bladder inflammatory responses to LPS, substance P, and antigen-stimulation. 
  • Gene expression profiling reveals progesterone-mediated cell cycle and immunoregulatory roles of Hoxa-10 in the preimplantation uterus. 
  • Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. 
  • Gene expression signatures that predict radiation exposure in mice and humans. 
  • Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. 
  • Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins. 
  • Gene silencing using RNA interference in embryonic stem cells. 
  • Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. 
  • Gene targeting in physiological investigations: studies of the renin-angiotensin system. 
  • Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases 
  • Gene targeting. Getting nearer the mark. 
  • Gene therapies that restore dystrophin expression for the treatment of Duchenne muscular dystrophy. 
  • Gene therapy in tissue-engineered blood vessels. 
  • Gene transfer to the thymus. A means of abrogating the immune response to recombinant adenovirus. 
  • Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease. 
  • General anesthetics activate a potent central pain-suppression circuit in the amygdala. 
  • General olfactory sensitivity database (GOSdb): candidate genes and their genomic variations. 
  • Generation and Characterization of a Cell Type-Specific, Inducible Cre-Driver Line to Study Olfactory Processing. 
  • Generation and analysis of partially haploid cells with Cre-mediated chromosome deletion in the lymphoid system. 
  • Generation and behavioral characterization of beta-catenin forebrain-specific conditional knock-out mice. 
  • Generation and characterization of Tmeff2 mutant mice. 
  • Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology. 
  • Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin. 
  • Generation and characterization of anti-Adeno-associated virus serotype 8 (AAV8) and anti-AAV9 monoclonal antibodies. 
  • Generation and characterization of mice lacking gastrin-releasing peptide receptor. 
  • Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma. 
  • Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. 
  • Generation of CAR T cells for adoptive therapy in the context of glioblastoma standard of care. 
  • Generation of CD8+ T-cell responses by a recombinant nonpathogenic Mycobacterium smegmatis vaccine vector expressing human immunodeficiency virus type 1 Env. 
  • Generation of Dhx9-deficient clones in T-cell development with a mitotic recombination technique. 
  • Generation of a Listeria vaccine strain by enhanced caspase-1 activation. 
  • Generation of a Magoh conditional allele in mice. 
  • Generation of a Mouse Full-length Balancer with Versatile Cassette-shuttling Selection Strategy. 
  • Generation of a loxP flanked bmp4loxP-lacZ allele marked by conditional lacZ expression. 
  • Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity. 
  • Generation of a polyclonal Fab phage display library to the protozoan parasite Cryptosporidium parvum. 
  • Generation of a polyclonal fab phage display library to the human breast carcinoma cell line BT-20. 
  • Generation of anti-idiotypic reagents in the EGFRvIII tumor-associated antigen system. 
  • Generation of bone marrow and fetal liver chimeric mice. 
  • Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin. 
  • Generation of mucosal anti-human immunodeficiency virus type 1 T-cell responses by recombinant Mycobacterium smegmatis. 
  • Generation of neutralizing activity against human immunodeficiency virus type 1 in serum by antibody gene transfer. 
  • Generation of normal lymphocyte populations following transplantation of adenosine-deaminase-deficient fetal liver cells. 
  • Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice. 
  • Generation of primary tumor-specific cytotoxic T lymphocytes from autologous and human lymphocyte antigen class I-matched allogeneic peripheral blood lymphocytes by B7 gene-modified melanoma cells. 
  • Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice. 
  • Generation of reovirus core-like particles in cells infected with hybrid vaccinia viruses that express genome segments L1, L2, L3, and S2. 
  • Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: evidence that the heart has the capacity to synthesize and secrete lipoproteins. 
  • Genes for the neuronal immunoglobulin domain cell adhesion molecules neurofascin and Nr-CAM map to mouse chromosomes 1 and 12 and homologous human chromosomes. 
  • Genes that modify the hemochromatosis phenotype in mice. 
  • Genesis of the monophasic action potential: role of interstitial resistance and boundary gradients. 
  • Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension. 
  • Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders. 
  • Genetic Dissection of Cardiac Remodeling in an Isoproterenol-Induced Heart Failure Mouse Model. 
  • Genetic Screen in Chlamydia muridarum Reveals Role for an Interferon-Induced Host Cell Death Program in Antimicrobial Inclusion Rupture. 
  • Genetic Single Neuron Anatomy Reveals Fine Granularity of Cortical Axo-Axonic Cells. 
  • Genetic Variation in Surfactant Protein-A2 Delays Resolution of Eosinophilia in Asthma. 
  • Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells. 
  • Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. 
  • Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. 
  • Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity. 
  • Genetic analysis of susceptibility to Chlamydia trachomatis in mouse. 
  • Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease. 
  • Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice. 
  • Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma. 
  • Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. 
  • Genetic and pharmacological validation of TAK1 inhibition in macrophages as a therapeutic strategy to effectively inhibit TNF secretion. 
  • Genetic approaches to neural circuits in the mouse. 
  • Genetic association study of adiposity and melanocortin-4 receptor (MC4R) common variants: replication and functional characterization of non-coding regions. 
  • Genetic background influences cardiac phenotype in murine chronic kidney disease. 
  • Genetic basis of murine responses to hyperoxia-induced lung injury. 
  • Genetic characterization of a missense mutation in the X-linked TAF7L gene identified in an oligozoospermic man†. 
  • Genetic control of blood pressure and the angiotensinogen locus. 
  • Genetic control of inflammatory arthritis and glomerulonephritis in congenic lpr mice and their F1 hybrids. 
  • Genetic control of inflammatory arthritis in congenic lpr mice. 
  • Genetic control of peripheral leukocyte response to endotoxin in mice. 
  • Genetic control of the immune response to nuclease. V. Genetic linkage and strain distribution of anti-nuclease idiotypes. 
  • Genetic control of the immune response to staphylococcal nuclease in mice. 
  • Genetic control of the immune response to staphylococcal nuclease. IX. Recombination between genes determining BALB/c antinuclease idiotypes and the heavy chain allotype locus. 
  • Genetic control of the immune response to staphylococcal nuclease. VII. Role of non-H2-linked genes in the control of the anti-nuclease antibody response. 
  • Genetic control of the immune response to staphylococcal nuclease. VIII. Mapping of genes for antibodies to different antigenic regions of nuclease. 
  • Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells. 
  • Genetic deletion of A2A adenosine receptors in the striatum selectively impairs habit formation 
  • Genetic deletion of Rgs12 in mice affects serotonin transporter expression and function in vivo and ex vivo. 
  • Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). 
  • Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice. 
  • Genetic disruption of WASHC4 drives endo-lysosomal dysfunction and cognitive-movement impairments in mice and humans. 
  • Genetic dissection of rod and cone pathways in the dark-adapted mouse retina. 
  • Genetic dissection of the glutamatergic neuron system in cerebral cortex. 
  • Genetic dissection of the mouse CNS using magnetic resonance microscopy. 
  • Genetic dissection of the mouse brain using high-field magnetic resonance microscopy. 
  • Genetic elimination of α3(IV) collagen fails to rescue anti-collagen B cells. 
  • Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function. 
  • Genetic factors determine the contribution of leukotrienes to acute inflammatory responses. 
  • Genetic immunization with LYVE-1 cDNA yields function-blocking antibodies against native protein. 
  • Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. 
  • Genetic induction of tumorigenesis in swine. 
  • Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb. 
  • Genetic labeling of neurons in mouse brain. 
  • Genetic manipulation of the renin-angiotensin system. 
  • Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively. 
  • Genetic modeling of Ras-induced human rhabdomyosarcoma. 
  • Genetic modeling of human rhabdomyosarcoma. 
  • Genetic models reveal origin, persistence and non-redundant functions of IL-17-producing γδ T cells. 
  • Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. 
  • Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy. 
  • Genetic modifiers of the Kv beta2-null phenotype in mice. 
  • Genetic mosaics reveal both cell-autonomous and cell-nonautonomous function of murine p27Kip1. 
  • Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. 
  • Genetic pathway analysis reveals a major role for extracellular matrix organization in inflammatory and neuropathic pain. 
  • Genetic polymorphisms: a cornerstone of translational biobehavioral research. 
  • Genetic regulation of pristane-induced oil granuloma responses. 
  • Genetic resistance to infection influences a male's sexual attractiveness and modulation of testosterone. 
  • Genetic susceptibility to benzene-induced toxicity: role of NADPH: quinone oxidoreductase-1. 
  • Genetic variants on chromosome 1q41 influence ocular axial length and high myopia. 
  • Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. 
  • Genetic variation in SP-A2 leads to differential binding to Mycoplasma pneumoniae membranes and regulation of host responses. 
  • Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics. 
  • Genetically Encoded Stealth Nanoparticles of a Zwitterionic Polypeptide-Paclitaxel Conjugate Have a Wider Therapeutic Window than Abraxane in Multiple Tumor Models. 
  • Genetically Encoding Albumin Binding into Chemotherapeutic-loaded Polypeptide Nanoparticles Enhances Their Antitumor Efficacy. 
  • Genetically Engineered Nanoparticles of Asymmetric Triblock Polypeptide with a Platinum(IV) Cargo Outperforms a Platinum(II) Analog and Free Drug in a Murine Cancer Model. 
  • Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. 
  • Genetically manipulating endogenous Kras levels and oncogenic mutations in vivo influences tissue patterning of murine tumorigenesis. 
  • Genetically stable poliovirus vectors activate dendritic cells and prime antitumor CD8 T cell immunity. 
  • Genetics of parkin-linked disease. 
  • Genetics. Origin of species in overdrive. 
  • Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs. 
  • Genome accessibility is widely preserved and locally modulated during mitosis. 
  • Genome engineering: the next genomic revolution. 
  • Genome sequencing of SHH medulloblastoma predicts genotype-related response to smoothened inhibition. 
  • Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts. 
  • Genome wide analyses reveal little evidence for adaptive evolution in many plant species. 
  • Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors. 
  • Genome-wide CRISPR Screen to Identify Genes that Suppress Transformation in the Presence of Endogenous KrasG12D. 
  • Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. 
  • Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease. 
  • Genome-wide architecture of reproductive isolation in a naturally occurring hybrid zone between Mus musculus musculus and M. m. domesticus. 
  • Genome-wide association of pericardial fat identifies a unique locus for ectopic fat. 
  • Genome-wide association reveals contribution of MRAS to painful temporomandibular disorder in males. 
  • Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia. 
  • Genome-wide identification of autosomal genes with allelic imbalance of chromatin state. 
  • Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. 
  • Genome-wide identification of regulatory elements in Sertoli cells. 
  • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. 
  • Genome-wide mutational signatures of aristolochic acid and its application as a screening tool. 
  • Genome-wide prediction of imprinted murine genes. 
  • Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the pancreas. 
  • Genomic Status of MET Potentiates Sensitivity to MET and MEK Inhibition in NF1-Related Malignant Peripheral Nerve Sheath Tumors. 
  • Genomic abnormalities of the murine model of Fabry disease after disease-related perturbation, a systems biology approach. 
  • Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates. 
  • Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. 
  • Genomic analysis reveals distinct mechanisms and functional classes of SOX10-regulated genes in melanocytes. 
  • Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells. 
  • Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. 
  • Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma. 
  • Genomic organization and cloning of the human homologue of murine Sipa-1. 
  • Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. 
  • Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene. 
  • Genomic size of CENP-A domain is proportional to total alpha satellite array size at human centromeres and expands in cancer cells. 
  • Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF). 
  • Genomically informed small-molecule drugs overcome resistance to a sustained-release formulation of an engineered death receptor agonist in patient-derived tumor models. 
  • Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice. 
  • Genotypic and Phenotypic Diversity among Human Isolates of Akkermansia muciniphila. 
  • Geometric calibration for a dual tube/detector micro-CT system. 
  • Geometrical differences among homologous neurons in mammals. 
  • Germ cells are not required to establish the female pathway in mouse fetal gonads. 
  • Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination. 
  • Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. 
  • Germline AGO2 mutations impair RNA interference and human neurological development. 
  • Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia. 
  • Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient. 
  • Germline sequences of V(H)7183 gene family members in C57BL/6 mice demonstrate natural selection of particular sequences during recent evolution. 
  • Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion. 
  • Gestational Stage and IFN-λ Signaling Regulate ZIKV Infection In Utero. 
  • Gestational, pathologic and biochemical differences between very long-chain acyl-CoA dehydrogenase deficiency and long-chain acyl-CoA dehydrogenase deficiency in the mouse. 
  • Getting biological about the genetics of diabetes. 
  • Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans. 
  • Gi alpha 1-mediated cardiac electrophysiological remodeling and arrhythmia in hypertrophic cardiomyopathy. 
  • Gi-biased β2AR signaling links GRK2 upregulation to heart failure. 
  • Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. 
  • Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling. 
  • Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice. 
  • Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis. 
  • Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors. 
  • Glial ankyrins facilitate paranodal axoglial junction assembly. 
  • Glial localization of antiquitin: implications for pyridoxine-dependent epilepsy. 
  • Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. 
  • Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. 
  • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. 
  • Glipizide stimulates sympathetic outflow in diabetes-prone mice. 
  • Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia. 
  • Global Motion Processing by Populations of Direction-Selective Retinal Ganglion Cells. 
  • Global analysis of gene expression in renal ischemia-reperfusion in the mouse. 
  • Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos. 
  • Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains. 
  • Global impact of RNA splicing on transcriptome remodeling in the heart. 
  • Globin attenuates the innate immune response to endotoxin. 
  • Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis. 
  • Glucagon lowers glycemia when β-cells are active. 
  • Glucagon-like peptide 2 for intestinal stem cell and Paneth cell repair during graft-versus-host disease in mice and humans. 
  • Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis. 
  • Glucocorticoid receptor triggers a reversible drug-tolerant dormancy state with acquired therapeutic vulnerabilities in lung cancer. 
  • Glucocorticoid treatment alleviates dystrophic myofiber pathology by activation of the calcineurin/NF-AT pathway. 
  • Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms. 
  • Glucose Activates Vagal Control of Hyperglycemia and Inflammation in Fasted Mice. 
  • Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues. 
  • Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter. 
  • Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation. 
  • Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. 
  • Glucose-6-phosphatase mutation G188R confers an atypical glycogen storage disease type 1b phenotype. 
  • Glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo. 
  • Glutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration. 
  • Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies. 
  • Glutaminase 2 negatively regulates the PI3K/AKT signaling and shows tumor suppression activity in human hepatocellular carcinoma. 
  • Glutamine Metabolism Regulates Proliferation and Lineage Allocation in Skeletal Stem Cells. 
  • Glutamine attenuates inflammation and NF-kappaB activation via Cullin-1 deneddylation. 
  • Glutamine attenuation of cell death and inducible nitric oxide synthase expression following inflammatory cytokine-induced injury is dependent on heat shock factor-1 expression. 
  • Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity. 
  • Glutamine in acute lung injury: the experimental model matters. 
  • Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1. 
  • Glutamine therapy improves outcome of in vitro and in vivo experimental colitis models. 
  • Glutamine's protection against cellular injury is dependent on heat shock factor-1. 
  • Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression. 
  • Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expression. 
  • Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expression. 
  • Glutathione and glutathione S-transferase in benign and malignant prostate cell lines and prostate tissues. 
  • Glutathione depletion or radiation treatment alters respiration and induces apoptosis in R3230Ac mammary carcinoma. 
  • Glutathione peroxidase-3 deficiency promotes platelet-dependent thrombosis in vivo. 
  • Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin A. 
  • Glutathione protects cardiac and skeletal muscle from cyclophosphamide-induced toxicity. 
  • Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. 
  • Glycan binding avidity determines the systemic fate of adeno-associated virus type 9. 
  • Glycated AAV vectors: chemical redirection of viral tissue tropism. 
  • Glycerol phosphate shuttle enzyme GPD2 regulates macrophage inflammatory responses. 
  • Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation. 
  • Glycogen accumulation in smooth muscle of a Pompe disease mouse model. 
  • Glycogen storage in multiple muscles of old GSD-II mice can be rapidly cleared after a single intravenous injection with a modified adenoviral vector expressing hGAA. 
  • Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. 
  • Glycogen synthase: a putative locus for diet-induced hyperglycemia. 
  • Glycogen-branching enzyme deficiency leads to abnormal cardiac development: novel insights into glycogen storage disease IV. 
  • Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas. 
  • Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production. 
  • Glycopeptide epitope facilitates HIV-1 envelope specific humoral immune responses by eliciting T cell help. 
  • Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis. 
  • Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain. 
  • Glyphosate induces benign monoclonal gammopathy and promotes multiple myeloma progression in mice. 
  • Gnao1 (G alphaO protein) is a likely genetic contributor to variation in physical dependence on opioids in mice. 
  • Gnotobiotic models for study of the microbial ecology of Clostridium difficile and Escherichia coli. 
  • Gold Nanostars: A Novel Platform for Developing 211At-Labeled Agents for Targeted Alpha-Particle Therapy. 
  • Gold nanoparticles provide bright long-lasting vascular contrast for CT imaging. 
  • Gold nanostars: surfactant-free synthesis, 3D modelling, and two-photon photoluminescence imaging. 
  • Gonadectomy prevents the increase in blood pressure and glomerular injury in angiotensin-converting enzyme 2 knockout diabetic male mice. Effects on renin-angiotensin system. 
  • Gonadotropin-releasing hormone neuronal cell lines. 
  • Gp91phox contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells. 
  • Gq signaling causes glomerular injury by activating TRPC6. 
  • Gq-dependent signaling upregulates COX2 in glomerular podocytes. 
  • Gradated assembly of multiple proteins into supramolecular nanomaterials. 
  • Graded diacylglycerol kinases α and ζ activities ensure mucosal-associated invariant T-cell development in mice. 
  • Gradients of transgene expression directed by the human myoglobin promoter in the developing mouse heart. 
  • Graft hyporeactivity induced by donor-derived dendritic cell progenitors. 
  • Graft hyporeactivity induced by immature donor-derived dendritic cells. 
  • Graft versus host disease following allogeneic bone marrow transplantation. 
  • Graft-extrinsic cells predominate in vein graft arterialization. 
  • Graft-versus-host disease prevention by rapamycin: cellular mechanisms. 
  • Graft-versus-host disease: the viewpoint from the donor T cell. 
  • Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). 
  • Granulocytes act as a niche for Mycobacterium tuberculosis growth. 
  • Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. 
  • Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus. 
  • Group VIA Ca2+-independent phospholipase A2 (iPLA2beta) and its role in beta-cell programmed cell death. 
  • Group VIA Phospholipase A2 (iPLA2β) Modulates Bcl-x 5'-Splice Site Selection and Suppresses Anti-apoptotic Bcl-x(L) in β-Cells. 
  • Growth and chemotherapeutic response in athymic mice of tumors arising from human glioma-derived cell lines. 
  • Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells. 
  • Growth factor modulation of p53-mediated growth arrest versus apoptosis. 
  • Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation. 
  • Growth factor receptors as molecular targets for cancer diagnosis and therapy. 
  • Growth factors can influence cell growth and survival through effects on glucose metabolism. 
  • Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing. 
  • Growth failure and AIDS-like cachexia syndrome in HIV-1 transgenic mice. 
  • Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice. 
  • Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I. 
  • Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. 
  • Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3. 
  • Growth inhibition of a human lung adenocarcinoma cell line by genetic complementation with chromosome 11. 
  • Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. 
  • Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8. 
  • Growth phenotypes and biosafety profiles in poliovirus-receptor transgenic mice of recombinant oncolytic polio/human rhinoviruses. 
  • Growth signaling at the nexus of stem cell life and death. 
  • Growth, morphology, and serial transplantation of anaplastic human gliomas in athymic mice. 
  • Guanine arabinoside as a bone marrow-purging agent. 
  • Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast. 
  • Guanosine triphosphate cyclohydrolase I regulates nitric oxide synthesis in renal proximal tubules. 
  • Guanosine triphosphate links MYC-dependent metabolic and ribosome programs in small-cell lung cancer. 
  • Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components. 
  • Guanylate Binding Proteins Restrict Leishmania donovani Growth in Nonphagocytic Cells Independent of Parasitophorous Vacuolar Targeting. 
  • Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. 
  • Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. 
  • Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate. 
  • Guidelines for the welfare and use of animals in cancer research. 
  • Guinea pig and bovine zeta-crystallins have distinct functional characteristics highlighting replacements in otherwise similar structures. 
  • Gustatory effects of capsaicin that are independent of TRPV1 receptors. 
  • Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. 
  • Gut barrier dysfunction in the Apc(Min/+) mouse model of colon cancer cachexia. 
  • Gut dysbiosis promotes M2 macrophage polarization and allergic airway inflammation via fungi-induced PGE₂. 
  • Gut immune maturation depends on colonization with a host-specific microbiota. 
  • Gut microbiome contributions to altered metabolism in a pig model of undernutrition. 
  • Gut microbiota from twins discordant for obesity modulate metabolism in mice. 
  • Gut-Innervating Nociceptor Neurons Regulate Peyer's Patch Microfold Cells and SFB Levels to Mediate Salmonella Host Defense. 
  • Gut-microbiota-microglia-brain interactions in Alzheimer's disease: knowledge-based, multi-dimensional characterization. 
  • Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling. 
  • Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion. 
  • Gαz regulates BDNF-induction of axon growth in cortical neurons. 
  • H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury. 
  • H-2K-, H-21- and H-2D-restricted hybridoma contact sensitivity effector cells. 
  • H1 RNA polymerase III promoter-driven expression of an RNA aptamer leads to high-level inhibition of intracellular protein activity. 
  • H1 histone and nucleosome repeat length alterations associated with the in vitro differentiation of murine embryonal carcinoma cells to extra-embryonic endoderm. 
  • H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection. 
  • HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor. 
  • HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection. 
  • HDAC inhibitor chidamide synergizes with venetoclax to inhibit the growth of diffuse large B-cell lymphoma via down-regulation of MYC, BCL2, and TP53 expression. 
  • HDAC3 sets the timer on muscle fuel switching. 
  • HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration. 
  • HDAC4 regulates muscle fiber type-specific gene expression programs. 
  • HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. 
  • HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. 
  • HDAC6 is a microtubule-associated deacetylase. 
  • HDAC6 maintains mitochondrial connectivity under hypoxic stress by suppressing MARCH5/MITOL dependent MFN2 degradation. 
  • HDAC6 modulates cell motility by altering the acetylation level of cortactin. 
  • HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. 
  • HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes. 
  • HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea. 
  • HEPSIN inhibits cell growth/invasion in prostate cancer cells. 
  • HER2 Isoforms Uniquely Program Intratumor Heterogeneity and Predetermine Breast Cancer Trajectories During the Occult Tumorigenic Phase. 
  • HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis. 
  • HER2-LAMP vaccines effectively traffic to endolysosomal compartments and generate enhanced polyfunctional T cell responses that induce complete tumor regression. 
  • HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development. 
  • HES1 is a novel downstream modifier of the SHH-GLI3 Axis in the development of preaxial polydactyly. 
  • HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism. 
  • HIF-1α in heart: protective mechanisms. 
  • HIF-1α inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation. 
  • HIF1α and HIF2α exert distinct nutrient preferences in renal cells. 
  • HIV infection and the dynamic interplay between the thymus and the peripheral T cell pool. 
  • HIV type 1 V3 region primer-induced antibody suppression is overcome by administration of C4-V3 peptides as a polyvalent immunogen. 
  • HIV vaccines. Magic of the occult? 
  • HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism. 
  • HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. 
  • HIV-1 Nef induces proliferation and anchorage-independent growth in podocytes. 
  • HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells. 
  • HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells. 
  • HIV-1 antibodies and vaccine antigen selectively interact with lipid domains. 
  • HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence. 
  • HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy. 
  • HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells. 
  • HIV-1 infection: fooling the gatekeeper. 
  • HIV-1 neutralizing monoclonal antibodies induced by a synthetic peptide. 
  • HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor. 
  • HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. 
  • HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. 
  • HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease. 
  • HNF-3 beta as a regulator of floor plate development. 
  • HNF4α regulates sulfur amino acid metabolism and confers sensitivity to methionine restriction in liver cancer. 
  • HSP90-Specific nIR Probe Identifies Aggressive Prostate Cancers: Translation from Preclinical Models to a Human Phase I Study. 
  • HSV-1 retinitis and delayed hypersensitivity in DBA/2 and C57BL/6 mice. 
  • Haem oxygenase-1 prevents cell death by regulating cellular iron. 
  • Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrast enhancement, detection sensitivity, and tissue penetration. 
  • Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration. 
  • Handheld optical-resolution photoacoustic microscopy. 
  • Haplo-insufficiency of Bcl2-associated athanogene 3 in mice results in progressive left ventricular dysfunction, β-adrenergic insensitivity, and increased apoptosis. 
  • Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. 
  • Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. 
  • Haploinsufficiency of PRR12 causes a spectrum of neurodevelopmental, eye, and multisystem abnormalities. 
  • Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons. 
  • Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development. 
  • Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure. 
  • Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. 
  • Hapten-specific T cell response to 4-hydroxy-3-nitrophenyl acetyl. X. Characterization of distinct T cell subsets mediating cutaneous sensitivity responses. 
  • Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. 
  • Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VI. Evidence for different T cell receptors in cells that mediate H-21-restricted and H-2D-restricted cutaneous sensitivity responses. 
  • Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VIII. Suppressor cell pathways in cutaneous sensitivity responses. 
  • Haptoglobin modifies the hemochromatosis phenotype in mice. 
  • Harboring of particulate allergens within secretory compartments by mast cells following IgE/FcepsilonRI-lipid raft-mediated phagocytosis. 
  • Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. 
  • Harnessing calcineurin-FK506-FKBP12 crystal structures from invasive fungal pathogens to develop antifungal agents. 
  • Harnessing the power of cell-penetrating peptides: activatable carriers for targeting systemic delivery of cancer therapeutics and imaging agents. 
  • Harnessing virus tropism for dendritic cells for vaccine design. 
  • Have gene knockouts caused evolutionary reversals in the mammalian first arch? 
  • Heart and lung disease in engineered mice. 
  • Heart hypertrophy during pregnancy: a better functioning heart? 
  • Heart size-independent analysis of myocardial function in murine pressure overload hypertrophy. 
  • Heat shock protein 70-binding protein 1 is highly expressed in high-grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces. 
  • Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts. 
  • Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity. 
  • Heat-induced gene expression as a novel targeted cancer gene therapy strategy. 
  • Heating or freezing bone. Effects on angiogenesis induction and growth potential in mice. 
  • Hedgehog Signaling Regulates Metabolism and Polarization of Mammary Tumor-Associated Macrophages. 
  • Hedgehog and Notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas. 
  • Hedgehog controls hepatic stellate cell fate by regulating metabolism. 
  • Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis. 
  • Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. 
  • Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth. 
  • Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer. 
  • Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X protein. 
  • Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice. 
  • Hedgehog signaling maintains resident hepatic progenitors throughout life. 
  • Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. 
  • Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation. 
  • Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer. 
  • Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. 
  • Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. 
  • Heightened potency of human pluripotent stem cell lines created by transient BMP4 exposure. 
  • Hel-N1, an RNA-binding protein, is a ligand for an A + U rich region of the GLUT1 3' UTR. 
  • Helicobacter infection decreases reproductive performance of IL10-deficient mice. 
  • Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice. 
  • Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis. 
  • Helminth-induced reprogramming of the stem cell compartment inhibits type 2 immunity. 
  • Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. 
  • Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin. 
  • Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses. 
  • Hematopoietic Wnts Modulate Endochondral Ossification During Fracture Healing. 
  • Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation. 
  • Hematopoietic stem cells convert into liver cells within days without fusion. 
  • Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. 
  • Heme Oxygenase-1/Carbon Monoxide System and Embryonic Stem Cell Differentiation and Maturation into Cardiomyocytes. 
  • Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. 
  • Heme oxygenase 1 is required for mammalian iron reutilization. 
  • Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. 
  • Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis. 
  • Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. 
  • Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway. 
  • Hemochromatosis drives acute lethal intestinal responses to hyperyersiniabactin-producing Yersinia pseudotuberculosis. 
  • Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension. 
  • Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity. 
  • Hemodynamic effects of vasorelaxant compounds in mice lacking one, two or all three angiotensin II receptors. 
  • Hemoglobin conformation couples erythrocyte S-nitrosothiol content to O2 gradients. 
  • Hemorrhage and thrombus formation in early experimental osteonecrosis. 
  • HepaCAM controls astrocyte self-organization and coupling. 
  • Heparan sulfate is a plasma biomarker of acute cellular allograft rejection. 
  • Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation. 
  • Heparin binding EGF is necessary for vasospastic response to endothelin. 
  • Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. 
  • Heparin modifies the immunogenicity of positively charged proteins. 
  • Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA. 
  • Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly. 
  • Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity. 
  • Hepatic GALE Regulates Whole-Body Glucose Homeostasis by Modulating Tff3 Expression. 
  • Hepatic HKDC1 Expression Contributes to Liver Metabolism. 
  • Hepatic IRF3 fuels dysglycemia in obesity through direct regulation of Ppp2r1b. 
  • Hepatic Mitochondrial SAB Deletion or Knockdown Alleviates Diet-Induced Metabolic Syndrome, Steatohepatitis, and Hepatic Fibrosis. 
  • Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis. 
  • Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice. 
  • Hepatic angiomyolipoma and hepatic stellate cells share a similar gene expression profile. 
  • Hepatic fibrogenesis requires sympathetic neurotransmitters. 
  • Hepatic fibrosis associated with aging in four stocks of mice. 
  • Hepatic hexokinase domain containing 1 (HKDC1) improves whole body glucose tolerance and insulin sensitivity in pregnant mice. 
  • Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition? 
  • Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. 
  • Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa). 
  • Hepatic receptor that specifically binds oligosaccharides containing fucosyl alpha1 leads to 3 N-acetylglucosamine linkages. 
  • Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO. 
  • Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice. 
  • Hepatorenal correction in murine glycogen storage disease type I with a double-stranded adeno-associated virus vector. 
  • Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. 
  • Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. 
  • Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin. 
  • Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice. 
  • Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors. 
  • Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. 
  • Heritable vaginal bacteria influence immune tolerance and relate to early-life markers of allergic sensitization in infancy. 
  • Heroin neuroteratogenicity: tar