Mice

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  Subject Areas on Research

  • "Model" behavior. 
  • "Silent" NMDA Synapses Enhance Motion Sensitivity in a Mature Retinal Circuit. 
  • "The very pulse of the machine": the tuberculous granuloma in motion. 
  • "To learn, you must pay attention." Molecular insights into teachers' wisdom. 
  • 'Chimeric' grafts assembled from multiple allodisparate donors enjoy enhanced transplant survival. 
  • 'Coreceptor tuning': cytokine signals transcriptionally tailor CD8 coreceptor expression to the self-specificity of the TCR. 
  • (2S)-2-(3-(1-Carboxy-5-(4-211At-Astatobenzamido)Pentyl)Ureido)-Pentanedioic Acid for PSMA-Targeted α-Particle Radiopharmaceutical Therapy. 
  • (4-[18F]fluoro-3-iodobenzyl)guanidine, a potential MIBG analogue for positron emission tomography. 
  • (Aryloxy)aryl semicarbazones and related compounds: a novel class of anticonvulsant agents possessing high activity in the maximal electroshock screen. 
  • 1 alpha,25 Dihydroxyvitamin D3 and mononuclear phagocytes: enhancement of mouse macrophage and human monocyte hydrogen peroxide production without alteration of tumor cytolysis. 
  • 1,2,4-Trioxanes as potential antimalarial agents. 
  • 1-(m-[211At]astatobenzyl)guanidine: synthesis via astato demetalation and preliminary in vitro and in vivo evaluation. 
  • 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced astrogliosis does not require activation of ornithine decarboxylase. 
  • 12-O-tetradecanoylphorbol-13-acetate and UV radiation-induced nucleoside diphosphate protein kinase B mediates neoplastic transformation of epidermal cells. 
  • 125I-labeled anti-epidermal growth factor receptor-vIII single-chain Fv exhibits specific and high-level targeting of glioma xenografts. 
  • 131I-labeled Anti-HER2 Camelid sdAb as a Theranostic Tool in Cancer Treatment. 
  • 14-3-3 Proteins regulate mutant LRRK2 kinase activity and neurite shortening. 
  • 17beta-estradiol differentially activates mitogen-activated protein-kinases and improves survival following reperfusion injury of reduced-size liver in mice. 
  • 2'-OMe-phosphorodithioate-modified siRNAs show increased loading into the RISC complex and enhanced anti-tumour activity. 
  • 2-O, 3-O-desulfated heparin inhibits neutrophil elastase-induced HMGB-1 secretion and airway inflammation. 
  • 2.6 Mb YAC contig of the human X inactivation center region in Xq13: physical linkage of the RPS4X, PHKA1, XIST and DXS128E genes. 
  • 211At radiocolloid therapy: further observations and comparison with radiocolloids of 32P, 165Dy, and 90Y. 
  • 211At- and 131I-labeled bisphosphonates with high in vivo stability and bone accumulation. 
  • 27-Hydroxycholesterol links hypercholesterolemia and breast cancer pathophysiology. 
  • 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis. 
  • 3,4-Diaminopyridine (DAP) in the treatment of Lambert-Eaton myasthenic syndrome (LEMS). 
  • 3-D Adaptive Sparsity Based Image Compression With Applications to Optical Coherence Tomography. 
  • 3-Halo-5,7-dimethylpyrazolo [1,5-a]pyrimidines, a nonbenzodiazepinoid class of antianxiety agents devoid of potentiation of central nervous system depressant effects of ethanol or barbiturates. 
  • 3-[211At]astato-4-fluorobenzylguanidine: a potential therapeutic agent with prolonged retention by neuroblastoma cells. 
  • 3D cardiac μtissues within a microfluidic device with real-time contractile stress readout. 
  • 3D fiber tractography with susceptibility tensor imaging. 
  • 3D model of frequency representation in the cochlear nucleus of the CBA/J mouse. 
  • 3He MRI in mouse models of asthma. 
  • 4-D micro-CT of the mouse heart. 
  • 4.5 kb of the rat tyrosine hydroxylase 5' flanking sequence directs tissue specific expression during development and contains consensus sites for multiple transcription factors. 
  • 440-kD ankyrinB: structure of the major developmentally regulated domain and selective localization in unmyelinated axons. 
  • 4D MRI of polycystic kidneys from rapamycin-treated Glis3-deficient mice. 
  • 4D micro-CT for cardiac and perfusion applications with view under sampling. 
  • 4D micro-CT using fast prospective gating. 
  • 5' UTR m(6)A Promotes Cap-Independent Translation. 
  • 5' flanking sequences of the rat tyrosine hydroxylase gene target accurate tissue-specific, developmental, and transsynaptic expression in transgenic mice. 
  • 5,6-EET is released upon neuronal activity and induces mechanical pain hypersensitivity via TRPA1 on central afferent terminals. 
  • 5-HT2C Agonists Modulate Schizophrenia-Like Behaviors in Mice. 
  • 5-Hydroxymethylcytosine (5hmC) and Ten-eleven translocation 1-3 (TET1-3) proteins in the dorsal root ganglia of mouse: Expression and dynamic regulation in neuropathic pain. 
  • 5-Iodo-A-85380, an alpha4beta2 subtype-selective ligand for nicotinic acetylcholine receptors. 
  • 5α-Reductase inhibition coupled with short off cycles increases survival in the LNCaP xenograft prostate tumor model on intermittent androgen deprivation therapy. 
  • 64Cu-p-NH2-Bn-DOTA-hu14.18K322A, a PET radiotracer targeting neuroblastoma and melanoma. 
  • 7, 8-Dihydroxyflavone induces synapse expression of AMPA GluA1 and ameliorates cognitive and spine abnormalities in a mouse model of fragile X syndrome. 
  • A 10-gene progenitor cell signature predicts poor prognosis in lung adenocarcinoma. 
  • A 30-kDa alternative translation product of the CCAAT/enhancer binding protein alpha message: transcriptional activator lacking antimitotic activity. 
  • A 4-methyl-substituted meta-iodobenzylguanidine analogue with prolonged retention in human neuroblastoma cells. 
  • A 40-kilodalton protein binds specifically to an upstream sequence element essential for muscle-specific transcription of the human myoglobin promoter. 
  • A 57,000-mol-wt protein uniquely present in nonproliferating cells and senescent human fibroblasts. 
  • A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. 
  • A Bayesian approach for joint modeling of cluster size and subunit-specific outcomes. 
  • A CALM-derived nuclear export signal is essential for CALM-AF10-mediated leukemogenesis. 
  • A CD19-dependent signaling pathway regulates autoimmunity in Lyn-deficient mice. 
  • A CNS catecholaminergic cell line expresses voltage-gated currents. 
  • A CRISPR-Cas system enhances envelope integrity mediating antibiotic resistance and inflammasome evasion. 
  • A CRISPR/Cas9-based system for reprogramming cell lineage specification. 
  • A CaMK cascade activates CRE-mediated transcription in neurons of Caenorhabditis elegans. 
  • A Commencement for Eye Commensals. 
  • A Cre-inducible fluorescent reporter for observing apical membrane dynamics. 
  • A DLL3-targeted antibody-drug conjugate eradicates high-grade pulmonary neuroendocrine tumor-initiating cells in vivo. 
  • A Diffusion MRI Tractography Connectome of the Mouse Brain and Comparison with Neuronal Tracer Data. 
  • A Fas-associated death domain protein/caspase-8-signaling axis promotes S-phase entry and maintains S6 kinase activity in T cells responding to IL-2. 
  • A Fluorescence-Guided Laser Ablation System for Removal of Residual Cancer in a Mouse Model of Soft Tissue Sarcoma. 
  • A Fluorescent Hsp90 Probe Demonstrates the Unique Association between Extracellular Hsp90 and Malignancy in Vivo. 
  • A Fluorometric Method of Measuring Carboxypeptidase Activities for Angiotensin II and Apelin-13. 
  • A GABAergic nigrotectal pathway for coordination of drinking behavior. 
  • A Genetic Porcine Model of Cancer. 
  • A Gαs DREADD mouse for selective modulation of cAMP production in striatopallidal neurons. 
  • A MAP kinase cascade composed of cell type specific and non-specific elements controls mating and differentiation of the fungal pathogen Cryptococcus neoformans. 
  • A Method to Target and Isolate Airway-innervating Sensory Neurons in Mice. 
  • A Molecular Profile of the Endothelial Cell Response to Ionizing Radiation. 
  • A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes. 
  • A Mouse Model of Orthopedic Surgery to Study Postoperative Cognitive Dysfunction and Tissue Regeneration. 
  • A Non-Canonical Role for β-Secretase in the Retina. 
  • A Notch positive feedback in the intestinal stem cell niche is essential for stem cell self-renewal. 
  • A Novel Carcinoembryonic Antigen T-Cell Bispecific Antibody (CEA TCB) for the Treatment of Solid Tumors. 
  • A Novel Mouse Model of Diffuse Intrinsic Pontine Glioma Initiated in Pax3-Expressing Cells. 
  • A Novel Murine Model of Marfan Syndrome Accelerates Aortopathy and Cardiomyopathy. 
  • A Novel Phosphoregulatory Switch Controls the Activity and Function of the Major Catalytic Subunit of Protein Kinase A in Aspergillus fumigatus. 
  • A PGC-1α isoform induced by resistance training regulates skeletal muscle hypertrophy. 
  • A PK2/Bv8/PROK2 antagonist suppresses tumorigenic processes by inhibiting angiogenesis in glioma and blocking myeloid cell infiltration in pancreatic cancer. 
  • A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus. 
  • A Period2 Phosphoswitch Regulates and Temperature Compensates Circadian Period. 
  • A Plasmonic Gold Nanostar Theranostic Probe for In Vivo Tumor Imaging and Photothermal Therapy. 
  • A Potential Contributory Role for Ciliary Dysfunction in the 16p11.2 600 kb BP4-BP5 Pathology. 
  • A Progenitor Cell Expressing Transcription Factor RORγt Generates All Human Innate Lymphoid Cell Subsets. 
  • A Protocol for the Comprehensive Flow Cytometric Analysis of Immune Cells in Normal and Inflamed Murine Non-Lymphoid Tissues. 
  • A Protocol for the Production of Integrase-deficient Lentiviral Vectors for CRISPR/Cas9-mediated Gene Knockout in Dividing Cells. 
  • A RIPK3-caspase 8 complex mediates atypical pro-IL-1β processing. 
  • A Ras1-Cdc24 signal transduction pathway mediates thermotolerance in the fungal pathogen Cryptococcus neoformans. 
  • A SMAP in the face for cancer. 
  • A Sch9 protein kinase homologue controlling virulence independently of the cAMP pathway in Cryptococcus neoformans. 
  • A T cell intrinsic role of Id3 in a mouse model for primary Sjogren's syndrome. 
  • A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion. 
  • A Three-Dimensional Organoid Culture System Derived from Human Glioblastomas Recapitulates the Hypoxic Gradients and Cancer Stem Cell Heterogeneity of Tumors Found In Vivo. 
  • A Transcriptional Signature Identifies LKB1 Functional Status as a Novel Determinant of MEK Sensitivity in Lung Adenocarcinoma. 
  • A WAVE-1 and WRP signaling complex regulates spine density, synaptic plasticity, and memory. 
  • A WW domain-containing yes-associated protein (YAP) is a novel transcriptional co-activator. 
  • A Western diet induced NAFLD in LDLR(-/)(-) mice is associated with reduced hepatic glutathione synthesis. 
  • A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels. 
  • A barrier-type insulator forms a boundary between active and inactive chromatin at the murine TCRβ locus. 
  • A beta-arrestin 2 signaling complex mediates lithium action on behavior. 
  • A beta-arrestin-biased agonist of the parathyroid hormone receptor (PTH1R) promotes bone formation independent of G protein activation. 
  • A bidirectional phage display vector for the selection and mass transfer of polyclonal antibody libraries. 
  • A bioactive titanium foam scaffold for bone repair. 
  • A bipartite interaction between Hsp70 and CHIP regulates ubiquitination of chaperoned client proteins. 
  • A blood spot method for detecting fumonisin-induced changes in putative sphingolipid biomarkers in LM/Bc mice and humans. 
  • A brief history of tissue models for cardiac electrophysiology. 
  • A c-Fos- and E1A-interacting component of the tissue factor basal promoter complex mediates synergistic activation of transcription by transforming growth factor-beta1. 
  • A c-Myc and surface CD19 signaling amplification loop promotes B cell lymphoma development and progression in mice. 
  • A calcineurin-dependent transcriptional pathway controls skeletal muscle fiber type. 
  • A candidate gene for congenital bilateral isolated ptosis identified by molecular analysis of a de novo balanced translocation. 
  • A candidate taste receptor gene near a sweet taste locus. 
  • A cardiac arrhythmia syndrome caused by loss of ankyrin-B function. 
  • A catalytic antioxidant (AEOL 10150) attenuates expression of inflammatory genes in stroke. 
  • A cell-intrinsic role for CaMKK2 in granulocyte lineage commitment and differentiation. 
  • A cell-intrinsic role for Mst1 in regulating thymocyte egress. 
  • A cell-specific nuclear receptor is essential for adrenal and gonadal development and sexual differentiation. 
  • A cell-specific nuclear receptor plays essential roles in adrenal and gonadal development. 
  • A cell-specific nuclear receptor regulates the steroid hydroxylases. 
  • A central role for S-nitrosylation in apoptosis. 
  • A centrosomal mechanism involving CDK5RAP2 and CENPJ controls brain size. 
  • A ceramide-centric view of insulin resistance. 
  • A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice. 
  • A chemical glycoproteomics platform reveals O-GlcNAcylation of mitochondrial voltage-dependent anion channel 2. 
  • A chemokine expressed in lymphoid high endothelial venules promotes the adhesion and chemotaxis of naive T lymphocytes. 
  • A circuit for motor cortical modulation of auditory cortical activity. 
  • A circuit model for saccadic suppression in the superior colliculus. 
  • A cluster of virus-encoded microRNAs accelerates acute systemic Epstein-Barr virus infection but does not significantly enhance virus-induced oncogenesis in vivo. 
  • A combination of 5-fluorouracil and membrane-bound antibody inhibits B-cell lymphoma growth in a mouse model system. 
  • A combination of independent transcriptional regulators shapes bacterial virulence gene expression during infection. 
  • A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. 
  • A common variant mapping to CACNA1A is associated with susceptibility to exfoliation syndrome. 
  • A comparative analysis of EGFR-targeting antibodies for gold nanoparticle CT imaging of lung cancer. 
  • A comparative study of the distributions of renin and angiotensinogen messenger ribonucleic acids in rat and mouse tissues. 
  • A comparison of antiangiogenic therapies for the prevention of liver metastases. 
  • A comparison of least squares and conditional maximum likelihood estimators under volume endpoint censoring in tumor growth experiments. 
  • A comparison of murine T-cell-depleted adult bone marrow and full-term fetal blood cells in hematopoietic engraftment and immune reconstitution. 
  • A comparison of neuroinflammation to implanted microelectrodes in rat and mouse models. 
  • A comparison of non-toxin vaccine adjuvants for their ability to enhance the immunogenicity of nasally-administered anthrax recombinant protective antigen. 
  • A comparison of oral and rectal absorption of L-dopa esters in rats and mice. 
  • A comparison of radial keyhole strategies for high spatial and temporal resolution 4D contrast-enhanced MRI in small animal tumor models. 
  • A comparison of strain-related susceptibility in two murine recovery models of global cerebral ischemia. 
  • A comparison of the genes coding for canonical TRP channels and their M, V and P relatives. 
  • A component of the mir-17-92 polycistronic oncomir promotes oncogene-dependent apoptosis. 
  • A comprehensive method for optical-emission computed tomography. 
  • A comprehensive search for calcium binding sites critical for TMEM16A calcium-activated chloride channel activity. 
  • A computer model of engineered cardiac monolayers. 
  • A computer program for displaying two-dimensional gel electrophoresis data. 
  • A conserved Pbx-Wnt-p63-Irf6 regulatory module controls face morphogenesis by promoting epithelial apoptosis. 
  • A conserved docking motif for CK1 binding controls the nuclear localization of NFAT1. 
  • A conserved transcriptional enhancer regulates RAG gene expression in developing B cells. 
  • A cord blood monocyte-derived cell therapy product accelerates brain remyelination. 
  • A cortical filter that learns to suppress the acoustic consequences of movement. 
  • A craniofacial-specific monosynaptic circuit enables heightened affective pain. 
  • A critical precursor frequency of donor-reactive CD4+ T cell help is required for CD8+ T cell-mediated CD28/CD154-independent rejection. 
  • A critical regulatory role for macrophage migration inhibitory factor in hyperoxia-induced injury in the developing murine lung. 
  • A critical role for CRM1 in regulating HOXA gene transcription in CALM-AF10 leukemias. 
  • A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism. 
  • A critical role for chloride channel-3 (CIC-3) in smooth muscle cell activation and neointima formation. 
  • A critical role for direct TLR2-MyD88 signaling in CD8 T-cell clonal expansion and memory formation following vaccinia viral infection. 
  • A critical role for the autophagy gene Atg5 in T cell survival and proliferation. 
  • A critical role for type I IFN-dependent NK cell activation in innate immune elimination of adenoviral vectors in vivo. 
  • A critical role of eEF-2K in mediating autophagy in response to multiple cellular stresses. 
  • A crucial role of L-selectin in C protein-induced experimental polymyositis in mice. 
  • A cut above the other caspases. 
  • A cyclin D1/microRNA 17/20 regulatory feedback loop in control of breast cancer cell proliferation. 
  • A cytogenetic comparison of the responses of mouse and human peripheral blood lymphocytes to 60Co gamma radiation. 
  • A cytokine cocktail directly modulates the phenotype of DC-enriched anti-tumor T cells to convey potent anti-tumor activities in a murine model. 
  • A de novo deafwaddler mutation of Pmca2 arising in ES cells and hitchhiking with a targeted modification of the Pparg gene. 
  • A defect in the humoral immune response to protein antigens and haptens in immunoglobulin mu heavy-chain transgenic mice. 
  • A deficit in astroglial organization causes the impaired reactive sprouting in human apolipoprotein E4 targeted replacement mice. 
  • A depot-forming glucagon-like peptide-1 fusion protein reduces blood glucose for five days with a single injection. 
  • A designed glycoprotein analogue of Gc-MAF exhibits native-like phagocytic activity. 
  • A developmental switch from TCR delta enhancer to TCR alpha enhancer function during thymocyte maturation. 
  • A device to study the effects of stretch gradients on cell behavior. 
  • A differential role for endocytosis in receptor-mediated activation of Nox1. 
  • A direct HDAC4-MAP kinase crosstalk activates muscle atrophy program. 
  • A direct link between carbohydrate utilization and virulence in the major human pathogen group A Streptococcus. 
  • A direct regulatory interaction between chaperonin TRiC and stress-responsive transcription factor HSF1. 
  • A discrete chromatin loop in the mouse Tcra-Tcrd locus shapes the TCRδ and TCRα repertoires. 
  • A diverse population of Cryptococcus gattii molecular type VGIII in southern Californian HIV/AIDS patients. 
  • A dopamine D1 receptor-dependent β-arrestin signaling complex potentially regulates morphine-induced psychomotor activation but not reward in mice. 
  • A double hit to kill tumor and endothelial cells by TRAIL and antiangiogenic 3TSR. 
  • A dual role for NOTCH signaling in joint cartilage maintenance and osteoarthritis. 
  • A dual-emissive-materials design concept enables tumour hypoxia imaging. 
  • A dynamic dual role of IL-2 signaling in the two-step differentiation process of adaptive regulatory T cells. 
  • A family of candidate taste receptors in human and mouse. 
  • A family of hierarchically self-assembling linear-dendritic hybrid polymers for highly efficient targeted gene delivery. 
  • A feasibility study using radiochromic films for fast neutron 2D passive dosimetry. 
  • A first-generation X-inactivation profile of the human X chromosome. 
  • A fixative for use in muscle histochemistry. 
  • A flucytosine-responsive Mbp1/Swi4-like protein, Mbs1, plays pleiotropic roles in antifungal drug resistance, stress response, and virulence of Cryptococcus neoformans. 
  • A fluorescent assay for agonist-activated phospholipase D in mammalian cell extracts. 
  • A functional analysis of the spacer of V(D)J recombination signal sequences. 
  • A functional mouse ornithine decarboxylase gene (Odc) maps to chromosome 12: further evidence of homoeology between mouse chromosome 12 and the short arm of human chromosome 2. 
  • A functional role for circulating mouse L-selectin in regulating leukocyte/endothelial cell interactions in vivo. 
  • A functional variant in HOXA11-AS, a novel long non-coding RNA, inhibits the oncogenic phenotype of epithelial ovarian cancer. 
  • A futile metabolic cycle activated in adipocytes by antidiabetic agents. 
  • A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. 
  • A gene atlas of the mouse and human protein-encoding transcriptomes. 
  • A gene mapping to the sex-determining region of the mouse Y chromosome is a member of a novel family of embryonically expressed genes. 
  • A general approach for two-stage analysis of multilevel clustered non-Gaussian data. 
  • A genetic approach for studying the physiology of the type 1A (AT1A) angiotensin receptor. 
  • A genetically defined normal human somatic cell system to study ras oncogenesis in vivo and in vitro. 
  • A genetically engineered thermally responsive sustained release curcumin depot to treat neuroinflammation. 
  • A genetically modified allogeneic cellular vaccine generates MHC class I-restricted cytotoxic responses against tumor-associated antigens and protects against CNS tumors in vivo. 
  • A genetically tractable model of human glioma formation. 
  • A genome end-game: understanding gene function in the nervous system. 
  • A genome-wide Drosophila screen for heat nociception identifies α2δ3 as an evolutionarily conserved pain gene. 
  • A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25. 
  • A genomic regulatory element that directs assembly and function of immune-specific AP-1-IRF complexes. 
  • A glycoengineered anti-CD19 antibody with potent antibody-dependent cellular cytotoxicity activity in vitro and lymphoma growth inhibition in vivo. 
  • A grafted ovarian fragment rescues host fertility after chemotherapy. 
  • A greater role for the norepinephrine transporter than the serotonin transporter in murine nociception. 
  • A guide to analysis of mouse energy metabolism. 
  • A gut-brain neural circuit for nutrient sensory transduction. 
  • A hag mutant of Moraxella catarrhalis strain O35E is deficient in hemagglutination, autoagglutination, and immunoglobulin D-binding activities. 
  • A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration. 
  • A herpes simplex virus 1 integration site in the mouse genome defined by somatic cell genetic analysis. 
  • A hierarchy of ankyrin-spectrin complexes clusters sodium channels at nodes of Ranvier. 
  • A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity. 
  • A high expression level of insulin-like growth factor I receptor is associated with increased expression of transcription factor Sp1 and regional lymph node metastasis of human gastric cancer. 
  • A high throughput screen identifies Nefopam as targeting cell proliferation in β-catenin driven neoplastic and reactive fibroproliferative disorders. 
  • A high-density integrated genetic linkage and radiation hybrid map of the laboratory rat. 
  • A high-performance liquid chromatography method for the quantification of cysmethynil, an inhibitor of isoprenylcysteine carboxylmethyl transferase, in mouse plasma. 
  • A high-precision contrast injector for small animal x-ray digital subtraction angiography. 
  • A high-resolution anatomical ontology of the developing murine genitourinary tract. 
  • A high-temperature superconducting Helmholtz probe for microscopy at 9.4 T. 
  • A high-throughput in vitro drug screen in a genetically engineered mouse model of diffuse intrinsic pontine glioma identifies BMS-754807 as a promising therapeutic agent. 
  • A highly efficient strategy to determine genotypes of genetically-engineered mice using genomic DNA purified from hair roots. 
  • A highly selective Hsp90 affinity chromatography resin with a cleavable linker. 
  • A highly selective inhibitor of I kappa B kinase, BMS-345541, blocks both joint inflammation and destruction in collagen-induced arthritis in mice. 
  • A highly selective inhibitor of IkappaB kinase, BMS-345541, augments graft survival mediated by suboptimal immunosuppression in a murine model of cardiac graft rejection. 
  • A human CD46 transgenic pig model system for the study of discordant xenotransplantation. 
  • A human erythropoietin receptor gene mutant causing familial erythrocytosis is associated with deregulation of the rates of Jak2 and Stat5 inactivation. 
  • A human immunoglobulin gene reduces the incidence of lymphomas in c-Myc-bearing transgenic mice. 
  • A human monoclonal antibody prevents malaria infection by targeting a new site of vulnerability on the parasite. 
  • A hypothetic mechanism of diethylstilbestrol(DES)-induced anomalies in exposed progeny. 
  • A large-scale method for the selective depletion of alphabeta T lymphocytes from PBSC for allogeneic transplantation. 
  • A lentiviral RNAi library for human and mouse genes applied to an arrayed viral high-content screen. 
  • A linkage map of mouse chromosome 8: further definition of homologous linkage relationships between mouse chromosome 8 and human chromosomes 8, 16, and 19. 
  • A liposomal nanoscale contrast agent for preclinical CT in mice. 
  • A local hyperthermia treatment which enhances antibody uptake in a glioma xenograft model does not affect tumour interstitial fluid pressure. 
  • A locus mapping to mouse chromosome 7 determines infarct volume in a mouse model of ischemic stroke. 
  • A lymphotoxin-IFN-beta axis essential for lymphocyte survival revealed during cytomegalovirus infection. 
  • A macrophage subpopulation recruited by CC chemokine ligand-2 clears apoptotic cells in noninfectious lung injury. 
  • A major role for the EP4 receptor in regulation of renin. 
  • A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. 
  • A manganese porphyrin superoxide dismutase mimetic enhances tumor radioresponsiveness. 
  • A mastoparan-derived peptide has broad-spectrum antiviral activity against enveloped viruses. 
  • A mathematical model of tryptophan metabolism via the kynurenine pathway provides insights into the effects of vitamin B-6 deficiency, tryptophan loading, and induction of tryptophan 2,3-dioxygenase on tryptophan metabolites. 
  • A matrix for new ideas in pulmonary fibrosis. 
  • A mechanism for gene-environment interaction in the etiology of congenital scoliosis. 
  • A mechanism-based antioxidant approach for the reduction of skin carcinogenesis. 
  • A mechanism-based complementary screening approach for the amelioration and reversal of neurobehavioral teratogenicity. 
  • A member of a family of sulfate-activating enzymes causes murine brachymorphism. 
  • A membrane-associated progesterone-binding protein, 25-Dx, is regulated by progesterone in brain regions involved in female reproductive behaviors. 
  • A metabolic enzyme for S-nitrosothiol conserved from bacteria to humans. 
  • A metabolomic study of the PPARδ agonist GW501516 for enhancing running endurance in Kunming mice. 
  • A metalloporphyrin antioxidant alters cytokine responses after irradiation in a prostate tumor model. 
  • A metalloporphyrin-based superoxide dismutase mimic inhibits adoptive transfer of autoimmune diabetes by a diabetogenic T-cell clone. 
  • A method for determination of antibody-dependent cellular cytotoxicity (ADCC) of human peripheral mononuclear cells. 
  • A method for linking VL and VH region genes that allows bulk transfer between vectors for use in generating polyclonal IgG libraries. 
  • A method for the radiohalogenation of proteins resulting in decreased thyroid uptake of radioiodine. 
  • A methodology for utilization of predictive genomic signatures in FFPE samples. 
  • A methylthioadenosine phosphorylase (MTAP) fusion transcript identifies a new gene on chromosome 9p21 that is frequently deleted in cancer. 
  • A miR-34a-Numb Feedforward Loop Triggered by Inflammation Regulates Asymmetric Stem Cell Division in Intestine and Colon Cancer. 
  • A micro-CT analysis of murine lung recruitment in bleomycin-induced lung injury. 
  • A micro-computed tomography-based method for the measurement of pulmonary compliance in healthy and bleomycin-exposed mice. 
  • A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation. 
  • A microarray analysis of the XX Wnt4 mutant gonad targeted at the identification of genes involved in testis vascular differentiation. 
  • A microfluidic system for investigation of extravascular transport and cellular uptake of drugs in tumors. 
  • A mitotic recombination system for mouse chromosome 17. 
  • A model for human medulloblastoma. Growth, morphology, and chromosomal analysis in vitro and in athymic mice. 
  • A model for optimizing adenoviral delivery in human cancer gene therapy trials. 
  • A model of muscle atrophy using cast immobilization in mice. 
  • A modern Cosmas and Damian: Sir Roy Calne and Thomas Starzl receive the 2012 Lasker~Debakey Clinical Medical Research Award. 
  • A molecular genetic linkage map of mouse chromosome 7. 
  • A monoclonal antibody IMab-1 specifically recognizes IDH1R132H, the most common glioma-derived mutation. 
  • A monoclonal antibody reactive with a second epitope of the 67,000-dalton human T cell antigen. 
  • A monoclonal antibody specific for the amino terminal sequence of human prorenin identifies a common epitope on renal and amniotic fluid inactive renins. 
  • A monoclonal antibody that targets a NaV1.7 channel voltage sensor for pain and itch relief. 
  • A morphological analysis endocrine tumour genesis in pancreas and anterior pituitary of AVP/SV40 transgenic mice. 
  • A mouse bleeding model to study oral anticoagulants. 
  • A mouse homoeo box gene is expressed during embryogenesis and in adult kidney. 
  • A mouse homologue of FAST-1 transduces TGF beta superfamily signals and is expressed during early embryogenesis. 
  • A mouse macrophage lipidome. 
  • A mouse model for heparin-induced thrombocytopenia. 
  • A mouse model for hereditary hemorrhagic telangiectasia (HHT) type 2. 
  • A mouse model of adult-onset anaemia due to erythropoietin deficiency. 
  • A mouse model of congenital heart disease: cardiac arrhythmias and atrial septal defect caused by haploinsufficiency of the cardiac transcription factor Csx/Nkx2.5. 
  • A mouse model of familial porphyria cutanea tarda. 
  • A mouse model of higher visual cortical function. 
  • A mouse model of juvenile hemochromatosis. 
  • A mouse-human phase 1 co-clinical trial of a protease-activated fluorescent probe for imaging cancer. 
  • A multigene family encoding a diverse array of putative pheromone receptors in mammals. 
  • A multimodal micro-optrode combining field and single unit recording, multispectral detection and photolabeling capabilities. 
  • A murine Ig light chain transgene reveals IGKV3 gene contributions to anti-collagen types IV and II specificities. 
  • A murine model for short-chain acyl-CoA dehydrogenase deficiency. 
  • A murine model of hyperdopaminergic state displays altered respiratory control. 
  • A murine monoclonal antibody directed against the carboxyl-terminal domain of GRP78 suppresses melanoma growth in mice. 
  • A mutant PTH/PTHrP type I receptor in enchondromatosis. 
  • A mutant form of p135tyk2, an interferon-alpha inducible tyrosine kinase, suppresses the transformed phenotype of Daudi cells. 
  • A mutation in SLC24A1 implicated in autosomal-recessive congenital stationary night blindness. 
  • A mutation in Sec15l1 causes anemia in hemoglobin deficit (hbd) mice. 
  • A mutation in a mitochondrial transmembrane protein is responsible for the pleiotropic hematological and skeletal phenotype of flexed-tail (f/f) mice. 
  • A mutation in the glycine binding pocket of the N-methyl-D-aspartate receptor NR1 subunit alters agonist efficacy. 
  • A natural structural variant of the mouse TCR beta-chain displays intrinsic receptor function and antigen specificity. 
  • A network of genetic events sufficient to convert normal human cells to a tumorigenic state. 
  • A network of substrates of the E3 ubiquitin ligases MDM2 and HUWE1 control apoptosis independently of p53. 
  • A neural network-based method for spectral distortion correction in photon counting x-ray CT. 
  • A neuron-specific host microRNA targets herpes simplex virus-1 ICP0 expression and promotes latency. 
  • A neuronal model of Alzheimer's disease: an insight into the mechanisms of oxidative stress-mediated mitochondrial injury. 
  • A neutralizing epitope of the superantigen SEA has agonist activity on T cells. 
  • A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme. 
  • A new EV71 VP3 epitope in norovirus P particle vector displays neutralizing activity and protection in vivo in mice. 
  • A new SOD mimic, Mn(III) ortho N-butoxyethylpyridylporphyrin, combines superb potency and lipophilicity with low toxicity. 
  • A new activating role for CO in cardiac mitochondrial biogenesis. 
  • A new approach to the study of immunity to schistosomes. 
  • A new kinetic framework for synaptic vesicle trafficking tested in synapsin knock-outs. 
  • A new method for the cytological analysis of autoantibody specificities using whole-mount, surface-spread meiotic nuclei. 
  • A new millenium for spinal cord regeneration: growth-associated genes. 
  • A new one-step method for the functional assay of the fourth component (C4) of human and guinea pig complement. 
  • A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance of superoxide dismutase, lactoferrin, and alpha 2-macroglobulin. 
  • A new role for ATM: regulating mitochondrial function and mitophagy. 
  • A new strategy for studying protein kinase B and its three isoforms. Role of protein kinase B in phosphorylating glycogen synthase kinase-3, tuberin, WNK1, and ATP citrate lyase. 
  • A new temperature-sensitive liposome for use with mild hyperthermia: characterization and testing in a human tumor xenograft model. 
  • A next-generation dual-recombinase system for time- and host-specific targeting of pancreatic cancer. 
  • A no-laminectomy spinal cord compression injury model in mice. 
  • A non-oncogenic HPV 16 E6/E7 vaccine enhances treatment of HPV expressing tumors. 
  • A nonantigenic covalent streptokinase-polyethylene glycol complex with plasminogen activator function. 
  • A nonpolio enterovirus with respiratory tropism causes poliomyelitis in intercellular adhesion molecule 1 transgenic mice. 
  • A nonsteroid anti-inflammatory drug exacerbates Coxsackie B3 murine myocarditis. 
  • A novel Bcr-Abl-mTOR-eIF4A axis regulates IRES-mediated translation of LEF-1. 
  • A novel C-terminal binding protein (CTBP2) is closely related to CTBP1, an adenovirus E1A-binding protein, and maps to human chromosome 21q21.3. 
  • A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism. 
  • A novel EGFR isoform confers increased invasiveness to cancer cells. 
  • A novel SV40 TAg transgenic model of asbestos-induced mesothelioma: malignant transformation is dose dependent. 
  • A novel angiopoietin-derived peptide displays anti-angiogenic activity and inhibits tumour-induced and retinal neovascularization. 
  • A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity. 
  • A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage. 
  • A novel approach to maintain gut mucosal integrity using an oral enzyme supplement. 
  • A novel basal promoter element is required for expression of the rat tyrosine hydroxylase gene. 
  • A novel catecholamine-activated adenosine cyclic 3',5'-phosphate independent pathway for beta-adrenergic receptor phosphorylation in wild-type and mutant S49 lymphoma cells: mechanism of homologous desensitization of adenylate cyclase. 
  • A novel conditionally replicating "armed" adenovirus selectively targeting gastrointestinal tumors with aberrant wnt signaling. 
  • A novel flow-perfusion bioreactor supports 3D dynamic cell culture. 
  • A novel genetic locus modulates infarct volume independently of the extent of collateral circulation. 
  • A novel immune competent murine hypertrophic scar contracture model: a tool to elucidate disease mechanism and develop new therapies. 
  • A novel immunocompetent murine tumor model for the evaluation of RCAd-enhanced RDAd transduction efficacy. 
  • A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells. 
  • A novel mechanism for Bcr-Abl action: Bcr-Abl-mediated induction of the eIF4F translation initiation complex and mRNA translation. 
  • A novel mechanism for regulating transforming growth factor beta (TGF-beta) signaling. Functional modulation of type III TGF-beta receptor expression through interaction with the PDZ domain protein, GIPC. 
  • A novel method for viral gene delivery in solid tumors. 
  • A novel model for IFN-γ-mediated autoinflammatory syndromes. 
  • A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis. 
  • A novel modifier gene for plasma von Willebrand factor level maps to distal mouse chromosome 11. 
  • A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. 
  • A novel mouse model of depletion of stellate cells clarifies their role in ischemia/reperfusion- and endotoxin-induced acute liver injury. 
  • A novel mouse model of podocyte depletion. 
  • A novel murine model of inflammatory bowel disease and inflammation-associated colon cancer with ulcerative colitis-like features. 
  • A novel murine oncornavirus with dual eco- and xenotropic properties. 
  • A novel murine protein with no effect on iron homoeostasis is homologous with transferrin and is the putative inhibitor of carbonic anhydrase. 
  • A novel mutation in the erythropoietin receptor gene is associated with familial erythrocytosis. 
  • A novel neoplastic primary tumor-derived human prostate epithelial cell line. 
  • A novel neurotoxoid vaccine prevents mucosal botulism. 
  • A novel receptor function for the heat shock protein Grp78: silencing of Grp78 gene expression attenuates alpha2M*-induced signalling. 
  • A novel redox regulator, MnTnBuOE-2-PyP5+, enhances normal hematopoietic stem/progenitor cell function. 
  • A novel rodent mammary window of orthotopic breast cancer for intravital microscopy. 
  • A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis. 
  • A novel role for activation-induced cytidine deaminase: central B-cell tolerance. 
  • A novel role for copper in Ras/mitogen-activated protein kinase signaling. 
  • A novel role for type 1 angiotensin receptors on T lymphocytes to limit target organ damage in hypertension. 
  • A novel role of the WNT-dishevelled-GSK3β signaling cascade in the mouse nucleus accumbens in a social defeat model of depression. 
  • A novel species-specific RNA related to alternatively spliced amyloid precursor protein mRNAs. 
  • A novel therapeutic derived from apolipoprotein E reduces brain inflammation and improves outcome after closed head injury. 
  • A novel toll-like receptor 9 agonist cooperates with trastuzumab in trastuzumab-resistant breast tumors through multiple mechanisms of action. 
  • A novel, clinically relevant animal model of metastatic pancreatic adenocarcinoma biology and therapy. 
  • A novel, topologically constrained DNA molecule containing a double Holliday junction: design, synthesis, and initial biochemical characterization. 
  • A one-step large-scale method for T- and B-cell depletion of mobilized PBSC for allogeneic transplantation. 
  • A p-[18F]fluoroethoxyphenyl bicyclic nucleoside analogue as a potential positron emission tomography imaging agent for varicella-zoster virus thymidine kinase gene expression. 
  • A pH-gated conformational switch regulates the phosphatase activity of bifunctional HisKA-family histidine kinases. 
  • A paclitaxel-loaded recombinant polypeptide nanoparticle outperforms Abraxane in multiple murine cancer models. 
  • A pathogenetic role for TNF alpha in the syndrome of cachexia, arthritis, and autoimmunity resulting from tristetraprolin (TTP) deficiency. 
  • A peptide inhibitor derived from p55PIK phosphatidylinositol 3-kinase regulatory subunit: a novel cancer therapy. 
  • A pharmacoproteomic approach implicates eukaryotic elongation factor 2 kinase in ER stress-induced cell death. 
  • A phase I trial of hyperthermia-induced interleukin-12 gene therapy in spontaneously arising feline soft tissue sarcomas. 
  • A phase I-II study evaluating the murine anti-IL-2 receptor antibody 2A3 for treatment of acute graft-versus-host disease. 
  • A physical map of the mouse genome. 
  • A piggyBac insertion disrupts Foxl2 expression that mimics BPES syndrome in mice. 
  • A pilot study: 131I-antitenascin monoclonal antibody 81c6 to deliver a 44-Gy resection cavity boost. 
  • A point mutation (D79N) of the alpha2A adrenergic receptor abolishes the antiepileptogenic action of endogenous norepinephrine. 
  • A possible mechanism for exonuclease 1-independent eukaryotic mismatch repair. 
  • A precisely regulated gene expression cassette potently modulates metastasis and survival in multiple solid cancers. 
  • A predicted secondary structural domain within the internal ribosome entry site of echovirus 12 mediates a cell-type-specific block to viral replication. 
  • A preliminary gene map for the Van der Woude syndrome critical region derived from 900 kb of genomic sequence at 1q32-q41. 
  • A preliminary investigation of the parallelogram concept in genetic monitoring and risk estimation. 
  • A prior feature SVM-MRF based method for mouse brain segmentation. 
  • A probabilistic approach to demixing odors. 
  • A procedure for the preferential radioiodination of small amounts of protein in the presence of excess lipids. 
  • A promising approach for treatment of tumor-induced bone diseases: utilizing bisphosphonate derivatives of nucleoside antimetabolites. 
  • A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. 
  • A proteomics approach to the identification of mammalian mitochondrial small subunit ribosomal proteins. 
  • A protocol for heterologous expression and functional assay for mouse pheromone receptors. 
  • A protocol for imaging alternative splicing regulation in vivo using fluorescence reporters in transgenic mice. 
  • A proximal mouse chromosome 9 linkage map that further defines linkage groups homologous with segments of human chromosomes 11, 15, and 19. 
  • A quantitative microscopic approach to predict local recurrence based on in vivo intraoperative imaging of sarcoma tumor margins. 
  • A quantitative trait locus (LSq-1) on mouse chromosome 7 is linked to the absence of tissue loss after surgical hindlimb ischemia. 
  • A rapid cytoplasmic mechanism for PI3 kinase regulation by the nuclear thyroid hormone receptor, TRβ, and genetic evidence for its role in the maturation of mouse hippocampal synapses in vivo. 
  • A rapidly dividing human medulloblastoma cell line (D283 MED) expresses all three neurofilament subunits. 
  • A rationally designed monomeric peptide triagonist corrects obesity and diabetes in rodents. 
  • A region of the beta subunit of the interferon alpha receptor different from box 1 interacts with Jak1 and is sufficient to activate the Jak-Stat pathway and induce an antiviral state. 
  • A registration based approach for 4D cardiac micro-CT using combined prospective and retrospective gating. 
  • A regulatory B cell subset with a unique CD1dhiCD5+ phenotype controls T cell-dependent inflammatory responses. 
  • A replication-defective human adenovirus recombinant serves as a highly efficacious vaccine carrier. 
  • A requirement for NF-kappaB activation in Bcr-Abl-mediated transformation. 
  • A research for the relationship between human papillomavirus and human uterine cervical carcinoma. II. Molecular genetic and ultrastructural study on the transforming activity of recombinant retrovirus containing human papillomavirus type 16 subgenomic sequences. 
  • A reversible aptamer improves outcome and safety in murine models of stroke and hemorrhage. 
  • A revised airway epithelial hierarchy includes CFTR-expressing ionocytes. 
  • A robust microparticle platform for a STING-targeted adjuvant that enhances both humoral and cellular immunity during vaccination. 
  • A robust platform for the synthesis of new tetracycline antibiotics. 
  • A robust protocol for regional evaluation of methacholine challenge in mouse models of allergic asthma using hyperpolarized 3He MRI. 
  • A robust strategy for negative selection of Cre-loxP recombination-based excision of transgenes in induced pluripotent stem cells. 
  • A rodent model of spontaneous stereotypy: initial characterization of developmental, environmental, and neurobiological factors. 
  • A role for AQP5 in activation of TRPV4 by hypotonicity: concerted involvement of AQP5 and TRPV4 in regulation of cell volume recovery. 
  • A role for CD21/CD35 and CD19 in responses to acute septic peritonitis: a potential mechanism for mast cell activation. 
  • A role for E2F activities in determining the fate of Myc-induced lymphomagenesis. 
  • A role for MAPK in feedback inhibition of Tcrb recombination. 
  • A role for Mediator complex subunit MED13L in Rb/E2F-induced growth arrest. 
  • A role for P-glycoprotein in environmental toxicology. 
  • A role for Pin1 in mammalian germ cell development and spermatogenesis. 
  • A role for Sp and nuclear receptor transcription factors in a cardiac hypertrophic growth program. 
  • A role for TREK1 in generating the slow afterhyperpolarization in developing starburst amacrine cells. 
  • A role for Wnt signalling in self-renewal of haematopoietic stem cells. 
  • A role for a lithium-inhibited Golgi nucleotidase in skeletal development and sulfation. 
  • A role for angiotensin II type 1 receptors on bone marrow-derived cells in the pathogenesis of angiotensin II-dependent hypertension. 
  • A role for c-FLIP(L) in the regulation of apoptosis, autophagy, and necroptosis in T lymphocytes. 
  • A role for cFLIP in B cell proliferation and stress MAPK regulation. 
  • A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation. 
  • A role for fractalkine and its receptor (CX3CR1) in cardiac allograft rejection. 
  • A role for histone acetylation in the developmental regulation of VDJ recombination. 
  • A role for immunogenic DNA in the pathogenesis of systemic lupus erythematosus. 
  • A role for nuclear factor kappa B/rel transcription factors in the regulation of the recombinase activator genes. 
  • A role for peroxisome proliferator-activated receptor γ coactivator-1 in the control of mitochondrial dynamics during postnatal cardiac growth. 
  • A role for repressive histone methylation in cocaine-induced vulnerability to stress. 
  • A role for the copper transporter Ctr1 in the synergistic interaction between hyperthermia and cisplatin treatment. 
  • A role for the cytoplasmic tail of the beta chain of CD8 in thymic selection. 
  • A role for the orphan steroid receptor Nur77 in apoptosis accompanying antigen-induced negative selection. 
  • A role for the putative tumor suppressor Bin1 in muscle cell differentiation. 
  • A role for the thromboxane receptor in L-NAME hypertension. 
  • A role for transient receptor potential vanilloid 4 in tonicity-induced neurogenic inflammation. 
  • A role for tumor necrosis factor receptor-2 and receptor-interacting protein in programmed necrosis and antiviral responses. 
  • A role of matrix metalloproteinase-8 in atherosclerosis. 
  • A route to brightly fluorescent carbon nanotubes for near-infrared imaging in mice. 
  • A scanning electron microscope study of the extraembryonic endoderm of the 8th-day mouse embryo. 
  • A selective inhibitor of eIF2alpha dephosphorylation protects cells from ER stress. 
  • A self-adjuvanting supramolecular vaccine carrying a folded protein antigen. 
  • A self-assembling peptide acting as an immune adjuvant. 
  • A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. 
  • A sensitized mutagenesis screen identifies Gli3 as a modifier of Sox10 neurocristopathy. 
  • A sensory neuronal ion channel essential for airway inflammation and hyperreactivity in asthma. 
  • A serially transplantable human giant cell glioblastoma that maintains a near-haploid stem line. 
  • A shared vision. 
  • A signalling pathway controlling c-Myc degradation that impacts oncogenic transformation of human cells. 
  • A simple method to cure established tumors by inflammatory killing of normal cells. 
  • A simple, efficient tool for assessment of mice after unilateral cortex injury. 
  • A simplified synthesis of the hypoxia imaging agent 2-(2-Nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-[(18)F]pentafluoropropyl)-acetamide ([18F]EF5). 
  • A single amino acid change in the cytoplasmic domain of the simian immunodeficiency virus transmembrane molecule increases envelope glycoprotein expression on infected cells. 
  • A single genetic locus determines the efficacy of serum therapy against murine adenocarcinoma 755a. 
  • A single valine residue plays an essential role in peripherin/rds targeting to photoreceptor outer segments. 
  • A single-cycle vaccine vector based on vesicular stomatitis virus can induce immune responses comparable to those generated by a replication-competent vector. 
  • A small regulatory element from chromosome 19 enhances liver-specific gene expression. 
  • A small-molecule antagonist of the hedgehog signaling pathway. 
  • A small-molecule inhibitor of isoprenylcysteine carboxyl methyltransferase with antitumor activity in cancer cells. 
  • A spatially and temporally restricted mouse model of soft tissue sarcoma. 
  • A sphingosine kinase form 2 knockout sensitizes mouse myocardium to ischemia/reoxygenation injury and diminishes responsiveness to ischemic preconditioning. 
  • A spontaneous deletion within the desmoglein 3 extracellular domain of mice results in hypomorphic protein expression, immunodeficiency, and a wasting disease phenotype. 
  • A spontaneous, recurrent mutation in divalent metal transporter-1 exposes a calcium entry pathway. 
  • A standardized protocol for repeated social defeat stress in mice. 
  • A stimulus-specific role for CREB-binding protein (CBP) in T cell receptor-activated tumor necrosis factor alpha gene expression. 
  • A stress response pathway regulates DNA damage through β2-adrenoreceptors and β-arrestin-1. 
  • A study of dendritic and endothelial cell interactions in colon cancer in a cell line and small mammal model. 
  • A subgroup of murine monoclonal anti-deoxyribonucleic acid antibodies traverse the cytoplasm and enter the nucleus in a time-and temperature- dependent manner. 
  • A symmetrical Waxholm canonical mouse brain for NeuroMaps. 
  • A synaptic and circuit basis for corollary discharge in the auditory cortex. 
  • A synthetic matrix with independently tunable biochemistry and mechanical properties to study epithelial morphogenesis and EMT in a lung adenocarcinoma model. 
  • A synthetic random basic copolymer with promiscuous binding to class II major histocompatibility complex molecules inhibits T-cell proliferative responses to major and minor histocompatibility antigens in vitro and confers the capacity to prevent murine graft-versus-host disease in vivo. 
  • A systematic review of methodology applied during preclinical anesthetic neurotoxicity studies: important issues and lessons relevant to the design of future clinical research. 
  • A tamoxifen inducible knock-in allele for investigation of E2A function. 
  • A targeted and adjuvanted nanocarrier lowers the effective dose of liposomal amphotericin B and enhances adaptive immunity in murine cutaneous leishmaniasis. 
  • A technique for detection and relative quantitative analysis of glucosephosphate isomerase isozymes from nanogram tissue samples. 
  • A telomerase-immortalized primary human prostate cancer clonal cell line with neoplastic phenotypes. 
  • A tenascin knockout with a phenotype. 
  • A threshold for central T cell tolerance to an inducible serum protein. 
  • A timecourse analysis of systemic and gonadal effects of temperature on sexual development of the red-eared slider turtle Trachemys scripta elegans. 
  • A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis. 
  • A transcriptional repressor of osteopontin expression in the 4T1 murine breast cancer cell line. 
  • A transcriptional role for C/EBP beta in the neuronal response to axonal injury. 
  • A transgenic mouse prostate cancer model. 
  • A transgenic toolkit for visualizing and perturbing microtubules reveals unexpected functions in the epidermis. 
  • A transition zone complex regulates mammalian ciliogenesis and ciliary membrane composition. 
  • A translatable predictor of human radiation exposure. 
  • A translational bridge between mouse and human models of learned safety. 
  • A truncated isoform of c-Mpl with an essential C-terminal peptide targets the full-length receptor for degradation. 
  • A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS. 
  • A two-phase innate host response to alphavirus infection identified by mRNP-tagging in vivo. 
  • A tyrosine hydroxylase-yellow fluorescent protein knock-in reporter system labeling dopaminergic neurons reveals potential regulatory role for the first intron of the rodent tyrosine hydroxylase gene. 
  • A tyrosine kinase physically associates with the beta-subunit of the human IL-2 receptor. 
  • A tyrosine-phosphorylated protein that binds to an important regulatory region on the cool family of p21-activated kinase-binding proteins. 
  • A uniform human Wnt expression library reveals a shared secretory pathway and unique signaling activities. 
  • A unique chromosomal rearrangement in the Cryptococcus neoformans var. grubii type strain enhances key phenotypes associated with virulence. 
  • A unique pathway for the plasma elimination of alpha 2-antiplasmin-protease complexes in mice. 
  • A unique role for Fyn in CNS myelination. 
  • A unique role of the DNA fragmentation factor in maintaining genomic stability. 
  • A uroguanylin-GUCY2C endocrine axis regulates feeding in mice. 
  • A validated regulatory network for Th17 cell specification. 
  • A vesicular stomatitis virus recombinant expressing granulocyte-macrophage colony-stimulating factor induces enhanced T-cell responses and is highly attenuated for replication in animals. 
  • A vital role for interleukin-21 in the control of a chronic viral infection. 
  • A wireless multi-channel recording system for freely behaving mice and rats. 
  • A20 modulates lipid metabolism and energy production to promote liver regeneration. 
  • A20 protects mice from D-galactosamine/lipopolysaccharide acute toxic lethal hepatitis. 
  • A20 protects mice from lethal liver ischemia/reperfusion injury by increasing peroxisome proliferator-activated receptor-alpha expression. 
  • A20 protects mice from lethal radical hepatectomy by promoting hepatocyte proliferation via a p21waf1-dependent mechanism. 
  • AAV vector-mediated reversal of hypoglycemia in canine and murine glycogen storage disease type Ia. 
  • ABCB5 is a limbal stem cell gene required for corneal development and repair. 
  • ABCG2 and ABCB1 Limit the Efficacy of Dasatinib in a PDGF-B-Driven Brainstem Glioma Model. 
  • ABCs of erythroid mitochondrial iron uptake. 
  • ABI2-deficient mice exhibit defective cell migration, aberrant dendritic spine morphogenesis, and deficits in learning and memory. 
  • ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia. 
  • ABL kinases promote breast cancer osteolytic metastasis by modulating tumor-bone interactions through TAZ and STAT5 signaling. 
  • ACE and ACE2 activity in diabetic mice. 
  • ACE2-mediated reduction of oxidative stress in the central nervous system is associated with improvement of autonomic function. 
  • ACTH receptors in the adrenal: specific binding of ACTH-125I and its relation to adenyl cyclase. 
  • ACTL6A Is Co-Amplified with p63 in Squamous Cell Carcinoma to Drive YAP Activation, Regenerative Proliferation, and Poor Prognosis. 
  • ACVR1 R206H cooperates with H3.1K27M in promoting diffuse intrinsic pontine glioma pathogenesis. 
  • ADAM10 is essential for proteolytic activation of Notch during thymocyte development. 
  • ADAM12: a genetic modifier of preclinical peripheral arterial disease. 
  • ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression. 
  • AID expression during B-cell development: searching for answers. 
  • AJAP1 expression modulates glioma cell motility and correlates with tumor growth and survival. 
  • ALDH activity selectively defines an enhanced tumor-initiating cell population relative to CD133 expression in human pancreatic adenocarcinoma. 
  • ALDH1L2 is the mitochondrial homolog of 10-formyltetrahydrofolate dehydrogenase. 
  • ALK5 phosphorylation of the endoglin cytoplasmic domain regulates Smad1/5/8 signaling and endothelial cell migration. 
  • ALS-associated mutation FUS-R521C causes DNA damage and RNA splicing defects. 
  • ALSUntangled No. 34: GM604. 
  • ALSUntangled No. 35: Hyperbaric Oxygen Therapy. 
  • AMH induces mesonephric cell migration in XX gonads. 
  • AMP-activated kinase reciprocally regulates triacylglycerol synthesis and fatty acid oxidation in liver and muscle: evidence that sn-glycerol-3-phosphate acyltransferase is a novel target. 
  • AMPK and substrate availability regulate creatine transport in cultured cardiomyocytes. 
  • ANG II receptor blockade prevents ventricular hypertrophy and ANF gene expression with pressure overload in mice. 
  • APOE Genotype Differentially Modulates Effects of Anti-Aβ, Passive Immunization in APP Transgenic Mice. 
  • APOE Isoforms Control Pathogenic Subretinal Inflammation in Age-Related Macular Degeneration. 
  • APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress. 
  • APOE genotype affects outcome in a murine model of sepsis: implications for a new treatment strategy. 
  • APOE genotype and an ApoE-mimetic peptide modify the systemic and central nervous system inflammatory response. 
  • APOE genotype-specific differences in human and mouse macrophage nitric oxide production. 
  • APOE genotype-specific differences in the innate immune response. 
  • APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics. 
  • APOE4-VLDL inhibits the HDL-activated phosphatidylinositol 3-kinase/Akt Pathway via the phosphoinositol phosphatase SHIP2. 
  • APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy. 
  • APOL1-G0 or APOL1-G2 Transgenic Models Develop Preeclampsia but Not Kidney Disease. 
  • APRIL and TALL-I and receptors BCMA and TACI: system for regulating humoral immunity. 
  • ARMC4 mutations cause primary ciliary dyskinesia with randomization of left/right body asymmetry. 
  • ASTN2 modulates synaptic strength by trafficking and degradation of surface proteins. 
  • AT1 receptors in the collecting duct directly modulate the concentration of urine. 
  • AT1A angiotensin receptors in the renal proximal tubule regulate blood pressure. 
  • AT2 receptor and vascular smooth muscle cell differentiation in vascular development. 
  • ATAR, a novel tumor necrosis factor receptor family member, signals through TRAF2 and TRAF5. 
  • ATM binds to beta-adaptin in cytoplasmic vesicles. 
  • ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS. 
  • ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. 
  • ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome. 
  • ATP-binding cassette transporter G1 negatively regulates thymocyte and peripheral lymphocyte proliferation. 
  • ATR functions as a gene dosage-dependent tumor suppressor on a mismatch repair-deficient background. 
  • ATR/ATM-mediated phosphorylation of human Rad17 is required for genotoxic stress responses. 
  • Abcc9 is required for the transition to oxidative metabolism in the newborn heart. 
  • Abelson virus abrogation of interleukin-3 dependence in a lymphoid cell line. 
  • Aberrant Otx2 expression enhances migration and induces ectopic proliferation of hindbrain neuronal progenitor cells. 
  • Aberrant methylation and loss of CADM2 tumor suppressor expression is associated with human renal cell carcinoma tumor progression. 
  • Aberrant planar cell polarity induced by urinary tract obstruction. 
  • Aberrant responses in social interaction of dopamine transporter knockout mice. 
  • Abeta42 neurotoxicity in primary co-cultures: effect of apoE isoform and Abeta conformation. 
  • Abi3bp is a multifunctional autocrine/paracrine factor that regulates mesenchymal stem cell biology. 
  • Abl Kinases Regulate HGF/Met Signaling Required for Epithelial Cell Scattering, Tubulogenesis and Motility. 
  • Abl family kinases modulate T cell-mediated inflammation and chemokine-induced migration through the adaptor HEF1 and the GTPase Rap1. 
  • Abl family kinases regulate FcγR-mediated phagocytosis in murine macrophages. 
  • Abl family kinases regulate endothelial barrier function in vitro and in mice. 
  • Abl interactor 1 (Abi-1) wave-binding and SNARE domains regulate its nucleocytoplasmic shuttling, lamellipodium localization, and wave-1 levels. 
  • Abl kinases are required for invadopodia formation and chemokine-induced invasion. 
  • Abl kinases regulate actin comet tail elongation via an N-WASP-dependent pathway. 
  • Abl kinases regulate autophagy by promoting the trafficking and function of lysosomal components. 
  • Abl tyrosine kinases are required for infection by Shigella flexneri. 
  • Abl tyrosine kinases regulate cell-cell adhesion through Rho GTPases. 
  • Abl-interactor-1 (Abi1) has a role in cardiovascular and placental development and is a binding partner of the alpha4 integrin. 
  • Ablation of Sirtuin5 in the postnatal mouse heart results in protein succinylation and normal survival in response to chronic pressure overload. 
  • Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo. 
  • Ablation of dihydroceramide desaturase 1, a therapeutic target for the treatment of metabolic diseases, simultaneously stimulates anabolic and catabolic signaling. 
  • Ablation of dihydroceramide desaturase confers resistance to etoposide-induced apoptosis in vitro. 
  • Ablation of steroid receptor coactivator-3 resembles the human CACT metabolic myopathy. 
  • Abnormal B lymphocyte development, activation, and differentiation in mice that lack or overexpress the CD19 signal transduction molecule. 
  • Abnormal cardiac Na(+) channel properties and QT heart rate adaptation in neonatal ankyrin(B) knockout mice. 
  • Abnormal cerebellar signaling induces dystonia in mice. 
  • Abnormal joint and bone wound healing in hemophilia mice is improved by extending factor IX activity after hemarthrosis. 
  • Abnormal mouse lung alveolarization caused by Smad3 deficiency is a developmental antecedent of centrilobular emphysema. 
  • Abnormal osmotic regulation in trpv4-/- mice. 
  • Abnormal parathyroid function in the X-linked hypophosphatemic mouse. 
  • Abnormal parathyroid hormone stimulation of 25-hydroxyvitamin D-1 alpha-hydroxylase activity in the hypophosphatemic mouse. Evidence for a generalized defect of vitamin D metabolism. 
  • Abnormal production of interleukin-1 by microglia from trisomy 16 mice. 
  • Abnormal regulation of renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity in the X-linked hypophosphatemic mouse. 
  • Abnormal water metabolism in mice lacking the type 1A receptor for ANG II. 
  • Abrogation of adenosine A1 receptor signalling improves metabolic regulation in mice by modulating oxidative stress and inflammatory responses. 
  • Absence of carboxypeptidase E leads to adult hippocampal neuronal degeneration and memory deficits. 
  • Absence of donor MHC antigen expression ameliorates chronic kidney allograft rejection. 
  • Absence of interferon-gamma-inducible gene IGTP does not significantly alter the development of chagasic cardiomyopathy in mice infected with Trypanosoma cruzi (Brazil strain). 
  • Absence of macrophage involvement in the passive serum therapy of Friend leukemia virus-induced disease. 
  • Absence of posttraumatic arthritis following intraarticular fracture in the MRL/MpJ mouse. 
  • Absence of synaptic regulation by phosducin in retinal slices. 
  • Absence of teratogenic effects of progesterone on the developing genital tract of the human female fetus. 
  • Absence of the CAAX endoprotease Rce1: effects on cell growth and transformation. 
  • Absence of the RGS9.Gbeta5 GTPase-activating complex in photoreceptors of the R9AP knockout mouse. 
  • Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. 
  • Absence of tubuloglomerular feedback responses in AT1A receptor-deficient mice. 
  • Abundant androgen regulated mRNAs in mouse submandibular gland: cell-free translation of renin precursor mRNA. 
  • Abundant expression of ponsin, a focal adhesion protein, in lens and downregulation of its expression by impaired cytoskeletal signaling. 
  • Accelerated induction of experimental allergic encephalomyelitis in PL/J mice by a non-V beta 8-specific superantigen. 
  • Accelerated mammary tumor onset in a HER2/Neu mouse model exposed to DDT metabolites locally delivered to the mammary gland. 
  • Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. 
  • Acceleration of mammary neoplasia in transforming growth factor alpha transgenic mice by 7,12-dimethylbenzanthracene. 
  • Accessory subunit KChIP2 modulates the cardiac L-type calcium current. 
  • Accumulation of Ubiquitin and Sequestosome-1 Implicate Protein Damage in Diacetyl-Induced Cytotoxicity. 
  • Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease. 
  • Accumulation of hedgehog-responsive progenitors parallels alcoholic liver disease severity in mice and humans. 
  • Accumulation of natural killer T cells in progressive nonalcoholic fatty liver disease. 
  • Accurate temperature imaging based on intermolecular coherences in magnetic resonance. 
  • Acetaminophen normalizes glucose homeostasis in mouse models for diabetes. 
  • Acetylcholine promotes the proliferation and collagen gene expression of myofibroblastic hepatic stellate cells. 
  • Acetylenics. 2. Synthesis and pharmacology of certain N,N-diakyl-3-phenylpropyn-2-amines. Some analogues with tryptamine-like behavioral effects in mice. 
  • Acquired expression of periostin by human breast cancers promotes tumor angiogenesis through up-regulation of vascular endothelial growth factor receptor 2 expression. 
  • Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors. 
  • Acquisition of response thresholds for timed performance is regulated by a calcium-responsive transcription factor, CaRF. 
  • Acrylic fragmentation in total hip replacements and its biological consequences. 
  • Actin and intermediate filaments stabilize the Chlamydia trachomatis vacuole by forming dynamic structural scaffolds. 
  • Actin cytoskeletal disruption following cryopreservation alters the biodistribution of human mesenchymal stromal cells in vivo. 
  • Actin-related protein2/3 complex regulates tight junctions and terminal differentiation to promote epidermal barrier formation. 
  • Actions of thrombin in the interstitium. 
  • Activated Akt promotes increased resting T cell size, CD28-independent T cell growth, and development of autoimmunity and lymphoma. 
  • Activated B cells modified by electroporation of multiple mRNAs encoding immune stimulatory molecules are comparable to mature dendritic cells in inducing in vitro antigen-specific T-cell responses. 
  • Activated c-Abl is degraded by the ubiquitin-dependent proteasome pathway. 
  • Activated microglia proliferate at neurites of mutant huntingtin-expressing neurons. 
  • Activated protein C preserves functional islet mass after intraportal transplantation: a novel link between endothelial cell activation, thrombosis, inflammation, and islet cell death. 
  • Activated signal transducer and activator of transcription (STAT) 3: localization in focal adhesions and function in ovarian cancer cell motility. 
  • Activating peroxisome proliferator-activated receptor gamma mutant promotes tumor growth in vivo by enhancing angiogenesis. 
  • Activating transcription factor 3 induction in sympathetic neurons after axotomy: response to decreased neurotrophin availability. 
  • Activation and repression of mammalian gene expression by the c-myc protein. 
  • Activation of Akt/PDK signaling in macrophages upon binding of receptor-recognized forms of alpha2-macroglobulin to its cellular receptor: effect of silencing the CREB gene. 
  • Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy. 
  • Activation of Galpha q-coupled signaling pathways in glomerular podocytes promotes renal injury. 
  • Activation of Glutamatergic Fibers in the Anterior NAc Shell Modulates Reward Activity in the aNAcSh, the Lateral Hypothalamus, and Medial Prefrontal Cortex and Transiently Stops Feeding. 
  • Activation of MEF2 by muscle activity is mediated through a calcineurin-dependent pathway. 
  • Activation of NADPH oxidase 1 increases intracellular calcium and migration of smooth muscle cells. 
  • Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. 
  • Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation. 
  • Activation of RalA is critical for Ras-induced tumorigenesis of human cells. 
  • Activation of Slo1 BK channels by Mg2+ coordinated between the voltage sensor and RCK1 domains. 
  • Activation of Wnt signaling in hematopoietic regeneration. 
  • Activation of alloreactive CD8+ T cells operates via CD4-dependent and CD4-independent mechanisms and is CD154 blockade sensitive. 
  • Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis. 
  • Activation of cyclophosphamide for in vitro testing of cell sensitivity. 
  • Activation of delta opioid receptors induces receptor insertion and neuropeptide secretion. 
  • Activation of fibroblast growth factor (FGF) receptors by recombinant human FGF-5. 
  • Activation of glycolysis and apoptosis in glycogen storage disease type Ia. 
  • Activation of hedgehog signaling during fracture repair enhances osteoblastic-dependent matrix formation. 
  • Activation of interleukin 4- and interleukin 6-secreting cells by HIV-specific synthetic peptides. 
  • Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence. 
  • Activation of messenger-independent protein kinases in wild-type and phorbol ester-resistant EL4 thymoma cells. 
  • Activation of mitochondrial biogenesis by heme oxygenase-1-mediated NF-E2-related factor-2 induction rescues mice from lethal Staphylococcus aureus sepsis. 
  • Activation of mitogen-activated protein kinase kinase by v-Raf in NIH 3T3 cells and in vitro. 
  • Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. 
  • Activation of swelling-activated chloride current by tumor necrosis factor-alpha requires ClC-3-dependent endosomal reactive oxygen production. 
  • Activation of the ATF6 branch of the unfolded protein response in neurons improves stroke outcome. 
  • Activation of the NRF2 antioxidant program generates an imbalance in central carbon metabolism in cancer. 
  • Activation of the PD-1 pathway contributes to immune escape in EGFR-driven lung tumors. 
  • Activation of the canonical bone morphogenetic protein (BMP) pathway during lung morphogenesis and adult lung tissue repair. 
  • Activation of the hexosamine pathway causes oxidative stress and abnormal embryo gene expression: involvement in diabetic teratogenesis. 
  • Activation of the integrated stress response during T helper cell differentiation. 
  • Activation of the mTOR Pathway by Oxaliplatin in the Treatment of Colorectal Cancer Liver Metastasis. 
  • Activation of the murine EP3 receptor for PGE2 inhibits cAMP production and promotes platelet aggregation. 
  • Activation of transcription factors activator protein-1 and nuclear factor-kappaB by 2,3,7,8-tetrachlorodibenzo-p-dioxin. 
  • Activation-induced cytidine deaminase expression and activity in the absence of germinal centers: insights into hyper-IgM syndrome. 
  • Activation-induced cytidine deaminase mediates central tolerance in B cells. 
  • Activation-induced endocytosis of the raft-associated transmembrane adaptor protein LAB/NTAL in B lymphocytes: evidence for a role in internalization of the B cell receptor. 
  • Active immunization using dendritic cells mixed with tumor cells inhibits the growth of primary breast cancer. 
  • Active immunization with tumor cells transduced by a novel AAV plasmid-based gene delivery system. 
  • Active immunotherapy of pancreatic cancer with tumor cells genetically engineered to secrete multiple cytokines. 
  • Active immunotherapy with transiently transfected cytokine-secreting tumor cells inhibits breast cancer metastases in tumor-bearing animals. 
  • Active learning of cortical connectivity from two-photon imaging data. 
  • Active staining of mouse embryos for magnetic resonance microscopy. 
  • Activin enhances skin tumourigenesis and malignant progression by inducing a pro-tumourigenic immune cell response. 
  • Activity and cellular functions of the deubiquitinating enzyme and polyglutamine disease protein ataxin-3 are regulated by ubiquitination at lysine 117. 
  • Activity and stability of recombinant bifunctional rearranged and monofunctional domains of ATP-sulfurylase and adenosine 5'-phosphosulfate kinase. 
  • Activity level, apoptosis, and development of cachexia in Apc(Min/+) mice. 
  • Activity of 9-dimethylaminomethyl-10-hydroxycamptothecin against pediatric and adult central nervous system tumor xenografts. 
  • Activity of VNP40101M (Cloretazine) in the treatment of CNS tumor xenografts in athymic mice. 
  • Activity of a Py-Im polyamide targeted to the estrogen response element. 
  • Activity of and effect of subcutaneous treatment with the broad-spectrum antiviral lectin griffithsin in two laboratory rodent models. 
  • Activity of irofulven (6-hydroxymethylacylfulvene) in the treatment of glioblastoma multiforme-derived xenografts in athymic mice. 
  • Activity of temozolomide in the treatment of central nervous system tumor xenografts. 
  • Activity-dependent expression of ELAV/Hu RBPs and neuronal mRNAs in seizure and cocaine brain. 
  • Activity-dependent expression of RNA binding protein HuD and its association with mRNAs in neurons. 
  • Activity-induced remodeling of olfactory bulb microcircuits revealed by monosynaptic tracing. 
  • Acute DNA damage activates the tumour suppressor p53 to promote radiation-induced lymphoma. 
  • Acute and chronic B cell depletion disrupts CD4+ and CD8+ T cell homeostasis and expansion during acute viral infection in mice. 
  • Acute endotoxin-induced thymic atrophy is characterized by intrathymic inflammatory and wound healing responses. 
  • Acute ethanol administration downregulates human immunodeficiency virus-1 glycoprotein 120-induced KC and RANTES production by murine Kupffer cells and splenocytes. 
  • Acute graft-vs-host disease: pathobiology and management. 
  • Acute in vivo genetic rescue demonstrates that phosphorylation of RIM1alpha serine 413 is not required for mossy fiber long-term potentiation. 
  • Acute joint pathology and synovial inflammation is associated with increased intra-articular fracture severity in the mouse knee. 
  • Acute morphine activates satellite glial cells and up-regulates IL-1β in dorsal root ganglia in mice via matrix metalloprotease-9. 
  • Acute morphine induces matrix metalloproteinase-9 up-regulation in primary sensory neurons to mask opioid-induced analgesia in mice. 
  • Acute organ failure following the loss of anti-apoptotic cellular FLICE-inhibitory protein involves activation of innate immune receptors. 
  • Acute pancreatitis induces FasL gene expression and apoptosis in the liver. 
  • Acute reactogenicity after intramuscular immunization with recombinant vesicular stomatitis virus is linked to production of IL-1β. 
  • Acute tissue injury activates satellite cells and promotes sarcoma formation via the HGF/c-MET signaling pathway. 
  • Acute tubular necrosis. An experimental model detailing the biochemical events accompanying renal injury and recovery. 
  • Acyl derivatives of demethylpenclomedine, an antitumor-active, non-neurotoxic metabolites of penclomedine. 
  • Acylation of Superoxide Dismutase 1 (SOD1) at K122 Governs SOD1-Mediated Inhibition of Mitochondrial Respiration. 
  • Ad-IRF-1 induces apoptosis in esophageal adenocarcinoma. 
  • Adam10 is essential for early embryonic cardiovascular development. 
  • Adaptation after small bowel resection is attenuated by sialoadenectomy: the role for endogenous epidermal growth factor. 
  • Adaptation in a mouse colony monoassociated with Escherichia coli K-12 for more than 1,000 days. 
  • Adaptation of an ICAM-1-tropic enterovirus to the mouse respiratory tract. 
  • Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism. 
  • Adaptive evolution drives the diversification of zinc-finger binding domains. 
  • Adaptive mechanisms that preserve cardiac function in mice without myoglobin. 
  • Adaptive resistance to therapeutic PD-1 blockade is associated with upregulation of alternative immune checkpoints. 
  • Addition of a second, different allogeneic graft accelerates white cell and platelet engraftment after T-cell-depleted bone marrow transplantation. 
  • Additive and synergistic interactions of monoclonal antibodies and immunotoxins reactive with breast and ovarian cancer. 
  • Additive estrogenic activities of a binary mixture of 2',4',6'-trichloro- and 2',3',4',5'-tetrachloro-4-biphenylol. 
  • Addressing cell-sourcing limitations with gene therapy. 
  • Adeno-associated viral vectors based on serotype 3b use components of the fibroblast growth factor receptor signaling complex for efficient transduction. 
  • Adeno-associated virus serotypes: vector toolkit for human gene therapy. 
  • Adeno-associated virus type 2 contains an integrin alpha5beta1 binding domain essential for viral cell entry. 
  • Adeno-associated virus-delivered artificial microRNA extends survival and delays paralysis in an amyotrophic lateral sclerosis mouse model. 
  • Adeno-associated virus-mediated antiangiogenic gene therapy with thrombospondin-1 type 1 repeats and endostatin. 
  • Adenomas induced by polycyclic aromatic hydrocarbons in strain A/J mouse lung correlate with time-integrated DNA adduct levels. 
  • Adenosine-deaminase-deficient mice die perinatally and exhibit liver-cell degeneration, atelectasis and small intestinal cell death. 
  • Adenoviral expression of NHERF-1 in NHERF-1 null mouse renal proximal tubule cells restores Npt2a regulation by low phosphate media and parathyroid hormone. 
  • Adenoviral infection induces a multi-faceted innate cellular immune response that is mediated by the toll-like receptor pathway in A549 cells. 
  • Adenovirus 12S E1A gene represses differentiation of F9 teratocarcinoma cells. 
  • Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation. 
  • Adenovirus F protein as a delivery vehicle for botulinum B. 
  • Adenovirus capsid-display of the retro-oriented human complement inhibitor DAF reduces Ad vector-triggered immune responses in vitro and in vivo. 
  • Adenovirus infection of differentiated F9 cells results in a global shut-off of differentiation-induced gene expression. 
  • Adenovirus infection triggers a rapid, MyD88-regulated transcriptome response critical to acute-phase and adaptive immune responses in vivo. 
  • Adenovirus vector induced innate immune responses: impact upon efficacy and toxicity in gene therapy and vaccine applications. 
  • Adenovirus-mediated antisense urokinase-type plasminogen activator receptor gene transfer reduces tumor cell invasion and metastasis in non-small cell lung cancer cell lines. 
  • Adenovirus-mediated transfer of CCAAT/enhancer-binding protein-alpha identifies a dominant antiproliferative role for this isoform in hepatocytes. 
  • Adenylate cyclase 7 is implicated in the biology of depression and modulation of affective neural circuitry. 
  • Adenylate cyclase toxin (ACT) from Bordetella hinzii: characterization and differences from ACT of Bordetella pertussis. 
  • Adhesion to osteopontin in the bone marrow niche regulates lymphoblastic leukemia cell dormancy. 
  • Adipogenic and lipolytic effects of chronic glucocorticoid exposure. 
  • Adipose acyl-CoA synthetase-1 directs fatty acids toward beta-oxidation and is required for cold thermogenesis. 
  • Adipose tissue branched chain amino acid (BCAA) metabolism modulates circulating BCAA levels. 
  • Adipose-specific deletion of TFAM increases mitochondrial oxidation and protects mice against obesity and insulin resistance. 
  • Adiposity-related protection of intestinal tumorigenesis: interaction with dietary calcium. 
  • Adjunctive β2-agonist treatment reduces glycogen independently of receptor-mediated acid α-glucosidase uptake in the limb muscles of mice with Pompe disease. 
  • Adjunctive β2-agonists reverse neuromuscular involvement in murine Pompe disease. 
  • Adjuvanticity and protective immunity of Plasmodium yoelii nigeriensis blood-stage soluble antigens encapsulated in fusogenic liposome. 
  • Administration of a CD31-derived peptide delays the onset and significantly increases survival from lethal graft-versus-host disease. 
  • Adoptive transfer of cytotoxic T lymphocytes for the treatment of transplant-associated lymphoma. 
  • Adoptively transferred ex vivo expanded gammadelta-T cells mediate in vivo antitumor activity in preclinical mouse models of breast cancer. 
  • Adrenergic Stimulation of DUSP1 Impairs Chemotherapy Response in Ovarian Cancer. 
  • Adrenergic regulation of monocyte chemotactic protein 1 leads to enhanced macrophage recruitment and ovarian carcinoma growth. 
  • Adrenoceptors, uncoupling proteins, and energy expenditure. 
  • Adrenocorticotropic hormone directly stimulates testosterone production by the fetal and neonatal mouse testis. 
  • Adult enteric nervous system in health is maintained by a dynamic balance between neuronal apoptosis and neurogenesis. 
  • Adult murine hippocampal neurogenesis is inhibited by sustained IL-1β and not rescued by voluntary running. 
  • Adult renal mesenchymal stem cell-like cells contribute to juxtaglomerular cell recruitment. 
  • Advanced glycation end-product of low density lipoprotein activates the toll-like 4 receptor pathway implications for diabetic atherosclerosis. 
  • Advanced magnetic resonance imaging of cerebral cavernous malformations: part II. Imaging of lesions in murine models. 
  • Advances in understanding the urine-concentrating mechanism. 
  • Advantages of mRNA amplification for microarray analysis. 
  • Adverse effects of constitutively active alpha(1B)-adrenergic receptors after pressure overload in mouse hearts. 
  • Adynamic Bone Decreases Bone Toughness During Aging by Affecting Mineral and Matrix. 
  • Aerobic exercise attenuates airway inflammatory responses in a mouse model of atopic asthma. 
  • Aerobic training as an adjunctive therapy to enzyme replacement in Pompe disease. 
  • Affinity-matured anti-glycoprotein NMB recombinant immunotoxins targeting malignant gliomas and melanomas. 
  • Affinity-matured recombinant immunotoxin targeting gangliosides 3'-isoLM1 and 3',6'-isoLD1 on malignant gliomas. 
  • Age as an independent risk factor for severity of experimental choroidal neovascularization. 
  • Age related changes in blood-to-brain amino acid transport and incorporation into brain protein. 
  • Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis. 
  • Age-dependent alterations of peritoneal exudate macrophages in autoimmune-prone and autoimmune-resistant mouse strains. 
  • Age-dependent hepatic lymphoid organization directs successful immunity to hepatitis B. 
  • Age-dependent requirement for gammadelta T cells in the primary but not secondary protective immune response against an intestinal parasite. 
  • Age-dependent retinal iron accumulation and degeneration in hepcidin knockout mice. 
  • Age-dependent sexual dimorphism in cognition and stress response in the 3xTg-AD mice. 
  • Age-related changes in the cellular composition and epithelial organization of the mouse trachea. 
  • Age-related changes in visual function in cystathionine-beta-synthase mutant mice, a model of hyperhomocysteinemia. 
  • Age-related declines in α-Klotho drive progenitor cell mitochondrial dysfunction and impaired muscle regeneration. 
  • Age-related efficacy with an AAV vector in Fabry disease mice. 
  • Age-related relationship between mRNA expression of GABA(B) receptors and calcium channel beta4 subunits in cacnb4lh mice. 
  • Aggresome disruption: a novel strategy to enhance bortezomib-induced apoptosis in pancreatic cancer cells. 
  • Aggressive fibromatosis (desmoid tumor) is derived from mesenchymal progenitor cells. 
  • Aging and neoplasia. 
  • Aging and reactivation of latent murine cytomegalovirus. 
  • Aging-related atherosclerosis is exacerbated by arterial expression of tumor necrosis factor receptor-1: evidence from mouse models and human association studies. 
  • Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C. 
  • Agonist-dependent recruitment of phosphoinositide 3-kinase to the membrane by beta-adrenergic receptor kinase 1. A role in receptor sequestration. 
  • Agonist-specific regulation of delta-opioid receptor trafficking by G protein-coupled receptor kinase and beta-arrestin. 
  • Agonist/endogenous peptide-MHC heterodimers drive T cell activation and sensitivity. 
  • Agonists of G-Protein-Coupled Odorant Receptors Are Predicted from Chemical Features. 
  • Airway epithelial cell expression of interleukin-6 in transgenic mice. Uncoupling of airway inflammation and bronchial hyperreactivity. 
  • Airway epithelial progenitors are region specific and show differential responses to bleomycin-induced lung injury. 
  • Airway inflammation and remodeling in asthma. Lessons from interleukin 11 and interleukin 13 transgenic mice. 
  • Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide. 
  • Airway injury in lung disease pathophysiology: selective depletion of airway stem and progenitor cell pools potentiates lung inflammation and alveolar dysfunction. 
  • Airway smooth muscle dysfunction in Pompe (Gaa-/- ) mice. 
  • Airway smooth muscle relaxation is impaired in mice lacking the p47phox subunit of NAD(P)H oxidase. 
  • Airway-specific inducible transgene expression using aerosolized doxycycline. 
  • Akt activation protects hippocampal neurons from apoptosis by inhibiting transcriptional activity of p53. 
  • Akt is required for Stat5 activation and mammary differentiation. 
  • Akt requires glucose metabolism to suppress puma expression and prevent apoptosis of leukemic T cells. 
  • Akt-dependent glucose metabolism promotes Mcl-1 synthesis to maintain cell survival and resistance to Bcl-2 inhibition. 
  • Akt-directed glucose metabolism can prevent Bax conformation change and promote growth factor-independent survival. 
  • Akt/protein kinase B promotes organ growth in transgenic mice. 
  • Akt1 and Akt2 are required for alphabeta thymocyte survival and differentiation. 
  • Akt1 and Akt2 promote peripheral B-cell maturation and survival. 
  • Al-Cu-Fe quasicrystal/ultra-high molecular weight polyethylene composites as biomaterials for acetabular cup prosthetics. 
  • Aldehyde dehydrogenase inhibition blocks mucosal fibrosis in human and mouse ocular scarring. 
  • Aldosterone Exposure Causes Increased Retinal Edema and Severe Retinopathy Following Laser-Induced Retinal Vein Occlusion in Mice. 
  • Aldosterone, ion channels, and sudden death: another piece of the circle? 
  • Aldosterone-Induced Vascular Remodeling and Endothelial Dysfunction Require Functional Angiotensin Type 1a Receptors. 
  • Aldosterone-induced activation of signaling pathways requires activity of angiotensin type 1a receptors. 
  • Alginate encapsulation is a highly reproducible method for tumor cell implantation in dorsal skinfold chambers. 
  • Aligning animal models with clinical epilepsy: where to begin? 
  • Allele separation facilitates interpretation of potential splicing alterations and genomic rearrangements. 
  • Allele-specific regulation of TCR beta variable gene segment chromatin structure. 
  • Allelic Imbalance Is a Prevalent and Tissue-Specific Feature of the Mouse Transcriptome. 
  • Allelic exclusion of mouse T cell receptor alpha chains occurs at the time of thymocyte TCR up-regulation. 
  • Allelic exclusion of the T cell receptor alpha-chain: developmental regulation of a post-translational event. 
  • Allelic exclusion of the TCR alpha-chain is an active process requiring TCR-mediated signaling and c-Cbl. 
  • Allergen-induced airway disease is mouse strain dependent. 
  • Allergic inflammation induces a persistent mechanistic switch in thromboxane-mediated airway constriction in the mouse. 
  • Allergic lung responses are increased in prostaglandin H synthase-deficient mice. 
  • Allocation of epiblast cells to germ layer derivatives during mouse gastrulation as studied with a retroviral vector. 
  • Allogeneic Stem-Cell Transplantation - A T-Cell Balancing ACT. 
  • Allogeneic memory T cell response. 
  • Allogeneic splenocyte transfer and lipopolysaccharide inhalations induce differential T cell expansion and lung injury: a novel model of pulmonary graft-versus-host disease. 
  • Allograft rejection by primed/memory CD8+ T cells is CD154 blockade resistant: therapeutic implications for sensitized transplant recipients. 
  • Alloimmune lung injury induced by local innate immune activation through inhaled lipopolysaccharide. 
  • Allospecific CD4(+) effector memory T cells do not induce graft-versus-host disease in mice. 
  • Alopecia in IL-10-deficient mouse pups is c-kit-dependent and can be triggered by iron deficiency. 
  • Alpha 2 macroglobulin-proteinase complexes stimulate prostaglandin E2 synthesis by peritoneal macrophages. 
  • Alpha 2-macroglobulin 'fast' forms inhibit superoxide production by activated macrophages. 
  • Alpha 2-macroglobulin binds CpG oligodeoxynucleotides and enhances their immunostimulatory properties by a receptor-dependent mechanism. 
  • Alpha-internexin is structurally and functionally associated with the neurofilament triplet proteins in the mature CNS. 
  • Alpha-melanocyte-stimulating hormone suppresses antigen-stimulated T cell production of gamma-interferon. 
  • Alphavirus replicon particles acting as adjuvants promote CD8+ T cell responses to co-delivered antigen. 
  • Alphavirus replicon particles as candidate HIV vaccines. 
  • Alprazolam reduces stress hyperglycemia in ob/ob mice. 
  • Alteration of IGF system gene expression during the postnatal development of pcd mice. 
  • Alteration of pulmonary neuroendocrine cells during epithelial repair of naphthalene-induced airway injury. 
  • Alterations in PKCgamma in the mouse hippocampus after prenatal exposure to heroin: a link from cell signaling to behavioral outcome. 
  • Alterations in calcium channel currents underlie defective insulin secretion in a transgenic mouse. 
  • Alterations in calcium metabolism in murine macrophages by the benzene metabolite 1,4-benzoquinone. 
  • Alterations in cardiac adrenergic signaling and calcium cycling differentially affect the progression of cardiomyopathy. 
  • Alterations in inorganic phosphate in mouse hindlimb muscles during limb disuse. 
  • Alterations in skeletal muscle fatty acid handling predisposes middle-aged mice to diet-induced insulin resistance. 
  • Alterations in slow-twitch muscle phenotype in transgenic mice overexpressing the Ca2+ buffering protein parvalbumin. 
  • Alterations of excitatory amino acid receptors in the brain of manganese-treated mice. 
  • Altered B lymphocyte function induces systemic autoimmunity in systemic sclerosis. 
  • Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes. 
  • Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities. 
  • Altered V-ATPase expression in renal intercalated cells isolated from B1 subunit-deficient mice by fluorescence-activated cell sorting. 
  • Altered airway and cardiac responses in mice lacking G protein-coupled receptor kinase 3. 
  • Altered blood pressure responses and normal cardiac phenotype in ACE2-null mice. 
  • Altered cAMP levels in retinas from transgenic mice expressing a rhodopsin mutant. 
  • Altered cell-averaged microviscosity of murine peritoneal macrophages undergoing activation in vivo or in vitro. 
  • Altered clearance of human alpha 2-macroglobulin complexes following reaction with cis-dichlorodiamineplatinum(II). 
  • Altered distribution of H60 minor H antigen-specific CD8 T cells and attenuated chronic vasculopathy in minor histocompatibility antigen mismatched heart transplantation in Cxcr3-/- mouse recipients. 
  • Altered distribution of mitochondria and actin fibers in 3T3 cells cultured on microcarriers. 
  • Altered expression of extracellular superoxide dismutase in mouse lung after bleomycin treatment. 
  • Altered expression of ganglioside phenotypes of human gliomas in vivo and in vitro. 
  • Altered expression of methylenetetrahydrofolate reductase modifies response to methotrexate in mice. 
  • Altered growth of a human neuroendocrine carcinoma line after transfection of a major histocompatibility complex class I gene. 
  • Altered hepatic lymphocyte subpopulations in obesity-related murine fatty livers: potential mechanism for sensitization to liver damage. 
  • Altered immune responses in apolipoprotein E-deficient mice. 
  • Altered inflammatory responses in leukotriene-deficient mice. 
  • Altered interaction of Cis-dichlorodiammineplatinum(II)--modified alpha 2-macroglobulin (alpha 2M) with the low density lipoprotein receptor-related protein/alpha 2M receptor but not the alpha 2M signaling receptor. 
  • Altered intragraft immune responses and improved renal function in MHC class II-deficient mouse kidney allografts. 
  • Altered localization of choline transporter sites in the mouse hippocampus after prenatal heroin exposure. 
  • Altered lung gene expression in CCSP-null mice suggests immunoregulatory roles for Clara cells. 
  • Altered mGluR5-Homer scaffolds and corticostriatal connectivity in a Shank3 complete knockout model of autism. 
  • Altered morphology of hippocampal dentate granule cell presynaptic and postsynaptic terminals following conditional deletion of TrkB. 
  • Altered phenotypic gene expression of 10T1/2 mesenchymal cells in nonuniformly stretched PEGDA hydrogels. 
  • Altered pulmonary response to hyperoxia in Clara cell secretory protein deficient mice. 
  • Altered regulation of brain-derived neurotrophic factor protein in hippocampus following slice preparation. 
  • Altered stored calcium release in skeletal myotubes deficient of triadin and junctin. 
  • Altered surfactant function and structure in SP-A gene targeted mice. 
  • Altered synthesis of the 26-kDa heat stress protein family and thermotolerance in cell lines with elevated levels of calcium-binding proteins. 
  • Altered toll-like receptor responsiveness underlies a dominant heritable defect in B cell tolerance in autoimmune New Zealand Black mice. 
  • Altered trabecular bone structure and delayed cartilage degeneration in the knees of collagen VI null mice. 
  • Altered ultrasonic vocalization and impaired learning and memory in Angelman syndrome mouse model with a large maternal deletion from Ube3a to Gabrb3. 
  • Altered urinary bladder function in mice lacking the vanilloid receptor TRPV1. 
  • Altered wound healing in mice lacking a functional osteopontin gene (spp1). 
  • Altering and assessing persistence of genetically modified E. coli MG1655 in the large bowel. 
  • Alternative Splicing of EZH2 pre-mRNA by SF3B3 Contributes to the Tumorigenic Potential of Renal Cancer. 
  • Alternative pathways for the selection of antigen-specific peripheral T cells. 
  • Alternative processing of androgen-binding protein RNA transcripts in fetal rat liver. Identification of a transcript formed by trans splicing. 
  • Alternative splicing in Acad8 resulting a mitochondrial defect and progressive hepatic steatosis in mice. 
  • Alternative splicing of fibroblast growth factor receptor 2 (FGF-R2) in human prostate cancer. 
  • Alternative splicing of the GABA(A) receptor alpha 4 subunit creates a severely truncated mRNA. 
  • Alternative splicing promotes tumour aggressiveness and drug resistance in African American prostate cancer. 
  • Alternative splicing: a mechanism for phenotypic rescue of a common inherited defect. 
  • Aluminum-induced DNA synthesis in osteoblasts: mediation by a G-protein coupled cation sensing mechanism. 
  • Alveolar macrophage apoptosis and TNF-alpha, but not p53, expression correlate with murine response to bleomycin. 
  • Alveolar proteinosis: a disease of mice and men. 
  • Alveolar rhabdomyosarcoma-associated PAX3-FOXO1 promotes tumorigenesis via Hippo pathway suppression. 
  • Alveolar septal structure in different species. 
  • Ambient ozone primes pulmonary innate immunity in mice. 
  • Amelioration of collagen-induced arthritis by CD95 (Apo-1/Fas)-ligand gene transfer. 
  • Amelioration of inflammatory arthritis by targeting the pre-ligand assembly domain of tumor necrosis factor receptors. 
  • Amelioration of the behavioral phenotype in genetically ataxic mice through bilateral intracerebellar grafting of fetal Purkinje cells. 
  • Amenable epigenetic traits of dental pulp stem cells underlie high capability of xeno-free episomal reprogramming. 
  • Amino acid determinants for NMDA receptor inhibition by conantokin-T. 
  • Amino acids stimulate cholecystokinin release through the Ca2+-sensing receptor. 
  • Aminoaciduria and altered renal expression of luminal amino acid transporters in mice lacking novel gene collectrin. 
  • Amniocytes can serve a dual function as a source of iPS cells and feeder layers. 
  • Amphiregulin-dependent mucous cell metaplasia in a model of nonallergic lung injury. 
  • Amplification and expression of the epidermal growth factor receptor gene in human glioma xenografts. 
  • Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin. 
  • Amplification of the c-myc gene in human medulloblastoma cell lines and xenografts. 
  • Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice. 
  • Amyloid precursor protein and amyloid beta-peptide bind to ATP synthase and regulate its activity at the surface of neural cells. 
  • Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. 
  • Amyloid-beta1-42 reduces neuronal excitability in mouse dentate gyrus. 
  • Amyloid-β oligomers induce synaptic damage via Tau-dependent microtubule severing by TTLL6 and spastin. 
  • An AOTF-based dual-modality hyperspectral imaging system (DMHSI) capable of simultaneous fluorescence and reflectance imaging. 
  • An Adeno-Associated Virus-Based Toolkit for Preferential Targeting and Manipulating Quiescent Neural Stem Cells in the Adult Hippocampus. 
  • An Akt/beta-arrestin 2/PP2A signaling complex mediates dopaminergic neurotransmission and behavior. 
  • An Ectopic CTCF Binding Element Inhibits Tcrd Rearrangement by Limiting Contact between Vδ and Dδ Gene Segments. 
  • An Embryonic and Induced Pluripotent Stem Cell Model for Ovarian Granulosa Cell Development and Steroidogenesis. 
  • An Engineered Optogenetic Switch for Spatiotemporal Control of Gene Expression, Cell Differentiation, and Tissue Morphogenesis. 
  • An FGF autocrine loop initiated in second heart field mesoderm regulates morphogenesis at the arterial pole of the heart. 
  • An FGF-WNT gene regulatory network controls lung mesenchyme development. 
  • An HMGA2-IGF2BP2 axis regulates myoblast proliferation and myogenesis. 
  • An Hfe-dependent pathway mediates hyposideremia in response to lipopolysaccharide-induced inflammation in mice. 
  • An Islet-Targeted Genome-Wide Association Scan Identifies Novel Genes Implicated in Cytokine-Mediated Islet Stress in Type 2 Diabetes. 
  • An L-selectin ligand distinct from P-selectin glycoprotein ligand-1 is expressed on endothelial cells and promotes neutrophil rolling in inflammation. 
  • An N-ethyl-N-nitrosourea mutagenesis recessive screen identifies two candidate regions for murine cardiomyopathy that map to chromosomes 1 and 15. 
  • An N-ethyl-N-nitrosourea mutagenesis screen for epigenetic mutations in the mouse. 
  • An NLRP3 Mutation Causes Arthropathy and Osteoporosis in Humanized Mice. 
  • An SSLP marker-anchored BAC framework map of the mouse genome. 
  • An aberrant SREBP-dependent lipogenic program promotes metastatic prostate cancer. 
  • An activated factor VII variant with enhanced tissue factor-independent activity speeds wound healing in a mouse hemophilia B model. 
  • An adenoviral vaccine encoding full-length inactivated human Her2 exhibits potent immunogenicty and enhanced therapeutic efficacy without oncogenicity. 
  • An alanine residue in the M3-M4 linker lines the glycine binding pocket of the N-methyl-D-aspartate receptor. 
  • An alternative and effective HIV vaccination approach based on inhibition of antigen presentation attenuators in dendritic cells. 
  • An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus. 
  • An analysis of licking microstructure in three strains of mice. 
  • An analysis of the uncertainty and bias in DCE-MRI measurements using the spoiled gradient-recalled echo pulse sequence. 
  • An animal model of MYC-driven medulloblastoma. 
  • An animal model of attention deficit hyperactivity disorder. 
  • An ankyrin-based mechanism for functional organization of dystrophin and dystroglycan. 
  • An anti-silencer- and SATB1-dependent chromatin hub regulates Rag1 and Rag2 gene expression during thymocyte development. 
  • An anxiety-like phenotype in mice selectively bred for aggression. 
  • An apoE-derived mimic peptide, COG1410, alleviates early brain injury via reducing apoptosis and neuroinflammation in a mouse model of subarachnoid hemorrhage. 
  • An apolipoprotein E-based therapeutic improves outcome and reduces Alzheimer's disease pathology following closed head injury: evidence of pharmacogenomic interaction. 
  • An apolipoprotein E-mimetic stimulates axonal regeneration and remyelination after peripheral nerve injury. 
  • An apoptotic model for nitrosative stress. 
  • An assay for X inactivation based on differential methylation at the fragile X locus, FMR1. 
  • An ear punch model for studying the effect of radiation on wound healing. 
  • An effective AIDS vaccine based on live attenuated vesicular stomatitis virus recombinants. 
  • An efficient MR image reconstruction method for arbitrary K-space trajectories without density compensation. 
  • An efficient multiple-exposure analysis of the toxicity of crisnatol, a DNA intercalator in phase II clinical trials. 
  • An encyclopedia of mouse DNA elements (Mouse ENCODE). 
  • An endogenous TNF-alpha antagonist induced by splice-switching oligonucleotides reduces inflammation in hepatitis and arthritis mouse models. 
  • An endogenous positively selecting peptide enhances mature T cell responses and becomes an autoantigen in the absence of microRNA miR-181a. 
  • An engineered vascular endothelial growth factor-activating transcription factor induces therapeutic angiogenesis in ApoE knockout mice with hindlimb ischemia. 
  • An enteroendocrine cell-enteric glia connection revealed by 3D electron microscopy. 
  • An entirely cell-based system to generate single-chain antibodies against cell surface receptors. 
  • An essential function for the calcium-promoted Ras inactivator in Fcgamma receptor-mediated phagocytosis. 
  • An essential role for Prox1 in the induction of the lymphatic endothelial cell phenotype. 
  • An essential role for RasGRP1 in mast cell function and IgE-mediated allergic response. 
  • An essential role for a MEK-C/EBP pathway during growth factor-regulated cortical neurogenesis. 
  • An essential role for an inositol polyphosphate multikinase, Ipk2, in mouse embryogenesis and second messenger production. 
  • An essential role for c-FLIP in the efficient development of mature T lymphocytes. 
  • An essential role for mitochondrial aldehyde dehydrogenase in nitroglycerin bioactivation. 
  • An essential role for the Glut1 PDZ-binding motif in growth factor regulation of Glut1 degradation and trafficking. 
  • An essential role of Bmp4 in the atrioventricular septation of the mouse heart. 
  • An extracellular biochemical screen reveals that FLRTs and Unc5s mediate neuronal subtype recognition in the retina. 
  • An imaging-based approach to identify ligands for olfactory receptors. 
  • An immunoglobulin C kappa-reactive single chain antibody fusion protein induces tolerance through receptor editing in a normal polyclonal immune system. 
  • An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. 
  • An in vitro assay procedure to test chemotherapeutic drugs on cells from human solid tumors. 
  • An in vivo model to quantify motor and sensory peripheral nerve regeneration using bioresorbable nerve guide tubes. 
  • An inhibitor of IkappaB kinase, BMS-345541, blocks endothelial cell adhesion molecule expression and reduces the severity of dextran sulfate sodium-induced colitis in mice. 
  • An inhibitor of macrophage chemotaxis produced by neoplasms. 
  • An inhibitor of nuclear scaffold protease blocks chemical transformation of fibroblasts. 
  • An injectable method for noninvasive spine fusion. 
  • An integrated widefield imaging and spectroscopy system for contrast-enhanced, image-guided resection of tumors. 
  • An integrative model of mouse cardiac electrophysiology from cell to torso. 
  • An interaction between L-prostaglandin D synthase and arrestin increases PGD2 production. 
  • An interdomain interaction of the androgen receptor is required for its aggregation and toxicity in spinal and bulbar muscular atrophy. 
  • An interlaboratory comparison of dosimetry for a multi-institutional radiobiological research project: Observations, problems, solutions and lessons learned. 
  • An internalization signal in the simian immunodeficiency virus transmembrane protein cytoplasmic domain modulates expression of envelope glycoproteins on the cell surface. 
  • An intracellular role for ABCG1-mediated cholesterol transport in the regulated secretory pathway of mouse pancreatic beta cells. 
  • An intrinsic neuronal defect operates in dystonia musculorum: a study of dt/dt<==>+/+ chimeras. 
  • An intron facilitates activation of the calspermin gene by the testis-specific transcription factor CREM tau. 
  • An investigation of hemopexin redox properties by spectroelectrochemistry: biological relevance for heme uptake. 
  • An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. 
  • An oncogenic KRAS2 expression signature identified by cross-species gene-expression analysis. 
  • An opposite role for tau in circadian rhythms revealed by mathematical modeling. 
  • An oxidized extracellular oxidation-reduction state increases Nox1 expression and proliferation in vascular smooth muscle cells via epidermal growth factor receptor activation. 
  • An ultrastructural study of C-type virion assembly in mouse cells. 
  • An unbiased in vivo functional genomics screening approach in mice identifies novel tumor cell-based regulators of immune rejection. 
  • Anabolic effects of a G protein-coupled receptor kinase inhibitor expressed in osteoblasts. 
  • Anabolic function of the type II isozyme of hexokinase in hepatic lipid synthesis. 
  • Anabolism-Associated Mitochondrial Stasis Driving Lymphocyte Differentiation over Self-Renewal. 
  • Analysis of ALDH1A2, CYP26A1, CYP26B1, CRABP1, and CRABP2 in human neural tube defects suggests a possible association with alleles in ALDH1A2. 
  • Analysis of DNA damage and repair in nuclear and mitochondrial DNA of animal cells using quantitative PCR. 
  • Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations. 
  • Analysis of T-cell differentiation antigens in acute lymphatic leukemia using monoclonal antibodies. 
  • Analysis of TRPV channel activation by stimulation of FCεRI and MRGPR receptors in mouse peritoneal mast cells. 
  • Analysis of a food-borne fungal pathogen outbreak: virulence and genome of a Mucor circinelloides isolate from yogurt. 
  • Analysis of changes in SUMO-2/3 modification during breast cancer progression and metastasis. 
  • Analysis of corneal and conjunctival microenvironments using monoclonal antibodies. 
  • Analysis of expression of multiple genes encoding calmodulin during spermatogenesis. 
  • Analysis of gene mutations and clastogenicity following short-term treatment with azathioprine in MutaMouse. 
  • Analysis of human innate immune responses to PRINT fabricated nanoparticles with cross validation using a humanized mouse model. 
  • Analysis of left ventricular hemodynamics in physiological hyperspace. 
  • Analysis of long range correlations due to coherent light scattering from in-vitro cell arrays using angle-resolved low coherence interferometry. 
  • Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells. 
  • Analysis of messenger ribonucleic acid and protein for the ligands and receptors of the platelet-derived growth factor signaling pathway in the placenta, extraembryonic membranes, and uterus during the latter half of murine gestation. 
  • Analysis of multi-arm tumor growth trials in xenograft animals using phase change adaptive piecewise quadratic models. 
  • Analysis of muscle creatine kinase regulatory elements in recombinant adenoviral vectors. 
  • Analysis of neurogenesis in a mammalian neuroepithelium: proliferation and differentiation of an olfactory neuron precursor in vitro. 
  • Analysis of oxygen/glucose-deprivation-induced changes in SUMO3 conjugation using SILAC-based quantitative proteomics. 
  • Analysis of phosphatases in ER-negative breast cancers identifies DUSP4 as a critical regulator of growth and invasion. 
  • Analysis of recombinant Phex: an endopeptidase in search of a substrate. 
  • Analysis of regulatory CD8 T cells in Qa-1-deficient mice. 
  • Analysis of repetitive sequence elements containing tRNA-like sequences. 
  • Analysis of the E399D mutation in SLC11A2. 
  • Analysis of the Rab GTPase Interactome in Dendritic Cells Reveals Anti-microbial Functions of the Rab32 Complex in Bacterial Containment. 
  • Analysis of the biologic properties of p230 Bcr-Abl reveals unique and overlapping properties with the oncogenic p185 and p210 Bcr-Abl tyrosine kinases. 
  • Analysis of the effect of natural sequence variation in Tat and in cyclin T on the formation and RNA binding properties of Tat-cyclin T complexes. 
  • Analysis of the linker for activation of T cells and the linker for activation of B cells in natural killer cells reveals a novel signaling cassette, dual usage in ITAM signaling, and influence on development of the Ly49 repertoire. 
  • Analysis of the mouse transcriptome based on functional annotation of 60,770 full-length cDNAs. 
  • Analysis of the mouse transcriptome for genes involved in the function of the nervous system. 
  • Analysis of the relationship between stage of differentiation and NK/LAK susceptibility of colon carcinoma cells. 
  • Analysis of the role of E2A-encoded proteins in insulin gene transcription. 
  • Analysis of the role of membrane polarity in polycystic kidney disease of transgenic SBM mice. 
  • Analysis of the stimulatory effect of splicing on mRNA production and utilization in mammalian cells. 
  • Analyzing somatosensory axon projections with the sensory neuron-specific Advillin gene. 
  • Anaplastic human gliomas grown in athymic mice. Morphology and glial fibrillary acidic protein expression. 
  • Anatomical and functional imaging of myocardial infarction in mice using micro-CT and eXIA 160 contrast agent. 
  • Anatomy and spatial organization of Müller glia in mouse retina. 
  • Ancestral and consensus envelope immunogens for HIV-1 subtype C. 
  • Anchorage of VEGF to the extracellular matrix conveys differential signaling responses to endothelial cells. 
  • Anchorage-independent cell growth signature identifies tumors with metastatic potential. 
  • Androgen decreases dopamine neurone survival in rat midbrain. 
  • Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers. 
  • Androgen receptor locus on the human X chromosome: regional localization to Xq11-12 and description of a DNA polymorphism. 
  • Androgen-independent prostate cancer progression in the TRAMP model. 
  • Androgen-induced differentiation and tumorigenicity of human prostate epithelial cells. 
  • Androgen-mediated immune function is altered by the apolipoprotein E gene. 
  • Anemia of inflammation: the cytokine-hepcidin link. 
  • Angiogenesis and growth of isografted bone: quantitative in vivo assay in nude mice. 
  • Angiogenesis, microvascular architecture, microhemodynamics, and interstitial fluid pressure during early growth of human adenocarcinoma LS174T in SCID mice. 
  • Angiogenic growth factors in the pathophysiology of a murine model of acute lung injury. 
  • Angiopoietin receptor TEK mutations underlie primary congenital glaucoma with variable expressivity. 
  • Angiopoietin-1 is required for Schlemm's canal development in mice and humans. 
  • Angiopoietin-2 confers Atheroprotection in apoE-/- mice by inhibiting LDL oxidation via nitric oxide. 
  • Angiostatin-like activity of a monoclonal antibody to the catalytic subunit of F1F0 ATP synthase. 
  • Angiotensin AT1B receptor mediates calcium signaling in vascular smooth muscle cells of AT1A receptor-deficient mice. 
  • Angiotensin II Short-Loop Feedback: Is There a Role of Ang II for the Regulation of the Renin System In Vivo? 
  • Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin. 
  • Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. 
  • Angiotensin II plays a role in acute murine experimental autoimmune cystitis. 
  • Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. 
  • Angiotensin II promotes development of the renal microcirculation through AT1 receptors. 
  • Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. 
  • Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation. 
  • Angiotensin II stimulates canonical TGF-β signaling pathway through angiotensin type 1 receptor to induce granulation tissue contraction. 
  • Angiotensin II synergizes with BAFF to promote atheroprotective regulatory B cells. 
  • Angiotensin II type 1 receptor-associated protein is an endogenous inhibitor of angiotensin II type 1 receptor action in cardiac hypertrophy: role in check and balance. 
  • Angiotensin II type 1A receptors in vascular smooth muscle cells do not influence aortic remodeling in hypertension. 
  • Angiotensin II type 2 receptor mediates programmed cell death. 
  • Angiotensin II-induced MMP-2 activity and MMP-14 and basigin protein expression are mediated via the angiotensin II receptor type 1-mitogen-activated protein kinase 1 pathway in retinal pigment epithelium: implications for age-related macular degeneration. 
  • Angiotensin II-induced hypertension regulates AT1 receptor subtypes and extracellular matrix turnover in mouse retinal pigment epithelium. 
  • Angiotensin II: an immune costimulator? 
  • Angiotensin converting enzyme and genetic hypertension: cloning of rat cDNAs and characterization of the enzyme. 
  • Angiotensin induces the urinary peristaltic machinery during the perinatal period. 
  • Angiotensin receptor signaling and prostate tumor growth in mice. 
  • Angiotensin type 1A receptors in C1 neurons of the rostral ventrolateral medulla modulate the pressor response to aversive stress. 
  • Angiotensin type 2 receptor is expressed in murine atherosclerotic lesions and modulates lesion evolution. 
  • Angiotensin-converting enzyme 2 decreases formation and severity of angiotensin II-induced abdominal aortic aneurysms. 
  • Angiotensin-converting enzyme 2 deficiency in whole body or bone marrow-derived cells increases atherosclerosis in low-density lipoprotein receptor-/- mice. 
  • Angiotensin-converting enzyme 2 deficiency is associated with impaired gestational weight gain and fetal growth restriction. 
  • Angiotensin-converting enzyme 2 gene targeting studies in mice: mixed messages. 
  • Angiotensinogen gene null-mutant mice lack homeostatic regulation of glomerular filtration and tubular reabsorption. 
  • Animal model for maturity-onset diabetes of the young generated by disruption of the mouse glucokinase gene. 
  • Animal models for complement deficiencies. 
  • Animal models in the research of abdominal aortic aneurysms development. 
  • Animal models of bleeding and tissue repair. 
  • Animal models of depression in dopamine, serotonin, and norepinephrine transporter knockout mice: prominent effects of dopamine transporter deletions. 
  • Animal models of hereditary iron transport disorders. 
  • Animal models of steatohepatitis. 
  • Animal models of steatosis. 
  • Animal models provide insight into psychosomatic factors in diabetes. 
  • Animals lacking endothelin-converting enzyme-2 are deficient in learning and memory. 
  • Ank3-dependent SVZ niche assembly is required for the continued production of new neurons. 
  • Ankyrin-B coordinates the Na/K ATPase, Na/Ca exchanger, and InsP3 receptor in a cardiac T-tubule/SR microdomain. 
  • Ankyrin-B directs membrane tethering of periaxin and is required for maintenance of lens fiber cell hexagonal shape and mechanics. 
  • Ankyrin-B interactions with spectrin and dynactin-4 are required for dystrophin-based protection of skeletal muscle from exercise injury. 
  • Ankyrin-B is a PI3P effector that promotes polarized α5β1-integrin recycling via recruiting RabGAP1L to early endosomes. 
  • Ankyrin-B is required for coordinated expression of beta-2-spectrin, the Na/K-ATPase and the Na/Ca exchanger in the inner segment of rod photoreceptors. 
  • Ankyrin-B is required for intracellular sorting of structurally diverse Ca2+ homeostasis proteins. 
  • Ankyrin-B metabolic syndrome combines age-dependent adiposity with pancreatic β cell insufficiency. 
  • Ankyrin-B mutation causes type 4 long-QT cardiac arrhythmia and sudden cardiac death. 
  • Ankyrin-B syndrome: enhanced cardiac function balanced by risk of cardiac death and premature senescence. 
  • Ankyrin-B targets beta2-spectrin to an intracellular compartment in neonatal cardiomyocytes. 
  • Ankyrin-G Inhibits Endocytosis of Cadherin Dimers. 
  • Ankyrin-G and beta2-spectrin collaborate in biogenesis of lateral membrane of human bronchial epithelial cells. 
  • Ankyrin-G coordinates assembly of the spectrin-based membrane skeleton, voltage-gated sodium channels, and L1 CAMs at Purkinje neuron initial segments. 
  • Ankyrin-G coordinates intercalated disc signaling platform to regulate cardiac excitability in vivo. 
  • Ankyrin-G is a molecular partner of E-cadherin in epithelial cells and early embryos. 
  • Ankyrin-G promotes cyclic nucleotide-gated channel transport to rod photoreceptor sensory cilia. 
  • Ankyrin-based subcellular gradient of neurofascin, an immunoglobulin family protein, directs GABAergic innervation at purkinje axon initial segment. 
  • Ankyrin-rich membrane spanning protein as a novel modulator of transient receptor potential vanilloid 1-function in nociceptive neurons. 
  • AnkyrinG is required for clustering of voltage-gated Na channels at axon initial segments and for normal action potential firing. 
  • AnkyrinG is required to maintain axo-dendritic polarity in vivo. 
  • Ankyrins. 
  • Annexin 1 induced by anti-inflammatory drugs binds to NF-kappaB and inhibits its activation: anticancer effects in vitro and in vivo. 
  • Another cystic mystery solved. 
  • Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1beta. 
  • Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis. 
  • Antagonists of the system L neutral amino acid transporter (LAT) promote endothelial adhesivity of human red blood cells. 
  • Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. 
  • Anti-AIDS agents. 34. Synthesis and structure-activity relationships of betulin derivatives as anti-HIV agents. 
  • Anti-CD22 ligand-blocking antibody HB22.7 has independent lymphomacidal properties and augments the efficacy of 90Y-DOTA-peptide-Lym-1 in lymphoma xenografts. 
  • Anti-CD40 ligand monoclonal antibody delays the progression of murine autoimmune cholangitis. 
  • Anti-DNA and autoantibodies. 
  • Anti-DNA antibodies form immune deposits at distinct glomerular and vascular sites. 
  • Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation. 
  • Anti-EGFRvIII monoclonal antibody armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands. 
  • Anti-Ebola MAb 17A3 reacts with bovine and human alpha-2-macroglobulin proteins. 
  • Anti-GD2 antibody therapy for GD2-expressing tumors. 
  • Anti-La antibody production by MRL-1pr/1pr mice. Analysis of fine specificity. 
  • Anti-Sm autoantibodies in MRL mice: analysis of precursor frequency. 
  • Anti-TCR mAb induces peripheral tolerance to alloantigens and delays islet allograft rejection in autoimmune diabetic NOD mice. 
  • Anti-TCRβ mAb induces long-term allograft survival by reducing antigen-reactive T cells and sparing regulatory T cells. 
  • Anti-U1A monoclonal antibodies recognize unique epitope targets of U1A which are involved in the binding of U1 RNA. 
  • Anti-VEGF treatment-resistant pancreatic cancers secrete proinflammatory factors that contribute to malignant progression by inducing an EMT cell phenotype. 
  • Anti-amyloid therapy protects against retinal pigmented epithelium damage and vision loss in a model of age-related macular degeneration. 
  • Anti-amyloid-beta immunotherapy in Alzheimer's disease: relevance of transgenic mouse studies to clinical trials. 
  • Anti-angiogenesis effect of the novel anti-inflammatory and pro-resolving lipid mediators. 
  • Anti-angiogenic effects of interleukin-12 delivered by a novel hyperthermia induced gene construct. 
  • Anti-bombesin monoclonal antibodies modulate fetal mouse lung growth and maturation in utero and in organ cultures. 
  • Anti-glycoprotein D monoclonal antibody protects against herpes simplex virus type 1-induced diseases in mice functionally depleted of selected T-cell subsets or asialo GM1+ cells. 
  • Anti-idiotypic antibodies as vaccine candidates. The immune network. 
  • Anti-idiotypic monoclonal Ig specific for an anti-laminin Ig heavy chain transgene variable region. 
  • Anti-idiotypic monoclonal antibodies to GM1 identify ganglioside binding proteins. 
  • Anti-inflammatory activity of amine cyanoboranes, amine carboxyboranes, and related compounds. 
  • Anti-inflammatory and Anti-HIV Compounds from Swertia bimaculata. 
  • Anti-inflammatory and anti-osteoporotic activities of base-boronated nucleosides and phosphate-boronated nucleotides in rodents. 
  • Anti-inflammatory and vasoprotective activity of a retroviral-derived peptide, homologous to human endogenous retroviruses: endothelial cell effects. 
  • Anti-inflammatory effects of inhibiting the amine oxidase activity of semicarbazide-sensitive amine oxidase. 
  • Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia. 
  • Anti-intercellular adhesion molecule-1 antibody and intercellular adhesion molecule-1 gene deficiency do not prevent pulmonary neutrophil recruitment in polymicrobial sepsis. 
  • Anti-laminin reactivity and glomerular immune deposition by in vitro recombinant antibodies. 
  • Anti-mouse mesangial cell serum induces acute glomerulonephropathy in mice. 
  • Anti-receptor antibody-induced H-Y-specific delayed-type hypersensitivity responses in nonresponder mice. 
  • Anti-receptor antibody-induced suppression of murine H-Y-specific delayed-type hypersensitivity responses. 
  • Anti-tumor activity of a novel monoclonal antibody, NPC-1C, optimized for recognition of tumor antigen MUC5AC variant in preclinical models. 
  • Anti-tumor immunotherapy despite immunity to adenovirus using a novel adenoviral vector Ad5 [E1-, E2b-]-CEA. 
  • Antiadhesive properties of a quaternary structure-specific hybridoma antibody against type 1 fimbriae of Escherichia coli. 
  • Antiangiogenic action of redox-modulating Mn(III) meso-tetrakis(N-ethylpyridinium-2-yl)porphyrin, MnTE-2-PyP(5+), via suppression of oxidative stress in a mouse model of breast tumor. 
  • Antiangiogenic gene therapy targeting the endothelium-specific receptor tyrosine kinase Tie2. 
  • Antiangiogenic treatment with the three thrombospondin-1 type 1 repeats recombinant protein in an orthotopic human pancreatic cancer model. 
  • Antiangiogenic treatment with three thrombospondin-1 type 1 repeats versus gemcitabine in an orthotopic human pancreatic cancer model. 
  • Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut. 
  • Antibodies as specific renin inhibitors: studies with polyclonal and monoclonal antibodies and Fab fragments. 
  • Antibodies to Trichomonas vaginalis surface glycolipid. 
  • Antibodies to stem cell marker antigens reduce engraftment of hematopoietic stem cells. 
  • Antibody alone does not prevent experimental cytomegalovirus retinitis in mice with retrovirus-induced immunodeficiency (MAIDS). 
  • Antibody binding to a conformation-dependent epitope induces L-selectin association with the detergent-resistant cytoskeleton. 
  • Antibody formation and mannose-6-phosphate receptor expression impact the efficacy of muscle-specific transgene expression in murine Pompe disease. 
  • Antibody is critical for the clearance of murine norovirus infection. 
  • Antibody isotype-specific engagement of Fcgamma receptors regulates B lymphocyte depletion during CD20 immunotherapy. 
  • Antibody reacting with mouse mammary tumor virus in serum of breast carcinoma patients. 
  • Antibody response to a T-dependent antigen requires B cell expression of complement receptors. 
  • Antibody responses in athymic ('nude') mice implanted with neonatal or adult allogeneic thymus. 
  • Antibody-dependent cytolysis (ADCC) of tumor cells by activated murine macrophages is a two-step process: quantification of target binding and subsequent target lysis. 
  • Antibody-dependent lymphoid cell-mediated cytotoxicity: role of complement. 
  • Antibody-induced proteinase activation: a proposed mechanism for pemphigus. 
  • Antibody-mediated B-cell depletion before adoptive immunotherapy with T cells expressing CD20-specific chimeric T-cell receptors facilitates eradication of leukemia in immunocompetent mice. 
  • Antibody-mediated enzyme replacement therapy targeting both lysosomal and cytoplasmic glycogen in Pompe disease. 
  • Antibody-targeted photodynamic therapy. 
  • Anticancer therapeutic potential of Mn porphyrin/ascorbate system. 
  • Anticolon cancer activity of largazole, a marine-derived tunable histone deacetylase inhibitor. 
  • Antidote-mediated control of an anticoagulant aptamer in vivo. 
  • Antiepidermal growth factor variant III scFv fragment: effect of radioiodination method on tumor targeting and normal tissue clearance. 
  • Antifungal and cancer cell growth inhibitory activities of 1-(3',4',5'-trimethoxyphenyl)-2-nitro-ethylene. 
  • Antigen delivery by alpha(2)-macroglobulin enhances the cytotoxic T lymphocyte response. 
  • Antigen drives very low affinity B cells to become plasmacytes and enter germinal centers. 
  • Antigen processing in vivo and the elicitation of primary CTL responses. 
  • Antigen-binding repertoire and Ig H chain gene usage among B cell hybridomas from normal and autoimmune mice. 
  • Antigen-experienced CD4 T cells display a reduced capacity for clonal expansion in vivo that is imposed by factors present in the immune host. 
  • Antigen-presenting cell lines internalize peptide antigens via fluid-phase endocytosis. 
  • Antigen-presenting cells pulsed with unfractionated tumor-derived peptides are potent tumor vaccines. 
  • Antigen-specific induced Foxp3+ regulatory T cells are generated following CD40/CD154 blockade. 
  • Antigenic comparison of virus strains of mild and classical types of epidemic haemorrhagic fever isolated in China and adaptation of these to cultures of normal cells. 
  • Antigenicity and immunogenicity of a synthetic human immunodeficiency virus type 1 group m consensus envelope glycoprotein. 
  • Antigens of human pancreatic adenocarcinoma cells defined by murine monoclonal antibodies. 
  • Antigens shared by rat schwannomas, neuroblastomas, and a testicular interstitial cell carcinoma. 
  • Antihelminth compound niclosamide downregulates Wnt signaling and elicits antitumor responses in tumors with activating APC mutations. 
  • Antihyperlipidemic activity of amine cyanoboranes, amine carboxyboranes, and related compounds. 
  • Antiidiotypic antibody recognizes an amiloride binding domain within the alpha subunit of the epithelial Na+ channel. 
  • Antiinflammatory proteins associated with human and murine neoplasms. 
  • Antimicrobial activity of PLUNC protects against Pseudomonas aeruginosa infection. 
  • Antineoplastic activity of a series of boron analogues of alpha-amino acids. 
  • Antineoplastic activity of boron-containing thymidine nucleosides in Tmolt3 leukemic cells. 
  • Antineoplastic activity of tetrakis-mu-(trimethylamine-boranecarboxylato)-bis (trimethylamine-carboxyborane)dicopper (II) in Ehrlich ascites carcinoma. 
  • Antinuclear antibodies and nuclear antigens in NZB myeloma ascitic fluids. 
  • Antioxidants suppress mortality in the female NZB x NZW F1 mouse model of systemic lupus erythematosus (SLE). 
  • Antiproliferative effects of cyclocreatine on human prostatic carcinoma cells. 
  • Antiproliferative effects of interferon alpha on hepatic progenitor cells in vitro and in vivo. 
  • Antiretroviral restriction factors in mice. 
  • Antiseizure effects of TrkB kinase inhibition. 
  • Antisense inhibition of P-glycoprotein expression using peptide-oligonucleotide conjugates. 
  • Antitenascin antibody 81C6 armed with 177Lu: in vivo comparison of macrocyclic and acyclic ligands. 
  • Antitumor activity of a monoclonal antibody directed against gastrin-releasing peptide in patients with small cell lung cancer. 
  • Antitumor activity of temozolomide combined with irinotecan is partly independent of O6-methylguanine-DNA methyltransferase and mismatch repair phenotypes in xenograft models. 
  • Antitumor and Antiangiogenic Effects of Aspirin-PC in Ovarian Cancer. 
  • Antitumor immunity can be uncoupled from autoimmunity following heat shock protein 70-mediated inflammatory killing of normal pancreas. 
  • Antitumorigenesis of antioxidants in a transgenic Rac1 model of Kaposi's sarcoma. 
  • Antitumour activity of S-p-bromobenzylglutathione cyclopentyl diester in vitro and in vivo. Inhibition of glyoxalase I and induction of apoptosis. 
  • Antitussive effect of Asparagus racemosus root against sulfur dioxide-induced cough in mice. 
  • Antitussive potential of methanol extract of stem bark of Ficus racemosa Linn. 
  • Antiviral Effects of ABMA against Herpes Simplex Virus Type 2 In Vitro and In Vivo. 
  • Antiviral activity of mixed-valence rare earth borotungstate heteropoly blues against influenza virus in mice. 
  • Anxiety Associated Increased CpG Methylation in the Promoter of Asb1: A Translational Approach Evidenced by Epidemiological and Clinical Studies and a Murine Model. 
  • Anxiety-like behaviors in mice lacking GIT2. 
  • Anxiolytic effects of acute morphine can be modulated by nitric oxide systems. 
  • Apo E structure determines VLDL clearance and atherosclerosis risk in mice. 
  • ApoA-I induced CD31 in bone marrow-derived vascular progenitor cells increases adhesion: implications for vascular repair. 
  • ApoB-48 and apoB-100 differentially influence the expression of type-III hyperlipoproteinemia in APOE*2 mice. 
  • ApoE isoform affects LTP in human targeted replacement mice. 
  • ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42. 
  • ApoE, Alzheimer's disease, and recovery from brain stress. 
  • ApoE4 markedly exacerbates tau-mediated neurodegeneration in a mouse model of tauopathy. 
  • ApoER2 function in the establishment and maintenance of retinal synaptic connectivity. 
  • Apolipoprotein E COG 133 mimetic peptide improves 5-fluorouracil-induced intestinal mucositis. 
  • Apolipoprotein E Exerts a Whole-Brain Protective Property by Promoting M1? Microglia Quiescence After Experimental Subarachnoid Hemorrhage in Mice. 
  • Apolipoprotein E Mimetic Peptide Increases Cerebral Glucose Uptake by Reducing Blood-Brain Barrier Disruption after Controlled Cortical Impact in Mice: An 18F-Fluorodeoxyglucose PET/CT Study. 
  • Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport. 
  • Apolipoprotein E affects the central nervous system response to injury and the development of cerebral edema. 
  • Apolipoprotein E allele-dependent pathogenesis: a model for age-related retinal degeneration. 
  • Apolipoprotein E and Reelin ligands modulate tau phosphorylation through an apolipoprotein E receptor/disabled-1/glycogen synthase kinase-3beta cascade. 
  • Apolipoprotein E and mimetic peptide initiate a calcium-dependent signaling response in macrophages. 
  • Apolipoprotein E and peptide mimetics modulate inflammation by binding the SET protein and activating protein phosphatase 2A. 
  • Apolipoprotein E and the CNS response to injury. 
  • Apolipoprotein E deficiency worsens outcome from global cerebral ischemia in the mouse. 
  • Apolipoprotein E expression and behavioral toxicity of high charge, high energy (HZE) particle radiation. 
  • Apolipoprotein E in neurology. 
  • Apolipoprotein E isoform mediated regulation of nitric oxide release. 
  • Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice. 
  • Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain. 
  • Apolipoprotein E knock-out and knock-in mice: atherosclerosis, metabolic syndrome, and beyond. 
  • Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex. 
  • Apolipoprotein E modifies the CNS response to injury via a histamine-mediated pathway. 
  • Apolipoprotein E modulates glial activation and the endogenous central nervous system inflammatory response. 
  • Apolipoprotein E plays a key role against cryptosporidial infection in transgenic undernourished mice. 
  • Apolipoprotein E suppresses glial cell secretion of TNF alpha. 
  • Apolipoprotein E-Mimetic COG1410 Reduces Acute Vasogenic Edema following Traumatic Brain Injury. 
  • Apolipoprotein E-deficient mice created by systemic administration of antisense oligodeoxynucleotides: a new model for lipoprotein metabolism studies. 
  • Apolipoprotein E-deficient mice have increased susceptibility to focal cerebral ischemia. 
  • Apolipoprotein E-derived peptides ameliorate clinical disability and inflammatory infiltrates into the spinal cord in a murine model of multiple sclerosis. 
  • Apolipoprotein E-genotype dependent hippocampal and cortical responses to traumatic brain injury. 
  • Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner. 
  • Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes. 
  • Apolipoprotein E4 exaggerates diabetic dyslipidemia and atherosclerosis in mice lacking the LDL receptor. 
  • Apolipoprotein J/clusterin induction in myocarditis: A localized response gene to myocardial injury. 
  • ApolipoproteinE mimetic peptides improve outcome after focal ischemia. 
  • Apolipoproteins and apolipoprotein mimetic peptides modulate phagocyte trafficking through chemotactic activity. 
  • Apoptosis and B cell tolerance. 
  • Apoptosis rate can be accelerated or decelerated by overexpression or reduction of the level of elongation factor-1 alpha. 
  • Apoptosis: final common pathway of photoreceptor death in rd, rds, and rhodopsin mutant mice. 
  • Apoptotic Debris Accumulates on Hematopoietic Cells and Promotes Disease in Murine and Human Systemic Lupus Erythematosus. 
  • Apoptotic Diminution of Immature Single and Double Positive Thymocyte Subpopulations Contributes to Thymus Involution During Murine Polymicrobial Sepsis. 
  • Apoptotic cells activate the "phoenix rising" pathway to promote wound healing and tissue regeneration. 
  • Apparent elastic modulus and hysteresis of skeletal muscle cells throughout differentiation. 
  • Application of a Novel Murine Ear Vein Model to Evaluate the Effects of a Vascular Radioprotectant on Radiation-Induced Vascular Permeability and Leukocyte Adhesion. 
  • Application of chemoproteomics to drug discovery: identification of a clinical candidate targeting hsp90. 
  • Application of combined omics platforms to accelerate biomedical discovery in diabesity. 
  • Application of microdialysis and voltammetry to assess dopamine functions in genetically altered mice: correlation with locomotor activity. 
  • Application of proteomic marker ensembles to subcellular organelle identification. 
  • Application of single-cell RNA sequencing in optimizing a combinatorial therapeutic strategy in metastatic renal cell carcinoma. 
  • Applications for green fluorescent protein (GFP) in the study of host-pathogen interactions. 
  • Applications of gene fusions to green fluorescent protein and flow cytometry to the study of bacterial gene expression in host cells. 
  • Applying technologies towards safe and effective medicines. 
  • Approximating transcranial magnetic stimulation with electric stimulation in mouse: a simulation study. 
  • Aptamers selected against the unglycosylated EGFRvIII ectodomain and delivered intracellularly reduce membrane-bound EGFRvIII and induce apoptosis. 
  • Aquaporin 6 binds calmodulin in a calcium-dependent manner. 
  • Aquaporin 9 is the major pathway for glycerol uptake by mouse erythrocytes, with implications for malarial virulence. 
  • Aquaporin in Candida: characterization of a functional water channel protein. 
  • Arachidonic acid activates Kir2.3 channels by enhancing channel-phosphatidyl-inositol 4,5-bisphosphate interactions. 
  • Are there effective new strategies for the treatment of acute and chronic GvHD? 
  • Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. 
  • Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. 
  • Arhgap24 inactivates Rac1 in mouse podocytes, and a mutant form is associated with familial focal segmental glomerulosclerosis. 
  • Aromatic hydrocarbon receptor interaction with the retinoblastoma protein potentiates repression of E2F-dependent transcription and cell cycle arrest. 
  • Aromatic hydrocarbon receptor polymorphism: development of new methods to correlate genotype with phenotype. 
  • Arrestin translocation is induced at a critical threshold of visual signaling and is superstoichiometric to bleached rhodopsin. 
  • Arsenite transport by mammalian aquaglyceroporins AQP7 and AQP9. 
  • Arterial response to shear stress critically depends on endothelial TRPV4 expression. 
  • Arthritis syndromes associated with human T cell lymphotropic virus type I infection. 
  • Aryl hydrocarbon receptor activation in genital tubercle, palate, and other embryonic tissues in 2,3,7, 8-tetrachlorodibenzo-p-dioxin-responsive lacZ mice. 
  • Aryl hydrocarbon receptor deficiency causes dysregulated cellular matrix metabolism and age-related macular degeneration-like pathology. 
  • Ascites Increases Expression/Function of Multidrug Resistance Proteins in Ovarian Cancer Cells. 
  • Aspartyl-(asparaginyl)-beta-hydroxylase regulates hepatocellular carcinoma invasiveness. 
  • Aspergillus fumigatus calcipressin CbpA is involved in hyphal growth and calcium homeostasis. 
  • Aspirin inhibits tumor necrosis factoralpha gene expression in murine tissue macrophages. 
  • Aspirin-triggered resolvin D1 prevents surgery-induced cognitive decline. 
  • Assembling OX40 aptamers on a molecular scaffold to create a receptor-activating aptamer. 
  • Assembling the pieces. 
  • Assembly of signaling complexes by the sodium-hydrogen exchanger regulatory factor family of PDZ-containing proteins. 
  • Assembly of the dystrophin-associated protein complex does not require the dystrophin COOH-terminal domain. 
  • Assessing a role for enhancer-blocking activity in gene regulation within the murine T-cell receptor alpha/delta locus. 
  • Assessing cardiac injury in mice with dual energy-microCT, 4D-microCT, and microSPECT imaging after partial heart irradiation. 
  • Assessing overall risk in reproductive experiments. 
  • Assessing some dynamic properties of the living nervous system. 
  • Assessment of diabetic nephropathy in the Akita mouse. 
  • Assessment of myeloma maintenance regimen of prednisone. Adriamycin, imuran, and vincristine in a murine plasmacytoma model. 
  • Assessment of photosensitizer dosimetry and tissue damage assay for photodynamic therapy in advanced-stage tumors. 
  • Assignment of a single disulphide bridge in human alpha2-antiplasmin: implications for the structural and functional properties. 
  • Assignment of human gamma crystallin multigene family to chromosome 2. 
  • Assignment of the agent of Tyzzer's disease to Clostridium piliforme comb. nov. on the basis of 16S rRNA sequence analysis. 
  • Assignment of the beta-subunit of rod photoreceptor cGMP phosphodiesterase gene PDEB (homolog of the mouse rd gene) to human chromosome 4p16. 
  • Assignment of the creatine transporter gene (SLC6A8) to human chromosome Xq28 telomeric to G6PD. 
  • Assignment of the gene for myelin proteolipid protein to the X chromosome: implications for X-linked myelin disorders. 
  • Assignment of the zeta-crystallin gene (CRYZ) to human chromosome 1p22-p31 and identification of restriction fragment length polymorphisms. 
  • Association between the 7 S RNA and the lupus La protein varies among cell types. 
  • Association of age-dependent liver injury and fibrosis with immune cell populations. 
  • Association of heat production with 18F-FDG accumulation in murine brown adipose tissue after stress. 
  • Association of low-frequency and rare coding-sequence variants with blood lipids and coronary heart disease in 56,000 whites and blacks. 
  • Association of myosin light chain kinase with lymphocyte membrane-cytoskeleton complex. 
  • Association of protein kinase C(lambda) with adducin in 3T3-L1 adipocytes. 
  • Association of the T-cell regulatory gene CTLA4 with susceptibility to autoimmune disease. 
  • Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction. 
  • Association of the kinesin-binding domain of RanBP2 to KIF5B and KIF5C determines mitochondria localization and function. 
  • Association of the protein kinases c-Bcr and Bcr-Abl with proteins of the 14-3-3 family. 
  • Association of whirlin with Cav1.3 (alpha1D) channels in photoreceptors, defining a novel member of the usher protein network. 
  • Associations of neighborhood concentrated poverty, neighborhood racial/ethnic composition, and indoor allergen exposures: a cross-sectional analysis of los angeles households, 2006-2008. 
  • Astatination of proteins using an N-succinimidyl tri-n-butylstannyl benzoate intermediate. 
  • Astatine-211 labeled anti-HER2 5F7 single domain antibody fragment conjugates: radiolabeling and preliminary evaluation. 
  • Astatine-211 labeling of internalizing anti-EGFRvIII monoclonal antibody using N-succinimidyl 5-[211At]astato-3-pyridinecarboxylate. 
  • Astatine-211-labeled biotin conjugates resistant to biotinidase for use in pretargeted radioimmunotherapy. 
  • Astringency: a more stringent definition. 
  • Astrocyte cytolysis by MHC class II-specific mouse T cell clones. 
  • Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. 
  • Astrocytes Assemble Thalamocortical Synapses by Bridging NRX1α and NL1 via Hevin. 
  • Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development. 
  • Astrocytes refine cortical connectivity at dendritic spines. 
  • Astrocytic CX43 hemichannels and gap junctions play a crucial role in development of chronic neuropathic pain following spinal cord injury. 
  • Astrocytic neuroligins control astrocyte morphogenesis and synaptogenesis. 
  • Astroglia induce cytotoxic effects on brain tumors via a nitric oxide-dependent pathway both in vitro and in vivo. 
  • Asymmetric cell divisions promote stratification and differentiation of mammalian skin. 
  • Asynchronous synapse elimination in neonatal motor units: studies using GFP transgenic mice. 
  • Ataxia telangiectasia mutant protein activates c-Abl tyrosine kinase in response to ionizing radiation. 
  • Ataxia telangiectasia-mutated and p53 are potential mediators of chloroquine-induced resistance to mammary carcinogenesis. 
  • Atm deficiency affects both apoptosis and proliferation to augment Myc-induced lymphomagenesis. 
  • Atm deletion with dual recombinase technology preferentially radiosensitizes tumor endothelium. 
  • Atomic description of the immune complex involved in heparin-induced thrombocytopenia. 
  • Attenuated hepatic inflammation and fibrosis in angiotensin type 1a receptor deficient mice. 
  • Attenuated host resistance against Mycobacterium bovis BCG infection in mice lacking osteopontin. 
  • Attenuated virulence of a Francisella mutant lacking the lipid A 4'-phosphatase. 
  • Attenuation of acid induced oesophagitis in VR-1 deficient mice. 
  • Attenuation of cerebral vasospasm after subarachnoid hemorrhage in mice overexpressing extracellular superoxide dismutase. 
  • Attenuation of herpes simplex virus neurovirulence with picornavirus cis-acting genetic elements. 
  • Attenuation of store-operated Ca2+ current impairs salivary gland fluid secretion in TRPC1(-/-) mice. 
  • Attenuation of the effects of punishment by ethanol: comparisons with chlordiazepoxide. 
  • Attenuation of the retinoblastoma pathway in pancreatic neuroendocrine tumors due to increased cdk4/cdk6. 
  • Atypical antipsychotics clozapine and quetiapine attenuate prepulse inhibition deficits in dopamine transporter knockout mice. 
  • Augmentation of cardiac contractility mediated by the human beta(3)-adrenergic receptor overexpressed in the hearts of transgenic mice. 
  • Augmentation of syngeneic tumor-specific immunity by semiallogeneic cell hybrids. 
  • Augmentation of transvascular transport of macromolecules and nanoparticles in tumors using vascular endothelial growth factor. 
  • Augmented Responses to Ozone in Obese Mice Require IL-17A and Gastrin-Releasing Peptide. 
  • Augmenting podocyte injury promotes advanced diabetic kidney disease in Akita mice. 
  • Aurora-A phosphorylates, activates, and relocalizes the small GTPase RalA. 
  • Autism-associated CHD8 deficiency impairs axon development and migration of cortical neurons. 
  • Autistic-like behaviour and cerebellar dysfunction in Purkinje cell Tsc1 mutant mice. 
  • Autoantibodies against cell surface GRP78 promote tumor growth in a murine model of melanoma. 
  • Autoantibodies and their idiotypes. 
  • Autocrine BDNF-TrkB signalling within a single dendritic spine. 
  • Autocrine Complement Inhibits IL10-Dependent T-cell-Mediated Antitumor Immunity to Promote Tumor Progression. 
  • Autocrine phosphorylation of p70(S6k) in response to acute stretch in myotubes. 
  • Autocrine prolactin induced by the Pten-Akt pathway is required for lactation initiation and provides a direct link between the Akt and Stat5 pathways. 
  • Autocrine stimulation of mas oncogene leads to altered growth control. 
  • Autofeedback suppression of growth hormone (GH) secretion in transgenic mice expressing a human GH reporter targeted by tyrosine hydroxylase 5'-flanking sequences to the hypothalamus. 
  • Autoimmune dacryoadenitis of NOD/LtJ mice and its subsequent effects on tear protein composition. 
  • Autoimmune hepatitis. 
  • Autoimmunity in dry eye is due to resistance of Th17 to Treg suppression. 
  • Autoimmunity: the nuclear arsenal of autoimmunity. 
  • Autologous fixed tumor vaccine: a formulation with cytokine-microparticles for protective immunity against recurrence of human hepatocellular carcinoma. 
  • Autologous stem cell transplantation for autoimmune diseases: issues in protocol development. 
  • Automated design of ligands to polypharmacological profiles. 
  • Automated feedback control of body temperature for small animal studies with MR microscopy. 
  • Automated segmentation of mouse brain images using extended MRF. 
  • Automated segmentation of neuroanatomical structures in multispectral MR microscopy of the mouse brain. 
  • Automated segmentation of the actively stained mouse brain using multi-spectral MR microscopy. 
  • Autonomic nerve development contributes to prostate cancer progression. 
  • Autophagic activity dictates the cellular response to oncogenic RAS. 
  • Autophagy Genes Enhance Murine Gammaherpesvirus 68 Reactivation from Latency by Preventing Virus-Induced Systemic Inflammation. 
  • Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. 
  • Autophagy is a defense mechanism inhibiting BCG and Mycobacterium tuberculosis survival in infected macrophages. 
  • Autophagy is essential for mitochondrial clearance in mature T lymphocytes. 
  • Autophagy is redundant for the host defense against systemic Candida albicans infections. 
  • Autophagy links inflammasomes to atherosclerotic progression. 
  • Autophagy provides nutrients but can lead to Chop-dependent induction of Bim to sensitize growth factor-deprived cells to apoptosis. 
  • Autophagy regulates T lymphocyte proliferation through selective degradation of the cell-cycle inhibitor CDKN1B/p27Kip1. 
  • Autophagy regulates endoplasmic reticulum homeostasis and calcium mobilization in T lymphocytes. 
  • Autophagy-dependent metabolic reprogramming sensitizes TSC2-deficient cells to the antimetabolite 6-aminonicotinamide. 
  • Autophosphorylation in the leucine-rich repeat kinase 2 (LRRK2) GTPase domain modifies kinase and GTP-binding activities. 
  • Autophosphorylation of CaMKK2 generates autonomous activity that is disrupted by a T85S mutation linked to anxiety and bipolar disorder. 
  • Autoradiographic analysis of nuclear estrogen binding sites during postnatal development of the genital tract of female mice. 
  • Autoreactivity in an HIV-1 broadly reactive neutralizing antibody variable region heavy chain induces immunologic tolerance. 
  • Autoreceptor presynaptic control of dopamine release from striatum is lost at early stages of manganese poisoning. 
  • Autosomal-dominant hemochromatosis is associated with a mutation in the ferroportin (SLC11A3) gene. 
  • Autotaxin, an ectoenzyme that produces lysophosphatidic acid, promotes the entry of lymphocytes into secondary lymphoid organs. 
  • Axin gene methylation status correlates with radiosensitivity of lung cancer cells. 
  • Axin2 regulates chondrocyte maturation and axial skeletal development. 
  • Axonal neurofilaments control multiple fiber properties but do not influence structure or spacing of nodes of Ranvier. 
  • Axonal regrowth after spinal cord injury via chondroitinase and the tissue plasminogen activator (tPA)/plasmin system. 
  • Axotomized mouse retinal ganglion cells containing melanopsin show enhanced survival, but not enhanced axon regrowth into a peripheral nerve graft. 
  • B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse. 
  • B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation. 
  • B cell antigen receptor endocytosis and antigen presentation to T cells require Vav and dynamin. 
  • B cell depletion delays collagen-induced arthritis in mice: arthritis induction requires synergy between humoral and cell-mediated immunity. 
  • B cell depletion reduces the development of atherosclerosis in mice. 
  • B cell maintenance of subcapsular sinus macrophages protects against a fatal viral infection independent of adaptive immunity. 
  • B cell, T cell and monocyte origin of the guinea pig L2C leukemia, mouse lymphomas and human leukemias and lymphoblastic cell lines. 
  • B cell-directed therapies for autoimmune disease and correlates of disease response and relapse. 
  • B cells are required for optimal CD4+ and CD8+ T cell tumor immunity: therapeutic B cell depletion enhances B16 melanoma growth in mice. 
  • B cells contribute to ischemia/reperfusion-mediated tissue injury. 
  • B cells in chronic graft-versus-host disease. 
  • B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies. 
  • B lymphocyte depletion by CD20 monoclonal antibody prevents diabetes in nonobese diabetic mice despite isotype-specific differences in Fc gamma R effector functions. 
  • B lymphocytes differentially influence acute and chronic allograft rejection in mice. 
  • B lymphocytes trigger monocyte mobilization and impair heart function after acute myocardial infarction. 
  • B lymphocytes: how they develop and function. 
  • B-1a and B-1b cells exhibit distinct developmental requirements and have unique functional roles in innate and adaptive immunity to S. pneumoniae. 
  • B-Cell Depletion Reduces the Maturation of Cerebral Cavernous Malformations in Murine Models. 
  • B-cell depletion in vitro and in vivo with an afucosylated anti-CD19 antibody. 
  • B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals. 
  • B-cell maturation antigen is a promising target for adoptive T-cell therapy of multiple myeloma. 
  • B-cell targeting in chronic graft-versus-host disease. 
  • B-lymphocyte contributions to human autoimmune disease. 
  • B-lymphocyte depletion ameliorates Sjögren's syndrome in Id3 knockout mice. 
  • B-lymphocyte depletion reduces skin fibrosis and autoimmunity in the tight-skin mouse model for systemic sclerosis. 
  • B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB. 
  • B10 cell regulation of health and disease. 
  • B10 cells and regulatory B cells balance immune responses during inflammation, autoimmunity, and cancer. 
  • BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors. 
  • BAG3 (Bcl-2-Associated Athanogene-3) Coding Variant in Mice Determines Susceptibility to Ischemic Limb Muscle Myopathy by Directing Autophagy. 
  • BATF Modulates the Th2 Locus Control Region and Regulates CD4+ T Cell Fate during Antihelminth Immunity. 
  • BAX-mediated cell death affects early germ cell loss and incidence of testicular teratomas in Dnd1(Ter/Ter) mice. 
  • BBS4 regulates the expression and secretion of FSTL1, a protein that participates in ciliogenesis and the differentiation of 3T3-L1. 
  • BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization. 
  • BCL2 interaction with actin in vitro may inhibit cell motility by enhancing actin polymerization. 
  • BCR and Endosomal TLR Signals Synergize to Increase AID Expression and Establish Central B Cell Tolerance. 
  • BDNF profoundly and specifically increases KCNQ4 expression in neurons derived from embryonic stem cells. 
  • BDNF-mediated cerebellar granule cell development is impaired in mice null for CaMKK2 or CaMKIV. 
  • BIN1 is reduced and Cav1.2 trafficking is impaired in human failing cardiomyocytes. 
  • BLyS and APRIL in rheumatoid arthritis. 
  • BMP antagonism by Noggin is required in presumptive notochord cells for mammalian foregut morphogenesis. 
  • BMP antagonism is required in both the node and lateral plate mesoderm for mammalian left-right axis establishment. 
  • BMP antagonism protects Nodal signaling in the gastrula to promote the tissue interactions underlying mammalian forebrain and craniofacial patterning. 
  • BMP ligands act redundantly to pattern the dorsal telencephalic midline. 
  • BMP receptor IA is required in mammalian neural crest cells for development of the cardiac outflow tract and ventricular myocardium. 
  • BMP receptor IA is required in the mammalian embryo for endodermal morphogenesis and ectodermal patterning. 
  • BMP signaling and cellular dynamics during regeneration of airway epithelium from basal progenitors. 
  • BMP signaling in the development of the mouse esophagus and forestomach. 
  • BMP signaling in the epiblast is required for proper recruitment of the prospective paraxial mesoderm and development of the somites. 
  • BMP2, but not BMP4, is crucial for chondrocyte proliferation and maturation during endochondral bone development. 
  • BMP4 is essential for lens induction in the mouse embryo. 
  • BMS-229724 is a tight-binding inhibitor of cytosolic phospholipase A2 that acts at the lipid/water interface and possesses anti-inflammatory activity in skin inflammation models. 
  • BMS-345541 is a highly selective inhibitor of I kappa B kinase that binds at an allosteric site of the enzyme and blocks NF-kappa B-dependent transcription in mice. 
  • BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. 
  • BRAF Inhibition Stimulates Melanoma-Associated Macrophages to Drive Tumor Growth. 
  • BRCA1 is required for common-fragile-site stability via its G2/M checkpoint function. 
  • BRCA2 monoclonal antibodies react with differentiating epithelium. 
  • BRG1 and BRM SWI/SNF ATPases redundantly maintain cardiomyocyte homeostasis by regulating cardiomyocyte mitophagy and mitochondrial dynamics in vivo. 
  • BSTA promotes mTORC2-mediated phosphorylation of Akt1 to suppress expression of FoxC2 and stimulate adipocyte differentiation. 
  • BW2258U89: a GRP receptor antagonist which inhibits small cell lung cancer growth. 
  • Bacteria-host cell interaction mediated by cellular cholesterol/glycolipid-enriched microdomains. 
  • Bacterial DNA induces murine interferon-gamma production by stimulation of interleukin-12 and tumor necrosis factor-alpha. 
  • Bacterial genetics by flow cytometry: rapid isolation of Salmonella typhimurium acid-inducible promoters by differential fluorescence induction. 
  • Bacterial lipopolysaccharide induces uncoupling protein-2 expression in hepatocytes by a tumor necrosis factor-alpha-dependent mechanism. 
  • Bacterial lipopolysaccharides and mycoplasmal lipoglycans: a comparison between their abilities to induce macrophage-mediated tumor cell killing and Limulus amebocyte lysate clotting. 
  • Bacterial penetration of bladder epithelium through lipid rafts. 
  • Bacterial-mucosal interactions in inflammatory bowel disease: an alliance gone bad. 
  • Balance of Irgm protein activities determines IFN-gamma-induced host defense. 
  • Balancing the bipotential gonad between alternative organ fates: a new perspective on an old problem. 
  • Bartonella henselae: etiology of pulmonary nodules in a patient with depressed cell-mediated immunity. 
  • Basal B cell receptor-directed phosphatidylinositol 3-kinase signaling turns off RAGs and promotes B cell-positive selection. 
  • Basal and stimulated protein S-nitrosylation in multiple cell types and tissues. 
  • Basal cell adhesion molecule/lutheran protein. The receptor critical for sickle cell adhesion to laminin. 
  • Basal cells are a multipotent progenitor capable of renewing the bronchial epithelium. 
  • Basal cells as stem cells of the mouse trachea and human airway epithelium. 
  • Basal ganglia outputs map instantaneous position coordinates during behavior. 
  • Basal laminar deposit formation in APO B100 transgenic mice: complex interactions between dietary fat, blue light, and vitamin E. 
  • Base mutations in the terminal noncoding regions of the genome of vesicular stomatitis virus isolated from persistent infections of L cells. 
  • Basement membranes. 
  • Basic fibroblast growth factor downregulates Bcl-2 and promotes apoptosis in MCF-7 human breast cancer cells. 
  • BayFish: Bayesian inference of transcription dynamics from population snapshots of single-molecule RNA FISH in single cells. 
  • Bayesian analysis of signaling networks governing embryonic stem cell fate decisions. 
  • Bayesian inferences on umbrella orderings. 
  • Bayesian latent variable models for mixed discrete outcomes. 
  • Bayesian models for multivariate current status data with informative censoring. 
  • Bazedoxifene exhibits antiestrogenic activity in animal models of tamoxifen-resistant breast cancer: implications for treatment of advanced disease. 
  • Bbeta-adrenergic receptor kinase-1 levels in catecholamine-induced myocardial hypertrophy: regulation by beta- but not alpha1-adrenergic stimulation. 
  • Bcl-2 accelerates multistep prostate carcinogenesis in vivo. 
  • Bcl-xL is an oncogenic driver in colorectal cancer. 
  • Bcr-Abl kinase modulates the translation regulators ribosomal protein S6 and 4E-BP1 in chronic myelogenous leukemia cells via the mammalian target of rapamycin. 
  • Bcr-Abl-mediated protection from apoptosis downstream of mitochondrial cytochrome c release. 
  • Beat frequency is bimodally distributed in spermatozoa from T/t12 mice. 
  • Behavioral activation by enkephalins in mice. 
  • Behavioral and neurochemical changes in folate-deficient mice. 
  • Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. 
  • Behavioral characterization of P311 knockout mice. 
  • Behavioral disturbances in adult mice following neonatal virus infection or kynurenine treatment--role of brain kynurenic acid. 
  • Behavioral manipulation of the diabetic phenotype in ob/ob mice. 
  • Behavioral phenotyping of transgenic and knockout animals: a cautionary tale. 
  • Behavioral responses to social stress in noradrenaline transporter knockout mice: effects on social behavior and depression. 
  • Behavioural and cardiovascular effects of disrupting the angiotensin II type-2 receptor in mice. 
  • Being there: cellular targeting of voltage-gated sodium channels in the heart. 
  • Beneficial effects of cholecystokinin-receptor blockade and inhibition of proteolytic enzyme activity in experimental acute hemorrhagic pancreatitis in mice. Evidence for cholecystokinin as a major factor in the development of acute pancreatitis. 
  • Beneficial effects of the Rho kinase inhibitor Y27632 in murine puromycin aminonucleoside nephrosis. 
  • Beryllium fluoride-induced cell proliferation: a process requiring P21(ras)-dependent activated signal transduction and NF-kappaB-dependent gene regulation. 
  • Beta-adrenergic axis and heart disease. 
  • Beta-adrenergic regulation of cholecystokinin secretion in STC-1 cells. 
  • Beta-agonist- and prostaglandin E1-induced translocation of the beta-adrenergic receptor kinase: evidence that the kinase may act on multiple adenylate cyclase-coupled receptors. 
  • Beta-arrestin 2 mediates endocytosis of type III TGF-beta receptor and down-regulation of its signaling. 
  • Beta-arrestin 2: a receptor-regulated MAPK scaffold for the activation of JNK3. 
  • Beta-arrestin and Mdm2 mediate IGF-1 receptor-stimulated ERK activation and cell cycle progression. 
  • Beta-arrestin- and G protein receptor kinase-mediated calcium-sensing receptor desensitization. 
  • Beta-arrestin- but not G protein-mediated signaling by the "decoy" receptor CXCR7. 
  • Beta-arrestin-2 regulates the development of allergic asthma. 
  • Beta-arrestin-mediated beta1-adrenergic receptor transactivation of the EGFR confers cardioprotection. 
  • Beta-arrestin-mediated localization of smoothened to the primary cilium. 
  • Beta-arrestin-mediated signaling regulates protein synthesis. 
  • Beta-arrestin1 mediates insulin-like growth factor 1 (IGF-1) activation of phosphatidylinositol 3-kinase (PI3K) and anti-apoptosis. 
  • Beta-arrestin2-mediated inotropic effects of the angiotensin II type 1A receptor in isolated cardiac myocytes. 
  • Beta-arrestins regulate atherosclerosis and neointimal hyperplasia by controlling smooth muscle cell proliferation and migration. 
  • Beta-arrestins specifically constrain beta2-adrenergic receptor signaling and function in airway smooth muscle. 
  • Beta-blockers alprenolol and carvedilol stimulate beta-arrestin-mediated EGFR transactivation. 
  • Beta-catenin and transforming growth factor beta have distinct roles regulating fibroblast cell motility and the induction of collagen lattice contraction. 
  • Beta-catenin is a mediator of the response of fibroblasts to irradiation. 
  • Beta-catenin regulates wound size and mediates the effect of TGF-beta in cutaneous healing. 
  • Beta-catenin signaling pathway is crucial for bone morphogenetic protein 2 to induce new bone formation. 
  • Beta-catenin signaling plays a disparate role in different phases of fracture repair: implications for therapy to improve bone healing. 
  • Beta1-adrenergic receptors maintain fetal heart rate and survival. 
  • Beta1-adrenergic receptors stimulate cardiac contractility and CaMKII activation in vivo and enhance cardiac dysfunction following myocardial infarction. 
  • Beta2 adrenergic receptor activation stimulates pro-inflammatory cytokine production in macrophages via PKA- and NF-kappaB-independent mechanisms. 
  • Beta2-adrenergic receptor overexpression in the developing mouse heart: evidence for targeted modulation of ion channels. 
  • Bevacizumab and rapamycin induce growth suppression in mouse models of hepatocellular carcinoma. 
  • Bevacizumab-induced alterations in vascular permeability and drug delivery: a novel approach to augment regional chemotherapy for in-transit melanoma. 
  • Beyond Oncolytics: E1B55K-Deleted Adenovirus as a Vaccine Delivery Vector. 
  • Bi-ligand surfaces with oriented and patterned protein for real-time tracking of cell migration. 
  • Biallelic mutations in FDXR cause neurodegeneration associated with inflammation. 
  • Bicarbonate alters cellular responses in respiration assays. 
  • Bidirectional modulation of substantia nigra activity by motivational state. 
  • Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. 
  • Biliary excretion of glycolipid in induced or inherited glucosylceramide lipidosis. 
  • Bimodal quantitative relationships between histone modifications for X-linked and autosomal loci. 
  • Binding and endocytosis of alpha 2-macroglobulin-plasmin complexes. 
  • Binding kinetics of superantigen with TCR and MHC class II. 
  • Binding of rat alpha 1-inhibitor-3-methylamine to the alpha 2-macroglobulin signaling receptor induces second messengers. 
  • Binding of receptor-recognized forms of alpha2-macroglobulin to the alpha2-macroglobulin signaling receptor activates phosphatidylinositol 3-kinase. 
  • Binding of rituximab, trastuzumab, cetuximab, or mAb T101 to cancer cells promotes trogocytosis mediated by THP-1 cells and monocytes. 
  • Binding of tenascin-C to soluble fibronectin and matrix fibrils. 
  • Binding specificity of a monoclonal anti-DNA antibody. 
  • Binocular deprivation induces both age-dependent and age-independent forms of plasticity in parvalbumin inhibitory neuron visual response properties. 
  • Bioactivation of nitroglycerin by the mitochondrial aldehyde dehydrogenase. 
  • Bioavailability of metalloporphyrin-based SOD mimics is greatly influenced by a single charge residing on a Mn site. 
  • Biochemical and biological studies of mouse APOBEC3. 
  • Biochemical and immunological abnormalities in purine nucleoside phosphorylase deficient mice. 
  • Biochemical characterization of purified mammalian ARL13B protein indicates that it is an atypical GTPase and ARL3 guanine nucleotide exchange factor (GEF). 
  • Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models. 
  • Biochemical identity and characterization of the mouse interleukin-2 receptor beta and gamma c subunits. 
  • Biochemical properties of recombinant human and mouse N-acetylglutamate synthase. 
  • Biocompatibility studies of functionalized regioregular poly(3-hexylthiophene) layers for sensing applications. 
  • Biodistribution of O6-benzylguanine and its effectiveness against human brain tumor xenografts when given in polyethylene glycol or cremophor-EL. 
  • Bioelectrorheological model of the cell. 5. Electrodestruction of cellular membrane in alternating electric field. 
  • Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-1alpha and PGC-1beta) in muscle cells. 
  • Bioenergetic defect associated with mKATP channel opening in a mouse model carrying a mitofusin 2 mutation. 
  • Biologic and biochemical activities of continuous macrophage cell lines P388D1 and J774.1. 
  • Biological activity of complement in vivo. Role of C5 in the accumulation of polymorphonuclear leukocytes in inflammatory exudates. 
  • Biological and biochemical consequences of global deletion of exon 3 from the ER alpha gene. 
  • Biological effects of desert dust in respiratory epithelial cells and a murine model. 
  • Biological evaluation of ring- and side-chain-substituted m-iodobenzylguanidine analogues. 
  • Biological evaluation of some biphenyl analogs of acetyl-seco-hemicholinium No. 3. 
  • Biological evaluation of some terphenyl analogs of hemicholinium No. 3. 
  • Biological function and mechanism of miR-33a in prostate cancer survival and metastasis: via downregulating Engrailed-2. 
  • Biological functions and transcriptional targets of CaRF in neurons. 
  • Biological magnetic resonance imaging using laser-polarized 129Xe. 
  • Biological pathway selection through Bayesian integrative modeling. 
  • Biological, clinical and population relevance of 95 loci for blood lipids. 
  • Biological, immunological, and biochemical evidence that HIX virus is a recombinant between Moloney leukemia virus and a murine xenotropic C type virus. 
  • Biology of adenovirus vectors with E1 and E4 deletions for liver-directed gene therapy. 
  • Biology of gliomas: potential clinical implications of glioma cellular heterogeneity. 
  • Biology of hepatocellular neoplasia in the mouse. I. Histogenesis of safrole-induced hepatocellular carcinoma. 
  • Biology of hepatocellular neoplasia in the mouse. II. Sequential enzyme histochemical analysis of BALB/c mouse liver during safrole-induced carcinogenesis. 
  • Biology of hepatocellular neoplasia in the mouse. III. Electron microscopy of safrole-induced hepatocellular adenomas and hepatocellular carcinomas. 
  • Biology of small cell lung cancer. 
  • Bioluminescence imaging to track bacterial dissemination of Yersinia pestis using different routes of infection in mice. 
  • Bioluminescence resonance energy transfer identify scaffold protein CNK1 interactions in intact cells. 
  • Bioluminescent virion shells: new tools for quantitation of AAV vector dynamics in cells and live animals. 
  • Biomaterial-mediated retroviral gene transfer using self-assembled monolayers. 
  • Biomedicine. Insulin resistance takes a trip through the ER. 
  • Biomimetic engineered muscle with capacity for vascular integration and functional maturation in vivo. 
  • Biomimetic hydrogels with immobilized ephrinA1 for therapeutic angiogenesis. 
  • Biomimetic hydrogels with pro-angiogenic properties. 
  • Biomimetic, synthetic HDL nanostructures for lymphoma. 
  • Biophysical properties of the zona pellucida measured by capillary suction: is zona hardening a mechanical phenomenon? 
  • Bioreactor model of neuromuscular junction with electrical stimulation for pharmacological potency testing. 
  • Biosynthesis and in vivo localization of the decapentaplegic-Vg-related protein, DVR-6 (bone morphogenetic protein-6). 
  • Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s). 
  • Biosynthesis of renin: multiplicity of active and intermediate forms. 
  • Birthdays of retinal amacrine cell subtypes are systematically related to their molecular identity and soma position. 
  • Bisphenol A delays the perinatal chloride shift in cortical neurons by epigenetic effects on the Kcc2 promoter. 
  • Bisphosphonates target B cells to enhance humoral immune responses. 
  • Black cohosh increases metastatic mammary cancer in transgenic mice expressing c-erbB2. 
  • Bladder sensory physiology: neuroactive compounds and receptors, sensory transducers, and target-derived growth factors as targets to improve function. 
  • Blockade of T- and B-lymphocyte development by antibody to the gamma c subunit of the receptors for interleukins 2, 4, and 7. 
  • Blockade of hyperbaric oxygen induced seizures by excitatory amino acid antagonists. 
  • Blockade of nicotinic acetylcholine receptors suppresses hippocampal long-term potentiation in wild-type but not ApoE4 targeted replacement mice. 
  • Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. 
  • Blocking CCR7 at the ocular surface impairs the pathogenic contribution of dendritic cells in allergic conjunctivitis. 
  • Blocking [211At]astatide accumulation in normal tissues: preliminary evaluation of seven potential compounds. 
  • Blocking the apoE/Aβ interaction ameliorates Aβ-related pathology in APOE ε2 and ε4 targeted replacement Alzheimer model mice. 
  • Blocking the interaction between apolipoprotein E and Aβ reduces intraneuronal accumulation of Aβ and inhibits synaptic degeneration. 
  • Blood gene expression signatures predict invasive candidiasis. 
  • Blood pressure homeostasis is maintained by a P311-TGF-β axis. 
  • Blood pressure-associated polymorphism controls ARHGAP42 expression via serum response factor DNA binding. 
  • Blood-brain barrier (BBB) disruption using a diagnostic ultrasound scanner and Definity in Mice. 
  • Blood-brain barrier dysfunction after primary blast injury in vitro. 
  • Blood-derived inflammatory dendritic cells in lymph nodes stimulate acute T helper type 1 immune responses. 
  • Blood-derived macrophages infiltrate the retina and activate Muller glial cells under experimental choroidal neovascularization. 
  • Blunted stress responses in delayed type hypersensitivity in mice lacking the neuronal isoform of nitric oxide synthase. 
  • Blurring the edges in vertebrate sex determination. 
  • Bmp Induces Osteoblast Differentiation through both Smad4 and mTORC1 Signaling. 
  • Bmp signaling is required for intestinal growth and morphogenesis. 
  • Bmp signaling regulates proximal-distal differentiation of endoderm in mouse lung development. 
  • Bmp4 and Fgf10 play opposing roles during lung bud morphogenesis. 
  • Bmp4 is essential for the formation of the vestibular apparatus that detects angular head movements. 
  • Bmp4 is required for the generation of primordial germ cells in the mouse embryo. 
  • Bmp6 regulates retinal iron homeostasis and has altered expression in age-related macular degeneration. 
  • Bmp7 regulates germ cell proliferation in mouse fetal gonads. 
  • Bmps: multifunctional regulators of mammalian embryonic development. 
  • Body composition at vaginal opening in mice as influenced by food intake and photoperiod: tests of critical body weight and composition hypotheses for puberty onset. 
  • Body weight and fat deposition in prolactin receptor-deficient mice. 
  • Body weight is not always a good predictor of longevity in mice. 
  • Bombesin and [Leu8]phyllolitorin promote fetal mouse lung branching morphogenesis via a receptor-mediated mechanism. 
  • Bombesin increases fetal lung growth and maturation in utero and in organ culture. 
  • Bombesin inhibits alveolarization and promotes pulmonary fibrosis in newborn mice. 
  • Bombesin may play a role in fetal lung growth and maturation in utero and in lung organ culture. 
  • Bombesin-like peptide receptor gene expression, regulation, and function in fetal murine lung. 
  • Bombesin-like peptides and mast cell responses: relevance to bronchopulmonary dysplasia? 
  • Bone Marrow Stress Decreases Osteogenic Progenitors. 
  • Bone formation by human postnatal bone marrow stromal stem cells is enhanced by telomerase expression. 
  • Bone histomorphometric and biomechanical abnormalities in mice homozygous for deletion of the dopamine transporter gene. 
  • Bone marrow chimeras and c-fms conditional ablation (Mafia) mice reveal an essential role for resident myeloid cells in lipopolysaccharide/TLR4-induced corneal inflammation. 
  • Bone marrow dendritic cell-mediated regulation of TLR and B cell receptor signaling in B cells. 
  • Bone marrow transplantation augments the effect of brain- and spinal cord-directed adeno-associated virus 2/5 gene therapy by altering inflammation in the murine model of globoid-cell leukodystrophy. 
  • Bone marrow transplantation transfers age-related susceptibility to neovascular remodeling in murine laser-induced choroidal neovascularization. 
  • Bone marrow-derived dendritic cells pulsed with tumor homogenate induce immunity against syngeneic intracerebral glioma. 
  • Bone marrow-derived progenitor cells contribute to experimental choroidal neovascularization. 
  • Bone marrow-generated dendritic cells pulsed with tumor extracts or tumor RNA induce antitumor immunity against central nervous system tumors. 
  • Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse. 
  • Bone morphogenetic protein 4 mediates myocardial ischemic injury through JNK-dependent signaling pathway. 
  • Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter. 
  • Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis. 
  • Bone morphogenetic protein signaling is required in the dorsal neural folds before neurulation for the induction of spinal neural crest cells and dorsal neurons. 
  • Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse. 
  • Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development. 
  • Bone-related genes expressed in advanced malignancies induce invasion and metastasis in a genetically defined human cancer model. 
  • Boosting cardiac contractility with genes. 
  • Boosting high-intensity focused ultrasound-induced anti-tumor immunity using a sparse-scan strategy that can more effectively promote dendritic cell maturation. 
  • Borg proteins control septin organization and are negatively regulated by Cdc42. 
  • Bortezomib sensitizes pancreatic cancer cells to endoplasmic reticulum stress-mediated apoptosis. 
  • Both NK cell-intrinsic and -extrinsic STAT1 signaling are required for NK cell response against vaccinia virus. 
  • Both aerobic exercise and resveratrol supplementation attenuate doxorubicin-induced cardiac injury in mice. 
  • Both hematopoietic-derived and non-hematopoietic-derived {beta}-arrestin-2 regulates murine allergic airway disease. 
  • Bovine thrombin and systemic autoimmunity. 
  • Brachytherapy using injectable seeds that are self-assembled from genetically encoded polypeptides in situ. 
  • Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition. 
  • Bradykinin produces pain hypersensitivity by potentiating spinal cord glutamatergic synaptic transmission. 
  • Brain 5-HT deficiency increases stress vulnerability and impairs antidepressant responses following psychosocial stress. 
  • Brain cancer stem cells display preferential sensitivity to Akt inhibition. 
  • Brain expression of presenilins in sporadic and early-onset, familial Alzheimer's disease. 
  • Brain inositol is a novel stimulator for promoting Cryptococcus penetration of the blood-brain barrier. 
  • Brain insulin lowers circulating BCAA levels by inducing hepatic BCAA catabolism. 
  • Brain natriuretic peptide improves long-term functional recovery after acute CNS injury in mice. 
  • Brain radiation injury leads to a dose- and time-dependent recruitment of peripheral myeloid cells that depends on CCR2 signaling. 
  • Brain trauma induces X-box protein 1 processing indicative of activation of the endoplasmic reticulum unfolded protein response. 
  • Brain tumors in man and animals: report of a workshop. 
  • Brain tumors in mice are susceptible to blockade of epidermal growth factor receptor (EGFR) with the oral, specific, EGFR-tyrosine kinase inhibitor ZD1839 (iressa). 
  • Brain-derived neurotrophic factor attenuates mouse cerebellar granule cell GABA(A) receptor-mediated responses via postsynaptic mechanisms. 
  • Brain-derived neurotrophic factor but not vesicular zinc promotes TrkB activation within mossy fibers of mouse hippocampus in vivo. 
  • Brain-specific carnitine palmitoyl-transferase-1c: role in CNS fatty acid metabolism, food intake, and body weight. 
  • Brain-wide Electrical Spatiotemporal Dynamics Encode Depression Vulnerability. 
  • Branching morphogenesis of the lung: new models for a classical problem. 
  • Brd4 coactivates transcriptional activation of NF-kappaB via specific binding to acetylated RelA. 
  • Breaking or making immunological privilege in the central nervous system: the regulation of immunity by neuropeptides. 
  • Breast Milk of HIV-Positive Mothers Has Potent and Species-Specific In Vivo HIV-Inhibitory Activity. 
  • Brefeldin A rapidly disrupts plasma membrane polarity by blocking polar sorting in common endosomes of MDCK cells. 
  • Bromelain treatment decreases neutrophil migration to sites of inflammation. 
  • Bromodeoxyuridine-mediated radiosensitization in human glioma: the effect of concentration, duration, and fluoropyrimidine modulation. 
  • Bronchial and bronchiolar fibrosis in rats exposed to 2,3-pentanedione vapors: implications for bronchiolitis obliterans in humans. 
  • Bronchial epithelial injury in the context of alloimmunity promotes lymphocytic bronchiolitis through hyaluronan expression. 
  • Brush border enzyme-cleavable linkers: Evaluation for reducing renal uptake of radiolabeled prostate-specific membrane antigen inhibitors. 
  • Building and maintaining the epithelium of the lung. 
  • Building and re-building the heart by cardiomyocyte proliferation. 
  • Burst-Dependent Bidirectional Plasticity in the Cerebellum Is Driven by Presynaptic NMDA Receptors. 
  • Busulfan therapy of central nervous system xenografts in athymic mice. 
  • Buthionine sulfoximine-mediated depletion of glutathione in intracranial human glioma-derived xenografts. 
  • C-C Motif Chemokine 5 Attenuates Angiotensin II-Dependent Kidney Injury by Limiting Renal Macrophage Infiltration. 
  • C-myc-induced apoptosis in polycystic kidney disease is Bcl-2 and p53 independent. 
  • C-terminal deletion of the atrophin-1 protein results in growth retardation but not neurodegeneration in mice. 
  • C-terminal regions of the human telomerase catalytic subunit essential for in vivo enzyme activity. 
  • C-type virus particles in human urogenital tumours after heterotransplantation into nude mice. 
  • C3orf58, a novel paracrine protein, stimulates cardiomyocyte cell-cycle progression through the PI3K-AKT-CDK7 pathway. 
  • CAPER is vital for energy and redox homeostasis by integrating glucose-induced mitochondrial functions via ERR-α-Gabpa and stress-induced adaptive responses via NF-κB-cMYC. 
  • CBF, Myb, and Ets binding sites are important for activity of the core I element of the murine retrovirus SL3-3 in T lymphocytes. 
  • CCAAT/enhancer-binding protein alpha is required for transcription of the beta 3-adrenergic receptor gene during adipogenesis. 
  • CCAAT/enhancer-binding protein beta deletion reduces adiposity, hepatic steatosis, and diabetes in Lepr(db/db) mice. 
  • CCDC62/ERAP75 functions as a coactivator to enhance estrogen receptor beta-mediated transactivation and target gene expression in prostate cancer cells. 
  • CCL-21 conditioned regulatory T cells induce allotolerance through enhanced homing to lymphoid tissue. 
  • CCM1 and CCM2 protein interactions in cell signaling: implications for cerebral cavernous malformations pathogenesis. 
  • CCN1 Regulates Chondrocyte Maturation and Cartilage Development. 
  • CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension. 
  • CCR2+ monocyte-derived dendritic cells and exudate macrophages produce influenza-induced pulmonary immune pathology and mortality. 
  • CCR2-antagonist prophylaxis reduces pulmonary immune pathology and markedly improves survival during influenza infection. 
  • CCR7 is critical for the induction and maintenance of Th17 immunity in dry eye disease. 
  • CCSP regulates cross talk between secretory cells and both ciliated cells and macrophages of the conducting airway. 
  • CD10/neutral endopeptidase 24.11 regulates fetal lung growth and maturation in utero by potentiating endogenous bombesin-like peptides. 
  • CD11c(+)B220(+)Gr-1(+) cells in mouse lymph nodes and spleen display characteristics of plasmacytoid dendritic cells. 
  • CD14 is an essential mediator of LPS-induced airway disease. 
  • CD14-dependent mechanism for endotoxin-mediated nitric oxide synthesis in murine macrophages. 
  • CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation. 
  • CD19 amplifies B lymphocyte signal transduction by regulating Src-family protein tyrosine kinase activation. 
  • CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling. 
  • CD19 and CD22 regulate a B lymphocyte signal transduction pathway that contributes to autoimmunity. 
  • CD19 can regulate B lymphocyte signal transduction independent of complement activation. 
  • CD19 expression in B cells is important for suppression of contact hypersensitivity. 
  • CD19 expression in B cells regulates atopic dermatitis in a mouse model. 
  • CD19 expression levels regulate B lymphocyte development: human CD19 restores normal function in mice lacking endogenous CD19. 
  • CD19 hyperexpression augments Sle1-induced humoral autoimmunity but not clinical nephritis. 
  • CD19 maps to a region of conservation between human chromosome 16 and mouse chromosome 7. 
  • CD19 regulates B lymphocyte responses to transmembrane signals. 
  • CD19 regulates B lymphocyte signaling thresholds critical for the development of B-1 lineage cells and autoimmunity. 
  • CD19 regulates Src family protein tyrosine kinase activation in B lymphocytes through processive amplification. 
  • CD19 regulates innate immunity by the toll-like receptor RP105 signaling in B lymphocytes. 
  • CD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma. 
  • CD19 regulates the development of bleomycin-induced pulmonary fibrosis in a mouse model. 
  • CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction. 
  • CD19, a response regulator of B lymphocytes, regulates wound healing through hyaluronan-induced TLR4 signaling. 
  • CD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouse. 
  • CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes. 
  • CD19: a promising B cell target for rheumatoid arthritis. 
  • CD20 deficiency in humans results in impaired T cell-independent antibody responses. 
  • CD21/35 promotes protective immunity to Streptococcus pneumoniae through a complement-independent but CD19-dependent pathway that regulates PD-1 expression. 
  • CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions. 
  • CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux. 
  • CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice. 
  • CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo. 
  • CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor. 
  • CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms. 
  • CD22 regulates time course of both B cell division and antibody response. 
  • CD22 serves as a receptor for soluble IgM. 
  • CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling. 
  • CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction. 
  • CD25+CD4+ regulatory T cell migration requires L-selectin expression: L-selectin transcriptional regulation balances constitutive receptor turnover. 
  • CD26 inhibition enhances allogeneic donor-cell homing and engraftment after in utero hematopoietic-cell transplantation. 
  • CD28 costimulatory signal induces protein arginine methylation in T cells. 
  • CD28 is required for germinal center formation. 
  • CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to beta-amyloid fibrils. 
  • CD36-dependent signaling mediates fatty acid-induced gut release of secretin and cholecystokinin. 
  • CD4 T cells are required for CD8 T cell survival during both primary and memory recall responses. 
  • CD4 enhances T cell sensitivity to antigen by coordinating Lck accumulation at the immunological synapse. 
  • CD4(+)CD25(+)Foxp3(+) regulatory T cells promote Th17 cells in vitro and enhance host resistance in mouse Candida albicans Th17 cell infection model. 
  • CD4+ T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independent. 
  • CD4+CD45RBHi T cell transfer induced colitis in mice is accompanied by osteopenia which is treatable with recombinant human osteoprotegerin. 
  • CD4+Thy1- thymocytes with a Th-type 2 cytokine response. 
  • CD40 ligand-dependent T cell activation: requirement of B7-CD28 signaling through CD40. 
  • CD44 is a negative regulator of acute pulmonary inflammation and lipopolysaccharide-TLR signaling in mouse macrophages. 
  • CD44 is the signaling component of the macrophage migration inhibitory factor-CD74 receptor complex. 
  • CD44 regulates macrophage recruitment to the lung in lipopolysaccharide-induced airway disease. 
  • CD44--a molecule involved in leukocyte adherence and T-cell activation. 
  • CD6. 
  • CD62L- memory T cells enhance T-cell regeneration after allogeneic stem cell transplantation by eliminating host resistance in mice. 
  • CD69 gene is differentially regulated in T and B cells by evolutionarily conserved promoter-distal elements. 
  • CD7 and CD28 are required for murine CD4+CD25+ regulatory T cell homeostasis and prevention of thyroiditis. 
  • CD8 positive T cells influence antigen-specific immune responses through the expression of chemokines. 
  • CD8(+)NKR-P1A (+)T cells preferentially accumulate in human liver. 
  • CD83 expression influences CD4+ T cell development in the thymus. 
  • CD83 expression is a sensitive marker of activation required for B cell and CD4+ T cell longevity in vivo. 
  • CD83 influences cell-surface MHC class II expression on B cells and other antigen-presenting cells. 
  • CD83: a regulatory molecule of the immune system with great potential for therapeutic application. 
  • CD86 (B7-2) can function to drive MHC-restricted antigen-specific CTL responses in vivo. 
  • CD95 (Fas)-dependent elimination of self-reactive B cells upon interaction with CD4+ T cells. 
  • CD98-Mediated Adhesive Signaling Enables the Establishment and Propagation of Acute Myelogenous Leukemia. 
  • CDK4 regulation by TNFR1 and JNK is required for NF-kappaB-mediated epidermal growth control. 
  • CEA/CD3-bispecific T cell-engaging (BiTE) antibody-mediated T lymphocyte cytotoxicity maximized by inhibition of both PD1 and PD-L1. 
  • CERKL interacts with mitochondrial TRX2 and protects retinal cells from oxidative stress-induced apoptosis. 
  • CFLAR/c-FLIPL: a star in the autophagy, apoptosis and necroptosis alliance. 
  • CFTR as a cAMP-dependent regulator of sodium channels. 
  • CHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression. 
  • CHMP5 is essential for late endosome function and down-regulation of receptor signaling during mouse embryogenesis. 
  • CIP2A mediates erlotinib-induced apoptosis in non-small cell lung cancer cells without EGFR mutation. 
  • CK1epsilon is required for breast cancers dependent on beta-catenin activity. 
  • CK1δ/ε protein kinase primes the PER2 circadian phosphoswitch. 
  • CLN3p impacts galactosylceramide transport, raft morphology, and lipid content. 
  • CNS inflammation and bone marrow neuropathy in type 1 diabetes. 
  • CNS myelin wrapping is driven by actin disassembly. 
  • COG1410, a novel apolipoprotein E-based peptide, improves functional recovery in a murine model of traumatic brain injury. 
  • COX-2-derived prostacyclin modulates vascular remodeling. 
  • CREB and ChREBP oppositely regulate SIRT1 expression in response to energy availability. 
  • CRISPR/Cas9 Editing of Murine Induced Pluripotent Stem Cells for Engineering Inflammation-Resistant Tissues. 
  • CSPG4 protein as a new target for the antibody-based immunotherapy of triple-negative breast cancer. 
  • CTLA-4-Mediated inhibition of early events of T cell proliferation. 
  • CX3CR1 deficiency impairs dendritic cell accumulation in arterial intima and reduces atherosclerotic burden. 
  • CX3CR1+ interstitial dendritic cells form a contiguous network throughout the entire kidney. 
  • CX3CR1-dependent renal macrophage survival promotes Candida control and host survival. 
  • CXCL13 drives spinal astrocyte activation and neuropathic pain via CXCR5. 
  • CXCR1-mediated neutrophil degranulation and fungal killing promote Candida clearance and host survival. 
  • CXCR4 enhances adhesion of B16 tumor cells to endothelial cells in vitro and in vivo via beta(1) integrin. 
  • CYLD deubiquitinates RIP1 in the TNFα-induced necrosome to facilitate kinase activation and programmed necrosis. 
  • CYLD inhibits tumorigenesis and metastasis by blocking JNK/AP1 signaling at multiple levels. 
  • CYP27A1 Loss Dysregulates Cholesterol Homeostasis in Prostate Cancer. 
  • CYP2E1-dependent and leptin-mediated hepatic CD57 expression on CD8+ T cells aid progression of environment-linked nonalcoholic steatohepatitis. 
  • Ca(2+)-regulated serine protease associated with the nuclear scaffold. 
  • Ca(2+)/calmodulin-dependent protein kinase IV is expressed in spermatids and targeted to chromatin and the nuclear matrix. 
  • Ca2+ entry via alpha1G and TRPV4 channels differentially regulates surface expression of P-selectin and barrier integrity in pulmonary capillary endothelium. 
  • Ca2+/calmodulin-dependent protein kinase II (CaMKII) regulates cardiac sodium channel NaV1.5 gating by multiple phosphorylation sites. 
  • CaMKII is essential for the proasthmatic effects of oxidation. 
  • Cadherin-11 expressed in association with mesenchymal morphogenesis in the head, somite, and limb bud of early mouse embryos. 
  • Cadherin-6 expression transiently delineates specific rhombomeres, other neural tube subdivisions, and neural crest subpopulations in mouse embryos. 
  • Cadmium-induced DNA synthesis and cell proliferation in macrophages: the role of intracellular calcium and signal transduction mechanisms. 
  • Cadmium-induced neoplastic transformation of human prostate epithelial cells. 
  • Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice. 
  • CalDAG-GEFI down-regulation in the striatum as a neuroprotective change in Huntington's disease. 
  • Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo. 
  • Calcineurin activation causes retinal ganglion cell degeneration. 
  • Calcineurin controls drug tolerance, hyphal growth, and virulence in Candida dubliniensis. 
  • Calcineurin controls growth, morphology, and pathogenicity in Aspergillus fumigatus. 
  • Calcineurin controls hyphal growth, virulence, and drug tolerance of Candida tropicalis. 
  • Calcineurin governs thermotolerance and virulence of Cryptococcus gattii. 
  • Calcineurin inhibition with systemic FK506 treatment increases dendritic branching and dendritic spine density in healthy adult mouse brain. 
  • Calcineurin is essential for Candida albicans survival in serum and virulence. 
  • Calcineurin is required for pseudohyphal growth, virulence, and drug resistance in Candida lusitaniae. 
  • Calcineurin mediates pancreatic growth in protease inhibitor-treated mice. 
  • Calcineurin mutants render T lymphocytes resistant to cyclosporin A. 
  • Calcineurin orchestrates dimorphic transitions, antifungal drug responses and host-pathogen interactions of the pathogenic mucoralean fungus Mucor circinelloides. 
  • Calcineurin promotes infection of the cornea by Candida albicans and can be targeted to enhance fluconazole therapy. 
  • Calcineurin regulatory subunit is essential for virulence and mediates interactions with FKBP12-FK506 in Cryptococcus neoformans. 
  • Calcineurin target CrzA regulates conidial germination, hyphal growth, and pathogenesis of Aspergillus fumigatus. 
  • Calcitonin driven v-Ha-ras induces multilineage pulmonary epithelial hyperplasias and neoplasms. 
  • Calcitonin gene-related peptide (CGRP) in the developing mouse limb. 
  • Calcitonin stimulation of renal 25-hydroxyvitamin D-1 alpha-hydroxylase activity in hypophosphatemic mice. Evidence that the regulation of calcitriol production is not universally abnormal in X-linked hypophosphatemia. 
  • Calcium binding domains and calcium-induced conformational transition of SPARC/BM-40/osteonectin, an extracellular glycoprotein expressed in mineralized and nonmineralized tissues. 
  • Calcium dependent CAMTA1 in adult stem cell commitment to a myocardial lineage. 
  • Calcium influx through L-type CaV1.2 Ca2+ channels regulates mandibular development. 
  • Calcium, calmodulin and cell proliferation. 
  • Calcium-activated chloride channel TMEM16A modulates mucin secretion and airway smooth muscle contraction. 
  • Calcium-dependent regulation of cholecystokinin secretion and potassium currents in STC-1 cells. 
  • Calcium/calmodulin-dependent kinase kinase 2 regulates hematopoietic stem and progenitor cell regeneration. 
  • Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses. 
  • Calcium/calmodulin-dependent protein kinase kinase 2: roles in signaling and pathophysiology. 
  • Calibration-free absolute quantification of particle concentration by statistical analyses of photoacoustic signals in vivo. 
  • Calibration-free structured-illumination photoacoustic flowgraphy of transverse flow in scattering media. 
  • Calmodulin as a regulator of cell growth and gene expression. 
  • Calmodulin as an integral subunit of phosphorylase kinase from rabbit skeletal muscle. 
  • Calmodulin is involved in regulation of cell proliferation. 
  • Calmodulin is required for cell-cycle progression during G1 and mitosis. 
  • Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase. 
  • Calmodulin-dependent kinase IV links Toll-like receptor 4 signaling with survival pathway of activated dendritic cells. 
  • Calmodulin-dependent protein kinase IV regulates hematopoietic stem cell maintenance. 
  • Calmodulin-induced early-onset diabetes in transgenic mice. 
  • Calmodulin-microtubule association in cultured mammalian cells. 
  • Calorie restriction reduces oxidative stress by SIRT3-mediated SOD2 activation. 
  • Calreticulin chaperones regulate functional expression of vomeronasal type 2 pheromone receptors. 
  • Calreticulin displays in vivo peptide-binding activity and can elicit CTL responses against bound peptides. 
  • Calspermin gene transcription is regulated by two cyclic AMP response elements contained in an alternative promoter in the calmodulin kinase IV gene. 
  • Can Ceftazidime-Avibactam and Aztreonam Overcome β-Lactam Resistance Conferred by Metallo-β-Lactamases in Enterobacteriaceae? 
  • Can the thymus win the battle against drug-resistant HIV? 
  • Cancer immunotherapy innovator James Allison receives the 2015 Lasker~DeBakey Clinical Medical Research Award. 
  • Cancer in rodents: does it tell us about cancer in humans? 
  • Cancer stem cells and survival pathways. 
  • Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma. 
  • Cancer-cell-secreted exosomal miR-105 promotes tumour growth through the MYC-dependent metabolic reprogramming of stromal cells. 
  • Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. 
  • Candidate selection and preclinical evaluation of N-tert-butyl isoquine (GSK369796), an affordable and effective 4-aminoquinoline antimalarial for the 21st century. 
  • Canine cyclin T1 rescues equine infectious anemia virus tat trans-activation in human cells. 
  • Cannabinoids and the gut. 
  • Cannabinoids. Synthesis and central nervous system activity of 8-substituted 10-hydroxy-5,5-dimethyl-5H-[1]benzopyrano[4,3-c]pyridine and derivatives. 
  • Canonical Inflammasomes Drive IFN-γ to Prime Caspase-11 in Defense against a Cytosol-Invasive Bacterium. 
  • Canonical Wnt signaling induces vascular endothelial dysfunction via p66Shc-regulated reactive oxygen species. 
  • Canonical Wnt9b signaling balances progenitor cell expansion and differentiation during kidney development. 
  • Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways. 
  • Capric acid and hydroxypropylmethylcellulose increase the immunogenicity of nasally administered peptide vaccines. 
  • Capsaicin vanilloid receptor-1 mediates substance P release in experimental pancreatitis. 
  • Capsule production and growth phase influence binding of complement to Staphylococcus aureus. 
  • Capture of phosphopeptides using alpha-zirconium phosphate nanoplatelets. 
  • Capturing and Manipulating Activated Neuronal Ensembles with CANE Delineates a Hypothalamic Social-Fear Circuit. 
  • Capturing change in clonal composition amongst single mouse germinal centers. 
  • Car8 dorsal root ganglion expression and genetic regulation of analgesic responses are associated with a cis-eQTL in mice. 
  • Carbohydrate changes in pre- and peri-implantation mouse embryos as detected by a monoclonal antibody. 
  • Carbohydrate recognition systems in amphibians: primitive alpha 2-macroglobulin receptors. 
  • Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer. 
  • Carbohydrate restriction, prostate cancer growth, and the insulin-like growth factor axis. 
  • Carbon chain shape selectivity by the mouse olfactory receptor OR-I7. 
  • Carbon monoxide and heme oxygenase-1 prevent intestinal inflammation in mice by promoting bacterial clearance. 
  • Carbonic anhydrase-8 regulates inflammatory pain by inhibiting the ITPR1-cytosolic free calcium pathway. 
  • Carcinogen 7,12-dimethylbenz[a]anthracene-induced mammary tumorigenesis is accelerated in Smad3 heterozygous mice compared to Smad3 wild type mice. 
  • Carcinogen induced unscheduled DNA synthesis in mouse hepatocytes. 
  • Carcinogenicity and toxicity of inhaled nitrobenzene in B6C3F1 mice and F344 and CD rats. 
  • Carcinogenicity of inhaled benzene in CBA mice. 
  • Cardiac BIN1 folds T-tubule membrane, controlling ion flux and limiting arrhythmia. 
  • Cardiac GPCRs: GPCR signaling in healthy and failing hearts. 
  • Cardiac Pressure-Volume Loop Analysis Using Conductance Catheters in Mice. 
  • Cardiac arrest/cardiopulmonary resuscitation augments cell-mediated immune function and transiently suppresses humoral immune function. 
  • Cardiac arterial pole alignment is sensitive to FGF8 signaling in the pharynx. 
  • Cardiac beta ARK1 inhibition prolongs survival and augments beta blocker therapy in a mouse model of severe heart failure. 
  • Cardiac cell therapy in vitro: reproducible assays for comparing the efficacy of different donor cells. 
  • Cardiac copper deficiency activates a systemic signaling mechanism that communicates with the copper acquisition and storage organs. 
  • Cardiac function in genetically engineered mice with altered adrenergic receptor signaling. 
  • Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. 
  • Cardiac function in mice overexpressing the beta-adrenergic receptor kinase or a beta ARK inhibitor. 
  • Cardiac gene expression profiling provides evidence for cytokinopathy as a molecular mechanism in Chagas' disease cardiomyopathy. 
  • Cardiac hypertrophy and altered beta-adrenergic signaling in transgenic mice that express the amino terminus of beta-ARK1. 
  • Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene. 
  • Cardiac micro-computed tomography for morphological and functional phenotyping of muscle LIM protein null mice. 
  • Cardiac overexpression of a G(q) inhibitor blocks induction of extracellular signal-regulated kinase and c-Jun NH(2)-terminal kinase activity in in vivo pressure overload. 
  • Cardiac phenotype and angiotensin II levels in AT1a, AT1b, and AT2 receptor single, double, and triple knockouts. 
  • Cardiac rupture after myocardial infarction: new insights from murine models. 
  • Cardiac-specific LIM protein FHL2 modifies the hypertrophic response to beta-adrenergic stimulation. 
  • Cardiac-specific expression of heme oxygenase-1 protects against ischemia and reperfusion injury in transgenic mice. 
  • Cardiac-specific mindin overexpression attenuates cardiac hypertrophy via blocking AKT/GSK3β and TGF-β1-Smad signalling. 
  • Cardiac-specific overexpression of angiotensin II AT2 receptor causes attenuated response to AT1 receptor-mediated pressor and chronotropic effects. 
  • Cardiolipin polyspecific autoreactivity in two broadly neutralizing HIV-1 antibodies. 
  • Cardiomyocyte-Specific Human Bcl2-Associated Anthanogene 3 P209L Expression Induces Mitochondrial Fragmentation, Bcl2-Associated Anthanogene 3 Haploinsufficiency, and Activates p38 Signaling. 
  • Cardiopatch platform enables maturation and scale-up of human pluripotent stem cell-derived engineered heart tissues. 
  • Cardioprotective and antiapoptotic effects of heme oxygenase-1 in the failing heart. 
  • Cardioprotective effects of 70-kDa heat shock protein in transgenic mice. 
  • Cardioprotective proteins upregulated in the liver in response to experimental myocardial ischemia. 
  • Cardioprotective role of S-nitrosylated hemoglobin from rbc. 
  • Cardiovascular abnormalities in transgenic mice with reduced brown fat: an animal model of human obesity. 
  • Cardiovascular phenotype of mice lacking all three subtypes of angiotensin II receptors. 
  • Cardiovascular phenotyping of the mouse heart using a 4D radial acquisition and liposomal Gd-DTPA-BMA. 
  • Cardiovascular responses to the isoprostanes iPF(2alpha)-III and iPE(2)-III are mediated via the thromboxane A(2) receptor in vivo. 
  • Carnitine revisited: potential use as adjunctive treatment in diabetes. 
  • Cartilage tissue engineering using differentiated and purified induced pluripotent stem cells. 
  • Cartilage tissue engineering: Directed differentiation of embryonic stem cells in three-dimensional hydrogel culture. 
  • Cartilage tumours and bone development: molecular pathology and possible therapeutic targets. 
  • Cartilage-Specific Knockout of the Mechanosensory Ion Channel TRPV4 Decreases Age-Related Osteoarthritis. 
  • Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development. 
  • Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development. 
  • Casein kinase 1α-dependent feedback loop controls autophagy in RAS-driven cancers. 
  • Casein kinase I in the mammalian circadian clock. 
  • Caspase 3 promotes surviving melanoma tumor cell growth after cytotoxic therapy. 
  • Caspase 3-mediated stimulation of tumor cell repopulation during cancer radiotherapy. 
  • Caspase 8 small interfering RNA prevents acute liver failure in mice. 
  • Caspase-2 promotes obesity, the metabolic syndrome and nonalcoholic fatty liver disease. 
  • Caspase-3 cleavage links delta-catenin to the novel nuclear protein ZIFCAT. 
  • Caspase-3 dependent cleavage and activation of skeletal muscle phosphorylase b kinase. 
  • Caspase-3 promotes genetic instability and carcinogenesis. 
  • Caspase-8 and RIP kinases regulate bacteria-induced innate immune responses and cell death. 
  • Caspase-8 and caspase-3 small interfering RNA decreases ischemia/reperfusion injury to the liver in mice. 
  • Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. 
  • Caspase-cleavage of tau is an early event in Alzheimer disease tangle pathology. 
  • Caspase-dependent cleavage of carbamoyl phosphate synthetase II during apoptosis. 
  • Catabolic Defect of Branched-Chain Amino Acids Promotes Heart Failure. 
  • Catabolic pathways for streptokinase, plasmin, and streptokinase activator complex in mice. In vivo reaction of plasminogen activator with alpha 2-macroglobulin. 
  • Catabolism of human tissue plasminogen activator in mice. 
  • Catabolism of radioiodinated murine monoclonal antibody F(ab')2 fragment labeled using N-succinimidyl 3-iodobenzoate and Iodogen methods. 
  • Catabolism of streptokinase and polyethylene glycol-streptokinase: evidence for transport of intact forms through the biliary system in the mouse. 
  • Catecholamine release and uptake in the mouse prefrontal cortex. 
  • Catecholamine synthesis is mediated by tyrosinase in the absence of tyrosine hydroxylase. 
  • Catecholaminergic cell lines from the brain and adrenal glands of tyrosine hydroxylase-SV40 T antigen transgenic mice. 
  • Catecholamines act via a beta-adrenergic receptor to maintain fetal heart rate and survival. 
  • Categorical scaling of duration bisection in pigeons (Columba livia), mice (Mus musculus), and humans (Homo sapiens). 
  • Cathepsin K-sensitive poly(ethylene glycol) hydrogels for degradation in response to bone resorption. 
  • Cathepsin Protease Controls Copper and Cisplatin Accumulation via Cleavage of the Ctr1 Metal-binding Ectodomain. 
  • Cathepsin S causes inflammatory pain via biased agonism of PAR2 and TRPV4. 
  • Caveolin-1 modulates intraocular pressure: implications for caveolae mechanoprotection in glaucoma. 
  • Cch1 mediates calcium entry in Cryptococcus neoformans and is essential in low-calcium environments. 
  • Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations. 
  • Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition. 
  • Cdc6 is regulated by E2F and is essential for DNA replication in mammalian cells. 
  • Ceftaroline: a cephalosporin with expanded Gram-positive activity. 
  • Ceftriaxone pharmacokinetics in interleukin-10-treated murine pneumococcal pneumonia. 
  • Celecoxib does not delay cutaneous wound healing in haemophilia B mice. 
  • Celecoxib inhibits vascular endothelial growth factor expression in and reduces angiogenesis and metastasis of human pancreatic cancer via suppression of Sp1 transcription factor activity. 
  • Cell adhesion molecules regulate fibrotic process via Th1/Th2/Th17 cell balance in a bleomycin-induced scleroderma model. 
  • Cell adhesion: separation of p120's powers? 
  • Cell binding and tumor inhibiting functions of a new antihuman melanoma murine monoclonal antibody. 
  • Cell binding specificity of mouse R-cadherin and chromosomal mapping of the gene. 
  • Cell biology. Propelling progeny. 
  • Cell cycle regulation of the E2F transcription factor involves an interaction with cyclin A. 
  • Cell cycle-dependent localization of macroH2A in chromatin of the inactive X chromosome. 
  • Cell cycle-independent death of prostate adenocarcinoma is induced by the trk tyrosine kinase inhibitor CEP-751 (KT6587). 
  • Cell death in age-related macular degeneration. 
  • Cell interactions and endoderm differentiation in cultured mouse embryos. 
  • Cell interactions modulate embryonal carcinoma cell differentiation into parietal or visceral endoderm. 
  • Cell lineage mapping of taste bud cells and keratinocytes in the mouse tongue and soft palate. 
  • Cell mediated contraction in 3D cell-matrix constructs leads to spatially regulated osteogenic differentiation. 
  • Cell polarization defects in early heart development. 
  • Cell population dynamics model for deconvolution of murine embryonic stem cell self-renewal and differentiation responses to cytokines and extracellular matrix. 
  • Cell proliferation contributes to PNEC hyperplasia after acute airway injury. 
  • Cell proliferation is necessary for the determination of male fate in the gonad. 
  • Cell surface localization and density of the tumor-associated variant of the epidermal growth factor receptor, EGFRvIII. 
  • Cell surface-associated proteins which bind native type IV collagen or gelatin. 
  • Cell therapy for diverse central nervous system disorders: inherited metabolic diseases and autism. 
  • Cell therapy in murine atherosclerosis: in vivo imaging with high-resolution helical SPECT. 
  • Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration. 
  • Cell-Type-Specific Optical Recording of Membrane Voltage Dynamics in Freely Moving Mice. 
  • Cell-autonomous adiposity through increased cell surface GLUT4 due to ankyrin-B deficiency. 
  • Cell-based gene therapy for repair of critical size defects in the rat fibula. 
  • Cell-cell adhesions and cell contractility are upregulated upon desmosome disruption. 
  • Cell-cell interactions and bronchoconstrictor eicosanoid reduction with inhaled carbon monoxide and resolvin D1. 
  • Cell-dependent posttranslational processing and secretion of recombinant mouse renin-2. 
  • Cell-mediated cytotoxicity of murine cytomegalovirus-infected target cells allows for release of residual infectious virus. 
  • Cell-mediated immune responses to vaccine peptides derived from the circumsporozoite protein of Plasmodium falciparum. 
  • Cell-surface co-receptors: emerging roles in signaling and human disease. 
  • Cells en route to apoptosis are characterized by the upregulation of c-fos, c-myc, c-jun, cdc2, and RB phosphorylation, resembling events of early cell-cycle traverse. 
  • Cells of renin lineage are progenitors of podocytes and parietal epithelial cells in experimental glomerular disease 
  • Cells treated with TAP-2 antisense oligonucleotides are potent antigen-presenting cells in vitro and in vivo. 
  • Cellular FLIP Inhibits Myeloid Cell Activation by Suppressing Selective Innate Signaling. 
  • Cellular Sites and Mechanisms Linking Reduction of Dipeptidyl Peptidase-4 Activity to Control of Incretin Hormone Action and Glucose Homeostasis. 
  • Cellular and Circuitry Bases of Autism: Lessons Learned from the Temporospatial Manipulation of Autism Genes in the Brain. 
  • Cellular and functional defects in a mouse model of heart failure. 
  • Cellular and humoral immune responses to alphavirus replicon vaccines expressing cytomegalovirus pp65, IE1, and gB proteins. 
  • Cellular and humoral immune responses to viral antigens create barriers to lung-directed gene therapy with recombinant adenoviruses. 
  • Cellular and molecular responses of the uterus to embryo implantation can be elicited by locally applied growth factors. 
  • Cellular and viral splicing factors can modify the splicing pattern of CFTR transcripts carrying splicing mutations. 
  • Cellular cytoskeleton dynamics modulates non-viral gene delivery through RhoGTPases. 
  • Cellular determinants of reduced adaptability of the aging brain: neurotransmitter utilization and cell signaling responses after MDMA lesions. 
  • Cellular engineering for the treatment of metabolic disorders: prospects for therapy in diabetes. 
  • Cellular gene expression in papillomas of the choroid plexus from transgenic mice that express the simian virus 40 large T antigen. 
  • Cellular immune response to cryptic epitopes during therapeutic gene transfer. 
  • Cellular immune responses in neonates. 
  • Cellular immunity to viral antigens limits E1-deleted adenoviruses for gene therapy. 
  • Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. 
  • Cellular interactions implicated in the mechanism of photoreceptor degeneration in transgenic mice expressing a mutant rhodopsin gene. 
  • Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis. 
  • Cellular redox modulator, ortho Mn(III) meso-tetrakis(N-n-hexylpyridinium-2-yl)porphyrin, MnTnHex-2-PyP(5+) in the treatment of brain tumors. 
  • Cellular requirements for anti-DNA production induced in mice by immunization with bacterial DNA. 
  • Cellular serine proteinase induces chemotaxis by complement activation. 
  • Central and peripheral effects of insulin/IGF-1 signaling in aging and cancer: antidiabetic drugs as geroprotectors and anticarcinogens. 
  • Central memory self/tumor-reactive CD8+ T cells confer superior antitumor immunity compared with effector memory T cells. 
  • Central nervous system imprinting of the G protein G(s)alpha and its role in metabolic regulation. 
  • Central tolerance regulates B cells reactive with Goodpasture antigen alpha3(IV)NC1 collagen. 
  • Centrifugal migration of mesenchymal cells in embryonic lung. 
  • CerS2 haploinsufficiency inhibits β-oxidation and confers susceptibility to diet-induced steatohepatitis and insulin resistance. 
  • Ceramides and glucosylceramides are independent antagonists of insulin signaling. 
  • Cerebellar defects in Ca2+/calmodulin kinase IV-deficient mice. 
  • Cerebral 5-HT2A receptor binding, but not mGluR2, is increased in tryptophan hydroxylase 2 decrease-of-function mice. 
  • Cerebroside sulfotransferase deficiency ameliorates L-selectin-dependent monocyte infiltration in the kidney after ureteral obstruction. 
  • Cerium Oxide Nanoparticles: A Potential Medical Countermeasure to Mitigate Radiation-Induced Lung Injury in CBA/J Mice. 
  • Ceruloplasmin/hephaestin knockout mice model morphologic and molecular features of AMD. 
  • Cervicovaginal secretions contribute to innate resistance to herpes simplex virus infection. 
  • Cessation of biomechanical stretch model of C2C12 cells models myocyte atrophy and anaplerotic changes in metabolism using non-targeted metabolomics analysis. 
  • ChREBP regulates fructose-induced glucose production independently of insulin signaling. 
  • Challenges of comparative expression profiling studies of complex diseases: mouse models of myocardial hypertrophy. Focus on "Divergent transcriptional responses to independent genetic causes of cardiac hypertrophy". 
  • Changes in Hepatic TRβ Protein Expression, Lipogenic Gene Expression, and Long-Chain Acylcarnitine Levels During Chronic Hyperthyroidism and Triiodothyronine Withdrawal in a Mouse Model. 
  • Changes in extracellular calcium and magnesium and synaptic transmission in isolated mouse spinal cord. 
  • Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging. 
  • Changes in macrophages and their functions with aging in C57BL/6J, AKR/J, and SJL/J mice. 
  • Changes in magnetization transfer MRI correlate with spreading depression-induced astroglial reactivity and increased protein expression in mice. 
  • Changes in the behaviour of teratocarcinoma cells cultivated in vitro. 
  • Changes in the binding of "fast"-form alpha 2-macroglobulin to 3T3-L1 cells after differentiation to adipocytes. 
  • Changes in the dendritic branching of adult mammalian neurones revealed by repeated imaging in situ. 
  • Changes in the phosphorylation of initiation factor eIF-2alpha, elongation factor eEF-2 and p70 S6 kinase after transient focal cerebral ischaemia in mice. 
  • Changes in the rate of laminin and entactin synthesis in F9 embryonal carcinoma cells treated with retinoic acid and cyclic amp. 
  • Chaperoning epigenetics: FKBP51 decreases the activity of DNMT1 and mediates epigenetic effects of the antidepressant paroxetine. 
  • Characterisation of [125I]-Tyr0DTrp8-somatostatin binding in sst1- to sst4- and SRIF-gene-invalidated mouse brain. 
  • Characterisation of systemic dissemination of nonreplicating adenoviral vectors from tumours in local gene delivery. 
  • Characteristics of Candida albicans adherence to mouse tissues. 
  • Characteristics of Vibration that Alter Cardiovascular Parameters in Mice. 
  • Characterization and Functional Phenotyping of Renal Immune Cells via Flow Cytometry. 
  • Characterization and comparison of commercially available antinuclear antibody kits using single pattern index sera. 
  • Characterization and expression of a rice RAD23 gene. 
  • Characterization and expression of the complementary DNA encoding rat histidine decarboxylase. 
  • Characterization and idiotypic analysis of an anti-RNP monoclonal antibody. 
  • Characterization and regulation of the trehalose synthesis pathway and its importance in the pathogenicity of Cryptococcus neoformans. 
  • Characterization and solubilization of pyrrole-imidazole polyamide aggregates. 
  • Characterization and tissue expression of multiple triiodothyronine receptor-auxiliary proteins and their relationship to the retinoid X-receptors. 
  • Characterization of 67 kD laminin receptor, a protein whose gene is overexpressed on treatment of cells with anti-benzo[a]pyrene-7,8-diol-9,10-epoxide. 
  • Characterization of Adipogenic Activity of House Dust Extracts and Semi-Volatile Indoor Contaminants in 3T3-L1 Cells. 
  • Characterization of Adipogenic Chemicals in Three Different Cell Culture Systems: Implications for Reproducibility Based on Cell Source and Handling. 
  • Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation. 
  • Characterization of Fatty Acid Binding Protein 7 (FABP7) in the Murine Retina. 
  • Characterization of Langerin-expressing dendritic cell subsets in the normal cornea. 
  • Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout background. 
  • Characterization of PDK2 activity against protein kinase B gamma. 
  • Characterization of Plasmodium liver stage inhibition by halofuginone. 
  • Characterization of a CD6 ligand(s) expressed on human- and murine-derived cell lines and murine lymphoid tissues. 
  • Characterization of a CNS cell line, CAD, in which morphological differentiation is initiated by serum deprivation. 
  • Characterization of a gene trap insertion into a novel gene, cordon-bleu, expressed in axial structures of the gastrulating mouse embryo. 
  • Characterization of a human prostate adenocarcinoma cell line (DU 145) as a monolayer culture and as a solid tumor in athymic mice. 
  • Characterization of a monoclonal antibody (5E9) that defines a human cell surface antigen of cell activation. 
  • Characterization of a murine monoclonal antibody that mimics heparin-induced thrombocytopenia antibodies. 
  • Characterization of a novel human corneal endothelial antigen. 
  • Characterization of a rare IL-10-competent B-cell subset in humans that parallels mouse regulatory B10 cells. 
  • Characterization of a recovery global cerebral ischemia model in the mouse. 
  • Characterization of a spontaneous murine astrocytoma and abrogation of its tumorigenicity by cytokine secretion. 
  • Characterization of a thymus-tropic HIV-1 isolate from a rapid progressor: role of the envelope. 
  • Characterization of alpha 2-macroglobulin-plasmin complexes: complete subunit cleavage alters receptor recognition in vivo and in vitro. 
  • Characterization of an oxaliplatin sensitivity predictor in a preclinical murine model of colorectal cancer. 
  • Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice. 
  • Characterization of angiotensin II-receptor subtypes in podocytes. 
  • Characterization of angiotensin-converting enzyme 2 ectodomain shedding from mouse proximal tubular cells. 
  • Characterization of antibodies to canine renal renin. Studies of interspecies homology of renin using antibodies as probe. 
  • Characterization of antiestrogenic activity of the Chinese herb, prunella vulgaris, using in vitro and in vivo (Mouse Xenograft) models. 
  • Characterization of basal pseudopod-like processes in ileal and colonic PYY cells. 
  • Characterization of cDNA encoding mouse DNA repair protein O6-methylguanine-DNA methyltransferase and high-level expression of the wild-type and mutant proteins in Escherichia coli. 
  • Characterization of cDNAs encoding the polypyrimidine tract-binding protein. 
  • Characterization of conditioned place preference to cocaine in congenic dopamine transporter knockout female mice. 
  • Characterization of cord blood natural killer and lymphokine activated killer lymphocytes following ex vivo cellular engineering. 
  • Characterization of cytotoxic cells generated from in vitro cultures of murine bone marrow cells. 
  • Characterization of delayed neurotoxicity in the mouse following chronic oral administration of tri-o-cresyl phosphate. 
  • Characterization of delta opioid receptors in lung cancer using a novel nonpeptidic ligand. 
  • Characterization of effector T cells in dry eye disease. 
  • Characterization of elongation factor-1A (eEF1A-1) and eEF1A-2/S1 protein expression in normal and wasted mice. 
  • Characterization of functional human alpha 2-macroglobulin half-molecules isolated by limited reduction with dithiothreitol. 
  • Characterization of glomerular thromboxane receptors in murine lupus nephritis. 
  • Characterization of human CD7 transgenic mice. 
  • Characterization of insulin-like growth factor-binding protein-related proteins (IGFBP-rPs) 1, 2, and 3 in human prostate epithelial cells: potential roles for IGFBP-rP1 and 2 in senescence of the prostatic epithelium. 
  • Characterization of intraocular immunopathology following intracameral inoculation with alloantigen. 
  • Characterization of lens fiber cell triton insoluble fraction reveals ERM (ezrin, radixin, moesin) proteins as major cytoskeletal-associated proteins. 
  • Characterization of lung inflammation and its impact on macrophage function in aging. 
  • Characterization of mice deficient in the Src family nonreceptor tyrosine kinase Frk/rak. 
  • Characterization of moesin in the sea urchin Lytechinus variegatus: redistribution to the plasma membrane following fertilization is inhibited by cytochalasin B. 
  • Characterization of monoclonal antibodies with specificity for DNA and the synthetic polypeptide antigen (T,G)-A-L. 
  • Characterization of monolayer and organ cultures of cloned and enriched lymphohematopoietic stroma cell populations. 
  • Characterization of mouse embryonic cells deficient in the ctr1 high affinity copper transporter. Identification of a Ctr1-independent copper transport system. 
  • Characterization of murine BATF: a negative regulator of activator protein-1 activity in the thymus. 
  • Characterization of murine carcinoembryonic antigen gene family members. 
  • Characterization of murine peritoneal macrophage receptors for fibrin(ogen) degradation products. 
  • Characterization of nanoprobe uptake in single cells: spatial and temporal tracking via SERS labeling and modulation of surface charge. 
  • Characterization of neuronal/glial differentiation of murine adipose-derived adult stromal cells. 
  • Characterization of new gangliosides of the lactotetraose series in murine xenografts of a human glioma cell line. 
  • Characterization of nicotinic agonist-induced [(3)H]dopamine release from synaptosomes prepared from four mouse brain regions. 
  • Characterization of nonpathogenic, live, viral vaccine vectors inducing potent cellular immune responses. 
  • Characterization of potential precursor populations in the mouse olfactory epithelium using immunocytochemistry and autoradiography. 
  • Characterization of prostatic epithelial cell lines derived from transgenic adenocarcinoma of the mouse prostate (TRAMP) model. 
  • Characterization of senescence- and apoptosis-dependent forms of terminin as derived from a precursor found in replicating and nonreplicating cells. 
  • Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene. 
  • Characterization of subtle brain abnormalities in a mouse model of Hedgehog pathway antagonist-induced cleft lip and palate. 
  • Characterization of the antiabsence effects of SCH 50911, a GABA-B receptor antagonist, in the lethargic mouse, gamma-hydroxybutyrate, and pentylenetetrazole models. 
  • Characterization of the calcium response to thyrotropin-releasing hormone (TRH) in cells transfected with TRH receptor complementary DNA: importance of voltage-sensitive calcium channels. 
  • Characterization of the distinct orthotopic bone-forming activity of 14 BMPs using recombinant adenovirus-mediated gene delivery. 
  • Characterization of the effect of hyperthermia on nanoparticle extravasation from tumor vasculature. 
  • Characterization of the effects of endotoxin on macrophage tumor cell killing. 
  • Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts. 
  • Characterization of the immune response to the major glycoprotein (gp 71) of Friend leukemia virus. I. Response in BALB/c mice. 
  • Characterization of the immune response to the major glycoprotein (gp71) of Friend leukemia virus. II. Response in C57BL/6 mice. 
  • Characterization of the immune response to the major glycoprotein (gp71) of Friend leukemia virus. III. Influence on endogenous MuLV-mediated pathogenesis. 
  • Characterization of the insulinotropic potency of polyunsaturated fatty acids. 
  • Characterization of the mechanisms of busulfan resistance in a human glioblastoma multiforme xenograft. 
  • Characterization of the mouse FTZ-F1 gene, which encodes a key regulator of steroid hydroxylase gene expression. 
  • Characterization of the mouse SPARC/osteonectin gene. Intron/exon organization and an unusual promoter region. 
  • Characterization of the mouse transforming growth factor alpha gene: its expression during eyelid development and in waved 1 tissues. 
  • Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal. 
  • Characterization of the role of the amino-terminal proline in the enzymatic activity catalyzed by macrophage migration inhibitory factor. 
  • Characterization of the serum In(Lu)-related antigen: identification of a serum protein related to erythrocyte p80. 
  • Characterization of the tissue regression process in the uterus of older mice as apoptotic by the presence of Tp30, an isoform of terminin. 
  • Characterization of the trans-activation properties of equine herpesvirus 1 EICP0 protein. 
  • Characterization of the ubiquitin-modified proteome regulated by transient forebrain ischemia. 
  • Characterization of three restricted specificity monoclonal antibodies raised against the human glioma cell line D-54 MG. 
  • Characterization of topographical effects on macrophage behavior in a foreign body response model. 
  • Characterization of tumor-specific cytotoxic effector cells with a novel CD3-/Thy-1+ phenotype. 
  • Chemerin-activated functions of CMKLR1 are regulated by G protein-coupled receptor kinase 6 (GRK6) and β-arrestin 2 in inflammatory macrophages. 
  • Chemical and structural modifications of alpha 2-macroglobulin: effects on receptor binding and endocytosis studied in an in vivo model. 
  • Chemical evidence for early but unsustained growth in the obstructed mouse kidney. 
  • Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. 
  • Chemical interrogation of the malaria kinome. 
  • Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis. 
  • Chemical modification and site-directed mutagenesis of conserved HXXH and PP-loop motif arginines and histidines in the murine bifunctional ATP sulfurylase/adenosine 5'-phosphosulfate kinase. 
  • Chemical sintering generates uniform porous hyaluronic acid hydrogels. 
  • Chemical skin carcinogenesis is prevented in mice by the induced expression of a TGF-beta related transgene. 
  • Chemical structure of carbamoylating groups and their relationship to bone marrow toxicity and antiglioma activity of bifunctionally alkylating and carbamoylating nitrosoureas. 
  • Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis. 
  • Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2. 
  • Chemokines and B-cell homing to follicles. 
  • Chemoprevention of pancreatic cancer: ready for the clinic? 
  • Chemotactic factor and P15E-related chemotaxis inhibitor in human melanoma cell lines with different macrophage content and tumorigenicity in nude mice. 
  • Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor. 
  • Chemotherapy Induces Programmed Cell Death-Ligand 1 Overexpression via the Nuclear Factor-κB to Foster an Immunosuppressive Tumor Microenvironment in Ovarian Cancer. 
  • Chemotherapy and cancer stem cells. 
  • Chemotherapy and radiation therapy of human medulloblastoma in athymic nude mice. 
  • Chemotherapy of subcutaneous and intracranial human medulloblastoma xenografts in athymic nude mice. 
  • Chemotherapy-Induced Depletion of OCT4-Positive Cancer Stem Cells in a Mouse Model of Malignant Testicular Cancer. 
  • Chicken calmodulin promoter activity in proliferating and differentiated cells. 
  • Chikungunya virus nsP3 & nsP4 interacts with HSP-90 to promote virus replication: HSP-90 inhibitors reduce CHIKV infection and inflammation in vivo. 
  • Chimeric Sindbis/eastern equine encephalitis vaccine candidates are highly attenuated and immunogenic in mice. 
  • Chimeric alphavirus vaccine candidates for chikungunya. 
  • Chimeric anti-tenascin antibody 81C6: increased tumor localization compared with its murine parent. 
  • Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral vaccination in mice. 
  • Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. 
  • Chlamydia muridarum evades growth restriction by the IFN-gamma-inducible host resistance factor Irgb10. 
  • Chlamydia trachomatis Infection Leads to Defined Alterations to the Lipid Droplet Proteome in Epithelial Cells. 
  • Chlamydia trachomatis Is Resistant to Inclusion Ubiquitination and Associated Host Defense in Gamma Interferon-Primed Human Epithelial Cells. 
  • Chlamydial CT441 is a PDZ domain-containing tail-specific protease that interferes with the NF-kappaB pathway of immune response. 
  • Chloroform inhalation exposure conditions necessary to initiate liver toxicity in female B6C3F1 mice. 
  • Chloroquine improves survival and hematopoietic recovery after lethal low-dose-rate radiation. 
  • Chloroquine, quinine and quinidine inhibit calcium release from macrophage intracellular stores by blocking inositol 1,4,5-trisphosphate binding to its receptor. 
  • Cholecystokinin is not a peripheral satiety signal in the dog. 
  • Cholera toxin acts as a potent adjuvant for the induction of cytotoxic T-lymphocyte responses with non-replicating antigens. 
  • Cholera toxin and cell growth: role of membrane gangliosides. 
  • Choline availability during embryonic development alters the localization of calretinin in developing and aging mouse hippocampus. 
  • Cholinergic augmentation of insulin release requires ankyrin-B. 
  • Cholinergic mechanisms in pial vessels. Histochemistry, electron microscopy and pharmacology. 
  • Chondrogenic potential of adipose tissue-derived stromal cells in vitro and in vivo. 
  • Chondroprotective role of the osmotically sensitive ion channel transient receptor potential vanilloid 4: age- and sex-dependent progression of osteoarthritis in Trpv4-deficient mice. 
  • Chordin and noggin promote organizing centers of forebrain development in the mouse. 
  • Chordin is a modifier of tbx1 for the craniofacial malformations of 22q11 deletion syndrome phenotypes in mouse. 
  • Chromatin architecture, CCCTC-binding factor, and V(D)J recombination: managing long-distance relationships at antigen receptor loci. 
  • Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. 
  • Chromatin-related properties of CBP fused to MLL generate a myelodysplastic-like syndrome that evolves into myeloid leukemia. 
  • Chromium (VI) at plausible drinking water concentrations is not genotoxic in the in vivo bone marrow micronucleus or liver unscheduled DNA synthesis assays. 
  • Chromium(VI) induces p53-dependent apoptosis in diploid human lung and mouse dermal fibroblasts. 
  • Chromosomal assignment of the murine Gi alpha and Gs alpha genes. Implications for the obese mouse. 
  • Chromosomal assignments of the genes coding for human types II, III, and IV collagen: a dispersed gene family. 
  • Chromosomal basis of X chromosome inactivation: identification of a multigene domain in Xp11.21-p11.22 that escapes X inactivation. 
  • Chromosomal composition of malignant human gliomas through serial subcutaneous transplantation in athymic mice. 
  • Chromosomal localization of seven members of the murine TGF-beta superfamily suggests close linkage to several morphogenetic mutant loci. 
  • Chromosomal localization of the ankyrinG gene (ANK3/Ank3) to human 10q21 and mouse 10. 
  • Chromosomal localization of the human homeo box-containing genes, EN1 and EN2. 
  • Chromosomal localization of the mouse Src-like adapter protein (Slap) gene and its putative human homolog SLA. 
  • Chromosomal organization of adrenergic receptor genes. 
  • Chromosome mapping of human cell surface molecules: monoclonal anti-human lymphocyte antibodies 4F2, A3D8, and A1G3 define antigens controlled by different regions of chromosome 11. 
  • Chronic Ethanol Metabolism Inhibits Hepatic Mitochondrial Superoxide Dismutase via Lysine Acetylation. 
  • Chronic LPS inhalation causes emphysema-like changes in mouse lung that are associated with apoptosis. 
  • Chronic SSRI treatment exacerbates serotonin deficiency in humanized Tph2 mutant mice. 
  • Chronic activation of the kinase IKKβ impairs T cell function and survival. 
  • Chronic aspiration shifts the immune response from Th1 to Th2 in a murine model of asthma. 
  • Chronic aspiration shifts the immune response from adaptive immunity to innate immunity in a murine model of asthma. 
  • Chronic axial compression of the mouse tail segment induces MRI bone marrow edema changes that correlate with increased marrow vasculature and cellularity. 
  • Chronic dry eye disease is principally mediated by effector memory Th17 cells. 
  • Chronic elevation of calmodulin in the ventricles of transgenic mice increases the autonomous activity of calmodulin-dependent protein kinase II, which regulates atrial natriuretic factor gene expression. 
  • Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation. 
  • Chronic ethanol treatment increases expression of inhibitory G-proteins and reduces adenylylcyclase activity in the central nervous system of two lines of ethanol-sensitive mice. 
  • Chronic hepcidin induction causes hyposideremia and alters the pattern of cellular iron accumulation in hemochromatotic mice. 
  • Chronic in vivo multi-circuit neurophysiological recordings in mice. 
  • Chronic loss of noradrenergic tone produces β-arrestin2-mediated cocaine hypersensitivity and alters cellular D2 responses in the nucleus accumbens. 
  • Chronic lymphocytic leukemia and regulatory B cells share IL-10 competence and immunosuppressive function. 
  • Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration. 
  • Chronic rejection of mouse kidney allografts. 
  • Chronic treatment in vivo with β-adrenoceptor agonists induces dysfunction of airway β(2) -adrenoceptors and exacerbates lung inflammation in mice. 
  • Chronic wound repair and healing in older adults: current status and future research. 
  • Chronopharmacology of strychnine and allylglycine in the mouse. 
  • Cigarette smoke-related hydroquinone induces filamentous actin reorganization and heat shock protein 27 phosphorylation through p38 and extracellular signal-regulated kinase 1/2 in retinal pigment epithelium: implications for age-related macular degeneration. 
  • Cigarette smoke-related oxidants and the development of sub-RPE deposits in an experimental animal model of dry AMD. 
  • Cilia in vertebrate development and disease. 
  • Cilia loss sensitizes cells to transformation by activating the mevalonate pathway. 
  • Ciliary neurotrophic factor receptor alpha mRNA in NB41A3 neuroblastoma cells: regulation by cAMP. 
  • Ciliated epithelial cell lifespan in the mouse trachea and lung. 
  • Ciliopathy proteins regulate paracrine signaling by modulating proteasomal degradation of mediators. 
  • Circadian clock NAD+ cycle drives mitochondrial oxidative metabolism in mice. 
  • Circadian oscillation of gene expression in murine calvarial bone. 
  • Circadian rhythm in cerebral blood volume of mouse. 
  • Circadian rhythms of activity and drinking in mice lacking angiotensin II 1A receptors. 
  • Circuit-selective striatal synaptic dysfunction in the Sapap3 knockout mouse model of obsessive-compulsive disorder. 
  • Circular transcripts of the testis-determining gene Sry in adult mouse testis. 
  • Circulating Exosomes Induced by Cardiac Pressure Overload Contain Functional Angiotensin II Type 1 Receptors. 
  • Circulating and binding characteristics of wild-type factor IX and certain Gla domain mutants in vivo. 
  • Circumventing tamoxifen resistance in breast cancers using antiestrogens that induce unique conformational changes in the estrogen receptor. 
  • Cis-acting human ApoE tissue expression element is associated with human pattern of intraneuronal ApoE in transgenic mice. 
  • Cisplatin, BCNU, cyclophosphamide, and prednisone in multiple myeloma. 
  • Cl- and K+ transport in human biliary cell lines. 
  • Clara cell secretory protein and phospholipase A2 activity modulate acute ventilator-induced lung injury in mice. 
  • Clara cell secretory protein decreases lung inflammation after acute virus infection. 
  • Clara cell secretory protein deficiency alters clara cell secretory apparatus and the protein composition of airway lining fluid. 
  • Clara cell secretory protein deficiency increases oxidant stress response in conducting airways. 
  • Clara cell secretory protein-deficient mice differ from wild-type mice in inflammatory chemokine expression to oxygen and ozone, but not to endotoxin. 
  • Clara cell secretory protein-expressing cells of the airway neuroepithelial body microenvironment include a label-retaining subset and are critical for epithelial renewal after progenitor cell depletion. 
  • Clara cell secretory protein: a determinant of PCB bioaccumulation in mammals. 
  • Clara cells attenuate the inflammatory response through regulation of macrophage behavior. 
  • Class I restricted CTL recognition of a soluble protein delivered by liposomes containing lipophilic polylysines. 
  • Class IIb HDAC6 regulates endothelial cell migration and angiogenesis by deacetylation of cortactin. 
  • Classically conditioned enhancement of hyperinsulinemia in the ob/ob mouse. 
  • Classically conditioned hyperglycemia in the obese mouse. 
  • Clearance and binding of native and defucosylated lactoferrin. 
  • Clearance and binding of two electrophoretic "fast" forms of human alpha 2-macroglobulin. 
  • Clearance and distribution of recombinant murine gamma-interferon in mice. 
  • Clearance kinetics and matrix binding partners of the receptor for advanced glycation end products. 
  • Clearance of adenovirus-infected hepatocytes by MHC class I-restricted CD4+ CTLs in vivo. 
  • Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia. 
  • Clinical and preclinical translation of cell-based therapies using adipose tissue-derived cells. 
  • Clinical and serologic manifestations of autoimmune disease in MRL-lpr/lpr mice lacking nitric oxide synthase type 2. 
  • Clinical isolates of measles virus use CD46 as a cellular receptor. 
  • Clinical prospects for neural grafting therapy for hippocampal lesions and epilepsy. 
  • Clonal Evolution of Autoreactive Germinal Centers. 
  • Clonal contributions of small numbers of retrovirally marked hematopoietic stem cells engrafted in unirradiated neonatal W/Wv mice. 
  • Clonal deletion and clonal anergy in the thymus induced by cellular elements with different radiation sensitivities. 
  • Cloned endothelium derived from autoimmune vascular disease retain structural and functional characteristics of normal endothelial cells. 
  • Cloned mice have an obese phenotype not transmitted to their offspring. 
  • Cloning and characterization of ATRAP, a novel protein that interacts with the angiotensin II type 1 receptor. 
  • Cloning and characterization of a cAMP-specific cyclic nucleotide phosphodiesterase. 
  • Cloning and characterization of a mammalian lithium-sensitive bisphosphate 3'-nucleotidase inhibited by inositol 1,4-bisphosphate. 
  • Cloning and characterization of developmental endothelial locus-1: an embryonic endothelial cell protein that binds the alphavbeta3 integrin receptor. 
  • Cloning and characterization of three new murine genes encoding short homologues of RNase P RNA. 
  • Cloning and characterization of two human VIP1-like inositol hexakisphosphate and diphosphoinositol pentakisphosphate kinases. 
  • Cloning and molecular characterization of cGMP-gated ion channels from rod and cone photoreceptors of striped bass ( M. saxatilis ) retina. 
  • Cloning genes that encode inducible forms of P-450. 
  • Cloning of B cells from autoimmune MRL-lpr/lpr and MRL.xid mice. 
  • Cloning of a complementary DNA encoding a new mouse B lymphocyte differentiation antigen, homologous to the human B1 (CD20) antigen, and localization of the gene to chromosome 19. 
  • Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease. 
  • Cloning of cDNA and analysis of the gene for mouse angiotensin II type 2 receptor. 
  • Cloning of human and mouse brain cDNAs coding for S1, the second member of the mammalian elongation factor-1 alpha gene family: analysis of a possible evolutionary pathway. 
  • Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper discs. I. A description of the technique and of methods for the analysis of colonies. 
  • Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper discs. II. Paratope frequencies within the mitogen-selected repertoire. 
  • Cloning of mitogen- and antigen-reactive B lymphocytes on filter paper disks: phenotypic and genotypic analysis of B cell colonies. 
  • Cloning of murine splenic T lymphocytes and natural killer (NK) cells on filter paper discs: detection of a novel NK/T phenotype. 
  • Cloning of rat thymic stromal lymphopoietin receptor (TSLPR) and characterization of genomic structure of murine Tslpr gene. 
  • Cloning of the human glycine transporter type 1: molecular and pharmacological characterization of novel isoform variants and chromosomal localization of the gene in the human and mouse genomes. 
  • Cloning, characterization, and chromosomal localization of rec1.3, a member of the G-protein-coupled receptor family highly expressed in brain. 
  • Cloning, characterization, and expression of two angiotensin receptor (AT-1) isoforms from the mouse genome. 
  • Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family. 
  • Cloning, gene structure and genomic localization of an orphan transporter from mouse kidney with six alternatively-spliced isoforms. 
  • Cloning, heterologous expression, and chromosomal localization of human inositol polyphosphate 1-phosphatase. 
  • Cloning, pharmacological characterization, and genomic localization of the human creatine transporter. 
  • Close genetic and physical linkage between the murine haemopoietic growth factor genes GM-CSF and Multi-CSF (IL3). 
  • Closing the iron gate. 
  • Clozapine-, but not haloperidol-, induced increases in deltaFosB-like immunoreactivity are completely blocked in the striatum of mice lacking D3 dopamine receptors. 
  • Club cells surviving influenza A virus infection induce temporary nonspecific antiviral immunity. 
  • Clustered Arg-Gly-Asp peptides enhances tumor targeting of nonviral vectors. 
  • Clustered cancer cells show a distinct adhesion behavior from single cell form under physiological shear conditions. 
  • Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing protein CD26/dipeptidyl peptidase IV. 
  • Clustering of voltage-sensitive sodium channels on axons is independent of direct Schwann cell contact in the dystrophic mouse. 
  • Co-assembling peptides as defined matrices for endothelial cells. 
  • Co-delivery of antigen and IL-12 by Venezuelan equine encephalitis virus replicon particles enhances antigen-specific immune responses and antitumor effects. 
  • Co-expression of vimentin and cytokeratins in parietal endoderm cells of early mouse embryo. 
  • Co-immunization with multimeric scaffolds and DNA rapidly induces potent autologous HIV-1 neutralizing antibodies and CD8+ T cells. 
  • Co-regulation of nuclear respiratory factor-1 by NFkappaB and CREB links LPS-induced inflammation to mitochondrial biogenesis. 
  • Coactivation of liver receptor homologue-1 by peroxisome proliferator-activated receptor gamma coactivator-1alpha on aromatase promoter II and its inhibition by activated retinoid X receptor suggest a novel target for breast-specific antiestrogen therapy. 
  • Coadministration of IL-12 or IL-10 expression cassettes drives immune responses toward a Th1 phenotype. 
  • Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. 
  • Cocaine increases dopamine release by mobilization of a synapsin-dependent reserve pool. 
  • Cocaine mechanisms: enhanced cocaine, fluoxetine and nisoxetine place preferences following monoamine transporter deletions. 
  • Cocaine self-administration in dopamine-transporter knockout mice. 
  • Cocaine self-administration reduces excitatory responses in the mouse nucleus accumbens shell. 
  • Cocaine-conditioned locomotion in dopamine transporter, norepinephrine transporter and 5-HT transporter knockout mice. 
  • Codon usage optimization of HIV type 1 subtype C gag, pol, env, and nef genes: in vitro expression and immune responses in DNA-vaccinated mice. 
  • Coevolution of the major histocompatibility complex and the t-complex in the mouse. I. Generation and maintenance of high complementarity associations. 
  • Coevolution of the major histocompatibility complex and the t-complex in the mouse. II. Modification of response to sharing of histocompatibility antigens. 
  • Cognitive neuroscience of attention deficit hyperactivity disorder and hyperkinetic disorder. 
  • Cold-induced brain edema in mice. Involvement of extracellular superoxide dismutase and nitric oxide. 
  • Collaborative interactions between MEF-2 and Sp1 in muscle-specific gene regulation. 
  • Collaborative role of E2F transcriptional activity and G1 cyclindependent kinase activity in the induction of S phase. 
  • Collagen fibril diameters in arteries of mice. A comparison of manual and computer-aided morphometric analyses. 
  • Collagenase 1 and collagenase 3 expression in a guinea pig model of osteoarthritis. 
  • Collapsing glomerulopathy: an inflammatory podocytopathy? 
  • Colloidal gold fluorescent microspheres: a new retrograde marker visualized by light and electron microscopy. 
  • Colonial morphology of staphylococci on Memphis agar: phase variation of slime production, resistance to beta-lactam antibiotics, and virulence. 
  • Colonoscopic injection for murine solid cecal cancer model. 
  • Colonoscopy-based colorectal cancer modeling in mice with CRISPR-Cas9 genome editing and organoid transplantation. 
  • Colorectal cancer models for novel drug discovery. 
  • Combination PI3K/MEK inhibition promotes tumor apoptosis and regression in PIK3CA wild-type, KRAS mutant colorectal cancer. 
  • Combination Therapy with NHS-muIL12 and Avelumab (anti-PD-L1) Enhances Antitumor Efficacy in Preclinical Cancer Models. 
  • Combination anti-CD2 and anti-CD3 monoclonal antibodies induce tolerance while altering interleukin-2, interleukin-4, tumor necrosis factor, and transforming growth factor-beta production. 
  • Combination immunotherapy with clinical-scale enriched human gammadelta T cells, hu14.18 antibody, and the immunocytokine Fc-IL7 in disseminated neuroblastoma. 
  • Combination induction therapy with monoclonal antibodies specific for CD80, CD86, and CD154 in nonhuman primate renal transplantation. 
  • Combination of ERK and autophagy inhibition as a treatment approach for pancreatic cancer. 
  • Combination testing (Stage 2) of the Anti-IGF-1 receptor antibody IMC-A12 with rapamycin by the pediatric preclinical testing program. 
  • Combination testing of cediranib (AZD2171) against childhood cancer models by the pediatric preclinical testing program. 
  • Combination therapy of inhibitors of epidermal growth factor receptor/vascular endothelial growth factor receptor 2 (AEE788) and the mammalian target of rapamycin (RAD001) offers improved glioblastoma tumor growth inhibition. 
  • Combination treatment of murine tumors by adenovirus-mediated local B7/IL12 immunotherapy and radiotherapy. 
  • Combination versus single agent therapy in effecting complete therapeutic response in human bladder cancer: analysis of cisplatin and/or 5-fluorouracil in an in vivo survival model. 
  • Combined activity of amphotericin B and 5-fluorocytosine against Cryptococcus neoformans in vitro and in vivo in mice. 
  • Combined aerobic exercise and enzyme replacement therapy rejuvenates the mitochondrial-lysosomal axis and alleviates autophagic blockage in Pompe disease. 
  • Combined bone morphogenetic protein-2 and -7 gene transfer enhances osteoblastic differentiation and spine fusion in a rodent model. 
  • Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansion. 
  • Combined exposure to nicotine and ethanol in adolescent mice differentially affects memory and learning during exposure and withdrawal. 
  • Combined hyperspectral and spectral domain optical coherence tomography microscope for noninvasive hemodynamic imaging. 
  • Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice. 
  • Combined treatment with acupuncture reduces effective dose and alleviates adverse effect of L-dopa by normalizing Parkinson's disease-induced neurochemical imbalance. 
  • Combining PARP-1 inhibition and radiation in Ewing sarcoma results in lethal DNA damage. 
  • Comments about Joint Modeling of Cluster Size and Binary and Continuous Subunit-Specific Outcomes. 
  • Comments on Point:Counterpoint: The dominant contributor to systemic hypertension: Chronic activation of the sympathetic nervous system vs. Activation of the intrarenal renin-angiotensin system. AT1 receptors in the kidney mediate the chronic hypertensive response to angiotensin II. 
  • Commissioning a small-field biological irradiator using point, 2D, and 3D dosimetry techniques. 
  • Commitment to cell death is signaled by the appearance of a terminin protein of 30 kDa. 
  • Common commercial and consumer products contain activators of the aryl hydrocarbon (dioxin) receptor. 
  • Common human ANK2 variant confers in vivo arrhythmia phenotypes. 
  • Common promoter elements in odorant and vomeronasal receptor genes. 
  • Common tolerance mechanisms, but distinct cross-reactivities associated with gp41 and lipids, limit production of HIV-1 broad neutralizing antibodies 2F5 and 4E10. 
  • Comparative analysis of antigen loading strategies of dendritic cells for tumor immunotherapy. 
  • Comparative analysis of the zeta-crystallin/quinone reductase gene in guinea pig and mouse. 
  • Comparative and functional evaluation of in vitro generated to ex vivo CD8 T cells. 
  • Comparative effects of thermosensitive doxorubicin-containing liposomes and hyperthermia in human and murine tumours. 
  • Comparative efficacy evaluation of dicationic carbazole compounds, nitazoxanide, and paromomycin against Cryptosporidium parvum infections in a neonatal mouse model. 
  • Comparative evaluation of a new magnetic bead-based DNA extraction method from fecal samples for downstream next-generation 16S rRNA gene sequencing. 
  • Comparative genomics identifies a flagellar and basal body proteome that includes the BBS5 human disease gene. 
  • Comparative genomics search for losses of long-established genes on the human lineage. 
  • Comparative immunogenicity of HIV-1 gp160, gp140 and gp120 expressed by live attenuated newcastle disease virus vector. 
  • Comparative incorporation of P32 into lung phosphatidyl choline in mammals with different metabolic and pulmonary morphologic characteristics. 
  • Comparative localization of glioma-reactive monoclonal antibodies in vivo in an athymic mouse human glioma xenograft model. 
  • Comparative localization of murine monoclonal antibody Me1-14 F(ab')2 fragment and whole IgG2a in human glioma xenografts. 
  • Comparative pathogenesis of clinical and nonclinical isolates of Saccharomyces cerevisiae. 
  • Comparative pharmacodynamics of keliximab and clenoliximab in transgenic mice bearing human CD4. 
  • Comparative physical and transcript maps of approximately 1 Mb around loop-tail, a gene for severe neural tube defects on distal mouse chromosome 1 and human chromosome 1q22-q23. 
  • Comparative proteomic analysis of cell cycle-dependent apoptosis induced by transforming growth factor-beta. 
  • Comparative proteomic analysis of proteins involved in cell aggregation during neural differentiation of P19 mouse embryonic carcinoma cells. 
  • Comparative stereology of mouse atria. 
  • Comparative stereology of the lizard and frog myocardium. 
  • Comparative stereology of the mouse and finch left ventricle. 
  • Comparative tissue distribution in mice of the alpha-emitter 211At and 131I as labels of a monoclonal antibody and F(ab')2 fragment. 
  • Comparative toxicity of C60 aggregates toward mammalian cells: role of tetrahydrofuran (THF) decomposition. 
  • Comparative vibration levels perceived among species in a laboratory animal facility. 
  • Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker. 
  • Comparing in vivo pump-probe and multiphoton fluorescence microscopy of melanoma and pigmented lesions. 
  • Comparison of 4D-microSPECT and microCT for murine cardiac function. 
  • Comparison of [18 F]fluorocholine and [18 F]fluorodeoxyglucose for positron emission tomography of androgen dependent and androgen independent prostate cancer. 
  • Comparison of fecal biota from specific pathogen free and feral mice. 
  • Comparison of in vitro and in vivo differentiation of myeloblastic leukemia of the RFM/Un mouse. 
  • Comparison of in vivo efficacy and mechanism of action of antimurine monoclonal antibodies directed against TCR alpha beta (H57-597) and CD3 (145-2C11). 
  • Comparison of interval timing behaviour in mice following dorsal or ventral hippocampal lesions with mice having δ-opioid receptor gene deletion. 
  • Comparison of intradermal and intramuscular delivery followed by in vivo electroporation of SIV Env DNA in macaques. 
  • Comparison of monoclonal antibody delivery to intracranial glioma xenografts by intravenous and intracarotid administration. 
  • Comparison of multiple enzyme activatable near-infrared fluorescent molecular probes for detection and quantification of inflammation in murine colitis models. 
  • Comparison of multiple vaccine vectors in a single heterologous prime-boost trial. 
  • Comparison of pattern detection methods in microarray time series of the segmentation clock. 
  • Comparison of pleural responses of rats and hamsters to subchronic inhalation of refractory ceramic fibers. 
  • Comparison of the Hypoxia PET Tracer (18)F-EF5 to Immunohistochemical Marker EF5 in 3 Different Human Tumor Xenograft Models. 
  • Comparison of the abilities of ambient and manufactured nanoparticles to induce cellular toxicity according to an oxidative stress paradigm. 
  • Comparison of the effects of IL-1 alpha and TNF-alpha on phagocyte accumulation and murine antibacterial immunity. 
  • Comparison of the effects of hydralazine on tumor and normal tissue blood perfusion by MRI. 
  • Comparison of the expression of three highly related genes, Fgf8, Fgf17 and Fgf18, in the mouse embryo. 
  • Comparison of the genomes of the wild-type French viscerotropic strain of yellow fever virus with its vaccine derivative French neurotropic vaccine. 
  • Comparison of the roles of calcineurin in physiology and virulence in serotype D and serotype A strains of Cryptococcus neoformans. 
  • Comparison of thymocyte development and cytokine production in CD7-deficient, CD28-deficient and CD7/CD28 double-deficient mice. 
  • Comparison of topical dry eye medications for the treatment of keratoconjunctivitis sicca in a botulinum toxin B-induced mouse model. 
  • Comparison of tumor and normal tissue oxygen tension measurements using OxyLite or microelectrodes in rodents. 
  • Compensation and specificity of function within the E2F family. 
  • Compensatory T cell responses in IRG-deficient mice prevent sustained Chlamydia trachomatis infections. 
  • Compensatory renal growth after unilateral ureteral obstruction. 
  • Competing Actions of Type 1 Angiotensin II Receptors Expressed on T Lymphocytes and Kidney Epithelium during Cisplatin-Induced AKI. 
  • Competitive displacement of phosphoinositide 3-kinase from beta-adrenergic receptor kinase-1 improves postinfarction adverse myocardial remodeling. 
  • Complement C4 inhibits systemic autoimmunity through a mechanism independent of complement receptors CR1 and CR2. 
  • Complement Factor H Inhibits CD47-Mediated Resolution of Inflammation. 
  • Complement activation contributes to perioperative neurocognitive disorders in mice. 
  • Complement and arthritis: another step in understanding. 
  • Complement component C3d-antigen complexes can either augment or inhibit B lymphocyte activation and humoral immunity in mice depending on the degree of CD21/CD19 complex engagement. 
  • Complement levels and activity in the normal and LPS-injured lung. 
  • Complement receptors CD21/35 link innate and protective immunity during Streptococcus pneumoniae infection by regulating IgG3 antibody responses. 
  • Complementary Roles of GADD34- and CReP-Containing Eukaryotic Initiation Factor 2α Phosphatases during the Unfolded Protein Response. 
  • Complementary codes for odor identity and intensity in olfactory cortex. 
  • Complementary roles for CD19 and Bruton's tyrosine kinase in B lymphocyte signal transduction. 
  • Complete correction of hyperphenylalaninemia following liver-directed, recombinant AAV2/8 vector-mediated gene therapy in murine phenylketonuria. 
  • Complete functional mapping of infection- and vaccine-elicited antibodies against the fusion peptide of HIV. 
  • Complex Antigens Drive Permissive Clonal Selection in Germinal Centers. 
  • Complex modular cis-acting elements regulate expression of the cardiac specifying homeobox gene Csx/Nkx2.5. 
  • Complex role of the vitamin D receptor and its ligand in adipogenesis in 3T3-L1 cells. 
  • Complexes between serpins and inactive proteinases are not thermodynamically stable but are recognized by serpin receptors. 
  • Complexity of CNC transcription factors as revealed by gene targeting of the Nrf3 locus. 
  • Composite primary neuronal high-content screening assay for Huntington's disease incorporating non-cell-autonomous interactions. 
  • Compounds from Sichuan and Melegueta peppers activate, covalently and non-covalently, TRPA1 and TRPV1 channels. 
  • Comprehensive characterization and optimization of anti-LRRK2 (leucine-rich repeat kinase 2) monoclonal antibodies. 
  • Comprehensive metabolic modeling of multiple 13C-isotopomer data sets to study metabolism in perfused working hearts. 
  • Comprehensive microRNA analysis in bleomycin-induced pulmonary fibrosis identifies multiple sites of molecular regulation. 
  • Comprehensive models of human primary and metastatic colorectal tumors in immunodeficient and immunocompetent mice by chemokine targeting. 
  • Comprehensive pharmacokinetic studies and oral bioavailability of two Mn porphyrin-based SOD mimics, MnTE-2-PyP5+ and MnTnHex-2-PyP5+. 
  • Compressive properties of mouse articular cartilage determined in a novel micro-indentation test method and biphasic finite element model. 
  • Compromised HOXA5 function can limit p53 expression in human breast tumours. 
  • Computational and experimental analyses reveal previously undetected coding exons of the KRIT1 (CCM1) gene. 
  • Computational multiscale toxicodynamic modeling of silver and carbon nanoparticle effects on mouse lung function. 
  • Computational tools for understanding sequence variability in recombination signals. 
  • Computed tomography imaging of primary lung cancer in mice using a liposomal-iodinated contrast agent. 
  • Comt1 genotype and expression predicts anxiety and nociceptive sensitivity in inbred strains of mice. 
  • Concentrated RD114-pseudotyped MFGS-gp91phox vector achieves high levels of functional correction of the chronic granulomatous disease oxidase defect in NOD/SCID/beta -microglobulin-/- repopulating mobilized human peripheral blood CD34+ cells. 
  • Concepts and challenges in cancer risk prediction for the space radiation environment. 
  • Concerted regulation of skeletal muscle contractility by oxygen tension and endogenous nitric oxide. 
  • Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. 
  • Concurrent administration of coenzyme Q10 and alpha-tocopherol improves learning in aged mice. 
  • Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro. 
  • Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence. 
  • Conditional MLL-CBP targets GMP and models therapy-related myeloproliferative disease. 
  • Conditional Macrophage Depletion Increases Inflammation and Does Not Inhibit the Development of Osteoarthritis in Obese Macrophage Fas-Induced Apoptosis-Transgenic Mice. 
  • Conditional calcineurin knockout mice exhibit multiple abnormal behaviors related to schizophrenia. 
  • Conditional clara cell ablation reveals a self-renewing progenitor function of pulmonary neuroendocrine cells. 
  • Conditional deletion of TrkB but not BDNF prevents epileptogenesis in the kindling model. 
  • Conditional deletion of TrkC does not modify limbic epileptogenesis. 
  • Conditional expression in corticothalamic efferents reveals a developmental role for nicotinic acetylcholine receptors in modulation of passive avoidance behavior. 
  • Conditional expression of SV40 T-antigen in mouse cardiomyocytes facilitates an inducible switch from proliferation to differentiation. 
  • Conditional expression of the mutant Ki-rasG12C allele results in formation of benign lung adenomas: development of a novel mouse lung tumor model. 
  • Conditional gene silencing in mammalian cells mediated by a stress-inducible promoter. 
  • Conditional knockout of Fgf13 in murine hearts increases arrhythmia susceptibility and reveals novel ion channel modulatory roles. 
  • Conditional stabilization of beta-catenin expands the pool of lung stem cells. 
  • Conditional targeting of E-cadherin in skin: insights into hyperproliferative and degenerative responses. 
  • Conditional telomerase induction causes proliferation of hair follicle stem cells. 
  • Conditions for an in vitro culture of murine mixed hematopoietic colonies and their putative cellular origin. 
  • Conditions that promote primary human skeletal myoblast culture and muscle differentiation in vitro. 
  • Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. 
  • Congenital brain serotonin deficiency leads to reduced ethanol sensitivity and increased ethanol consumption in mice. 
  • Congenital polycystic kidney disease. Genetically transmitted infantile polycystic kidney disease in C57BL/6J mice. 
  • Connexin 36 and rod bipolar cell independent rod pathways drive retinal ganglion cells and optokinetic reflexes. 
  • Connexin-43 induces chemokine release from spinal cord astrocytes to maintain late-phase neuropathic pain in mice. 
  • Consensus report of the national cancer institute clinical trials planning meeting on pancreas cancer treatment. 
  • Consequences of intra-articular bleeding in haemophilia: science to clinical practice and beyond. 
  • Conservation of a stress response: human heat shock transcription factors functionally substitute for yeast HSF. 
  • Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. 
  • Conserved Residues Control Activation of Mammalian G Protein-Coupled Odorant Receptors. 
  • Conserved action of β-catenin during female fate determination in the red-eared slider turtle. 
  • Conserved cryptic recombination signals in Vkappa gene segments are cleaved in small pre-B cells. 
  • Conserved cryptic recombination signals in Vkappa gene segments are cleaved in small pre-B cells. 
  • Consistent deregulation of gene expression between human and murine MLL rearrangement leukemias. 
  • Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals. 
  • Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence. 
  • Constitutive activation of the aromatic hydrocarbon receptor. 
  • Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. 
  • Constitutive cytokine mRNAs mark natural killer (NK) and NK T cells poised for rapid effector function. 
  • Constitutive hedgehog signaling in chondrosarcoma up-regulates tumor cell proliferation. 
  • Constitutive hepcidin expression prevents iron overload in a mouse model of hemochromatosis. 
  • Constitutively activated STAT3 frequently coexpresses with epidermal growth factor receptor in high-grade gliomas and targeting STAT3 sensitizes them to Iressa and alkylators. 
  • Construction and screening of a genomic library specific for mouse chromosome 16. 
  • Construction of a global pain systems network highlights phospholipid signaling as a regulator of heat nociception. 
  • Construction of low-variability litters of preweaning mice. 
  • Construction of modular circuits in the mammalian brain. 
  • Construction, imaging, and analysis of FRET-based tension sensors in living cells. 
  • Contained indirect viable-cell membrane immunofluorescence microassay for surface antigen analysis of cells infected with hazardous viruses. 
  • Contamination with E1A-positive wild-type adenovirus accounts for species-specific stimulation of islet cell proliferation by CCK: a cautionary note. 
  • Context-specific effects of fibulin-5 (DANCE/EVEC) on cell proliferation, motility, and invasion. Fibulin-5 is induced by transforming growth factor-beta and affects protein kinase cascades. 
  • Continuous administration of the three thrombospondin-1 type 1 repeats recombinant protein improves the potency of therapy in an orthotopic human pancreatic cancer model. 
  • Contrast-enhanced in vivo magnetic resonance microscopy of the mouse brain enabled by noninvasive opening of the blood-brain barrier with ultrasound. 
  • Contrasting response of lung parenchymal cells to instilled TNF alpha and IFN gamma: the inducibility of specific cell ICAM-1 in vivo. 
  • Contribution of IL-13 to early exocrinopathy in Id3-/- mice. 
  • Contribution of a 28-kilodalton membrane protein to the virulence of Haemophilus influenzae. 
  • Contribution of cell surface hydrophobicity protein 1 (Csh1p) to virulence of hydrophobic Candida albicans serotype A cells. 
  • Contribution of mast cells to bacterial clearance and their proliferation during experimental cystitis induced by type 1 fimbriated E. coli. 
  • Contribution of the VH11 gene family to mitogen-responsive B cell repertoire in C57BL/6 mice. 
  • Contributions of beta2-microglobulin-dependent molecules and lymphocytes to iron regulation: insights from HfeRag1(-/-) and beta2mRag1(-/-) double knock-out mice. 
  • Contributions of endothelial and neuronal nitric oxide synthases to cerebrovascular responses to hyperoxia. 
  • Contributions of mast cells and vasoactive products, leukotrienes and chymase, to dengue virus-induced vascular leakage. 
  • Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects. 
  • Control idiotope expression by monoclonal anti-idiotope antibodies. 
  • Control of CD4 gene expression: connecting signals to outcomes in T cell development. 
  • Control of IFN-alphaA by CD73: implications for mucosal inflammation. 
  • Control of IFN-gamma-mediated host resistance to intracellular pathogens by immunity-related GTPases (p47 GTPases). 
  • Control of Intestinal Inflammation, Colitis-Associated Tumorigenesis, and Macrophage Polarization by Fibrinogen-Like Protein 2. 
  • Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability. 
  • Control of RhoA methylation by carboxylesterase I. 
  • Control of axonal growth and regeneration of sensory neurons by the p110delta PI 3-kinase. 
  • Control of basement membrane remodeling and epithelial branching morphogenesis in embryonic lung by Rho and cytoskeletal tension. 
  • Control of cyclin B1 localization through regulated binding of the nuclear export factor CRM1. 
  • Control of embryonic lung branching morphogenesis by the Rho activator, cytotoxic necrotizing factor 1. 
  • Control of excitatory CNS synaptogenesis by astrocyte-secreted proteins Hevin and SPARC. 
  • Control of expression of insulin resistance and hyperglycemia by different genetic factors in diabetic C57BL/6J mice. 
  • Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1. 
  • Control of idiotope expression by monoclonal anti-idiotope and idiotope-bearing antibody. 
  • Control of liver and brain aromatic amino-acid metabolism by phenylalanine hydroxylase. 
  • Control of lymphocyte differentiation by the LEF-1/TCF family of transcription factors. 
  • Control of mammalian circadian rhythm by CKIepsilon-regulated proteasome-mediated PER2 degradation. 
  • Control of mitotic exit by PP2A regulation of Cdc25C and Cdk1. 
  • Control of myocardial contractile function by the level of beta-adrenergic receptor kinase 1 in gene-targeted mice. 
  • Control of neuronal precursor proliferation in the cerebellum by Sonic Hedgehog. 
  • Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3. 
  • Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR. 
  • Controlled and cardiac-restricted overexpression of the arginine vasopressin V1A receptor causes reversible left ventricular dysfunction through Gαq-mediated cell signaling. 
  • Controlled local delivery of interleukin-2 by biodegradable polymers protects animals from experimental brain tumors and liver tumors. 
  • Controlled release from fibers of polyelectrolyte complexes. 
  • Controlled release of heparin from poly(epsilon-caprolactone) electrospun fibers. 
  • Controlled release, biodegradable cytokine depots: a new approach in cancer vaccine design. 
  • Conventional B cells, not B-1 cells, are responsible for producing autoantibodies in lpr mice. 
  • Convergence of G protein-coupled receptor and S-nitrosylation signaling determines the outcome to cardiac ischemic injury. 
  • Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling. 
  • Convergence of bladder and colon sensory innervation occurs at the primary afferent level. 
  • Convergence of oncogenic and hormone receptor pathways promotes metastatic phenotypes. 
  • Convergence of presenilin- and tau-mediated pathways on axonal trafficking and neuronal function. 
  • Convergent and divergent evolution of genomic imprinting in the marsupial Monodelphis domestica. 
  • Convergent differential regulation of SLIT-ROBO axon guidance genes in the brains of vocal learners. 
  • Convergent effects of mouse Pet-1 deletion and human PET-1 variation on amygdala fear and threat processing. 
  • Convergent effects on cell signaling mechanisms mediate the actions of different neurobehavioral teratogens: alterations in cholinergic regulation of protein kinase C in chick and avian models. 
  • Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. 
  • Conversion of diploidy to haploidy. 
  • Cooperation among multiple transcription factors is required for access to minimal T-cell receptor alpha-enhancer chromatin in vivo. 
  • Cooperation between core binding factor and adjacent promoter elements contributes to the tissue-specific expression of interleukin-3. 
  • Cooperative transcription activation by Nurr1 and Pitx3 induces embryonic stem cell maturation to the midbrain dopamine neuron phenotype. 
  • Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3. 
  • Cooperativity between the phosphorylation of Thr95 and Ser77 of NHERF-1 in the hormonal regulation of renal phosphate transport. 
  • Coordinate regulation of forskolin-induced cellular proliferation in macrophages by protein kinase A/cAMP-response element-binding protein (CREB) and Epac1-Rap1 signaling: effects of silencing CREB gene expression on Akt activation. 
  • Coordinate regulation of mRNAs from multiple calmodulin genes during myoblast differentiation in vitro. 
  • Coordinate regulation of the alpha(2)-macroglobulin signaling receptor and the low density lipoprotein receptor-related protein/alpha(2)-macroglobulin receptor by insulin. 
  • Coordinated cerebellar climbing fiber activity signals learned sensorimotor predictions. 
  • Coordinated genome-wide modifications within proximal promoter cis-regulatory elements during vertebrate evolution. 
  • Coordinated loading of IRG resistance GTPases on to the Toxoplasma gondii parasitophorous vacuole. 
  • Copper is required for oncogenic BRAF signalling and tumorigenesis. 
  • Cord blood and bone marrow transplantation in inherited metabolic diseases: scientific basis, current status and future directions. 
  • Cordon-bleu is a conserved gene involved in neural tube formation. 
  • Cordon-bleu is an actin nucleation factor and controls neuronal morphology. 
  • Coreceptor signal strength regulates positive selection but does not determine CD4/CD8 lineage choice in a physiologic in vivo model. 
  • Corneal penetration of topical and subconjunctival bevacizumab. 
  • Correction of aberrant splicing of the cystic fibrosis transmembrane conductance regulator (CFTR) gene by antisense oligonucleotides. 
  • Correction of dystrophin expression in cells from Duchenne muscular dystrophy patients through genomic excision of exon 51 by zinc finger nucleases. 
  • Correction of glycogen storage disease type II by an adeno-associated virus vector containing a muscle-specific promoter. 
  • Correction of multiple striated muscles in murine Pompe disease through adeno-associated virus-mediated gene therapy. 
  • Correction of proliferative responses in purine nucleoside phosphorylase (PNP)-deficient T lymphocytes by retroviral-mediated PNP gene transfer and expression. 
  • Correction of sickle cell disease in transgenic mouse models by gene therapy. 
  • Correction: Mouse Models of Diet-Induced Nonalcoholic Steatohepatitis Reproduce the Heterogeneity of the Human Disease. 
  • Correlating notch signaling with thymocyte maturation. 
  • Correlation between varying levels of PMP22 expression and the degree of demyelination and reduction in nerve conduction velocity in transgenic mice. 
  • Correlation of DNA fragmentation and chromatin condensation in apoptotic nuclei of the Ser 6 mouse retina. 
  • Correlation of expression of bombesin-like peptides and receptors with growth inhibition by an anti-bombesin antibody in small-cell lung cancer cell lines. 
  • Correlation of total and interstrand DNA adducts in tumor and kidney with antitumor efficacies and differential nephrotoxicities of cis-ammine/cyclohexylamine-dichloroplatinum(II) and cisplatin. 
  • Correlative Confocal and 3D Electron Microscopy of a Specific Sensory Cell. 
  • Correspondence re: Geradts J, Wilentz RE, Roberts H. Immunohistochemical detection of the alternate ink4a-encoded tumor suppressor protein p14(arf) in archival human cancers and cell lines using commercial antibodies: correlation with p16(ink4a) expression. Mod pathol 2001;14:1162-68. 
  • Cortical control of affective networks. 
  • Cortical inhibition modified by embryonic neural precursors grafted into the postnatal brain. 
  • Cortical plasticity induced by inhibitory neuron transplantation. 
  • Cortical-amygdalar circuit dysfunction in a genetic mouse model of serotonin deficiency. 
  • Cortico-cortical projections in mouse visual cortex are functionally target specific. 
  • Cortico-striatal synaptic defects and OCD-like behaviours in Sapap3-mutant mice. 
  • Corticorelin acetate, a synthetic corticotropin-releasing factor with preclinical antitumor activity, alone and with bevacizumab, against human brain tumor models. 
  • Corticosteroids in brain tissue. 
  • Costimulation of adenylyl cyclase and phospholipase C by a mutant alpha 1B-adrenergic receptor transgene promotes malignant transformation of thyroid follicular cells. 
  • Costimulator dependence of lymphokine secretion by naive and activated CD4+ T lymphocytes from TCR transgenic mice. 
  • Counteracting signaling activities in lipid rafts associated with the invasion of lung epithelial cells by Pseudomonas aeruginosa. 
  • Countercurrent multiplication may not explain the axial osmolality gradient in the outer medulla of the rat kidney. 
  • Coupling of COX-1 to mPGES1 for prostaglandin E2 biosynthesis in the murine mammary gland. 
  • Coupling of beta2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. 
  • Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system. 
  • Covalent complexes of antigen and alpha(2)-macroglobulin: evidence for dramatically-increased immunogenicity. 
  • Covalent immobilization of stem cell factor and stromal derived factor 1α for in vitro culture of hematopoietic progenitor cells. 
  • Covalently immobilized platelet-derived growth factor-BB promotes angiogenesis in biomimetic poly(ethylene glycol) hydrogels. 
  • Cowpox virus genome encodes a second soluble homologue of cellular TNF receptors, distinct from CrmB, that binds TNF but not LT alpha. 
  • Cowpox virus induces interleukin-10 both in vitro and in vivo. 
  • Cp/Heph mutant mice have iron-induced neurodegeneration diminished by deferiprone. 
  • Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain. 
  • Creatine and cyclocreatine attenuate MPTP neurotoxicity. 
  • Creatine kinase activity as an indicator of unopposed estrogen action in the mouse uterus associated with anti-progesterone treatment. 
  • Creation of human tumour cells with defined genetic elements. 
  • Critical role for mouse marginal zone B cells in PF4/heparin antibody production. 
  • Critical role for the alpha-1B adrenergic receptor at the sympathetic neuroeffector junction. 
  • Critical role for the chemokine receptor CXCR6 in NK cell-mediated antigen-specific memory of haptens and viruses. 
  • Critical role of NOD2 in regulating the immune response to Staphylococcus aureus. 
  • Critical role of TNF-α in cerebral aneurysm formation and progression to rupture. 
  • Critical role of the tumor suppressor tuberous sclerosis complex 1 in dendritic cell activation of CD4 T cells by promoting MHC class II expression via IRF4 and CIITA. 
  • Critical roles of RasGRP1 for invariant NKT cell development. 
  • Critical roles of mTOR Complex 1 and 2 for T follicular helper cell differentiation and germinal center responses. 
  • Cross species genomic analysis identifies a mouse model as undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma. 
  • Cross-reacting antigens on L5178Y cells which serve as targets for cytotoxic T-lymphocyte lysis during establishment of the tumor dormant state. 
  • Cross-reactions of virally and chemically induced mouse sarcomas: surface expression of a common viral antigen. 
  • Cross-reactive monoclonal antibodies to multiple HIV-1 subtype and SIVcpz envelope glycoproteins. 
  • Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer. 
  • Cross-species analysis of genetically engineered mouse models of MAPK-driven colorectal cancer identifies hallmarks of the human disease. 
  • Cross-subtype T-cell immune responses induced by a human immunodeficiency virus type 1 group m consensus env immunogen. 
  • Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice. 
  • Crosslinked hyaluronic acid hydrogels: a strategy to functionalize and pattern. 
  • Crosstransplantation of kidneys in normal and Hyp mice. Evidence that the Hyp mouse phenotype is unrelated to an intrinsic renal defect. 
  • Crucial role for the VWF A1 domain in binding to type IV collagen. 
  • Crucial role of copper in detection of metal-coordinating odorants. 
  • Cryo-electron microscopy of biological samples. 
  • Cryptococcal cell morphology affects host cell interactions and pathogenicity. 
  • Cryptococcal titan cell formation is regulated by G-protein signaling in response to multiple stimuli. 
  • Cryptococcosis. 
  • Cryptococcus gattii VGIII isolates causing infections in HIV/AIDS patients in Southern California: identification of the local environmental source as arboreal. 
  • Cryptococcus neoformans Ilv2p confers resistance to sulfometuron methyl and is required for survival at 37 degrees C and in vivo. 
  • Cryptococcus neoformans Iron-Sulfur Protein Biogenesis Machinery Is a Novel Layer of Protection against Cu Stress. 
  • Cryptococcus neoformans Kin1 protein kinase homologue, identified through a Caenorhabditis elegans screen, promotes virulence in mammals. 
  • Cryptococcus neoformans Rim101 is associated with cell wall remodeling and evasion of the host immune responses. 
  • Cryptococcus neoformans copper detoxification machinery is critical for fungal virulence. 
  • Cryptococcus neoformans gene expression during murine macrophage infection. 
  • Cryptococcus neoformans gene involved in mammalian pathogenesis identified by a Caenorhabditis elegans progeny-based approach. 
  • Cryptococcus neoformans hyperfilamentous strain is hypervirulent in a murine model of cryptococcal meningoencephalitis. 
  • Cryptococcus neoformans is resistant to surfactant protein A mediated host defense mechanisms. 
  • Cryptococcus neoformans methionine synthase: expression analysis and requirement for virulence. 
  • Cryptococcus neoformans mitochondrial superoxide dismutase: an essential link between antioxidant function and high-temperature growth. 
  • Cryptococcus neoformans requires a functional glycolytic pathway for disease but not persistence in the host. 
  • Cryptococcus neoformans strains and infection in apparently immunocompetent patients, China. 
  • Cryptococcus neoformans {alpha} strains preferentially disseminate to the central nervous system during coinfection. 
  • Cryptococcus neoformans: a sugar-coated killer with designer genes. 
  • Crystal structure of the major histocompatibility complex class I H-2Kb molecule containing a single viral peptide: implications for peptide binding and T-cell receptor recognition. 
  • Ctr1 drives intestinal copper absorption and is essential for growth, iron metabolism, and neonatal cardiac function. 
  • Ctr1 is an apical copper transporter in mammalian intestinal epithelial cells in vivo that is controlled at the level of protein stability. 
  • Ctr2 Regulates Mast Cell Maturation by Affecting the Storage and Expression of Tryptase and Proteoglycans. 
  • Ctr2 regulates biogenesis of a cleaved form of mammalian Ctr1 metal transporter lacking the copper- and cisplatin-binding ecto-domain. 
  • Culture of endodermal stem/progenitor cells of the mouse tongue. 
  • Curative Treatment of Severe Gram-Negative Bacterial Infections by a New Class of Antibiotics Targeting LpxC. 
  • Current knowledge of the platelet glycoprotein IIb/IIIa receptor antagonists for the treatment of coronary artery disease. 
  • Cutaneous wound healing is impaired in hemophilia B. 
  • Cutaneous wound healing through paradoxical MAPK activation by BRAF inhibitors. 
  • Cutting Edge: Localization of linker for activation of T cells to lipid rafts is not essential in T cell activation and development. 
  • Cutting Edge: c-Maf Is Required for Regulatory T Cells To Adopt RORγt+ and Follicular Phenotypes. 
  • Cutting edge: ABIN-1 protects against psoriasis by restricting MyD88 signals in dendritic cells. 
  • Cutting edge: C3d functions as a molecular adjuvant in the absence of CD21/35 expression. 
  • Cutting edge: CD91-independent cross-presentation of GRP94(gp96)-associated peptides. 
  • Cutting edge: RIPK1 Kinase inactive mice are viable and protected from TNF-induced necroptosis in vivo. 
  • Cutting edge: Rapamycin augments pathogen-specific but not graft-reactive CD8+ T cell responses. 
  • Cutting edge: Role of osteopontin and integrin αv in T cell-mediated anti-inflammatory responses in endotoxemia. 
  • Cutting edge: TGF-beta-induced expression of Foxp3 in T cells is mediated through inactivation of ERK. 
  • Cutting edge: TLR4 deficiency confers susceptibility to lethal oxidant lung injury. 
  • Cutting edge: critical role of intracellular osteopontin in antifungal innate immune responses. 
  • Cutting edge: distinct glycolytic and lipid oxidative metabolic programs are essential for effector and regulatory CD4+ T cell subsets. 
  • Cutting edge: epigenetic regulation of Foxp3 defines a stable population of CD4+ regulatory T cells in tumors from mice and humans. 
  • Cutting edge: hierarchy of chemokine receptor and TCR signals regulating T cell migration and proliferation. 
  • Cutting edge: in vivo identification of TCR redistribution and polarized IL-2 production by naive CD4 T cells. 
  • Cutting edge: membrane lymphotoxin regulates CD8(+) T cell-mediated intestinal allograft rejection. 
  • Cutting edge: trimolecular interaction of TCR with MHC class II and bacterial superantigen shows a similar affinity to MHC:peptide ligands. 
  • Cybrd1 (duodenal cytochrome b) is not necessary for dietary iron absorption in mice. 
  • Cyclic AMP-dependent protein kinase catalytic subunits have divergent roles in virulence factor production in two varieties of the fungal pathogen Cryptococcus neoformans. 
  • Cyclic AMP-dependent protein kinase controls virulence of the fungal pathogen Cryptococcus neoformans. 
  • Cyclic AMP-regulated exocytosis of Escherichia coli from infected bladder epithelial cells. 
  • Cyclic Alopecia and Abnormal Epidermal Cornification in Zdhhc13-Deficient Mice Reveal the Importance of Palmitoylation in Hair and Skin Differentiation. 
  • Cyclic Regulation of Sensory Perception by a Female Hormone Alters Behavior. 
  • Cyclin D1 inhibits peroxisome proliferator-activated receptor gamma-mediated adipogenesis through histone deacetylase recruitment. 
  • Cyclin D1 overexpression and response to bortezomib treatment in a breast cancer model. 
  • Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits growth of a broad spectrum of cancer cells derived from solid tumors. 
  • Cyclocreatine (1-carboxymethyl-2-iminoimidazolidine) inhibits the replication of human herpes viruses. 
  • Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning. 
  • Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes. 
  • Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor). 
  • Cyclophosphamide diminishes inflammation and prolongs transgene expression following delivery of adenoviral vectors to mouse liver and lung. 
  • Cyclophosphamide treatment used to manipulate the immune response for the production of monoclonal antibodies. 
  • Cyclosporin A inhibits inositol 1,4,5-trisphosphate binding to its receptors and release of calcium from intracellular stores in peritoneal macrophages. 
  • Cyclosporin-A increases synthesis of 1,25-dihydroxyvitamin D3 in the rat and mouse. 
  • Cyclosporine inhibition of CH series murine B-cell lymphomas. 
  • Cyclosporine inhibition of a murine B cell lymphoma. 
  • Cyr61 mediates hepatocyte growth factor-dependent tumor cell growth, migration, and Akt activation. 
  • Cysteine 70 of ankyrin-G is S-palmitoylated and is required for function of ankyrin-G in membrane domain assembly. 
  • Cysteine-tailed class I-binding peptides bind to CpG adjuvant and enhance primary CTL responses. 
  • Cystic fibrosis transmembrane conductance regulator activation is reduced in the small intestine of Na+/H+ exchanger 3 regulatory factor 1 (NHERF-1)- but Not NHERF-2-deficient mice. 
  • Cystic fibrosis transmembrane regulator regulates uptake of sphingoid base phosphates and lysophosphatidic acid: modulation of cellular activity of sphingosine 1-phosphate. 
  • Cystine Deprivation Triggers Programmed Necrosis in VHL-Deficient Renal Cell Carcinomas. 
  • Cytochrome P1-450 structural gene in mouse, rat, and rabbit: differences in DNA methylation and developmental expression of mRNA. 
  • Cytochrome c deficiency causes embryonic lethality and attenuates stress-induced apoptosis. 
  • Cytochrome c peroxidase contributes to the antioxidant defense of Cryptococcus neoformans. 
  • Cytocidal amino acid starvation of Saccharomyces cerevisiae and Candida albicans acetolactate synthase (ilv2{Delta}) mutants is influenced by the carbon source and rapamycin. 
  • Cytogenetic changes induced by 1-(N1-methylhydrazinomethyl)-N-isopropyl benzamide in Ehrlich ascites tumor cells. 
  • Cytokine activation of nuclear factor kappa B in vascular smooth muscle cells requires signaling endosomes containing Nox1 and ClC-3. 
  • Cytokine deposition alters leukocyte morphology and initial recruitment of monocytes and γδT cells after corneal injury. 
  • Cytokine expression by invariant natural killer T cells is tightly regulated throughout development and settings of type-2 inflammation. 
  • Cytokine expression in vivo during murine herpetic stromal keratitis. Effect of protective antibody therapy. 
  • Cytokine requirements for induction of systemic and mucosal CTL after nasal immunization. 
  • Cytokine signals through STAT3 promote expression of granulocyte secondary granule proteins in 32D cells. 
  • Cytokine stimulation of aerobic glycolysis in hematopoietic cells exceeds proliferative demand. 
  • Cytokine stimulation promotes glucose uptake via phosphatidylinositol-3 kinase/Akt regulation of Glut1 activity and trafficking. 
  • Cytokine transcriptional events during helper T cell subset differentiation. 
  • Cytokine-dependent and cytokine-independent roles for Mcl-1: genetic evidence for multiple mechanisms by which Mcl-1 promotes survival in primary T lymphocytes. 
  • Cytokine-secreting follicular T cells shape the antibody repertoire. 
  • Cytokines as adjuvants for the induction of anti-human immunodeficiency virus peptide immunoglobulin G (IgG) and IgA antibodies in serum and mucosal secretions after nasal immunization. 
  • Cytokines in murine lyme carditis: Th1 cytokine expression follows expression of proinflammatory cytokines in a susceptible mouse strain. 
  • Cytoprotection by somatostatin of normal and malignant clonogenic cells against the in vitro cytotoxicity of bischloroethylnitrosourea (BCNU). 
  • Cytoprotection of PEG-modified adult porcine pancreatic islets for improved xenotransplantation. 
  • Cytosine methylation and suppression of O6-methylguanine-DNA methyltransferase expression in human rhabdomyosarcoma cell lines and xenografts. 
  • Cytosolic TMEM88 promotes invasion and metastasis in lung cancer cells by binding DVLS. 
  • Cytosolic phospholipase A(2) activity associated with nuclei is not inhibited by arachidonyl trifluoromethyl ketone in macrophages stimulated with receptor-recognized forms of alpha(2)-macroglobulin. 
  • Cytosolic phospholipase A2 alpha-deficient mice are resistant to experimental autoimmune encephalomyelitis. 
  • Cytotoxic T lymphocyte antigen 4 (CTLA4) blockade accelerates the acute rejection of cardiac allografts in CD28-deficient mice: CTLA4 can function independently of CD28. 
  • Cytotoxic effects of Mn(III) N-alkylpyridylporphyrins in the presence of cellular reductant, ascorbate. 
  • Cytotoxic-T-lymphocyte-mediated elimination of target cells transduced with engineered adeno-associated virus type 2 vector in vivo. 
  • Cytotoxicity of alpha-particle-emitting astatine-211-labelled antibody in tumour spheroids: no effect of hyperthermia. 
  • D-Amino acid peptide residualizing agents bearing N-hydroxysuccinimido- and maleimido-functional groups and their application for trastuzumab radioiodination. 
  • D1 dopamine receptor coupling to PLCβ regulates forward locomotion in mice. 
  • D6.1, a murine antimelanoma monoclonal antibody from congenitally athymic nude mice immunized with purified melanoma tumor-associated antigen. 
  • DCDC2 mutations cause a renal-hepatic ciliopathy by disrupting Wnt signaling. 
  • DDD mice, a novel acute mouse model of Parkinson's disease. 
  • DICER1 deficit induces Alu RNA toxicity in age-related macular degeneration. 
  • DISC1-dependent switch from progenitor proliferation to migration in the developing cortex. 
  • DMT1 expression is increased in the lungs of hypotransferrinemic mice. 
  • DNA Sequence Constraints Define Functionally Active Steroid Nuclear Receptor Binding Sites in Chromatin. 
  • DNA delivery from hyaluronic acid-collagen hydrogels via a substrate-mediated approach. 
  • DNA delivery from matrix metalloproteinase degradable poly(ethylene glycol) hydrogels to mouse cloned mesenchymal stem cells. 
  • DNA fragments from F9 PyEC mutants increase expression of heterologous genes in transfected F9 cells. 
  • DNA regulatory sequences of the rat tyrosine hydroxylase gene direct correct catecholaminergic cell-type specificity of a human growth hormone reporter in the CNS of transgenic mice causing a dwarf phenotype. 
  • DNA repair protein O6-alkylguanine-DNA alkyltransferase is phosphorylated by two distinct and novel protein kinases in human brain tumour cells. 
  • DNA vaccination by intradermal electroporation induces long-lasting immune responses in rhesus macaques. 
  • DNA vaccine molecular adjuvants SP-D-BAFF and SP-D-APRIL enhance anti-gp120 immune response and increase HIV-1 neutralizing antibody titers. 
  • DNA-PK facilitates piggyBac transposition by promoting paired-end complex formation. 
  • DNA-polycation nanospheres as non-viral gene delivery vehicles. 
  • DNA-remethylation around a STAT5-binding enhancer in the alphaS1-casein promoter is associated with abrupt shutdown of alphaS1-casein synthesis during acute mastitis. 
  • DNA/RNA helicase gene mutations in a form of juvenile amyotrophic lateral sclerosis (ALS4). 
  • DOK2 inhibits EGFR-mutated lung adenocarcinoma. 
  • DRAGON: a member of the repulsive guidance molecule-related family of neuronal- and muscle-expressed membrane proteins is regulated by DRG11 and has neuronal adhesive properties. 
  • DREADDing proglucagon neurons: a fresh look at metabolic regulation by the brain. 
  • DVT: a new era in anticoagulant therapy. 
  • Daily oral consumption of hydrolyzed type 1 collagen is chondroprotective and anti-inflammatory in murine posttraumatic osteoarthritis. 
  • Dancing with different partners: protein kinase a phosphorylation of seven membrane-spanning receptors regulates their G protein-coupling specificity. 
  • Dasatinib crosses the blood-brain barrier and is an efficient therapy for central nervous system Philadelphia chromosome-positive leukemia. 
  • Data analysis: evaluation of nanoscale contrast agent enhanced CT scan to differentiate between benign and malignant lung cancer in mouse model. 
  • Data and animal management software for large-scale phenotype screening. 
  • Daytime spikes in dopaminergic activity drive rapid mood-cycling in mice. 
  • Death-associated protein kinase 1 promotes growth of p53-mutant cancers. 
  • Deciphering the mechanisms of tumorigenesis in human pancreatic ductal epithelial cells. 
  • Deciphering the tête-à-tête between the microbiota and the immune system. 
  • Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging. 
  • Deconstructing B cell tolerance to basement membranes. 
  • Deconstructing behavioral neuropharmacology with cellular specificity. 
  • Deconstructing the genesis of animal form. 
  • Decreased (45)Ca(2)(+) uptake in P/Q-type calcium channels in homozygous lethargic (Cacnb4lh) mice is associated with increased beta3 and decreased beta4 calcium channel subunit mRNA expression. 
  • Decreased IGF-I gene expression during the apoptosis of Purkinje cells in pcd mice. 
  • Decreased PPAR gamma expression compromises perigonadal-specific fat deposition and insulin sensitivity. 
  • Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain. 
  • Decreased cochlear DNA receptor staining in MRL.MpJ-Fas(lpr) autoimmune mice with hearing loss. 
  • Decreased ethanol preference and consumption in dopamine transporter female knock-out mice. 
  • Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid. 
  • Decreased fibronectin expression in Met/HGF-mediated tumorigenesis. 
  • Decreased frequency and highly aberrant spectrum of ultraviolet-induced mutations in the hprt gene of mouse fibroblasts expressing antisense RNA to DNA polymerase zeta. 
  • Decreased frequency of somatic hypermutation and impaired affinity maturation but intact germinal center formation in mice expressing antisense RNA to DNA polymerase zeta. 
  • Decreased physical function and increased pain sensitivity in mice deficient for type IX collagen. 
  • Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice. 
  • Decreased tumorigenesis in mice with a Kras point mutation at C118. 
  • Deep-tissue anatomical imaging of mice using carbon nanotube fluorophores in the second near-infrared window. 
  • Deep-tissue photoacoustic tomography of a genetically encoded near-infrared fluorescent probe. 
  • Defective IL7R expression in T(-)B(+)NK(+) severe combined immunodeficiency. 
  • Defective PTH regulation of sodium-dependent phosphate transport in NHERF-1-/- renal proximal tubule cells and wild-type cells adapted to low-phosphate media. 
  • Defective T cell development and function in the absence of Abelson kinases. 
  • Defective antitumor responses in CX3CR1-deficient mice. 
  • Defective beta-adrenergic receptor signaling precedes the development of dilated cardiomyopathy in transgenic mice with calsequestrin overexpression. 
  • Defective coupling of apical PTH receptors to phospholipase C prevents internalization of the Na+-phosphate cotransporter NaPi-IIa in Nherf1-deficient mice. 
  • Defective glucose-stimulated insulin release from perifused islets of C57BL/6J mice. 
  • Defective glycolysis and calcium signaling underlie impaired insulin secretion in a transgenic mouse. 
  • Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. 
  • Defective mesonephric cell migration is associated with abnormal testis cord development in C57BL/6J XY(Mus domesticus) mice. 
  • Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function. 
  • Defective parathyroid hormone regulation of NHE3 activity and phosphate adaptation in cultured NHERF-1-/- renal proximal tubule cells. 
  • Defective prolactin signaling impairs pancreatic β-cell development during the perinatal period. 
  • Defective signaling in a subpopulation of CD4(+) T cells in the absence of Ca(2+)/calmodulin-dependent protein kinase IV. 
  • Defective survival and activation of thymocytes in transgenic mice expressing a catalytically inactive form of Ca2+/calmodulin-dependent protein kinase IV. 
  • Defects in intracellular trafficking of fungal cell wall synthases lead to aberrant host immune recognition. 
  • Defects in mononuclear phagocytic system (MPS) function in autoimmune MRL-lpr/lpr mice. 
  • Defects in neural stem cell proliferation and olfaction in Chd7 deficient mice indicate a mechanism for hyposmia in human CHARGE syndrome. 
  • Defects of prostate development and reproductive system in the estrogen receptor-alpha null male mice. 
  • Deferoxamine regulates neuroinflammation and iron homeostasis in a mouse model of postoperative cognitive dysfunction. 
  • Deficiencies in pro-thyrotropin-releasing hormone processing and abnormalities in thermoregulation in Cpefat/fat mice. 
  • Deficiency in Bak and Bax perturbs thymic selection and lymphoid homeostasis. 
  • Deficiency of 5-lipoxygenase abolishes sex-related survival differences in MRL-lpr/lpr mice. 
  • Deficiency of 5-lipoxygenase accelerates renal allograft rejection in mice. 
  • Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition. 
  • Deficiency of asparagine synthetase causes congenital microcephaly and a progressive form of encephalopathy. 
  • Deficiency of double-strand DNA break repair does not impair Mycobacterium tuberculosis virulence in multiple animal models of infection. 
  • Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis. 
  • Deficiency of heme-regulated eIF2alpha kinase decreases hepcidin expression and splenic iron in HFE-/- mice. 
  • Deficiency of the lipid synthesis enzyme, DGAT1, extends longevity in mice. 
  • Deficiency of α-actinin-3 is associated with increased susceptibility to contraction-induced damage and skeletal muscle remodeling. 
  • Deficient Smad7 expression: a putative molecular defect in scleroderma. 
  • Deficient serotonin neurotransmission and depression-like serotonin biomarker alterations in tryptophan hydroxylase 2 (Tph2) loss-of-function mice. 
  • Deficits in passive avoidance and fear behavior following bilateral and unilateral amygdala lesions in mice. 
  • Deficits in reproduction and pro-gonadotropin-releasing hormone processing in male Cpefat mice. 
  • Defining Potential Vaccine Targets of Haemophilus ducreyi Trimeric Autotransporter Adhesin DsrA. 
  • Defining a link with autosomal-dominant polycystic kidney disease in mice with congenitally low expression of Pkd1. 
  • Defining a second epitope for heparin-induced thrombocytopenia/thrombosis antibodies using KKO, a murine HIT-like monoclonal antibody. 
  • Defining fibronectin's cell adhesion synergy site by site-directed mutagenesis. 
  • Defining the cooperative genetic changes that temporally drive alveolar rhabdomyosarcoma. 
  • Definition of a lipopolysaccharide-responsive element in the 5'-flanking regions of MuRantes and crg-2. 
  • Definition of a novel cellular constituent of the bone marrow that regulates the response of immature B cells to B cell antigen receptor engagement. 
  • Delayed apoptotic cell clearance and lupus-like autoimmunity in mice lacking the c-mer membrane tyrosine kinase. 
  • Delayed fracture healing and increased callus adiposity in a C57BL/6J murine model of obesity-associated type 2 diabetes mellitus. 
  • Delayed wound healing in the absence of intercellular adhesion molecule-1 or L-selectin expression. 
  • Deletion and site-directed mutagenesis of the ATP-binding motif (P-loop) in the bifunctional murine ATP-sulfurylase/adenosine 5'-phosphosulfate kinase enzyme. 
  • Deletion of CD4 and CD8 coreceptors permits generation of alphabetaT cells that recognize antigens independently of the MHC. 
  • Deletion of CaMKK2 from the liver lowers blood glucose and improves whole-body glucose tolerance in the mouse. 
  • Deletion of GSK3β in D2R-expressing neurons reveals distinct roles for β-arrestin signaling in antipsychotic and lithium action. 
  • Deletion of GαZ protein protects against diet-induced glucose intolerance via expansion of β-cell mass. 
  • Deletion of PIK3C3/Vps34 in sensory neurons causes rapid neurodegeneration by disrupting the endosomal but not the autophagic pathway. 
  • Deletion of Trpm7 disrupts embryonic development and thymopoiesis without altering Mg2+ homeostasis. 
  • Deletion of Y chromosome sequences located outside the testis determining region can cause XY female sex reversal. 
  • Deletion of a conserved cis-element in the Ifng locus highlights the role of acute histone acetylation in modulating inducible gene transcription. 
  • Deletion of a splicing enhancer disrupts PLP1/DM20 ratio and myelin stability. 
  • Deletion of angiotensin II type 2 receptor accelerates adipogenesis in murine mesenchymal stem cells via Wnt10b/beta-catenin signaling. 
  • Deletion of p16 and p15 genes in brain tumors. 
  • Deletion of p47phox attenuates angiotensin II-induced abdominal aortic aneurysm formation in apolipoprotein E-deficient mice. 
  • Deletion of presenilin 1 hydrophilic loop sequence leads to impaired gamma-secretase activity and exacerbated amyloid pathology. 
  • Deletion of the carboxyl terminus of Tie2 enhances kinase activity, signaling, and function. Evidence for an autoinhibitory mechanism. 
  • Deletion of the glutamate carboxypeptidase II gene in mice reveals a second enzyme activity that hydrolyzes N-acetylaspartylglutamate. 
  • Deletion of the protein kinase A/protein kinase G target SMTNL1 promotes an exercise-adapted phenotype in vascular smooth muscle. 
  • Deletion of the transient receptor potential cation channel TRPV4 impairs murine bladder voiding. 
  • Delineating muscarinic receptor functions. 
  • Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer. 
  • Delineation of the regions of interleukin-2 (IL-2) receptor beta chain important for association of Jak1 and Jak3. Jak1-independent functional recruitment of Jak3 to Il-2Rbeta. 
  • Delivery of CCL21 to metastatic disease improves the efficacy of adoptive T-cell therapy. 
  • Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers. 
  • Delivery of viral vectors to tumor cells: extracellular transport, systemic distribution, and strategies for improvement. 
  • Delivery rate affects uptake of a fluorescent glucose analog in murine metastatic breast cancer. 
  • Delivery-corrected imaging of fluorescently-labeled glucose reveals distinct metabolic phenotypes in murine breast cancer. 
  • Delta-like 1 homolog (dlk1): a marker for rhabdomyosarcomas implicated in skeletal muscle regeneration. 
  • Delta-like 1-Lysine613 regulates notch signaling. 
  • Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. 
  • Demineralized murine skeletal histology. 
  • Demonstration that mutation of the type II transforming growth factor beta receptor inactivates its tumor suppressor activity in replication error-positive colon carcinoma cells. 
  • Dendritic cell immunoreceptor regulates Chikungunya virus pathogenesis in mice. 
  • Dendritic cell responses to early murine cytomegalovirus infection: subset functional specialization and differential regulation by interferon alpha/beta. 
  • Dendritic cell transmigration through brain microvessel endothelium is regulated by MIP-1alpha chemokine and matrix metalloproteinases. 
  • Dendritic cell-based immunotherapy in prevention and treatment of renal cell carcinoma: efficacy, safety, and activity of Ad-GM·CAIX in immunocompetent mouse models. 
  • Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. 
  • Dendritic cell/macrophage precursors capture exogenous antigen for MHC class I presentation by dendritic cells. 
  • Dendritic cells engineered to secrete anti-GITR antibodies are effective adjuvants to dendritic cell-based immunotherapy. 
  • Dendritic cells pulsed with RNA are potent antigen-presenting cells in vitro and in vivo. 
  • Dendritic cells pulsed with a tumor-specific peptide induce long-lasting immunity and are effective against murine intracerebral melanoma. 
  • Dendritic cells with TGF-beta1 differentiate naive CD4+CD25- T cells into islet-protective Foxp3+ regulatory T cells. 
  • Dendritic epidermal T cells regulate skin antimicrobial barrier function. 
  • Dependence of corneal stem/progenitor cells on ocular surface innervation. 
  • Dependence of germinal center B cells on expression of CD21/CD35 for survival. 
  • Dependence of serotonergic and other nonadrenergic enteric neurons on norepinephrine transporter expression. 
  • Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function. 
  • Depletion of passenger leukocytes from corneal grafts: an effective means of promoting transplant survival? 
  • Depolarization-stimulated cholecystokinin secretion is mediated by L-type calcium channels in STC-1 cells. 
  • Depressed expression of adipocyte beta-adrenergic receptors is a common feature of congenital and diet-induced obesity in rodents. 
  • Depression of macrophage function by a factor produced by neoplasms: a merchanism for abrogation of immune surveillance. 
  • Depression of murine macrophage accumulation by low-molecular-weight derived from spontaneous mammary carcinomas. 
  • Derangements of hippocampal calcium/calmodulin-dependent protein kinase II in a mouse model for Angelman mental retardation syndrome. 
  • Derepression of BDNF transcription involves calcium-dependent phosphorylation of MeCP2. 
  • Derivation of a biologically contained replication system for human immunodeficiency virus type 1. 
  • Derivation of chondrogenically-committed cells from human embryonic cells for cartilage tissue regeneration. 
  • Derivation of non-infectious envelope proteins from virions isolated from plasma negative for HIV antibodies. 
  • Derivation of pluripotential embryonic stem cells from murine primordial germ cells in culture. 
  • Description of monoclonal antibody defining an HLA allotypic determinant that includes specificities within the B5 cross-reacting group. 
  • Desensitization of angiotensin receptor function. 
  • Desensitization of the mouse thromboxane A2 receptor (TP) by G protein-coupled receptor kinases (Grks). 
  • Desert Hedgehog/Patched 1 signaling specifies fetal Leydig cell fate in testis organogenesis. 
  • Design and analysis of large-scale biological rhythm studies: a comparison of algorithms for detecting periodic signals in biological data. 
  • Design and characterization of a peptide mimotope of the HIV-1 gp120 bridging sheet. 
  • Design and characterization of microporous hyaluronic acid hydrogels for in vitro gene transfer to mMSCs. 
  • Design and validation of a dynamic cell-culture system for bone biology research and exogenous tissue-engineering applications. 
  • Design of a novel small peptide targeted against a tumor-specific receptor. 
  • Design of a superconducting volume coil for magnetic resonance microscopy of the mouse brain. 
  • Designer monotransregulators provide a basis for a transcriptional therapy for de novo endocrine-resistant breast cancer. 
  • Desmoplakin controls microvilli length but not cell adhesion or keratin organization in the intestinal epithelium. 
  • Desmoplakin: an unexpected regulator of microtubule organization in the epidermis. 
  • Destruction of Myc by ubiquitin-mediated proteolysis: cancer-associated and transforming mutations stabilize Myc. 
  • Detailed analysis of gene expression during development of T cell lineages in the thymus. 
  • Detection of Ebola virus envelope using monoclonal and polyclonal antibodies in ELISA, surface plasmon resonance and a quartz crystal microbalance immunosensor. 
  • Detection of Escherichia coli enterotoxins in stools. 
  • Detection of a transformation-specific glycopeptide in SSV-infected cells. 
  • Detection of chromatin-associated single-stranded DNA in regions targeted for somatic hypermutation. 
  • Detection of early changes in renal function using 99mTc-MAG3 imaging in a murine model of ischemia-reperfusion injury. 
  • Detection of iron-labeled single cells by MR imaging based on intermolecular double quantum coherences at 14 T. 
  • Detection of metastatic tumors in nude mice: brief communication. 
  • Detection of mouse cytomegalovirus nucleic acid in latently infected mice by in vitro enzymatic amplification. 
  • Detection of murine cytomegalovirus immediate early 1 transcripts in the spleens of latently infected mice. 
  • Detection of near-atmospheric concentrations of CO2 by an olfactory subsystem in the mouse. 
  • Detection of oncornavirus antigenic activity in human urothelial tissues. 
  • Detection of pathogen-specific antibodies by loop-mediated isothermal amplification. 
  • Detection of the major glycoproteins of Friend leukemia virus (gp71) and the murine mammary tumor virus (gp52) on the surface of mouse cells. 
  • Detergents linked to polysaccharides: preparation and effects on membranes and cells. 
  • Determinants of PF4/heparin immunogenicity. 
  • Determinants of the source of cytomegalovirus in murine renal allograft recipients. 
  • Determination of an angiotensin II-regulated proteome in primary human kidney cells by stable isotope labeling of amino acids in cell culture (SILAC). 
  • Determination of electric parameters of cell membranes by a dielectrophoresis method. 
  • Determination of estrogen receptor messenger ribonucleic acid (mRNA) and cytochrome P450 aromatase mRNA levels in adipocytes and adipose stromal cells by competitive polymerase chain reaction amplification. 
  • Determination of the functional status of alloreactive T cells by interferon-gamma kinetics. 
  • Determining the absolute requirement of G protein-coupled receptor kinase 5 for pathological cardiac hypertrophy: short communication. 
  • Determining γδ versus αß T cell development. 
  • Deterministic transfection drives efficient nonviral reprogramming and uncovers reprogramming barriers. 
  • Developing an HIV vaccine. 
  • Developing nodes of Ranvier are defined by ankyrin-G clustering and are independent of paranodal axoglial adhesion. 
  • Development and Preliminary Evaluation of a Murine Model of Chronic Radiation-Induced Proctitis. 
  • Development and application of basic research techniques in bladder cancer research. 
  • Development and biological evaluation of ⁹⁹mTc-sulfonamide derivatives for in vivo visualization of CA IX as surrogate tumor hypoxia markers. 
  • Development and characterization of a fusion protein between thermally responsive elastin-like polypeptide and interleukin-1 receptor antagonist: sustained release of a local antiinflammatory therapeutic. 
  • Development and characterization of a monoclonal antibody to human embryonal carcinoma. 
  • Development and distribution of a human B cell subpopulation identified by the HB-4 monoclonal antibody. 
  • Development and plasticity of outer retinal circuitry following genetic removal of horizontal cells. 
  • Development and preclinical evaluation of an alphavirus replicon particle vaccine for cytomegalovirus. 
  • Development and preclinical evaluation of an alphavirus replicon vaccine for influenza. 
  • Development and use of SIV-based Integrase defective lentiviral vector for immunization. 
  • Development and validation of a cell-based fluorescent method for measuring antibody affinity. 
  • Development of DX-9065a, a novel direct factor Xa antagonist, in cardiovascular disease. 
  • Development of Patient-specific AAV Vectors After Neutralizing Antibody Selection for Enhanced Muscle Gene Transfer. 
  • Development of Saccharomyces cerevisiae as a model pathogen. A system for the genetic identification of gene products required for survival in the mammalian host environment. 
  • Development of a 4-D digital mouse phantom for molecular imaging research. 
  • Development of a colon cancer GEMM-derived orthotopic transplant model for drug discovery and validation. 
  • Development of a fluorescence detection system using optical parametric oscillator (OPO) laser excitation for in vivo diagnosis. 
  • Development of a membrane-anchored chemerin receptor agonist as a novel modulator of allergic airway inflammation and neuropathic pain. 
  • Development of a model of melphalan-induced gastrointestinal toxicity in mice. 
  • Development of a monoclonal antibody specific for serotype 3 rotavirus strains. 
  • Development of a novel adjuvanted nasal vaccine: C48/80 associated with chitosan nanoparticles as a path to enhance mucosal immunity. 
  • Development of a novel surrogate virus for human T-cell leukemia virus type 1: inhibition of infection by osteoprotegerin. 
  • Development of a recombinant yellow fever vector expressing a HIV clade C founder envelope gp120. 
  • Development of a simplified spinal cord ischemia model in mice. 
  • Development of an ER action indicator mouse for the study of estrogens, selective ER modulators (SERMs), and Xenobiotics. 
  • Development of an advanced hyperspectral imaging (HSI) system with applications for cancer detection. 
  • Development of an aerosol model of Cryptococcus reveals humidity as an important factor affecting the viability of Cryptococcus during aerosolization. 
  • Development of bioactive photocrosslinkable fibrous hydrogels. 
  • Development of glomerular pattern visualized in the olfactory bulbs of living mice. 
  • Development of intracellular bacterial communities of uropathogenic Escherichia coli depends on type 1 pili. 
  • Development of mammary hyperplasia and neoplasia in MMTV-TGF alpha transgenic mice. 
  • Development of pemphigus vulgaris-like lesions in severe combined immunodeficiency disease mice reconstituted with lymphocytes from patients. 
  • Development, maintenance, and function of the adrenal gland in early postnatal proopiomelanocortin-null mutant mice. 
  • Development, validation and characterization of a novel mouse model of Adynamic Bone Disease (ABD). 
  • Development-dependent disappearance of caspase-3 in skeletal muscle is post-transcriptionally regulated. 
  • Developmental History Provides a Roadmap for the Emergence of Tumor Plasticity. 
  • Developmental activation of the TCR alpha enhancer requires functional collaboration among proteins bound inside and outside the core enhancer. 
  • Developmental analysis of ocular morphogenesis in alpha A-crystallin/diphtheria toxin transgenic mice undergoing ablation of the lens. 
  • Developmental and osteoarthritic changes in Col6a1-knockout mice: biomechanics of type VI collagen in the cartilage pericellular matrix. 
  • Developmental and spatial patterns of expression of the mouse homeobox gene, Hox 2.1. 
  • Developmental and transformation-sensitive expression of the Sparc gene on mouse chromosome 11. 
  • Developmental biology. Another hit for gene targeting. 
  • Developmental biology. Branching takes nerve. 
  • Developmental biology. The making of the ear. 
  • Developmental biology: decisions, decisions! 
  • Developmental defects in mouse embryos lacking N-cadherin. 
  • Developmental exposure to noninherited maternal antigens induces CD4+ T regulatory cells: relevance to mechanism of heart allograft tolerance. 
  • Developmental expression of 2ar (osteopontin) and SPARC (osteonectin) RNA as revealed by in situ hybridization. 
  • Developmental expression of extracellular glutathione peroxidase suggests antioxidant roles in deciduum, visceral yolk sac, and skin. 
  • Developmental expression of glycogenolytic enzymes in rabbit tissues: possible relationship to fetal lung maturation. 
  • Developmental expression of renal angiotensin II receptor genes in the mouse. 
  • Developmental expression of tissue inhibitor of metalloproteinase (TIMP) RNA. 
  • Developmental regulation of VDJ recombination by the core fragment of the T cell receptor alpha enhancer. 
  • Developmental regulation of alpha beta T cell antigen receptor expression results from differential stability of nascent TCR alpha proteins within the endoplasmic reticulum of immature and mature T cells. 
  • Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs. 
  • Developmental regulation of cytochrome oxidase subunit VIa isoforms in cardiac and skeletal muscle. 
  • Developmental regulation of lymphocyte-specific protein 1 (LSP1) expression in thymus during human T-cell maturation. 
  • Developmental regulation of mouse SPARC (osteonectin) gene expression. 
  • Developmental renin expression in mice with a defective renin-angiotensin system. 
  • Developmental stage-dependent effects of cardiac fibroblasts on function of stem cell-derived engineered cardiac tissues. 
  • Developmental stage-specific expression of the alpha and beta subunits of the HIF-1 protein in the mouse and human fetus. 
  • Developmental stratification of the mammary epithelium occurs through symmetry-breaking vertical divisions of apically positioned luminal cells. 
  • Developmentally regulated changes in femoral nerve regeneration in the mouse and rat. 
  • Dexamethasone potentiates in vitro blood-brain barrier recovery after primary blast injury by glucocorticoid receptor-mediated upregulation of ZO-1 tight junction protein. 
  • Dexmedetomidine provides renoprotection against ischemia-reperfusion injury in mice. 
  • Diabetes insipidus in uricase-deficient mice: a model for evaluating therapy with poly(ethylene glycol)-modified uricase. 
  • Diabetic kidney disease in FVB/NJ Akita mice: temporal pattern of kidney injury and urinary nephrin excretion. 
  • Diabetic liver injury from streptozotocin is regulated through the caspase-8 homolog cFLIP involving activation of JNK2 and intrahepatic immunocompetent cells. 
  • Diabetic nephropathy: of mice and men. 
  • Diacylglycerol acyltranferase 1 anti-sense oligonucleotides reduce hepatic fibrosis in mice with nonalcoholic steatohepatitis. 
  • Diacylglycerol kinase zeta positively controls the development of iNKT-17 cells. 
  • Diacylglycerol kinase zeta regulates actin cytoskeleton reorganization through dissociation of Rac1 from RhoGDI. 
  • Diacylglycerol kinase zeta regulates microbial recognition and host resistance to Toxoplasma gondii. 
  • Diacylglycerol kinase ζ deficiency in a non-CD4(+) T-cell compartment leads to increased peanut hypersensitivity. 
  • Diacylglycerol kinase ζ limits B cell antigen receptor-dependent activation of ERK signaling to inhibit early antibody responses. 
  • Diagnosis of partial body radiation exposure in mice using peripheral blood gene expression profiles. 
  • Diarrhoea associated with heat-stable enterotoxin-producing strains of Escherichia coli. 
  • Diarylureas are small-molecule inhibitors of insulin-like growth factor I receptor signaling and breast cancer cell growth. 
  • Diazoxide restores beta3-adrenergic receptor function in diet-induced obesity and diabetes. 
  • Dicationic furans inhibit development of Cryptosporidium parvum in HSD/ICR suckling Swiss mice. 
  • Dicer1 functions as a haploinsufficient tumor suppressor. 
  • Dicistronic polioviruses as expression vectors for foreign genes. 
  • Dickkopf-1 promotes hematopoietic regeneration via direct and niche-mediated mechanisms. 
  • Dielectrophoresis and electrorotation of neurospora slime and murine myeloma cells. 
  • Diet-induced changes in uncoupling proteins in obesity-prone and obesity-resistant strains of mice. 
  • Diet-induced obese mice retain endogenous leptin action. 
  • Diet-induced obesity alters the differentiation potential of stem cells isolated from bone marrow, adipose tissue and infrapatellar fat pad: the effects of free fatty acids. 
  • Diet-induced obesity differentially regulates behavioral, biomechanical, and molecular risk factors for osteoarthritis in mice. 
  • Diet-induced obesity significantly increases the severity of posttraumatic arthritis in mice. 
  • Diet-induced type II diabetes in C57BL/6J mice. 
  • Dietary Restriction and AMPK Increase Lifespan via Mitochondrial Network and Peroxisome Remodeling. 
  • Dietary factors alter hepatic innate immune system in mice with nonalcoholic fatty liver disease. 
  • Dietary fatty acid content regulates wound repair and the pathogenesis of osteoarthritis following joint injury. 
  • Dietary intervention strategies to modulate prostate cancer risk and prognosis. 
  • Dietary isothiocyanate-induced apoptosis via thiol modification of DNA topoisomerase IIα. 
  • Dietary manipulation of serotonergic and dopaminergic function in C57BL/6J mice with amino acid depletion mixtures. 
  • Dietary nitrate attenuates renal ischemia-reperfusion injuries by modulation of immune responses and reduction of oxidative stress. 
  • Dietary supplementation with fresh pineapple juice decreases inflammation and colonic neoplasia in IL-10-deficient mice with colitis. 
  • Differences between particulate and peptide stimuli on activation of oxidant production in alveolar macrophages. 
  • Differences in V kappa gene utilization and VH CDR3 sequence among anti-DNA from C3H-lpr mice and lupus mice with nephritis. 
  • Differences in intraepithelial lymphocyte T cell subsets isolated from murine small versus large intestine. 
  • Differences in receptor binding and stability to enzymatic digestion between CCK-8 and CCK-58. 
  • Differences in the Antinociceptive Effects and Binding Properties of Propranolol and Bupranolol Enantiomers. 
  • Differences in the absorption, metabolism and biliary excretion of a diastereomeric pair of alphavbeta3-antagonists in rat: limited role of P-glycoprotein. 
  • Differences in the central anorectic effects of glucagon-like peptide-1 and exendin-4 in rats. 
  • Different immune cells mediate mechanical pain hypersensitivity in male and female mice. 
  • Different mechanisms preclude mutant CLDN14 proteins from forming tight junctions in vitro. 
  • Different presynaptic roles of synapsins at excitatory and inhibitory synapses. 
  • Different roles for matrix metalloproteinase-2 and matrix metalloproteinase-9 in the pathogenesis of cardiac allograft rejection. 
  • Different secretory pathways of renin from mouse cells transfected with the human renin gene. 
  • Differential Immune Microenvironments and Response to Immune Checkpoint Blockade among Molecular Subtypes of Murine Medulloblastoma. 
  • Differential Induction of Immunogenic Cell Death and Interferon Expression in Cancer Cells by Structured ssRNAs. 
  • Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7 : Differential activities of Nav1.7-targeting monoclonal antibodies. 
  • Differential Role of B Cells and IL-17 Versus IFN-γ During Early and Late Rejection of Pig Islet Xenografts in Mice. 
  • Differential Sensitivity to Ethanol-Induced Circadian Rhythm Disruption in Adolescent and Adult Mice. 
  • Differential adherence of hydrophobic and hydrophilic Candida albicans yeast cells to mouse tissues. 
  • Differential anti-inflammatory effects of LPS in susceptible and resistant mouse strains. 
  • Differential coordination demands in Fe versus Mn water-soluble cationic metalloporphyrins translate into remarkably different aqueous redox chemistry and biology. 
  • Differential corticostriatal plasticity during fast and slow motor skill learning in mice. 
  • Differential developmental toxicity of naphthoic acid isomers in medaka (Oryzias latipes) embryos. 
  • Differential display of proteins involved in the neural differentiation of mouse embryonic carcinoma P19 cells by comparative proteomic analysis. 
  • Differential effects mediated by GABAA receptors in thalamic nuclei in lh/lh model of absence seizures. 
  • Differential effects of doxycycline, a broad-spectrum matrix metalloproteinase inhibitor, on angiotensin II-induced atherosclerosis and abdominal aortic aneurysms. 
  • Differential effects of fat and sucrose on body composition in A/J and C57BL/6 mice. 
  • Differential effects of fat and sucrose on the development of obesity and diabetes in C57BL/6J and A/J mice. 
  • Differential effects of insulin-like growth factor (IGF)-binding protein-3 and its proteolytic fragments on ligand binding, cell surface association, and IGF-I receptor signaling. 
  • Differential effects of toll-like receptor stimulation on mRNA-driven myogenic conversion of human and mouse fibroblasts. 
  • Differential effects of unfolded protein response pathways on axon injury-induced death of retinal ganglion cells. 
  • Differential effects of vascular endothelial growth factor receptor-2 inhibitor ZD6474 on circulating endothelial progenitors and mature circulating endothelial cells: implications for use as a surrogate marker of antiangiogenic activity. 
  • Differential expression of VEGF isoforms in mouse during development and in the adult. 
  • Differential expression of a sialoglycoprotein with an approximate molecular weight of 900,000 on metastatic human colon carcinoma cells growing in culture and in tumor tissues. 
  • Differential expression of genes encoding TGFs beta 1, beta 2, and beta 3 during murine palate formation. 
  • Differential expression of intracellular and secreted osteopontin isoforms by murine macrophages in response to toll-like receptor agonists. 
  • Differential expression of multiple fork head related genes during gastrulation and axial pattern formation in the mouse embryo. 
  • Differential expression of p63 isoforms in female reproductive organs. 
  • Differential expression of procollagen genes between mid- and late-gestational fetal fibroblasts. 
  • Differential expression of the ARF GAP genes GIT1 and GIT2 in mouse tissues. 
  • Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes. 
  • Differential gene expression in mouse sclera during ocular development. 
  • Differential gene expression in the distal tip endoderm of the embryonic mouse lung. 
  • Differential glycemic effects of morphine in diabetic and normal mice. 
  • Differential loss of prolyl isomerase or chaperone activity of Ran-binding protein 2 (Ranbp2) unveils distinct physiological roles of its cyclophilin domain in proteostasis. 
  • Differential mRNA expression and protein localization of the SAP90/PSD-95-associated proteins (SAPAPs) in the nervous system of the mouse. 
  • Differential mechanisms of morphine antinociceptive tolerance revealed in (beta)arrestin-2 knock-out mice. 
  • Differential molecular mechanism of the estrogen action that regulates lactoferrin gene in human and mouse. 
  • Differential myocardial gene expression in the development and rescue of murine heart failure. 
  • Differential orientation of 10T1/2 mesenchymal cells on non-uniform stretch environments. 
  • Differential osteopontin expression in phenotypically distinct subclones of murine breast cancer cells mediates metastatic behavior. 
  • Differential phosphorylation of functional tyrosines in CD19 modulates B-lymphocyte activation. 
  • Differential psychostimulant-induced activation of neural circuits in dopamine transporter knockout and wild type mice. 
  • Differential pulmonary transcriptomic profiles in murine lungs infected with low and highly virulent influenza H3N2 viruses reveal dysregulation of TREM1 signaling, cytokines, and chemokines. 
  • Differential quantal release of histamine and 5-hydroxytryptamine from mast cells of vesicular monoamine transporter 2 knockout mice. 
  • Differential regulation of MeCP2 phosphorylation in the CNS by dopamine and serotonin. 
  • Differential regulation of calcineurin isoforms in transplant patients: a new look at an old problem. 
  • Differential regulation of primary and memory CD8 T cell immune responses by diacylglycerol kinases. 
  • Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice. 
  • Differential regulation of the PGC family of genes in a mouse model of Staphylococcus aureus sepsis. 
  • Differential regulation of the dopamine D1, D2 and D3 receptor gene expression and changes in the phenotype of the striatal neurons in mice lacking the dopamine transporter. 
  • Differential regulation of tyrosine hydroxylase in the basal ganglia of mice lacking the dopamine transporter. 
  • Differential requirement for the SAP-Fyn interaction during NK T cell development and function. 
  • Differential requirement of RasGRP1 for γδ T cell development and activation. 
  • Differential response of ventral midbrain and striatal progenitor cells to lesions of the nigrostriatal dopaminergic projection. 
  • Differential roles of Aβ processing in hypoxia-induced axonal damage. 
  • Differential seizure sensitivities to picrotoxinin in two inbred strains of mice (DBA/2J and BALB/c ByJ): parallel changes in GABA receptor-mediated chloride flux and receptor binding. 
  • Differential sensitivity of murine leukemia virus to APOBEC3-mediated inhibition is governed by virion exclusion. 
  • Differential uptake of DNA-poly(ethylenimine) polyplexes in cells cultured on collagen and fibronectin surfaces. 
  • Differentiation of a catecholaminergic CNS cell line modifies tyrosine hydroxylase transcriptional regulation. 
  • Differentiation of erythroleukemia cells in vitro: properties of chemical inducers. 
  • Differentiation of human T lymphocytes. I. Acquisition of a novel human cell surface protein (p80) during normal intrathymic T cell maturation. 
  • Differentiation of mammalian skeletal muscle cells cultured on microcarrier beads in a rotating cell culture system. 
  • Differentiation of mouse induced pluripotent stem cells (iPSCs) into nucleus pulposus-like cells in vitro. 
  • Differentiation- and stress-dependent nuclear cytoplasmic redistribution of myopodin, a novel actin-bundling protein. 
  • Diffusion tensor imaging analysis of the brain in the canine model of Krabbe disease. 
  • Diffusion tensor imaging using multiple coils for mouse brain connectomics. 
  • Difluoromethylornithine is a novel inhibitor of Helicobacter pylori growth, CagA translocation, and interleukin-8 induction. 
  • Digital atlasing and standardization in the mouse brain. 
  • Digoxin and its derivatives suppress TH17 cell differentiation by antagonizing RORγt activity. 
  • Dimerization and ubiquitin mediated recruitment of A20, a complex deubiquitinating enzyme. 
  • Dimethylsphingosine and FTY720 inhibit the SK1 form but activate the SK2 form of sphingosine kinase from rat heart. 
  • Dioxin induces transcription of fos and jun genes by Ah receptor-dependent and -independent pathways. 
  • Diphtheria toxin-epidermal growth factor fusion protein DAB389EGF for the treatment of bladder cancer. 
  • Dipyridamole-cisplatin potentiation: enhanced in vivo cytotoxicity in xenograft models of human testicular and bladder cancers. 
  • Direct Conversion of Human Pluripotent Stem Cells to Osteoblasts With a Small Molecule. 
  • Direct TLR2 signaling is critical for NK cell activation and function in response to vaccinia viral infection. 
  • Direct action of type I IFN on NK cells is required for their activation in response to vaccinia viral infection in vivo. 
  • Direct binding of activated c-Src to the beta 3-adrenergic receptor is required for MAP kinase activation. 
  • Direct correlation between DNA repair capacity and metastatic potential of K-1735 murine melanoma cells. 
  • Direct demonstration of elevated aldehyde dehydrogenase in human hematopoietic progenitor cells. 
  • Direct gene transfer of human CFTR into human bronchial epithelia of xenografts with E1-deleted adenoviruses. 
  • Direct in vivo evidence for tumor propagation by glioblastoma cancer stem cells. 
  • Direct in vivo measurement of targeted binding in a human tumor xenograft. 
  • Direct measurement of hypoxia in a xenograft multiple myeloma model by optical-resolution photoacoustic microscopy. 
  • Direct reprogramming of cardiac fibroblasts to cardiomyocytes using microRNAs. 
  • Direct role of Bardet-Biedl syndrome proteins in transcriptional regulation. 
  • Direct sequencing of the activation peptide and the catalytic domain of the factor IX gene in six species. 
  • Direct-contact co-culture between smooth muscle and endothelial cells inhibits TNF-alpha-mediated endothelial cell activation. 
  • Directed enzyme pro-drug gene therapy for pancreatic cancer in vivo. 
  • Directed in vitro myogenesis of human embryonic stem cells and their in vivo engraftment. 
  • Directed intermixing in multicomponent self-assembling biomaterials. 
  • Directing and Potentiating Stem Cell-Mediated Angiogenesis and Tissue Repair by Cell Surface E-Selectin Coating. 
  • Directionality of temperature activation in mouse TRPA1 ion channel can be inverted by single-point mutations in ankyrin repeat six. 
  • Disabled homolog 2 controls macrophage phenotypic polarization and adipose tissue inflammation. 
  • Disc1 regulates granule cell migration in the developing hippocampus. 
  • Discordant complement systems as a factor in hyperacute xenograft rejection. 
  • Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo. 
  • Discovery and characterization of small molecules that target the GTPase Ral. 
  • Discovery and optimization of imidazo[1,2-a]pyridine inhibitors of insulin-like growth factor-1 receptor (IGF-1R). 
  • Discovery of 5-[[4-[(2,3-dimethyl-2H-indazol-6-yl)methylamino]-2-pyrimidinyl]amino]-2-methyl-benzenesulfonamide (Pazopanib), a novel and potent vascular endothelial growth factor receptor inhibitor. 
  • Discovery of 6-Fluoro-5-(R)-(3-(S)-(8-fluoro-1-methyl-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)-2-methylphenyl)-2-(S)-(2-hydroxypropan-2-yl)-2,3,4,9-tetrahydro-1H-carbazole-8-carboxamide (BMS-986142): A Reversible Inhibitor of Bruton's Tyrosine Kinase (BTK) Conformationally Constrained by Two Locked Atropisomers. 
  • Discovery of Age-Related Protein Folding Stability Differences in the Mouse Brain Proteome. 
  • Discovery of LSZ102, a Potent, Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) for the Treatment of Estrogen Receptor Positive Breast Cancer. 
  • Discovery of [(3-bromo-7-cyano-2-naphthyl)(difluoro)methyl]phosphonic acid, a potent and orally active small molecule PTP1B inhibitor. 
  • Discovery of a novel Toxoplasma gondii conoid-associated protein important for parasite resistance to reactive nitrogen intermediates. 
  • Discovery of an inhibitor of insulin-like growth factor 1 receptor activation: implications for cellular potency and selectivity over insulin receptor. 
  • Discovery of biomarker candidates for coronary artery disease from an APOE-knock out mouse model using iTRAQ-based multiplex quantitative proteomics. 
  • Discovery of novel ligands for mouse olfactory receptor MOR42-3 using an in silico screening approach and in vitro validation. 
  • Discovery of novel targets of quinoline drugs in the human purine binding proteome. 
  • Discovery of protein- and DNA-imperceptible nanoparticle hard coating using gel-based reaction tuning. 
  • Discovery of thiophene inhibitors of polo-like kinase. 
  • Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy. 
  • Discrete amino acid sequences of the alpha 1-adrenergic receptor determine the selectivity of coupling to phosphatidylinositol hydrolysis. 
  • Discs of mammalian rod photoreceptors form through the membrane evagination mechanism. 
  • Disease mechanisms revealed by transcription profiling in SOD1-G93A transgenic mouse spinal cord. 
  • Disease progression in iridocorneal angle tissues of BMP2-induced ocular hypertensive mice with optical coherence tomography. 
  • Disease-causing mutations in parkin impair mitochondrial ubiquitination, aggregation, and HDAC6-dependent mitophagy. 
  • Dishevelled 2 recruits beta-arrestin 2 to mediate Wnt5A-stimulated endocytosis of Frizzled 4. 
  • Disialoganglioside GD2 in human neuroectodermal tumor cell lines and gliomas. 
  • Disparate adjuvant properties among three formulations of "alum". 
  • Disparity in the kinetics of onset of hypermutation in immunoglobulin heavy and light chains. 
  • Display of cell surface sites for fibronectin assembly is modulated by cell adherence to (1)F3 and C-terminal modules of fibronectin. 
  • Disrupted Neuroglial Metabolic Coupling after Peripheral Surgery. 
  • Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice. 
  • Disrupted iron homeostasis causes dopaminergic neurodegeneration in mice. 
  • Disrupted junctional membrane complexes and hyperactive ryanodine receptors after acute junctophilin knockdown in mice. 
  • Disrupted motor learning and long-term synaptic plasticity in mice lacking NMDAR1 in the striatum. 
  • Disrupted signaling and inhibited regeneration in obese mice with fatty livers: implications for nonalcoholic fatty liver disease pathophysiology. 
  • Disruption at the PTCHD1 Locus on Xp22.11 in Autism spectrum disorder and intellectual disability. 
  • Disruption of Arp2/3 results in asymmetric structural plasticity of dendritic spines and progressive synaptic and behavioral abnormalities. 
  • Disruption of Bardet-Biedl syndrome ciliary proteins perturbs planar cell polarity in vertebrates. 
  • Disruption of ErbB receptor signaling in adult non-myelinating Schwann cells causes progressive sensory loss. 
  • Disruption of Fgf13 causes synaptic excitatory-inhibitory imbalance and genetic epilepsy and febrile seizures plus. 
  • Disruption of Gen1 Causes Congenital Anomalies of the Kidney and Urinary Tract in Mice. 
  • Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress. 
  • Disruption of Gpr45 causes reduced hypothalamic POMC expression and obesity. 
  • Disruption of Mekk2 in mice reveals an unexpected role for MEKK2 in modulating T-cell receptor signal transduction. 
  • Disruption of PAX6 function in mice homozygous for the Pax6Sey-1Neu mutation produces abnormalities in the early development and regionalization of the diencephalon. 
  • Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis. 
  • Disruption of a ciliary B9 protein complex causes Meckel syndrome. 
  • Disruption of a nonribosomal peptide synthetase in Aspergillus fumigatus eliminates gliotoxin production. 
  • Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele. 
  • Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration. 
  • Disruption of diacylglycerol metabolism impairs the induction of T cell anergy. 
  • Disruption of intrathymic CD4-Ia interactions on immature CD4+CD8+ thymocytes results in diminished TCR expression on mature CD8+ T cell progeny. 
  • Disruption of leptin signaling contributes to cardiac hypertrophy independently of body weight in mice. 
  • Disruption of mindin exacerbates cardiac hypertrophy and fibrosis. 
  • Disruption of mitotic arrest precedes precocious differentiation and transdifferentiation of pregranulosa cells in the perinatal Wnt4 mutant ovary. 
  • Disruption of testis cords by cyclopamine or forskolin reveals independent cellular pathways in testis organogenesis. 
  • Disruption of the Ang II type 1 receptor promotes longevity in mice. 
  • Disruption of the expression of the proprotein convertase PC7 reduces BDNF production and affects learning and memory in mice. 
  • Disruption of the genomic imprint in trans with homologous recombination at Snrpn in ES cells. 
  • Disruption of the mouse Rce1 gene results in defective Ras processing and mislocalization of Ras within cells. 
  • Disruption of the mouse oestrogen receptor gene: resulting phenotypes and experimental findings. 
  • Disruption of the uncoupling protein-2 gene in mice reveals a role in immunity and reactive oxygen species production. 
  • Disruption of wave-associated Rac GTPase-activating protein (Wrp) leads to abnormal adult neural progenitor migration associated with hydrocephalus. 
  • Dissecting the in vivo metabolic potential of two human gut acetogens. 
  • Dissection of a quantitative trait locus for PR interval duration identifies Tnni3k as a novel modulator of cardiac conduction. 
  • Dissection of a type I interferon pathway in controlling bacterial intracellular infection in mice. 
  • Dissociation between vasospasm and functional improvement in a murine model of subarachnoid hemorrhage. 
  • Dissociation of frontotemporal dementia-related deficits and neuroinflammation in progranulin haploinsufficient mice. 
  • Dissociation of hepatic steatosis and insulin resistance in mice overexpressing DGAT in the liver. 
  • Distinct CD4+ helper T cells involved in primary and secondary responses to infection. 
  • Distinct IL-2 receptor signaling pattern in CD4+CD25+ regulatory T cells. 
  • Distinct Kinase-Independent Role of RIPK3 in CD11c+ Mononuclear Phagocytes in Cytokine-Induced Tissue Repair. 
  • Distinct Nav1.7-dependent pain sensations require different sets of sensory and sympathetic neurons. 
  • Distinct Roles of Myosins in Aspergillus fumigatus Hyphal Growth and Pathogenesis. 
  • Distinct and atypical intrinsic and extrinsic cell death pathways between photoreceptor cell types upon specific ablation of Ranbp2 in cone photoreceptors. 
  • Distinct and overlapping sarcoma subtypes initiated from muscle stem and progenitor cells. 
  • Distinct ankyrin isoforms at neuron cell bodies and nodes of Ranvier resolved using erythrocyte ankyrin-deficient mice. 
  • Distinct contracted conformations of the Tcra/Tcrd locus during Tcra and Tcrd recombination. 
  • Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties. 
  • Distinct dendritic cell populations sequentially present antigen to CD4 T cells and stimulate different aspects of cell-mediated immunity. 
  • Distinct effects of tafazzin deletion in differentiated and undifferentiated mitochondria. 
  • Distinct electric potentials in soma and neurite membranes. 
  • Distinct function of estrogen receptor α in smooth muscle and fibroblast cells in prostate development. 
  • Distinct gene expression phenotypes of cells lacking Rb and Rb family members. 
  • Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. 
  • Distinct granuloma responses in C57BL/6J and BALB/cByJ mice in response to pristane. 
  • Distinct hematopoietic progenitor compartments are delineated by the expression of aldehyde dehydrogenase and CD34. 
  • Distinct innate responses are induced by attenuated Salmonella enterica serovar Typhimurium mutants. 
  • Distinct mesodermal signals, including BMPs from the septum transversum mesenchyme, are required in combination for hepatogenesis from the endoderm. 
  • Distinct mouse coronary anatomy and myocardial infarction consequent to ligation. 
  • Distinct nuclear proteins competing for an overlapping sequence of cyclic adenosine monophosphate and negative regulatory elements regulate tissue-specific mouse renin gene expression. 
  • Distinct patterns of glycosylation of colligin, a collagen-binding glycoprotein, and SPARC (osteonectin), a secreted Ca2+-binding glycoprotein. Evidence for the localisation of colligin in the endoplasmic reticulum. 
  • Distinct patterns of tissue-specific lipid accumulation during the induction of insulin resistance in mice by high-fat feeding. 
  • Distinct properties and advantages of a novel peroxisome proliferator-activated protein [gamma] selective modulator. 
  • Distinct properties of cell-type-specific and shared transcription factor binding sites. 
  • Distinct requirements for Ras oncogenesis in human versus mouse cells. 
  • Distinct requirements for extra-embryonic and embryonic bone morphogenetic protein 4 in the formation of the node and primitive streak and coordination of left-right asymmetry in the mouse. 
  • Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. 
  • Distinct roles of E2F proteins in vascular smooth muscle cell proliferation and intimal hyperplasia. 
  • Distinct roles of matrix metalloproteases in the early- and late-phase development of neuropathic pain. 
  • Distinct roles of resident and nonresident macrophages in nonischemic cardiomyopathy. 
  • Distinct routes to metastasis: plasticity-dependent and plasticity-independent pathways. 
  • Distinct single amino acid replacements in the control of virulence regulator protein differentially impact streptococcal pathogenesis. 
  • Distinctions in the specificity of E2F function revealed by gene expression signatures. 
  • Distinctive adaptive response to repeated exposure to hydrogen peroxide associated with upregulation of DNA repair genes and cell cycle arrest. 
  • Distinctive patterns of hyperplasia in transgenic mice with mouse mammary tumor virus transforming growth factor-alpha. Characterization of mammary gland and skin proliferations. 
  • Distribution and tissue specificity of 4-aminobutyrate-2-oxoglutarate aminotransferase. 
  • Distribution of amyloid precursor protein and amyloid-beta in ocular hypertensive C57BL/6 mouse eyes. 
  • Distribution of binding sites for thromboxane A2 in the mouse kidney. 
  • Distribution of expression of 2AR (osteopontin) in the embryonic mouse inner ear revealed by in situ hybridisation. 
  • Distribution of the tight junction proteins ZO-1, occludin, and claudin-4, -8, and -12 in bladder epithelium. 
  • Distribution of, and immune response to, chicken anti-alpha Gal immunoglobulin Y antibodies in wild-type and alpha Gal knockout mice. 
  • Disulfide bond requirements for active Wnt ligands. 
  • Disulfiram inhibits activating transcription factor/cyclic AMP-responsive element binding protein and human melanoma growth in a metal-dependent manner in vitro, in mice and in a patient with metastatic disease. 
  • Disulfiram is a direct and potent inhibitor of human O6-methylguanine-DNA methyltransferase (MGMT) in brain tumor cells and mouse brain and markedly increases the alkylating DNA damage. 
  • Diurnal torpidity in the California pocket mouse. 
  • Diurnal variations in the toxicity and tissue levels of spermidine in mice. 
  • Divalent cation activation of galactosyltransferase in native mammary Golgi vesicles. 
  • Divalent metal transporter 1 regulates iron-mediated ROS and pancreatic β cell fate in response to cytokines. 
  • Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. 
  • Divergent functions of angiotensin II receptor isoforms in the brain. 
  • Divergent pathways mediate the induction of ANF transgenes in neonatal and hypertrophic ventricular myocardium. 
  • Divergent regulation of functionally distinct γ-tubulin complexes during differentiation. 
  • Divergent roles for RalA and RalB in malignant growth of human pancreatic carcinoma cells. 
  • Divergent vascular mechanisms downstream of Sry establish the arterial system in the XY gonad. 
  • Diverse endogenous light chains contribute to basement membrane reactivity in nonautoimmune mice transgenic for an anti-laminin Ig heavy chain. 
  • Diverse gap junctions modulate distinct mechanisms for fiber cell formation during lens development and cataractogenesis. 
  • Diverse genetic-driven immune landscapes dictate tumor progression through distinct mechanisms. 
  • Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses. 
  • Diversity-oriented synthesis yields novel multistage antimalarial inhibitors. 
  • Division of labour between Myc and G1 cyclins in cell cycle commitment and pace control. 
  • Dlg5 regulates dendritic spine formation and synaptogenesis by controlling subcellular N-cadherin localization. 
  • Dll4 Inhibition plus Aflibercept Markedly Reduces Ovarian Tumor Growth. 
  • Do Surface Porosity and Pore Size Influence Mechanical Properties and Cellular Response to PEEK? 
  • Do antagonists of pancreatic cholecystokinin receptors interact with central nervous system cholecystokinin receptors? 
  • Do germinal centers have a role in the generation of lymphomas? 
  • Docetaxel enhances tumor radioresponse in vivo. 
  • Does the intestinal microflora synthesize pyrroloquinoline quinone? 
  • Domains of the adenovirus E1A protein required for oncogenic activity are also required for dissociation of E2F transcription factor complexes. 
  • Dominant-negative mutants of Grb2 induced reversal of the transformed phenotypes caused by the point mutation-activated rat HER-2/Neu. 
  • Donor-derived regulatory B cells are important for suppression of murine sclerodermatous chronic graft-versus-host disease. 
  • Donor-derived, tolerogenic dendritic cells suppress immune rejection in the indirect allosensitization-dominant setting of corneal transplantation. 
  • Donor-specific CD8+ Foxp3+ T cells protect skin allografts and facilitate induction of conventional CD4+ Foxp3+ regulatory T cells. 
  • Dopamine D2 receptor relies upon PPM/PP2C protein phosphatases to dephosphorylate huntingtin protein. 
  • Dopamine and α-synuclein dysfunction in Smad3 null mice. 
  • Dopamine autoreceptor regulation of release and uptake in mouse brain slices in the absence of D(3) receptors. 
  • Dopamine enhances motor and neuropathological consequences of polyglutamine expanded huntingtin. 
  • Dopamine levels modulate the updating of tastant values. 
  • Dopamine neuronal transport kinetics and effects of amphetamine. 
  • Dopamine receptors: from structure to function. 
  • Dopamine tone regulates D1 receptor trafficking and delivery in striatal neurons in dopamine transporter-deficient mice. 
  • Dopamine transporter expression confers cytotoxicity to low doses of the parkinsonism-inducing neurotoxin 1-methyl-4-phenylpyridinium. 
  • Dopamine transporter is required for in vivo MPTP neurotoxicity: evidence from mice lacking the transporter. 
  • Dopamine transporter mutant mice in experimental neuropharmacology. 
  • Dopamine transporter-dependent and -independent actions of trace amine beta-phenylethylamine. 
  • Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA Is Conveyed through Wide-Field Amacrine Cells. 
  • Dopamine-independent locomotor actions of amphetamines in a novel acute mouse model of Parkinson disease. 
  • Dopamine: from pharmacology to molecular biology and back. 
  • Dopaminergic control of corticostriatal long-term synaptic depression in medium spiny neurons is mediated by cholinergic interneurons. 
  • Dopaminergic control of sleep-wake states. 
  • Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. 
  • Dormant breast cancer micrometastases reside in specific bone marrow niches that regulate their transit to and from bone. 
  • Dorsalizing and neuralizing properties of Xdsh, a maternally expressed Xenopus homolog of dishevelled. 
  • Dose-dependent effect of melatonin on life span and spontaneous tumor incidence in female SHR mice. 
  • Dose-dependent restoration of dystrophin expression in cardiac muscle of dystrophic mice by systemically delivered morpholino. 
  • Dosimetry and radiographic analysis of 131I-labeled anti-tenascin 81C6 murine monoclonal antibody in newly diagnosed patients with malignant gliomas: a phase II study. 
  • Double genetic modification of adenovirus fiber with RGD polylysine motifs significantly enhances gene transfer to isolated human pancreatic islets. 
  • Double-illumination photoacoustic microscopy. 
  • Doublecortin-Like Kinases Promote Neuronal Survival and Induce Growth Cone Reformation via Distinct Mechanisms. 
  • Down regulation of macrophage mannose/N-acetylglucosamine receptors by elevated glucose concentrations. 
  • Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis. 
  • Down-regulation of cathepsin B expression impairs the invasive and tumorigenic potential of human glioblastoma cells. 
  • Down-regulation of parkin protein in transient focal cerebral ischemia: A link between stroke and degenerative disease? 
  • Down-regulation of statin, a nonproliferation-specific nuclear protein, and up-regulation of c-myc after initiation of programmed cell death in mouse fibroblasts. 
  • Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation. 
  • Downregulation of NR3A-containing NMDARs is required for synapse maturation and memory consolidation. 
  • Downregulation of T cell receptor expression by CD8(+) lymphocytes in kidney allografts. 
  • Downregulation of adipose glutathione S-transferase A4 leads to increased protein carbonylation, oxidative stress, and mitochondrial dysfunction. 
  • Downregulation of carnitine acyl-carnitine translocase by miRNAs 132 and 212 amplifies glucose-stimulated insulin secretion. 
  • Downregulation of hepatic betaine:homocysteine methyltransferase (BHMT) expression in taurine-deficient mice is reversed by taurine supplementation in vivo. 
  • Downregulation of microglial activation by apolipoprotein E and apoE-mimetic peptides. 
  • Doxorubicin-conjugated chimeric polypeptide nanoparticles that respond to mild hyperthermia. 
  • Doxorubicin-conjugated polypeptide nanoparticles inhibit metastasis in two murine models of carcinoma. 
  • Dramatically different phenotypes in mouse models of human Tay-Sachs and Sandhoff diseases. 
  • Drd1a-tdTomato BAC transgenic mice for simultaneous visualization of medium spiny neurons in the direct and indirect pathways of the basal ganglia. 
  • Driving an improved CAR for cancer immunotherapy. 
  • Drug targeting using thermally responsive polymers and local hyperthermia. 
  • Drugs derived from cannabinoids. 2. Basic esters of nitrogen and carbocyclic analogs. 
  • Drugs derived from cannabinoids. 4. Effect of alkyl substitution in sulfur and carbocyclic analogs. 
  • Dual Metronomic Chemotherapy with Nab-Paclitaxel and Topotecan Has Potent Antiangiogenic Activity in Ovarian Cancer. 
  • Dual actions of S-nitrosylated derivative of vasoactive intestinal peptide as a vasoactive intestinal peptide-like mediator and a nitric oxide carrier. 
  • Dual control of dopamine synthesis and release by presynaptic and postsynaptic dopamine D2 receptors. 
  • Dual function of Bmpr1a signaling in restricting preosteoblast proliferation and stimulating osteoblast activity in mouse. 
  • Dual inhibition of beta-adrenergic and angiotensin II receptors by a single antagonist: a functional role for receptor-receptor interaction in vivo. 
  • Dual inhibition of epidermal growth factor receptor and vascular endothelial growth factor receptor phosphorylation by AEE788 reduces growth and metastasis of human colon carcinoma in an orthotopic nude mouse model. 
  • Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants. 
  • Dual labeling of the fibronectin matrix and actin cytoskeleton with green fluorescent protein variants. 
  • Dual modulation of cell survival and cell death by beta(2)-adrenergic signaling in adult mouse cardiac myocytes. 
  • Dual protein farnesyltransferase-geranylgeranyltransferase-I inhibitors as potential cancer chemotherapeutic agents. 
  • Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity. 
  • Dual roles of modulatory calcineurin-interacting protein 1 in cardiac hypertrophy. 
  • Dual roles of the C2B domain of synaptotagmin I in synchronizing Ca2+-dependent neurotransmitter release. 
  • Dual stem loops within the poliovirus internal ribosomal entry site control neurovirulence. 
  • Dual targeting of the thioredoxin and glutathione systems in cancer and HIV. 
  • Dual-Energy CT Imaging of Tumor Liposome Delivery After Gold Nanoparticle-Augmented Radiation Therapy. 
  • Dual-energy computed tomography imaging of atherosclerotic plaques in a mouse model using a liposomal-iodine nanoparticle contrast agent. 
  • Dual-energy micro-CT functional imaging of primary lung cancer in mice using gold and iodine nanoparticle contrast agents: a validation study. 
  • Dual-energy micro-CT of the rodent lung. 
  • Dual-energy micro-computed tomography imaging of radiation-induced vascular changes in primary mouse sarcomas. 
  • Dual-mode IVUS transducer for image-guided brain therapy: preliminary experiments. 
  • Dual-wavelength ratiometric fluorescence measurement of the membrane dipole potential. 
  • Duchenne muscular dystrophy involving translocation of the dmd gene next to ribosomal RNA genes. 
  • Duration and intensity of NF-kappaB activity determine the severity of endotoxin-induced acute lung injury. 
  • Duration of nuclear NF-kappaB action regulated by reversible acetylation. 
  • Dusp3 and Psme3 are associated with murine susceptibility to Staphylococcus aureus infection and human sepsis. 
  • Dynamic Remodeling of Pericytes In Vivo Maintains Capillary Coverage in the Adult Mouse Brain. 
  • Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. 
  • Dynamic and redundant regulation of LRRK2 and LRRK1 expression. 
  • Dynamic antibody-binding properties in the pathogenesis of HIT. 
  • Dynamic changes in the dendritic geometry of individual neurons visualized over periods of up to three months in the superior cervical ganglion of living mice. 
  • Dynamic contrast-enhanced MR microscopy identifies regions of therapeutic response in a preclinical model of colorectal adenocarcinoma. 
  • Dynamic contrast-enhanced quantitative susceptibility mapping with ultrashort echo time MRI for evaluating renal function. 
  • Dynamic denitrosylation via S-nitrosoglutathione reductase regulates cardiovascular function. 
  • Dynamic exchange at regulatory elements during chromatin remodeling underlies assisted loading mechanism. 
  • Dynamic fractal signature dissimilarity analysis for therapeutic response assessment using dynamic contrast-enhanced MRI. 
  • Dynamic mRNA Transport and Local Translation in Radial Glial Progenitors of the Developing Brain. 
  • Dynamic microRNA gene transcription and processing during T cell development. 
  • Dynamic patterns of retinoic acid synthesis and response in the developing mammalian heart. 
  • Dynamic regulation of sarcoplasmic reticulum Ca(2+) stores by stromal interaction molecule 1 and sarcolipin during muscle differentiation. 
  • Dynamic reorganization of striatal circuits during the acquisition and consolidation of a skill. 
  • Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration. 
  • Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure. 
  • Dysfunctional T cell metabolism in the tumor microenvironment. 
  • Dysregulated autophagy in the RPE is associated with increased susceptibility to oxidative stress and AMD. 
  • Dysregulation of C/EBPalpha by mutant Huntingtin causes the urea cycle deficiency in Huntington's disease. 
  • Dysregulation of dopamine transporters via dopamine D2 autoreceptors triggers anomalous dopamine efflux associated with attention-deficit hyperactivity disorder. 
  • Dysregulation of hedgehog signalling predisposes to synovial chondromatosis. 
  • Dysregulation of mitochondrial dynamics proteins are a targetable feature of human tumors. 
  • Dysregulation of multiple facets of glycogen metabolism in a murine model of Pompe disease. 
  • Dysregulation of the Hedgehog pathway in human hepatocarcinogenesis. 
  • Dysregulation of the mTOR pathway secondary to mutations or a hostile microenvironment contributes to cancer and poor wound healing. 
  • Dystonia and cerebellar atrophy in Cacna1a null mice lacking P/Q calcium channel activity. 
  • E protein transcription factors are required for the development of CD4(+) lineage T cells. 
  • E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene. 
  • E-cadherin is involved in the intrahepatic metastasis of hepatocellular carcinoma. 
  • E-cadherin polarity is determined by a multifunction motif mediating lateral membrane retention through ankyrin-G and apical-lateral transcytosis through clathrin. 
  • E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation. 
  • E2-induced degradation of uterine insulin receptor substrate-2: requirement for an IGF-I-stimulated, proteasome-dependent pathway. 
  • E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression. 
  • E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells. 
  • E2A promotes the survival of precursor and mature B lymphocytes. 
  • E2F4 and E2F5 play an essential role in pocket protein-mediated G1 control. 
  • E6AP is required for replicative and oncogene-induced senescence in mouse embryo fibroblasts. 
  • E6AP promotes the degradation of the PML tumor suppressor. 
  • E6AP ubiquitin ligase regulates PML-induced senescence in Myc-driven lymphomagenesis. 
  • EAG2 potassium channel with evolutionarily conserved function as a brain tumor target. 
  • EBV latent membrane protein 2A induces autoreactive B cell activation and TLR hypersensitivity. 
  • ECDI-fixed allogeneic splenocytes induce donor-specific tolerance for long-term survival of islet transplants via two distinct mechanisms. 
  • EGF promotes mammalian cell growth by suppressing cellular senescence. 
  • EGFRvIII and c-Met pathway inhibitors synergize against PTEN-null/EGFRvIII+ glioblastoma xenografts. 
  • EGFRvIII mCAR-modified T-cell therapy cures mice with established intracerebral glioma and generates host immunity against tumor-antigen loss. 
  • EGFRvIII-specific chimeric antigen receptor T cells migrate to and kill tumor deposits infiltrating the brain parenchyma in an invasive xenograft model of glioblastoma. 
  • EGFRvIII-targeted immunotoxin induces antitumor immunity that is inhibited in the absence of CD4+ and CD8+ T cells. 
  • EIF4A3 deficient human iPSCs and mouse models demonstrate neural crest defects that underlie Richieri-Costa-Pereira syndrome. 
  • EJ-Ras inhibits phospholipase C gamma 1 but not actin polymerization induced by platelet-derived growth factor-BB via phosphatidylinositol 3-kinase. 
  • EL-4 metastases in spleen and bone marrow suppress the NK activity generated in these organs. 
  • ELAV protein HuA (HuR) can redistribute between nucleus and cytoplasm and is upregulated during serum stimulation and T cell activation. 
  • ELF3 is a repressor of androgen receptor action in prostate cancer cells. 
  • ELR+ CXC chemokines and oncogenic Ras-mediated tumorigenesis. 
  • EM703 improves bleomycin-induced pulmonary fibrosis in mice by the inhibition of TGF-beta signaling in lung fibroblasts. 
  • ENU mutagenesis identifies mice with cardiac fibrosis and hepatic steatosis caused by a mutation in the mitochondrial trifunctional protein beta-subunit. 
  • ENU mutagenesis identifies mice with mitochondrial branched-chain aminotransferase deficiency resembling human maple syrup urine disease. 
  • ENaC- and CFTR-dependent ion and fluid transport in mammary epithelia. 
  • EP24.15 interacts with the angiotensin II type I receptor and bradykinin B2 receptor. 
  • ER stress modulates cellular metabolism. 
  • ERAAP synergizes with MHC class I molecules to make the final cut in the antigenic peptide precursors in the endoplasmic reticulum. 
  • ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration. 
  • ERRgamma regulates cardiac, gastric, and renal potassium homeostasis. 
  • ETS transcription factors regulate an enhancer activity in the third intron of TNF-alpha. 
  • EXT1 regulates chondrocyte proliferation and differentiation during endochondral bone development. 
  • Early B-cell activation after West Nile virus infection requires alpha/beta interferon but not antigen receptor signaling. 
  • Early fetal hypoxia leads to growth restriction and myocardial thinning. 
  • Early growth response 1 and NF-ATc1 act in concert to promote thymocyte development beyond the beta-selection checkpoint. 
  • Early growth response gene 1-mediated apoptosis is essential for transforming growth factor beta1-induced pulmonary fibrosis. 
  • Early induction of oxidative stress in mouse model of Alzheimer disease with reduced mitochondrial superoxide dismutase activity. 
  • Early mitochondrial calcium defects in Huntington's disease are a direct effect of polyglutamines. 
  • Early photon tomography allows fluorescence detection of lung carcinomas and disease progression in mice in vivo. 
  • Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD. 
  • Early, sustained efficacy of adeno-associated virus vector-mediated gene therapy in glycogen storage disease type Ia. 
  • Early-Life Intranasal Colonization with Nontypeable Haemophilus influenzae Exacerbates Juvenile Airway Disease in Mice. 
  • Early-onset degeneration of the intervertebral disc and vertebral end plate in mice deficient in type IX collagen. 
  • Ecdysone-inducible gene expression in mammalian cells and transgenic mice. 
  • Echocardiographically detected myocardial infarction in the mouse. 
  • Ecsit is required for Bmp signaling and mesoderm formation during mouse embryogenesis. 
  • Ectopic Expression of Interferon Regulatory Factor-1 Promotes Human Breast Cancer Cell Death and Results in Reduced Expression of Survivin 
  • Ectopic Expression of Retrotransposon-Derived PEG11/RTL1 Contributes to the Callipyge Muscular Hypertrophy. 
  • Ectopic expression of DLK1 protein in skeletal muscle of padumnal heterozygotes causes the callipyge phenotype. 
  • Ectopic expression of Hel-N1, an RNA-binding protein, increases glucose transporter (GLUT1) expression in 3T3-L1 adipocytes. 
  • Ectopic lipid deposition and the metabolic profile of skeletal muscle in ovariectomized mice. 
  • Ectopic myelinating oligodendrocytes in the dorsal spinal cord as a consequence of altered semaphorin 6D signaling inhibit synapse formation. 
  • Ectopic overexpression of Sonic Hedgehog (Shh) induces stromal expansion and metaplasia in the adult murine pancreas. 
  • Ectopic synaptogenesis in the mammalian retina caused by rod photoreceptor-specific mutations. 
  • Editing out five Serpina1 paralogs to create a mouse model of genetic emphysema. 
  • Effect of Anti-C5a Therapy in a Murine Model of Early/Intermediate Dry Age-Related Macular Degeneration. 
  • Effect of CXCL-1/KC production in high risk vascularized corneal allografts on T cell recruitment and graft rejection. 
  • Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. 
  • Effect of Human Genetic Variability on Gene Expression in Dorsal Root Ganglia and Association with Pain Phenotypes. 
  • Effect of IGFBP-3 on IGF- and IGF-analogue-induced insulin-like growth factor-I receptor (IGFIR) signalling. 
  • Effect of IL-1 on experimental bone/bone-marrow metastases. 
  • Effect of Steel factor and leukaemia inhibitory factor on murine primordial germ cells in culture. 
  • Effect of Trichodesma indicum extract on cough reflex induced by sulphur dioxide in mice. 
  • Effect of a metalloporphyrin antioxidant (MnTE-2-PyP) on the response of a mouse prostate cancer model to radiation. 
  • Effect of a purified diet on dystrophic cardiac calcinosis in mice. 
  • Effect of adriamycin and Corynebacterium parvum in tumor-bearing mice: modulation of response to sheep red blood cells. 
  • Effect of aerobic exercise on tumor physiology in an animal model of human breast cancer. 
  • Effect of altering dietary omega-6/omega-3 fatty acid ratios on prostate cancer membrane composition, cyclooxygenase-2, and prostaglandin E2. 
  • Effect of anti-CD4 antibody treatment on inflammatory arthritis in MRL-lpr/lpr mice. 
  • Effect of antidepressant drugs in mice lacking the norepinephrine transporter. 
  • Effect of asymmetric dimethylarginine on osteoblastic differentiation. 
  • Effect of basic fibroblast growth factor on angiogenesis and growth of isografted bone: quantitative in vitro-in vivo analysis in mice. 
  • Effect of bimatoprost on intraocular pressure in prostaglandin FP receptor knockout mice. 
  • Effect of bismuth salts on systemic and mucosal immune responses to orally administered cholera toxin. 
  • Effect of chemotherapy on uptake of alkali metals by experimental tumors. 
  • Effect of cocaine and cocaine congeners on veratridine-induced depolarization in mouse cerebrocortical synaptoneurosomes. 
  • Effect of compressive force on unbinding specific protein-ligand complexes with force spectroscopy. 
  • Effect of cyclic nucleotides on the induction of ornithine decarboxylase in BHK cells by serum and insulin. 
  • Effect of cyclic stretch on beta1D-integrin expression and activation of FAK and RhoA. 
  • Effect of cytofectins on the immune response of murine macrophages to mammalian DNA. 
  • Effect of delta-sleep inducing peptide-containing preparation Deltaran on biomarkers of aging, life span and spontaneous tumor incidence in female SHR mice. 
  • Effect of delta9-tetrahydrocannabinol on in vitro sensitization of mouse splenic lymphocytes. 
  • Effect of desiccating environmental stress versus systemic muscarinic AChR blockade on dry eye immunopathogenesis. 
  • Effect of ethanol on tumor necrosis factor signaling during liver regeneration. 
  • Effect of exposure to light-at-night on life span and spontaneous carcinogenesis in female CBA mice. 
  • Effect of fatty acids on insulin release: role of chain length and degree of unsaturation. 
  • Effect of flaxseed supplementation on prostatic carcinoma in transgenic mice. 
  • Effect of herpes simplex virus types 1 and 2 on surface expression of class I major histocompatibility complex antigens on infected cells. 
  • Effect of host microenvironment on the microcirculation of human colon adenocarcinoma. 
  • Effect of immunosuppressants on T-cell subsets observed in vivo using carboxy-fluorescein diacetate succinimidyl ester labeling. 
  • Effect of interferon on murine cytochrome P-450: effect of partially purified antigen-specific interferon-gamma. 
  • Effect of interferon on murine leukemia virus infection. II. Synthesis of viral components in exogenous infection. 
  • Effect of interferon-gamma and human alpha 2-macroglobulin on peritoneal macrophage morphology and Ia antigen expression. 
  • Effect of interleukin-1β on the expression of actin isoforms in cultured mouse astroglia. 
  • Effect of intermittent fasting on prostate cancer tumor growth in a mouse model. 
  • Effect of intermittent fasting with or without caloric restriction on prostate cancer growth and survival in SCID mice. 
  • Effect of intraocular gamma-interferon on immunoregulatory properties of iris and ciliary body cells. 
  • Effect of irradiation on cytokine production, MHC antigen expression, and vaccine potential of interleukin-2 and interferon-gamma gene-modified melanoma cells. 
  • Effect of isocaloric low fat diet on prostate cancer xenograft progression in a hormone deprivation model. 
  • Effect of isocaloric low-fat diet on prostate cancer xenograft progression to androgen independence. 
  • Effect of microRNA modulation on bioartificial muscle function. 
  • Effect of nandrolone decanoate administration on recovery from bupivacaine-induced muscle injury. 
  • Effect of neuronol on lifespan and development of spontaneous tumors in SAMP-1 mice with genetically accelerated aging. 
  • Effect of obesity on pulmonary inflammation induced by acute ozone exposure: role of interleukin-6. 
  • Effect of oxidative stress on homer scaffolding proteins. 
  • Effect of pain management on immunization efficacy in mice. 
  • Effect of pazopanib on tumor microenvironment and liposome delivery. 
  • Effect of poly(ethylene glycol) diacrylate concentration on network properties and in vivo response of poly(β-amino ester) networks. 
  • Effect of preexposure to ultrafine carbon black on respiratory syncytial virus infection in mice. 
  • Effect of propranolol as antiadhesive therapy in sickle cell disease. 
  • Effect of rapamycin alone and in combination with antiangiogenesis therapy in an orthotopic model of human pancreatic cancer. 
  • Effect of receptor number on desensitization of the mouse thromboxane receptor. 
  • Effect of sera from myasthenia gravis patients on acetylcholine receptors in myotube cultures. 
  • Effect of sex on the induction of anti-DNA antibodies in normal mice immunized with bacterial DNA. 
  • Effect of sulfur substitution for the noncarbonyl oxygen in hemicholinium-3 and acetyl-seco-hemicholinium-3. Synthesis, biological activity, and structure-toxicity relationships. 
  • Effect of synthetic thymic and pineal peptides on biomarkers of ageing, survival and spontaneous tumour incidence in female CBA mice. 
  • Effect of temperature on blood flow and hypoxic fraction in a murine fibrosarcoma. 
  • Effect of tenascin-C deficiency on chemically induced dermatitis in the mouse. 
  • Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans. 
  • Effect of the monoamine oxidase inhibitors clorgyline and pargyline on the hyperphagia of obese mice. 
  • Effect of the nitric oxide donor V-PYRRO/NO on portal pressure and sinusoidal dynamics in normal and cirrhotic mice. 
  • Effect of topical azithromycin on corneal innate immune responses. 
  • Effect of transient focal ischemia of mouse brain on energy state and NAD levels: no evidence that NAD depletion plays a major role in secondary disturbances of energy metabolism. 
  • Effect of transient hydronephrosis on subsequent compensatory renal growth. 
  • Effect of vasoactive intestinal peptide (VIP) on cytokine production and expression of VIP receptors in thymocyte subsets. 
  • Effect of virus infection on the inflammatory response. Depression of macrophage accumulation in influenza-infected mice. 
  • Effect os xid on anti-DNA B-cell precursors. 
  • Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor. 
  • Effective antibody therapy in herpes simplex virus ocular infection. Characterization of recipient immune response. 
  • Effective induction of protective systemic immunity with nasally administered vaccines adjuvanted with IL-1. 
  • Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer. 
  • Effective treatment of experimental DU-145 prostate cancers with targeted cytotoxic somatostatin analog AN-238. 
  • Effective treatment of models of multiple sclerosis by matrix metalloproteinase inhibitors. 
  • Effective tumor therapy with plasmid-encoded cytokines combined with in vivo electroporation. 
  • Effectiveness of combined interleukin 2 and B7.1 vaccination strategy is dependent on the sequence and order: a liposome-mediated gene therapy treatment for bladder cancer. 
  • Effector mechanisms of cytolytically activated macrophages. II. Secretion of a cytolytic factor by activated macrophages and its relationship to secreted neutral proteases. 
  • Effects and potential mechanisms of exercise training on cancer progression: a translational perspective. 
  • Effects of 10-hydroxycamptothecin, delivered from locally injectable poly(lactide-co-glycolide) microspheres, in a murine human oral squamous cell carcinoma regression model. 
  • Effects of 540C91 [(E)-3-[2-(4'-pyridyl)-vinyl]-1H-indole], an inhibitor of hepatic tryptophan dioxygenase, on brain quinolinic acid in mice. 
  • Effects of Acetaminophen on Oxidant and Irritant Respiratory Tract Responses to Environmental Tobacco Smoke in Female Mice. 
  • Effects of CKS-17, a synthetic retroviral envelope peptide, on cell-mediated immunity in vivo: immunosuppression, immunogenicity, and relation to immunosuppressive tumor products. 
  • Effects of CoA-independent transacylase inhibitors on the production of lipid inflammatory mediators. 
  • Effects of HMGB1 on in vitro responses of isolated muscle fibers and functional aspects in skeletal muscles of idiopathic inflammatory myopathies. 
  • Effects of HSP70.1/3 gene knockout on acute respiratory distress syndrome and the inflammatory response following sepsis. 
  • Effects of Helicobacter infection on research: the case for eradication of Helicobacter from rodent research colonies. 
  • Effects of IL-1 on hematopoietic progenitors after myelosuppressive chemoradiotherapy. 
  • Effects of MIP-1 alpha, MIP-3 alpha, and MIP-3 beta on the induction of HIV Gag-specific immune response with DNA vaccines. 
  • Effects of N-acetylcysteine in ozone-induced chronic obstructive pulmonary disease model. 
  • Effects of Space Flight on Mouse Liver versus Kidney: Gene Pathway Analyses. 
  • Effects of Y27632 on keratinocyte procurement and wound healing. 
  • Effects of a block in cysteine catabolism on energy balance and fat metabolism in mice. 
  • Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition. 
  • Effects of a manganese (III) porphyrin catalytic antioxidant in a mouse closed head injury model. 
  • Effects of acute tryptophan depletion on brain serotonin function and concentrations of dopamine and norepinephrine in C57BL/6J and BALB/cJ mice. 
  • Effects of antifungal agents and gamma interferon on macrophage cytotoxicity for fungi and tumor cells. 
  • Effects of bacterial DNA on cytokine production by (NZB/NZW)F1 mice. 
  • Effects of bacterial lipopolysaccharide on the hydrolysis of phosphatidylinositol-4,5-bisphosphate in murine peritoneal macrophages. 
  • Effects of burn injury, cold stress and cutaneous wound injury on the morphology and energy metabolism of murine brown adipose tissue (BAT) in vivo. 
  • Effects of calcium on ACTH stimulation of the adrenal: separation of hormone binding from adenyl cyclase activation. 
  • Effects of candesartan on angiotensin II-induced renal vasoconstriction in rats and mice. 
  • Effects of castration and chronic steroid treatments on hypothalamic gonadotropin-releasing hormone content and pituitary gonadotropins in male wild-type and estrogen receptor-alpha knockout mice. 
  • Effects of chondroitin sulfate proteoglycan 4 (NG2/CSPG4) on soft-tissue sarcoma growth depend on tumor developmental stage. 
  • Effects of chronic exposure to simulated microgravity on skeletal muscle cell proliferation and differentiation. 
  • Effects of classical and atypical antipsychotic drugs on isolation-induced aggression in male mice. 
  • Effects of corticosteroid treatment on airway inflammation, mechanics, and hyperpolarized ³He magnetic resonance imaging in an allergic mouse model. 
  • Effects of cyclosporine on human B-cell lymphoma development in vivo. 
  • Effects of exercise training on antitumor efficacy of doxorubicin in MDA-MB-231 breast cancer xenografts. 
  • Effects of eye removal at birth on histogenesis of the mouse superior colliculus: an autoradiographic analysis with tritiated thymidine. 
  • Effects of glutathione or polyamine depletion on in vivo thermosensitization. 
  • Effects of high-dose microbeam irradiation on tumor microvascular function and angiogenesis. 
  • Effects of hyperthermia and irradiation on the growth of mouse melanoma tumors following immunotherapy. 
  • Effects of iron depletion on CALM-AF10 leukemias. 
  • Effects of lactogen resistance and GH deficiency on mouse metabolism: pancreatic hormones, adipocytokines, and expression of adiponectin and insulin receptors. 
  • Effects of ligand and thyroid hormone receptor isoforms on hepatic gene expression profiles of thyroid hormone receptor knockout mice. 
  • Effects of maternal nicotine exposure on branching morphogenesis of mouse fetal lung: in vivo and in vitro studies. 
  • Effects of murine cytomegalovirus infection on the immune response to a tumor allograft. 
  • Effects of myocardial infarction on the distribution and transport of nutrients and oxygen in porcine myocardium. 
  • Effects of neoplasms on inflammation: depression of macrophage accumulation after tumor implantation. 
  • Effects of neuronal PIK3C3/Vps34 deletion on autophagy and beyond. 
  • Effects of nitric oxide releasing poly(vinyl alcohol) hydrogel dressings on dermal wound healing in diabetic mice. 
  • Effects of nitrogen mustard and splenectomy on mouse bone marrow colony formation in vitro. 
  • Effects of nociceptin (13-17) in pain modulation at supraspinal level in mice. 
  • Effects of oxidized LDL on mononuclear phagocytes: inhibition of induction of four inflammatory cytokine gene RNAs, release of NO, and cytolysis of tumor cells. 
  • Effects of oxygen on the metabolism of murine tumors using in vivo phosphorus-31 NMR. 
  • Effects of pentobarbital anesthesia on the energy metabolism of murine tumors studied by in vivo 31P nuclear magnetic resonance spectroscopy. 
  • Effects of periadolescent versus adult cocaine exposure on cocaine conditioned place preference and motor sensitization in mice. 
  • Effects of pimozide and penfluridol on the binding and endocytosis of alpha 2-macroglobulin-CH3NH2 by mouse peritoneal macrophages. 
  • Effects of progesterone and estradiol sex hormones on the release of microparticles by RAW 264.7 macrophages stimulated by Poly(I:C). 
  • Effects of rate, volume, and dose of intratumoral infusion on virus dissemination in local gene delivery. 
  • Effects of sazetidine-A, a selective α4β2* nicotinic receptor desensitizing agent, on body temperature regulation in mice and rats. 
  • Effects of simvastatin on retinal structure and function of a high-fat atherogenic mouse model of thickened Bruch's membrane. 
  • Effects of sodium fluoroacetate on the metabolism of N-acetylaspartate and aspartate in mouse brain. 
  • Effects of spaceflight on murine skeletal muscle gene expression. 
  • Effects of the kinase inhibitor sorafenib on heart, muscle, liver and plasma metabolism in vivo using non-targeted metabolomics analysis. 
  • Effects of the lpr mutation on elimination and inactivation of self-reactive B cells. 
  • Effects of the proteasome inhibitor PS-341 on apoptosis and angiogenesis in orthotopic human pancreatic tumor xenografts. 
  • Effects of the sazetidine-a family of compounds on the body temperature in wildtype, nicotinic receptor β2-/- and α7-/- mice. 
  • Effects of therapy on the 1H NMR spectrum of a human glioma line. 
  • Effects of topical and subconjunctival bevacizumab in high-risk corneal transplant survival. 
  • Effects of tumor growth on host defenses. 
  • Effects on blood pressure and exploratory behaviour of mice lacking angiotensin II type-2 receptor. 
  • Effects on hippocampus of lifelong absence of glucocorticoids in the pro-opiomelanocortin null mutant mouse reveal complex relationship between glucocorticoids and hippocampal structure and function. 
  • Efferent synapses return to inner hair cells in the aging cochlea. 
  • Efficacy and pharmacokinetic/pharmacodynamic evaluation of the Aurora kinase A inhibitor MLN8237 against preclinical models of pediatric cancer. 
  • Efficacy and toxicity of 9-beta-D-arabinofuranosylguanine (araG) as an agent to purge malignant T cells from murine bone marrow: application to an in vivo T-leukemia model. 
  • Efficacy of SERD/SERM Hybrid-CDK4/6 Inhibitor Combinations in Models of Endocrine Therapy-Resistant Breast Cancer. 
  • Efficacy of an abbreviated induction regimen of amphotericin B deoxycholate for cryptococcal meningoencephalitis: 3 days of therapy is equivalent to 14 days. 
  • Efficacy of an adeno-associated virus 8-pseudotyped vector in glycogen storage disease type II. 
  • Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans. 
  • Efficacy of colistin-impregnated beads to prevent multidrug-resistant A. baumannii implant-associated osteomyelitis. 
  • Efficacy of engineered FVIII-producing skeletal muscle enhanced by growth factor-releasing co-axial electrospun fibers. 
  • Efficacy of gene therapy for a prototypical lysosomal storage disease (GSD-II) is critically dependent on vector dose, transgene promoter, and the tissues targeted for vector transduction. 
  • Efficacy of helper-dependent adenovirus vector-mediated gene therapy in murine glycogen storage disease type Ia. 
  • Efficacy of liposomes and hyperthermia in a human tumor xenograft model: importance of triggered drug release. 
  • Efficacy of multiple administrations of a recombinant adenovirus expressing wild-type p53 in an immune-competent mouse tumor model. 
  • Efficacy of paclitaxel released from bio-adhesive polymer microspheres on model superficial bladder cancer. 
  • Efficacy of sunitinib and radiotherapy in genetically engineered mouse model of soft-tissue sarcoma. 
  • Efficacy of topoisomerase I inhibitors, topotecan and irinotecan, administered at low dose levels in protracted schedules to mice bearing xenografts of human tumors. 
  • Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. 
  • Efficient cross-priming of antiviral CD8+ T cells by antigen donor cells is GRP94 independent. 
  • Efficient dendritic cell priming of T lymphocytes depends on the extracellular matrix protein mindin. 
  • Efficient intratracheal delivery of airway epithelial cells in mice and pigs. 
  • Efficient lymphocyte migration across high endothelial venules of mouse Peyer's patches requires overlapping expression of L-selectin and beta7 integrin. 
  • Efficient purification and metabolite analysis of radiotracers using high-performance liquid chromatography and on-line solid-phase extraction. 
  • Efficient quantification of afferent cochlear ultrastructure using design-based stereology. 
  • Efficient transposition of the piggyBac (PB) transposon in mammalian cells and mice. 
  • Ehrlichiosis in children. 
  • Ejaculatory abnormalities in mice with targeted disruption of the gene for heme oxygenase-2. 
  • Elastic hydrogel as a sensor for detection of mechanical stress generated by single cells grown in three-dimensional environment. 
  • Electric field-mediated transport of plasmid DNA in tumor interstitium in vivo. 
  • Electric fields in tumors exposed to external voltage sources: implication for electric field-mediated drug and gene delivery. 
  • Electrical coupling mediates tunable low-frequency oscillations and resonance in the cerebellar Golgi cell network. 
  • Electromobility of plasmid DNA in tumor tissues during electric field-mediated gene delivery. 
  • Electron transport complex I is required for CD8+ T cell function. 
  • Electrophoretic analysis of four high molecular weight sialoglycoproteins produced by metastatic human colon carcinoma cells. 
  • Electrophysiological and biochemical characteristics of Gymnodinium breve toxins. 
  • Electrotonic influences on action potential duration dispersion in small hearts: a simulation study. 
  • Elementary Ca2+ signals through endothelial TRPV4 channels regulate vascular function. 
  • Elevated DNA polymerase alpha, DNA polymerase beta, and DNA topoisomerase II in a melphalan-resistant rhabdomyosarcoma xenograft that is cross-resistant to nitrosoureas and topotecan. 
  • Elevated beta-cell calmodulin produces a unique insulin secretory defect in transgenic mice. 
  • Elevated blood pressure and enhanced myocardial contractility in mice with severe IGF-1 deficiency. 
  • Elevated expression of PCGEM1, a prostate-specific gene with cell growth-promoting function, is associated with high-risk prostate cancer patients. 
  • Elevated expression of a subset of interferon inducible genes in primary bone marrow cells expressing p185 Bcr-Abl versus p210 Bcr-Abl by DNA microarray analysis. 
  • Elevated hepatocyte levels of the Forkhead box A2 (HNF-3beta) transcription factor cause postnatal steatosis and mitochondrial damage. 
  • Elevated intracellular calcium levels in cerebellar granule neurons of weaver mice. 
  • Elevation of susceptibility to ozone-induced acute tracheobronchial injury in transgenic mice deficient in Clara cell secretory protein. 
  • Eliciting and Analyzing Male Mouse Ultrasonic Vocalization (USV) Songs. 
  • Eliminating antibody polyreactivity through addition of N-linked glycosylation. 
  • Elimination of GRK2 from cholinergic neurons reduces behavioral sensitivity to muscarinic receptor activation. 
  • Elimination of mycoplasma from human B-lymphoblastoid cell lines. 
  • Elimination of the vesicular acetylcholine transporter in the striatum reveals regulation of behaviour by cholinergic-glutamatergic co-transmission. 
  • Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration. 
  • Elucidating the Candida albicans calcineurin signaling cascade controlling stress response and virulence. 
  • Elucidating the molecular mechanism of cardiac remodeling using a comparative genomic approach. 
  • Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor. 
  • Elucidation of The Behavioral Program and Neuronal Network Encoded by Dorsal Raphe Serotonergic Neurons. 
  • Elucidation of the transcription network governing mammalian sex determination by exploiting strain-specific susceptibility to sex reversal. 
  • Embryonic expression of Lim-1, the mouse homolog of Xenopus Xlim-1, suggests a role in lateral mesoderm differentiation and neurogenesis. 
  • Embryonic expression of a haematopoietic growth factor encoded by the Sl locus and the ligand for c-kit. 
  • Embryonic expression of mouse bone morphogenetic protein-1 (BMP-1), which is related to the Drosophila dorsoventral gene tolloid and encodes a putative astacin metalloendopeptidase. 
  • Embryonic germ cell lines and their derivation from mouse primordial germ cells. 
  • Embryonic germ cells are capable of adipogenic differentiation in vitro and in vivo. 
  • Embryonic mouse lung epithelial progenitor cells co-express immunohistochemical markers of diverse mature cell lineages. 
  • Emergence and pathogenicity of highly virulent Cryptococcus gattii genotypes in the northwest United States. 
  • Emergence of a seizure phenotype in aged apolipoprotein epsilon 4 targeted replacement mice. 
  • Emergence of anxiety-like behaviours in depressive-like Cpe(fat/fat) mice. 
  • Emerging Skin T-Cell Functions in Response to Environmental Insults. 
  • Emerging infectious diseases in an island ecosystem: the New Zealand perspective. 
  • Empirical evaluation of data transformations and ranking statistics for microarray analysis. 
  • En bloc substitution of the Src homology region 2 domain activates the transforming potential of the c-Abl protein tyrosine kinase. 
  • Enabling hyperpolarized (129) Xe MR spectroscopy and imaging of pulmonary gas transfer to the red blood cells in transgenic mice expressing human hemoglobin. 
  • Encapsulation of Adenovirus BMP2-Transduced Cells with PEGDA Hydrogels Allows Bone Formation in the Presence of Immune Response. 
  • Encapsulation of peptides in biodegradable microspheres prolongs their MHC class-I presentation by dendritic cells and macrophages in vitro. 
  • EndoU is a novel regulator of AICD during peripheral B cell selection. 
  • Endochondral bone formation from hydrogel carriers loaded with BMP2-transduced cells. 
  • Endocytosis of red blood cells or haemoglobin by activated macrophages inhibits their tumoricidal effect. 
  • Endogenous S-nitrosothiols protect against myocardial injury. 
  • Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production. 
  • Endogenous bone morphogenetic protein antagonists regulate mammalian neural crest generation and survival. 
  • Endogenous elevation of homocysteine induces retinal neuron death in the cystathionine-beta-synthase mutant mouse. 
  • Endogenous expression of transforming growth factor beta1 inhibits growth and tumorigenicity and enhances Fas-mediated apoptosis in a murine high-grade glioma model. 
  • Endogenous polymers of ADP-ribose are associated with the nuclear matrix. 
  • Endogenous production of extracellular adenosine by trabecular meshwork cells: potential role in outflow regulation. 
  • Endogenous tumor necrosis factor alpha (TNFalpha) requires TNF receptor type 2 to generate heat hyperalgesia in a mouse cancer model. 
  • Endoglin deficiency impairs stroke recovery. 
  • Endoglin interacts with VEGFR2 to promote angiogenesis. 
  • Endoglin promotes transforming growth factor beta-mediated Smad 1/5/8 signaling and inhibits endothelial cell migration through its association with GIPC. 
  • Endoglin regulates PI3-kinase/Akt trafficking and signaling to alter endothelial capillary stability during angiogenesis. 
  • Endoglin, an ancillary TGFbeta receptor, is required for extraembryonic angiogenesis and plays a key role in heart development. 
  • Endoplasmic reticulum stress, hepatocyte CD1d and NKT cell abnormalities in murine fatty livers. 
  • Endostatin inhibits the vascular endothelial growth factor-induced mobilization of endothelial progenitor cells. 
  • Endothelial Bmp4 is induced during arterial remodeling: effects on smooth muscle cell migration and proliferation. 
  • Endothelial SUR-8 acts in an ERK-independent pathway during atrioventricular cushion development. 
  • Endothelial and steroidogenic cell migration are regulated by WNT4 in the developing mammalian gonad. 
  • Endothelial antigen presentation: stimulation of previously activated but not naïve TCR-transgenic mouse T cells. 
  • Endothelial catabolism of extracellular adenosine during hypoxia: the role of surface adenosine deaminase and CD26. 
  • Endothelial cell death, angiogenesis, and microvascular function after castration in an androgen-dependent tumor: role of vascular endothelial growth factor. 
  • Endothelial cell surface ATP synthase-triggered caspase-apoptotic pathway is essential for k1-5-induced antiangiogenesis. 
  • Endothelial cells adhere to the RGD domain and the fibrinogen-like terminal knob of tenascin. 
  • Endothelial heparan sulfate controls chemokine presentation in recruitment of lymphocytes and dendritic cells to lymph nodes. 
  • Endothelial nitric oxide synthase stimulates aneurysm growth in aged mice. 
  • Endothelial progenitor cell infusion induces hematopoietic stem cell reconstitution in vivo. 
  • Endothelial selectins regulate skin wound healing in cooperation with L-selectin and ICAM-1. 
  • Endothelial, cardiac muscle and skeletal muscle exhibit different viscous and elastic properties as determined by atomic force microscopy. 
  • Endotoxin (LPS) stimulates in vitro migration of macrophages from LPS-resistant mice but not from LPS-sensitive mice. 
  • Endotoxin and NO induce MIP-1gamma gene transcription in ANA-1 murine macrophages. 
  • Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle. 
  • Endotoxin stress-response in cardiomyocytes: NF-kappaB activation and tumor necrosis factor-alpha expression. 
  • Endotoxin-mediated S-nitrosylation of p50 alters NF-kappa B-dependent gene transcription in ANA-1 murine macrophages. 
  • Endotoxin-mediated nitric oxide synthesis inhibits IL-1beta gene transcription in ANA-1 murine macrophages. 
  • Endotoxin-mediated synthesis of nitric oxide is dependent on Gq protein signal transduction. 
  • Endotoxin-stimulated nitric oxide production inhibits expression of cytochrome c oxidase in ANA-1 murine macrophages. 
  • Endurance exercise training increases adipose tissue glucocorticoid exposure: adaptations that facilitate lipolysis. 
  • Energy metabolic reprogramming in the hypertrophied and early stage failing heart: a multisystems approach. 
  • Energy metabolism in uncoupling protein 3 gene knockout mice. 
  • Enforced expression of FGF-7 promotes epithelial hyperplasia whereas a dominant negative FGFR2iiib promotes the emergence of neuroendocrine phenotype in prostate glands of transgenic mice. 
  • Enforcing order within a complex locus: current perspectives on the control of V(D)J recombination at the murine T-cell receptor alpha/delta locus. 
  • Engagement of Toll-like receptor-2 on cytotoxic T-lymphocytes occurs in vivo and augments antitumor activity. 
  • Engagement of the type I interferon receptor on dendritic cells inhibits T helper 17 cell development: role of intracellular osteopontin. 
  • Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions. 
  • Engineered leucine zippers show that hemiphosphorylated CREB complexes are transcriptionally active. 
  • Engineered microsphere contrast agents for optical coherence tomography. 
  • Engineered pluripotent mesenchymal cells integrate and differentiate in regenerating bone: a novel cell-mediated gene therapy. 
  • Engineered recombinant peanut protein and heat-killed Listeria monocytogenes coadministration protects against peanut-induced anaphylaxis in a murine model. 
  • Engineered skeletal muscle tissue networks with controllable architecture. 
  • Engineering DNA vaccines via co-delivery of co-stimulatory molecule genes. 
  • Engineering a BCR-ABL-activated caspase for the selective elimination of leukemic cells. 
  • Engineering and selection of shuffled AAV genomes: a new strategy for producing targeted biological nanoparticles. 
  • Engineering liver-detargeted AAV9 vectors for cardiac and musculoskeletal gene transfer. 
  • Engineering soluble major histocompatibility molecules: why and how. 
  • Engraftment of a galactose receptor footprint onto adeno-associated viral capsids improves transduction efficiency. 
  • Engraftment of human synovium into severe combined immune deficient mice. Migration of human peripheral blood T cells to engrafted human synovium and to mouse lymph nodes. 
  • Enhanced GLUT4-Dependent Glucose Transport Relieves Nutrient Stress in Obese Mice Through Changes in Lipid and Amino Acid Metabolism. 
  • Enhanced T cell responses due to diacylglycerol kinase zeta deficiency. 
  • Enhanced T2 contrast for MR histology of the mouse brain. 
  • Enhanced activation of human dendritic cells by inducible CD40 and Toll-like receptor-4 ligation. 
  • Enhanced allergen-induced airway inflammation in paucity of lymph node T cell (plt) mutant mice. 
  • Enhanced angiotensin II-induced cardiac and aortic remodeling in ACE2 knockout mice. 
  • Enhanced antibody responses to an HIV-1 membrane-proximal external region antigen in mice reconstituted with cultured lymphocytes. 
  • Enhanced avidity maturation of antibody to human immunodeficiency virus envelope: DNA vaccination with gp120-C3d fusion proteins. 
  • Enhanced binding and inertness to dehalogenation of alpha-melanotropic peptides labeled using N-succinimidyl 3-iodobenzoate. 
  • Enhanced calcium cycling and contractile function in transgenic hearts expressing constitutively active G alpha o* protein. 
  • Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2. 
  • Enhanced cardiac function in transgenic mice expressing a Ca(2+)-stimulated adenylyl cyclase. 
  • Enhanced central response to dehydration in mice lacking angiotensin AT(1a) receptors. 
  • Enhanced chondrogenic differentiation of embryonic stem cells by coculture with hepatic cells. 
  • Enhanced chondrogenic differentiation of murine embryonic stem cells in hydrogels with glucosamine. 
  • Enhanced contractility and decreased beta-adrenergic receptor kinase-1 in mice lacking endogenous norepinephrine and epinephrine. 
  • Enhanced delivery of a monoclonal antibody F(ab')2 fragment to subcutaneous human glioma xenografts using local hyperthermia. 
  • Enhanced differentiation of splenic plasma cells but diminished long-lived high-affinity bone marrow plasma cells in aged mice. 
  • Enhanced efficacy from gene therapy in Pompe disease using coreceptor blockade. 
  • Enhanced efficacy of an AAV vector encoding chimeric, highly secreted acid alpha-glucosidase in glycogen storage disease type II. 
  • Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles. 
  • Enhanced efficacy of enzyme replacement therapy in Pompe disease through mannose-6-phosphate receptor expression in skeletal muscle. 
  • Enhanced gene expression of systemically administered plasmid DNA in the liver with therapeutic ultrasound and microbubbles. 
  • Enhanced green fluorescent protein as a marker for localizing murine cytomegalovirus in acute and latent infection. 
  • Enhanced growth of small bowel in transgenic mice expressing human insulin-like growth factor I. 
  • Enhanced growth of small bowel in transgenic mice overexpressing bovine growth hormone. 
  • Enhanced in vivo cytotoxicity of recombinant human tumor necrosis factor with etoposide in human renal cell carcinoma. Evaluation in a pre-clinical model. 
  • Enhanced inflow and outflow rates despite lower IOP in bestrophin-2-deficient mice. 
  • Enhanced melphalan cytotoxicity following buthionine sulfoximine-mediated glutathione depletion in a human medulloblastoma xenograft in athymic mice. 
  • Enhanced morphine analgesia in mice lacking beta-arrestin 2. 
  • Enhanced myocardial function in transgenic mice overexpressing the beta 2-adrenergic receptor. 
  • Enhanced myocardial relaxation in vivo in transgenic mice overexpressing the beta2-adrenergic receptor is associated with reduced phospholamban protein. 
  • Enhanced neonatal Fc receptor function improves protection against primate SHIV infection. 
  • Enhanced oncolytic activity of vesicular stomatitis virus encoding SV5-F protein against prostate cancer. 
  • Enhanced outgrowth of EBV-transformed chronic lymphocytic leukemia B cells mediated by coculture with macrophage feeder cells. 
  • Enhanced pancreatic cancer gene therapy by combination of adenoviral vector expressing c-erb-B2 (Her-2/neu)-targeted immunotoxin with a replication-competent adenovirus or etoposide. 
  • Enhanced postischemic functional recovery in CYP2J2 transgenic hearts involves mitochondrial ATP-sensitive K+ channels and p42/p44 MAPK pathway. 
  • Enhanced priming of adaptive immunity by Mycobacterium smegmatis mutants with high-level protein secretion. 
  • Enhanced priming of adaptive immunity by a proapoptotic mutant of Mycobacterium tuberculosis. 
  • Enhanced production of superoxide anion by microglia from trisomy 16 mice. 
  • Enhanced refocusing of fat signals using optimized multipulse echo sequences. 
  • Enhanced renal leukotriene production in murine lupus: role of lipoxygenase metabolites. 
  • Enhanced response to enzyme replacement therapy in Pompe disease after the induction of immune tolerance. 
  • Enhanced rewarding properties of morphine, but not cocaine, in beta(arrestin)-2 knock-out mice. 
  • Enhanced subcortical spreading depression in familial hemiplegic migraine type 1 mutant mice. 
  • Enhanced therapeutic neovascularization by CD31-expressing cells and embryonic stem cell-derived endothelial cells engineered with chitosan hydrogel containing VEGF-releasing microtubes. 
  • Enhanced tonic GABA current in normotopic and hilar ectopic dentate granule cells after pilocarpine-induced status epilepticus. 
  • Enhanced transduction and improved photoreceptor survival of retinal degeneration by the combinatorial use of rAAV2 with a lower dose of adenovirus. 
  • Enhanced tumor localization and in vivo stability of a monoclonal antibody radioiodinated using N-succinimidyl 3-(tri-n-butylstannyl)benzoate. 
  • Enhanced tumour uptake and in vitro radiotoxicity of no-carrier-added [131I]meta-iodobenzylguanidine: implications for the targeted radiotherapy of neuroblastoma. 
  • Enhanced tumour uptake of radiolabelled antibodies by hyperthermia. Part II: Application of the thermal equivalency equation. 
  • Enhanced tumour uptake of radiolabelled antibodies by hyperthermia: Part I: Timing of injection relative to hyperthermia. 
  • Enhanced type 1 immunity after secondary viral challenge in mice primed as neonates. 
  • Enhancement of Outflow Facility in the Murine Eye by Targeting Selected Tight-Junctions of Schlemm's Canal Endothelia. 
  • Enhancement of anti-tumor immunity through local modulation of CTLA-4 and GITR by dendritic cells. 
  • Enhancement of antibodies to the human immunodeficiency virus type 1 envelope by using the molecular adjuvant C3d. 
  • Enhancement of cancer radiation therapy by use of adenovirus-mediated secretable glucose-regulated protein 94/gp96 expression. 
  • Enhancement of dopaminergic properties and protection mediated by neuronal activation of Ras in mouse ventral mesencephalic neurones. 
  • Enhancement of electric field-mediated gene delivery through pretreatment of tumors with a hyperosmotic mannitol solution. 
  • Enhancement of endocrine pancreatic secretions by essential fatty acids. 
  • Enhancement of experimental anaerobic infections by blood, hemoglobin, and hemostatic agents. 
  • Enhancement of irinotecan (CPT-11) activity against central nervous system tumor xenografts by alkylating agents. 
  • Enhancement of macrophage-mediated tumor cell killing by bacterial outer membrane proteins (porins). 
  • Enhancement of melphalan activity by inhibition of DNA polymerase-alpha and DNA polymerase-beta. 
  • Enhancement of melphalan-induced gastrointestinal toxicity in mice treated with regional hyperthermia and BSO-mediated glutathione depletion. 
  • Enhancement of nitrosourea activity in medulloblastoma and glioblastoma multiforme. 
  • Enhancement of paclitaxel-mediated cytotoxicity in lung cancer cells by 17-allylamino geldanamycin: in vitro and in vivo analysis. 
  • Enhancement of rAAV2-mediated transgene expression in retina cells in vitro and in vivo by coadministration of low-dose chemotherapeutic drugs. 
  • Enhancement of radiotherapy by hyperthermia-regulated gene therapy. 
  • Enhancer analysis of the mouse HNF-3 beta gene: regulatory elements for node/notochord and floor plate are independent and consist of multiple sub-elements. 
  • Enhancer control of local accessibility to V(D)J recombinase. 
  • Enhancer-blocking activity within the DNase I hypersensitive site 2 to 6 region between the TCR alpha and Dad1 genes. 
  • Enhancing Radiation Therapy Through Cherenkov Light-Activated Phototherapy. 
  • Enhancing efficacy of HIV gag DNA vaccine by local delivery of GM-CSF in murine and macaque models. 
  • Enhancing human islet transplantation by localized release of trophic factors from PLG scaffolds. 
  • Enhancing the immunostimulatory function of dendritic cells by transfection with mRNA encoding OX40 ligand. 
  • Enkephalin-dopamine interactions in behavioral arousal. 
  • Enrichment of endogenous fractalkine and anti-inflammatory cells via aptamer-functionalized hydrogels. 
  • Enterotoxigenic Escherichia coli vesicles target toxin delivery into mammalian cells. 
  • Environmental epigenomics and disease susceptibility. 
  • Environmental toxin-linked nonalcoholic steatohepatitis and hepatic metabolic reprogramming in obese mice. 
  • Environmentally relevant xenoestrogen tissue concentrations correlated to biological responses in mice. 
  • Enzymes that counteract nitrosative stress promote fungal virulence. 
  • Eosinophils Mediate Tissue Injury in the Autoimmune Skin Disease Bullous Pemphigoid. 
  • Eosinophils alter colonic epithelial barrier function: role for major basic protein. 
  • EphB2 receptor controls proliferation/migration dichotomy of glioblastoma by interacting with focal adhesion kinase. 
  • Epidermal Growth Factor and Granulocyte Colony Stimulating Factor Signaling Are Synergistic for Hematopoietic Regeneration. 
  • Epidermal growth factor alters metabolism of inositol lipids and activity of protein kinase C in mouse embryo palate mesenchyme cells. 
  • Epidermal growth factor augments adaptation following small bowel resection: optimal dosage, route, and timing of administration. 
  • Epidermal growth factor ligand-independent, unregulated, cell-transforming potential of a naturally occurring human mutant EGFRvIII gene. 
  • Epidermal growth factor receptor VIII peptide vaccination is efficacious against established intracerebral tumors. 
  • Epidermal growth factor receptor blockade with C225 plus gemcitabine results in regression of human pancreatic carcinoma growing orthotopically in nude mice by antiangiogenic mechanisms. 
  • Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. 
  • Epidermal growth factor receptor trans-activation mediates the tonic and fibrogenic effects of endothelin in the aortic wall of transgenic mice. 
  • Epidermal growth factor regulates hematopoietic regeneration after radiation injury. 
  • Epidermal growth factor replaces estrogen in the stimulation of female genital-tract growth and differentiation. 
  • Epigallocatechin-3-gallate (EGCG), a green tea polyphenol, stimulates hepatic autophagy and lipid clearance. 
  • Epigenetic Regulation of GDF2 Suppresses Anoikis in Ovarian and Breast Epithelia. 
  • Epigenetic changes during disease progression in a murine model of human chronic lymphocytic leukemia. 
  • Epigenetic instability of cytokine and transcription factor gene loci underlies plasticity of the T helper 17 cell lineage. 
  • Epigenetic propagation of CD4 expression is established by the Cd4 proximal enhancer in helper T cells. 
  • Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. 
  • Epigenetic regulation of gene expression: the effect of altered chromatin structure from yeast to mammals. 
  • Epigenetic regulation of the nitrosative stress response and intracellular macrophage survival by extraintestinal pathogenic Escherichia coli. 
  • Epigenetics and the regulation of stress vulnerability and resilience. 
  • Epigenomic comparison reveals activation of "seed" enhancers during transition from naive to primed pluripotency. 
  • Epilepsy genetics: an abundance of riches for biologists. 
  • Epinephrine-induced activation of LW-mediated sickle cell adhesion and vaso-occlusion in vivo. 
  • Epiregulin and EGFR interactions are involved in pain processing. 
  • Epithalon decelerates aging and suppresses development of breast adenocarcinomas in transgenic her-2/neu mice. 
  • Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. 
  • Epithelial progenitor cells of the embryonic lung and the role of microRNAs in their proliferation. 
  • Epithelial stem/progenitor cells in lung postnatal growth, maintenance, and repair. 
  • Epithelial-mesenchymal transition in prostate cancer: providing new targets for therapy. 
  • Epithelial-mesenchymal transitions and hepatocarcinogenesis. 
  • Epitope insertion into variable loops of HIV-1 gp120 as a potential means to improve immunogenicity of viral envelope protein. 
  • Epitope maps of the Escherichia coli heat-labile toxin B subunit for development of a synthetic oral vaccine. 
  • Epstein-Barr Viruses (EBVs) Deficient in EBV-Encoded RNAs Have Higher Levels of Latent Membrane Protein 2 RNA Expression in Lymphoblastoid Cell Lines and Efficiently Establish Persistent Infections in Humanized Mice. 
  • Epstein-Barr virus ensures B cell survival by uniquely modulating apoptosis at early and late times after infection. 
  • Epstein-Barr virus in synergy with tumor-promoter-induced malignant transformation of immortalized human epithelial cells. 
  • Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation. 
  • Eradication of melanoma pulmonary metastases by immunotherapy with tumor cells engineered to secrete interleukin-2 or gamma interferon. 
  • Eradication of solid human breast tumors in nude mice with an intravenously injected light-emitting oncolytic vaccinia virus. 
  • Erk2 phosphorylation of Drp1 promotes mitochondrial fission and MAPK-driven tumor growth. 
  • Erlotinib-mediated inhibition of EGFR signaling induces metabolic oxidative stress through NOX4. 
  • Errors in corticospinal axon guidance in mice lacking the neural cell adhesion molecule L1. 
  • Erythrocyte plasma membrane-bound ERK1/2 activation promotes ICAM-4-mediated sickle red cell adhesion to endothelium. 
  • Erythroid AP-1/NF-E2 elements vary in their response to NF-E2. 
  • Erythroid transcription factor NF-E2 is a haematopoietic-specific basic-leucine zipper protein. 
  • Erythroid-specific expression of human CD59 and transfer to vascular endothelial cells. 
  • Erythropoietic effects of 5-hydroxytryptamine. 
  • Erythropoietin Synthesis in Renal Myofibroblasts Is Restored by Activation of Hypoxia Signaling. 
  • Erythropoietin activates mitochondrial biogenesis and couples red cell mass to mitochondrial mass in the heart. 
  • Erythropoietin blockade inhibits the induction of tumor angiogenesis and progression. 
  • Erythropoietin hypersensitivity in primary familial and congenital polycythemia: role of tyrosines Y285 and Y344 in erythropoietin receptor cytoplasmic domain. 
  • Erythropoietin mediates terminal granulocytic differentiation of committed myeloid cells with ectopic erythropoietin receptor expression. 
  • Erythropoietin receptor contains both growth-promoting activity and differentiation-promoting activity. 
  • Erythropoietin receptor contributes to melanoma cell survival in vivo. 
  • Erythropoietin receptor signals both proliferation and erythroid-specific differentiation. 
  • Escape from tolerance in the human X-linked autoimmunity-allergic disregulation syndrome and the Scurfy mouse. 
  • Escherichia coli global gene expression in urine from women with urinary tract infection. 
  • Essential Role of mTORC1 in Self-Renewal of Murine Alveolar Macrophages. 
  • Essential and unexpected role of Yin Yang 1 to promote mesodermal cardiac differentiation. 
  • Essential role for NHERF in cAMP-mediated inhibition of the Na+-HCO3- co-transporter in BSC-1 cells. 
  • Essential role for Smad3 in regulating MCP-1 expression and vascular inflammation. 
  • Essential role for mammalian copper transporter Ctr1 in copper homeostasis and embryonic development. 
  • Essential role of AT1A receptor in the development of 2K1C hypertension. 
  • Essential role of ICAM-1/CD18 in mediating EPC recruitment, angiogenesis, and repair to the infarcted myocardium. 
  • Essential role of LAT in T cell development. 
  • Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia. 
  • Essential role of Smad3 in infarct healing and in the pathogenesis of cardiac remodeling. 
  • Essential role of beta-adrenergic receptor kinase 1 in cardiac development and function. 
  • Essential roles of S-nitrosothiols in vascular homeostasis and endotoxic shock. 
  • Establishing an accurate gas phase reference frequency to quantify 129 Xe chemical shifts in vivo. 
  • Establishment and characterization of a human prostatic carcinoma cell line (PC-3). 
  • Establishment and characterization of a new human prostatic carcinoma cell line (DuPro-1). 
  • Establishment and characterization of conditionally immortalized cells from the mouse urogenital ridge. 
  • Establishment and characterization of the human medulloblastoma cell line and transplantable xenograft D283 Med. 
  • Establishment of a melphalan-resistant rhabdomyosarcoma xenograft with cross-resistance to vincristine and enhanced sensitivity following buthionine sulfoximine-mediated glutathione depletion. 
  • Establishment of an index with increased sensitivity for assessing murine arthritis. 
  • Establishment of experimental eosinophilic vasculitis by IgE-mediated cutaneous reverse passive arthus reaction. 
  • Esterified Trehalose Analogues Protect Mammalian Cells from Heat Shock. 
  • Estimation of primate speciation dates using local molecular clocks. 
  • Estradiol enhances long term potentiation in hippocampal slices from aged apoE4-TR mice. 
  • Estradiol replacement enhances cocaine-stimulated locomotion in female C57BL/6 mice through estrogen receptor alpha. 
  • Estrogen metabolism within the lung and its modulation by tobacco smoke. 
  • Estrogen receptor beta protects against in vivo injury in RPE cells. 
  • Estrogen receptor gene disruption: molecular characterization and experimental and clinical phenotypes. 
  • Estrogen receptor-beta mediates male-female differences in the development of pressure overload hypertrophy. 
  • Estrogen stimulation and tamoxifen inhibition of leiomyoma cell growth in vitro and in vivo. 
  • Estrogen-related receptor-α is a metabolic regulator of effector T-cell activation and differentiation. 
  • Estrogen/antiestrogen responsiveness in an in vivo/in vitro model for myometrial tumorigenesis. 
  • Estrogenic activity of a dieldrin/toxaphene mixture in the mouse uterus, MCF-7 human breast cancer cells, and yeast-based estrogen receptor assays: no apparent synergism. 
  • Ethanol augments GABAergic transmission in the central amygdala via CRF1 receptors. 
  • Ethanol contributes to neurogenic pancreatitis by activation of TRPV1. 
  • Ethanol induces redox-sensitive cell-cycle inhibitors and inhibits liver regeneration after partial hepatectomy. 
  • Ethanol metabolism modifies hepatic protein acylation in mice. 
  • Ethanol, disulfiram, and pyrazole: effects on interferon production in mice. 
  • Ethanol-induced face-brain dysmorphology patterns are correlative and exposure-stage dependent. 
  • Ethylenecarbodiimide-fixed donor splenocyte infusions differentially target direct and indirect pathways of allorecognition for induction of transplant tolerance. 
  • Ethylenecarbodiimide-treated splenocytes carrying male CD4 epitopes confer histocompatibility Y chromosome antigen transplant protection by inhibiting CD154 upregulation. 
  • Etomoxir-induced PPARalpha-modulated enzymes protect during acute renal failure. 
  • Ets-1 and runx2 regulate transcription of a metastatic gene, osteopontin, in murine colorectal cancer cells. 
  • Eukaryotic transcription termination factor La mediates transcript release and facilitates reinitiation by RNA polymerase III. 
  • EuroPhenome: a repository for high-throughput mouse phenotyping data. 
  • Evaluation of 5-(2-(4-pyridinyl)vinyl)-6-chloro-3-(1-methyl-2-(S)-pyrrolidinylmethoxy)pyridine and its analogues as PET radioligands for imaging nicotinic acetylcholine receptors. 
  • Evaluation of Alternative In Vivo Drug Screening Methodology: A Single Mouse Analysis. 
  • Evaluation of Lipin 2 as a candidate gene for autosomal dominant 1 high-grade myopia. 
  • Evaluation of a digital microfluidic real-time PCR platform to detect DNA of Candida albicans in blood. 
  • Evaluation of a recombinant yeast cell estrogen screening assay. 
  • Evaluation of an anti-p185(HER2) (scFv-C(H)2-C(H)3)2 fragment following radioiodination using two different residualizing labels: SGMIB and IB-Mal-D-GEEEK. 
  • Evaluation of an improved fiberoptics luminescence skin monitor with background correction. 
  • Evaluation of an internalizing monoclonal antibody labeled using N-succinimidyl 3-[131I]iodo-4-phosphonomethylbenzoate ([131I]SIPMB), a negatively charged substituent bearing acylation agent. 
  • Evaluation of anti-podoplanin rat monoclonal antibody NZ-1 for targeting malignant gliomas. 
  • Evaluation of anti-tussive activity of Bergenia ciliata Sternb. rhizome extract in mice. 
  • Evaluation of antitussive potential of Jussiaea suffruticosa linn. extract in albino mice. 
  • Evaluation of complex inheritance involving the most common Bardet-Biedl syndrome locus (BBS1). 
  • Evaluation of host immune responses to pulmonary cryptococcosis using a temperature-sensitive C. neoformans calcineurin A mutant strain. 
  • Evaluation of humoral, mucosal, and cellular immune responses following co-immunization of HIV-1 Gag and Env proteins expressed by Newcastle disease virus. 
  • Evaluation of meta-[211At]astatobenzylguanidine in an athymic mouse human neuroblastoma xenograft model. 
  • Evaluation of monolayer, liquid, gelfoam sponge and artificial capillary culture systems for the study of hematopoiesis. 
  • Evaluation of new anticancer agents against human pancreatic carcinomas in nude mice. 
  • Evaluation of p-amidinophenyl esters as potential antithrombotic agents. 
  • Evaluation of penicillin and hyperbaric oxygen in the treatment of streptococcal myositis. 
  • Evaluation of psychopharmacological effects of Clerodendrum phlomidis Linn. extract. 
  • Evaluation of recombinant adenovirus vaccines based on glycoprotein D and truncated UL25 against herpes simplex virus type 2 in mice. 
  • Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse. 
  • Evaluation of the alpha(2A)-adrenergic receptor gene in a heritable form of temporal lobe epilepsy. 
  • Evaluation of the antioxidant peptide SS31 for treatment of burn-induced insulin resistance. 
  • Evaluation of the effect of transcytolemmal water exchange analysis for therapeutic response assessment using DCE-MRI: a comparison study. 
  • Evaluation of the pharmacological activities of RAD1901, a selective estrogen receptor degrader. 
  • Evaluation of the rapid plasma elimination of recombinant alpha 1-proteinase inhibitor: synthesis of polyethylene glycol conjugates with improved therapeutic potential. 
  • Evaluation of tumor microenvironment in an animal model using a nanoparticle contrast agent in computed tomography imaging. 
  • Evans blue dye-enhanced capillary-resolution photoacoustic microscopy in vivo. 
  • Evasion of immune responses to introduced human acid alpha-glucosidase by liver-restricted expression in glycogen storage disease type II. 
  • Evidence for Feedback Regulation Following Cholesterol Lowering Therapy in a Prostate Cancer Xenograft Model. 
  • Evidence for a common evolutionary origin of brain and pancreas cholecystokinin receptors. 
  • Evidence for a role of Met-HGF/SF during Ras-mediated tumorigenesis/metastasis. 
  • Evidence for a second alpha 2-macroglobulin receptor. 
  • Evidence for an alternative glycolytic pathway in rapidly proliferating cells. 
  • Evidence for an immune barrier after in utero hematopoietic-cell transplantation. 
  • Evidence for disruption of sphingolipid metabolism as a contributing factor in the toxicity and carcinogenicity of fumonisins. 
  • Evidence for epithelial-mesenchymal transitions in adult liver cells. 
  • Evidence for p53-mediated modulation of neuronal viability. 
  • Evidence for phenotypic plasticity in aggressive triple-negative breast cancer: human biology is recapitulated by a novel model system. 
  • Evidence for positive and negative regulatory elements in the 5'-flanking sequence of the mouse sparc (osteonectin) gene. 
  • Evidence for the existence of renin in the heart. 
  • Evidence for the involvement of the Gli gene family in embryonic mouse lung development. 
  • Evidence for the presence of the platelet-activating factor receptor in the CFW mouse preimplantation two-cell-stage embryo. 
  • Evidence for two cellular pathways of renin secretion by the mouse submandibular gland. 
  • Evidence for type II cells as cells of origin of K-Ras-induced distal lung adenocarcinoma. 
  • Evidence from molecular cloning that SPARC, a major product of mouse embryo parietal endoderm, is related to an endothelial cell 'culture shock' glycoprotein of Mr 43,000. 
  • Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis. 
  • Evidence that Gsta4 modifies susceptibility to skin tumor development in mice and humans. 
  • Evidence that Hensen's node is a site of retinoic acid synthesis. 
  • Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse. 
  • Evidence that SOX2 overexpression is oncogenic in the lung. 
  • Evidence that autocrine signaling through Bmpr1a regulates the proliferation, survival and morphogenetic behavior of distal lung epithelial cells. 
  • Evidence that haploinsufficiency of Ptch leads to medulloblastoma in mice. 
  • Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development. 
  • Evidence that the platinum-reactive methionyl residue of the alpha 2-macroglobulin receptor recognition site is not in the carboxyl-terminal receptor binding domain. 
  • Evidence that there is no direct correlation between alpha 2-adrenoceptor antagonism and inhibition of voltage-dependent sodium channels. 
  • Evidence-ranked motif identification. 
  • Evolution and development of the mammalian dentition: insights from the marsupial Monodelphis domestica. 
  • Evolution of the tenascin family--implications for function of the C-terminal fibrinogen-like domain. 
  • Evolutionary and ecological functional genomics. 
  • Evolutionary conservation of possible functional domains of the human and murine XIST genes. 
  • Ex Vivo and In Vivo Noninvasive Imaging of Epidermal Growth Factor Receptor Inhibition on Colon Tumorigenesis Using Activatable Near-Infrared Fluorescent Probes. 
  • Ex vivo culture rescues hematopoietic stem cells with long-term repopulating capacity following harvest from lethally irradiated mice. 
  • Ex vivo expansion of murine and human hematopoietic stem cells. 
  • Ex vivo glycan engineering of CD44 programs human multipotent mesenchymal stromal cell trafficking to bone. 
  • Ex vivo spermine dialdehyde treatment prevents lethal GVHD in a murine bone marrow transplantation model. 
  • Exaggerated peripheral responses to catecholamines contributes to stress-induced hyperglycemia in the ob/ob mouse. 
  • Examination of Msh6- and Msh3-deficient mice in class switching reveals overlapping and distinct roles of MutS homologues in antibody diversification. 
  • Exceptional aggressiveness of cerebral cavernous malformation disease associated with PDCD10 mutations. 
  • Excitatory but not inhibitory synaptic transmission is reduced in lethargic (Cacnb4(lh)) and tottering (Cacna1atg) mouse thalami. 
  • Exercise can prevent and reverse the severity of hypertrophic cardiomyopathy. 
  • Exercise induces hippocampal BDNF through a PGC-1α/FNDC5 pathway. 
  • Exercise modulation of the host-tumor interaction in an orthotopic model of murine prostate cancer. 
  • Exercise stimulates Pgc-1alpha transcription in skeletal muscle through activation of the p38 MAPK pathway. 
  • Exhausted CD8 T cells downregulate the IL-18 receptor and become unresponsive to inflammatory cytokines and bacterial co-infections. 
  • Exogenous pyruvate prevents stress-evoked suppression of mitogen-stimulated proliferation. 
  • Exome capture reveals ZNF423 and CEP164 mutations, linking renal ciliopathies to DNA damage response signaling. 
  • Exome-wide Association Study Identifies GREB1L Mutations in Congenital Kidney Malformations. 
  • Expanded Satellite Repeats Amplify a Discrete CENP-A Nucleosome Assembly Site on Chromosomes that Drive in Female Meiosis. 
  • Expanded breadth of the T-cell response to mosaic human immunodeficiency virus type 1 envelope DNA vaccination. 
  • Expanded polyglutamine domain proteins bind neurofilament and alter the neurofilament network. 
  • Expansion of engrafting human hematopoietic stem/progenitor cells in three-dimensional scaffolds with surface-immobilized fibronectin. 
  • Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain. 
  • Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor. 
  • Expansion/deletion of mature T cells exposed to endogenous superantigens in vivo. 
  • Experimental Models of Short Courses of Liposomal Amphotericin B for Induction Therapy for Cryptococcal Meningitis. 
  • Experimental autoimmune encephalomyelitis in mice lacking glial fibrillary acidic protein is characterized by a more severe clinical course and an infiltrative central nervous system lesion. 
  • Experimental chemotherapy of human medulloblastoma cell lines and transplantable xenografts with bifunctional alkylating agents. 
  • Experimental chemotherapy of human medulloblastoma with classical alkylators. 
  • Experimental effects of hyperbaric oxygen on selected clostridial species. II. In-vitro studies in mice. 
  • Experimental evaluation of rodent exclusion methods to reduce hantavirus transmission to residents in a Native American community in New Mexico. 
  • Experimental models of human carcinogenesis. 
  • Experimental study of the effect of diethylstilbestrol on the development of the human female reproductive tract. 
  • Experimental validation of an inverse fluorescence Monte Carlo model to extract concentrations of metabolically relevant fluorophores from turbid phantoms and a murine tumor model. 
  • Exploitation of macrophages as a replication niche by Legionella pneumophila: response. 
  • Exploiting innate immune cell activation of a copper-dependent antimicrobial agent during infection. 
  • Exploring the role of the beta-adrenergic receptor kinase in cardiac disease using gene-targeted mice. 
  • Exploring type I angiotensin (AT1) receptor functions through gene targeting. 
  • Exploring variation in binding of Protein A and Protein G to immunoglobulin type G by isothermal titration calorimetry. 
  • Exposing cardiomyocytes to subclinical concentrations of doxorubicin rapidly reduces their creatine transport. 
  • Exposure of cultured murine peritoneal macrophages to low concentrations of beryllium induces increases in intracellular calcium concentrations and stimulates DNA synthesis. 
  • Exposure of mice to topical bovine thrombin induces systemic autoimmunity. 
  • Exposure to a youthful circulaton rejuvenates bone repair through modulation of β-catenin. 
  • Exposure to hyperbaric oxygen not beneficial for murine tetanus. 
  • Exposure to hyperoxia induces p53 expression in mouse lung epithelium. 
  • Exposure to particulate hexavalent chromium exacerbates allergic asthma pathology. 
  • Expression analysis and mapping of the mouse and human transcriptional regulator CA150. 
  • Expression analysis of the T-cell-targeting chemokines CXCL9 and CXCL10 in mice and humans with endothelial infections caused by rickettsiae of the spotted fever group. 
  • Expression and Role of Voltage-Gated Sodium Channels in Human Dorsal Root Ganglion Neurons with Special Focus on Nav1.7, Species Differences, and Regulation by Paclitaxel. 
  • Expression and function of Fas on cells damaged by gamma-irradiation in B6 and B6/lpr mice. 
  • Expression and function of NPSR1/GPRA in the lung before and after induction of asthma-like disease. 
  • Expression and function of the gamma c subunit of the IL-2, IL-4, and IL-7 receptors. Distinct interaction of gamma c in the IL-4 receptor. 
  • Expression and functional analysis of Gm114, a putative mammalian ortholog of Drosophila bam. 
  • Expression and modification of Hox 2.1 protein in mouse embryos. 
  • Expression and modulation of RPE cell membrane complement regulatory proteins. 
  • Expression and regulation of calcium-independent protein kinase C in NG 108-15 cell differentiation. 
  • Expression and subcellular distribution of mouse cytochrome P1-450 mRNA as determined by molecular hybridization with cloned P1-450 DNA. 
  • Expression cloning of protein targets for 3-phosphorylated phosphoinositides. 
  • Expression cloning of type 2 angiotension II receptor reveals a unique class of seven-transmembrane receptors. 
  • Expression of A20 by dendritic cells preserves immune homeostasis and prevents colitis and spondyloarthritis. 
  • Expression of C3b receptors on human be cells and myelomonocytic cells but not natural killer cells. 
  • Expression of C3d receptors during human B cell differentiation: immunofluorescence analysis with the HB-5 monoclonal antibody. 
  • Expression of CXC chemokine receptor-4 enhances the pulmonary metastatic potential of murine B16 melanoma cells. 
  • Expression of Ca(2+)/calmodulin-dependent protein kinase IV (caMKIV) messenger RNA during murine embryogenesis. 
  • Expression of EGF receptor and transferrin by F9 and PC13 teratocarcinoma cells. 
  • Expression of Mls determinants in mice exhibiting the severe combined immunodeficiency (scid) mutation or X-linked immunodeficiency (xid) defect. 
  • Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression. 
  • Expression of Sry, the mouse sex determining gene. 
  • Expression of TGF-beta isoforms by Thy-1+ and Thy-1- pulmonary fibroblast subsets: evidence for TGF-beta as a regulator of IL-1-dependent stimulation of IL-6. 
  • Expression of TIMP in fetal and adult mouse tissues studied by in situ hybridization. 
  • Expression of a beta-adrenergic receptor kinase 1 inhibitor prevents the development of myocardial failure in gene-targeted mice. 
  • Expression of a candidate sex-determining gene during mouse testis differentiation. 
  • Expression of a constitutive form of calcium/calmodulin dependent protein kinase II leads to arrest of the cell cycle in G2. 
  • Expression of a highly conserved anti-DNA idiotype in normal and autoimmune mice. 
  • Expression of a murine cytomegalovirus early-late protein in "latently" infected mice. 
  • Expression of a peptide inhibitor of protein phosphatase 1 increases phosphorylation and activity of CREB in NIH 3T3 fibroblasts. 
  • Expression of an antisense transforming growth factor-beta1 transgene reduces tumorigenicity of EMT6 mammary tumor cells. 
  • Expression of c-fos in parietal endoderm, amnion and differentiating F9 teratocarcinoma cells. 
  • Expression of cadherin-11 delineates boundaries, neuromeres, and nuclei in the developing mouse brain. 
  • Expression of chimeric tRNA-driven antisense transcripts renders NIH 3T3 cells highly resistant to Moloney murine leukemia virus replication. 
  • Expression of constitutively active Raf-1 in the mitochondria restores antiapoptotic and leukemogenic potential of a transformation-deficient BCR/ABL mutant. 
  • Expression of cytokine mRNA in murine splenic dendritic cells and better induction of T cell-derived cytokines by dendritic cells than by macrophages during in vitro costimulation assay using specific antigens. 
  • Expression of extracellular glutathione peroxidase in human and mouse gastrointestinal tract. 
  • Expression of full-length and truncated dystrophin mini-genes in transgenic mdx mice. 
  • Expression of functional estrogen receptor beta in locus coeruleus-derived Cath.a cells. 
  • Expression of genes from the human active and inactive X chromosomes. 
  • Expression of glucokinase in cultured human muscle cells confers insulin-independent and glucose concentration-dependent increases in glucose disposal and storage. 
  • Expression of heme oxygenase-1 can determine cardiac xenograft survival. 
  • Expression of heterogeneous nuclear ribonucleoprotein A2/B1 changes with critical stages of mammalian lung development. 
  • Expression of high mobility group protein 1 in the sera of patients and mice with systemic lupus erythematosus. 
  • Expression of homeo box genes during mouse development: a review. 
  • Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice. 
  • Expression of mitofusin 2(R94Q) in a transgenic mouse leads to Charcot-Marie-Tooth neuropathy type 2A. 
  • Expression of murine leukemia virus structural antigens on the surface of chemically induced murine sarcomas. 
  • Expression of normal and novel glucokinase mRNAs in anterior pituitary and islet cells. 
  • Expression of recombinant human methylmalonyl-CoA mutase: in primary mut fibroblasts and Saccharomyces cerevisiae. 
  • Expression of stimulator of Fe transport is not enhanced in Hfe knockout mice. 
  • Expression of the 71 kDa dystrophin isoform (Dp71) evaluated by gene targeting. 
  • Expression of the AT2 receptor developmentally programs extracellular signal-regulated kinase activity and influences fetal vascular growth. 
  • Expression of the DMT1 (NRAMP2/DCT1) iron transporter in mice with genetic iron overload disorders. 
  • Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse. 
  • Expression of the homeobox genes Hox 2.1 and 2.6 during mouse development. 
  • Expression of the human poliovirus receptor/CD155 gene during development of the central nervous system: implications for the pathogenesis of poliomyelitis. 
  • Expression of the human poliovirus receptor/CD155 gene is activated by sonic hedgehog. 
  • Expression of the protein tyrosine phosphatase, phosphatase of regenerating liver 1, in the outer segments of primate cone photoreceptors. 
  • Expression of the transcription factor lung Krüppel-like factor is regulated by cytokines and correlates with survival of memory T cells in vitro and in vivo. 
  • Expression of tissue factor in tumor stroma correlates with progression to invasive human breast cancer: paracrine regulation by carcinoma cell-derived members of the transforming growth factor beta family. 
  • Expression of transforming growth factor beta 2 RNA during murine embryogenesis. 
  • Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells. 
  • Expression of tumor necrosis factor receptor-1 in arterial wall cells promotes atherosclerosis. 
  • Expression of v-Ha-ras driven by the calcitonin/calcitonin gene-related peptide promoter: a novel transgenic murine model for medullary thyroid carcinoma. 
  • Expression profiling of a transformed thymocyte cell line undergoing maturation in vitro identifies multiple genes involved in positive selection. 
  • Expression profiling of in vivo ductal carcinoma in situ progression models identified B cell lymphoma-9 as a molecular driver of breast cancer invasion. 
  • Expression, enzyme activity, and subcellular localization of mammalian target of rapamycin in insulin-responsive cells. 
  • Extending principles learned in model systems to clinical trials design. 
  • Extent of stimulation controls the formation of memory CD8 T cells. 
  • Extracellular caspase-6 drives murine inflammatory pain via microglial TNF-α secretion. 
  • Extracellular glutathione peroxidase (Gpx3) binds specifically to basement membranes of mouse renal cortex tubule cells. 
  • Extracellular matrix protein betaig-h3/TGFBI promotes metastasis of colon cancer by enhancing cell extravasation. 
  • Extracellular microRNAs activate nociceptor neurons to elicit pain via TLR7 and TRPA1. 
  • Extracellular phospholipase activity is a virulence factor for Cryptococcus neoformans. 
  • Extracellular signal-regulated kinase 5 (ERK5) mediates prolactin-stimulated adult neurogenesis in the subventricular zone and olfactory bulb. 
  • Extracellular superoxide dismutase deficiency worsens outcome from focal cerebral ischemia in the mouse. 
  • Extracellular superoxide dismutase in the airways of transgenic mice reduces inflammation and attenuates lung toxicity following hyperoxia. 
  • Extracellular superoxide dismutase inhibits inflammation by preventing oxidative fragmentation of hyaluronan. 
  • Extracellular superoxide dismutase is present in secretory vesicles of human neutrophils and released upon stimulation. 
  • Extracellular superoxide dismutase overexpression improves behavioral outcome from closed head injury in the mouse. 
  • Extracellular superoxide dismutase overexpression protects against aging-induced cognitive impairment in mice. 
  • Extracellular superoxide dismutase protects against matrix degradation of heparan sulfate in the lung. 
  • Extracellular superoxide dismutase protects lung development in hyperoxia-exposed newborn mice. 
  • Extracellular superoxide dismutase regulates cardiac function and fibrosis. 
  • Extracellular superoxide dismutase transgene overexpression preserves postischemic myocardial function in isolated murine hearts. 
  • Extracellular superoxide dismutase, nitric oxide, and central nervous system O2 toxicity. 
  • Extracellular-signal regulated kinase 1-dependent metabotropic glutamate receptor 5-induced long-term depression in the bed nucleus of the stria terminalis is disrupted by cocaine administration. 
  • Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. 
  • Extreme obesity due to impaired leptin signaling in mice does not cause knee osteoarthritis. 
  • Ezrin binding domain-deficient NHERF attenuates cAMP-mediated inhibition of Na(+)/H(+) exchange in OK cells. 
  • F-actin aggregates in transformed cells. 
  • FAT10: a novel mediator of Vpr-induced apoptosis in human immunodeficiency virus-associated nephropathy. 
  • FGF14 regulates presynaptic Ca2+ channels and synaptic transmission. 
  • FGF21-FGFR1 Coordinates Phospholipid Homeostasis, Lipid Droplet Function, and ER Stress in Obesity. 
  • FGF23 induces left ventricular hypertrophy. 
  • FGF23/FGFR4-mediated left ventricular hypertrophy is reversible. 
  • FGF9 promotes survival of germ cells in the fetal testis. 
  • FGFR4 blockade exerts distinct antitumorigenic effects in human embryonal versus alveolar rhabdomyosarcoma. 
  • FKBP12 is not required for the modulation of transforming growth factor beta receptor I signaling activity in embryonic fibroblasts and thymocytes. 
  • FKBP12 is the only FK506 binding protein mediating T-cell inhibition by the immunosuppressant FK506. 
  • FKBP51 inhibits GSK3β and augments the effects of distinct psychotropic medications. 
  • FMRP targets distinct mRNA sequence elements to regulate protein expression. 
  • FRA1 promotes squamous cell carcinoma growth and metastasis through distinct AKT and c-Jun dependent mechanisms. 
  • FRAP analysis reveals stabilization of adhesion structures in the epidermis compared to cultured keratinocytes. 
  • FTY720 stimulates multidrug transporter- and cysteinyl leukotriene-dependent T cell chemotaxis to lymph nodes. 
  • Facilitating haplotype analysis by fully automated analysis of all chromosomes in human-mouse hybrid cell lines. 
  • Facilitative glucose transporter Glut1 is actively excluded from rod outer segments. 
  • Factors influencing phenotypic diversity of human prostate carcinoma cells metastasizing in athymic nude mice. 
  • Facultative role of germinal centers and T cells in the somatic diversification of IgVH genes. 
  • Failure of 2-deoxy-D-glucose to stimulate feeding in deermice. 
  • Failure of adrenal corticosterone production in POMC-deficient mice results from lack of integrated effects of POMC peptides on multiple factors. 
  • Failure of red blood cell maturation in mice with defects in the high-density lipoprotein receptor SR-BI. 
  • Failure of spermatogenesis in mouse lines deficient in the Na(+)-K(+)-2Cl(-) cotransporter. 
  • Failure of terminal erythroid differentiation in EKLF-deficient mice is associated with cell cycle perturbation and reduced expression of E2F2. 
  • Failure of ventral body wall closure in mouse embryos lacking a procollagen C-proteinase encoded by Bmp1, a mammalian gene related to Drosophila tolloid. 
  • Faithful expression of GFP from the PLCbeta2 promoter in a functional class of taste receptor cells. 
  • Familial erythrocytosis associated with a short deletion in the erythropoietin receptor gene. 
  • Familial polycythemia due to truncations of the erythropoietin receptor. 
  • Far Upstream Element Binding Protein Plays a Crucial Role in Embryonic Development, Hematopoiesis, and Stabilizing Myc Expression Levels. 
  • Fas on renal parenchymal cells does not promote autoimmune nephritis in MRL mice. 
  • Fas preassociation required for apoptosis signaling and dominant inhibition by pathogenic mutations. 
  • Fas-activated serine/threonine phosphoprotein (FAST) is a regulator of alternative splicing. 
  • Fas/FasL play a central role in pancreatitis-induced hepatocyte apoptosis. 
  • Fasciated nerve-muscle explants for in vitro comparison of magnetic and electrical neuromuscular stimulation. 
  • Fasnall, a Selective FASN Inhibitor, Shows Potent Anti-tumor Activity in the MMTV-Neu Model of HER2(+) Breast Cancer. 
  • Fast acquisition and reconstruction of optical coherence tomography images via sparse representation. 
  • Fast skeletal muscle-specific expression of a quail troponin I gene in transgenic mice. 
  • Fast voice-coil scanning optical-resolution photoacoustic microscopy. 
  • Fasting prevents experimental murine colitis produced by dextran sulfate sodium and decreases interleukin-1 beta and insulin-like growth factor I messenger ribonucleic acid. 
  • Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. 
  • Fat hormones pull their weight in the CNS. 
  • Fat, carbohydrate, and calories in the development of diabetes and obesity in the C57BL/6J mouse. 
  • Fate Mapping In Vivo to Distinguish Bona Fide Microglia Versus Recruited Monocyte-Derived Macrophages in Retinal Disease. 
  • Fate mapping reveals that microglia and recruited monocyte-derived macrophages are definitively distinguishable by phenotype in the retina. 
  • Fate-mapping evidence that hepatic stellate cells are epithelial progenitors in adult mouse livers. 
  • Fatty acid elongase-5 (Elovl5) regulates hepatic triglyceride catabolism in obese C57BL/6J mice. 
  • Fatty acid homeostasis and induction of lipid regulatory genes in skeletal muscles of peroxisome proliferator-activated receptor (PPAR) alpha knock-out mice. Evidence for compensatory regulation by PPAR delta. 
  • Fatty acid synthesis is essential for survival of Cryptococcus neoformans and a potential fungicidal target. 
  • Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation. 
  • Fear and anxiety from principle to practice: implications for when to treat youth with anxiety disorders. 
  • Feasibility of whole-body functional mouse imaging using helical pinhole SPECT. 
  • Feedback in the brainstem: an excitatory disynaptic pathway for control of whisking. 
  • Female fertility is reduced in mice lacking Ca2+/calmodulin-dependent protein kinase IV. 
  • Female gender, estrogen loss, and Sub-RPE deposit formation in aged mice. 
  • Fenestrations of sarcoplasmic reticulum. Delineation by lanthanum acting as a fortuitous tracer and in situ negative stain. 
  • Fenretinide prevents lipid-induced insulin resistance by blocking ceramide biosynthesis. 
  • Ferritin heavy chain-mediated iron homeostasis and subsequent increased reactive oxygen species production are essential for epithelial-mesenchymal transition. 
  • Ferroxidase hephaestin's cell-autonomous role in the retinal pigment epithelium. 
  • Fetal alveolar epithelial cells contain [D-Ala(2)]-deltorphin I-like immunoreactivity: delta- and mu-opiate receptors mediate opposite effects in developing lung. 
  • Fetal brain subdivisions defined by R- and E-cadherin expressions: evidence for the role of cadherin activity in region-specific, cell-cell adhesion. 
  • Fetal hematopoietic stem cell transplantation into beta-thalassemic mice. 
  • Fgf8 is required for anterior heart field development. 
  • Fgf9 and Wnt4 act as antagonistic signals to regulate mammalian sex determination. 
  • Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination. 
  • Fiber type-specific nitric oxide protects oxidative myofibers against cachectic stimuli. 
  • Fiber-optic detector for real time dosimetry of a micro-planar x-ray beam. 
  • Fiber-optic stethoscope: a cardiac monitoring and gating system for magnetic resonance microscopy. 
  • Fibrinolysis in LPS-induced chronic airway disease. 
  • Fibroblast and hepatocyte behavior on synthetic polymer surfaces. 
  • Fibroblast growth factor 10 (FGF10) and branching morphogenesis in the embryonic mouse lung. 
  • Fibroblast growth factor 21 and thyroid hormone show mutual regulatory dependency but have independent actions in vivo. 
  • Fibroblast growth factor 21 mediates specific glucagon actions. 
  • Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease. 
  • Fibroblast growth factor 23 is not associated with and does not induce arterial calcification. 
  • Fibroblast growth factor homologous factor 13 regulates Na+ channels and conduction velocity in murine hearts. 
  • Fibroblast growth factor homologous factors in the heart: a potential locus for cardiac arrhythmias. 
  • Fibroblast growth factor homologous factors modulate cardiac calcium channels. 
  • Fibroblast growth factor receptor 2 regulates proliferation and Sertoli differentiation during male sex determination. 
  • Fibroblast growth factor receptor 4: the missing link between chronic kidney disease and FGF23-induced left ventricular hypertrophy? 
  • Fibroblast growth factor-23-mediated inhibition of renal phosphate transport in mice requires sodium-hydrogen exchanger regulatory factor-1 (NHERF-1) and synergizes with parathyroid hormone. 
  • Fibronectin and beta-catenin act in a regulatory loop in dermal fibroblasts to modulate cutaneous healing. 
  • Fibroproliferation in LPS-induced airway remodeling and bleomycin-induced fibrosis share common patterns of gene expression. 
  • Fibulin-2 is a driver of malignant progression in lung adenocarcinoma. 
  • Fibulin-3 is a novel TGF-β pathway inhibitor in the breast cancer microenvironment. 
  • Filamentation by Escherichia coli subverts innate defenses during urinary tract infection. 
  • Finale: the last minutes of Smads. 
  • Fine mapping of a putative rd cDNA and its co-segregation with rd expression. 
  • Fine mapping, gene content, comparative sequencing, and expression analyses support Ctla4 and Nramp1 as candidates for Idd5.1 and Idd5.2 in the nonobese diabetic mouse. 
  • Fine time course expression analysis identifies cascades of activation and repression and maps a putative regulator of mammalian sex determination. 
  • First dose in neonates: are juvenile mice, adults and in vitro-in silico data predictive of neonatal pharmacokinetics of fluconazole. 
  • First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway. 
  • Fish oil feeding modulates leukotriene production in murine lupus nephritis. 
  • Fish oil slows prostate cancer xenograft growth relative to other dietary fats and is associated with decreased mitochondrial and insulin pathway gene expression. 
  • Flanking nuclear matrix attachment regions synergize with the T cell receptor delta enhancer to promote V(D)J recombination. 
  • Flavopiridol induces apoptosis in chronic lymphocytic leukemia cells via activation of caspase-3 without evidence of bcl-2 modulation or dependence on functional p53. 
  • Flow Cytometric Identification of Tumor-Infiltrating Lymphocytes from Glioblastoma. 
  • Flow Cytometry for the Immunotoxicologist. 
  • Flow cytometric detection of lymphocyte proliferation in eyes with immunogenic inflammation. 
  • Flow cytometry sorting of recombinant mycobacterial species yields bacterial clones with enhanced insert expression. 
  • Flow velocity in the superficial lymphatic network of the mouse tail. 
  • Flt3 does not play a critical role in murine myeloid leukemias induced by MLL fusion genes. 
  • Flt3 is dispensable to the Hoxa9/Meis1 leukemogenic cooperation. 
  • Flunarizine enhancement of melphalan activity against drug-sensitive/resistant rhabdomyosarcoma. 
  • Fluorescence imaging of GABAA receptor-mediated intracellular [Cl-] in P19-N cells reveals unique pharmacological properties. 
  • Fluorescence linked enzyme chemoproteomic strategy for discovery of a potent and selective DAPK1 and ZIPK inhibitor. 
  • Fluorescence ratio imaging of interstitial pH in solid tumours: effect of glucose on spatial and temporal gradients. 
  • Fluorescence staining of the actin cytoskeleton in living cells with 7-nitrobenz-2-oxa-1,3-diazole-phallacidin. 
  • Fluorescence-based alternative splicing reporters for the study of epithelial plasticity in vivo. 
  • Fluorescence-based isolation of bacterial genes expressed within host cells. 
  • Fluorescent probes that stain living nerve terminals. 
  • Fluorine-18 Labeling of the HER2-Targeting Single-Domain Antibody 2Rs15d Using a Residualizing Label and Preclinical Evaluation. 
  • Fluorine-18 labeled chemotactic peptides: a potential approach for the PET imaging of bacterial infection. 
  • Fluorine-18 labeling of an anti-HER2 VHH using a residualizing prosthetic group via a strain-promoted click reaction: Chemistry and preliminary evaluation. 
  • Fluorine-18 labeling of monoclonal antibodies and fragments with preservation of immunoreactivity. 
  • Fluorine-18-labeled [Nle4,D-Phe7]-alpha-MSH, an alpha-melanocyte stimulating hormone analogue. 
  • Fluorine-18-labeled monoclonal antibody fragments: a potential approach for combining radioimmunoscintigraphy and positron emission tomography. 
  • Fluoxetine Maintains a State of Heightened Responsiveness to Motor Training Early After Stroke in a Mouse Model. 
  • Fluoxetine treatment prevents the inflammatory response in a mouse model of posttraumatic stress disorder. 
  • Fluvastatin downregulates VEGF-A expression in TNF-α-induced retinal vessel tortuosity. 
  • Focal adhesion kinase mediates the interferon-gamma-inducible GTPase-induced phosphatidylinositol 3-kinase/Akt survival pathway and further initiates a positive feedback loop of NF-kappaB activation. 
  • Folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation. 
  • Folate-targeted nanoparticle delivery of chemo- and radiotherapeutics for the treatment of ovarian cancer peritoneal metastasis. 
  • Follistatin in chondrocytes: the link between TRPV4 channelopathies and skeletal malformations. 
  • Follistatin operates downstream of Wnt4 in mammalian ovary organogenesis. 
  • Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development. 
  • Food reward in the absence of taste receptor signaling. 
  • Force plate for measuring the ground reaction forces in small animal locomotion. 
  • Force-frequency effect is a powerful determinant of myocardial contractility in the mouse. 
  • Forced expression of AID facilitates the isolation of class switch variants from hybridoma cells. 
  • Formation of Rathke's pouch requires dual induction from the diencephalon. 
  • Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity. 
  • Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes. 
  • Formulations which increase the size of lipoplexes prevent serum-associated inhibition of transfection. 
  • Four-dimensional MR microscopy of the mouse heart using radial acquisition and liposomal gadolinium contrast agent. 
  • Four-dimensional MRI of renal function in the developing mouse. 
  • Four-dimensional analysis of vascularization during primary development of an organ, the gonad. 
  • Fox-2 mediates epithelial cell-specific fibroblast growth factor receptor 2 exon choice. 
  • FoxA2, Nkx2.2, and PDX-1 regulate islet beta-cell-specific mafA expression through conserved sequences located between base pairs -8118 and -7750 upstream from the transcription start site. 
  • FoxO-dependent regulation of diacylglycerol kinase α gene expression. 
  • FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes. 
  • Foxp1 Is Indispensable for Ductal Morphogenesis and Controls the Exit of Mammary Stem Cells from Quiescence. 
  • Foxp3 and Toll-like receptor signaling balance Treg cell anabolic metabolism for suppression. 
  • Fragile X mental retardation protein is a Zika virus restriction factor that is antagonized by subgenomic flaviviral RNA. 
  • From breast to the brain: unraveling the puzzle of metastasis organotropism. 
  • From embryo to ethics: a career in science and social responsibility. An interview with Anne McLarne [by Brigid Hogan]. 
  • From embryo to teratocarcinoma in tissue culture. 
  • From the yolk sac to the spleen: New roles for Notch in regulating hematopoiesis. 
  • Frontline Science: Multiple cathepsins promote inflammasome-independent, particle-induced cell death during NLRP3-dependent IL-1β activation. 
  • Fructose and glucose can regulate mammalian target of rapamycin complex 1 and lipogenic gene expression via distinct pathways. 
  • Fructose consumption as a risk factor for non-alcoholic fatty liver disease. 
  • Fucosylation Deficiency in Mice Leads to Colitis and Adenocarcinoma. 
  • Fulfilling Koch's postulates of autoimmunity: anti-NR2 antibodies in mice and men. 
  • Full Spectrum of LPS Activation in Alveolar Macrophages of Healthy Volunteers by Whole Transcriptomic Profiling. 
  • Full genetic rescue of adenosine deaminase-deficient mice through introduction of the human gene. 
  • Fully deleted adenovirus persistently expressing GAA accomplishes long-term skeletal muscle glycogen correction in tolerant and nontolerant GSD-II mice. 
  • Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ. 
  • Fumonisins disrupt sphingolipid metabolism, folate transport, and neural tube development in embryo culture and in vivo: a potential risk factor for human neural tube defects among populations consuming fumonisin-contaminated maize. 
  • Function and regulation of calmodulin in endocrine cells. 
  • Function in athymic nude mice of parathyroid heterografts from patients with primary hyperparathyroidism and secondary hyperparathyroidism. 
  • Function of nuclear factor kappaB in pancreatic cancer metastasis. 
  • Function of tau protein in adult newborn neurons. 
  • Functional Genomic Analyses of Mendelian and Sporadic Disease Identify Impaired eIF2α Signaling as a Generalizable Mechanism for Dystonia. 
  • Functional TRPV4 channels are expressed in mouse skeletal muscle and can modulate resting Ca2+ influx and muscle fatigue. 
  • Functional Transcriptomics in Diverse Intestinal Epithelial Cell Types Reveals Robust MicroRNA Sensitivity in Intestinal Stem Cells to Microbial Status. 
  • Functional alterations of macrophages in autoimmune MRL-lpr/lpr mice. 
  • Functional analysis of a mammalian odorant receptor subfamily. 
  • Functional analysis of myocardial performance in murine hearts overexpressing the human beta 2-adrenergic receptor. 
  • Functional analysis of novel SNPs and mutations in human and mouse genomes. 
  • Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. 
  • Functional analysis of the putative integrin recognition motif on adeno-associated virus 9. 
  • Functional analysis of two distinct bronchiolar progenitors during lung injury and repair. 
  • Functional and molecular adaptations in skeletal muscle of myoglobin-mutant mice. 
  • Functional and molecular characterization of human monoclonal antibody reactive with the immunodominant region of HIV type 1 glycoprotein 41. 
  • Functional and molecular effects of arginine butyrate and prednisone on muscle and heart in the mdx mouse model of Duchenne Muscular Dystrophy. 
  • Functional association of CD7 with phosphatidylinositol 3-kinase: interaction via a YEDM motif. 
  • Functional characteristics and survival requirements of memory CD4+ T lymphocytes in vivo. 
  • Functional comparison of RGS9 splice isoforms in a living cell. 
  • Functional complementation between FADD and RIP1 in embryos and lymphocytes. 
  • Functional consequences of altering myocardial adrenergic receptor signaling. 
  • Functional differences between human and bovine immunodeficiency virus Tat transcription factors. 
  • Functional diversity of notch family genes in fetal lung development. 
  • Functional epialleles at an endogenous human centromere. 
  • Functional evaluation of nonphagocytic NAD(P)H oxidases. 
  • Functional evolution of mammalian odorant receptors. 
  • Functional expression of Mammalian odorant receptors. 
  • Functional expression of the multidrug resistance-associated protein in the yeast Saccharomyces cerevisiae. 
  • Functional genetic screen of human diversity reveals that a methionine salvage enzyme regulates inflammatory cell death. 
  • Functional genomics of the beta-cell: short-chain 3-hydroxyacyl-coenzyme A dehydrogenase regulates insulin secretion independent of K+ currents. 
  • Functional hyperdopaminergia in dopamine transporter knock-out mice. 
  • Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. 
  • Functional interaction between trace amine-associated receptor 1 and dopamine D2 receptor. 
  • Functional maturation of hPSC-derived forebrain interneurons requires an extended timeline and mimics human neural development. 
  • Functional nanofiber scaffolds with different spacers modulate adhesion and expansion of cryopreserved umbilical cord blood hematopoietic stem/progenitor cells. 
  • Functional neuroimaging using ultrasonic blood-brain barrier disruption and manganese-enhanced MRI. 
  • Functional organization of the genome may shape the species boundary in the house mouse. 
  • Functional photoacoustic microscopy of diabetic vasculature. 
  • Functional photoacoustic microscopy of pH. 
  • Functional redundancy of the Nur77 and Nor-1 orphan steroid receptors in T-cell apoptosis. 
  • Functional replacement of the mouse E2A gene with a human HEB cDNA. 
  • Functional specialization of mouse higher visual cortical areas. 
  • Functional transient receptor potential vanilloid 1 and transient receptor potential vanilloid 4 channels along different segments of the renal vasculature. 
  • Functional variants in TBX2 are associated with a syndromic cardiovascular and skeletal developmental disorder. 
  • Functional, non-clonal IgMa-restricted B cell receptor interactions with the HIV-1 envelope gp41 membrane proximal external region. 
  • Functionally rodless mice: transgenic models for the investigation of cone function in retinal disease and therapy. 
  • Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB. 
  • Functions of MutLalpha, replication protein A (RPA), and HMGB1 in 5'-directed mismatch repair. 
  • Functions of skin-resident γδ T cells. 
  • Fungal homoserine kinase (thr1Delta) mutants are attenuated in virulence and die rapidly upon threonine starvation and serum incubation. 
  • Fungal pathogen reduces potential for malaria transmission. 
  • Furin proteolytically processes the heparin-binding region of extracellular superoxide dismutase. 
  • Further Advances in Optimizing (2-Phenylcyclopropyl)methylamines as Novel Serotonin 2C Agonists: Effects on Hyperlocomotion, Prepulse Inhibition, and Cognition Models. 
  • Further characterization of the curative antibodies in Trypanosoma musculi infection. 
  • Further characterization of the oncornavirus inactivating factor in normal mouse serum. 
  • Further characterization of the platinum-reactive component of the alpha 2-macroglobulin-receptor recognition site. 
  • Further studies of a macrophage chemotaxis inhibitor (MCI) produced by neoplasms: murine tumors free of lactic dehydrogenase virus produce MCI. 
  • Fusigenic viral liposome for gene therapy in cardiovascular diseases. 
  • Fusion of the termini of the murine cytomegalovirus genome after infection. 
  • Fusobacterium nucleatum induces premature and term stillbirths in pregnant mice: implication of oral bacteria in preterm birth. 
  • Future directions in idiopathic pulmonary fibrosis research. An NHLBI workshop report. 
  • Future of early detection of lung cancer: the role of mouse models. 
  • Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. 
  • G Protein Coupled Receptor Kinase 3 Regulates Breast Cancer Migration, Invasion, and Metastasis. 
  • G Protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. 
  • G protein G(alpha)o is essential for vomeronasal function and aggressive behavior in mice. 
  • G protein-coupled receptor 56 regulates mechanical overload-induced muscle hypertrophy. 
  • G protein-coupled receptor internalization signaling is required for cardioprotection in ischemic preconditioning. 
  • G protein-coupled receptor kinase 2 in multiple sclerosis and experimental autoimmune encephalomyelitis. 
  • G protein-coupled receptor kinase 2 promotes flaviviridae entry and replication. 
  • G protein-coupled receptor kinase 3 (GRK3) gene disruption leads to loss of odorant receptor desensitization. 
  • G protein-coupled receptor kinase 5 regulates airway responses induced by muscarinic receptor activation. 
  • G protein-coupled receptor kinase 6 controls chronicity and severity of dextran sodium sulphate-induced colitis in mice. 
  • G protein-coupled receptor kinase-3-deficient mice exhibit WHIM syndrome features and attenuated inflammatory responses. 
  • G protein-coupled receptor kinase-5 attenuates atherosclerosis by regulating receptor tyrosine kinases and 7-transmembrane receptors. 
  • G protein-coupled receptor kinase/beta-arrestin systems and drugs of abuse: psychostimulant and opiate studies in knockout mice. 
  • G protein-coupled receptor kinases: from molecules to diseases. 
  • G(s)alpha deficiency in adipose tissue leads to a lean phenotype with divergent effects on cold tolerance and diet-induced thermogenesis. 
  • G(s)alpha deficiency in skeletal muscle leads to reduced muscle mass, fiber-type switching, and glucose intolerance without insulin resistance or deficiency. 
  • G-protein receptor kinase 3 (GRK3) influences opioid analgesic tolerance but not opioid withdrawal. 
  • G-protein-coupled receptor function in heart failure. 
  • G-protein-coupled receptor genes as protooncogenes: constitutively activating mutation of the alpha 1B-adrenergic receptor enhances mitogenesis and tumorigenicity. 
  • G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons. 
  • GABA receptor-mediated chloride transport in a "cell-free" membrane preparation from brain. 
  • GABAB receptor-mediated effects in synaptosomes of lethargic (lh/lh) mice. 
  • GABAB-activated gK+ in thalamic neurons in the lethargic (lh/lh) mouse model of generalized absence seizures. 
  • GABAergic pathway from zona incerta to neocortex: clarification. 
  • GATA2 regulates body water homeostasis through maintaining aquaporin 2 expression in renal collecting ducts. 
  • GATA4 and the two sides of gene expression reprogramming. 
  • GATA4 transcription factor is required for ventral morphogenesis and heart tube formation. 
  • GATA6 levels modulate primitive endoderm cell fate choice and timing in the mouse blastocyst. 
  • GB virus type C envelope protein E2 elicits antibodies that react with a cellular antigen on HIV-1 particles and neutralize diverse HIV-1 isolates. 
  • GD3 expression by cultured human tumor cells of neuroectodermal origin. 
  • GENIS: gene expression of sodium iodide symporter for noninvasive imaging of gene therapy vectors and quantification of gene expression in vivo. 
  • GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. 
  • GFRα1 released by nerves enhances cancer cell perineural invasion through GDNF-RET signaling. 
  • GGTase-I deficiency reduces tumor formation and improves survival in mice with K-RAS-induced lung cancer. 
  • GIT1 regulates synaptic structural plasticity underlying learning. 
  • GLP-1 receptor activation indirectly reduces hepatic lipid accumulation but does not attenuate development of atherosclerosis in diabetic male ApoE(-/-) mice. 
  • GMab-1, a high-affinity anti-3'-isoLM1/3',6'-isoLD1 IgG monoclonal antibody, raised in lacto-series ganglioside-defective knockout mice. 
  • GNA13 expression promotes drug resistance and tumor-initiating phenotypes in squamous cell cancers. 
  • GNA13 loss in germinal center B cells leads to impaired apoptosis and promotes lymphoma in vivo. 
  • GPR171 is a hypothalamic G protein-coupled receptor for BigLEN, a neuropeptide involved in feeding. 
  • GPR54 is a target for suppression of metastasis in endometrial cancer. 
  • GQ-16, a novel peroxisome proliferator-activated receptor γ (PPARγ) ligand, promotes insulin sensitization without weight gain. 
  • GREAT improves functional interpretation of cis-regulatory regions. 
  • GRHL2 coordinates regeneration of a polarized mucociliary epithelium from basal stem cells. 
  • GRK5 deficiency accelerates {beta}-amyloid accumulation in Tg2576 mice via impaired cholinergic activity. 
  • GRK5 deficiency leads to early Alzheimer-like pathology and working memory impairment. 
  • GRK5 deficiency leads to reduced hippocampal acetylcholine level via impaired presynaptic M2/M4 autoreceptor desensitization. 
  • GRK6 deficiency is associated with enhanced CXCR4-mediated neutrophil chemotaxis in vitro and impaired responsiveness to G-CSF in vivo. 
  • GRP94 (gp96) and GRP94 N-terminal geldanamycin binding domain elicit tissue nonrestricted tumor suppression. 
  • GRP94-associated enzymatic activities. Resolution by chromatographic fractionation. 
  • GRP94/gp96 elicits ERK activation in murine macrophages. A role for endotoxin contamination in NF-kappa B activation and nitric oxide production. 
  • GSK2193874 treatment at heatstroke onset reduced cell apoptosis in heatstroke mice. 
  • GUCY2C Signaling Opposes the Acute Radiation-Induced GI Syndrome. 
  • GUCY2C opposes systemic genotoxic tumorigenesis by regulating AKT-dependent intestinal barrier integrity. 
  • Gabapentin receptor alpha2delta-1 is a neuronal thrombospondin receptor responsible for excitatory CNS synaptogenesis. 
  • Gabapentin reduces infarct volume but does not suppress peri-infarct depolarizations. 
  • Gadolinium-conjugated gold nanoshells for multimodal diagnostic imaging and photothermal cancer therapy. 
  • Gain of glucose-independent growth upon metastasis of breast cancer cells to the brain. 
  • Galbraith Award: simvastatin attenuates experimental cerebral vasospasm and ameliorates serum markers of neuronal and endothelial injury in patients after subarachnoid hemorrhage: a dose-response effect dependent on endothelial nitric oxide synthase. 
  • Galectin-1 drives lymphoma CD20 immunotherapy resistance: validation of a preclinical system to identify resistance mechanisms. 
  • Galectin-3 directs antimicrobial guanylate binding proteins to vacuoles furnished with bacterial secretion systems. 
  • Gallbladder glycoprotein secretion in mice with hemolytic anemia and pigment gallstones. 
  • Galphaq-dependent signaling cascades stimulate water-seeking behavior. 
  • Galphaz negatively regulates insulin secretion and glucose clearance. 
  • Gamma delta T cell help of B cells is induced by repeated parasitic infection, in the absence of other T cells. 
  • Gamma interferon-induced inhibition of Toxoplasma gondii in astrocytes is mediated by IGTP. 
  • Gamma-globin gene promoter elements required for interaction with globin enhancers. 
  • Gamma-irradiation reduces the allogenicity of donor corneas. 
  • Ganglioside mapping of a human medulloblastoma xenograft. 
  • Garlic accelerates red blood cell turnover and splenic erythropoietic gene expression in mice: evidence for erythropoietin-independent erythropoiesis. 
  • Gastrin-releasing peptide blockade as a broad-spectrum anti-inflammatory therapy for asthma. 
  • Gastroesophageal reflux-associated aspiration alters the immune response in asthma. 
  • Gbetagamma-dependent phosphoinositide 3-kinase activation in hearts with in vivo pressure overload hypertrophy. 
  • Gelatin-embedded cell-polymer constructs for histological cryosectioning. 
  • Gender and estrogen supplementation increases severity of experimental choroidal neovascularization. 
  • Gender differences in human immunodeficiency virus type 1-specific CD8 responses in the reproductive tract and colon following nasal peptide priming and modified vaccinia virus Ankara boosting. 
  • Gender influences the response to experimental silica-induced lung fibrosis in mice. 
  • Gender-specific patterns of left ventricular and myocyte remodeling following myocardial infarction in mice deficient in the angiotensin II type 1a receptor. 
  • Gene Expression Profile of Dendritic Cell-Tumor Cell Hybrids Determined by Microarrays and Its Implications for Cancer Immunotherapy. 
  • Gene Expression Profiling of Cutaneous Injured and Non-Injured Nociceptors in SNI Animal Model of Neuropathic Pain. 
  • Gene Therapy for Modulation of T-Cell-Mediated Immune Response Provoked by Corneal Transplantation. 
  • Gene and protein expression pilot profiling and biomarkers in an experimental mouse model of hypertensive glaucoma. 
  • Gene by sex interaction in the etiology of coronary heart disease and the preceding metabolic syndrome. 
  • Gene conversion in the absence of reciprocal recombination. 
  • Gene delivery through cell culture substrate adsorbed DNA complexes. 
  • Gene dosage-dependent embryonic development and proliferation defects in mice lacking the transcriptional integrator p300. 
  • Gene dose-dependent control of hematopoiesis and hematologic tumor suppression by CBP. 
  • Gene duplication and neo-functionalization in the evolutionary and functional divergence of the metazoan copper transporters Ctr1 and Ctr2. 
  • Gene duplications at the chemokine locus on mouse chromosome 4: multiple strain-specific haplotypes and the deletion of secondary lymphoid-organ chemokine and EBI-1 ligand chemokine genes in the plt mutation. 
  • Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex. 
  • Gene expression phenotypes of oncogenic signaling pathways. 
  • Gene expression phenotypic models that predict the activity of oncogenic pathways. 
  • Gene expression profiles linked to AT1 angiotensin receptors in the kidney. 
  • Gene expression profiles of RAW264.7 macrophages stimulated with preparations of LPS differing in isolation and purity. 
  • Gene expression profiling of familial and sporadic interstitial pneumonia. 
  • Gene expression profiling of mouse bladder inflammatory responses to LPS, substance P, and antigen-stimulation. 
  • Gene expression signatures of radiation response are specific, durable and accurate in mice and humans. 
  • Gene expression signatures that predict radiation exposure in mice and humans. 
  • Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans. 
  • Gene knockouts of c-src, transforming growth factor beta 1, and tenascin suggest superfluous, nonfunctional expression of proteins. 
  • Gene on short arm of human X chromosome complements murine tsA1S9 DNA synthesis mutation. 
  • Gene order on the short arm of human chromosome 11: regional assignment of the LDH A gene distal to catalase in two translocations. 
  • Gene silencing using RNA interference in embryonic stem cells. 
  • Gene targeting in mice reveals a requirement for angiotensin in the development and maintenance of kidney morphology and growth factor regulation. 
  • Gene targeting in physiological investigations: studies of the renin-angiotensin system. 
  • Gene targeting to the ROSA26 locus directed by engineered zinc finger nucleases. 
  • Gene targeting. Getting nearer the mark. 
  • Gene therapies that restore dystrophin expression for the treatment of Duchenne muscular dystrophy. 
  • Gene therapy for cystic fibrosis using E1-deleted adenovirus: a phase I trial in the nasal cavity. The University of North Carolina at Chapel Hill. 
  • Gene therapy in a xenograft model of cystic fibrosis lung corrects chloride transport more effectively than the sodium defect. 
  • Gene therapy in tissue-engineered blood vessels. 
  • Gene therapy of cystic fibrosis lung disease using E1 deleted adenoviruses: a phase I trial. 
  • Gene therapy rescues cilia defects and restores olfactory function in a mammalian ciliopathy model. 
  • Gene therapy to manipulate effector T cell trafficking to tumors for immunotherapy. 
  • Gene transfer to hemophilia A mice via oral delivery of FVIII-chitosan nanoparticles. 
  • Gene transfer to the thymus. A means of abrogating the immune response to recombinant adenovirus. 
  • Gene-dose dependent effects of methamphetamine on interval timing in dopamine-transporter knockout mice. 
  • Gene-targeting studies of the renin-angiotensin system: mechanisms of hypertension and cardiovascular disease. 
  • General olfactory sensitivity database (GOSdb): candidate genes and their genomic variations. 
  • Generalized epilepsies: emerging insights into cellular and genetic mechanisms. 
  • Generation and analysis of partially haploid cells with Cre-mediated chromosome deletion in the lymphoid system. 
  • Generation and characterization of Tmeff2 mutant mice. 
  • Generation and characterization of a complete null estrogen receptor alpha mouse using Cre/LoxP technology. 
  • Generation and characterization of a mouse/human chimeric antibody directed against extracellular matrix protein tenascin. 
  • Generation and characterization of anti-Adeno-associated virus serotype 8 (AAV8) and anti-AAV9 monoclonal antibodies. 
  • Generation and characterization of mice lacking gastrin-releasing peptide receptor. 
  • Generation and comparison of CRISPR-Cas9 and Cre-mediated genetically engineered mouse models of sarcoma. 
  • Generation of CAR T cells for adoptive therapy in the context of glioblastoma standard of care. 
  • Generation of CD8+ T-cell responses by a recombinant nonpathogenic Mycobacterium smegmatis vaccine vector expressing human immunodeficiency virus type 1 Env. 
  • Generation of Dhx9-deficient clones in T-cell development with a mitotic recombination technique. 
  • Generation of a Magoh conditional allele in mice. 
  • Generation of a Mouse Full-length Balancer with Versatile Cassette-shuttling Selection Strategy. 
  • Generation of a loxP flanked bmp4loxP-lacZ allele marked by conditional lacZ expression. 
  • Generation of a microglial developmental index in mice and in humans reveals a sex difference in maturation and immune reactivity. 
  • Generation of a polyclonal Fab phage display library to the protozoan parasite Cryptosporidium parvum. 
  • Generation of a polyclonal fab phage display library to the human breast carcinoma cell line BT-20. 
  • Generation of anti-idiotypic reagents in the EGFRvIII tumor-associated antigen system. 
  • Generation of bone marrow and fetal liver chimeric mice. 
  • Generation of dynorphin knockout mice. 
  • Generation of hydrogen peroxide and failure of antioxidative responses in pancreatic islets of male C57BL/6 mice are associated with diabetes induced by multiple low doses of streptozotocin. 
  • Generation of mucosal anti-human immunodeficiency virus type 1 T-cell responses by recombinant Mycobacterium smegmatis. 
  • Generation of neutralizing activity against human immunodeficiency virus type 1 in serum by antibody gene transfer. 
  • Generation of normal lymphocyte populations following transplantation of adenosine-deaminase-deficient fetal liver cells. 
  • Generation of orthotopic and heterotopic human pancreatic cancer xenografts in immunodeficient mice. 
  • Generation of primary tumor-specific cytotoxic T lymphocytes from autologous and human lymphocyte antigen class I-matched allogeneic peripheral blood lymphocytes by B7 gene-modified melanoma cells. 
  • Generation of primary tumors with Flp recombinase in FRT-flanked p53 mice. 
  • Generation of renewable mouse intestinal epithelial cell monolayers and organoids for functional analyses. 
  • Generation of reovirus core-like particles in cells infected with hybrid vaccinia viruses that express genome segments L1, L2, L3, and S2. 
  • Generation of tumor-specific T lymphocytes for the treatment of posttransplant lymphoma. 
  • Genes for apolipoprotein B and microsomal triglyceride transfer protein are expressed in the heart: evidence that the heart has the capacity to synthesize and secrete lipoproteins. 
  • Genes for the neuronal immunoglobulin domain cell adhesion molecules neurofascin and Nr-CAM map to mouse chromosomes 1 and 12 and homologous human chromosomes. 
  • Genes that modify the hemochromatosis phenotype in mice. 
  • Genesis of the monophasic action potential: role of interstitial resistance and boundary gradients. 
  • Genetic Abrogation of Adenosine A3 Receptor Prevents Uninephrectomy and High Salt-Induced Hypertension. 
  • Genetic Differences in the Immediate Transcriptome Response to Stress Predict Risk-Related Brain Function and Psychiatric Disorders. 
  • Genetic Drivers of Kidney Defects in the DiGeorge Syndrome. 
  • Genetic NMDA receptor deficiency disrupts acute and chronic effects of cocaine but not amphetamine. 
  • Genetic Variants on Chromosome 1q41 Influence Ocular Axial Length and High Myopia 
  • Genetic ablation in transgenic mice with an attenuated diphtheria toxin A gene. 
  • Genetic ablation of phosphatidylinositol transfer protein function in murine embryonic stem cells. 
  • Genetic ablation of the steroid receptor coactivator-ubiquitin ligase, E6-AP, results in tissue-selective steroid hormone resistance and defects in reproduction. 
  • Genetic alterations that inhibit in vivo pressure-overload hypertrophy prevent cardiac dysfunction despite increased wall stress. 
  • Genetic analysis of MRL-lpr mice: relationship of the Fas apoptosis gene to disease manifestations and renal disease-modifying loci. 
  • Genetic analysis of collagen Q: roles in acetylcholinesterase and butyrylcholinesterase assembly and in synaptic structure and function. 
  • Genetic analysis of intracranial tumors in a murine model of glioma demonstrate a shift in gene expression in response to host immunity. 
  • Genetic analysis of susceptibility to Chlamydia trachomatis in mouse. 
  • Genetic and Pharmacologic Inactivation of ANGPTL3 and Cardiovascular Disease. 
  • Genetic and cellular evidence of decreased inflammation associated with reduced incidence of posttraumatic arthritis in MRL/MpJ mice. 
  • Genetic and epigenetic inactivation of Kruppel-like factor 4 in medulloblastoma. 
  • Genetic and pharmacologic analyses of the role of Icmt in Ras membrane association and function. 
  • Genetic approaches to studying norepinephrine function: knockout of the mouse norepinephrine transporter gene. 
  • Genetic basis of murine antibacterial defense to streptococcal lung infection. 
  • Genetic basis of murine responses to hyperoxia-induced lung injury. 
  • Genetic control of blood pressure and the angiotensinogen locus. 
  • Genetic control of inflammatory arthritis and glomerulonephritis in congenic lpr mice and their F1 hybrids. 
  • Genetic control of inflammatory arthritis in congenic lpr mice. 
  • Genetic control of peripheral leukocyte response to endotoxin in mice. 
  • Genetic control of the immune response to nuclease. V. Genetic linkage and strain distribution of anti-nuclease idiotypes. 
  • Genetic control of the immune response to staphylococcal nuclease in mice. 
  • Genetic control of the immune response to staphylococcal nuclease. IX. Recombination between genes determining BALB/c antinuclease idiotypes and the heavy chain allotype locus. 
  • Genetic control of the immune response to staphylococcal nuclease. VII. Role of non-H2-linked genes in the control of the anti-nuclease antibody response. 
  • Genetic control of the immune response to staphylococcal nuclease. VIII. Mapping of genes for antibodies to different antigenic regions of nuclease. 
  • Genetic deficiency of Irgm1 (LRG-47) suppresses induction of experimental autoimmune encephalomyelitis by promoting apoptosis of activated CD4+ T cells. 
  • Genetic deletion of A2A adenosine receptors in the striatum selectively impairs habit formation. 
  • Genetic deletion of receptor for hyaluronan-mediated motility (Rhamm) attenuates the formation of aggressive fibromatosis (desmoid tumor). 
  • Genetic differences in oxidative stress and inflammatory responses to diet-induced obesity do not alter liver fibrosis in mice. 
  • Genetic dissection of rod and cone pathways in the dark-adapted mouse retina. 
  • Genetic dissection of the mouse CNS using magnetic resonance microscopy. 
  • Genetic dissection of the mouse brain using high-field magnetic resonance microscopy. 
  • Genetic elimination of α3(IV) collagen fails to rescue anti-collagen B cells. 
  • Genetic engineering of a suboptimal islet graft with A20 preserves beta cell mass and function. 
  • Genetic engineering of murine CD8+ and CD4+ T cells for preclinical adoptive immunotherapy studies. 
  • Genetic enhancement of cognition in a kindred with cone-rod dystrophy due to RIMS1 mutation. 
  • Genetic evidence that relative synaptic efficacy biases the outcome of synaptic competition. 
  • Genetic factors determine the contribution of leukotrienes to acute inflammatory responses. 
  • Genetic heterogeneity of Myc-induced mammary tumors reflecting diverse phenotypes including metastatic potential. 
  • Genetic immunization with LYVE-1 cDNA yields function-blocking antibodies against native protein. 
  • Genetic inactivation of ANGPTL4 improves glucose homeostasis and is associated with reduced risk of diabetes. 
  • Genetic induction of tumorigenesis in swine. 
  • Genetic interactions between Shox2 and Hox genes during the regional growth and development of the mouse limb. 
  • Genetic manipulation of the renin-angiotensin system. 
  • Genetic mapping of the beta-arrestin 1 and 2 genes on mouse chromosomes 7 and 11 respectively. 
  • Genetic modeling of Ras-induced human rhabdomyosarcoma. 
  • Genetic modeling of human rhabdomyosarcoma. 
  • Genetic models in pharmacology: present status and future. 
  • Genetic modification of mesenchymal stem cells overexpressing CCR1 increases cell viability, migration, engraftment, and capillary density in the injured myocardium. 
  • Genetic modifications of mouse proopiomelanocortin peptide processing. 
  • Genetic modifier loci affecting survival and cardiac function in murine dilated cardiomyopathy. 
  • Genetic modifiers and oligogenic inheritance. 
  • Genetic modifiers of the Kv beta2-null phenotype in mice. 
  • Genetic networks of liver metabolism revealed by integration of metabolic and transcriptional profiling. 
  • Genetic polymorphisms: a cornerstone of translational biobehavioral research. 
  • Genetic regulation of glucose phosphate isomerase in mouse oocytes. 
  • Genetic regulation of pristane-induced oil granuloma responses. 
  • Genetic susceptibility to benzene-induced toxicity: role of NADPH: quinone oxidoreductase-1. 
  • Genetic variation in Mon1a affects protein trafficking and modifies macrophage iron loading in mice. 
  • Genetic variation in SP-A2 leads to differential binding to Mycoplasma pneumoniae membranes and regulation of host responses. 
  • Genetic vulnerability to diet-induced obesity in the C57BL/6J mouse: physiological and molecular characteristics. 
  • Genetic, cellular, and functional evidence for Ca2+ inflow through Cav1.2 and Cav1.3 channels in murine spiral ganglion neurons. 
  • Genetically determined P2X7 receptor pore formation regulates variability in chronic pain sensitivity. 
  • Genetically engineered models have advantages over xenografts for preclinical studies. 
  • Genetics of Angelman syndrome. 
  • Genetics of childhood disorders: XXIV. ADHD, part 8: hyperdopaminergic mice as an animal model of ADHD. 
  • Genetics of parkin-linked disease. 
  • Genetics. Origin of species in overdrive. 
  • Genome Engineering of Stem Cells for Autonomously Regulated, Closed-Loop Delivery of Biologic Drugs. 
  • Genome accessibility is widely preserved and locally modulated during mitosis. 
  • Genome engineering: the next genomic revolution. 
  • Genome variation in Cryptococcus gattii, an emerging pathogen of immunocompetent hosts. 
  • Genome wide analyses reveal little evidence for adaptive evolution in many plant species. 
  • Genome-scale mutational signatures of aflatoxin in cells, mice, and human tumors. 
  • Genome-wide activity-dependent MeCP2 phosphorylation regulates nervous system development and function. 
  • Genome-wide analysis of miRNA signature in the APPswe/PS1ΔE9 mouse model of alzheimer's disease. 
  • Genome-wide architecture of reproductive isolation in a naturally occurring hybrid zone between Mus musculus musculus and M. m. domesticus. 
  • Genome-wide association study identifies ZFHX1B as a susceptibility locus for severe myopia. 
  • Genome-wide identification of autosomal genes with allelic imbalance of chromatin state. 
  • Genome-wide identification of calcium-response factor (CaRF) binding sites predicts a role in regulation of neuronal signaling pathways. 
  • Genome-wide identification of regulatory elements in Sertoli cells. 
  • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels. 
  • Genome-wide mutational signatures of aristolochic acid and its application as a screening tool. 
  • Genome-wide prediction of imprinted murine genes. 
  • Genomic FHIT analysis in RER+ and RER- adenocarcinomas of the pancreas. 
  • Genomic abnormalities of the murine model of Fabry disease after disease-related perturbation, a systems biology approach. 
  • Genomic acquisition of a capsular polysaccharide virulence cluster by non-pathogenic Burkholderia isolates. 
  • Genomic amplification and oncogenic properties of the KCNK9 potassium channel gene. 
  • Genomic analysis of the chromosome 15q11-q13 Prader-Willi syndrome region and characterization of transcripts for GOLGA8E and WHCD1L1 from the proximal breakpoint region. 
  • Genomic analysis reveals distinct mechanisms and functional classes of SOX10-regulated genes in melanocytes. 
  • Genomic deletion of GIT2 induces a premature age-related thymic dysfunction and systemic immune system disruption. 
  • Genomic dissection of conserved transcriptional regulation in intestinal epithelial cells. 
  • Genomic distribution of CHD7 on chromatin tracks H3K4 methylation patterns. 
  • Genomic locus modulating corneal thickness in the mouse identifies POU6F2 as a potential risk of developing glaucoma. 
  • Genomic organization and cloning of the human homologue of murine Sipa-1. 
  • Genomic organization of adrenergic and serotonin receptors in the mouse: linkage mapping of sequence-related genes provides a method for examining mammalian chromosome evolution. 
  • Genomic organization, expression, and localization of murine Ran-binding protein 2 (RanBP2) gene. 
  • Genomic size of CENP-A domain is proportional to total alpha satellite array size at human centromeres and expands in cancer cells. 
  • Genomic structure and chromosomal localization of the novel ETS factor, PE-2 (ERF). 
  • Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice. 
  • Geometric calibration for a dual tube/detector micro-CT system. 
  • Geometrical differences among homologous neurons in mammals. 
  • Germ cells are not required to establish the female pathway in mouse fetal gonads. 
  • Germinal Center Hypoxia Potentiates Immunoglobulin Class Switch Recombination. 
  • Germinal center formation, immunoglobulin class switching, and autoantibody production driven by "non alpha/beta" T cells. 
  • Germline Genetic IKZF1 Variation and Predisposition to Childhood Acute Lymphoblastic Leukemia. 
  • Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient. 
  • Germline sequences of V(H)7183 gene family members in C57BL/6 mice demonstrate natural selection of particular sequences during recent evolution. 
  • Germline transcription from T-cell receptor Vbeta gene is uncoupled from allelic exclusion. 
  • Gestational, pathologic and biochemical differences between very long-chain acyl-CoA dehydrogenase deficiency and long-chain acyl-CoA dehydrogenase deficiency in the mouse. 
  • Getting biological about the genetics of diabetes. 
  • Ghrelin enhances olfactory sensitivity and exploratory sniffing in rodents and humans. 
  • Giant ankyrin-G stabilizes somatodendritic GABAergic synapses through opposing endocytosis of GABAA receptors. 
  • Giant ankyrin-G: a critical innovation in vertebrate evolution of fast and integrated neuronal signaling. 
  • Gipr is essential for adrenocortical steroidogenesis; however, corticosterone deficiency does not mediate the favorable metabolic phenotype of Gipr(-/-) mice. 
  • Gli Transcription Factors Mediate the Oncogenic Transformation of Prostate Basal Cells Induced by a Kras-Androgen Receptor Axis. 
  • Gli activity correlates with tumor grade in platelet-derived growth factor-induced gliomas. 
  • Gli2 and p53 cooperate to regulate IGFBP-3- mediated chondrocyte apoptosis in the progression from benign to malignant cartilage tumors. 
  • Glial ankyrins facilitate paranodal axoglial junction assembly. 
  • Glial cell line-derived neurotrophic factor administration in postnatal life results in motor unit enlargement and continuous synaptic remodeling at the neuromuscular junction. 
  • Glial localization of antiquitin: implications for pyridoxine-dependent epilepsy. 
  • Glioblastoma stem cells generate vascular pericytes to support vessel function and tumor growth. 
  • Glioblastoma stem-like cells give rise to tumour endothelium. 
  • Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. 
  • Glioma stem cells promote radioresistance by preferential activation of the DNA damage response. 
  • Glipizide stimulates sympathetic outflow in diabetes-prone mice. 
  • Global Identification of EVI1 Target Genes in Acute Myeloid Leukemia. 
  • Global analysis of microRNA target gene expression reveals that miRNA targets are lower expressed in mature mouse and Drosophila tissues than in the embryos. 
  • Global gene expression profiling reveals similarities and differences among mouse pluripotent stem cells of different origins and strains. 
  • Glomerular type 1 angiotensin receptors augment kidney injury and inflammation in murine autoimmune nephritis. 
  • Glucagon-like peptide-1 receptor agonists increase pancreatic mass by induction of protein synthesis. 
  • Glucocorticoid-treated mice are an inappropriate positive control for long-term preclinical studies in the mdx mouse. 
  • Glucocorticoids and histone deacetylase inhibitors cooperate to block the invasiveness of basal-like breast cancer cells through novel mechanisms. 
  • Glucose Metabolism in Cancer: The Saga of Pyruvate Kinase Continues. 
  • Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter. 
  • Glucose metabolism attenuates p53 and Puma-dependent cell death upon growth factor deprivation. 
  • Glucose uptake is limiting in T cell activation and requires CD28-mediated Akt-dependent and independent pathways. 
  • Glucose-6-phosphatase mutation G188R confers an atypical glycogen storage disease type 1b phenotype. 
  • Glucose-regulated protein 94/glycoprotein 96 elicits bystander activation of CD4+ T cell Th1 cytokine production in vivo. 
  • Glutamate acting at NMDA receptors stimulates embryonic cortical neuronal migration. 
  • Glutamate decarboxylase isoforms in thalamic nuclei in lethargic mouse model of absence seizures. 
  • Glutamate receptors as targets of protein kinase C in the pathophysiology and treatment of animal models of mania. 
  • Glutamatergic modulation of hyperactivity in mice lacking the dopamine transporter. 
  • Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies. 
  • Glutamine attenuates inflammation and NF-kappaB activation via Cullin-1 deneddylation. 
  • Glutamine attenuation of cell death and inducible nitric oxide synthase expression following inflammatory cytokine-induced injury is dependent on heat shock factor-1 expression. 
  • Glutamine enhances heat shock protein 70 expression via increased hexosamine biosynthetic pathway activity. 
  • Glutamine in acute lung injury: the experimental model matters. 
  • Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1. 
  • Glutamine therapy improves outcome of in vitro and in vivo experimental colitis models. 
  • Glutamine's protection against cellular injury is dependent on heat shock factor-1. 
  • Glutamine's protection against sepsis and lung injury is dependent on heat shock protein 70 expression. 
  • Glutamine-mediated attenuation of cellular metabolic dysfunction and cell death after injury is dependent on heat shock factor-1 expression. 
  • Glutamine-mediated dual regulation of heat shock transcription factor-1 activation and expression. 
  • Glutathione and glutathione S-transferase in benign and malignant prostate cell lines and prostate tissues. 
  • Glutathione depletion or radiation treatment alters respiration and induces apoptosis in R3230Ac mammary carcinoma. 
  • Glutathione peroxidase-deficient smooth muscle cells cause paracrine activation of normal smooth muscle cells via cyclophilin A. 
  • Glutathione protects cardiac and skeletal muscle from cyclophosphamide-induced toxicity. 
  • Glutathione-associated cis-diamminedichloroplatinum(II) metabolism and ATP-dependent efflux from leukemia cells. Molecular characterization of glutathione-platinum complex and its biological significance. 
  • Glutathione-mediated preservation and enhancement of isolated perifused islet function. 
  • Glycan binding avidity determines the systemic fate of adeno-associated virus type 9. 
  • Glycated AAV vectors: chemical redirection of viral tissue tropism. 
  • Glyceraldehyde 3-phosphate dehydrogenase is an enzyme-crystallin in diurnal geckos of the genus Phelsuma. 
  • Glycerol-3-phosphate acyltransferase (GPAT)-1, but not GPAT4, incorporates newly synthesized fatty acids into triacylglycerol and diminishes fatty acid oxidation. 
  • Glycine receptor beta-subunit gene mutation in spastic mouse associated with LINE-1 element insertion. 
  • Glycogen storage in multiple muscles of old GSD-II mice can be rapidly cleared after a single intravenous injection with a modified adenoviral vector expressing hGAA. 
  • Glycogen synthase kinase 3alpha and 3beta mediate a glucose-sensitive antiapoptotic signaling pathway to stabilize Mcl-1. 
  • Glycogen synthase: a putative locus for diet-induced hyperglycemia. 
  • Glycogen-branching enzyme deficiency leads to abnormal cardiac development: novel insights into glycogen storage disease IV. 
  • Glycolipids and glycosyltransferases in permanent cell lines established from human medulloblastomas. 
  • Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production. 
  • Glycoprotein 96 perpetuates the persistent inflammation of rheumatoid arthritis. 
  • Glymphatic fluid transport controls paravascular clearance of AAV vectors from the brain. 
  • Gnao1 (G alphaO protein) is a likely genetic contributor to variation in physical dependence on opioids in mice. 
  • Gnotobiotic models for study of the microbial ecology of Clostridium difficile and Escherichia coli. 
  • Gold nanoparticles provide bright long-lasting vascular contrast for CT imaging. 
  • Gold nanostars: surfactant-free synthesis, 3D modelling, and two-photon photoluminescence imaging. 
  • Gonadectomy prevents the increase in blood pressure and glomerular injury in angiotensin-converting enzyme 2 knockout diabetic male mice. Effects on renin-angiotensin system. 
  • Gonadotropin-releasing hormone neuronal cell lines. 
  • Gp91phox contributes to NADPH oxidase activity in aortic fibroblasts but not smooth muscle cells. 
  • Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. 
  • Gpr126/Adgrg6 deletion in cartilage models idiopathic scoliosis and pectus excavatum in mice. 
  • Gq signaling causes glomerular injury by activating TRPC6. 
  • Gq-dependent signaling upregulates COX2 in glomerular podocytes. 
  • Gradated assembly of multiple proteins into supramolecular nanomaterials. 
  • Gradients of transgene expression directed by the human myoglobin promoter in the developing mouse heart. 
  • Graft hyporeactivity induced by donor-derived dendritic cell progenitors. 
  • Graft hyporeactivity induced by immature donor-derived dendritic cells. 
  • Graft versus host disease following allogeneic bone marrow transplantation. 
  • Graft-extrinsic cells predominate in vein graft arterialization. 
  • Graft-induced restoration of function in hereditary cerebellar ataxia. 
  • Graft-versus-host disease prevention by rapamycin: cellular mechanisms. 
  • Graft-versus-host disease: the viewpoint from the donor T cell. 
  • Grafted cerebellar cells in a mouse model of hereditary ataxia express IGF-I system genes and partially restore behavioral function. 
  • Granulocyte chemotaxis and disease expression are differentially regulated by GRK subtype in an acute inflammatory arthritis model (K/BxN). 
  • Granulysin is a key mediator for disseminated keratinocyte death in Stevens-Johnson syndrome and toxic epidermal necrolysis. 
  • Granzyme B is dispensable for immunologic tolerance to self in a murine model of systemic lupus erythematosus. 
  • Grk5l controls heart development by limiting mTOR signaling during symmetry breaking. 
  • Growth Arrest Specific 8 (Gas8) and G protein-coupled receptor kinase 2 (GRK2) cooperate in the control of Smoothened signaling. 
  • Growth and chemotherapeutic response in athymic mice of tumors arising from human glioma-derived cell lines. 
  • Growth factor erv1-like modulates Drp1 to preserve mitochondrial dynamics and function in mouse embryonic stem cells. 
  • Growth factor modulation of p53-mediated growth arrest versus apoptosis. 
  • Growth factor receptor-bound protein 14 undergoes light-dependent intracellular translocation in rod photoreceptors: functional role in retinal insulin receptor activation. 
  • Growth factor receptors as molecular targets for cancer diagnosis and therapy. 
  • Growth factors can influence cell growth and survival through effects on glucose metabolism. 
  • Growth factors regulate beta-catenin-mediated TCF-dependent transcriptional activation in fibroblasts during the proliferative phase of wound healing. 
  • Growth failure and AIDS-like cachexia syndrome in HIV-1 transgenic mice. 
  • Growth hormone accelerates immune recovery following allogeneic T-cell-depleted bone marrow transplantation in mice. 
  • Growth hormone and prolactin receptors in adipogenesis: STAT-5 activation, suppressors of cytokine signaling, and regulation of insulin-like growth factor I. 
  • Growth hormone mitigates against lethal irradiation and enhances hematologic and immune recovery in mice and nonhuman primates. 
  • Growth hormone regulates phosphorylation and function of CCAAT/enhancer-binding protein beta by modulating Akt and glycogen synthase kinase-3. 
  • Growth inhibition of a human lung adenocarcinoma cell line by genetic complementation with chromosome 11. 
  • Growth inhibition of pathogenic bacteria by sulfonylurea herbicides. 
  • Growth of triple-negative breast cancer cells relies upon coordinate autocrine expression of the proinflammatory cytokines IL-6 and IL-8. 
  • Growth phenotypes and biosafety profiles in poliovirus-receptor transgenic mice of recombinant oncolytic polio/human rhinoviruses. 
  • Growth signaling at the nexus of stem cell life and death. 
  • Growth, morphology, and serial transplantation of anaplastic human gliomas in athymic mice. 
  • Guanine analogues enhance antisense oligonucleotide-induced exon skipping in dystrophin gene in vitro and in vivo. 
  • Guanine arabinoside as a bone marrow-purging agent. 
  • Guanine repeat-containing sequences confer transcription-dependent instability in an orientation-specific manner in yeast. 
  • Guanylate Binding Proteins Regulate Inflammasome Activation in Response to Hyperinjected Yersinia Translocon Components. 
  • Guanylate binding proteins enable rapid activation of canonical and noncanonical inflammasomes in Chlamydia-infected macrophages. 
  • Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. 
  • Guanylyl cyclase C suppresses intestinal tumorigenesis by restricting proliferation and maintaining genomic integrity. 
  • Guanylyl cyclase-D in the olfactory CO2 neurons is activated by bicarbonate. 
  • Guidelines for the welfare and use of animals in cancer research. 
  • Guinea pig and bovine zeta-crystallins have distinct functional characteristics highlighting replacements in otherwise similar structures. 
  • Gustatory effects of capsaicin that are independent of TRPV1 receptors. 
  • Gut bacteria that prevent growth impairments transmitted by microbiota from malnourished children. 
  • Gut barrier dysfunction in the Apc(Min/+) mouse model of colon cancer cachexia. 
  • Gut immune maturation depends on colonization with a host-specific microbiota. 
  • Gut microbiota from twins discordant for obesity modulate metabolism in mice. 
  • Gαi is required for carvedilol-induced β1 adrenergic receptor β-arrestin biased signaling. 
  • Gαi/o-coupled receptor signaling restricts pancreatic β-cell expansion. 
  • Gαz regulates BDNF-induction of axon growth in cortical neurons. 
  • H(2)O(2)-induced O(2) production by a non-phagocytic NAD(P)H oxidase causes oxidant injury. 
  • H-2K molecules have two different C-termini, one of which is K-region specific. 
  • H-2K-, H-21- and H-2D-restricted hybridoma contact sensitivity effector cells. 
  • H1 RNA polymerase III promoter-driven expression of an RNA aptamer leads to high-level inhibition of intracellular protein activity. 
  • H1 histone and nucleosome repeat length alterations associated with the in vitro differentiation of murine embryonal carcinoma cells to extra-embryonic endoderm. 
  • H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection. 
  • HASF (C3orf58) is a novel ligand of the insulin-like growth factor 1 receptor. 
  • HASF is a stem cell paracrine factor that activates PKC epsilon mediated cytoprotection. 
  • HDAC3 sets the timer on muscle fuel switching. 
  • HDAC4 promotes Pax7-dependent satellite cell activation and muscle regeneration. 
  • HDAC4 regulates muscle fiber type-specific gene expression programs. 
  • HDAC6 controls autophagosome maturation essential for ubiquitin-selective quality-control autophagy. 
  • HDAC6 controls major cell response pathways to cytotoxic accumulation of protein aggregates. 
  • HDAC6 is a microtubule-associated deacetylase. 
  • HDAC6 maintains mitochondrial connectivity under hypoxic stress by suppressing MARCH5/MITOL dependent MFN2 degradation. 
  • HDAC6 modulates cell motility by altering the acetylation level of cortactin. 
  • HDAC6 regulates Hsp90 acetylation and chaperone-dependent activation of glucocorticoid receptor. 
  • HDAC6 regulates the dynamics of lytic granules in cytotoxic T lymphocytes. 
  • HDMX regulates p53 activity and confers chemoresistance to 3-bis(2-chloroethyl)-1-nitrosourea. 
  • HEPSIN inhibits cell growth/invasion in prostate cancer cells. 
  • HER2 overexpression elicits a proinflammatory IL-6 autocrine signaling loop that is critical for tumorigenesis. 
  • HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development. 
  • HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism. 
  • HIF1α and HIF2α exert distinct nutrient preferences in renal cells. 
  • HIV infection and the dynamic interplay between the thymus and the peripheral T cell pool. 
  • HIV type 1 V3 region primer-induced antibody suppression is overcome by administration of C4-V3 peptides as a polyvalent immunogen. 
  • HIV vaccines. Magic of the occult? 
  • HIV-1 Envelope Mimicry of Host Enzyme Kynureninase Does Not Disrupt Tryptophan Metabolism. 
  • HIV-1 Nef induces dedifferentiation of podocytes in vivo: a characteristic feature of HIVAN. 
  • HIV-1 Nef induces proliferation and anchorage-independent growth in podocytes. 
  • HIV-1 Vpr activates the DNA damage response in renal tubule epithelial cells. 
  • HIV-1 Vpr inhibits cytokinesis in human proximal tubule cells. 
  • HIV-1 antibodies and vaccine antigen selectively interact with lipid domains. 
  • HIV-1 gp140 epitope recognition is influenced by immunoglobulin DH gene segment sequence. 
  • HIV-1 induces renal epithelial dedifferentiation in a transgenic model of HIV-associated nephropathy. 
  • HIV-1 infection initiates an inflammatory cascade in human renal tubular epithelial cells. 
  • HIV-1 infection: fooling the gatekeeper. 
  • HIV-1 neutralizing monoclonal antibodies induced by a synthetic peptide. 
  • HIV-1-induced cell fusion is mediated by multiple regions within both the viral envelope and the CCR-5 co-receptor. 
  • HIV-associated nephropathy. 
  • HLA-B-associated transcript 3 (Bat3)/Scythe is essential for p300-mediated acetylation of p53. 
  • HMG-CoA reductase inhibitors (statins) characterized as direct inhibitors of P-glycoprotein. 
  • HMGB1-RAGE pathway drives peroxynitrite signaling-induced IBD-like inflammation in murine nonalcoholic fatty liver disease. 
  • HNF-3 beta as a regulator of floor plate development. 
  • HPV16 E6 confers p53-dependent and p53-independent phenotypes in the epidermis of mice deficient for E6AP. 
  • HSV-1 retinitis and delayed hypersensitivity in DBA/2 and C57BL/6 mice. 
  • Haem oxygenase-1 prevents cell death by regulating cellular iron. 
  • Haemophilus influenzae stimulates ICAM-1 expression on respiratory epithelial cells. 
  • Hand-held spectroscopic device for in vivo and intraoperative tumor detection: contrast enhancement, detection sensitivity, and tissue penetration. 
  • Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration. 
  • Handheld optical-resolution photoacoustic microscopy. 
  • Handling and environmental enrichment do not rescue learning and memory impairments in alphaCamKII(T286A) mutant mice. 
  • Haploinsufficiency for Core Exon Junction Complex Components Disrupts Embryonic Neurogenesis and Causes p53-Mediated Microcephaly. 
  • Haploinsufficiency in peptidylglycine alpha-amidating monooxygenase leads to altered synaptic transmission in the amygdala and impaired emotional responses. 
  • Haploinsufficiency of RanBP2 is neuroprotective against light-elicited and age-dependent degeneration of photoreceptor neurons. 
  • Haploinsufficiency of the transcription factors FOXC1 and FOXC2 results in aberrant ocular development. 
  • Haploinsufficient Bmp4 ocular phenotypes include anterior segment dysgenesis with elevated intraocular pressure. 
  • Haploinsufficient phenotypes in Bmp4 heterozygous null mice and modification by mutations in Gli3 and Alx4. 
  • Hapten addition to an MHC class I-binding peptide causes substantial adjustments of the TCR structure of the responding CD8(+) T cells. 
  • Hapten-specific T cell response to 4-hydroxy-3-nitrophenyl acetyl. X. Characterization of distinct T cell subsets mediating cutaneous sensitivity responses. 
  • Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. 
  • Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VI. Evidence for different T cell receptors in cells that mediate H-21-restricted and H-2D-restricted cutaneous sensitivity responses. 
  • Hapten-specific T cell responses to 4-hydroxy-3-nitrophenyl acetyl. VIII. Suppressor cell pathways in cutaneous sensitivity responses. 
  • Haptoglobin modifies the hemochromatosis phenotype in mice. 
  • Harboring of particulate allergens within secretory compartments by mast cells following IgE/FcepsilonRI-lipid raft-mediated phagocytosis. 
  • Harnessing Hsp90 function as a powerful, broadly effective therapeutic strategy for fungal infectious disease. 
  • Harnessing the power of cell-penetrating peptides: activatable carriers for targeting systemic delivery of cancer therapeutics and imaging agents. 
  • Have gene knockouts caused evolutionary reversals in the mammalian first arch? 
  • Heart and lung disease in engineered mice. 
  • Heart size-independent analysis of myocardial function in murine pressure overload hypertrophy. 
  • Heat shock protein 70-binding protein 1 is highly expressed in high-grade gliomas, interacts with multiple heat shock protein 70 family members, and specifically binds brain tumor cell surfaces. 
  • Heat shock protein 90 suppresses tumor necrosis factor alpha induced apoptosis by preventing the cleavage of Bid in NIH3T3 fibroblasts. 
  • Heat shock proteins HSP27 and HSP70 are present in the skin and are important mediators of allergic contact hypersensitivity. 
  • Heat-induced gene expression as a novel targeted cancer gene therapy strategy. 
  • Heating or freezing bone. Effects on angiogenesis induction and growth potential in mice. 
  • Hedgehog and Notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas. 
  • Hedgehog controls hepatic stellate cell fate by regulating metabolism. 
  • Hedgehog inhibits β-catenin activity in synovial joint development and osteoarthritis. 
  • Hedgehog pathway activation and epithelial-to-mesenchymal transitions during myofibroblastic transformation of rat hepatic cells in culture and cirrhosis. 
  • Hedgehog pathway inhibition in chondrosarcoma using the smoothened inhibitor IPI-926 directly inhibits sarcoma cell growth. 
  • Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer. 
  • Hedgehog signaling blockade delays hepatocarcinogenesis induced by hepatitis B virus X protein. 
  • Hedgehog signaling is critical for normal liver regeneration after partial hepatectomy in mice. 
  • Hedgehog signaling maintains resident hepatic progenitors throughout life. 
  • Hedgehog signaling regulates epithelial-mesenchymal transition during biliary fibrosis in rodents and humans. 
  • Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. 
  • Hedgehog signalling regulates liver sinusoidal endothelial cell capillarisation. 
  • Hedgehog-GLI signaling inhibition suppresses tumor growth in squamous lung cancer. 
  • Hedgehog-mediated epithelial-to-mesenchymal transition and fibrogenic repair in nonalcoholic fatty liver disease. 
  • Hedgehog-mediated mesenchymal-epithelial interactions modulate hepatic response to bile duct ligation. 
  • Hel-N1, an RNA-binding protein, is a ligand for an A + U rich region of the GLUT1 3' UTR. 
  • Helicobacter infection decreases reproductive performance of IL10-deficient mice. 
  • Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice. 
  • Helicobacter typhlonius and Helicobacter rodentium differentially affect the severity of colon inflammation and inflammation-associated neoplasia in IL10-deficient mice. 
  • Helix-loop-helix transcription factors E12 and E47 are not essential for skeletal or cardiac myogenesis, erythropoiesis, chondrogenesis, or neurogenesis. 
  • Helper T cell subsets for immunoglobulin A responses: oral immunization with tetanus toxoid and cholera toxin as adjuvant selectively induces Th2 cells in mucosa associated tissues. 
  • Helper Th1 and Th2 cell responses following mucosal or systemic immunization with cholera toxin. 
  • Hemagglutinin stalk-based universal vaccine constructs protect against group 2 influenza A viruses. 
  • Hematopoietic stem cell dose correlates with the speed of immune reconstitution after stem cell transplantation. 
  • Hematopoietic stem cells convert into liver cells within days without fusion. 
  • Hematopoietic-specific Stat5-null mice display microcytic hypochromic anemia associated with reduced transferrin receptor gene expression. 
  • Heme Oxygenase-1/Carbon Monoxide System and Embryonic Stem Cell Differentiation and Maturation into Cardiomyocytes. 
  • Heme induces programmed necrosis on macrophages through autocrine TNF and ROS production. 
  • Heme oxygenase 1 is required for mammalian iron reutilization. 
  • Heme oxygenase-1 couples activation of mitochondrial biogenesis to anti-inflammatory cytokine expression. 
  • Heme oxygenase-1 gene ablation or expression modulates cisplatin-induced renal tubular apoptosis. 
  • Heme oxygenase-1 regulates cardiac mitochondrial biogenesis via Nrf2-mediated transcriptional control of nuclear respiratory factor-1. 
  • Heme-oxygenase-1-induced protection against hypoxia/reoxygenation is dependent on biliverdin reductase and its interaction with PI3K/Akt pathway. 
  • Hemodynamic Characterization of Rodent Models of Pulmonary Arterial Hypertension. 
  • Hemodynamic effects of metalloporphyrin catalytic antioxidants: structure-activity relationships and species specificity. 
  • Hemodynamic effects of vasorelaxant compounds in mice lacking one, two or all three angiotensin II receptors. 
  • Hemoglobin S-nitrosylation plays an essential role in cardioprotection. 
  • Hemoglobin conformation couples erythrocyte S-nitrosothiol content to O2 gradients. 
  • Hemoglobin induction in mouse macrophages. 
  • Hemoglobin βCys93 is essential for cardiovascular function and integrated response to hypoxia. 
  • Hemorrhage and thrombus formation in early experimental osteonecrosis. 
  • Heparan sulfate is a plasma biomarker of acute cellular allograft rejection. 
  • Heparan sulfate mimetic PG545-mediated antilymphoma effects require TLR9-dependent NK cell activation. 
  • Heparan sulfate, an endogenous TLR4 agonist, promotes acute GVHD after allogeneic stem cell transplantation. 
  • Heparin binding EGF is necessary for vasospastic response to endothelin. 
  • Heparin cofactor II in atherosclerotic lesions from the Pathobiological Determinants of Atherosclerosis in Youth (PDAY) study. 
  • Heparin modifies the immunogenicity of positively charged proteins. 
  • Heparin-induced thrombocytopenia/thrombosis in a transgenic mouse model requires human platelet factor 4 and platelet activation through FcgammaRIIA. 
  • Heparin-induced thrombocytopenia: an autoimmune disorder regulated through dynamic autoantigen assembly/disassembly. 
  • Hepatic FTO expression is increased in NASH and its silencing attenuates palmitic acid-induced lipotoxicity. 
  • Hepatic SRC-1 activity orchestrates transcriptional circuitries of amino acid pathways with potential relevance for human metabolic pathogenesis. 
  • Hepatic accumulation of Hedgehog-reactive progenitors increases with severity of fatty liver damage in mice. 
  • Hepatic angiomyolipoma and hepatic stellate cells share a similar gene expression profile. 
  • Hepatic fibrogenesis requires sympathetic neurotransmitters. 
  • Hepatic fibrosis associated with aging in four stocks of mice. 
  • Hepatic hyperplasia in noncirrhotic fatty livers: is obesity-related hepatic steatosis a premalignant condition? 
  • Hepatic insulin signaling is required for obesity-dependent expression of SREBP-1c mRNA but not for feeding-dependent expression. 
  • Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa). 
  • Hepatic receptor that specifically binds oligosaccharides containing fucosyl alpha1 leads to 3 N-acetylglucosamine linkages. 
  • Hepatic stellate cells undermine the allostimulatory function of liver myeloid dendritic cells via STAT3-dependent induction of IDO. 
  • Hepatic β-arrestin 2 is essential for maintaining euglycemia. 
  • Hepatocyte-targeted HFE and TFR2 control hepcidin expression in mice. 
  • Hepatorenal correction in murine glycogen storage disease type I with a double-stranded adeno-associated virus vector. 
  • Hepcidin antimicrobial peptide transgenic mice exhibit features of the anemia of inflammation. 
  • Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice. 
  • Hepcidin induction by transgenic overexpression of Hfe does not require the Hfe cytoplasmic tail, but does require hemojuvelin. 
  • Hepcidin, a candidate modifier of the hemochromatosis phenotype in mice. 
  • Her2/neu signaling blockade improves tumor oxygenation in a multifactorial fashion in Her2/neu+ tumors. 
  • Hereditary angioedema: a half century of progress. 
  • Hereditary hemochromatosis protein, HFE, interaction with transferrin receptor 2 suggests a molecular mechanism for mammalian iron sensing. 
  • Hereditary motor and sensory neuropathies. 
  • Heroin neuroteratogenicity: targeting adenylyl cyclase as an underlying biochemical mechanism. 
  • Herpes simplex retinitis in the mouse. Clinicopathologic correlations. 
  • Heterogeneity in MYC-induced mammary tumors contributes to escape from oncogene dependence. 
  • Heterologous immunity triggered by a single, latent virus in Mus musculus: combined costimulation- and adhesion- blockade decrease rejection. 
  • Heterotransplantation of a human prostatic adenocarcinoma cell line in nude mice. 
  • Heterotransplantation of human craniopharyngiomas in athymic "nude" mice. 
  • Heterotrimeric Galphaq11 co-immunoprecipitates with surface-anchored GRP78 from plasma membranes of alpha2M*-stimulated macrophages. 
  • Heterozygosity for Pten promotes tumorigenesis in a mouse model of medulloblastoma. 
  • Hexa-acylated lipid A is required for host inflammatory response to Neisseria gonorrhoeae in experimental gonorrhea. 
  • Hfe deficiency increases susceptibility to cardiotoxicity and exacerbates changes in iron metabolism induced by doxorubicin. 
  • Hierarchical regulation of mRNA partitioning between the cytoplasm and the endoplasmic reticulum of mammalian cells. 
  • High affinity for farnesyltransferase and alternative prenylation contribute individually to K-Ras4B resistance to farnesyltransferase inhibitors. 
  • High cholesterol feeding in C57/Blc6 mice alters expression within the VEGF receptor-ligand family in corporal tissue. 
  • High circulatory leptin mediated NOX-2-peroxynitrite-miR21 axis activate mesangial cells and promotes renal inflammatory pathology in nonalcoholic fatty liver disease. 
  • High expression of long non-coding RNA H19 is required for efficient tumorigenesis induced by Bcr-Abl oncogene. 
  • High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice. 
  • High intensity focused ultrasound-induced gene activation in solid tumors. 
  • High level expression of CD43 inhibits T cell receptor/CD3-mediated apoptosis. 
  • High levels of human gamma-globin gene expression in adult mice carrying a transgene of deletion-type hereditary persistence of fetal hemoglobin. 
  • High molecular weight extracellular proteins synthesized by endoderm cells derived from mouse teratocarcinoma cells and normal extraembryonic membranes. 
  • High mortality with severe dystrophic cardiac calcinosis in C3H/OUJ mice fed high fat purified diets. 
  • High oxygen prevents fetal lethality due to lack of catecholamines. 
  • High vascular pressure-induced lung injury requires P450 epoxygenase-dependent activation of TRPV4. 
  • High-LET Radiation Increases Tumor Progression in a K-Ras-Driven Model of Lung Adenocarcinoma. 
  • High-Throughput Odorant Receptor Deorphanization Via Phospho-S6 Ribosomal Protein Immunoprecipitation and mRNA Profiling. 
  • High-affinity inhibitors of dihydrofolate reductase: antimicrobial and anticancer activities of 7,8-dialkyl-1,3-diaminopyrrolo[3,2-f]quinazolines with small molecular size. 
  • High-affinity, protective antibodies to the binding domain of botulinum neurotoxin type A. 
  • High-density lipoprotein maintains skeletal muscle function by modulating cellular respiration in mice. 
  • High-dose 90Y Mx-diethylenetriaminepentaacetic acid (DTPA)-BrE-3 and autologous hematopoietic stem cell support (AHSCS) for the treatment of advanced breast cancer: a phase I trial. 
  • High-fat and high-sucrose (western) diet induces steatohepatitis that is dependent on fructokinase. 
  • High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. 
  • High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. 
  • High-fat/high-cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL. 
  • High-fidelity optical excitation of cortico-cortical projections at physiological frequencies. 
  • High-fidelity optical reporting of neuronal electrical activity with an ultrafast fluorescent voltage sensor. 
  • High-field (9.4 T) MRI of brain dysmyelination by quantitative mapping of magnetic susceptibility. 
  • High-frequency S-layer protein variation in Campylobacter fetus revealed by sapA mutagenesis. 
  • High-frequency alloreactive T cells augment effector function of low-frequency CD8+ T-cell responses under CD28/CD154 blockade. 
  • High-molecular-weight surface-exposed proteins of Haemophilus influenzae mediate binding to macrophages. 
  • High-resolution comparative physical mapping of mouse chromosome 10 in the region of homology with human chromosome 21. 
  • High-resolution imaging of murine myocardial infarction with delayed-enhancement cine micro-CT. 
  • High-resolution in vivo imaging of blood vessels without labeling. 
  • High-resolution magnetic resonance angiography in the mouse using a nanoparticle blood-pool contrast agent. 
  • High-resolution magnetic resonance histology of the embryonic and neonatal mouse: a 4D atlas and morphologic database. 
  • High-resolution, noninvasive longitudinal live imaging of immune responses. 
  • High-speed label-free functional photoacoustic microscopy of mouse brain in action. 
  • High-speed mapping of synaptic connectivity using photostimulation in Channelrhodopsin-2 transgenic mice. 
  • High-speed photoacoustic microscopy of mouse cortical microhemodynamics. 
  • High-speed recording of neural spikes in awake mice and flies with a fluorescent voltage sensor. 
  • High-throughput flow cytometry screening reveals a role for junctional adhesion molecule a as a cancer stem cell maintenance factor. 
  • High-throughput identification and dendritic cell-based functional validation of MHC class I-restricted Mycobacterium tuberculosis epitopes. 
  • High-throughput morphologic phenotyping of the mouse brain with magnetic resonance histology. 
  • High-throughput phenotyping of multicellular organisms: finding the link between genotype and phenotype. 
  • Higher-Order Areas of the Mouse Visual Cortex. 
  • Highly active zinc-finger nucleases by extended modular assembly. 
  • Highly conductive carbon nanotube matrix accelerates developmental chloride extrusion in central nervous system neurons by increased expression of chloride transporter KCC2. 
  • Highly coordinated gene regulation in mouse skeletal muscle regeneration. 
  • Highly divergent lentiviral Tat proteins activate viral gene expression by a common mechanism. 
  • Hippocampal long-term potentiation is normal in heme oxygenase-2 mutant mice. 
  • Hippocampal-dependent antidepressant-like activity of histone deacetylase inhibition. 
  • Histidine phosphorylation relieves copper inhibition in the mammalian potassium channel KCa3.1. 
  • Histogenesis of dieldrin and DDT-induced hepatocellular carcinoma in Balb/c mice. 
  • Histogenesis of fetal mouse isocortex and hippocampus in reaggregating cell cultures. 
  • Histological and molecular evaluation of patient-derived colorectal cancer explants. 
  • Histone H2A variants and the inactive X chromosome: identification of a second macroH2A variant. 
  • Histone H3.3K27M Represses p16 to Accelerate Gliomagenesis in a Murine Model of DIPG. 
  • Histone Methylation Dynamics and Gene Regulation Occur through the Sensing of One-Carbon Metabolism. 
  • Histone deacetylase 6 regulates growth factor-induced actin remodeling and endocytosis. 
  • Histone deacetylation critically determines T cell subset radiosensitivity. 
  • Histone modifications within the human X centromere region. 
  • Histopathologic characteristics of two forms of experimental herpes simplex virus retinitis. 
  • Hitting the reset button for immune tolerance. 
  • Hoechst dye efflux reveals a novel CD7(+)CD34(-) lymphoid progenitor in human umbilical cord blood. 
  • Homeobox genes Hoxd3 and Hoxd8 are differentially expressed in fetal mouse excisional wounds. 
  • Homeostatic mechanisms in dopamine synthesis and release: a mathematical model. 
  • Homeostatic proliferation plus regulatory T-cell depletion promotes potent rejection of B16 melanoma. 
  • Homer modulates NFAT-dependent signaling during muscle differentiation. 
  • Homer: a protein that selectively binds metabotropic glutamate receptors. 
  • Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2. 
  • Homocysteine-mediated modulation of mitochondrial dynamics in retinal ganglion cells. 
  • Hormonal gain control of a medial preoptic area social reward circuit. 
  • Hormone signaling and fatty liver in females: analysis of estrogen receptor α mutant mice. 
  • Host S-nitrosylation inhibits clostridial small molecule-activated glucosylating toxins. 
  • Host defenses against cryptococcosis. 
  • Host gene expression profiling and in vivo cytokine studies to characterize the role of linezolid and vancomycin in methicillin-resistant Staphylococcus aureus (MRSA) murine sepsis model. 
  • Host regulation of MOPC 104E plasmacytoma after reduction of tumor burden by total body irradiation. 
  • Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages. 
  • How copper traverses cellular membranes through the mammalian copper transporter 1, Ctr1. 
  • How does the mouse get its trunk? 
  • How irritating: the role of TRPA1 in sensing cigarette smoke and aerogenic oxidants in the airways. 
  • How the analysis of genetic mutations can help us to solve basic problems in gerontology? II. Life extending genetic modifications in budding yeast S. cereviseae, fruit fly D. melanogaster and laboratory mice M. musculus. 
  • How the zebrafish gets its stripes. 
  • How vinculin regulates force transmission. 
  • HoxC5 and miR-615-3p target newly evolved genomic regions to repress hTERT and inhibit tumorigenesis. 
  • Hsp90 governs echinocandin resistance in the pathogenic yeast Candida albicans via calcineurin. 
  • Hsp90 orchestrates temperature-dependent Candida albicans morphogenesis via Ras1-PKA signaling. 
  • Hub GABA neurons mediate gamma-frequency oscillations at ictal-like event onset in the immature hippocampus. 
  • Human APOE isoform-dependent effects on brain beta-amyloid levels in PDAPP transgenic mice. 
  • Human B-cell lymphoma in severe combined immunodeficient mice after active infection with Epstein-Barr virus. 
  • Human CD4+CD25low adaptive T regulatory cells suppress delayed-type hypersensitivity during transplant tolerance. 
  • Human Fungal Pathogens of Mucorales and Entomophthorales. 
  • Human G(alpha q): cDNA and tissue distribution. 
  • Human IRGM induces autophagy to eliminate intracellular mycobacteria. 
  • Human Ig knockin mice to study the development and regulation of HIV-1 broadly neutralizing antibodies. 
  • Human IgG2 constant region enhances in vivo stability of anti-tenascin antibody 81C6 compared with its murine parent. 
  • Human MafG is a functional partner for p45 NF-E2 in activating globin gene expression. 
  • Human Mesenchymal Stem Cell-Educated Macrophages Are a Distinct High IL-6-Producing Subset that Confer Protection in Graft-versus-Host-Disease and Radiation Injury Models. 
  • Human T-cell lymphotropic virus type 1 tax induction of biologically Active NF-kappaB requires IkappaB kinase-1-mediated phosphorylation of RelA/p65. 
  • Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element. 
  • Human and mouse skeletal muscle stem cells: convergent and divergent mechanisms of myogenesis. 
  • Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior. 
  • Human apoE3 but not apoE4 rescues impaired astrocyte activation in apoE null mice. 
  • Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology. 
  • Human apolipoprotein B transgenic mice generated with 207- and 145-kilobase pair bacterial artificial chromosomes. Evidence that a distant 5'-element confers appropriate transgene expression in the intestine. 
  • Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture. 
  • Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice. 
  • Human apolipoprotein E2 promotes parenchymal amyloid deposition and neuronal loss in vasculotropic mutant amyloid-β protein Tg-SwDI mice. 
  • Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice. 
  • Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model. 
  • Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid deposition. 
  • Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-β immunoreactivity after traumatic brain injury in 3xTG-AD mice. 
  • Human brain tumor xenografts. 
  • Human carbonic anhydrase-8 AAV8 gene therapy inhibits nerve growth factor signaling producing prolonged analgesia and anti-hyperalgesia in mice. 
  • Human complement factor H Y402H polymorphism causes an age-related macular degeneration phenotype and lipoprotein dysregulation in mice. 
  • Human cystic fibrosis transmembrane conductance regulator directed to respiratory epithelial cells of transgenic mice. 
  • Human equivalent of the mouse Nude/SCID phenotype: long-term evaluation of immunologic reconstitution after bone marrow transplantation. 
  • Human erythrocyte antigens. III. Characterization of a panel of murine monoclonal antibodies that react with human erythrocyte and erythroid precursor membranes. 
  • Human erythrocyte antigens. Regulation of expression of a novel erythrocyte surface antigen by the inhibitor Lutheran In(Lu) gene. 
  • Human erythrocyte antigens: II. The In(Lu) gene regulates expression of an antigen on an 80-kilodalton protein of human erythrocytes. 
  • Human galectin 3 binding protein interacts with recombinant adeno-associated virus type 6. 
  • Human gamma-satellite DNA maintains open chromatin structure and protects a transgene from epigenetic silencing. 
  • Human genetic variation in GLS2 is associated with development of complicated Staphylococcus aureus bacteremia. 
  • Human glioma-mesenchymal extracellular matrix antigen defined by monoclonal antibody. 
  • Human glycogen debranching enzyme gene (AGL): complete structural organization and characterization of the 5' flanking region. 
  • Human heat shock protein 70 (hsp70) protects murine cells from injury during metabolic stress. 
  • Human immunodeficiency virus type 1 Tat protein inhibits the SIRT1 deacetylase and induces T cell hyperactivation. 
  • Human immunodeficiency virus type 1 Vpr-binding protein VprBP, a WD40 protein associated with the DDB1-CUL4 E3 ubiquitin ligase, is essential for DNA replication and embryonic development. 
  • Human immunodeficiency virus type 1 gp41 antibodies that mask membrane proximal region epitopes: antibody binding kinetics, induction, and potential for regulation in acute infection. 
  • Human lymphocyte antigens: production of a monoclonal antibody that defines functional thymus-derived lymphocyte subsets. 
  • Human malignant and mitogen-transformed cells contain retroviral P15E-related antigen. 
  • Human melanoma growth in the peritoneal cavity of the athymic mouse--a model for in vivo study of cell-mediated immunity. 
  • Human mesenchymal stem cells exert potent antitumorigenic effects in a model of Kaposi's sarcoma. 
  • Human mononuclear phagocyte inducible nitric oxide synthase (iNOS): analysis of iNOS mRNA, iNOS protein, biopterin, and nitric oxide production by blood monocytes and peritoneal macrophages. 
  • Human natural killer cells analyzed by B73.1, a monoclonal antibody blocking Fc receptor functions. I. Characterization of the lymphocyte subset reactive with B73.1. 
  • Human ovarian cancers express somatostatin receptors. 
  • Human recombinant erythropoietin (rEpo) has no effect on tumour growth or angiogenesis. 
  • Human retrovirus-related synthetic peptides inhibit T lymphocyte proliferation. 
  • Human serum amyloid P component oligomers bind and activate the classical complement pathway via residues 14-26 and 76-92 of the A chain collagen-like region of C1q. 
  • Human sterile alpha motif domain 9, a novel gene identified as down-regulated in aggressive fibromatosis, is absent in the mouse. 
  • Human thymic epithelial cells produce granulocyte and macrophage colony-stimulating factors. 
  • Human thymic epithelial cells produce interleukin 1. 
  • Human type 2 angiotensin II receptor gene: cloned, mapped to the X chromosome, and its mRNA is expressed in the human lung. 
  • Human umbilical cord blood endothelial progenitor cells decrease vein graft neointimal hyperplasia in SCID mice. 
  • Human umbilical cord blood-derived endothelial cells reendothelialize vein grafts and prevent thrombosis. 
  • Human xenograft-nude mouse model of adoptive immunotherapy with human melanoma-specific cytotoxic T-cells. 
  • Human-chimpanzee differences in a FZD8 enhancer alter cell-cycle dynamics in the developing neocortex. 
  • Human/murine chimeric 81C6 F(ab')(2) fragment: preclinical evaluation of a potential construct for the targeted radiotherapy of malignant glioma. 
  • Humoral antibody response and tumor transplantation resistance elicited by fetal tissues in mice. 
  • Humoral autoimmunity in mice overexpressing B cell surface CD19: vital role for MHC class II. 
  • Humoral autoimmunity to basement membrane antigens is regulated in C57BL/6 and MRL/MpJ mice transgenic for anti-laminin Ig receptors. 
  • Humoral immune responses in Cr2-/- mice: enhanced affinity maturation but impaired antibody persistence. 
  • Humoral immune responses in L-selectin-deficient mice. 
  • Huntingtin is present in the nucleus, interacts with the transcriptional corepressor C-terminal binding protein, and represses transcription. 
  • Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits. 
  • Hyaluronan (HA) fragments induce chemokine gene expression in alveolar macrophages. The role of HA size and CD44. 
  • Hyaluronan contributes to bronchiolitis obliterans syndrome and stimulates lung allograft rejection through activation of innate immunity. 
  • Hyaluronan fragments activate an NF-kappa B/I-kappa B alpha autoregulatory loop in murine macrophages. 
  • Hyaluronan fragments contribute to the ozone-primed immune response to lipopolysaccharide. 
  • Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor kappaB-dependent mechanism. 
  • Hyaluronan fragments synergize with interferon-gamma to induce the C-X-C chemokines mig and interferon-inducible protein-10 in mouse macrophages. 
  • Hyaluronan mediates ozone-induced airway hyperresponsiveness in mice. 
  • Hyaluronan signaling during ozone-induced lung injury requires TLR4, MyD88, and TIRAP. 
  • Hyaluronic acid based low viscosity hydrogel as a novel carrier for Convection Enhanced Delivery of CAR T cells. 
  • Hybrid spectral CT reconstruction. 
  • Hybrid transgenic mice reveal in vivo specificity of G protein-coupled receptor kinases in the heart. 
  • Hybridization studies with a renin cDNA probe: evidence for widespread expression of renin in the mouse. 
  • Hybridoma SLE autoantibodies: insights for the pathogenesis of autoimmune disease. 
  • Hydrogel microsphere encapsulation of a cell-based gene therapy system increases cell survival of injected cells, transgene expression, and bone volume in a model of heterotopic ossification. 
  • Hydrogel-nanoparticle composites for optically modulated cancer therapeutic delivery. 
  • Hydrogels as carriers for stem cell transplantation. 
  • Hydrogen peroxide promotes aging-related platelet hyperactivation and thrombosis. 
  • Hydrolysis by somatic angiotensin-I converting enzyme of basic dipeptides from a cholecystokinin/gastrin and a LH-RH peptide extended at the C-terminus with gly-Arg/Lys-arg, but not from diarginyl insulin. 
  • Hydrolytic function of Exo1 in mammalian mismatch repair. 
  • Hydrophobic residues Phe751 and Leu753 are essential for STAT5 transcriptional activity. 
  • Hydrostatic isolated limb perfusion with adeno-associated virus vectors enhances correction of skeletal muscle in Pompe disease. 
  • Hyper-Ia antigen expression on B cells from B6-lpr/lpr mice correlates with manifestations of the autoimmune state. 
  • Hyperactive Wnt signaling changes the developmental potential of embryonic lung endoderm. 
  • Hyperactivity and cortical disinhibition in mice with restricted expression of mutant huntingtin to parvalbumin-positive cells. 
  • Hyperactivity and impaired response habituation in hyperdopaminergic mice. 
  • Hyperactivity, elevated dopaminergic transmission, and response to amphetamine in M1 muscarinic acetylcholine receptor-deficient mice. 
  • Hyperalimentation and oncologic management: update. 
  • Hyperbaric oxygen and cyclosporine as a combined treatment regimen to prevent skin allograft rejection in immunohistoincompatible mice. 
  • Hyperbaric oxygen exposures at 3 and 4 atmospheres absolute pressure for experimental gas gangrene: succinate protection against oxygen toxicity. 
  • Hyperbaric oxygen exposures for intrahepatic abscesses produced in mice by nonsporeforming anaerobic bacteria. 
  • Hypercholesterolemia Increases Colorectal Cancer Incidence by Reducing Production of NKT and γδ T Cells from Hematopoietic Stem Cells. 
  • Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells. 
  • Hyperdopaminergia and NMDA receptor hypofunction disrupt neural phase signaling. 
  • Hyperexpression of Foxp3 and IDO during acute rejection of islet allografts. 
  • Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by Vitamin B supplementation. 
  • Hyperinsulinemia in the pregnant C57BL/6J mouse. 
  • Hyperlipidemic effects of dietary saturated fats mediated through PGC-1beta coactivation of SREBP. 
  • Hyperlocomotion and indifference to cocaine and amphetamine in mice lacking the dopamine transporter. 
  • Hyperornithinaemia-hyperammonaemia-homocitrullinuria syndrome is caused by mutations in a gene encoding a mitochondrial ornithine transporter. 
  • Hyperosmotic stress stimulates promoter activity and regulates cellular utilization of the serum- and glucocorticoid-inducible protein kinase (Sgk) by a p38 MAPK-dependent pathway. 
  • Hyperoxia impairs postnatal alveolar epithelial development via NADPH oxidase in newborn mice. 
  • Hyperpolarized 3He MRI in asthma measurements of regional ventilation following allergic sensitization and challenge in mice--preliminary results. 
  • Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development. 
  • Hypertension and albuminuria in chronic kidney disease mapped to a mouse chromosome 11 locus. 
  • Hypertension and impaired glycine handling in mice lacking the orphan transporter XT2. 
  • Hypertension in CB57BL/6J mouse model of non-insulin-dependent diabetes mellitus. 
  • Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. 
  • Hyperthermia enables tumor-specific nanoparticle delivery: effect of particle size. 
  • Hyperthermia mediated liposomal drug delivery. 
  • Hyperthermia-induced enhancement of melphalan activity against a melphalan-resistant human rhabdomyosarcoma xenograft. 
  • Hyperthermic effects on behavior. 
  • Hyperthermic modulation of radiolabelled antibody uptake in a human glioma xenograft and normal tissues. 
  • Hypertonicity sensing in organum vasculosum lamina terminalis neurons: a mechanical process involving TRPV1 but not TRPV4. 
  • Hypertrophic cardiomyopathy in cardiac myosin binding protein-C knockout mice. 
  • Hypervirulent group A Streptococcus emergence in an acaspular background is associated with marked remodeling of the bacterial cell surface. 
  • Hypo-CpG methylation controls PTEN expression and cell apoptosis in irradiated lung. 
  • Hypolipidemic activity of boronated nucleosides and nucleotides in rodents. 
  • Hypolipidemic activity of tetrakis-mu-(trimethylamine-borane