Focal Adhesion Kinase 2
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Subject Areas on Research
- CD28 ligation induces tyrosine phosphorylation of Pyk2 but not Fak in Jurkat T cells.
- Calcium/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses.
- Glucose activates mitogen-activated protein kinase (extracellular signal-regulated kinase) through proline-rich tyrosine kinase-2 and the Glut1 glucose transporter.
- ICAM-1-mediated, Src- and Pyk2-dependent vascular endothelial cadherin tyrosine phosphorylation is required for leukocyte transendothelial migration.
- Inhibition of vascular smooth muscle cell proliferation, migration, and survival by the tumor suppressor protein PTEN.
- Luminal alkalinization attenuates proteinuria-induced oxidative damage in proximal tubular cells.
- Pleiotropic coupling of G protein-coupled receptors to the mitogen-activated protein kinase cascade. Role of focal adhesions and receptor tyrosine kinases.
- Probing the role of PPARγ in the regulation of late-onset Alzheimer's disease-associated genes.
- Regulation of CDC42 GTPase by proline-rich tyrosine kinase 2 interacting with PSGAP, a novel pleckstrin homology and Src homology 3 domain containing rhoGAP protein.
- Regulation of T cell receptor- and CD28-induced tyrosine phosphorylation of the focal adhesion tyrosine kinases Pyk2 and Fak by protein kinase C. A role for protein tyrosine phosphatases.
- SOCS3 inhibiting migration of A549 cells correlates with PYK2 signaling in vitro.
- T cell activation up-regulates the expression of the focal adhesion kinase Pyk2: opposing roles for the activation of protein kinase C and the increase in intracellular Ca2+.
- Up-regulation of proline-rich tyrosine kinase 2 in non-small cell lung cancer.