Hepatocyte Nuclear Factor 3-alpha
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Subject Areas on Research
- Androgen receptor regulates a distinct transcription program in androgen-independent prostate cancer.
- Comprehensive Molecular Portraits of Invasive Lobular Breast Cancer.
- Definition of a FoxA1 Cistrome that is crucial for G1 to S-phase cell-cycle transit in castration-resistant prostate cancer.
- Delineation of a FOXA1/ERα/AGR2 regulatory loop that is dysregulated in endocrine therapy-resistant breast cancer.
- Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.
- Foxa1-deficient mice exhibit impaired insulin secretion due to uncoupled oxidative phosphorylation.
- Genome-wide analysis reveals positional-nucleosome-oriented binding pattern of pioneer factor FOXA1.
- Integrated analysis identifies a class of androgen-responsive genes regulated by short combinatorial long-range mechanism facilitated by CTCF.
- Integrated cistromic and expression analysis of amplified NKX2-1 in lung adenocarcinoma identifies LMO3 as a functional transcriptional target.
- Integrative analysis identifies targetable CREB1/FoxA1 transcriptional co-regulation as a predictor of prostate cancer recurrence.
- New insights into human female reproductive tract development.
- Shaping Chromatin States in Prostate Cancer by Pioneer Transcription Factors.
- The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer.
- Three-tiered role of the pioneer factor GATA2 in promoting androgen-dependent gene expression in prostate cancer.