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Subject Areas on Research
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3,4-Diaryl-5-hydroxyfuranones: highly selective inhibitors of cyclooxygenase-2 with aqueous solubility.
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A common polymorphism in the 3'UTR of cyclooxygenase 2/prostaglandin synthase 2 gene and risk of lung cancer in a Chinese population.
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A major role for the EP4 receptor in regulation of renin.
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A new prostate cancer therapeutic approach: combination of androgen ablation with COX-2 inhibitor.
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A new structural variation on the methanesulfonylphenyl class of selective cyclooxygenase-2 inhibitors.
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A selective inhibitor of cyclooxygenase-2 reverses endotoxin-induced pyretic responses in non-human primates.
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ATP modulates load-inducible IL-1beta, COX 2, and MMP-3 gene expression in human tendon cells.
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Aberrant monocyte prostaglandin synthase 2 (PGS2) expression in type 1 diabetes before and after disease onset.
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Acute urinary retention associated with the use of cyclooxygenase-2 inhibitors.
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Agathisflavone isolated from Anacardium occidentale suppresses SIRT1-mediated neuroinflammation in BV2 microglia and neurotoxicity in APPSwe-transfected SH-SY5Y cells.
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Airway inflammation and responsiveness in prostaglandin H synthase-deficient mice exposed to bacterial lipopolysaccharide.
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Akt expression may predict favorable prognosis in cholangiocarcinoma.
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Anovulation in cyclooxygenase-2-deficient mice is restored by prostaglandin E2 and interleukin-1beta.
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Anti-inflammatory effects of inhibiting the amine oxidase activity of semicarbazide-sensitive amine oxidase.
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Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia.
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Antimalarial Drug Artemether Inhibits Neuroinflammation in BV2 Microglia Through Nrf2-Dependent Mechanisms.
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Aspirin resistance.
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Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor.
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Biological effects of desert dust in respiratory epithelial cells and a murine model.
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Breaking barriers for T cells by targeting the EPHA2/TGF-β/COX-2 axis in pancreatic cancer.
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COX-2 inhibitors.
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COX-2 polymorphism, use of nonsteroidal anti-inflammatory drugs, and risk of colon cancer in African Americans (United States).
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COX-2-derived prostacyclin modulates vascular remodeling.
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Calcineurin (CN) activation promotes apoptosis of glomerular podocytes both in vitro and in vivo.
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Celecoxib With Neoadjuvant Chemotherapy for Breast Cancer Might Worsen Outcomes Differentially by COX-2 Expression and ER Status: Exploratory Analysis of the REMAGUS02 Trial.
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Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues.
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Cell cycle effects of nonsteroidal anti-inflammatory drugs and enhanced growth inhibition in combination with gemcitabine in pancreatic carcinoma cells.
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Cell-extrinsic consequences of epithelial stress: activation of protumorigenic tissue phenotypes.
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Central nervous system concentrations of cyclooxygenase-2 inhibitors in humans.
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Chemokine CXCL1 enhances inflammatory pain and increases NMDA receptor activity and COX-2 expression in spinal cord neurons via activation of CXCR2.
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Combination therapy with sorafenib and celecoxib for pediatric patients with desmoid tumor.
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Compensatory hypertrophy induced by ventricular cardiomyocyte-specific COX-2 expression in mice.
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Cyclo-oxygenase 2, a putative mediator of vessel remodeling, is expressed in the brain AVM vessels and associates with inflammation.
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Cyclooxygenase 2 polymorphism (Val511Ala), nonsteroidal anti-inflammatory drug use and breast cancer in African American women.
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Cyclooxygenase-1 and -2 knockout mice demonstrate increased cardiac ischemia/reperfusion injury but are protected by acute preconditioning.
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Cyclooxygenase-2 (COX-2) as a predictive marker for the use of COX-2 inhibitors in advanced non-small-cell lung cancer.
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Cyclooxygenase-2 (COX-2) levels before and after chemotherapy: a study in rectal cancer.
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Cyclooxygenase-2 is a novel transcriptional target of the nuclear EGFR-STAT3 and EGFRvIII-STAT3 signaling axes.
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Cyclooxygenase-2 overexpression correlates with tumour recurrence, especially haematogenous metastasis, of colorectal cancer.
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Cyclooxygenase-two (COX-2) modulates proliferation in aggressive fibromatosis (desmoid tumor).
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DIO2 modifies inflammatory responses in chondrocytes.
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Deficiency of either cyclooxygenase (COX)-1 or COX-2 alters epidermal differentiation and reduces mouse skin tumorigenesis.
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Diagnostics for aspirin resistance.
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Differential Sex Response to Aspirin in Decreasing Aneurysm Rupture in Humans and Mice.
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Differential regulation of renin and Cox-2 expression in the renal cortex of C57Bl/6 mice.
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Dying glioma cells establish a proangiogenic microenvironment through a caspase 3 dependent mechanism.
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E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation.
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Early change in ferumoxytol-enhanced magnetic resonance imaging signal suggests unstable human cerebral aneurysm: a pilot study.
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Effect of size fractionation on the toxicity of amosite and Libby amphibole asbestos.
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Effects of sphingosine-1-phosphate and ceramide-1-phosphate on rat intestinal smooth muscle cells: implications for postoperative ileus.
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Eicosanoid modulation in advanced lung cancer: cyclooxygenase-2 expression is a positive predictive factor for celecoxib + chemotherapy--Cancer and Leukemia Group B Trial 30203.
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Eicosanoids: lipid mediators of inflammation in transplantation.
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Elevation of cardiovascular risk by non-steroidal anti-inflammatory drugs.
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Endocannabinoid regulation in human endometrium across the menstrual cycle.
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Enhanced lithium-induced brain recovery following cranial irradiation is not impeded by inflammation.
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Estrogen up-regulates cyclooxygenase-2 via estrogen receptor in human uterine microvascular endothelial cells.
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Evidence for a pro-proliferative feedback loop in prostate cancer: the role of Epac1 and COX-2-dependent pathways.
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Evidence that acetylsalicylic acid attenuates inflammation in the walls of human cerebral aneurysms: preliminary results.
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Expression of integrin α3β1 and cyclooxygenase-2 (COX2) are positively correlated in human breast cancer.
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First evidence that γ-tocotrienol inhibits the growth of human gastric cancer and chemosensitizes it to capecitabine in a xenograft mouse model through the modulation of NF-κB pathway.
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Flavanones structure-related inhibition on TPA-induced tumor promotion through suppression of extracellular signal-regulated protein kinases: involvement of prostaglandin E2 in anti-promotive process.
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Genetic Variants in Cyclooxygenase-2 Contribute to Post-treatment Pain among Endodontic Patients.
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Gq-dependent signaling upregulates COX2 in glomerular podocytes.
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Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages.
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Hypoxia in the thymus: role of oxygen tension in thymocyte survival.
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IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells.
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Impaired systemic production of prostaglandin E2 in children with cerebral malaria.
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In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production.
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In vitro metabolism of the COX-2 inhibitor DFU, including a novel glutathione adduct rearomatization.
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Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway.
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Induction of cyclooxygenase-2 in human endometrial stromal cells by malignant endometrial epithelial cells: evidence for the involvement of extracellularly regulated kinases and CCAAT/enhancer binding proteins.
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Induction of cyclooxygenase-2 synthesis by ligation of the macrophage alpha(2)-macroglobulin signalling receptor.
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Inhibition of haematogenous metastasis of colon cancer in mice by a selective COX-2 inhibitor, JTE-522.
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Inhibition of neuroinflammation in BV2 microglia by the biflavonoid kolaviron is dependent on the Nrf2/ARE antioxidant protective mechanism.
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Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages.
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Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.
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Interleukin-1beta elevates cyclooxygenase-2 protein level and enzyme activity via increasing its mRNA stability in human endometrial stromal cells: an effect mediated by extracellularly regulated kinases 1 and 2.
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Inverse relationship of plasma prostaglandin E2 and blood mononuclear cell cyclooxygenase-2 with disease severity in children with Plasmodium falciparum malaria.
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Lack of correlation between the central anti-nociceptive and peripheral anti-inflammatory effects of selective COX-2 inhibitor parecoxib.
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Lactobacillus rhamnosus GG and Bifidobacterium longum attenuate lung injury and inflammatory response in experimental sepsis.
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MAPK-activated protein kinase-2 in cardiac hypertrophy and cyclooxygenase-2 regulation in heart.
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Marine ω-3 Polyunsaturated Fatty Acid and Fish Intake after Colon Cancer Diagnosis and Survival: CALGB 89803 (Alliance).
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Mast cells are critical for protection against peptic ulcers induced by the NSAID piroxicam.
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Mathematical modeling of the Phoenix Rising pathway.
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Matrix-based Molecular Descriptors for Prospective Virtual Compound Screening.
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Metabolism of PGE2 by prostaglandin dehydrogenase is essential for remodeling the ductus arteriosus.
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Microparticles stimulate the synthesis of prostaglandin E(2) via induction of cyclooxygenase 2 and microsomal prostaglandin E synthase 1.
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Modulation of eicosanoid metabolism in endothelial cells in a xenograft model. Role of cyclooxygenase-2.
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Neonatal bacterial infection alters fever to live and simulated infections in adulthood.
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Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation.
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Nonsteroidal antiinflammatory drug use among patients with GI bleeding.
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Nuclear factor kappa B activation is a potential target for preventing pancreatic carcinoma by aspirin.
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Obesogenic high-fat diet heightens aerobic glycolysis through hyperactivation of oncogenic KRAS.
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Overexpression of human catalase inhibits proliferation and promotes apoptosis in vascular smooth muscle cells.
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Pathogenesis of radiation-induced capsular contracture in tissue expander and implant breast reconstruction.
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Perioperative COX-2 inhibitors: knowledge and challenges.
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Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production.
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Phase II trial of curcumin in patients with advanced pancreatic cancer.
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Phase III Randomized, Placebo-Controlled, Double-Blind Trial of Celecoxib in Addition to Standard Chemotherapy for Advanced Non-Small-Cell Lung Cancer With Cyclooxygenase-2 Overexpression: CALGB 30801 (Alliance).
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Phenotypic abnormalities in macrophages from leptin-deficient, obese mice.
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Phosphorylated epidermal growth factor receptor and cyclooxygenase-2 expression in localized non-small cell lung cancer.
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Photoperiod alters the time course of brain cyclooxygenase-2 expression in Siberian hamsters.
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Podocyte-specific knockout of cyclooxygenase 2 exacerbates diabetic kidney disease.
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Pomegranate inhibits neuroinflammation and amyloidogenesis in IL-1β-stimulated SK-N-SH cells.
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Preserved heart function and maintained response to cardiac stresses in a genetic model of cardiomyocyte-targeted deficiency of cyclooxygenase-2.
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Production of prostaglandin E₂ in response to infection with modified vaccinia Ankara virus.
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Prognostic association of PTGS2 (COX-2) over-expression according to BRAF mutation status in colorectal cancer: Results from two prospective cohorts and CALGB 89803 (Alliance) trial.
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Proinflammatory cytokines and ARDS pulmonary edema fluid induce CD40 on human mesenchymal stromal cells-A potential mechanism for immune modulation.
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Punicalagin inhibits neuroinflammation in LPS-activated rat primary microglia.
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Pyridazinones as selective cyclooxygenase-2 inhibitors.
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Quantifying intrinsic specificity: a potential complement to affinity in drug screening.
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ROC curve estimation under test-result-dependent sampling.
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Recombinant human endostatin could eliminate the pro-angiogenesis priority of SP cells sorted from non-small cell lung cancer cells.
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Reduced peripheral PGE2 biosynthesis in Plasmodium falciparum malaria occurs through hemozoin-induced suppression of blood mononuclear cell cyclooxygenase-2 gene expression via an interleukin-10-independent mechanism.
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Reduced spontaneous relaxation in immature guinea pig airway smooth muscle is associated with increased prostanoid release.
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Reduction of spinal PGE2 concentrations prevents swim stress-induced thermal hyperalgesia.
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Resistance to hypertension mediated by intercalated cells of the collecting duct.
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Rofecoxib [Vioxx, MK-0966; 4-(4'-methylsulfonylphenyl)-3-phenyl-2-(5H)-furanone]: a potent and orally active cyclooxygenase-2 inhibitor. Pharmacological and biochemical profiles.
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Role of mitogen-activated protein kinase in osteoblast differentiation.
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Role of prostacyclin in the cardiovascular response to thromboxane A2.
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SIRT1 plays an important role in implantation and decidualization during mouse early pregnancy.
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Selenomethionine inhibits IL-1β inducible nitric oxide synthase (iNOS) and cyclooxygenase 2 (COX2) expression in primary human chondrocytes.
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Serum vascular endothelial growth factor and COX-2/5-LOX inhibition in advanced non-small cell lung cancer: Cancer and Leukemia Group B 150304.
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Skin tight: macrophage-specific COX-2 induction links salt handling in kidney and skin.
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Suppression of prostaglandin E2 by malaria parasite products and antipyretics promotes overproduction of tumor necrosis factor-alpha: association with the pathogenesis of childhood malarial anemia.
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Susceptibility of cyclooxygenase-2-deficient mice to pulmonary fibrogenesis.
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Sustained adrenergic signaling leads to increased metastasis in ovarian cancer via increased PGE2 synthesis.
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Synthesis and biological evaluation of 3-heteroaryloxy-4-phenyl-2(5H)-furanones as selective COX-2 inhibitors.
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Synthesis, characterization, and activity of metabolites derived from the cyclooxygenase-2 inhibitor rofecoxib (MK-0966, Vioxx).
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TAB-1 modulates intracellular localization of p38 MAP kinase and downstream signaling.
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The EP4 receptor for prostaglandin E2 in glomerular disease: a good receptor turned bad?
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The Role of Progesterone and a Novel Progesterone Receptor, Progesterone Receptor Membrane Component 1, in the Inflammatory Response of Fetal Membranes to Ureaplasma parvum Infection.
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The discovery of rofecoxib, [MK 966, Vioxx, 4-(4'-methylsulfonylphenyl)-3-phenyl-2(5H)-furanone], an orally active cyclooxygenase-2-inhibitor.
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The effect of celecoxib, a cyclooxygenase-2 inhibitor, in familial adenomatous polyposis.
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The effects of physician specialty and patient comorbidities on the use and discontinuation of coxibs.
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The role of COX-2 in heart pathology.
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Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli.
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Up-regulation of cyclooxygenase-2 expression and prostaglandin synthesis in endometrial stromal cells by malignant endometrial epithelial cells. A paracrine effect mediated by prostaglandin E2 and nuclear factor-kappa B.
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Upregulation of cyclooxygenase-2 (COX-2) and microsomal prostaglandin E2 synthase-1 (mPGES-1) in wall of ruptured human cerebral aneurysms: preliminary results.
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Vascular endothelial growth factor up-regulates cyclooxygenase-2 expression in human endothelial cells.