I-kappa B Kinase

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  Subject Areas on Research

  • A nonsense mutation in IKBKB causes combined immunodeficiency. 
  • Canonical transient receptor potential 3 channels activate NF-κB to mediate allergic airway disease via PKC-α/IκB-α and calcineurin/IκB-β pathways. 
  • Chronic activation of the kinase IKKβ impairs T cell function and survival. 
  • Effects of the NIK aly mutation on NF-kappaB activation by the Epstein-Barr virus latent infection membrane protein, lymphotoxin beta receptor, and CD40. 
  • Epstein-Barr virus latent infection membrane protein 1 TRAF-binding site induces NIK/IKK alpha-dependent noncanonical NF-kappaB activation. 
  • Frequent engagement of the classical and alternative NF-kappaB pathways by diverse genetic abnormalities in multiple myeloma. 
  • IKKα negatively regulates ASC-dependent inflammasome activation. 
  • IKKβ promotes metabolic adaptation to glutamine deprivation via phosphorylation and inhibition of PFKFB3. 
  • Imidazo[4,5-d]thiazolo[5,4-b]pyridine based inhibitors of IKK2: synthesis, SAR, PK/PD and activity in a preclinical model of rheumatoid arthritis. 
  • Integrative genomic approaches identify IKBKE as a breast cancer oncogene. 
  • MxA suppresses TAK1-IKKα/β-NF-κB mediated inflammatory cytokine production to facilitate Mycobacterium tuberculosis infection. 
  • NF-kappaB and AP-1 connection: mechanism of NF-kappaB-dependent regulation of AP-1 activity. 
  • NF-κB- and AP-1-mediated DNA looping regulates osteopontin transcription in endotoxin-stimulated murine macrophages. 
  • Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis. 
  • Oncogenic CARD11 mutations in human diffuse large B cell lymphoma. 
  • Persistent nuclear factor-kappa B activation in Ucp2-/- mice leads to enhanced nitric oxide and inflammatory cytokine production. 
  • Potential role of Hedgehog signaling and microRNA-29 in liver fibrosis of IKKβ-deficient mouse. 
  • Preclinical developments in type 2 diabetes. 
  • Protein kinase C-zeta is critical in pancreatitis-induced apoptosis of Kupffer cells. 
  • RelB modulation of IkappaBalpha stability as a mechanism of transcription suppression of interleukin-1alpha (IL-1alpha), IL-1beta, and tumor necrosis factor alpha in fibroblasts. 
  • Resolving postoperative neuroinflammation and cognitive decline. 
  • Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain). 
  • S-nitrosylation: physiological regulation of NF-kappaB. 
  • SYT-SSX1 (synovial sarcoma translocated) regulates PIASy ligase activity to cause overexpression of NCOA3 protein. 
  • Signals from dying hepatocytes trigger growth of liver progenitors. 
  • Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB. 
  • Synthesis, initial SAR and biological evaluation of 1,6-dihydroimidazo[4,5-d]pyrrolo[2,3-b]pyridin-4-amine derived inhibitors of IkappaB kinase. 
  • The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to Citrobacter rodentium in colonic epithelial cells by preventing NF-kappaB activation. 
  • The multisubunit IkappaB kinase complex shows random sequential kinetics and is activated by the C-terminal domain of IkappaB alpha. 
  • Toll-like receptors in the pathogenesis of human disease. 
  • Ubiquitylated Tax targets and binds the IKK signalosome at the centrosome. 
  • [Inflammatory stage of incontinentia pigmenti (Bloch-Sulzberger syndrome)]. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology