KCNQ3 Potassium Channel

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  Subject Areas on Research

  • A common ankyrin-G-based mechanism retains KCNQ and NaV channels at electrically active domains of the axon. 
  • Autism and developmental disability caused by KCNQ3 gain-of-function variants. 
  • In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models. 
  • N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator.