MutS Homolog 2 Protein

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  Subject Areas on Research

  • A novel mouse model of cerebral cavernous malformations based on the two-hit mutation hypothesis recapitulates the human disease. 
  • A phase II window trial of procarbazine and topotecan in children with high-grade glioma: a report from the children's oncology group. 
  • A prospective prostate cancer screening programme for men with pathogenic variants in mismatch repair genes (IMPACT): initial results from an international prospective study. 
  • Analysis of DNA mismatch repair proteins in human medulloblastoma. 
  • Analysis of the excision step in human DNA mismatch repair. 
  • Analysis of the proteins involved in the in vivo repair of base-base mismatches and four-base loops formed during meiotic recombination in the yeast Saccharomyces cerevisiae. 
  • Association of family history with cancer recurrence and survival among patients with stage III colon cancer. 
  • Biochemical correlates of temozolomide sensitivity in pediatric solid tumor xenograft models. 
  • Caenorhabditis elegans DNA mismatch repair gene msh-2 is required for microsatellite stability and maintenance of genome integrity. 
  • Correlation between germline mutations in MMR genes and microsatellite instability in ovarian cancer specimens. 
  • DNA chain length dependence of formation and dynamics of hMutSalpha.hMutLalpha.heteroduplex complexes. 
  • Differential specificities and simultaneous occupancy of human MutSalpha nucleotide binding sites. 
  • Expression of five selected human mismatch repair genes simultaneously detected in normal and cancer cell lines by a nonradioactive multiplex reverse transcription-polymerase chain reaction. 
  • Factors enforcing the species boundary between the human pathogens Cryptococcus neoformans and Cryptococcus deneoformans. 
  • Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. 
  • Frameshift intermediates in homopolymer runs are removed efficiently by yeast mismatch repair proteins. 
  • Frequency of mutations in mismatch repair genes in a population-based study of women with ovarian cancer. 
  • Genetic analysis of sinonasal adenocarcinoma phenotypes: distinct alterations of histogenetic significance. 
  • Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer. 
  • HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression. 
  • Hereditary prostate cancer as a feature of Lynch syndrome. 
  • Isolation and characterization of point mutations in mismatch repair genes that destabilize microsatellites in yeast. 
  • Isolation of MutSbeta from human cells and comparison of the mismatch repair specificities of MutSbeta and MutSalpha. 
  • MSH6, a Saccharomyces cerevisiae protein that binds to mismatches as a heterodimer with MSH2. 
  • Meiotic recombination involving heterozygous large insertions in Saccharomyces cerevisiae: formation and repair of large, unpaired DNA loops. 
  • Microsatellite instability in gynecological sarcomas and in hMSH2 mutant uterine sarcoma cell lines defective in mismatch repair activity. 
  • Mismatch repair and nucleotide excision repair proteins cooperate in the recognition of DNA interstrand crosslinks. 
  • Mouse embryonic stem cells carrying one or two defective Msh2 alleles respond abnormally to oxidative stress inflicted by low-level radiation. 
  • Natural mismatch repair mutations mediate phenotypic diversity and drug resistance in Cryptococcus deuterogattii. 
  • Origins and prevalence of the American Founder Mutation of MSH2. 
  • Pembrolizumab in men with heavily treated metastatic castrate-resistant prostate cancer. 
  • Purification, crystallization and preliminary X-ray diffraction analysis of the human mismatch repair protein MutSβ. 
  • Recognition and repair of compound DNA lesions (base damage and mismatch) by human mismatch repair and excision repair systems. 
  • Reduced expression of hMSH2 and hMLH1 and risk of prostate cancer: a case-control study. 
  • Reduced expression of mismatch repair genes in colorectal cancer patients in Egypt. 
  • Reduced expression of mismatch repair genes measured by multiplex reverse transcription-polymerase chain reaction in human gliomas. 
  • Removal of frameshift intermediates by mismatch repair proteins in Saccharomyces cerevisiae. 
  • Repair of DNA loops involves DNA-mismatch and nucleotide-excision repair proteins. 
  • Role of mismatch repair in the fidelity of RAD51- and RAD59-dependent recombination in Saccharomyces cerevisiae. 
  • Sequence composition and context effects on the generation and repair of frameshift intermediates in mononucleotide runs in Saccharomyces cerevisiae. 
  • Single-amplicon MSH2 A636P mutation testing in Ashkenazi Jewish patients with colorectal cancer: role in presurgical management. 
  • Somatic deletions of genes regulating MSH2 protein stability cause DNA mismatch repair deficiency and drug resistance in human leukemia cells. 
  • Targeting methylguanine-DNA methyltransferase in the treatment of neuroblastoma. 
  • The MutSalpha-proliferating cell nuclear antigen interaction in human DNA mismatch repair. 
  • The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase. 
  • Uncertainty in the utility of immunohistochemistry in mismatch repair protein expression in epithelial ovarian cancer. 
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  Keywords of People

  • Berchuck, Andrew, James M. Ingram Distinguished Professor of Gynecologic Oncology, Obstetrics and Gynecology, Gynecologic Oncology
  • McLendon, Roger Edwin, Professor of Pathology, Pathology