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Subject Areas on Research
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ADAM metallopeptidase domain 17 (ADAM17) is naturally processed through major histocompatibility complex (MHC) class I molecules and is a potential immunotherapeutic target in breast, ovarian and prostate cancers.
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ADAM10 is essential for proteolytic activation of Notch during thymocyte development.
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ADAM12: a genetic modifier of preclinical peripheral arterial disease.
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ADAM9 inhibition increases membrane activity of ADAM10 and controls α-secretase processing of amyloid precursor protein.
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ADAMTS metalloproteases generate active versican fragments that regulate interdigital web regression.
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Adam10 is essential for early embryonic cardiovascular development.
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Cartilage viability and catabolism in the intact porcine knee following transarticular impact loading with and without articular fracture.
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Characterization of and osteoarthritis susceptibility in ADAMTS-4-knockout mice.
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Diacetyl induces amphiregulin shedding in pulmonary epithelial cells and in experimental bronchiolitis obliterans.
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IL-1 beta induces COX2, MMP-1, -3 and -13, ADAMTS-4, IL-1 beta and IL-6 in human tendon cells.
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Identification of an ADAMTS-4 cleavage motif using phage display leads to the development of fluorogenic peptide substrates and reveals matrilin-3 as a novel substrate.
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Identification of candidate substrates for ectodomain shedding by the metalloprotease-disintegrin ADAM8.
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Is it quinine TTP/HUS or quinine TMA? ADAMTS13 levels and implications for therapy.
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Modulating hedgehog signaling can attenuate the severity of osteoarthritis.
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Monitoring changes in gene expression in renal ischemia-reperfusion in the rat.
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Mutations near amino end of alpha1(I) collagen cause combined osteogenesis imperfecta/Ehlers-Danlos syndrome by interference with N-propeptide processing.
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Regulation of Cholesterol Homeostasis by Hedgehog Signaling in Osteoarthritic Cartilage.
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Relapse of thrombotic thrombocytopenic purpura: is it a continuum of disease?
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Screen and identification of proteins interacting with ADAM19 cytoplasmic tail.
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Stall encodes an ADAMTS metalloprotease and interacts genetically with Delta in Drosophila ovarian follicle formation.
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The ADAM10 prodomain is a specific inhibitor of ADAM10 proteolytic activity and inhibits cellular shedding events.
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The low affinity IgE receptor (CD23) is cleaved by the metalloproteinase ADAM10.
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The secreted metalloprotease ADAMTS20 is required for melanoblast survival.
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Thrombotic thrombocytopenic purpura: 2012 American Society for Apheresis (ASFA) consensus conference on classification, diagnosis, management, and future research.
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Ticlopidine- and clopidogrel-associated thrombotic thrombocytopenic purpura (TTP): review of clinical, laboratory, epidemiological, and pharmacovigilance findings (1989-2008).
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Ticlopidine-associated ADAMTS13 activity deficient thrombotic thrombocytopenic purpura in 22 persons in Japan: a report from the Southern Network on Adverse Reactions (SONAR).