Origin Recognition Complex

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  Subject Areas on Research

  • Chromatin signatures of the Drosophila replication program. 
  • Coordination of replication and transcription along a Drosophila chromosome. 
  • Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading. 
  • Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly. 
  • Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation. 
  • Integrative analysis of gene amplification in Drosophila follicle cells: parameters of origin activation and repression. 
  • ORChestrating the human DNA replication program. 
  • Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1. 
  • The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin. 
  • Visualization of replication initiation and elongation in Drosophila. 
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  Keywords of People

  • Gordan, Raluca Mihaela, Assistant Professor in Biostatistics & Bioinformatics, Computer Science
  • Hartemink, Alexander J., Professor in the Department of Computer Science, Biology