Origin Recognition Complex
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Subject Areas on Research
- Cell cycle: Flies teach an old dogma new tricks.
- Chromatin signatures of the Drosophila replication program.
- Coordination of replication and transcription along a Drosophila chromosome.
- Drosophila ORC localizes to open chromatin and marks sites of cohesin complex loading.
- Expression of the HsOrc1 gene, a human ORC1 homolog, is regulated by cell proliferation via the E2F transcription factor.
- Functions of fission yeast orp2 in DNA replication and checkpoint control.
- Genome-wide chromatin footprinting reveals changes in replication origin architecture induced by pre-RC assembly.
- Human origin recognition complex large subunit is degraded by ubiquitin-mediated proteolysis after initiation of DNA replication.
- Identification of E2F target genes that are rate limiting for dE2F1-dependent cell proliferation.
- Integrative analysis of gene amplification in Drosophila follicle cells: parameters of origin activation and repression.
- ORChestrating the human DNA replication program.
- Replication factors MCM2 and ORC1 interact with the histone acetyltransferase HBO1.
- The conserved bromo-adjacent homology domain of yeast Orc1 functions in the selection of DNA replication origins within chromatin.
- Two-faced cyclins with eyes on the targets.
- Visualization of replication initiation and elongation in Drosophila.
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Keywords of People
- Gordan, Raluca Mihaela, Associate Professor in Biostatistics & Bioinformatics, Molecular Genetics and Microbiology
- Hartemink, Alexander J., Professor in the Department of Computer Science, Biology