ZAP-70 Protein-Tyrosine Kinase
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Subject Areas on Research
- A single tube, four-color flow cytometry assay for evaluation of ZAP-70 and CD38 expression in chronic lymphocytic leukemia.
- CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation.
- CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor.
- Clinical and molecular predictors of disease severity and survival in chronic lymphocytic leukemia.
- Clinical characteristics, response to therapy, and survival of African American patients diagnosed with chronic lymphocytic leukemia: joint experience of the MD Anderson Cancer Center and Duke University Medical Center.
- Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.
- Genomic complexity identifies patients with aggressive chronic lymphocytic leukemia.
- HIV infection--induced posttranslational modification of T cell signaling molecules associated with disease progression.
- Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development.
- LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
- LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
- Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein.
- Requirement for Abl kinases in T cell receptor signaling.
- Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation.
- Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination.
- T cell activation deficiency associated with an aberrant pattern of protein tyrosine phosphorylation after CD3 perturbation in Down's syndrome.
- ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis.
- ZAP-70-dependent and -independent activation of Erk in Jurkat T cells. Differences in signaling induced by H2o2 and Cd3 cross-linking.
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Keywords of People
- Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, Immunology