ZAP-70 Protein-Tyrosine Kinase

• 

  Subject Areas on Research

  • A single tube, four-color flow cytometry assay for evaluation of ZAP-70 and CD38 expression in chronic lymphocytic leukemia. 
  • CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation. 
  • CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor. 
  • Clinical and molecular predictors of disease severity and survival in chronic lymphocytic leukemia. 
  • Genomic complexity identifies patients with aggressive chronic lymphocytic leukemia. 
  • HIV infection--induced posttranslational modification of T cell signaling molecules associated with disease progression. 
  • Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development. 
  • Requirement for Abl kinases in T cell receptor signaling. 
  • T cell activation deficiency associated with an aberrant pattern of protein tyrosine phosphorylation after CD3 perturbation in Down's syndrome. 
• 

  Keywords of People

  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine, Immunology