ZAP-70 Protein-Tyrosine Kinase

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  Subject Areas on Research

  • A single tube, four-color flow cytometry assay for evaluation of ZAP-70 and CD38 expression in chronic lymphocytic leukemia. 
  • CD28 ligation induces rapid tyrosine phosphorylation of the linker molecule LAT in the absence of Syk and ZAP-70 tyrosine phosphorylation. 
  • CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor. 
  • Clinical and molecular predictors of disease severity and survival in chronic lymphocytic leukemia. 
  • Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line. 
  • Genomic complexity identifies patients with aggressive chronic lymphocytic leukemia. 
  • HIV infection--induced posttranslational modification of T cell signaling molecules associated with disease progression. 
  • Human syndromes of immunodeficiency and dysregulation are characterized by distinct defects in T-cell receptor repertoire development. 
  • LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. 
  • LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. 
  • Regulation of ZAP-70 intracellular localization: visualization with the green fluorescent protein. 
  • Requirement for Abl kinases in T cell receptor signaling. 
  • Signaling via LAT (linker for T-cell activation) and Syk/ZAP70 is required for ERK activation and NFAT transcriptional activation following CD2 stimulation. 
  • T cell activation deficiency associated with an aberrant pattern of protein tyrosine phosphorylation after CD3 perturbation in Down's syndrome. 
  • ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis. 
  • ZAP-70-dependent and -independent activation of Erk in Jurkat T cells. Differences in signaling induced by H2o2 and Cd3 cross-linking. 
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  Keywords of People

  • Weinhold, Kent James, Joseph W. and Dorothy W. Beard Professor of Experimental Surgery, in the School of Medicine, Immunology