Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Subject Areas on Research
- A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism.
- A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.
- Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation.
- Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells.
- B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.
- ChREBP regulates fructose-induced glucose production independently of insulin signaling.
- Clinical application of exome sequencing in undiagnosed genetic conditions.
- Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
- Epstein-Barr virus induces global changes in cellular mRNA isoform usage that are important for the maintenance of latency.
- Expansion of CTG18.1 Trinucleotide Repeat in TCF4 Is a Potent Driver of Fuchs' Corneal Dystrophy.
- Genomic regions flanking E-box binding sites influence DNA binding specificity of bHLH transcription factors through DNA shape.
- Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.
- Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans.
- Immunocytochemistry for SOX-11 and TFE3 as diagnostic markers for solid pseudopapillary neoplasms of the pancreas in FNA biopsies.
- Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation.
- Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4.
- Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer.
- Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA.
- Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis.
- MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB.
- Mitochondrial polymorphism A10398G and Haplogroup I are associated with Fuchs' endothelial corneal dystrophy.
- Mutations in AGBL1 cause dominant late-onset Fuchs corneal dystrophy and alter protein-protein interaction with TCF4.
- Nomenclature: vertebrate mediators of TGFbeta family signals.
- Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.
- Orphan nuclear receptor HNF-4 binds to the human coagulation factor VII promoter.
- Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas.
- Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade.
- Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.
- Prevalence and severity of fuchs corneal dystrophy in Tangier Island.
- Replication of TCF4 through association and linkage studies in late-onset Fuchs endothelial corneal dystrophy.
- Replication of the TCF4 intronic variant in late-onset Fuchs corneal dystrophy and evidence of independence from the FCD2 locus.
- Sequence specificity incompletely defines the genome-wide occupancy of Myc.
- Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes.
- Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis.
- The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism.
- Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.
- Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression.
- Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.
- Understanding pathologic variants of renal cell carcinoma: distilling therapeutic opportunities from biologic complexity.