Basic Helix-Loop-Helix Leucine Zipper Transcription Factors
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Subject Areas on Research
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A critical role for ChREBP-mediated FGF21 secretion in hepatic fructose metabolism.
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A novel ChREBP isoform in adipose tissue regulates systemic glucose metabolism.
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Activation of Nrf2 Is Required for Normal and ChREBPα-Augmented Glucose-Stimulated β-Cell Proliferation.
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Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells.
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B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.
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ChREBP regulates fructose-induced glucose production independently of insulin signaling.
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Clinical application of exome sequencing in undiagnosed genetic conditions.
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Combinatorial gene control involving E2F and E Box family members.
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Common variants conferring risk of schizophrenia.
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Control of hepatic gluconeogenesis through the transcriptional coactivator PGC-1.
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Epstein-Barr virus induces global changes in cellular mRNA isoform usage that are important for the maintenance of latency.
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Expansion of CTG18.1 Trinucleotide Repeat in TCF4 Is a Potent Driver of Fuchs' Corneal Dystrophy.
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Genetic Analysis Reveals AMPK Is Required to Support Tumor Growth in Murine Kras-Dependent Lung Cancer Models.
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Genomic regions flanking E-box binding sites influence DNA binding specificity of bHLH transcription factors through DNA shape.
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Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression.
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Identification and characterization of a highly conserved calcineurin binding protein, CBP1/calcipressin, in Cryptococcus neoformans.
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Identification of E-box factor TFE3 as a functional partner for the E2F3 transcription factor.
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Immunocytochemistry for SOX-11 and TFE3 as diagnostic markers for solid pseudopapillary neoplasms of the pancreas in FNA biopsies.
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Induction of the ChREBPβ Isoform Is Essential for Glucose-Stimulated β-Cell Proliferation.
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Intestinal apolipoprotein AI gene transcription is regulated by multiple distinct DNA elements and is synergistically activated by the orphan nuclear receptor, hepatocyte nuclear factor 4.
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Isolation of two E-box binding factors that interact with the rat tyrosine hydroxylase enhancer.
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Lactic acidosis triggers starvation response with paradoxical induction of TXNIP through MondoA.
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Lysosomal basification and decreased autophagic flux in oxidatively stressed trabecular meshwork cells: implications for glaucoma pathogenesis.
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MAP4K3 mediates amino acid-dependent regulation of autophagy via phosphorylation of TFEB.
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MTORC1 functions as a transcriptional regulator of autophagy by preventing nuclear transport of TFEB.
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Mitochondrial polymorphism A10398G and Haplogroup I are associated with Fuchs' endothelial corneal dystrophy.
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Mutations in AGBL1 cause dominant late-onset Fuchs corneal dystrophy and alter protein-protein interaction with TCF4.
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Mxi1-0, an alternatively transcribed Mxi1 isoform, is overexpressed in glioblastomas.
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Nomenclature: vertebrate mediators of TGFbeta family signals.
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Nucleus-Translocated ACSS2 Promotes Gene Transcription for Lysosomal Biogenesis and Autophagy.
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Orphan nuclear receptor HNF-4 binds to the human coagulation factor VII promoter.
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Overexpression of SOX11 and TFE3 in Solid-Pseudopapillary Neoplasms of the Pancreas.
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Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas.
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Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade.
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Polyglutamine-expanded androgen receptor interferes with TFEB to elicit autophagy defects in SBMA.
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Prevalence and severity of fuchs corneal dystrophy in Tangier Island.
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Replication of TCF4 through association and linkage studies in late-onset Fuchs endothelial corneal dystrophy.
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Replication of the TCF4 intronic variant in late-onset Fuchs corneal dystrophy and evidence of independence from the FCD2 locus.
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Sequence specificity incompletely defines the genome-wide occupancy of Myc.
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Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes.
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Sugar-sweetened beverage intake associations with fasting glucose and insulin concentrations are not modified by selected genetic variants in a ChREBP-FGF21 pathway: a meta-analysis.
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TFEB dysregulation as a driver of autophagy dysfunction in neurodegenerative disease: Molecular mechanisms, cellular processes, and emerging therapeutic opportunities.
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The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.
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The impact of the metabotropic glutamate receptor and other gene family interaction networks on autism.
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Transcription factor E2-2 is an essential and specific regulator of plasmacytoid dendritic cell development.
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Transcriptional regulation of core autophagy and lysosomal genes by the androgen receptor promotes prostate cancer progression.
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Type 2 diabetes: evidence for linkage on chromosome 20 in 716 Finnish affected sib pairs.
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Understanding pathologic variants of renal cell carcinoma: distilling therapeutic opportunities from biologic complexity.