Basic Helix-Loop-Helix Transcription Factors
-
Subject Areas on Research
-
450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy.
-
A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.
-
A gene regulatory network for root epidermis cell differentiation in Arabidopsis.
-
A genetic investigation of E2A function in lymphocyte development.
-
A mechanism for gene-environment interaction in the etiology of congenital scoliosis.
-
A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis.
-
A tamoxifen inducible knock-in allele for investigation of E2A function.
-
Acidic stress promotes a glioma stem cell phenotype.
-
Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors.
-
Adaptive mechanisms that preserve cardiac function in mice without myoglobin.
-
Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes.
-
Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities.
-
An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus.
-
Analysis of the role of E2A-encoded proteins in insulin gene transcription.
-
B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.
-
BDNF profoundly and specifically increases KCNQ4 expression in neurons derived from embryonic stem cells.
-
BayFish: Bayesian inference of transcription dynamics from population snapshots of single-molecule RNA FISH in single cells.
-
Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: metabolomics-informed genomics.
-
Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2.
-
Brassinosteroid, gibberellin and phytochrome impinge on a common transcription module in Arabidopsis.
-
Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues.
-
Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal.
-
Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis.
-
Clarifying the role of ATOH7 in glaucoma endophenotypes.
-
Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansion.
-
Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3.
-
Controlling lymphopoiesis with a combinatorial E-protein code.
-
Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3.
-
Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia.
-
Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.
-
Dependence of corneal stem/progenitor cells on ocular surface innervation.
-
Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes.
-
Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells.
-
Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice.
-
Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress.
-
Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes.
-
Drosophila Tcf and Groucho interact to repress Wingless signalling activity.
-
Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration.
-
E protein transcription factors are required for the development of CD4(+) lineage T cells.
-
E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene.
-
E proteins in lymphocyte development and lymphoid diseases.
-
E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.
-
E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells.
-
E2A promotes the survival of precursor and mature B lymphocytes.
-
Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2.
-
Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression.
-
Functional replacement of the mouse E2A gene with a human HEB cDNA.
-
Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB.
-
GTL1 and DF1 regulate root hair growth through transcriptional repression of ROOT HAIR DEFECTIVE 6-LIKE 4 in Arabidopsis.
-
Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates.
-
Genetic dissection of rod and cone pathways in the dark-adapted mouse retina.
-
Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
-
Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area.
-
Genome-wide association studies in asthma: what they really told us about pathogenesis.
-
Genomics in the neonatal nursery: Focus on ROP.
-
Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies.
-
HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development.
-
HIF1α and HIF2α exert distinct nutrient preferences in renal cells.
-
Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration.
-
Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish.
-
Hemoglobin-induced endothelial cell permeability is controlled, in part, via a myeloid differentiation primary response gene-88-dependent signaling mechanism.
-
Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.
-
Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells.
-
Id Proteins Suppress E2A-Driven Invariant Natural Killer T Cell Development prior to TCR Selection.
-
Id proteins synchronize stemness and anchorage to the niche of neural stem cells.
-
Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells.
-
Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.
-
Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system.
-
Inactivation of the von Hippel-Lindau tumor suppressor leads to selective expression of a human endogenous retrovirus in kidney cancer.
-
Inducible and conditional deletion of extracellular signal-regulated kinase 5 disrupts adult hippocampal neurogenesis.
-
Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis.
-
Intraspinal transplantation of neurogenin-expressing stem cells generates spinal cord neural progenitors.
-
Juvenile hormone regulates body size and perturbs insulin signaling in Drosophila.
-
LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo.
-
Myocardium and BMP signaling are required for endocardial differentiation.
-
NPAS1 regulates branching morphogenesis in embryonic lung.
-
NPAS3 is a trachealess homolog critical for lung development and homeostasis.
-
Negative regulation of CD4 gene expression by a HES-1-c-Myb complex.
-
Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1.
-
Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio).
-
Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.
-
New insights into E-protein function in lymphocyte development.
-
Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.
-
Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.
-
Notch signaling maintains Leydig progenitor cells in the mouse testis.
-
Orchestration of invariant natural killer T cell development by E and Id proteins.
-
Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations.
-
PIL5, a phytochrome-interacting bHLH protein, regulates gibberellin responsiveness by binding directly to the GAI and RGA promoters in Arabidopsis seeds.
-
PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.
-
Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study.
-
Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1.
-
Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade.
-
Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.
-
RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.
-
Regulation of E2A activities by histone acetyltransferases in B lymphocyte development.
-
Regulation of V(D)J recombination by E-protein transcription factors.
-
Regulation of early lymphocyte development by E2A family proteins.
-
Regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) expression in podocytes.
-
Reining in radiation injury: HIF2α in the gut.
-
Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina.
-
Sequencing analysis of the ATOH7 gene in individuals with optic nerve hypoplasia.
-
Stage-specific functions of E-proteins at the β-selection and T-cell receptor checkpoints during thymocyte development.
-
TFBSshape: a motif database for DNA shape features of transcription factor binding sites.
-
The ELF4-ELF3-LUX complex links the circadian clock to diurnal control of hypocotyl growth.
-
The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots.
-
The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon.
-
The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.
-
The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype.
-
The transcription factor HLH-2/E/Daughterless regulates anchor cell invasion across basement membrane in C. elegans.
-
Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming.
-
Transcriptional components of anteroposterior positional information during zebrafish fin regeneration.
-
Transcriptional regulation of ROS controls transition from proliferation to differentiation in the root.
-
Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.
-
Up-regulation of hypoxia-inducible factor 1 alpha and hemodynamic responses following massive small bowel resection.
-
VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.
-
c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts.
-
Keywords of People
-
Bejsovec, Amy,
Associate Professor of Biology,
Biology
-
McLendon, Roger Edwin,
Professor of Pathology,
Pathology
-
Sunday, Mary Elizabeth Anne,
Professor of Pathology,
Cell Biology
-
Velkey, John Matthew,
Assistant Professor of the Practice of Medical Education in the Department of Cell Biology,
Cell Biology