Basic Helix-Loop-Helix Transcription Factors
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Subject Areas on Research
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450K epigenome-wide scan identifies differential DNA methylation in newborns related to maternal smoking during pregnancy.
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A conserved transcriptional enhancer regulates RAG gene expression in developing B cells.
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A gene regulatory network for root epidermis cell differentiation in Arabidopsis.
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A genetic investigation of E2A function in lymphocyte development.
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A mechanism for gene-environment interaction in the etiology of congenital scoliosis.
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A new Cre driver mouse line, Tcf21/Pod1-Cre, targets metanephric mesenchyme.
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A novel role for HEB downstream or parallel to the pre-TCR signaling pathway during alpha beta thymopoiesis.
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A positive feedback loop between ROS and Mxi1-0 promotes hypoxia-induced VEGF expression in human hepatocellular carcinoma cells.
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A tamoxifen inducible knock-in allele for investigation of E2A function.
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Acidic stress promotes a glioma stem cell phenotype.
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Acquisition of a functional T cell receptor during T lymphocyte development is enforced by HEB and E2A transcription factors.
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Activity-Dependent Transcription Collaborates with Local Dendritic Translation to Encode Stimulus-Specificity in the Genome Binding of NPAS4.
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Adaptive mechanisms that preserve cardiac function in mice without myoglobin.
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Altered T-dependent antigen responses and development of autoimmune symptoms in mice lacking E2A in T lymphocytes.
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Altered Twist1 and Hand2 dimerization is associated with Saethre-Chotzen syndrome and limb abnormalities.
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An analysis of T cell intrinsic roles of E2A by conditional gene disruption in the thymus.
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Analysis of the role of E2A-encoded proteins in insulin gene transcription.
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Astrocytes follow ganglion cell axons to establish an angiogenic template during retinal development.
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B-lymphocyte development is regulated by the combined dosage of three basic helix-loop-helix genes, E2A, E2-2, and HEB.
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BDNF profoundly and specifically increases KCNQ4 expression in neurons derived from embryonic stem cells.
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BayFish: Bayesian inference of transcription dynamics from population snapshots of single-molecule RNA FISH in single cells.
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Beta-defensin 1, aryl hydrocarbon receptor and plasma kynurenine in major depressive disorder: metabolomics-informed genomics.
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Bidirectional approaches for optogenetic regulation of gene expression in mammalian cells using Arabidopsis cryptochrome 2.
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Brassinosteroid, gibberellin and phytochrome impinge on a common transcription module in Arabidopsis.
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Cell Density and Joint microRNA-133a and microRNA-696 Inhibition Enhance Differentiation and Contractile Function of Engineered Human Skeletal Muscle Tissues.
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Characterization of the neural stem cell gene regulatory network identifies OLIG2 as a multifunctional regulator of self-renewal.
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Chemokine 25-induced signaling suppresses colon cancer invasion and metastasis.
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Clarifying the role of ATOH7 in glaucoma endophenotypes.
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Combined deletion of Id2 and Id3 genes reveals multiple roles for E proteins in invariant NKT cell development and expansion.
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Concentration and desalting of protein samples for mass spectrometry analysis.
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Control of the differentiation of regulatory T cells and T(H)17 cells by the DNA-binding inhibitor Id3.
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Controlling lymphopoiesis with a combinatorial E-protein code.
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Cooperative transcriptional regulation of the essential pancreatic islet gene NeuroD1 (beta2) by Nkx2.2 and neurogenin 3.
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Correlates of Prenatal and Early-Life Tobacco Smoke Exposure and Frequency of Common Gene Deletions in Childhood Acute Lymphoblastic Leukemia.
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DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations With Cigarette Smoking and Subclinical Atherosclerosis.
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Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1.
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Dependence of corneal stem/progenitor cells on ocular surface innervation.
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Deterministic transfection drives efficient nonviral reprogramming and uncovers reprogramming barriers.
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Differential functions for the transcription factor E2A in positive and negative gene regulation in pre-B lymphocytes.
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Direct reprogramming of human fibroblasts into dopaminergic neuron-like cells.
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Discovery of Genetic Variation on Chromosome 5q22 Associated with Mortality in Heart Failure.
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Disrupted gonadogenesis and male-to-female sex reversal in Pod1 knockout mice.
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Disruption of Glucagon-Like Peptide 1 Signaling in Sim1 Neurons Reduces Physiological and Behavioral Reactivity to Acute and Chronic Stress.
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Distinct Epigenetic Effects of Tobacco Smoking in Whole Blood and among Leukocyte Subtypes.
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Distinct in vivo requirements for establishment versus maintenance of transcriptional repression.
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Drosophila Tcf and Groucho interact to repress Wingless signalling activity.
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Dynamics of the epigenetic landscape during erythroid differentiation after GATA1 restoration.
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E protein transcription factors are required for the development of CD4(+) lineage T cells.
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E proteins are required to activate germline transcription of the TCR Vbeta8.2 gene.
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E proteins in lymphocyte development and lymphoid diseases.
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E-protein-regulated expression of CXCR4 adheres preselection thymocytes to the thymic cortex.
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E2A and HEB are required to block thymocyte proliferation prior to pre-TCR expression.
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E2A and IRF-4/Pip promote chromatin modification and transcription of the immunoglobulin kappa locus in pre-B cells.
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E2A promotes the survival of precursor and mature B lymphocytes.
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Enhancer Histone Acetylation Modulates Transcriptional Bursting Dynamics of Neuronal Activity-Inducible Genes.
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Expression of MXI1, a Myc antagonist, is regulated by Sp1 and AP2.
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Expression of Neurogenin 1 in mouse embryonic stem cells directs the differentiation of neuronal precursors and identifies unique patterns of down-stream gene expression.
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Functional replacement of the mouse E2A gene with a human HEB cDNA.
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Functions of E2A-HEB heterodimers in T-cell development revealed by a dominant negative mutation of HEB.
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GTL1 and DF1 regulate root hair growth through transcriptional repression of ROOT HAIR DEFECTIVE 6-LIKE 4 in Arabidopsis.
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Generation and characterization of neurogenin1-GFP transgenic medaka with potential for rapid developmental neurotoxicity screening.
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Genetic contribution to variation in DNA methylation at maternal smoking-sensitive loci in exposed neonates.
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Genetic dissection of rod and cone pathways in the dark-adapted mouse retina.
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Genome-wide association identifies ATOH7 as a major gene determining human optic disc size.
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Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area.
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Genome-wide association studies in asthma: what they really told us about pathogenesis.
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Genomic organization of human MXI1, a putative tumor suppressor gene.
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Genomics in the neonatal nursery: Focus on ROP.
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Glutamatergic neuronal differentiation of mouse embryonic stem cells after transient expression of neurogenin 1 and treatment with BDNF and GDNF: in vitro and in vivo studies.
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HES factors regulate specific aspects of chondrogenesis and chondrocyte hypertrophy during cartilage development.
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HIF1α and HIF2α exert distinct nutrient preferences in renal cells.
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Hand2 elevates cardiomyocyte production during zebrafish heart development and regeneration.
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Hand2 regulates extracellular matrix remodeling essential for gut-looping morphogenesis in zebrafish.
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Hemoglobin-induced endothelial cell permeability is controlled, in part, via a myeloid differentiation primary response gene-88-dependent signaling mechanism.
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Hierarchical assembly and disassembly of a transcriptionally active RAG locus in CD4+CD8+ thymocytes.
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Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.
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Hypoxia inducible factor-alpha activation in lymphoma and relationship to the thioredoxin family.
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Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells.
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Id Proteins Suppress E2A-Driven Invariant Natural Killer T Cell Development prior to TCR Selection.
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Id proteins synchronize stemness and anchorage to the niche of neural stem cells.
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Id3 Restricts γδ NKT Cell Expansion by Controlling Egr2 and c-Myc Activity.
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Id3 and Id2 act as a dual safety mechanism in regulating the development and population size of innate-like γδ T cells.
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Identification of CD15 as a marker for tumor-propagating cells in a mouse model of medulloblastoma.
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Identification of E2A target genes in B lymphocyte development by using a gene tagging-based chromatin immunoprecipitation system.
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Inactivation of the von Hippel-Lindau tumor suppressor leads to selective expression of a human endogenous retrovirus in kidney cancer.
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Inducible and conditional deletion of extracellular signal-regulated kinase 5 disrupts adult hippocampal neurogenesis.
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Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis.
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Intraspinal transplantation of neurogenin-expressing stem cells generates spinal cord neural progenitors.
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Isolation of neural stem cells from the postnatal cerebellum.
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Juvenile hormone regulates body size and perturbs insulin signaling in Drosophila.
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Localization of the human Mxi1 transcription factor gene (MXI1) to chromosome 10q24-q25.
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LvGroucho and nuclear beta-catenin functionally compete for Tcf binding to influence activation of the endomesoderm gene regulatory network in the sea urchin embryo.
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MXI1, a putative tumor suppressor gene, suppresses growth of human glioblastoma cells.
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Movement and structure of mitochondria in oligodendrocytes and their myelin sheaths.
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Mxi1, a Myc antagonist, suppresses proliferation of DU145 human prostate cells.
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Mxi1-0, an alternatively transcribed Mxi1 isoform, is overexpressed in glioblastomas.
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MyoD, modularity, and myogenesis: conservation of regulators and redundancy in C. elegans.
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Myocardium and BMP signaling are required for endocardial differentiation.
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N-Myc differentially regulates expression of MXI1 isoforms in neuroblastoma.
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NCP activates chloroplast transcription by controlling phytochrome-dependent dual nuclear and plastidial switches.
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NPAS1 regulates branching morphogenesis in embryonic lung.
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NPAS3 is a trachealess homolog critical for lung development and homeostasis.
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Negative regulation of CD4 gene expression by a HES-1-c-Myb complex.
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Netrin-1-mediated axon guidance in mouse embryonic stem cells overexpressing neurogenin-1.
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Neurobehavioral effects of 1,2-propanediol in zebrafish (Danio rerio).
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Neurod6 expression defines new retinal amacrine cell subtypes and regulates their fate.
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New insights into E-protein function in lymphocyte development.
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Nonreceptor tyrosine kinase BMX maintains self-renewal and tumorigenic potential of glioblastoma stem cells by activating STAT3.
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Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies.
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Notch signaling maintains Leydig progenitor cells in the mouse testis.
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Orchestration of invariant natural killer T cell development by E and Id proteins.
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Out-foxing fate; molecular switches create neuronal diversity in the retina.
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Overexpression of NEUROG2 and NEUROG1 in human embryonic stem cells produces a network of excitatory and inhibitory neurons.
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Overexpression of the Notch target genes Hes in vivo induces lymphoid and myeloid alterations.
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PHYD prevents secondary dormancy establishment of seeds exposed to high temperature and is associated with lower PIL5 accumulation.
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PIL5, a phytochrome-interacting bHLH protein, regulates gibberellin responsiveness by binding directly to the GAI and RGA promoters in Arabidopsis seeds.
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PKA, PKC, and the protein phosphatase 2A influence HAND factor function: a mechanism for tissue-specific transcriptional regulation.
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Pan-cancer Alterations of the MYC Oncogene and Its Proximal Network across the Cancer Genome Atlas.
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Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study.
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Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study.
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Physiological notch signaling maintains bone homeostasis via RBPjk and Hey upstream of NFATc1.
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Plant hormone jasmonate prioritizes defense over growth by interfering with gibberellin signaling cascade.
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Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A.
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RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development.
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Regulation of E2A activities by histone acetyltransferases in B lymphocyte development.
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Regulation of V(D)J recombination by E-protein transcription factors.
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Regulation of early lymphocyte development by E2A family proteins.
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Regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) expression in podocytes.
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Reining in radiation injury: HIF2α in the gut.
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Relative contributions of rod and cone bipolar cell inputs to AII amacrine cell light responses in the mouse retina.
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SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.
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Sequencing analysis of the ATOH7 gene in individuals with optic nerve hypoplasia.
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Somatostatin receptor 2 signaling promotes growth and tumor survival in small-cell lung cancer.
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Sonic hedgehog pathway activation is induced by acute brain injury and regulated by injury-related inflammation.
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Stage-specific functions of E-proteins at the β-selection and T-cell receptor checkpoints during thymocyte development.
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TFBSshape: a motif database for DNA shape features of transcription factor binding sites.
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The ELF4-ELF3-LUX complex links the circadian clock to diurnal control of hypocotyl growth.
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The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality.
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The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots.
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The circadian regulatory proteins BMAL1 and cryptochromes are substrates of casein kinase Iepsilon.
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The forkhead genes, Foxc1 and Foxc2, regulate paraxial versus intermediate mesoderm cell fate.
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The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype.
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The transcription factor HLH-2/E/Daughterless regulates anchor cell invasion across basement membrane in C. elegans.
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Transcription Factor 21 Is Required for Branching Morphogenesis and Regulates the Gdnf-Axis in Kidney Development.
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Transcription factors MYOCD, SRF, Mesp1 and SMARCD3 enhance the cardio-inducing effect of GATA4, TBX5, and MEF2C during direct cellular reprogramming.
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Transcriptional components of anteroposterior positional information during zebrafish fin regeneration.
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Transcriptional regulation of ROS controls transition from proliferation to differentiation in the root.
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Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.
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Two distinct class A helix-loop-helix transcription factors, E2A and BETA1, form separate DNA binding complexes on the insulin gene E box.
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Up-regulation of hypoxia-inducible factor 1 alpha and hemodynamic responses following massive small bowel resection.
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VHL Deficiency Drives Enhancer Activation of Oncogenes in Clear Cell Renal Cell Carcinoma.
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c-Myc creates an activation loop by transcriptionally repressing its own functional inhibitor, hMad4, in young fibroblasts, a loop lost in replicatively senescent fibroblasts.
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Keywords of People
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Bejsovec, Amy,
Associate Professor of Biology,
Biology
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McLendon, Roger Edwin,
Professor of Pathology,
Pathology
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Sunday, Mary Elizabeth Anne,
Professor of Pathology,
Cell Biology
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Velkey, John Matthew,
Assistant Professor of the Practice of Medical Education in the Department of Cell Biology,
Cell Biology