Hypoxia-Inducible Factor 1

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  Subject Areas on Research

  • A hot spot for hydrogen peroxide-induced damage in the human hypoxia-inducible factor 1 binding site of the PGK 1 gene. 
  • A molecular mechanism for the differential regulation of TGF-beta1 expression due to the common SNP -509C-T (c. -1347C > T). 
  • A robust automated measure of average antibody staining in immunohistochemistry images. 
  • Acute oxygen-sensing mechanisms. 
  • Adaptive mechanisms that preserve cardiac function in mice without myoglobin. 
  • Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations. 
  • Collapsing glomerulopathy: an inflammatory podocytopathy? 
  • Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response. 
  • Early fetal hypoxia leads to growth restriction and myocardial thinning. 
  • Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia. 
  • Effects of high-dose microbeam irradiation on tumor microvascular function and angiogenesis. 
  • Endogenous S-nitrosothiols protect against myocardial injury. 
  • Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis. 
  • Evolving revascularization approaches for myocardial ischemia. 
  • Exploiting metabolic differences in glioma therapy. 
  • Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy. 
  • Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women. 
  • HIF-1 and tumour radiosensitivity. 
  • HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia. 
  • High oxygen prevents fetal lethality due to lack of catecholamines. 
  • Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation. 
  • Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia. 
  • Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene. 
  • Implications of hypoxia on mucosal barrier function. 
  • Improving the quantitative accuracy of optical-emission computed tomography by incorporating an attenuation correction: application to HIF1 imaging. 
  • In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy. 
  • Inflammatory hypoxia: role of hypoxia-inducible factor. 
  • Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting. 
  • Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression. 
  • Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition. 
  • NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment. 
  • Nucleophilic addition of organozinc reagents to 2-sulfonyl cyclic ethers: stereoselective synthesis of manassantins A and B. 
  • Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation. 
  • Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition. 
  • Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity. 
  • Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules. 
  • Raising the bar: how HIF-1 helps determine tumor radiosensitivity. 
  • Single cell transcriptome analysis of mouse carotid body glomus cells. 
  • Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis. 
  • The effect of irrigation solution at different temperatures on articular cartilage metabolism. 
  • The potential role of intrinsic hypoxia markers as prognostic variables in cancer. 
  • Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation. 
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  Keywords of People

  • Karhausen, Jorn, Adjunct Associate Professor in the Department of Anesthesiology, Anesthesiology, Cardiothoracic
  • Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering
  • Yan, Hai, Adjunct Professor of Pathology, Pathology