Hypoxia-Inducible Factor 1
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Subject Areas on Research
- A hot spot for hydrogen peroxide-induced damage in the human hypoxia-inducible factor 1 binding site of the PGK 1 gene.
- A molecular mechanism for the differential regulation of TGF-beta1 expression due to the common SNP -509C-T (c. -1347C > T).
- A robust automated measure of average antibody staining in immunohistochemistry images.
- Acute oxygen-sensing mechanisms.
- Adaptive mechanisms that preserve cardiac function in mice without myoglobin.
- Analysis of HIF-1 inhibition by manassantin A and analogues with modified tetrahydrofuran configurations.
- Collapsing glomerulopathy: an inflammatory podocytopathy?
- Cycling hypoxia and free radicals regulate angiogenesis and radiotherapy response.
- Early fetal hypoxia leads to growth restriction and myocardial thinning.
- Ecto-5'-nucleotidase (CD73) regulation by hypoxia-inducible factor-1 mediates permeability changes in intestinal epithelia.
- Effects of high-dose microbeam irradiation on tumor microvascular function and angiogenesis.
- Endogenous S-nitrosothiols protect against myocardial injury.
- Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis.
- Evolving revascularization approaches for myocardial ischemia.
- Exploiting metabolic differences in glioma therapy.
- Exploring the role of HIF-1 in early angiogenesis and response to radiotherapy.
- Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women.
- HIF-1 and tumour radiosensitivity.
- HIF-1-dependent repression of equilibrative nucleoside transporter (ENT) in hypoxia.
- High oxygen prevents fetal lethality due to lack of catecholamines.
- Hypoxia decreases creatine uptake in cardiomyocytes, while creatine supplementation enhances HIF activation.
- Hypoxia-inducible factor-1 mediates transcriptional activation of the heme oxygenase-1 gene in response to hypoxia.
- Hypoxia-inducible factor-1-dependent regulation of the multidrug resistance (MDR1) gene.
- Implications of hypoxia on mucosal barrier function.
- Improving the quantitative accuracy of optical-emission computed tomography by incorporating an attenuation correction: application to HIF1 imaging.
- In vivo bioluminescence imaging monitoring of hypoxia-inducible factor 1alpha, a promoter that protects cells, in response to chemotherapy.
- Inflammatory hypoxia: role of hypoxia-inducible factor.
- Intermittent hypoxia furthers the rationale for hypoxia-inducible factor-1 targeting.
- Leukocyte adhesion during hypoxia is mediated by HIF-1-dependent induction of beta2 integrin gene expression.
- Mucosal protection by hypoxia-inducible factor prolyl hydroxylase inhibition.
- NADPH oxidase-mediated reactive oxygen species production activates hypoxia-inducible factor-1 (HIF-1) via the ERK pathway after hyperthermia treatment.
- Nucleophilic addition of organozinc reagents to 2-sulfonyl cyclic ethers: stereoselective synthesis of manassantins A and B.
- Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation.
- Physiologic hypoxia promotes maintenance of CML stem cells despite effective BCR-ABL1 inhibition.
- Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.
- Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules.
- Raising the bar: how HIF-1 helps determine tumor radiosensitivity.
- Single cell transcriptome analysis of mouse carotid body glomus cells.
- Targeting the lactate transporter MCT1 in endothelial cells inhibits lactate-induced HIF-1 activation and tumor angiogenesis.
- The effect of irrigation solution at different temperatures on articular cartilage metabolism.
- The potential role of intrinsic hypoxia markers as prognostic variables in cancer.
- Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation.
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Keywords of People
- Karhausen, Jorn, Adjunct Associate Professor in the Department of Anesthesiology, Anesthesiology, Cardiothoracic
- Turner, Dennis Alan, Professor of Neurosurgery, Biomedical Engineering
- Yan, Hai, Adjunct Professor of Pathology, Pathology