Hypoxia-Inducible Factor 1, alpha Subunit
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Subject Areas on Research
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A hot spot for hydrogen peroxide-induced damage in the human hypoxia-inducible factor 1 binding site of the PGK 1 gene.
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ABL kinases regulate the stabilization of HIF-1α and MYC through CPSF1.
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Aberrant activation of signal transducer and activator of transcription-3 (STAT3) signaling in endometriosis.
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Acidic stress promotes a glioma stem cell phenotype.
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Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism.
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Adaptive mechanisms that preserve cardiac function in mice without myoglobin.
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An unexpected alliance between stress responses to drive oncogenesis.
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Analysis of tumor environmental response and oncogenic pathway activation identifies distinct basal and luminal features in HER2-related breast tumor subtypes.
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Antiangiogenic therapy for primary liver cancer: correlation of changes in dynamic contrast-enhanced magnetic resonance imaging with tissue hypoxia markers and clinical response.
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Carbohydrate restriction and lactate transporter inhibition in a mouse xenograft model of human prostate cancer.
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Conditional HIF-1 induction produces multistage neovascularization with stage-specific sensitivity to VEGFR inhibitors and myeloid cell independence.
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Declining NAD(+) induces a pseudohypoxic state disrupting nuclear-mitochondrial communication during aging.
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EGFR in enterocytes & endothelium and HIF1α in enterocytes are dispensable for massive small bowel resection induced angiogenesis.
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Enhanced HIF2α expression during human trophoblast differentiation into syncytiotrophoblast suppresses transcription of placental growth factor.
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Enhancement of hypoxia-induced tumor cell death in vitro and radiation therapy in vivo by use of small interfering RNA targeted to hypoxia-inducible factor-1alpha.
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Evolving revascularization approaches for myocardial ischemia.
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Expression of HIF-1alpha, CA IX, VEGF, and MMP-9 in surgically resected non-small cell lung cancer.
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Extra-placental expression of vascular endothelial growth factor receptor-1, (Flt-1) and soluble Flt-1 (sFlt-1), by peripheral blood mononuclear cells (PBMCs) in normotensive and preeclamptic pregnant women.
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FIH-1-modulated HIF-1α C-TAD promotes acute kidney injury to chronic kidney disease progression via regulating KLF5 signaling.
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Frequency and phenotypic implications of mitochondrial DNA mutations in human squamous cell cancers of the head and neck.
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Functional interaction between responses to lactic acidosis and hypoxia regulates genomic transcriptional outputs.
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Gene expression programs in response to hypoxia: cell type specificity and prognostic significance in human cancers.
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HIF-1 Alpha Regulates the Response of Primary Sarcomas to Radiation Therapy through a Cell Autonomous Mechanism.
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HIF-1alpha induces genetic instability by transcriptionally downregulating MutSalpha expression.
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HIF-1α in heart: protective mechanisms.
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HIF-1α inducing exosomal microRNA-23a expression mediates the cross-talk between tubular epithelial cells and macrophages in tubulointerstitial inflammation.
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HIF-miR-215-KDM1B promotes glioma-initiating cell adaptation to hypoxia.
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HIF1α and HIF2α exert distinct nutrient preferences in renal cells.
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Hedgehog controls hepatic stellate cell fate by regulating metabolism.
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Hif-1a suppresses ROS-induced proliferation of cardiac fibroblasts following myocardial infarction.
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Hyperactivated JNK is a therapeutic target in pVHL-deficient renal cell carcinoma.
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Hypoxia Signaling Cascade for Erythropoietin Production in Hepatocytes.
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Hypoxia inducible factor-1 alpha activation of the JCV promoter: role in the pathogenesis of progressive multifocal leukoencephalopathy.
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Hypoxia inhibits induction of aryl hydrocarbon receptor activity in topminnow hepatocarcinoma cells in an ARNT-dependent manner.
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Hypoxia-inducible factor-1α plays roles in Epstein-Barr virus's natural life cycle and tumorigenesis by inducing lytic infection through direct binding to the immediate-early BZLF1 gene promoter.
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Hypoxia-inducible factors regulate tumorigenic capacity of glioma stem cells.
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Imaging molecular pathways: reporter genes.
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Immunohistochemical characterization of Renaut bodies in superficial digital nerves: further evidence supporting their perineurial cell origin.
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In regard to Arvold et al. (Int J Radiat Oncol Biol Phys 2005;62:207-212).
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Indirect Tumor Cell Death After High-Dose Hypofractionated Irradiation: Implications for Stereotactic Body Radiation Therapy and Stereotactic Radiation Surgery.
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Induction of angiogenic immediate early genes by activation of FP prostanoid receptors in cultured human ciliary smooth muscle cells.
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Inflammation and functional iron deficiency regulate fibroblast growth factor 23 production.
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Left-Biased Spermatogenic Failure in 129/SvJ Dnd1Ter/+ Mice Correlates with Differences in Vascular Architecture, Oxygen Availability, and Metabolites.
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Leptin directly promotes T-cell glycolytic metabolism to drive effector T-cell differentiation in a mouse model of autoimmunity.
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Loss of Endothelial Hypoxia Inducible Factor-Prolyl Hydroxylase 2 Induces Cardiac Hypertrophy and Fibrosis.
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Metabolic reprogramming is required for antibody production that is suppressed in anergic but exaggerated in chronically BAFF-exposed B cells.
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Mitophagy defects arising from BNip3 loss promote mammary tumor progression to metastasis.
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Natural and inducible TH17 cells are regulated differently by Akt and mTOR pathways.
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Nonclassical Monocytes Sense Hypoxia, Regulate Pulmonary Vascular Remodeling, and Promote Pulmonary Hypertension.
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Observation of incipient tumor angiogenesis that is independent of hypoxia and hypoxia inducible factor-1 activation.
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Oncogene pathway activation in mammary tumors dictates FDG-PET uptake.
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Overexpression of Four Joint Box-1 Protein (FJX1) in Eutopic Endometrium From Women With Endometriosis.
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Oxygen-regulated beta(2)-adrenergic receptor hydroxylation by EGLN3 and ubiquitylation by pVHL.
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PTEN status mediates 2ME2 anti-tumor efficacy in preclinical glioblastoma models: role of HIF1α suppression.
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Pleiotropic effects of HIF-1 blockade on tumor radiosensitivity.
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Protein kinase C zeta transactivates hypoxia-inducible factor alpha by promoting its association with p300 in renal cancer.
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Quantitative analysis of biomarkers defines an optimal biological dose for recombinant human endostatin in primary human tumors.
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RNA interference targeting hypoxia inducible factor 1α reduces post-operative adhesions in rats
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ROS production and angiogenic regulation by macrophages in response to heat therapy.
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Radiation activates HIF-1 to regulate vascular radiosensitivity in tumors: role of reoxygenation, free radicals, and stress granules.
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Radiation and a metalloporphyrin radioprotectant in a mouse prostate tumor model.
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Reactivation of Epstein-Barr Virus by HIF-1α Requires p53.
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Regional effects of an antivascular endothelial growth factor receptor monoclonal antibody on receptor phosphorylation and apoptosis in human 253J B-V bladder cancer xenografts.
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Regulation of HIF-1alpha stability through S-nitrosylation.
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Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2.
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Regulation of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF-A) expression in podocytes.
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Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress.
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S-nitrosylation in the regulation of gene transcription.
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SPHK1 Is a Novel Target of Metformin in Ovarian Cancer.
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Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia.
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Synthesis and Biological Evaluation of Manassantin Analogues for Hypoxia-Inducible Factor 1α Inhibition.
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Targeting Hypoxia-Inducible Factor 1α in a New Orthotopic Model of Glioblastoma Recapitulating the Hypoxic Tumor Microenvironment.
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The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling.
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The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer.
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The hypoxic microenvironment maintains glioblastoma stem cells and promotes reprogramming towards a cancer stem cell phenotype.
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Thermal dose fractionation affects tumour physiological response.
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Topotecan is a potent inhibitor of SUMOylation in glioblastoma multiforme and alters both cellular replication and metabolic programming.
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Tumor cells upregulate normoxic HIF-1α in response to doxorubicin.
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Tumor vasculature is regulated by PHD2-mediated angiogenesis and bone marrow-derived cell recruitment.
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Up-regulation of hypoxia-inducible factor 1 alpha and hemodynamic responses following massive small bowel resection.
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VEGF is essential for hypoxia-inducible factor-mediated neovascularization but dispensable for endothelial sprouting.
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β-arrestin1 mediates metastatic growth of breast cancer cells by facilitating HIF-1-dependent VEGF expression.
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