alpha-Synuclein

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  Subject Areas on Research

  • A cytosine-thymine (CT)-rich haplotype in intron 4 of SNCA confers risk for Lewy body pathology in Alzheimer's disease and affects SNCA expression. 
  • Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats. 
  • Alpha-synuclein lesions in normal aging, Parkinson disease, and Alzheimer disease: evidence from the Baltimore Longitudinal Study of Aging (BLSA). 
  • Alpha-synuclein: Pathology, mitochondrial dysfunction and neuroinflammation in Parkinson's disease. 
  • Analysis of Brain Protein Stability Changes in Mouse Models of Normal Aging and α-Synucleinopathy Reveals Age- and Disease-Related Differences. 
  • Breathing new life into an old target: pulmonary disease drugs for Parkinson's disease therapy. 
  • Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling. 
  • Dopamine and α-synuclein dysfunction in Smad3 null mice. 
  • Downregulation of SNCA Expression by Targeted Editing of DNA Methylation: A Potential Strategy for Precision Therapy in PD. 
  • Effect of allelic variation at the NACP-Rep1 repeat upstream of the alpha-synuclein gene (SNCA) on transcription in a cell culture luciferase reporter system. 
  • Expansion of the Parkinson disease-associated SNCA-Rep1 allele upregulates human alpha-synuclein in transgenic mouse brain. 
  • Extensive uptake of α-synuclein oligomers in astrocytes results in sustained intracellular deposits and mitochondrial damage. 
  • Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes. 
  • Functional analysis of intra-allelic variation at NACP-Rep1 in the alpha-synuclein gene. 
  • G2019S-LRRK2 Expression Augments α-Synuclein Sequestration into Inclusions in Neurons. 
  • Genetic analysis of α-synuclein 3' untranslated region and its corresponding microRNAs in relation to Parkinson's disease compared to dementia with Lewy bodies. 
  • Genetic and Environmental Factors in Parkinson's Disease Converge on Immune Function and Inflammation. 
  • Genetic regulation of alpha-synuclein mRNA expression in various human brain tissues. 
  • Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease. 
  • Heterogeneity in α-synuclein fibril activity correlates to disease phenotypes in Lewy body dementia. 
  • Human and mouse alpha-synuclein genes: comparative genomic sequence analysis and identification of a novel gene regulatory element. 
  • Identification of Novel α-Synuclein Assemblies in Lewy Body Disease. 
  • Inhibition of LRRK2 kinase activity promotes anterograde axonal transport and presynaptic targeting of α-synuclein. 
  • LRRK2 activation in idiopathic Parkinson's disease. 
  • Leucine-rich Repeat Kinase 2 (LRRK2) Pharmacological Inhibition Abates α-Synuclein Gene-induced Neurodegeneration. 
  • Levels of alpha-synuclein mRNA in sporadic Parkinson disease patients. 
  • Lewy body pathology is a frequent co-pathology in familial Alzheimer's disease. 
  • Molecular Features Underlying Neurodegeneration Identified through In Vitro Modeling of Genetically Diverse Parkinson's Disease Patients. 
  • Multiplication of the SNCA locus exacerbates neuronal nuclear aging. 
  • Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. 
  • Nitrated alpha-synuclein immunity accelerates degeneration of nigral dopaminergic neurons. 
  • PGC-1α, a potential therapeutic target for early intervention in Parkinson's disease. 
  • Parkinson's disease from the gut. 
  • Pathological α-synuclein recruits LRRK2 expressing pro-inflammatory monocytes to the brain. 
  • Phosphorylation of an alpha-synuclein peptide fragment enhances metal binding. 
  • Phosphorylation-dependent metal binding by alpha-synuclein peptide fragments. 
  • Regulation of alpha-synuclein expression by poly (ADP ribose) polymerase-1 (PARP-1) binding to the NACP-Rep1 polymorphic site upstream of the SNCA gene. 
  • Regulation of alpha-synuclein expression: implications for Parkinson's disease. 
  • Regulatory T cells attenuate Th17 cell-mediated nigrostriatal dopaminergic neurodegeneration in a model of Parkinson's disease. 
  • Revelations and revolutions in the understanding of Parkinson's disease. 
  • Sensitivity and specificity of phospho-Ser129 α-synuclein monoclonal antibodies. 
  • Structural variants in SNCA gene and the implication to synucleinopathies. 
  • Synergistic Interactions between Abeta, tau, and alpha-synuclein: acceleration of neuropathology and cognitive decline. 
  • Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production. 
  • Tau induces formation of α-synuclein filaments with distinct molecular conformations. 
  • The alpha-synuclein gene is not a major risk factor in familial Parkinson disease. 
  • The effect of SNCA 3' region on the levels of SNCA-112 splicing variant. 
  • The genetic contributions of SNCA and LRRK2 genes to Lewy Body pathology in Alzheimer's disease. 
  • The interplay between monocytes, α-synuclein and LRRK2 in Parkinson's disease. 
  • The mechanistic role of alpha-synuclein in the nucleus: impaired nuclear function caused by familial Parkinson's disease SNCA mutations. 
  • The role of alpha-synuclein in Parkinson's disease: insights from animal models. 
  • The therapeutic potential of LRRK2 and alpha-synuclein in Parkinson's disease. 
  • The unlikely partnership between LRRK2 and α-synuclein in Parkinson's disease. 
  • Toward deciphering the mechanistic role of variations in the Rep1 repeat site in the transcription regulation of SNCA gene. 
  • Untwisted α-Synuclein Filaments Formed in the Presence of Lipid Vesicles. 
  • Up-regulation of SNCA gene expression: implications to synucleinopathies. 
  • Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein. 
  • alpha-Synuclein gene haplotypes are associated with Parkinson's disease. 
  • α-Synuclein fibril-induced inclusion spread in rats and mice correlates with dopaminergic Neurodegeneration. 
  • α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration. 
  • α-synucleinopathy exerts sex-dimorphic effects on the multipurpose DNA repair/redox protein APE1 in mice and humans.