Fanconi Anemia Complementation Group Proteins
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Subject Areas on Research
- A variant at a potentially functional microRNA-binding site in BRIP1 was associated with risk of squamous cell carcinoma of the head and neck.
- A viral microRNA functions as an orthologue of cellular miR-155.
- Absence of truncating BRIP1 mutations in chromosome 17q-linked hereditary prostate cancer families.
- FANCD2 monoubiquitination and activation by hexavalent chromium [Cr(VI)] exposure: activation is not required for repair of Cr(VI)-induced DSBs.
- Fanconi Anemia FANCM/FNCM-1 and FANCD2/FCD-2 Are Required for Maintaining Histone Methylation Levels and Interact with the Histone Demethylase LSD1/SPR-5 in Caenorhabditis elegans .
- Fanconi anemia gene variants in therapy-related myeloid neoplasms.
- Germline genetic variants in men with prostate cancer and one or more additional cancers.
- High incidence of female reproductive tract cancers in FA-deficient HPV16-transgenic mice correlates with E7's induction of DNA damage response, an activity mediated by E7's inactivation of pocket proteins.
- Inactivation of the tumor suppressor genes causing the hereditary syndromes predisposing to head and neck cancer via promoter hypermethylation in sporadic head and neck cancers.
- Rare germline mutations in African American men diagnosed with early-onset prostate cancer.
- Rare loss of function variants in candidate genes and risk of colorectal cancer.
- The genome's best friend.
- Ubiquitin recognition by FAAP20 expands the complex interface beyond the canonical UBZ domain.