Receptors, Notch

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  Subject Areas on Research

  • A Fringe-modified Notch signal affects specification of mesoderm and endoderm in the sea urchin embryo. 
  • A Novel Notch-YAP Circuit Drives Stemness and Tumorigenesis in Embryonal Rhabdomyosarcoma. 
  • A collection of cortical crescents: asymmetric protein localization in CNS precursor cells. 
  • A mechanism for gene-environment interaction in the etiology of congenital scoliosis. 
  • A method to culture human alveolar rhabdomyosarcoma cell lines as rhabdospheres demonstrates an enrichment in stemness and Notch signaling. 
  • A micromere induction signal is activated by beta-catenin and acts through notch to initiate specification of secondary mesenchyme cells in the sea urchin embryo. 
  • A survival guide to early T cell development. 
  • ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds. 
  • AMPK Is Essential to Balance Glycolysis and Mitochondrial Metabolism to Control T-ALL Cell Stress and Survival. 
  • Abnormal vertebral segmentation and the notch signaling pathway in man. 
  • Acquisition of epithelial-mesenchymal transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of the notch signaling pathway. 
  • Adaptive Chromatin Remodeling Drives Glioblastoma Stem Cell Plasticity and Drug Tolerance. 
  • Airway-specific inducible transgene expression using aerosolized doxycycline. 
  • Biology of cerebral arteriovenous malformations with a focus on inflammation. 
  • CCR2 deficiency, dysregulation of Notch signaling, and spontaneous pulmonary arterial hypertension. 
  • Cartilage-specific RBPjκ-dependent and -independent Notch signals regulate cartilage and bone development. 
  • Ccm1 is required for arterial morphogenesis: implications for the etiology of human cavernous malformations. 
  • Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration. 
  • Coactivation of NF-κB and Notch signaling is sufficient to induce B-cell transformation and enables B-myeloid conversion. 
  • Connectomics of the zebrafish's lateral-line neuromast reveals wiring and miswiring in a simple microcircuit. 
  • Cross-species DNA copy number analyses identifies multiple 1q21-q23 subtype-specific driver genes for breast cancer. 
  • Cross-talk between Notch and Hedgehog regulates hepatic stellate cell fate in mice. 
  • Cutaneous wound healing: recruiting developmental pathways for regeneration. 
  • Delta-like 1-Lysine613 regulates notch signaling. 
  • Developmental regulation of apical endocytosis controls epithelial patterning in vertebrate tubular organs. 
  • Divergent Roles of Epithelium-Derived Alarmins in Notch Signaling-Deficient Skin. 
  • Dynamics of Delta/Notch signaling on endomesoderm segregation in the sea urchin embryo. 
  • Endothelial deletion of murine Jag1 leads to valve calcification and congenital heart defects associated with Alagille syndrome. 
  • Error-prone polyploid mitosis during normal Drosophila development. 
  • Ex Vivo Expansion or Manipulation of Stem Cells to Improve Outcome of Umbilical Cord Blood Transplantation. 
  • Frizzled5/8 is required in secondary mesenchyme cells to initiate archenteron invagination during sea urchin development. 
  • From the yolk sac to the spleen: New roles for Notch in regulating hematopoiesis. 
  • Functional diversity of notch family genes in fetal lung development. 
  • GFAP is necessary for the integrity of CNS white matter architecture and long-term maintenance of myelination. 
  • Gene deletion screen for cardiomyopathy in adult Drosophila identifies a new notch ligand. 
  • Genetic variants of genes in the Notch signaling pathway predict overall survival of non-small cell lung cancer patients in the PLCO study. 
  • Genomics and expression profiles of the Hedgehog and Notch signaling pathways in sea urchin development. 
  • Hedgehog and Notch signaling regulate self-renewal of undifferentiated pleomorphic sarcomas. 
  • Hepatocyte Notch activation induces liver fibrosis in nonalcoholic steatohepatitis. 
  • Heterochrony in somitogenesis rate in a model marsupial, Monodelphis domestica. 
  • Identification and localization of a sea urchin Notch homologue: insights into vegetal plate regionalization and Notch receptor regulation. 
  • Identification of neural transcription factors required for the differentiation of three neuronal subtypes in the sea urchin embryo. 
  • Improving the outcome of umbilical cord blood transplantation through ex vivo expansion or graft manipulation. 
  • Inhibition of notch signaling induces neural differentiation in Ewing sarcoma. 
  • Inhibition of the Notch-Hey1 axis blocks embryonal rhabdomyosarcoma tumorigenesis. 
  • Initial testing (stage 1) by the pediatric preclinical testing program of RO4929097, a γ-secretase inhibitor targeting notch signaling. 
  • Initial testing (stage 1) of the notch inhibitor PF-03084014, by the pediatric preclinical testing program. 
  • Intriguing Roles for Endothelial ADAM10/Notch Signaling in the Development of Organ-Specific Vascular Beds. 
  • Investigation of Notch3 as a candidate gene for bipolar disorder using brain hyperintensities as an endophenotype. 
  • LvNotch signaling mediates secondary mesenchyme specification in the sea urchin embryo. 
  • LvNotch signaling plays a dual role in regulating the position of the ectoderm-endoderm boundary in the sea urchin embryo. 
  • LvNumb works synergistically with Notch signaling to specify non-skeletal mesoderm cells in the sea urchin embryo. 
  • Lymphocyte selection by starvation: glucose metabolism and cell death. 
  • MYC Drives Temporal Evolution of Small Cell Lung Cancer Subtypes by Reprogramming Neuroendocrine Fate. 
  • Maintenance of T cell specification and differentiation requires recurrent notch receptor-ligand interactions. 
  • Marked induction of the helix-loop-helix protein Id3 promotes the gammadelta T cell fate and renders their functional maturation Notch independent. 
  • Molecular pathways: translational and therapeutic implications of the Notch signaling pathway in cancer. 
  • Mutational landscapes of tongue carcinoma reveal recurrent mutations in genes of therapeutic and prognostic relevance. 
  • NOTCH signaling in skeletal progenitors is critical for fracture repair. 
  • NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. 
  • Neighborhood watch orchestrates liver regeneration. 
  • Notch signaling genes: myogenic DNA hypomethylation and 5-hydroxymethylcytosine. 
  • Notch signaling in cancer stem cells. 
  • Notch signaling in postnatal joint chondrocytes, but not subchondral osteoblasts, is required for articular cartilage and joint maintenance. 
  • Notch signaling indirectly promotes chondrocyte hypertrophy via regulation of BMP signaling and cell cycle arrest. 
  • Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies. 
  • Notch signaling maintains Leydig progenitor cells in the mouse testis. 
  • Notch signaling maintains bone marrow mesenchymal progenitors by suppressing osteoblast differentiation. 
  • Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice. 
  • Notch signaling: a common pathway of injury in podocytopathies? 
  • Notch signalling in B cells. 
  • Notch-Induced Myeloid Reprogramming in Spontaneous Pancreatic Ductal Adenocarcinoma by Dual Genetic Targeting. 
  • Notch-dependent differentiation of adult airway basal stem cells. 
  • Notch/Delta expression in the developing mouse lung. 
  • Notch3 pathway alterations in ovarian cancer. 
  • Numb antagonizes Notch signaling to specify sibling neuron cell fates. 
  • Numb regulates somatic cell lineage commitment during early gonadogenesis in mice. 
  • Obligatory role for cooperative signaling by pre-TCR and Notch during thymocyte differentiation. 
  • Partial co-option of the appendage patterning pathway in the development of abdominal appendages in the sepsid fly Themira biloba. 
  • Phospholipid membrane composition affects EGF receptor and Notch signaling through effects on endocytosis during Drosophila development. 
  • Pleiotrophin regulates the expansion and regeneration of hematopoietic stem cells. 
  • Potentially functional genetic variants of the notch signaling pathway genes predict survival of Chinese patients with esophageal squamous cell carcinoma. 
  • RBP-Jκ-dependent Notch signaling is required for murine articular cartilage and joint maintenance. 
  • RBPjkappa-dependent Notch signaling regulates mesenchymal progenitor cell proliferation and differentiation during skeletal development. 
  • Recent Insights into Notch Signaling in Embryonal Rhabdomyosarcoma. 
  • Receptor regulation: beta-arrestin moves up a notch. 
  • Regulation of glioblastoma stem cells by retinoic acid: role for Notch pathway inhibition. 
  • Repression of Sox9 by Jag1 is continuously required to suppress the default chondrogenic fate of vascular smooth muscle cells. 
  • Specification of endoderm and mesoderm in the sea urchin. 
  • Spine Patterning Is Guided by Segmentation of the Notochord Sheath. 
  • Stage-specific and differential notch dependency at the alphabeta and gammadelta T lineage bifurcation. 
  • Stem cells and their niches: integrated units that maintain Drosophila tissues. 
  • Temporal modulation of collective cell behavior controls vascular network topology. 
  • Testosterone levels influence mouse fetal Leydig cell progenitors through notch signaling. 
  • The cell of origin and subtype of K-Ras-induced lung tumors are modified by Notch and Sox2. 
  • The murine winged helix transcription factors, Foxc1 and Foxc2, are both required for cardiovascular development and somitogenesis. 
  • The thymus as an inductive site for T lymphopoiesis. 
  • Toward understanding cancer stem cell heterogeneity in the tumor microenvironment. 
  • Transient gamma-secretase inhibition accelerates and enhances fracture repair likely via Notch signaling modulation. 
  • Updating the Wnt pathways. 
  • Upregulated claudin-1 expression promotes colitis-associated cancer by promoting β-catenin phosphorylation and activation in Notch/p-AKT-dependent manner. 
  • Use of Hes1-GFP reporter mice to assess activity of the Hes1 promoter in bone cells under chronic inflammation. 
  • Variants in Notch signalling pathway genes, PSEN1 and MAML2, predict overall survival in Chinese patients with epithelial ovarian cancer. 
  • miR-203, a tumor suppressor frequently down-regulated by promoter hypermethylation in rhabdomyosarcoma. 
  • miR-33a promotes glioma-initiating cell self-renewal via PKA and NOTCH pathways. 
  • neurotic, a novel maternal neurogenic gene, encodes an O-fucosyltransferase that is essential for Notch-Delta interactions. 
  • siRNA inhibition of aspartyl-asparaginyl β-hydroxylase expression impairs cell motility, Notch signaling, and fetal growth. 
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  Keywords of People

  • Choi, Steven Sok, Associate Professor of Medicine, Medicine, Gastroenterology
  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology
  • Hogan, Brigid L. M., Research Professor of Cell Biology, Cell Biology