Receptor, Notch1

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  Subject Areas on Research

  • ADAM10 is essential for proteolytic activation of Notch during thymocyte development. 
  • ADAM10-Dependent Signaling Through Notch1 and Notch4 Controls Development of Organ-Specific Vascular Beds. 
  • Activation of Notch1 synergizes with multiple pathways in promoting castration-resistant prostate cancer. 
  • Adam10 is essential for early embryonic cardiovascular development. 
  • Analysis of the Conditions That Affect the Selective Processing of Endogenous Notch1 by ADAM10 and ADAM17. 
  • Cell type-specific effects of Notch signaling activation on intervertebral discs: Implications for intervertebral disc degeneration. 
  • Constitutive Notch signalling promotes CD4 CD8 thymocyte differentiation in the absence of the pre-TCR complex, by mimicking pre-TCR signals. 
  • Constitutive activation of NOTCH1 signaling in Sertoli cells causes gonocyte exit from quiescence. 
  • Correlating notch signaling with thymocyte maturation. 
  • Decreased Notch pathway signaling in the endometrium of women with endometriosis impairs decidualization. 
  • Deltex1 redirects lymphoid progenitors to the B cell lineage by antagonizing Notch1. 
  • Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. 
  • Down-regulation of platelet-derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and nuclear factor-kappaB signaling. 
  • Epidermal growth factor receptor-related protein inhibits cell growth and invasion in pancreatic cancer. 
  • Epithelial NOTCH Signaling Rewires the Tumor Microenvironment of Colorectal Cancer to Drive Poor-Prognosis Subtypes and Metastasis. 
  • Expression of EGFR, VEGF, and NOTCH1 suggest differences in tumor angiogenesis in HPV-positive and HPV-negative head and neck squamous cell carcinoma. 
  • Functional analysis of the TAN-1 gene, a human homolog of Drosophila notch. 
  • Hypercholesterolemia induces oxidant stress that accelerates the ageing of hematopoietic stem cells. 
  • Identification of molecular signature of head and neck cancer stem-like cells. 
  • Macrophages Promote Aortic Valve Cell Calcification and Alter STAT3 Splicing. 
  • Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. 
  • NOTCH1 regulates osteoclastogenesis directly in osteoclast precursors and indirectly via osteoblast lineage cells. 
  • Notch 1 signaling regulates peripheral T cell activation. 
  • Notch promotes radioresistance of glioma stem cells. 
  • Notch promotes survival of pre-T cells at the beta-selection checkpoint by regulating cellular metabolism. 
  • Notch-1 regulates pulmonary neuroendocrine cell differentiation in cell lines and in transgenic mice. 
  • Novel functional variants in the Notch pathway and survival of Chinese colorectal cancer. 
  • Phase I trial of weekly MK-0752 in children with refractory central nervous system malignancies: a pediatric brain tumor consortium study. 
  • Pre-TCR signaling inactivates Notch1 transcription by antagonizing E2A. 
  • Protective astrogenesis from the SVZ niche after injury is controlled by Notch modulator Thbs4. 
  • Regulation of myeloid leukaemia by the cell-fate determinant Musashi. 
  • Satb1 Overexpression Drives Tumor-Promoting Activities in Cancer-Associated Dendritic Cells. 
  • The NOTCH1/SNAIL1/MEF2C Pathway Regulates Growth and Self-Renewal in Embryonal Rhabdomyosarcoma. 
  • WNT3A promotes myogenesis of human embryonic stem cells and enhances in vivo engraftment. 
  • Whole-Exome Sequencing of Radiation-Induced Thymic Lymphoma in Mouse Models Identifies Notch1 Activation as a Driver of p53 Wild-Type Lymphoma. 
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  Keywords of People

  • Ciofani, Maria, Associate Professor of Integrative Immunobiology, Cell Biology