Sialic Acid Binding Ig-like Lectin 2
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Subject Areas on Research
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A balance between B cell receptor and inhibitory receptor signaling controls plasma cell differentiation by maintaining optimal Ets1 levels.
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A reevaluation of CD22 expression in human lung cancer.
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Amplified B lymphocyte CD40 signaling drives regulatory B10 cell expansion in mice.
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Anti-CD22 ligand-blocking antibody HB22.7 has independent lymphomacidal properties and augments the efficacy of 90Y-DOTA-peptide-Lym-1 in lymphoma xenografts.
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B Lymphocyte signaling established by the CD19/CD22 loop regulates autoimmunity in the tight-skin mouse.
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B cell antigen receptor and CD40 differentially regulate CD22 tyrosine phosphorylation.
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B-cell homeostasis requires complementary CD22 and BLyS/BR3 survival signals.
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CD19 amplification of B lymphocyte Ca2+ responses: a role for Lyn sequestration in extinguishing negative regulation.
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CD19 and CD22 expression reciprocally regulates tyrosine phosphorylation of Vav protein during B lymphocyte signaling.
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CD19 and CD22 regulate a B lymphocyte signal transduction pathway that contributes to autoimmunity.
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CD19 regulates intrinsic B lymphocyte signal transduction and activation through a novel mechanism of processive amplification.
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CD19, CD21, and CD22: multifaceted response regulators of B lymphocyte signal transduction.
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CD22 and Siglec-G in B cell function and tolerance.
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CD22 cross-linking generates B-cell antigen receptor-independent signals that activate the JNK/SAPK signaling cascade.
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CD22 expression mediates the regulatory functions of peritoneal B-1a cells during the remission phase of contact hypersensitivity reactions.
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CD22 forms a quaternary complex with SHIP, Grb2, and Shc. A pathway for regulation of B lymphocyte antigen receptor-induced calcium flux.
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CD22 is both a positive and negative regulator of B lymphocyte antigen receptor signal transduction: altered signaling in CD22-deficient mice.
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CD22 ligand binding regulates normal and malignant B lymphocyte survival in vivo.
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CD22 negatively and positively regulates signal transduction through the B lymphocyte antigen receptor.
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CD22 regulates B lymphocyte function in vivo through both ligand-dependent and ligand-independent mechanisms.
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CD22 regulates time course of both B cell division and antibody response.
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CD22 serves as a receptor for soluble IgM.
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CD22, a B lymphocyte-specific adhesion molecule that regulates antigen receptor signaling.
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CD22-Binding Synthetic Sialosides Regulate B Lymphocyte Proliferation Through CD22 Ligand-Dependent and Independent Pathways, and Enhance Antibody Production in Mice.
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CD22: a multifunctional receptor that regulates B lymphocyte survival and signal transduction.
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Decreased expression levels of CD22 and L-selectin on peripheral blood B lymphocytes from patients with bullous pemphigoid.
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EndoU is a novel regulator of AICD during peripheral B cell selection.
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Engagement of the adhesion receptor CD22 triggers a potent stimulatory signal for B cells and blocking CD22/CD22L interactions impairs T-cell proliferation.
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Identification of the ligand-binding domains of CD22, a member of the immunoglobulin superfamily that uniquely binds a sialic acid-dependent ligand.
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Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22.
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Lupus-specific antiribonucleoprotein B cell tolerance in nonautoimmune mice is maintained by differentiation to B-1 and governed by B cell receptor signaling thresholds.
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Modulation of B lymphocyte antigen receptor signal transduction by a CD19/CD22 regulatory loop.
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Protective and pathogenic roles for B cells during systemic autoimmunity in NZB/W F1 mice.
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Regulatory B cell (B10 Cell) expansion during Listeria infection governs innate and cellular immune responses in mice.
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Regulatory B cells (B10 cells) and regulatory T cells have independent roles in controlling experimental autoimmune encephalomyelitis initiation and late-phase immunopathogenesis.
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Severely impaired B lymphocyte proliferation, survival, and induction of the c-Myc:Cullin 1 ubiquitin ligase pathway resulting from CD22 deficiency on the C57BL/6 genetic background.
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The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease: systemic sclerosis as a model system.
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The same epitope on CD22 of B lymphocytes mediates the adhesion of erythrocytes, T and B lymphocytes, neutrophils, and monocytes.