Phospholipase C gamma
-
Subject Areas on Research
- 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis.
- A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus.
- A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.
- Activation and signaling of the Abl tyrosine kinase: bidirectional link with phosphoinositide signaling.
- Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy.
- Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.
- Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.
- CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor.
- Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.
- EJ-Ras inhibits phospholipase C gamma 1 but not actin polymerization induced by platelet-derived growth factor-BB via phosphatidylinositol 3-kinase.
- Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease.
- HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome.
- Impairment of kindling development in phospholipase Cγ1 heterozygous mice.
- LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling.
- Ligation of the alpha 2-macroglobulin signalling receptor on macrophages induces protein phosphorylation and an increase in cytosolic pH.
- Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis.
- RAP2 mediates mechanoresponses of the Hippo pathway.
- Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
- Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib.
- The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors.
- The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation.