Phospholipase C gamma
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Subject Areas on Research
- 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis.
- A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus.
- A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1.
- Activation and signaling of the Abl tyrosine kinase: bidirectional link with phosphoinositide signaling.
- Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy.
- An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion.
- Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling.
- Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling.
- Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor.
- CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor.
- Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis.
- Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT.
- EJ-Ras inhibits phospholipase C gamma 1 but not actin polymerization induced by platelet-derived growth factor-BB via phosphatidylinositol 3-kinase.
- Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease.
- Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line.
- HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome.
- Impairment of kindling development in phospholipase Cγ1 heterozygous mice.
- LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway.
- LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI.
- LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation.
- LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling.
- Ligation of the alpha 2-macroglobulin signalling receptor on macrophages induces protein phosphorylation and an increase in cytosolic pH.
- Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding.
- Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis.
- Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development.
- Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL.
- RAP2 mediates mechanoresponses of the Hippo pathway.
- Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease.
- Release of intracellular calcium stores facilitates coxsackievirus entry into polarized endothelial cells.
- Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells.
- Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib.
- Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination.
- TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth.
- The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity.
- The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors.
- The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis.
- The role of membrane-associated adaptors in T cell receptor signalling.
- The role of the LAT-PLC-gamma1 interaction in T regulatory cell function.
- The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation.