Phospholipase C gamma

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  Subject Areas on Research

  • 2B4 utilizes ITAM-containing receptor complexes to initiate intracellular signaling and cytolysis. 
  • A Peptide Uncoupling BDNF Receptor TrkB from Phospholipase Cγ1 Prevents Epilepsy Induced by Status Epilepticus. 
  • A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-gamma1. 
  • Activation and signaling of the Abl tyrosine kinase: bidirectional link with phosphoinositide signaling. 
  • Activation of Cardiac Fibroblast Growth Factor Receptor 4 Causes Left Ventricular Hypertrophy. 
  • An important role of phospholipase Cgamma1 in pre-B-cell development and allelic exclusion. 
  • Arrestin-biased AT1R agonism induces acute catecholamine secretion through TRPC3 coupling. 
  • Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. 
  • Bidirectional signaling links the Abelson kinases to the platelet-derived growth factor receptor. 
  • CXCR3-mediated T-cell chemotaxis involves ZAP-70 and is regulated by signalling through the T-cell receptor. 
  • Disruption of TrkB-mediated phospholipase Cgamma signaling inhibits limbic epileptogenesis. 
  • Dynamic actin polymerization drives T cell receptor-induced spreading: a role for the signal transduction adaptor LAT. 
  • EJ-Ras inhibits phospholipase C gamma 1 but not actin polymerization induced by platelet-derived growth factor-BB via phosphatidylinositol 3-kinase. 
  • Fibroblast growth factor 23 directly targets hepatocytes to promote inflammation in chronic kidney disease. 
  • Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. 
  • HLA-DQA1 and PLCG2 Are Candidate Risk Loci for Childhood-Onset Steroid-Sensitive Nephrotic Syndrome. 
  • Impairment of kindling development in phospholipase Cγ1 heterozygous mice. 
  • LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. 
  • LAT is required for tyrosine phosphorylation of phospholipase cgamma2 and platelet activation by the collagen receptor GPVI. 
  • LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. 
  • LTD at mossy fiber synapses onto stratum lucidum interneurons requires TrkB and retrograde endocannabinoid signaling. 
  • Ligation of the alpha 2-macroglobulin signalling receptor on macrophages induces protein phosphorylation and an increase in cytosolic pH. 
  • Linker for activation of B cells: a functional equivalent of a mutant linker for activation of T cells deficient in phospholipase C-gamma1 binding. 
  • Localized biphasic changes in phosphatidylinositol-4,5-bisphosphate at sites of phagocytosis. 
  • Minimal requirement of tyrosine residues of linker for activation of T cells in TCR signaling and thymocyte development. 
  • Positive and negative regulation of FcepsilonRI-mediated signaling by the adaptor protein LAB/NTAL. 
  • RAP2 mediates mechanoresponses of the Hippo pathway. 
  • Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease. 
  • Release of intracellular calcium stores facilitates coxsackievirus entry into polarized endothelial cells. 
  • Requirement of the Src homology 2 domain protein Shb for T cell receptor-dependent activation of the interleukin-2 gene nuclear factor for activation of T cells element in Jurkat T cells. 
  • Resistance mechanisms for the Bruton's tyrosine kinase inhibitor ibrutinib. 
  • Slow phosphorylation of a tyrosine residue in LAT optimizes T cell ligand discrimination. 
  • TNK1 is a ubiquitin-binding and 14-3-3-regulated kinase that can be targeted to block tumor growth. 
  • The Importance of IL-6 in the Development of LAT-Mediated Autoimmunity. 
  • The isoforms of phospholipase C-gamma are differentially used by distinct human NK activating receptors. 
  • The role of LAT-PLCγ1 interaction in γδ T cell development and homeostasis. 
  • The role of membrane-associated adaptors in T cell receptor signalling. 
  • The role of the LAT-PLC-gamma1 interaction in T regulatory cell function. 
  • The roles of alpha IIb beta 3-mediated outside-in signal transduction, thromboxane A2, and adenosine diphosphate in collagen-induced platelet aggregation.