SELEX Aptamer Technique
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Subject Areas on Research
- A high affinity, antidote-controllable prothrombin and thrombin-binding RNA aptamer inhibits thrombin generation and thrombin activity.
- A hybrid DNA aptamer-dendrimer nanomaterial for targeted cell labeling.
- Antidote control of aptamer therapeutics: the road to a safer class of drug agents.
- Antidote-controlled antithrombotic therapy targeting factor IXa and von Willebrand factor.
- Antidote-controlled platelet inhibition targeting von Willebrand factor with aptamers.
- Antimetastatic potential of PAI-1-specific RNA aptamers.
- Aptamer applications for targeted cancer therapy.
- Aptamers Coming of Age at Twenty-Five.
- Aptamers as Therapeutics.
- Aptamers selected against the unglycosylated EGFRvIII ectodomain and delivered intracellularly reduce membrane-bound EGFRvIII and induce apoptosis.
- Base-pairing potential identified by in vitro selection predicts the kinked RNA backbone observed in the crystal structure of the alfalfa mosaic virus RNA-coat protein complex.
- Cell-internalization SELEX: method for identifying cell-internalizing RNA aptamers for delivering siRNAs to target cells.
- Cell-specific aptamers for targeted therapies.
- Comparing human pancreatic cell secretomes by in vitro aptamer selection identifies cyclophilin B as a candidate pancreatic cancer biomarker.
- Delivery of chemo-sensitizing siRNAs to HER2+-breast cancer cells using RNA aptamers.
- Generation of an anticoagulant aptamer that targets factor V/Va and disrupts the FVa-membrane interaction in normal and COVID-19 patient samples.
- Identification and characterization of an agonistic aptamer against the T cell costimulatory receptor, OX40.
- Identification of liver cancer-specific aptamers using whole live cells.
- Inhibiting the intrinsic pathway of coagulation with a factor XII-targeting RNA aptamer.
- Nucleic acid aptamers as adjuncts to vaccine development.
- Nucleic acid aptamers as antithrombotic agents: Opportunities in extracellular therapeutics.
- Opportunity nox: the future of NADPH oxidases as therapeutic targets in cardiovascular disease.
- Osteopontin regulates epithelial mesenchymal transition-associated growth of hepatocellular cancer in a mouse xenograft model.
- RNA aptamer-based functional ligands of the neurotrophin receptor, TrkB.
- Rapid identification of cell-specific, internalizing RNA aptamers with bioinformatics analyses of a cell-based aptamer selection.
- Regulatable aptamers in medicine: focus on antithrombotic strategies.
- Simultaneous generation of aptamers to multiple gamma-carboxyglutamic acid proteins from a focused aptamer library using DeSELEX and convergent selection.
- The development and testing of aptamers for cancer.
- Therapeutic Aptamers: Evolving to Find their Clinical Niche.
- Translating nucleic acid aptamers to antithrombotic drugs in cardiovascular medicine.