Nitric Oxide Synthase Type II

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  Subject Areas on Research

  • A new NOS2 promoter polymorphism associated with increased nitric oxide production and protection from severe malaria in Tanzanian and Kenyan children. 
  • A novel model system for studying the double-edged roles of nitric oxide production in pancreatic cancer growth and metastasis. 
  • A novel role for erythropoietin during fibrin-induced wound-healing response. 
  • A novel, clinically relevant animal model of metastatic pancreatic adenocarcinoma biology and therapy. 
  • APOE genotype-specific differences in human and mouse macrophage nitric oxide production. 
  • APOE genotype-specific differences in the innate immune response. 
  • APOE-mimetic peptides reduce behavioral deficits, plaques and tangles in Alzheimer's disease transgenics. 
  • Abrogation of α-synuclein-mediated dopaminergic neurodegeneration in LRRK2-deficient rats. 
  • Activation of matrix metalloproteinases following anti-Aβ immunotherapy; implications for microhemorrhage occurrence. 
  • Acute local subcutaneous VEGF165 injection for augmentation of skin flap viability: efficacy and mechanism. 
  • Addition of nitric oxide donor S-nitroso-N-acetylcysteine to selective iNOS inhibitor 1400W further improves contractile function in reperfused skeletal muscle. 
  • Alteration in regulation of inflammatory response to influenza a virus and endotoxin in suckling rat pups: a potential relationship to sudden infant death syndrome. 
  • Amyloid reduction by amyloid-beta vaccination also reduces mouse tau pathology and protects from neuron loss in two mouse models of Alzheimer's disease. 
  • Analysis of single nucleotide polymorphisms in the NOS2A gene and interaction with smoking in age-related macular degeneration. 
  • Anti-inflammatory and vasoprotective activity of a retroviral-derived peptide, homologous to human endogenous retroviruses: endothelial cell effects. 
  • Anti-inflammatory effects of progesterone in lipopolysaccharide-stimulated BV-2 microglia. 
  • Antibiotic-induced changes in the microbiota disrupt redox dynamics in the gut. 
  • Apolipoprotein E acts to increase nitric oxide production in macrophages by stimulating arginine transport. 
  • Arginase1 Deficiency in Monocytes/Macrophages Upregulates Inducible Nitric Oxide Synthase To Promote Cutaneous Contact Hypersensitivity. 
  • Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease. 
  • Association of SLC11A1 with tuberculosis and interactions with NOS2A and TLR2 in African-Americans and Caucasians. 
  • Bacterial flavohemoglobin: a molecular tool to probe mammalian nitric oxide biology. 
  • Beta-adrenoceptor agonists stimulate endothelial nitric oxide synthase in rat urinary bladder urothelial cells. 
  • Biaxial strain effects on cells from the inner and outer regions of the meniscus. 
  • Bioenergetic Differences in the Airway Epithelium of Lean Versus Obese Asthmatics Are Driven by Nitric Oxide and Reflected in Circulating Platelets. 
  • Biphasic effects of interleukin-1beta on osteoblast differentiation in vitro. 
  • Calmodulin overexpression causes Ca(2+)-dependent apoptosis of pancreatic beta cells, which can be prevented by inhibition of nitric oxide synthase. 
  • Capillary Electrophoresis-High Resolution Mass Spectrometry for Measuring In Vivo Arginine Isotope Incorporation in Alzheimer's Disease Mouse Models. 
  • Characterization of NO and cytokine production in immune-activated microglia and peritoneal macrophages derived from a mouse model expressing the human NOS2 gene on a mouse NOS2 knockout background. 
  • Characterization of key residues in the subdomain encoded by exons 8 and 9 of human inducible nitric oxide synthase: a critical role for Asp-280 in substrate binding and subunit interactions. 
  • Characterization of short range DNA looping in endotoxin-mediated transcription of the murine inducible nitric-oxide synthase (iNOS) gene. 
  • Characterization of the PC4 binding domain and its interactions with HNF4alpha. 
  • Characterization of turkey inducible nitric oxide synthase and identification of its expression in the intestinal epithelium following astrovirus infection. 
  • Chronic ethanol exposure potentiates lipopolysaccharide liver injury despite inhibiting Jun N-terminal kinase and caspase 3 activation. 
  • Chronic lymphocytic leukemia cell CD38 expression and inducible nitric oxide synthase expression are associated with serum IL-4 levels. 
  • Combined loss of neuronal and endothelial nitric oxide synthase causes premature mortality and age-related hypertrophic cardiac remodeling in mice. 
  • Concurrent production of reactive oxygen and nitrogen species by airway epithelial cells in vitro. 
  • Contributions of endothelial and neuronal nitric oxide synthases to cerebrovascular responses to hyperoxia. 
  • Contributions of nitric oxide synthase isoforms to pulmonary oxygen toxicity, local vs. mediated effects. 
  • Dietary glycine inhibits angiogenesis during wound healing and tumor growth. 
  • Differential activation of nitric-oxide synthase isozymes by calmodulin-troponin C chimeras. 
  • Differential expression of arginase and iNOS in the lung in sepsis. 
  • Differential regulation of inducible nitric oxide synthase gene expression by ethanol in the human intestinal epithelial cell line DLD-1. 
  • Diverse inflammatory responses in transgenic mouse models of Alzheimer's disease and the effect of immunotherapy on these responses. 
  • Effect of ethanol on tumor necrosis factor signaling during liver regeneration. 
  • Elevated nitric oxide production in children with malarial anemia: hemozoin-induced nitric oxide synthase type 2 transcripts and nitric oxide in blood mononuclear cells. 
  • Endotoxin mediated-iNOS induction causes insulin resistance via ONOO⁻ induced tyrosine nitration of IRS-1 in skeletal muscle. 
  • Endotoxin-mediated S-nitrosylation of p50 alters NF-kappa B-dependent gene transcription in ANA-1 murine macrophages. 
  • Endotoxin-mediated nitric oxide synthesis inhibits IL-1beta gene transcription in ANA-1 murine macrophages. 
  • Enhanced capillary amyloid angiopathy-associated pathology in Tg-SwDI mice with deleted nitric oxide synthase 2. 
  • Epithelial invasion by Escherichia coli bearing Dr fimbriae is controlled by nitric oxide-regulated expression of CD55. 
  • Expression of the transcription factor STAT-1 alpha in insulinoma cells protects against cytotoxic effects of multiple cytokines. 
  • Fatty liver vulnerability to endotoxin-induced damage despite NF-kappaB induction and inhibited caspase 3 activation. 
  • Gender and estrogen supplementation increases severity of experimental choroidal neovascularization. 
  • Gene and protein expressions of nitric oxide synthases in ischemia-reperfused peripheral nerve of the rat. 
  • Genetic association analyses of nitric oxide synthase genes and neural tube defects vary by phenotype. 
  • Glioma stem cell proliferation and tumor growth are promoted by nitric oxide synthase-2. 
  • Glutamine attenuation of cell death and inducible nitric oxide synthase expression following inflammatory cytokine-induced injury is dependent on heat shock factor-1 expression. 
  • Glutamine therapy improves outcome of in vitro and in vivo experimental colitis models. 
  • Glycolysis-dependent histone deacetylase 4 degradation regulates inflammatory cytokine production. 
  • Guanylate binding proteins promote caspase-11-dependent pyroptosis in response to cytoplasmic LPS. 
  • Hepatocyte nuclear factor-4alpha mediates redox sensitivity of inducible nitric-oxide synthase gene transcription. 
  • Host response to infection: the role of CpG DNA in induction of cyclooxygenase 2 and nitric oxide synthase 2 in murine macrophages. 
  • IL-4 and interferon gamma regulate expression of inducible nitric oxide synthase in chronic lymphocytic leukemia cells. 
  • IRF3 inhibits IFN-γ-mediated restriction of intracellular pathogens in macrophages independently of IFNAR. 
  • IRG1 and Inducible Nitric Oxide Synthase Act Redundantly with Other Interferon-Gamma-Induced Factors To Restrict Intracellular Replication of Legionella pneumophila. 
  • Identification of S-nitrosylated proteins in endotoxin-stimulated RAW264.7 murine macrophages. 
  • Identification of a Novel Inhibitor of Human Rhinovirus Replication and Inflammation in Airway Epithelial Cells. 
  • Identification of a negative feedback loop in biological oxidant formation fegulated by 4-hydroxy-2-(E)-nonenal. 
  • Immune control of tuberculosis by IFN-gamma-inducible LRG-47. 
  • Impaired liver regeneration in inducible nitric oxide synthasedeficient mice. 
  • In vitro and in vivo inhibitory activities of rutin, wogonin, and quercetin on lipopolysaccharide-induced nitric oxide and prostaglandin E(2) production. 
  • Inducible nitric oxide synthase (NOS2) promoter CCTTT repeat polymorphism: relationship to in vivo nitric oxide production/NOS activity in an asymptomatic malaria-endemic population. 
  • Inducible nitric oxide synthase expression by peritoneal macrophages in endometriosis-associated infertility. 
  • Inducible nitric oxide synthase promotes cytokine expression in cardiac allografts but is not required for efficient rejection. 
  • Induction of arginase isoforms in the lung during hyperoxia. 
  • Induction of cyclooxygenase-2 by mechanical stress through a nitric oxide-regulated pathway. 
  • Inhibition of iNOS attenuates skeletal muscle reperfusion injury in extracellular superoxide dismutase knockout mice. 
  • Inhibition of iNOS with 1400W improves contractile function and alters nos gene and protein expression in reperfused skeletal muscle. 
  • Inhibition of nitric oxide synthase by cobalamins and cobinamides. 
  • Inhibition of nitric oxide synthase inhibitors and lipopolysaccharide induced inducible NOS and cyclooxygenase-2 gene expressions by rutin, quercetin, and quercetin pentaacetate in RAW 264.7 macrophages. 
  • Intact nitric oxide synthase II gene is required for interferon-beta-mediated suppression of growth and metastasis of pancreatic adenocarcinoma. 
  • Interleukin 12 protects from a T helper type 1-mediated autoimmune disease, experimental autoimmune uveitis, through a mechanism involving interferon gamma, nitric oxide, and apoptosis. 
  • Interleukin 1beta-stimulated production of nitric oxide in rat hepatocytes is mediated through endogenous synthesis of interferon gamma. 
  • Intra-articular depletion of macrophages increases acute synovitis and alters macrophage polarity in the injured mouse knee. 
  • Intraprotein electron transfer in inducible nitric oxide synthase holoenzyme. 
  • L-Citrulline increases nitric oxide and improves control in obese asthmatics. 
  • Lack of nitric oxide synthases increases lipoprotein immune complex deposition in the aorta and elevates plasma sphingolipid levels in lupus. 
  • Leptin is key to peroxynitrite-mediated oxidative stress and Kupffer cell activation in experimental non-alcoholic steatohepatitis. 
  • Leukocyte iNOS is required for inflammation and pathological remodeling in ischemic heart failure. 
  • Lithium treatment of APPSwDI/NOS2-/- mice leads to reduced hyperphosphorylated tau, increased amyloid deposition and altered inflammatory phenotype. 
  • Longitudinal study of differential protein expression in an Alzheimer's mouse model lacking inducible nitric oxide synthase. 
  • Malaria severity and human nitric oxide synthase type 2 (NOS2) promoter haplotypes. 
  • Manganese porphyrin reduces retinal injury induced by ocular hypertension in rats. 
  • Mechanical stress and nitric oxide influence leukotriene production in cartilage. 
  • Mice deficient in LRG-47 display enhanced susceptibility to Trypanosoma cruzi infection associated with defective hemopoiesis and intracellular control of parasite growth. 
  • Mice deficient in inducible nitric oxide synthase are susceptible to experimental autoimmune uveoretinitis. 
  • Modulation of in vivo cardiac function by myocyte-specific nitric oxide synthase-3. 
  • NF-kappaB p65 involves in reperfusion injury and iNOS gene regulation in skeletal muscle. 
  • NO synthase 2 (NOS2) deletion promotes multiple pathologies in a mouse model of Alzheimer's disease. 
  • NOS2 regulation of LPS-induced airway inflammation via S-nitrosylation of NF-{kappa}B p65. 
  • NOS2 regulation of NF-kappaB by S-nitrosylation of p65. 
  • NOS2A and the modulating effect of cigarette smoking in Parkinson's disease. 
  • NOS2A, TLR4, and IFNGR1 interactions influence pulmonary tuberculosis susceptibility in African-Americans. 
  • Neuroinflammation and α-synuclein dysfunction potentiate each other, driving chronic progression of neurodegeneration in a mouse model of Parkinson's disease. 
  • Nitric oxide as an inflammatory mediator in autoimmune MRL-lpr/lpr mice. 
  • Nitric oxide involvement in reperfusion injury of denervated muscle. 
  • Nitric oxide mediates relative airway hyporesponsiveness to lipopolysaccharide in surfactant protein A-deficient mice. 
  • Nitric oxide production and mononuclear cell nitric oxide synthase activity in malaria-tolerant Papuan adults. 
  • Nitric oxide production and nitric oxide synthase type 2 expression by human mononuclear phagocytes: a review. 
  • Nitric oxide regulates matrix metalloproteinase-9 activity by guanylyl-cyclase-dependent and -independent pathways. 
  • Nitric oxide regulates the heart by spatial confinement of nitric oxide synthase isoforms. 
  • Nitric oxide regulation of myocardial contractility and calcium cycling: independent impact of neuronal and endothelial nitric oxide synthases. 
  • Nitric oxide synthase 2 and cyclooxygenase 2 interactions in inflammation. 
  • Nitric oxide synthase 2 promoter polymorphisms and systemic lupus erythematosus in african-americans. 
  • Nitric oxide synthase 2(Lambaréné) (G-954C), increased nitric oxide production, and protection against malaria. 
  • Nitric oxide synthase type 2 promoter polymorphisms, nitric oxide production, and disease severity in Tanzanian children with malaria. 
  • Nitric oxide synthase-2 induction optimizes cardiac mitochondrial biogenesis after endotoxemia. 
  • Nitric oxide synthase-2 regulates mitochondrial Hsp60 chaperone function during bacterial peritonitis in mice. 
  • Nitric oxide--friend or foe in arthritis? 
  • Nitric oxide-dependent osteopontin expression induces metastatic behavior in HepG2 cells. 
  • Obesity, insulin resistance, and skeletal muscle nitric oxide synthase. 
  • Osteopontin induces ubiquitin-dependent degradation of STAT1 in RAW264.7 murine macrophages. 
  • Osteopontin mediates Stat1 degradation to inhibit iNOS transcription in a cecal ligation and puncture model of sepsis. 
  • Oxidant stress from nitric oxide synthase-3 uncoupling stimulates cardiac pathologic remodeling from chronic pressure load. 
  • Pacing-induced heart failure: a model to study the mechanism of disease progression and novel therapy in heart failure. 
  • Pathogen-specific loss of host resistance in mice lacking the IFN-gamma-inducible gene IGTP. 
  • Peroxide-mediated chromatin remodelling of a nuclear factor kappa B site in the mouse inducible nitric oxide synthase promoter. 
  • Phosphorylation of Ser158 regulates inflammatory redox-dependent hepatocyte nuclear factor-4alpha transcriptional activity. 
  • Polymorphisms of the neuronal and inducible nitric oxide synthase genes and the risk of cutaneous melanoma: a case-control study. 
  • Post-transcriptional inhibition of lipopolysaccharide-induced expression of inducible nitric oxide synthase by Gö6976 in murine microglia. 
  • Prevention of influenza-induced lung injury in mice overexpressing extracellular superoxide dismutase. 
  • Progression of amyloid pathology to Alzheimer's disease pathology in an amyloid precursor protein transgenic mouse model by removal of nitric oxide synthase 2. 
  • Proteasome inhibitor attenuates skeletal muscle reperfusion injury by blocking the pathway of nuclear factor-kappaB activation. 
  • Protection from experimental asthma by an endogenous bronchodilator. 
  • Proteomic analysis of the NOS2 interactome in human airway epithelial cells. 
  • Proteomic characterization of the cellular response to nitrosative stress mediated by s-nitrosoglutathione reductase inhibition. 
  • Pulmonary expression of iNOS and HO-1 protein is upregulated in a rat model of prehepatic portal hypertension. 
  • Quantitative measurement of postural sway in mouse models of human neurodegenerative disease. 
  • Redox regulation of the rat hepatocyte iNOS promoter. 
  • Redox-mediated upregulation of hepatocyte iNOS transcription requires coactivator PC4. 
  • Reduction of NOS2 overexpression in rheumatoid arthritis patients treated with anti-tumor necrosis factor alpha monoclonal antibody (cA2). 
  • Regulation of HIF-1alpha stability through S-nitrosylation. 
  • Reperfusion injury in skeletal muscle is reduced in inducible nitric oxide synthase knockout mice. 
  • Reperfusion injury is reduced in skeletal muscle by inhibition of inducible nitric oxide synthase. 
  • Role of mitogen-activated protein kinase in osteoblast differentiation. 
  • S-Nitrosation of arginase 1 requires direct interaction with inducible nitric oxide synthase 
  • S-Nitrosoglutathione protects the spinal bladder: novel therapeutic approach to post-spinal cord injury bladder remodeling. 
  • S-nitrosylation in the regulation of gene transcription. 
  • STAT1 is essential for antimicrobial effector function but dispensable for gamma interferon production during Toxoplasma gondii infection. 
  • Selection of insulinoma cell lines with resistance to interleukin-1beta- and gamma-interferon-induced cytotoxicity. 
  • Serine/threonine phosphorylation regulates HNF-4alpha-dependent redox-mediated iNOS expression in hepatocytes. 
  • Simvastatin increases endothelial nitric oxide synthase and ameliorates cerebral vasospasm resulting from subarachnoid hemorrhage. 
  • Stable expression of manganese superoxide dismutase (MnSOD) in insulinoma cells prevents IL-1beta- induced cytotoxicity and reduces nitric oxide production. 
  • Stat1 acetylation inhibits inducible nitric oxide synthase expression in interferon-gamma-treated RAW264.7 murine macrophages. 
  • Superoxide dismutase-3 promotes full expression of the EPO response to hypoxia. 
  • Superoxide enhances interleukin 1beta-mediated transcription of the hepatocyte-inducible nitric oxide synthase gene. 
  • Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production. 
  • Systemic nitric oxide production in human malaria. II. Analysis of mononuclear cell nitric oxide synthase type 2 antigen expression. 
  • The apolipoprotein E-mimetic peptide COG112 inhibits the inflammatory response to Citrobacter rodentium in colonic epithelial cells by preventing NF-kappaB activation. 
  • The dichotomous role of nitric oxide in the pathogenesis of accelerated atherosclerosis associated with systemic lupus erythematosus. 
  • The effect of dynamic mechanical compression on nitric oxide production in the meniscus. 
  • The effects of NOS2 gene deletion on mice expressing mutated human AbetaPP. 
  • The effects of cyclic mechanical strain and tumor necrosis factor alpha on the response of cells of the meniscus. 
  • The effects of static and intermittent compression on nitric oxide production in articular cartilage explants. 
  • The human myoepithelial cell displays a multifaceted anti-angiogenic phenotype. 
  • The impact of human and mouse differences in NOS2 gene expression on the brain's redox and immune environment. 
  • The indolocarbazole Gö6976 protects neurons from lipopolysaccharide/interferon-gamma-induced cytotoxicity in murine neuron/glia co-cultures. 
  • The involvement of superoxide and iNOS-derived NO in cardiac dysfunction induced by pro-inflammatory cytokines. 
  • The release of microparticles by RAW 264.7 macrophage cells stimulated with TLR ligands. 
  • Thermodynamics of oxidation-reduction reactions in mammalian nitric-oxide synthase isoforms. 
  • Toll-like receptor 4 mediates mitochondrial DNA damage and biogenic responses after heat-inactivated E. coli. 
  • Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3. 
  • Transient hypoxia stimulates mitochondrial biogenesis in brain subcortex by a neuronal nitric oxide synthase-dependent mechanism. 
  • Tumor cells upregulate normoxic HIF-1α in response to doxorubicin. 
  • Vascular amyloid alters astrocytic water and potassium channels in mouse models and humans with Alzheimer's disease. 
  • beta(3)-adrenoceptor deficiency blocks nitric oxide-dependent inhibition of myocardial contractility. 
  • mNos2 deletion and human NOS2 replacement in Alzheimer disease models. 
  • α-Synuclein fibrils recruit peripheral immune cells in the rat brain prior to neurodegeneration. 
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  Keywords of People

  • McLendon, Roger Edwin, Professor of Pathology, Pathology
  • Taylor, Gregory Alan, Professor in Medicine, Integrative Immunobiology