Receptors, Death Domain

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  Subject Areas on Research

  • Ablation of c-FLIP in hepatocytes enhances death-receptor mediated apoptosis and toxic liver injury in vivo. 
  • Camptothecin and Fas receptor agonists synergistically induce medulloblastoma cell death: ROS-dependent mechanisms. 
  • Control of thymic T cell maturation, deletion and egress by the RNA-binding protein HuR. 
  • Hypophosphorylation of the architectural chromatin protein DEK in death-receptor-induced apoptosis revealed by the isotope coded protein label proteomic platform. 
  • Physiological consequences of programmed necrosis, an alternative form of cell demise. 
  • Sweet modification and regulation of death receptor signalling pathway. 
  • The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.