Fas Ligand Protein
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Subject Areas on Research
- Acute pancreatitis induces FasL gene expression and apoptosis in the liver.
- Analysis of FasL and TRAIL induced apoptosis pathways in glioma cells.
- Apoptosis and B cell tolerance.
- Apoptotic variants as predictors of risk of oropharyngeal cancer recurrence after definitive radiotherapy.
- Camptothecin and Fas receptor agonists synergistically induce medulloblastoma cell death: ROS-dependent mechanisms.
- Chronic activation of the kinase IKKβ impairs T cell function and survival.
- Down-regulation of the orphan nuclear receptor ROR gamma t is essential for T lymphocyte maturation.
- Endogenous expression of transforming growth factor beta1 inhibits growth and tumorigenicity and enhances Fas-mediated apoptosis in a murine high-grade glioma model.
- Ex vivo pediatric brain tumors express Fas (CD95) and FasL (CD95L) and are resistant to apoptosis induction.
- Expansion or elimination of B cells in vivo: dual roles for CD40- and Fas (CD95)-ligands modulated by the B cell antigen receptor.
- FAS and FASLG genetic variants and risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.
- Fas on renal parenchymal cells does not promote autoimmune nephritis in MRL mice.
- Fas/FasL play a central role in pancreatitis-induced hepatocyte apoptosis.
- Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis.
- Hepatic allograft-derived Kupffer cells regulate T cell response in rats.
- Induction of plasma (TRAIL), TNFR-2, Fas ligand, and plasma microparticles after human immunodeficiency virus type 1 (HIV-1) transmission: implications for HIV-1 vaccine design.
- Kupffer cell-derived Fas ligand plays a role in liver injury and hepatocyte death.
- LKLF: A transcriptional regulator of single-positive T cell quiescence and survival.
- Loss of the perforin cytotoxic pathway predisposes mice to experimental cytomegalovirus retinitis.
- Metastatic colorectal cancer cells from patients previously treated with chemotherapy are sensitive to T-cell killing mediated by CEA/CD3-bispecific T-cell-engaging BiTE antibody.
- Nuclear factor-kappaB mediates Kupffer cell apoptosis through transcriptional activation of Fas/FasL.
- Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry.
- Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck.
- Polymorphisms of the FAS and FAS ligand genes associated with risk of cutaneous malignant melanoma.
- RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells.
- Repression of B7.2 on self-reactive B cells is essential to prevent proliferation and allow Fas-mediated deletion by CD4(+) T cells.
- Role of LAT in the granule-mediated cytotoxicity of CD8 T cells.
- Site disparities in apoptotic variants as predictors of risk for second primary malignancy in patients with squamous cell carcinoma of the head and neck.
- Soluble Fas ligand blocks destructive corneal inflammation in mouse models of corneal epithelial debridement and LPS induced keratitis.
- Subtype-Specific Radiation Response and Therapeutic Effect of FAS Death Receptor Modulation in Human Breast Cancer.
- The cytolytic molecules Fas ligand and TRAIL are required for murine thymic graft-versus-host disease.
- The oncogenic microRNA miR-21 promotes regulated necrosis in mice.
- The p35 relative, p49, inhibits mammalian and Drosophila caspases including DRONC and protects against apoptosis.
- The role of p65 NF-kappaB/RelA in pancreatitis-induced Kupffer cell apoptosis.
- Transgenic expression of the viral FLIP MC159 causes lpr/gld-like lymphoproliferation and autoimmunity.
- ZAP-70 tyrosine kinase is required for the up-regulation of Fas ligand in activation-induced T cell apoptosis.
- c-FLIP maintains tissue homeostasis by preventing apoptosis and programmed necrosis.
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Keywords of People
- Ferrari, Guido, Professor in Surgery, Molecular Genetics and Microbiology
- Weinhold, Kent James, Joseph W. and Dorothy W. Beard Distinguished Professor of Experimental Surgery, in the School of Medicine, Immunology