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Tumor Necrosis Factor Receptor Superfamily, Member 9
Subject Areas on Research
4-1BB Agonism Averts TIL Exhaustion and Licenses PD-1 Blockade in Glioblastoma and Other Intracranial Cancers.
CD137 stimulation enhances the antilymphoma activity of anti-CD20 antibodies.
In Vivo Expansion and Antitumor Activity of Coinfused CD28- and 4-1BB-Engineered CAR-T Cells in Patients with B Cell Leukemia.
Multivalent 4-1BB binding aptamers costimulate CD8+ T cells and inhibit tumor growth in mice.
Preventing Lck Activation in CAR T Cells Confers Treg Resistance but Requires 4-1BB Signaling for Them to Persist and Treat Solid Tumors in Nonlymphodepleted Hosts.
