Apolipoprotein E3
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Subject Areas on Research
- A SAGE study of apolipoprotein E3/3, E3/4 and E4/4 allele-specific gene expression in hippocampus in Alzheimer disease.
- A TOMM40 variable-length polymorphism predicts the age of late-onset Alzheimer's disease.
- A novel apoE-derived therapeutic reduces vasospasm and improves outcome in a murine model of subarachnoid hemorrhage.
- A pooled case-control study of the apolipoprotein E (APOE) gene in age-related maculopathy.
- APOE and the regulation of microglial nitric oxide production: a link between genetic risk and oxidative stress.
- APOE genotype affects outcome in a murine model of sepsis: implications for a new treatment strategy.
- APOE genotype-specific differences in human and mouse macrophage nitric oxide production.
- APOE genotype-specific differences in the innate immune response.
- Age-Dependent Effects of apoE Reduction Using Antisense Oligonucleotides in a Model of β-amyloidosis.
- Altered immune responses in apolipoprotein E-deficient mice.
- An apolipoprotein E-based therapeutic improves outcome and reduces Alzheimer's disease pathology following closed head injury: evidence of pharmacogenomic interaction.
- Androgen-mediated immune function is altered by the apolipoprotein E gene.
- Apo E structure determines VLDL clearance and atherosclerosis risk in mice.
- ApoE genotype-specific inhibition of apoptosis.
- ApoE isoform-specific effects on LTP: blockade by oligomeric amyloid-beta1-42.
- ApoE3 binding to tau tandem repeat I is abolished by tau serine262 phosphorylation.
- ApoE4 impairs hippocampal plasticity isoform-specifically and blocks the environmental stimulation of synaptogenesis and memory.
- Apolipoprotein E and Alzheimer disease: an update on genetic and functional analyses.
- Apolipoprotein E associates with beta amyloid peptide of Alzheimer's disease to form novel monofibrils. Isoform apoE4 associates more efficiently than apoE3.
- Apolipoprotein E binds to and potentiates the biological activity of ciliary neurotrophic factor.
- Apolipoprotein E controls the risk and age at onset of Parkinson disease.
- Apolipoprotein E gene polymorphisms and retinal vascular signs: the atherosclerosis risk in communities (ARIC) study.
- Apolipoprotein E gene polymorphisms are not associated with diabetic retinopathy: the atherosclerosis risk in communities study.
- Apolipoprotein E genotype and oxidative stress response to traumatic brain injury.
- Apolipoprotein E isoform mediated regulation of nitric oxide release.
- Apolipoprotein E isoform-specific differences in outcome from focal ischemia in transgenic mice.
- Apolipoprotein E isotype-dependent modulation of microRNA-146a in plasma and brain.
- Apolipoprotein E level and cholesterol are associated with reduced synaptic amyloid beta in Alzheimer's disease and apoE TR mouse cortex.
- Apolipoprotein E uptake and low-density lipoprotein receptor-related protein expression by the NTera2/D1 cell line: a cell culture model of relevance for late-onset Alzheimer's disease.
- Apolipoprotein E, survival in Alzheimer's disease patients, and the competing risks of death and Alzheimer's disease.
- Apolipoprotein E-epsilon 2 and Alzheimer's disease: genotype influences pathologic phenotype.
- Apolipoprotein E-epsilon 4 frequency in geriatric depression.
- Apolipoprotein E-genotype dependent hippocampal and cortical responses to traumatic brain injury.
- Apolipoprotein E-low density lipoprotein receptor interaction affects spatial memory retention and brain ApoE levels in an isoform-dependent manner.
- Apolipoprotein E4 Impairs Neuronal Insulin Signaling by Trapping Insulin Receptor in the Endosomes.
- Apolipoprotein E4 decreases whereas apolipoprotein E3 increases the level of secreted amyloid precursor protein after closed head injury.
- Apolipoprotein E4 exaggerates diabetic dyslipidemia and atherosclerosis in mice lacking the LDL receptor.
- Apolipoprotein E4 stimulates cAMP response element-binding protein transcriptional activity through the extracellular signal-regulated kinase pathway.
- Apolipoprotein e gene and age-related maculopathy in older individuals: the cardiovascular health study.
- Association between APOE epsilon 2/epsilon 3/epsilon 4 polymorphism and disability severity in a national long-term care survey sample.
- Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.
- Defective neuronal sprouting by human apolipoprotein E4 is a gain-of-negative function.
- Disruption of arterial perivascular drainage of amyloid-β from the brains of mice expressing the human APOE ε4 allele.
- ERG responses and microarray analysis of gene expression in a multifactorial murine model of age-related retinal degeneration.
- Endogenous apolipoprotein E suppresses LPS-stimulated microglial nitric oxide production.
- Estradiol enhances long term potentiation in hippocampal slices from aged apoE4-TR mice.
- Functional brain abnormalities in young adults at genetic risk for late-onset Alzheimer's dementia.
- High-fat/high-cholesterol diet promotes a S1P receptor-mediated antiapoptotic activity for VLDL.
- Hippocampal sulcal cavities on MRI: relationship to age and apolipoprotein E genotype.
- Human apoE targeted replacement mouse lines: h-apoE4 and h-apoE3 mice differ on spatial memory performance and avoidance behavior.
- Human apoE4-targeted replacement mice display synaptic deficits in the absence of neuropathology.
- Human apolipoprotein E isoform-specific differences in neuronal sprouting in organotypic hippocampal culture.
- Human apolipoprotein E redistributes fibrillar amyloid deposition in Tg-SwDI mice.
- Human apolipoprotein E2, E3, and E4 isoform-specific transgenic mice: human-like pattern of glial and neuronal immunoreactivity in central nervous system not observed in wild-type mice.
- Human apolipoprotein E4 alters the amyloid-beta 40:42 ratio and promotes the formation of cerebral amyloid angiopathy in an amyloid precursor protein transgenic model.
- Human apolipoprotein E4 targeted replacement mice show increased prevalence of intracerebral hemorrhage associated with vascular amyloid deposition.
- Human apolipoprotein E4 worsens acute axonal pathology but not amyloid-β immunoreactivity after traumatic brain injury in 3xTG-AD mice.
- Identification of plasma biomarkers of TBI outcome using proteomic approaches in an APOE mouse model.
- Impaired neuronal plasticity in transgenic mice expressing human apolipoprotein E4 compared to E3 in a model of entorhinal cortex lesion.
- Inherited frailty. ApoE alleles determine survival after a diagnosis of heart disease or stroke at ages 85+.
- Isoform-specific interactions of apolipoprotein E with the microtubule-associated protein MAP2c: implications for Alzheimer's disease.
- Microglial function in human APOE3 and APOE4 transgenic mice: altered arginine transport.
- Middle-aged human apoE4 targeted-replacement mice show retention deficits on a wide range of spatial memory tasks.
- Patterns of brain activation in people at risk for Alzheimer's disease.
- Pharmacogenetic predictors of statin-mediated low-density lipoprotein cholesterol reduction and dose response.
- Prefrontal activation patterns in subjects at risk for Alzheimer disease.
- TOMM40'523 variant and cognitive decline in older persons with APOE ε3/3 genotype.
- Targeted replacement of the mouse apolipoprotein E gene with the common human APOE3 allele enhances diet-induced hypercholesterolemia and atherosclerosis.
- Targeting of nonlipidated, aggregated apoE with antibodies inhibits amyloid accumulation.
- The effect of TOMM40 poly-T length on gray matter volume and cognition in middle-aged persons with APOE ε3/ε3 genotype.
- The role of apolipoprotein E in Alzheimer's disease: pharmacogenomic target selection.
- Uptake and internalization of exogenous apolipoprotein E3 by cultured human central nervous system neurons.
- Vascular smooth muscle actin is reduced in Alzheimer disease brain: a quantitative analysis.
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Keywords of People
- Laskowitz, Daniel Todd, Professor of Neurology, Duke Innovation & Entrepreneurship
- Warner, David Samuel, Distinguished Professor of Anesthesiology, in the School of Medicine, Neurobiology